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Perivascular macrophage

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https://www.readbyqxmd.com/read/29030904/development-and-maintenance-of-the-brain-s-immune-toolkit-microglia-and-non-parenchymal-brain-macrophages
#1
REVIEW
Jose P Lopez-Atalaya, Katharine E Askew K, Amanda Sierra, Diego Gomez-Nicola
Microglia and non-parenchymal macrophages located in the perivascular space, the meninges and the choroid plexus are independent immune populations that play vital roles in brain development, homeostasis, and tissue healing. Resident macrophages account for a significant proportion of cells in the brain and their density remains stable throughout the lifespan thanks to constant turnover. Microglia develop from yolk sac progenitors, later evolving through intermediate progenitors in a fine-tuned process in which intrinsic factors and external stimuli combine to progressively sculpt their cell-type specific transcriptional profiles...
October 14, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29016715/matrix-metalloproteinase-2-knockout-prevents-angiotensin-ii-induced-vascular-injury
#2
Tlili Barhoumi, Julio C Fraulob-Aquino, Muhammad Oneeb Rehman Mian, Sofiane Ouerd, Noureddine Idris-Khodja, Ku-Geng Huo, Asia Rehman, Antoine Caillon, Bianca Dancose-Giambattisto, Talin Ebrahimian, Stéphanie Lehoux, Pierre Paradis, Ernesto L Schiffrin
Aims: Matrix metalloproteinases (MMPs) have been implicated in the development of hypertension in animal models and humans. Mmp2 deletion did not change Ang II-induced blood pressure (BP) rise. However, whether Mmp2 knockout affects angiotensin (Ang) II-induced vascular injury has not been tested. We sought to determine whether Mmp2 knockout will prevent Ang II-induced vascular injury. Methods and results: A fourteen-day Ang II infusion (1000 ng/kg/min, SC) increased systolic BP, decreased vasodilatory responses to acetylcholine, induced mesenteric artery (MA) hypertrophic remodelling, and enhanced MA stiffness in wild-type (WT) mice...
July 20, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28990052/macrophage-migration-inhibitory-factor-knockdown-inhibit-viability-and-induce-apoptosis-of-pvm-ms
#3
Wenjing Zhang, Jian Zheng, Juan Meng, Lingling Neng, Xiaohua Chen, Zhaobing Qin
Previous studies have suggested that macrophage migration inhibitory factor (MIF) serves an important role in hearing function; however, the underlying mechanism remains unclear. In the present study, perivascular‑resident macrophage‑like melanocytes (PVM/Ms) from the stria vascularis of the lateral cochlear wall in young and aged mice were isolated. The mRNA and protein expression levels of MIF were determined using reverse transcription‑quantitative polymerase chain reaction analysis, and western blotting, respectively...
October 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28987033/trem2-expression-in-the-human-brain-a-marker-of-monocyte-recruitment
#4
Marie Fahrenhold, Sonja Rakic, John Classey, Carol Brayne, Paul G Ince, James A R Nicoll, Delphine Boche
Mutation in the triggering receptor expressed on myeloid cells (TREM) 2 gene has been identified as a risk factor for several neurodegenerative diseases including Alzheimer's disease (AD). Experimental studies using animal models of AD have highlighted a number of functions associated with TREM2 and its expression by microglial cells. It has therefore been assumed that this is also the case in humans. However, there is very limited information concerning the cellular expression of TREM2 in the human brain. As part of investigations of microglia using post-mortem resources provided by the Medical Research Council Cognitive Function and Ageing Studies (MRC-CFAS), we immunostained the cerebral cortex of 299 participants for TREM2 using the Sigma antibody HPA010917 and compared with the macrophage/microglial markers Iba1 and CD68...
October 7, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28948650/vegf-as-a-modulator-of-the-innate-immune-response-in-glioblastoma
#5
Kati Turkowski, Susan Brandenburg, Annett Mueller, Irina Kremenetskaia, Alexander D Bungert, Anne Blank, Matthäus Felsenstein, Peter Vajkoczy
VEGF is an important factor in tumor vascularization and used as target for anti-angiogenic treatment strategies in glioma. In this study, we demonstrate for the first time that VEGF is a modulator of the innate immune response with suppressive effects on the immunologic and pro-angiogenic function of microglia/macrophages in a glioblastoma rodent model. High level of VEGF led to threefold enlarged tumor volumes and a pronounced remodeling of the vascular structure along with a reduced infiltration of microglia/macrophages by approximately 50%...
September 26, 2017: Glia
https://www.readbyqxmd.com/read/28942490/susceptibility-of-mice-to-bovine-herpesvirus-type-5-infection-in-the-central-nervous-system
#6
L P Mesquita, R C Costa, M M Fusuma, F R P Bruhn, E Mori, E M Pituco, C M C Mori, R Weiblen, P C Maiorka
Bovine herpesvirus type 5 (BoHV-5) is an important pathogen that causes meningoencephalitis in cattle. Few studies have used the mouse as a model for BoHV-5 infection. Despite the fact that BoHV-5 can infect mice with immune deficiencies, little is known about viral replication, immune response, and the course of infection in the central nervous system (CNS) of wild-type mice. Therefore, the aim of this study was to evaluate the response in the CNS of BALB/c mice acutely infected with BoHV-5 at different days post-inoculation (dpi)...
September 23, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28935667/upregulation-of-herv-k-is-linked-to-immunity-and-inflammation-in-pulmonary-arterial-hypertension
#7
Toshie Saito, Kazuya Miyagawa, Shih-Yu Chen, Rasa Tamosiuniene, Lingli Wang, Orr Sharp, Erik Samayoa, Daisuke Harada, Jan-Renier A J Moonen, Aiqin Cao, Pin-I Chen, Jan K Hennigs, Mingxia Gu, Caiyun G Li, Ryan D Leib, Dan Li, Christopher M Adams, Patricia A Del Rosario, Matthew A Bill, Francois Haddad, Jose G Montoya, William Robinson, Wendy J Fantl, Garry P Nolan, Roham T Zamanian, Mark R Nicolls, Charles Y Chiu, Maria E Ariza, Marlene Rabinovitch
Background -Immune dysregulation has been linked to occlusive vascular remodeling in pulmonary arterial hypertension (PAH) that is hereditary, idiopathic or associated with other conditions. Circulating autoantibodies, lung perivascular lymphoid tissue and elevated cytokines have been related to PAH pathogenesis but without clear understanding of how these abnormalities are initiated, perpetuated and connected in the progression of disease. We therefore set out to identify specific target antigens in PAH lung immune complexes as a starting point toward resolving these issues to better inform future application of immunomodulatory therapies...
September 21, 2017: Circulation
https://www.readbyqxmd.com/read/28905075/ouabain-attenuates-ovalbumin-induced-airway-inflammation
#8
José Guilherme F M Galvão, Luiz Henrique Agra Cavalcante-Silva, Deyse Cristina M Carvalho, Laércia Karla D P Ferreira, Talissa Mozzini Monteiro, Adriano Francisco Alves, Larissa Adilis M P Ferreira, Francisco Allysson A F Gadelha, Marcia Regina Piuvezam, Sandra Rodrigues-Mascarenhas
PURPOSE: Ouabain, an Na(+)/K(+)-ATPase inhibitor hormone, presents immunomodulatory actions, including anti-inflammatory effect on acute inflammation models. METHODS: In the present study, the effect of ouabain in a model of allergic airway inflammation induced by ovalbumin (OVA) was assessed. RESULTS: Initially, it was observed that ouabain treatment inhibited cellular migration induced by OVA on bronchoalveolar lavage fluid (BALF), mostly granulocytes, without modulating macrophage migration...
September 13, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28875290/evaluation-of-99m-tc-radiolabeled-macrophage-mannose-receptor-specific-nanobodies-for-targeting-of-atherosclerotic-lesions-in-mice
#9
Gezim Bala, Henri Baudhuin, Isabel Remory, Kris Gillis, Pieterjan Debie, Ahmet Krasniqi, Tony Lahoutte, Geert Raes, Nick Devoogdt, Bernard Cosyns, Sophie Hernot
PURPOSE: Macrophage accumulation characterizes the development of atherosclerotic plaques, and the presence of certain macrophage subsets might be an indicator of plaque phenotype and (in)stability. The macrophage mannose receptor (MMR) is expressed on alternatively activated macrophages and found at sites of intraplaque hemorrhage and neovascularization. It has been proposed as target to identify vulnerable plaques. Therefore, we aimed to assess the feasibility of using anti-MMR nanobodies (Nbs) as molecular tracers for nuclear imaging in an animal model of atherosclerosis...
September 5, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28858880/the-histopathology-of-urticaria-revisited-clinical-pathological-study
#10
Aviv Barzilai, Lior Sagi, Sharon Baum, Henri Trau, Michael Schvimer, Iris Barshack, Michal Solomon
BACKGROUND: The classic histopathological findings of urticaria include dermal edema and a sparse perivascular infiltrate of neutrophils, eosinophils, macrophages, and lymphocytes. However, this pattern is inconsistently described. OBJECTIVE: To describe the histological and immunofluorescence characteristics of urticaria and to identify distinctive patterns. METHODS: A retrospective study was performed in which the medical files and biopsy specimens of 58 patients with acute and chronic classical urticaria were reviewed...
October 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28855075/origin-and-production-of-inflammatory-perivascular-macrophages-in-pulmonary-hypertension
#11
REVIEW
Jonathan Florentin, Partha Dutta
Myeloid cells, including monocytes and macrophages participate in steady state immune homeostasis and help mount the adaptive immune response during infection. The function and production of these cells in sterile inflammation, such as pulmonary hypertension (PH), is understudied. Emerging data indicate that pulmonary inflammation mediated by lung perivascular macrophages is a key pathogenic driver of pulmonary remodeling leading to increased right ventricular systolic pressure (RVSP). However, the origin of these macrophages in pulmonary inflammation is unknown...
August 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28838996/the-selective-tie2-inhibitor-rebastinib-blocks-recruitment-and-function-of-tie2hi-macrophages-in-breast-cancer-and-pancreatic-neuroendocrine-tumors
#12
Allison S Harney, George S Karagiannis, Jeanine Pignatelli, Bryan D Smith, Ece Kadioglu, Scott C Wise, Molly M Hood, Michael D Kaufman, Cynthia B Leary, Wei-Ping Lu, Gada Al-Ani, Xiaoming Chen, David Entenberg, Maja H Oktay, Yarong Wang, Lawrence Chun, Michele De Palma, Joan G Jones, Daniel L Flynn, John S Condeelis
Tumor-infiltrating myeloid cells promote tumor progression by mediating angiogenesis, tumor cell intravasation and metastasis, which can offset the effects of chemotherapy, radiation, and anti-angiogenic therapy. Here, we show that the kinase switch control inhibitor rebastinib inhibits Tie2, a tyrosine kinase receptor expressed on endothelial cells and pro-tumoral Tie2-expressing macrophages in mouse models of metastatic cancer. Rebastinib reduces tumor growth and metastasis in an orthotopic mouse model of metastatic mammary carcinoma through reduction of Tie2+ myeloid cell infiltration, anti-angiogenic effects, and blockade of tumor cell intravasation mediated by perivascular Tie2Hi/Vegf-AHi macrophages in the tumor microenvironment of metastasis (TMEM)...
August 24, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28838042/the-role-of-infiltrating-immune-cells-in-dysfunctional-adipose-tissue
#13
Tomasz J Guzik, Dominik S Skiba, Rhian M Touyz, David G Harrison
Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a hallmark of non-communicable diseases. It is characterized by chronic low-grade inflammation and is observed in obesity, metabolic disorders such as insulin resistance and diabetes. While classically it has been identified by increased cytokine or chemokine expression, such as increased MCP-1, RANTES, IL-6, interferon (IFN) gamma or TNFα, mechanistically, immune cell infiltration is a prominent feature of the dysfunctional AT...
July 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28836308/siglec-h-is-a-microglia-specific-marker-that-discriminates-microglia-from-cns-associated-macrophages-and-cns-infiltrating-monocytes
#14
Hiroyuki Konishi, Masaaki Kobayashi, Taikan Kunisawa, Kenta Imai, Akira Sayo, Bernard Malissen, Paul R Crocker, Katsuaki Sato, Hiroshi Kiyama
Several types of myeloid cell are resident in the CNS. In the steady state, microglia are present in the CNS parenchyma, whereas macrophages reside in boundary regions of the CNS, such as perivascular spaces, the meninges and choroid plexus. In addition, monocytes infiltrate into the CNS parenchyma from circulation upon blood-brain barrier breakdown after CNS injury and inflammation. Although several markers, such as CD11b and ionized calcium-binding adapter molecule 1 (Iba1), are frequently used as microglial markers, they are also expressed by other types of myeloid cell and microglia-specific markers were not defined until recently...
August 24, 2017: Glia
https://www.readbyqxmd.com/read/28782084/brain-perivascular-macrophages-characterization-and-functional-roles-in-health-and-disease
#15
REVIEW
Giuseppe Faraco, Laibaik Park, Josef Anrather, Costantino Iadecola
Perivascular macrophages (PVM) are a distinct population of resident brain macrophages characterized by a close association with the cerebral vasculature. PVM migrate from the yolk sac into the brain early in development and, like microglia, are likely to be a self-renewing cell population that, in the normal state, is not replenished by circulating monocytes. Increasing evidence implicates PVM in several disease processes, ranging from brain infections and immune activation to regulation of the hypothalamic-adrenal axis and neurovascular-neurocognitive dysfunction in the setting of hypertension, Alzheimer disease pathology, or obesity...
August 7, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28760942/perivascular-adipose-tissue-angiotensin-ii-type-1-receptor-promotes-vascular-inflammation-and-aneurysm-formation
#16
Tomoki Sakaue, Jun Suzuki, Mika Hamaguchi, Chika Suehiro, Akiko Tanino, Tomoaki Nagao, Teruyoshi Uetani, Jun Aono, Hirotomo Nakaoka, Mie Kurata, Tomohisa Sakaue, Takafumi Okura, Takumi Yasugi, Hironori Izutani, Jitsuo Higaki, Shuntaro Ikeda
Perivascular adipose tissue exhibits characteristics of active local inflammation, which contributes to the development of atherosclerotic disease as a complication of obesity/metabolic syndrome. However, the precise role of perivascular adipose tissue in the progression of abdominal aortic aneurysm remains unclear. To test the hypothesis that genetic deletion of angiotensin II type 1a (AT1a) receptor in perivascular visceral adipose tissue (VAT) can attenuate aortic aneurysm formation in apolipoprotein E-deficient (ApoE(-/-)) mice, we performed adipose tissue transplantation experiments by using an angiotensin II-induced aneurysm murine model, in which we transplanted VAT from ApoE(-/-) or ApoE(-/-) AT1a(-/-) donor mice onto the abdominal aorta of ApoE(-/-) recipient mice...
October 2017: Hypertension
https://www.readbyqxmd.com/read/28752628/intranasal-delivery-of-dexamethasone-efficiently-controls-lps-induced-murine-neuroinflammation
#17
G Meneses, G Gevorkian, A Florentino, M A Bautista, A Espinosa, G Acero, G Díaz, A Fleury, I N Pérez Osorio, A Del Rey, G Fragoso, E Sciutto, H Besedovsky
Neuroinflammation is the hallmark of several infectious and neurodegenerative diseases. Synthetic glucocorticoids (GCs) are the first-line immunosuppressive drugs used for controlling neuroinflammation. A delayed diffusion of GCs molecules and the high systemic doses required for brain-specific targeting lead to severe undesirable effects, particularly when lifelong treatment is required. Therefore, there is an urgent need for improving this current therapeutic approach. The intranasal (i.n.) route is being employed increasingly for drug delivery to the brain via the olfactory system...
July 28, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28710904/m1-macrophage-induced-endothelial-to-mesenchymal-transition-promotes-infantile-hemangioma-regression
#18
Keith Q Wu, Christopher S Muratore, Eui-Young So, Changqi Sun, Patrycja M Dubielecka, Anthony M Reginato, Olin D Liang
Infantile hemangiomas are benign tumors of vascular endothelial cells (ECs), characterized by three distinct stages: proliferating phase, involuting phase, and involuted phase. The mechanisms that trigger involution of hemangioma into fibro-fatty tissue remain unknown. We report a novel mechanism by which M1-polarized macrophages induce endothelial-to-mesenchymal transition (EndMT) and promote hemangioma regression. M1- but not M2-polarized macrophages induced EndMT in ECs. Tumor necrosis factor-α and, to a lesser extent, IL-1β and interferon-γ were the most potent cytokines produced by the M1 macrophages that induce in vitro EndMT...
September 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28702933/characterization-of-simbu-serogroup-virus-infections-in-type-i-interferon-receptor-knock-out-mice
#19
Kerstin Tauscher, Kerstin Wernike, Melina Fischer, Anne Wegelt, Bernd Hoffmann, Jens Peter Teifke, Martin Beer
In late 2011, Schmallenberg virus (SBV), a novel, arthropod-borne, teratogenic orthobunyavirus, emerged near the German/Dutch border and thereafter spread rapidly throughout the continent thereby causing great economic losses in European livestock. SBV mainly infects ruminants and closely related viruses such as Sabo virus (SABOV), Simbu virus (SIMBUV) and Sathuperi virus (SATV) have been isolated from their insect-vectors or putative ruminant hosts. However, information about their pathogenesis and in vivo studies with SABOV, SIMBUV, and SATV are scarce...
July 12, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28683667/early-immunomodulatory-effects-of-implanted-human-perivascular-stromal-cells-during-bone-formation
#20
Carolyn A Meyers, Jiajia Xu, Lei Zhang, Greg Asatrian, Catherine Ding, Noah Yan, Kristen Broderick, Justin Sacks, Raghav Goyal, Xinli Zhang, Kang Ting, Bruno Péault, Chia Soo, Aaron W James
Human perivascular stem/stromal cells (PSC) are a multipotent mesodermal progenitor cell population defined by their perivascular residence. PSC are most commonly derived from subcutaneous adipose tissue, and recent studies have demonstrated the high potential for clinical translation of this fluorescence activated cell sorting (FACS) derived cell population for bone tissue engineering. Specifically, purified PSC induce greater bone formation than unpurified stroma taken from the same patient sample. Here, we examined the differences in early innate immune response to human PSC or unpurified stroma (stromal vascular fraction, SVF) during the in vivo process of bone formation...
July 6, 2017: Tissue Engineering. Part A
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