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https://www.readbyqxmd.com/read/28435075/development-of-oral-lyophilisates-containing-meloxicam-nanocrystals-using-qbd-approach
#1
Sonia Iurian, Cătălina Bogdan, Ioan Tomuță, Piroska Szabó-Révész, Anita Chvatal, Sorin E Leucuța, Mirela Moldovan, Rita Ambrus
The aim of this study was to develop oral lyophilisates with improved meloxicam (MEL) dissolution, optimizing each step of the preparation by design of experiments. First, meloxicam nanosuspensions were prepared by high-pressure homogenization (HPH), using PVP, Poloxamer or PEG as stabilizers and were subjected to freeze-drying using mannitol as cryoprotectant. The effects of the stabilizers and cryoprotectant were assessed and an optimal formulation was generated within the Design Space where the particle sizes and the PDIs are at their lowest values...
April 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28427734/comparison-of-outcomes-and-prognosis-of-patients-with-versus-without-newly-diagnosed-diabetes-mellitus-after-primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction-the-horizons-ami-study
#2
Konstanze Ertelt, Sorin J Brener, Roxana Mehran, Ori Ben-Yehuda, Thomas McAndrew, Gregg W Stone
A history of diabetes mellitus (DM) is an independent predictor for adverse events in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Outcomes of patients with STEMI and newly diagnosed DM (NDM) are less well described. We used the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial database to identify the outcomes at 30 days and 3 years according to no, known, and NDM in patients with STEMI...
March 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28426584/neuromuscular-monitoring-as-the-art-of-probability
#3
Mohamed Naguib, Franklin Dexter, Sorin J Brull
No abstract text is available yet for this article.
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28424987/assessment-of-the-lymph-node-status-in-patients-undergoing-liver-resection-for-intrahepatic-cholangiocarcinoma-the-new-eighth-edition-ajcc-staging-system
#4
Fabio Bagante, Gaya Spolverato, Matthew Weiss, Sorin Alexandrescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Oliver Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Timothy M Pawlik
INTRODUCTION: The role of routine lymphadenectomy for intrahepatic cholangiocarcinoma (ICC) is still controversial. The AJCC eighth edition recommends a minimum of six harvested lymph nodes (HLNs) for adequate nodal staging. We sought to define outcome and risk of death among patients who were staged with ≥6 HLNs versus <6 HLNs. MATERIALS AND METHODS: Patients undergoing hepatectomy for ICC between 1990 and 2015 at 1 of the 14 major hepatobiliary centers were identified...
April 19, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28424470/atom-size-electron-vortex-beams-with-selectable-orbital-angular-momentum
#5
Darius Pohl, Sebastian Schneider, Paul Zeiger, Ján Rusz, Peter Tiemeijer, Sorin Lazar, Kornelius Nielsch, Bernd Rellinghaus
The decreasing size of modern functional magnetic materials and devices cause a steadily increasing demand for high resolution quantitative magnetic characterization. Transmission electron microscopy (TEM) based measurements of the electron energy-loss magnetic chiral dichroism (EMCD) may serve as the needed experimental tool. To this end, we present a reliable and robust electron-optical setup that generates and controls user-selectable single state electron vortex beams with defined orbital angular momenta...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416102/synthesis-biochemical-evaluation-and-molecular-modeling-studies-of-aryl-and-arylalkyl-di-n-butyl-phosphates-effective-butyrylcholinesterase-inhibitors
#6
Kensaku Nakayama, Jason P Schwans, Eric J Sorin, Trina Tran, Jeannette Gonzalez, Elvis Arteaga, Sean McCoy, Walter Alvarado
A series of dialkyl aryl phosphates and dialkyl arylalkyl phosphates were synthesized. Their inhibitory activities were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The di-n-butyl phosphate series consistently displayed selective inhibition of BChE over AChE. The most potent inhibitors of butyrylcholinesterase were di-n-butyl-3,5-dimethylphenyl phosphate (4b) [KI=1.0±0.4μM] and di-n-butyl 2-naphthyl phosphate (5b) [KI=1.9±0.4μM]. Molecular modeling was used to uncover three subsites within the active site gorge that accommodate the three substituents attached to the phosphate group...
April 5, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28411373/impact-of-major-vascular-resection-on-outcomes-and-survival-in-patients-with-intrahepatic-cholangiocarcinoma-a-multi-institutional-analysis
#7
Bradley N Reames, Aslam Ejaz, Bas Groot Koerkamp, Sorin Alexandrescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Guillaume Martel, James Wallis Marsh, Timothy M Pawlik
BACKGROUND: Major vascular involvement (IVC or portal vein) for intrahepatic cholangiocarcinoma (ICC) has traditionally been considered a contraindication to resection. We sought to define perioperative outcomes and survival of ICC patients undergoing hepatectomy with major vascular resection in a large international multi-institutional database. METHODS: A total of 1087 ICC patients who underwent curative-intent hepatectomy between 1990 and 2016 were identified from 13 institutions...
April 15, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28409033/aborted-sudden-cardiac-death-in-a-female-patient-presenting-with-takotsubo-like-cardiomyopathy-due-to-epicardial-coronary-vasospasm
#8
Sorin Giusca, Tom Eisele, Peter Nunninger, Benedikt Münz, Grigorios Korosoglou
Takotsubo cardiomyopathy is characterized by apical ballooning of the left ventricle (LV) in the absence of relevant coronary artery stenosis, which typically occurs in elderly women after emotional stress. Catecholamine cardiotoxicity, metabolic disturbance, and coronary microvascular impairment have previously been proposed as underlying pathophysiologic mechanisms of takotsubo cardiomyopathy, whereas myocardial stunning resulting from epicardial coronary artery vasospasm is not generally accepted as a cause of takotsubo cardiomyopathy...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28388994/relation-of-baseline-hemoglobin-levels-and-adverse-events-in-patients-with-acute-coronary-syndromes-from-the-acute-catheterization-and-urgent-intervention-triage-strategy-and-harmonizing-outcomes-with-revascularization-and-stents-in-acute-myocardial-infarction
#9
Sorin J Brener, Roxana Mehran, George D Dangas, Edwin Magnus Ohman, Bernhard Witzenbichler, Yiran Zhang, Rupa Parvataneni, Gregg W Stone
The association between anemia at admission and adverse outcomes in patients with acute coronary syndrome (ACS) has been incompletely studied. Anemia was defined as serum hemoglobin <12 g/dl in women or <13 g/dl in men in 2 large trials of patients with ACS. We plotted hazard functions for major bleeding at 30 days and all-cause mortality, myocardial infarction, and stent thrombosis at 1 year according to baseline hemoglobin. Among 16,318 patients, 3070 (18.8%) had anemia at baseline. All-cause death at 1 year (2...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28381470/evidence-supporting-the-existence-of-a-distinct-obese-phenotype-of-heart-failure-with-preserved-ejection-fraction
#10
Masaru Obokata, Yogesh N V Reddy, Sorin V Pislaru, Vojtech Melenovsky, Barry A Borlaug
Background -Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Phenotyping patients into pathophysiologically homogenous groups may enable better targeting of treatment. Obesity is common in HFpEF and has many cardiovascular effects, suggesting it may be a viable candidate for phenotyping. We compared cardiovascular structure, function, and reserve capacity in subjects with obese HFpEF, non-obese HFpEF, and controls. Methods -Subjects with obese HFpEF (BMI≥35kg/m(2), n=99), non-obese HFpEF (BMI<30kg/m(2), n=96), and non-obese controls free of HF (n=71) underwent detailed clinical assessment, echocardiography and invasive hemodynamic exercise testing...
April 5, 2017: Circulation
https://www.readbyqxmd.com/read/28381375/superior-mesenteric-artery-first-approach-versus-standard-pancreaticoduodenectomy-a-systematic-review-and-meta-analysis
#11
Ionut Negoi, Sorin Hostiuc, Alexandru Runcanu, Ruxandra Irina Negoi, Mircea Beuran
BACKGROUND: The superior mesenteric artery (SMA) first approach was proposed recently as a new modification of the standard pancreaticoduodenectomy. Increasing evidence showed that a periadventiceal dissection of the SMA with early transection of the inflow during pancreaticoduodenectomy associates better early perioperative results, and setup the scene for long-term oncological benefits. The objectives of the current study are to compare the operative results and long-term oncological outcomes of SMA first approach pancreaticoduodenectomy (SMA-PD) with standard pancreaticoduodenectomy (S-PD)...
April 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28380966/flip-chip-integrated-silicon-mach-zehnder-modulator-with-a-28nm-fully-depleted-silicon-on-insulator-cmos-driver
#12
Zheng Yong, Stefan Shopov, Jared C Mikkelsen, Robert Mallard, Jason C C Mak, Sorin P Voinigescu, Joyce K S Poon
We present a silicon electro-optic transmitter consisting of a 28nm ultra-thin body and buried oxide fully depleted silicon-on-insulator (UTBB FD-SOI) CMOS driver flip-chip integrated onto a Mach-Zehnder modulator. The Mach-Zehnder silicon optical modulator was optimized to have a 3dB bandwidth of around 25 GHz at -1V bias and a 50 Ω impedance. The UTBB FD-SOI CMOS driver provided a large output voltage swing around 5 V<sub>pp</sub> to enable a high dynamic extinction ratio and a low device insertion loss...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28377566/initial-experience-with-aortic-valve-replacement-via-a-minimally-invasive-approach-a-comparison-of-stented-stentless-and-sutureless-valves
#13
Johanna Konertz, Konstantin Zhigalov, Alexander Weymann, Pascal M Dohmen
BACKGROUND This study aimed to compare the short-term outcomes of MIS-AVR among 3 different types of biological heart valves. MATERIAL AND METHODS Complete data were obtained from 79 patients who underwent MIS-AVR between January 2010 and June 2015. Patients were divided into 3 groups: 27 patients (group A) received Medtronic 3f® (Medtronic Inc., Fridley, MN, USA), 36 patients (group B) received DokimosPlus® (LabCor Laboratórios Ltda., Belo Horizonte, Brazil) and 16 patients (group C) received Perceval® (Sorin Biomedica Cardio S...
April 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28375157/isolated-polycystic-liver-disease-genes-define-effectors-of-polycystin-1-function
#14
Whitney Besse, Ke Dong, Jungmin Choi, Sohan Punia, Sorin V Fedeles, Murim Choi, Anna-Rachel Gallagher, Emily B Huang, Ashima Gulati, James Knight, Shrikant Mane, Esa Tahvanainen, Pia Tahvanainen, Simone Sanna-Cherchi, Richard P Lifton, Terry Watnick, York P Pei, Vicente E Torres, Stefan Somlo
Dominantly inherited isolated polycystic liver disease (PCLD) consists of liver cysts that are radiologically and pathologically identical to those seen in autosomal dominant polycystic kidney disease, but without clinically relevant kidney cysts. The causative genes are known for fewer than 40% of PCLD index cases. Here, we have used whole exome sequencing in a discovery cohort of 102 unrelated patients who were excluded for mutations in the 2 most common PCLD genes, PRKCSH and SEC63, to identify heterozygous loss-of-function mutations in 3 additional genes, ALG8, GANAB, and SEC61B...
April 4, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28372645/anesthesiologists-perceptions-of-minimum-acceptable-work-habits-of-nurse-anesthetists
#15
Ilana I Logvinov, Franklin Dexter, Bradley J Hindman, Sorin J Brull
STUDY OBJECTIVE: Work habits are non-technical skills that are an important part of job performance. Although non-technical skills are usually evaluated on a relative basis (i.e., "grading on a curve"), validity of evaluation on an absolute basis (i.e., "minimum passing score") needs to be determined. DESIGN: Survey and observational study. PATIENTS: None. INTERVENTIONS: None. MEASUREMENTS: The theme of "work habits" was assessed using a modification of Dannefer et al...
May 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28371906/lipid-modifying-effects-of-krill-oil-in-humans-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
Sorin Ursoniu, Amirhossein Sahebkar, Maria-Corina Serban, Diana Antal, Dimitri P Mikhailidis, Arrigo Cicero, Vasilios Athyros, Manfredi Rizzo, Jacek Rysz, Maciej Banach
Some experimental and clinical trials have shown that krill oil, extracted from small red crustaceans, might be an effective lipid-modifying agent, but the evidence is not conclusive. The effect of krill oil supplements on plasma lipid concentrations was assessed through a systematic review of the literature and a meta-analysis of available randomized controlled trials. PubMed and Scopus were searched up to March 25, 2016, to identify RCTs investigating the effect of krill oil supplements on plasma lipids. Randomized controlled trials that investigated the impact of at least 2 weeks of supplementation with krill oil on plasma/serum concentrations of at least one of the main lipid parameters (ie, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, or triglycerides) and that reported sufficient information on plasma/serum lipid levels at baseline and at the end of study in both krill oil and control groups were eligible for inclusion...
March 22, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28369148/right-atrial-volume-by-cardiovascular-magnetic-resonance-predicts-mortality-in-patients-with-heart-failure-with-reduced-ejection-fraction
#17
Alexander Ivanov, Ambreen Mohamed, Ahmed Asfour, Jean Ho, Saadat A Khan, Onn Chen, Igor Klem, Kumudha Ramasubbu, Sorin J Brener, John F Heitner
BACKGROUND: Right Atrial Volume Index (RAVI) measured by echocardiography is an independent predictor of morbidity in patients with heart failure (HF) with reduced ejection fraction (HFrEF). The aim of this study is to evaluate the predictive value of RAVI assessed by cardiac magnetic resonance (CMR) for all-cause mortality in patients with HFrEF and to assess its additive contribution to the validated Meta-Analysis Global Group in Chronic heart failure (MAGGIC) score. METHODS AND RESULTS: We identified 243 patients (mean age 60 ± 15; 33% women) with left ventricular ejection fraction (LVEF) ≤ 35% measured by CMR...
2017: PloS One
https://www.readbyqxmd.com/read/28350123/design-synthesis-and-pharmaco-toxicological-assessment-of-5-mercapto-1-2-4-triazole-derivatives-with-antibacterial-and-antiproliferative-activity
#18
Marius Mioc, Codruta Soica, Vasile Bercean, Sorin Avram, Mihaela Balan-Porcarasu, Dorina Coricovac, Roxana Ghiulai, Delia Muntean, Florina Andrica, Cristina Dehelean, Demetrios A Spandidos, Aristides M Tsatsakis, Ludovic Kurunczi
The extensive biochemical research of multiple types of cancer has revealed important enzymatic signaling pathways responsible for tumor occurrence and progression, thus compelling the need for the discovery of new means with which to block these signaling cascades. The phosphoinositide 3-kinase/ protein kinase B (PI3K/AKT) pathway, which plays an important role in maintaining relevant cellular functions, exhibits various alterations in common human cancers, thus representing a suitable target in cancer treatment...
March 14, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28349045/safety-profile-of-liver-fibroscan-in-patients-with-cardiac-pacemakers-or-implantable-cardioverter-defibrillators
#19
Yin Chan, Stephanie Pranke, Farid Rashidi, Shravan Nosib, Lawrence Worobetz
Background. Emerging evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery diseases and arrhythmias. The FibroScan (Echosens, France), a widely available, noninvasive device, is able to detect liver fibrosis and steatosis within this patient population. However, the FibroScan is currently contraindicated in patients with cardiac pacemakers (PM) or implantable cardioverter-defibrillators (ICD). Objective. To determine the safety profile of FibroScan testing in patients with PM or ICD...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28348394/the-g2a-receptor-gpr132-contributes-to-oxaliplatin-induced-mechanical-pain-hypersensitivity
#20
Stephan W Hohmann, Carlo Angioni, Sorin Tunaru, Seungkyu Lee, Clifford J Woolf, Stefan Offermanns, Gerd Geisslinger, Klaus Scholich, Marco Sisignano
Chemotherapy-induced peripheral neuropathic pain (CIPN) is a common and severe debilitating side effect of many widely used cytostatics. However, there is no approved pharmacological treatment for CIPN available. Among other substances, oxaliplatin causes CIPN in up to 80% of treated patients. Here, we report the involvement of the G-protein coupled receptor G2A (GPR132) in oxaliplatin-induced neuropathic pain in mice. We found that mice deficient in the G2A-receptor show decreased mechanical hypersensitivity after oxaliplatin treatment...
March 27, 2017: Scientific Reports
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