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Adam S Faye, Fernanda Polubriaginof, Peter H R Green, David K Vawdrey, Nicholas Tatonetti, Benjamin Lebwohl
BACKGROUND & AIMS: Given the increased morbidity and potential mortality of celiac disease, guidelines recommend screening high-risk individuals, including first-degree relatives of patients. We assessed how commonly celiac disease testing occurs in these individuals and identified factors that influence testing. METHODS: Relatives of 2081 patients with biopsy-diagnosed celiac disease and followed at Columbia University Medical Center were identified using relationship inference from the electronic health record-a validated method that uses emergency contact information to identify familial relationships...
June 15, 2018: Clinical Gastroenterology and Hepatology
Prashant Singh, Ananya Arora, Tor A Strand, Daniel A Leffler, Markku Mäki, Ciaran P Kelly, Vineet Ahuja, Govind K Makharia
GOALS: To perform a systematic review and meta-analysis to estimate the overall diagnostic accuracy of point of care tests (POCTs) for diagnosing celiac disease (CD). BACKGROUND: Recently, POCTs for CD have been developed and are commercially available. Studies have reported significant variability in their sensitivity (70% to 100%) and specificity (85% to 100%). STUDY: We searched MEDLINE, EMBASE databases, and the Cochrane library through June 2017...
June 16, 2018: Journal of Clinical Gastroenterology
L Grode, B H Bech, O Plana-Ripoll, M Bliddal, I E Agerholm, P Humaidan, C H Ramlau-Hansen
STUDY QUESTION: How does celiac disease (CD) influence women's reproductive life, both prior to and after the diagnosis? SUMMARY ANSWER: Prior to the diagnosis of CD, an increased risk of adverse pregnancy outcomes was seen, whereas after the diagnosis, no influence on reproductive outcomes was found. WHAT IS KNOWN ALREADY: CD has been associated with several conditions influencing female reproduction and pregnancy outcomes including spontaneous abortion and stillbirth...
June 15, 2018: Human Reproduction
Kurt Hanevik, Elisabeth Wik, Nina Langeland, Trygve Hausken
Markers of celiac disease (CeD) may be elevated in various conditions of intestinal inflammation or autoimmune disease. Recent reports argue that intestinal infection may induce development of CeD in susceptible individuals. Serum anti-tissue transglutaminase (tTG) and anti-endomysium antibodies (EMA) have been proposed in previous reports to be helpful in differentiating between giardiasis and CeD. In this report, we describe eight cases with elevated CeD serological markers and pathological duodenal histology during, or shortly after, Giardia infection...
June 16, 2018: Scandinavian Journal of Gastroenterology
Rishi Bolia, Anshu Srivastava, Aditya Kapoor, Surender Kumar Yachha, Ujjal Poddar
INTRODUCTION: We assessed cardiac function (CF) in celiac disease (CD) patients and the effect of gluten-free diet (GFD) on CF. METHODS: Prospective evaluation of CF using conventional and tissue doppler echocardiography in 50 CD patients (age 4.2 ± 1.1 years) at diagnosis and after a year of GFD (group 1), 100 CD children (group 2; 47 compliant and 53 non-compliant) in follow-up and 25 healthy controls. RESULTS: Untreated CD (n = 50) children had larger left ventricle end diastolic dimension (35...
June 16, 2018: Scandinavian Journal of Gastroenterology
Hai-Tao Wang, Zhi-Hai Yu, Can Tu, Bin Lu
RATIONALE: Isolated dissection of the celiac artery (IDCA) is one of isolated visceral artery dissection, which can occur alone, and can also be complicated with superior mesenteric artery dissection and splenic artery pseudoaneurysm. This disease is very rare in clinic. The exact pathogenesis of IDCA remains unknown. At present, no consensus has yet been reached on the best treatment strategy for this rare disease. In the present study, the clinical data of one IDCA patient diagnosed and treated in our hospital was retrospectively analyzed, and related literatures were reviewed, in order to improve the understanding of the disease...
June 2018: Medicine (Baltimore)
Donald Duerksen, Maria Ines Pinto-Sanchez, Alexandra Anca, Joyce Schnetzler, Shelley Case, Jenni Zelin, Adrianna Smallwood, Justine Turner, Elena Verdú, J Decker Butzner, Mohsin Rashid
OBJECTIVE: To describe clinical issues related to bone health in patients with celiac disease (CD) and to provide guidance on monitoring bone health in these patients. SOURCES OF INFORMATION: A PubMed search was conducted to review literature relevant to CD and bone health, including guidelines published by professional gastroenterological organizations. MAIN MESSAGE: Bone health can be negatively affected in both adults and children with CD owing to the inflammatory process and malabsorption of calcium and vitamin D...
June 2018: Canadian Family Physician Médecin de Famille Canadien
Hilary Jericho, Stefano Guandalini
The aim of this literature review is to discuss the extra-intestinal manifestations of celiac disease within the pediatric celiac population.
June 12, 2018: Nutrients
Anette Tønnes Pedersen, Line Cleemann, Katharina M Main, Anders Juul
Hypogonadism may be suspected if puberty is delayed. Pubertal delay may be caused by a normal physiological variant, by primary ovarian insufficiency (Turner syndrome), or reflect congenital hypogonadotropic hypogonadism (HH; genetic) or acquired HH (brain lesions). Any underlying chronic disease like inflammatory bowel disease, celiac disease, malnutrition (anorexia or orthorexia), or excessive physical activity may also result in functional HH. Thus, girls with delayed puberty should be evaluated for an underlying pathology before any treatment, including oral contraception, is initiated...
2018: Endocrine Development
Amanda Liu, Margaret Marcon, Esther Assor, Farid H Mahmud, Justine Turner, Diana Mager
The study purpose was to describe dietary intake and the factors influencing micronutrient supplements (MS) use in Celiac Disease (CD) ± Type 1 Diabetes (T1D). Three-day food records collected from parents of youth (3-18 years) with CD (n = 14) ± T1D (n = 10) were assessed for macro and micronutrient intake, diet quality (DQ), glycemic index (GI), glycemic load (GL), and food group intake. Focus group methodology and thematic concept analysis were conducted to determine factors influencing adolescent MS use...
June 12, 2018: Canadian Journal of Dietetic Practice and Research
Sara Ebrahimi, Gholamreza Khademi, Seyed Ali Jafari, Nona Zaboli Nejad, Abdolreza Norouzy, Bahareh Imani
Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian female neonate presented with severe bloody diarrhea, poor feeding, abdominal distention, and dehydration suggesting severe proctocolitis due to an allergy to the protein in cow's milk...
May 2018: Iranian Journal of Medical Sciences
Georgina Rubal-Peace, Caroline Sepp
No abstract text is available yet for this article.
June 5, 2018: Journal of the Academy of Nutrition and Dietetics
Annalise N vonderEmbse, Jamie C DeWitt
Immune-based childhood diseases and conditions, including allergic diseases and asthma, recurrent otitis media, pediatric celiac disease, and type 1 diabetes have been on the rise over the past decades. As a result, the use of developmental immunotoxicity (DIT) testing to identify potential environmental risk factors contributing to these and other diseases has become a priority for scientists across sectors. This chapter serves to provide insight into the scientific basis for DIT and determining the necessity of DIT testing and offers recommendations for DIT testing parameters to optimize sensitivity, power, and concordance among DIT assays...
2018: Methods in Molecular Biology
Valma Fuchs, Kalle Kurppa, Heini Huhtala, Markku Mäki, Leila Kekkonen, Katri Kaukinen
Background: Celiac disease is challenging to recognize, predisposing to long diagnostic delay. Currently, associated factors and significance of the delay remain obscure. Objective: The objective of this article is to investigate associated sociodemographic risk factors and health consequences of diagnostic delay in celiac disease. Methods: Altogether 611 patients were surveyed at diagnosis and after one year on a gluten-free diet regarding sociodemographic variables, well-being and use of medicines and health care services...
May 2018: United European Gastroenterology Journal
Sarah Moretti, Simona Mrakic-Sposta, Leda Roncoroni, Alessandra Vezzoli, Cinzia Dellanoce, Erika Monguzzi, Federica Branchi, Francesca Ferretti, Vincenza Lombardo, Luisa Doneda, Alice Scricciolo, Luca Elli
INTRODUCTION: High levels of reactive oxygen species (ROS) and impaired antioxidant defense systems lead to oxidative stress (OxS) and tissue injury in different intestinal and extra intestinal conditions, including celiac disease (CD). The aim of the present study was to investigate the role and potential use of ROS and other biomarkers of OxS in the clinical management of CD. METHODS: We collected duodenal specimens and blood samples from naïve patients (N-CD), patients on a gluten free diet (GFD) including responders (CD-GFD) and non-responders (NRCD)...
June 8, 2018: Clinical and Translational Gastroenterology
Fardin Yousefshahi, Mamak Tahmasebi
This case report presents a 55 years old man, presented with abdominal pain and diagnosed with a metastatic pancreatic tumor, who developed long lasting orthostatic hypotension and constipation following a celiac plexus block.
February 2018: Anesthesiology and Pain Medicine
Konstantinos Spanos, Myrto Theodorakopoulou, E Sebastian Debus, Fiona Rohlffs, Franziska Heidemann, Tilo Kölbel, Nikolaos Tsilimparis
PURPOSE: To evaluate the orientation of the standardized off-the-shelf multibranched t-Branch after implantation in urgent thoracoabdominal aortic aneurysm (TAAA) repairs, to characterize the impact of branch malorientation on procedural success, and to identify any predictive factors associated with malorientation. METHODS: A retrospective analysis was conducted of 42 consecutive patients (mean age 73.3±7 years; 25 men) with urgent TAAA presentation treated with the t-Branch from January 2014 to June 2017...
June 1, 2018: Journal of Endovascular Therapy
Supatcha Prasertcharoensuk, Narongchai Wongkonkitsin, Parichat Tunmit, Su-A-Pa Theeragul, Anucha Ahooja
Introduction . Infected aortoiliac aneurysms are rare, representing only 1% to 2% of all aortic aneurysms; we present a case of infected suprarenal aortic aneurysm with a nearly occluded celiac artery and superior mesenteric artery treated using an endovascular technique to preserve collateral in the retroperitoneal space from the inferior mesenteric artery for supplying visceral organs.
2018: Case Reports in Vascular Medicine
Gergely Bodis, Victoria Toth, Andreas Schwarting
The aim of this review is to provide a brief overview of the role and current clinical relevance of HLA-B27 in spondyloarthritis and HLA-B51 in Behcet's disease as well as HLA-DQ2/DQ8 in celiac disease and HLA-DRB1 in rheumatoid arthritis and to discuss possible future implications.
2018: Methods in Molecular Biology
Brian P McAllister, Emmanuelle Williams, Kofi Clarke
Celiac disease is a complex immune-mediated gluten-sensitive enteropathy with protean clinical manifestations. It is manifest in genetically predisposed individuals who ingest gluten in varying amounts. In broad terms, it is thought to affect 1% of the population in the USA. More specifically, the prevalence increases drastically from 1:133 in patients not-at-risk, to 1:56 in symptomatic patients, to 1:39 in patients with a second-degree relative with the diagnosis, and to 1:22 in patients with a first-degree relative with the diagnosis...
June 2, 2018: Clinical Reviews in Allergy & Immunology
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