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Cx3CR1 NFAT

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https://www.readbyqxmd.com/read/17623099/genome-wide-transcriptional-analysis-of-resting-and-il2-activated-human-natural-killer-cells-gene-expression-signatures-indicative-of-novel-molecular-signaling-pathways
#1
Karen Dybkaer, Javeed Iqbal, Guimei Zhou, Huimin Geng, Li Xiao, Alexander Schmitz, Francesco d'Amore, Wing C Chan
BACKGROUND: Human natural killer (NK) cells are the key contributors of innate immune response and the effector functions of these cells are enhanced by cytokines such as interleukine 2 (IL2). We utilized genome-wide transcriptional profiling to identify gene expression signatures and pathways in resting and IL2 activated NK cell isolated from peripheral blood of healthy donors. RESULTS: Gene expression profiling of resting NK cells showed high expression of a number of cytotoxic factors, cytokines, chemokines and inhibitory and activating surface NK receptors...
2007: BMC Genomics
https://www.readbyqxmd.com/read/15347678/interleukin-il-15-and-il-2-reciprocally-regulate-expression-of-the-chemokine-receptor-cx3cr1-through-selective-nfat1-and-nfat2-dependent-mechanisms
#2
Jana Barlic, David H McDermott, Maya N Merrell, Jacqueline Gonzales, Laura E Via, Philip M Murphy
We have recently reported that interleukin (IL)-15 and IL-2, which signal through IL-2Rbetagamma, oppositely regulate expression of the proinflammatory chemokine receptor CX3CR1. Here we delineate molecular mechanisms responsible for this paradox. By using a luciferase reporter plasmid, we identified a 433-bp region spanning the major transcriptional start point of human CX3CR1 that, when expressed in human peripheral blood mononuclear cells (PBMCs), possessed strong constitutive promoter activity. IL-2 and IL-15 treatment increased and abolished this activity, respectively, mimicking their effects on endogenous CX3CR1...
November 19, 2004: Journal of Biological Chemistry
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