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Anal cancer recurrence

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https://www.readbyqxmd.com/read/29742689/total-robotic-surgery-for-pancreaticoduodenectomy-combined-with-rectal-cancer-anterior-resection-a-case-report-and-literature-review
#1
QunGuang Jiang, TaiYuan Li, DongNing Liu, Cheng Tang
RATIONALE: Synchronous double malignancies, including carcinoma of the ampulla of Vater and rectal carcinoma, are generally uncommon occurrences in the gastrointestinal tract. PATIENT CONCERNS: The present study report a case of a 37-year-old man who was incidentally found to suffer from carcinoma of the ampulla of Vater and rectal carcinoma. DIAGNOSES: The duodenoscopy was performed and revealed an ulcerated and bulky ampulla of Vater, the biopsy from which revealed a moderate-differentiated adenocarcinoma, A local hospital colonoscopy confirmed a tumor located in rectal 7 cm from the anal margin and biopsy-confirmed poorly differentiated adenocarcinoma...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29717372/combined-repeat-laparoscopy-and-transanal-endolumenal-repair-hybrid-approach-in-the-early-management-of-postoperative-colorectal-anastomotic-leaks-technique-and-outcomes
#2
William Tzu-Liang Chen, Saurabh Bansal, Tao-Wei Ke, Sheng-Chi Chang, Yu-Chun Huang, Takashi Kato, Hwei-Ming Wang, Abe Fingerhut
BACKGROUND: Few clear recommendations exist for the management of colorectal anastomotic leaks, often based on surgeon preferences or institutional protocols. The primary goal was to evaluate the feasibility and safety of the combined laparoscopic and transanal (hybrid) approach to treat postoperative colorectal anastomotic leaks. The secondary goals included comparison of outcomes following early (< 5 days after initial resection) versus late (≥ 5 days) detection of leaks...
May 1, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29714663/assessment-of-bowel-and-anal-sphincter-function-after-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#3
Consuelo Rosa, Monica Di Tommaso, Luciana Caravatta, Annamaria Vinciguerra, Antonietta Augurio, Francesca Perrotti, Albina Allajbej, Marco Regoli, Isaia Al Zecca, Marta Di Nicola, Domenico Genovesi
PURPOSE: To report long-term effects on anorectal function and bowel disorders and late toxicity rate of preoperative chemoradiotherapy in patients with locally advanced rectal cancer. METHODS: Between 2000 and 2016, 201 patients treated with different neoadjuvant schedules of chemotherapy and radiotherapy doses were retrospectively analyzed. The Memorial Sloan-Kettering Cancer Center score was used for the evaluation of anal sphincter function. RESULTS: The median follow-up time was 68 months (interquartile range 35-113 months)...
April 1, 2018: Tumori
https://www.readbyqxmd.com/read/29693307/trans-anal-total-mesorectal-excision-is-it-really-safe-and-better-than-laparoscopic-total-mesorectal-excision-with-perineal-approach-first-in-patients-with-low-rectal-cancer-a-learning-curve-with-case-matched-study-in-68-patients
#4
Diane Mege, Elisabeth Hain, Zaher Lakkis, Léon Maggiori, Justine Prost À la Denise, Yves Panis
AIM: To compare learning curve of trans-anal total mesorectal excision (TATME) with laparoscopic TME started by perineal approach (LTME). METHOD: The first 34 consecutive patients who underwent TATME for low rectal cancer were matched with LTME performed by the same surgeon, for gender, body mass index and chemoradiation. RESULTS: 34 patients undergoing TATME (23 males; 58±14 years) were matched with 34 undergoing LTME (23 males; 59±13 years)...
April 25, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29691737/salvage-abdominoperineal-resection-for-squamous-cell-anal-cancer-a-30-year-single-institution-experience
#5
J A W Hagemans, S E Blinde, J J Nuyttens, W G Morshuis, M A M Mureau, J Rothbarth, C Verhoef, J W A Burger
BACKGROUND: Failure of chemoradiotherapy (CRT) for anal squamous cell carcinoma (SCC) results in persistent or recurrent anal SCC. Treatment with salvage abdominoperineal resection (APR) can potentially achieve cure. The aims of this study are to analyze oncological and surgical outcomes of our 30-year experience with salvage APR for anal SCC after failed CRT and identify prognostic factors for overall survival (OS). METHODS: All consecutive patients who underwent salvage APR between 1990 and 2016 for histologically confirmed persistent or recurrent anal SCC after failed CRT were retrospectively analyzed...
April 24, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29682714/-factors-associated-with-anastomotic-leakage-after-anterior-resection-in-rectal-cancer
#6
Kai Deng, Jianli Zhang, Xiuli Jiang, Shuai Feng
OBJECTIVE: To investigate the factors associated with the anastomotic leakage after anterior resection in rectal cancer. METHODS: From January 2014 to January 2017 471 patients underwent Dixon procedure for rectal cancer in The Affiliated Hospital of Qingdao University. The data of those patients was collected and reviewed retrospectively. Inclusion criteria included: 1) rectal cancer confirmed by preoperative electron colonoscopy; 2) the standard of total mesorectal excision followed by the surgeon during the surgery; and 3) elective surgery...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29678529/total-mesorectal-excision-versus-local-excision-after-preoperative-chemoradiotherapy-in-rectal-cancer-with-lymph-node-metastasis-a-propensity-score-matched-analysis
#7
Young Seob Shin, Jin-Hong Park, Sang Min Yoon, Jin Cheon Kim, Chang Sik Yu, Seok-Byung Lim, In Ja Park, Tae Won Kim, Yong Sang Hong, Kyu-Pyo Kim, Eun Kyung Choi, Seung Do Ahn, Sang-Wook Lee, Jong Hoon Kim
PURPOSE: To determine whether local excision (LE) outcomes were comparable to total mesorectal excision (TME) outcomes in node-positive (cN+) rectal cancer patients who were good responders. METHODS AND MATERIALS: This retrospective study included clinical T2-3 and cN+ low rectal cancer patient who received preoperative chemoradiotherapy (PCRT) followed by TME or LE. Clinical stage T1 or T4 tumors, upper-to-middle rectal tumors (>7 cm from anal verge), and synchronous distant metastases were excluded...
March 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29650925/-a-case-of-colon-cancer-with-brain-liver-and-lung-metastasis-successfully-treated-with-bevacizumab-plus-xelox-therapy
#8
Tomokazu Tokoro, Keishi Nakamura, Atsushi Hirose, Shinichi Nakanuma, Kohichi Okamoto, Jun Kinoshita, Isamu Makino, Hironori Hayashi, Katsunobu Oyama, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
The patient was a 57-year-old woman. Preclinical examination of malignant lymphoma revealed 0-I sp type of early rectal cancer in the upper rectum, 20 cm from the anal margin. Endoscopic mucosal resection was performed and positive deep margins were pathologically diagnosed. Additional intestinal resection with lymph node dissection was deemed necessary, but ABVD therapy was initiated because the clinical stage of the malignant lymphoma was Stage III b or higher. Two months after detecting elevated CEA, S8 liver metastasis was pointed out, and examination of weakness of the right upper limb revealed nodular, multifocal brain metastasis...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650913/-a-case-of-laparoscopic-hartmann-s-operation-for-perforation-of-rectal-cancer-in-superior-elderly-people
#9
Tomohito Sakai, Koji Soga, Toru Mizutani, Shunji Kato, Shouji Hirashima, Minoru Nishio, Toshimori Koh, Atsushi Oguro, Noboru Nakagawa
We report a case where home discharge was possible after laparoscopic Hartmann's operation for superior elderly perforation of rectal cancer. The patient was 91-year-old, a woman. She was delivered to the emergency room complaining of weakness. We diagnosed rectal perforation and started emergency laparoscopic surgery. Rectal cancer perforation was observed during surgery and laparoscopic Hartmann's operation plus D2 lymph node dissection was performed. The operation time was 3 hours 21 minutes, the blood loss was 10 g...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650851/-a-case-of-isolated-lateral-pelvic-lymph-node-recurrence-after-tme-for-early-lower-rectal-cancer-treated-with-laparoscopic-lateral-lymph-node-dissection
#10
Ryuichiro Kimura, Masayoshi Yasui, Masayuki Ohue, Yusuke Takahashi, Norikatsu Miyoshi, Yoshitomo Yanagimoto, Keijiro Sugimura, Akira Tomokuni, Hirofumi Akita, Moon Jeong-Ho, Shogo Kobayashi, Hidenori Takahashi, Takeshi Omori, Yoshiyuki Fujiwara, Hiroshi Miyata, Masahiko Yano, Masato Sakon
There are no established treatment protocol for isolated lateral lymph node recurrence in patients with T1 lower rectal cancer, because such case is very rare. In our institution, this is the only recorded case of lateral node recurrence post-resection. It has been documented in several studies that salvage surgery for colorectal cancer improves prognosis. However, there were only 3 reported cases found for lateral lymph node metastasis from colorectal cancer that underwent excision. In this study, we report a rare case of lateral lymph node recurrence after trans-anal resection for T1 lower rectal cancer wherein we performed laparoscopic right lateral pelvic lymph node dissection...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29629355/risk-factors-of-stoma-re-creation-after-closure-of-diverting-ileostomy-in-patients-with-rectal-cancer-who-underwent-low-anterior-resection-or-intersphincteric-resection-with-loop-ileostomy
#11
Ook Song, Kyung Hwan Kim, Soo Young Lee, Chang Hyun Kim, Young Jin Kim, Hyeong Rok Kim
Purpose: The aim of this study was to identify the risk factors of stoma re-creation after closure of diverting ileostomy in patients with rectal cancer who underwent low anterior resection (LAR) or intersphincteric resection (ISR) with loop ileostomy. Methods: We retrospectively reviewed 520 consecutive patients with rectal cancer who underwent LAR or ISR with loop ileostomy from January 2005 to December 2014 at Chonnam National University Hwasun Hospital. Risk factors for stoma re-creation after ileostomy closure were evaluated...
April 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29623585/the-effect-of-dose-escalation-for-large-squamous-cell-carcinomas-of-the-anal-canal
#12
R N Prasad, J Elson, J Kharofa
PURPOSE: Chemoradiation allows for organ preservation in patients with anal cancer, but patients with large tumors (> 5 cm) have elevated rates of locoregional recurrence. With conformal radiation techniques, there is interest in dose escalation to decrease local recurrence in patients with large tumor size. METHODS/PATIENTS: The National Cancer Database (NCDB) was used to identify patients with anal cancer from 2004 to 2013 with tumors > 5 cm. Adult patients who received definitive chemoradiation were included...
April 5, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29594584/genital-marginal-failures-after-intensity-modulated-radiation-therapy-imrt-in-squamous-cell-anal-cancer-no-higher-risk-with-imrt-when-compared-to-3dcrt
#13
V Dell'Acqua, J Kobiela, F Kraja, M C Leonardi, A Surgo, M A Zerella, S Arculeo, C Fodor, R Ricotti, M G Zampino, S Ravenda, G Spinoglio, R Biffi, A Bazani, R Luraschi, S Vigorito, P Spychalski, R Orecchia, R Glynne-Jones, B A Jereczek-Fossa
Intensity-modulated radiotherapy (IMRT) is considered the preferred option in squamous cell canal cancer (SCAC), delivering high doses to tumor volumes while minimizing dose to surrounding normal tissues. IMRT has steep dose gradients, but the technique is more demanding as deep understanding of target structures is required. To evaluate genital marginal failure in a cohort of patients with non-metastatic SCAC treated either with IMRT or 3DCRT and concurrent chemotherapy, 117 patients with SCAC were evaluated: 64 and 53 patients were treated with IMRT and 3DCRT techniques, respectively...
March 28, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29573536/outcome-of-surgery-for-recurrent-anal-cancer-results-from-a-tertiary-referral-centre
#14
M Bignell, H Chave, G Branagan
AIM: Chemoradiotherapy remains the first line treatment for anal cancer with surgery reserved for cancer recurrence or persistence. The low incidence of anal cancer means the numbers undergoing surgery is small with centralization for excision to regional cancer centres. We present our experience of abdominal perineal excision, with reconstruction of the perineal defect (APERR), within a tertiary centre. METHOD: Over a fifteen year period data were collected retrospectively from notes of patients who underwent an APERR...
March 24, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29559074/-work-up-and-treatment-of-anal-cancer
#15
Anna-Camilla Ellemann, Eva Serup-Hansen
The incidence of anal cancer is increasing. The primary treatment consists of radiotherapy concomitant with chemotherapy. Short- and long-term side effects are common, and supportive care during treatment and rehabilitation after treatment is necessary. Locoregional recurrence is treated with an abdominoperineal resection with sigmoideostomia and/or lymph node exairesis. Staging and treatment is done centralized. The prognosis has improved over the latest 10-20 years with a long-term overall survival of > 70% after primary therapy and approximately 50% after surgical treatment for recurrence...
March 19, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29532208/the-fate-of-preserved-sphincter-in-rectal-cancer-patients
#16
Ri Na Yoo, Gun Kim, Bong-Hyeon Kye, Hyeon-Min Cho, HyungJin Kim
PURPOSE: Sphincter-saving surgery is widely accepted operative modality to treat rectal cancer. It often requires temporary diverting stoma to avoid the complications of anastomotic failure. This study investigates the cumulative failure rate in sphincter preservation for rectal cancer and the risk factors associated with the permanent stoma. METHODS: A retrospective study on 358 patients diagnosed with primary rectal cancer from 2009 to 2013 was conducted at a single institute...
June 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29506843/pathologic-response-following-treatment-for-locally-advanced-rectal-cancer-does-location-matter
#17
William H Ward, Elin R Sigurdson, Andrew C Esposito, Karen J Ruth, Samuel M Manstein, Eric C Sorenson, Brian D Wernick, Jeffrey M Farma
BACKGROUND: Despite advances in the treatment of rectal adenocarcinoma, the management of locally advanced disease remains a challenge. The standard of care for patients with stages II and III rectal cancer includes neoadjuvant chemoradiation followed by total mesorectal excision and postoperative chemotherapy. Much effort has been dedicated to the identification of predictive factors associated with pathologic complete response (pCR). The aim of our study was to examine our institutional experience and determine whether any association exists between anatomic tumor location and the rate of pCR...
April 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29473452/a-new-surgical-device-for-anterograde-intraoperative-rectal-washout
#18
Fabio Rondelli, Roberto Santinelli, Paolo Stella, Walter Bugiantella, Graziano Ceccarelli, Ruben Carlo Balzarotti, Michele De Rosa, Nicola Avenia
BACKGROUND: Colorectal cancer is the fourth most diffuse cause of death in the world and local recurrence is associated with a reduced long-term life expectancy, with a reduced quality of life. Rectal washout at the anastomosis site leads to a statistically significant reduction of local recurrences. METHODS: We developed the idea of a new laparoscopic stapler with an integrated washout system that could decontaminate the rectal stump before resection, without the need to enlarge the standard surgical incision or even to distort the incision site, closing the rectal stump just below the inferior part of the cancer, and then proceeding with the resection and stapling of the distal part of the tumor...
February 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29416628/exome-sequencing-reveals-aberrant-signalling-pathways-as-hallmark-of-treatment-naive-anal-squamous-cell-carcinoma
#19
Wulfran Cacheux, Virginie Dangles-Marie, Etienne Rouleau, Julien Lazartigues, Elodie Girard, Adrien Briaux, Pascale Mariani, Sophie Richon, Sophie Vacher, Bruno Buecher, Marion Richard-Molard, Emmanuelle Jeannot, Nicolas Servant, Fereshteh Farkhondeh, Odette Mariani, Thomas Rio-Frio, Sergio Roman-Roman, Emmanuel Mitry, Ivan Bieche, Astrid Lièvre
Anal squamous cell carcinomas (ASCC) are rare tumours in humans. The etiological role of HPV infection is now well established but little is known about the molecular landscape and signalling pathways involved in the pathogenesis of this cancer. Here we report the results from a whole exome sequencing of a homogeneous group of 20 treatment-naive ASCC. A total of 2422 somatic single nucleotide variations (SNV) were found, with an overall moderate rate of somatic mutations per tumour (median: 105 relevant SNV per tumour) but a high mutational load in 3 tumours...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414633/the-impact-of-rectal-cancer-tumor-height-on-recurrence-rates-and-metastatic-location-a-competing-risk-analysis-of-a-national-database
#20
Knut M Augestad, Deborah S Keller, Paul M Bakaki, Johnie Rose, Siran M Koroukian, Tom Øresland, Conor P Delaney
BACKGROUND: The impact of rectal cancer tumor height on local recurrence and metastatic spread is unknown. The objective was to evaluate the impact of rectal cancer tumor height from the anal verge on metastatic spread and local recurrence patterns. METHODS: The Norwegian nationwide surgical quality registry was reviewed for curative rectal cancer resections from 1/1/1996-12/15/2006. Cancers were stratified into five height groups: 0-3 cm, >3-5 cm, >5-9 cm, >9-12 cm, 12 cm-HI...
April 2018: Cancer Epidemiology
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