George-Călin Oprinca, Cosmin-Ioan Mohor, Alexandra Oprinca-Muja, Adrian Hașegan, Adrian-Nicolae Cristian, Sorin-Radu Fleacă, Ioana Boeraș, Roxana Cardoș, Diter Atasie, Manuela Mihalache, Cosmin Mihalache, Elena Teodora Tâlvan, Călin-Ilie Mohor
In this comprehensive study of 15 deceased patients with confirmed SARS-CoV-2 infection, spanning a time frame of 1 to 68 days from confirmation to death, autopsies were meticulously conducted with stringent safety measures. Clinical, laboratory, histopathological, and molecular analyses were integrated, shedding light on diverse pulmonary lesions, including acute inflammatory changes, vascular abnormalities, and aberrant regenerative processes. Immunohistochemical analysis, utilizing various markers, successfully identified the SARS-CoV-2 nucleocapsid antigen within infected tissue cells and also revealed what type of inflammatory cells are involved in COVID-19 pathogenesis...
February 24, 2024: Microorganisms