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https://www.readbyqxmd.com/read/28926565/a-snp-panel-and-online-tool-for-checking-genotype-concordance-through-comparing-qr-codes
#1
Yonghong Du, Joshua S Martin, John McGee, Yuchen Yang, Eric Yi Liu, Yingrui Sun, Matthias Geihs, Xuejun Kong, Eric Lingfeng Zhou, Yun Li, Jie Huang
In the current precision medicine era, more and more samples get genotyped and sequenced. Both researchers and commercial companies expend significant time and resources to reduce the error rate. However, it has been reported that there is a sample mix-up rate of between 0.1% and 1%, not to mention the possibly higher mix-up rate during the down-stream genetic reporting processes. Even on the low end of this estimate, this translates to a significant number of mislabeled samples, especially over the projected one billion people that will be sequenced within the next decade...
2017: PloS One
https://www.readbyqxmd.com/read/28922089/the-jolly-fat-effect-in-middle-aged-korean-women
#2
Gyeyoon Yim, Younjhin Ahn, Juhee Cho, Yoosoo Chang, Seungho Ryu, Joong-Yeon Lim, Hyun-Young Park
BACKGROUND: It has been hypothesized that depression and obesity are bi-directionally associated, and when overweight people appear to show a lower risk of depression, this supports the "Jolly Fat" hypothesis. The aim of this study was to examine the "Jolly Fat" hypothesis in middle-aged women in Korea, by different perceived stress levels. METHODS: We performed a cross-sectional study of 44 to 56 aged Korean women (n = 2201) who underwent a health check-up program at the healthcare centers of Kangbuk Samsung Hospital (Seoul and Suwon centers) in Korea...
September 18, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28898390/comprehensive-geriatric-assessment-for-older-adults-admitted-to-hospital
#3
REVIEW
Graham Ellis, Mike Gardner, Apostolos Tsiachristas, Peter Langhorne, Orlaith Burke, Rowan H Harwood, Simon P Conroy, Tilo Kircher, Dominique Somme, Ingvild Saltvedt, Heidi Wald, Desmond O'Neill, David Robinson, Sasha Shepperd
BACKGROUND: Comprehensive geriatric assessment (CGA) is a multi-dimensional, multi-disciplinary diagnostic and therapeutic process conducted to determine the medical, mental, and functional problems of older people with frailty so that a co-ordinated and integrated plan for treatment and follow-up can be developed. This is an update of a previously published Cochrane review. OBJECTIVES: We sought to critically appraise and summarise current evidence on the effectiveness and resource use of CGA for older adults admitted to hospital, and to use these data to estimate its cost-effectiveness...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28886739/an-australian-general-practice-based-strategy-to-improve-chronic-disease-prevention-and-its-impact-on-patient-reported-outcomes-evaluation-of-the-preventive-evidence-into-practice-cluster-randomised-controlled-trial
#4
Mark Fort Harris, Sharon M Parker, John Litt, Mieke van Driel, Grant Russell, Danielle Mazza, Upali W Jayasinghe, Jane Smith, Chris Del Mar, Riki Lane, Elizabeth Denney-Wilson
BACKGROUND: Implementing evidence-based chronic disease prevention with a practice-wide population is challenging in primary care. METHODS: PEP Intervention practices received education, clinical audit and feedback and practice facilitation. Patients (40‑69 years) without chronic disease from trial and control practices were invited to participate in baseline and 12 month follow up questionnaires. Patient-recalled receipt of GP services and referral, and the proportion of patients at risk were compared over time and between intervention and control groups...
September 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28883276/acute-exacerbation-of-organizing-pneumonia-leading-to-sudden-death-in-a-patient-with-sarcoidosis-lymphoma-syndrome
#5
Kazuhide Iizuka, Jun Ando, Azuchi Masuda, Tomonori Ochiai, Ran Tomomasa, Hajime Yasuda, Tomoiku Takaku, Yasunori Ota, Takashi Yao, Akihiko Gotoh, Norio Komatsu
The subject was an 83-year-old female; she had a history of Propionibacterium acnes-related sarcoidosis at the age of 79 years. At diagnosis, she was treated with clarithromycin and achieved remission. Four years later, during a routine physical check-up, she presented with pulmonary opacities and swelling of multiple lymph nodes. A definitive diagnosis of lymphoma could not be made by inguinal lymph node biopsy. The patient's general condition was good, and we observed her clinical course. Oh the 56th day of her illness, she died suddenly...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28873069/fred-a-gpu-accelerated-fast-monte-carlo-code-for-rapid-treatment-plan-recalculation-in-ion-beam-therapy
#6
A Schiavi, M Senzacqua, S Pioli, A Mairani, G Magro, S Molinelli, M Ciocca, G Battistoni, V Patera
Ion beam therapy is a rapidly growing technique for tumor radiation therapy. Ions allow for a high dose deposition in the tumor region, while sparing the surrounding healthy tissue. For this reason, the highest possible accuracy in the calculation of dose and its spatial distribution is required in treatment planning. On one hand, commonly used treatment planning software solutions adopt a simplified beam-body interaction model by remapping pre-calculated dose distributions into a 3D water-equivalent representation of the patient morphology...
September 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28851346/metachronous-solitary-splenic-metastasis-arising-from-early-gastric-cancer-a-case-report-and-literature-review
#7
Tsutomu Namikawa, Yasuhiro Kawanishi, Kazune Fujisawa, Eri Munekage, Masaya Munekage, Takahito Sugase, Hiromichi Maeda, Hiroyuki Kitagawa, Tatsuya Kumon, Makoto Hiroi, Michiya Kobayashi, Kazuhiro Hanazaki
BACKGROUND: The metastasis of malignant tumors to the spleen is rare, and only a small percentage of cases can be treated surgically, as splenic metastases generally occur in the context of multivisceral metastatic cancer at a terminal stage. We report a rare case of metachronous solitary splenic metastasis arising from early gastric cancer. CASE PRESENTATION: A 75-year-old man was initially referred to our hospital for examination of gastric cancer, diagnosed at a medical check-up...
August 29, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28836327/serum-sodium-level-within-the-normal-range-is-associated-with-maximum-voluntary-tongue-pressure-against-the-palate-among-community-dwelling-older-japanese-men
#8
Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Miho Higashi, Mako Nagayoshi, Koichiro Kadota, Shin-Ya Kawashiri, Noboru Takamura, Takahiro Maeda
AIM: Recent geriatric studies have focused on maximum voluntary tongue pressure against the palate (MTP) as a diagnostic value for dysphagia, as dysphagia causes aspiration pneumonia. Dysphagia can also cause water intake difficulties, resulting in hypernatremia by indicating the presence of hyperosmotic dehydration. However, no studies have reported on a possible association between reduced MTP and serum sodium levels. METHODS: To evaluate hyperosmotic dehydration within the normal range as an indicator of reduced MTP, we carried out a cross-sectional study of 655 older Japanese community-dwelling men (age ≥60 years) who undertook a general health check-up from 2015 to 2016...
August 23, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28831535/effect-of-population-screening-for-type-2-diabetes-and-cardiovascular-risk-factors-on-mortality-rate-and-cardiovascular-events-a-controlled-trial-among-1-912-392-danish-adults
#9
Rebecca K Simmons, Simon J Griffin, Daniel R Witte, Knut Borch-Johnsen, Torsten Lauritzen, Annelli Sandbæk
AIMS/HYPOTHESIS: Health check programmes for chronic disease have been introduced in a number of countries. However, there are few trials assessing the benefits and harms of these screening programmes at the population level. In a post hoc analysis, we evaluated the effect of population-based screening for type 2 diabetes and cardiovascular risk factors on mortality rates and cardiovascular events. METHODS: This register-based, non-randomised, controlled trial included men and women aged 40-69 years without known diabetes who were registered with a general practice in Denmark (n = 1,912,392)...
August 23, 2017: Diabetologia
https://www.readbyqxmd.com/read/28830396/missed-opportunities-in-the-evaluation-of-public-health-interventions-a-case-study-of-physical-activity-programmes
#10
Sarah Hanson, Andy Jones
BACKGROUND: Evidence-based approaches are requisite in evaluating public health programmes. Nowhere are they more necessary than physical activity interventions where evidence of effectiveness is often poor, especially within hard to reach groups. Our study reports on the quality of the evaluation of a government funded walking programme in five 'Walking Cities' in England. Cities were required to undertake a simple but robust evaluation using the Standard Evaluation Framework (SEF) for physical activity interventions to enable high quality, consistent evaluation...
August 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28823111/welfare-to-work-interventions-and-their-effects-on-the-mental-and-physical-health-of-lone-parents-and-their-children
#11
REVIEW
Marcia Gibson, Hilary Thomson, Kasia Banas, Vittoria Lutje, Martin J McKee, Susan P Martin, Candida Fenton, Clare Bambra, Lyndal Bond
BACKGROUND: Lone parents in high-income countries have high rates of poverty (including in-work poverty) and poor health. Employment requirements for these parents are increasingly common. 'Welfare-to-work' (WtW) interventions involving financial sanctions and incentives, training, childcare subsidies and lifetime limits on benefit receipt have been used to support or mandate employment among lone parents. These and other interventions that affect employment and income may also affect people's health, and it is important to understand the available evidence on these effects in lone parents...
August 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28814583/does-use-of-point-of-care-testing-improve-cost-effectiveness-of-the-nhs-health-check-programme-in-the-primary-care-setting-a-cost-minimisation-analysis
#12
Austen El-Osta, Maria Woringer, Elena Pizzo, Talitha Verhoef, Claire Dickie, Melody Z Ni, Jeremy R Huddy, Michael Soljak, George B Hanna, Azeem Majeed
OBJECTIVE: To determine if use of point of care testing (POCT) is less costly than laboratory testing to the National Health Service (NHS) in delivering the NHS Health Check (NHSHC) programme in the primary care setting. DESIGN: Observational study and theoretical mathematical model with microcosting approach. SETTING: We collected data on NHSHC delivered at nine general practices (seven using POCT; two not using POCT). PARTICIPANTS: We recruited nine general practices offering NHSHC and a pathology services laboratory in the same area...
August 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28814219/coeliac-disease-review-of-diagnosis-and-management
#13
REVIEW
Marjorie M Walker, Jonas F Ludvigsson, David S Sanders
Coeliac disease is an immune-mediated systemic disease triggered by exposure to gluten, and manifested by small intestinal enteropathy and gastrointestinal and extra-intestinal symptoms. Recent guidelines recommend a concerted use of clear definitions of the disease. In Australia, the most recent estimated prevalence is 1.2% in adult men (1:86) and 1.9% in adult women (1:52). Active case finding is appropriate to diagnose coeliac disease in high risk groups. Diagnosis of coeliac disease is important to prevent nutritional deficiency and long term risk of gastrointestinal malignancy...
August 21, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28809367/root-caries-analysis-in-working-population-of-35-44-years-of-age-spain
#14
C Saura-Moreno, M-V Cortés-Arcas, A Fernández-Meseguer, E Calvo-Bonacho, J-C Llodra-Calvo
BACKGROUND: The aim of this study was to analyse the influence of socio-demographic variables, toothbrushing frequency, frequency of snacking between meals, and tobacco and alcohol consumption, in root caries in the Spanish working population of Valencia and Murcia regions. MATERIAL AND METHODS: Cross sectional study of 458 workers 35-44 years of age, who underwent a routine work-related check-up, from June 2009 to April 2010, and were also examined, following the WHO methodology, by a calibrated dentist...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28801437/patient-experience-of-nhs-health-checks-a-systematic-review-and-qualitative-synthesis
#15
Juliet A Usher-Smith, Emma Harte, Calum MacLure, Adam Martin, Catherine L Saunders, Catherine Meads, Fiona M Walter, Simon J Griffin, Jonathan Mant
OBJECTIVE: To review the experiences of patients attending NHS Health Checks in England. DESIGN: A systematic review of quantitative and qualitative studies with a thematic synthesis of qualitative studies. DATA SOURCES: An electronic literature search of Medline, Embase, Health Management Information Consortium, Cumulative Index of Nursing and Allied Health Literature, Global Health, PsycInfo, Web of Science, OpenGrey, the Cochrane Library, National Health Service (NHS) Evidence, Google Scholar, Google, Clinical Trials...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801302/improving-patient-centered-care-for-young-people-in-general-practice-with-a-codesigned-screening-app-mixed-methods-study
#16
Marianne Julie Webb, Greg Wadley, Lena Amanda Sanci
BACKGROUND: Despite experiencing a high prevalence and co-occurrence of mental health disorders and health-compromising behaviors, young people tend not to seek professional help for these concerns. However, they do regularly attend primary care, making primary care providers ideally situated to identify and discuss mental health and lifestyle issues as part of young people's routine health care. OBJECTIVE: The aim was to investigate whether using a codesigned health and lifestyle-screening app, Check Up GP, in general practice influenced young people's assessment of the quality of their care (measures of patient-centered care and youth friendliness), and their disclosure of sensitive issues...
August 11, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28799142/what-to-do-in-failed-hemispherotomy-our-clinical-series-and-review-of-the-literature
#17
REVIEW
Andrea Bartoli, Y El Hassani, B Jenny, S Momjian, C M Korff, M Seeck, S Vulliemoz, K Schaller
Hemispherotomy is an established surgical technique to cure or palliate selected, mostly young patients suffering from refractory epilepsy. However, a few patients continue to have seizures despite the surgical hemispherical disconnection. We present a case series of patients who underwent redo hemispherotomy after a first unsuccessful hemispherical disconnection and provide a roadmap for subsequent workup and treatment. The institutional database of epilepsy surgery was reviewed. Twenty-four patients who underwent hemispherotomies for refractory epilepsy were identified between 2007 and 2016...
August 10, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28791064/validation-of-farsi-translation-of-the-ocular-surface-disease-index
#18
Farzad Pakdel, Mahmood Reza Gohari, Anis Sadat Jazayeri, Afsaneh Amani, Niloofar Pirmarzdashti, Hossein Aghaee
PURPOSE: To develop and validate a Farsi version of Ocular Surface Disease Index (OSDI) for the Iranian population. METHODS: This study was a translation and cross-cultural adaptation and validation of Farsi version of OSDI. Four bilingual (English-Persian) individual including three physicians and one native English teacher were asked to translate the original English OSDI questionnaire in Farsi. Following back and forth translation, integration and pilot check, the translation team came to consensus on translation...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28756618/antioxidant-vitamin-and-mineral-supplements-for-slowing-the-progression-of-age-related-macular-degeneration
#19
REVIEW
Jennifer R Evans, John G Lawrenson
BACKGROUND: It has been proposed that antioxidants may prevent cellular damage in the retina by reacting with free radicals that are produced in the process of light absorption. Higher dietary levels of antioxidant vitamins and minerals may reduce the risk of progression of age-related macular degeneration (AMD). OBJECTIVES: The objective of this review was to assess the effects of antioxidant vitamin or mineral supplementation on the progression of AMD in people with AMD...
July 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28756617/antioxidant-vitamin-and-mineral-supplements-for-preventing-age-related-macular-degeneration
#20
REVIEW
Jennifer R Evans, John G Lawrenson
BACKGROUND: There is inconclusive evidence from observational studies to suggest that people who eat a diet rich in antioxidant vitamins (carotenoids, vitamins C, and E) or minerals (selenium and zinc) may be less likely to develop age-related macular degeneration (AMD). OBJECTIVES: To determine whether or not taking antioxidant vitamin or mineral supplements, or both, prevent the development of AMD. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2017, Issue 2), MEDLINE Ovid (1946 to 29 March 2017), Embase Ovid (1947 to 29 March 2017), AMED (Allied and Complementary Medicine Database) (1985 to 29 March 2017), OpenGrey (System for Information on Grey Literature in Europe) (www...
July 30, 2017: Cochrane Database of Systematic Reviews
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