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https://www.readbyqxmd.com/read/29161788/aggressive-supratentorial-ependymoma-rela-fusion-positive-with-extracranial-metastasis-a-case-report
#1
Seong-Ik Kim, Yoojin Lee, Seung Ki Kim, Hyoung Jin Kang, Sung-Hye Park
Ependymoma is the third most common pediatric primary brain tumor. Ependymomas are categorized according to their locations and genetic abnormalities, and these two parameters are important prognostic factors for patient outcome. For supratentorial (ST) ependymomas, RELA fusion-positive ependymomas show a more aggressive behavior than YAP1 fusion-positive ependymomas. Extracranial metastases of intra-axial neuroepithelial tumors are extremely rare. In this paper, we report a case of aggressive anaplastic ependymoma arising in the right frontoparietal lobe, which had genetically 1q25 gain, CDKN2A homozygous deletion, and L1CAM overexpression...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29160382/lung-cancer-changes-in-histology-gender-and-age-over-the-last-30-years-in-brazil
#2
Maria Teresa Ruiz Tsukazan, Álvaro Vigo, Vinícius Duval da Silva, Carlos Henrique Barrios, Jayme de Oliveira Rios, José Antônio de Figueiredo Pinto
OBJECTIVE: To describe the trends in tumor histology, gender and age among patients with non-small cell lung cancer (NSCLC) treated with lung resection. The histology of lung cancer has changed in developed countries, and there is still little information available on the topic for developing countries. METHODS: This was a retrospective study of 1,030 patients with NSCLC treated with lung resection between 1986 and 2015 at a university hospital in southern Brazil...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29159782/cecal-bascule-a-systematic-review-of-the-literature
#3
REVIEW
B E Lung, S B Yelika, A S Murthy, M Gachabayov, P Denoya
BACKGROUND: Cecal volvulus is a rare clinical entity with an average incidence of 2.8-7.1 per million people per year, accounting for 1-2% of all large bowel obstructions. Cecal bascule is the rarest type of cecal volvulus, accounting for 5-20% of all cases. Although several case reports have been published, there is no consensus regarding its diagnosis and treatment. The aim of this study was to review the literature on cecal bascule in order to summarize the etiopathogenesis, clinical features, diagnosis, and treatment options...
November 20, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29158124/improved-survival-with-increased-time-to-radiation-and-sequential-chemotherapy-after-surgery-for-pn2-non-small-cell-lung-cancer
#4
Karna Sura, Inga S Grills, Charles C Vu, Craig W Stevens, Hong Ye, Thomas M Guerrero
BACKGROUND: Currently, the ideal timing for postoperative radiotherapy (PORT) and chemotherapy is unknown. The present study evaluated their relative timing on overall survival (OS) using the National Cancer Database (NCDB). MATERIALS AND METHODS: The NCDB was queried for patients from 2004 to 2012 with resected non-small-cell lung cancer (NSCLC), pathologically involved N2 (pN2) nodes, and negative margins. All patients underwent adjuvant chemotherapy and external beam radiotherapy...
November 17, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29157203/survival-time-following-resection-of-intracranial-metastases-from-nsclc-development-and-validation-of-a-novel-nomogram
#5
Xiaoyu Ji, Yingjie Zhuang, Xiangye Yin, Qiong Zhan, Xinli Zhou, Xiaohua Liang
BACKGROUND: Brain metastases (BM) from non-small cell lung cancer (NSCLC) are the most frequent intracranial tumors. To identify patients who might benefit from intracranial surgery, we compared the six existing prognostic indexes(PIs) and built a nomogram to predict the survival for NSCLC with BM before they intended to receive total intracranial resection in China. METHODS: First, clinical data of NSCLC presenting with BM were retrospectively reviewed. All of the patients had received total intracranial resection and were randomly distributed to developing cohort and validation cohort by 2:1...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29157115/subgroup-analysis-based-on-prognostic-and-predictive-gene-signatures-for-adjuvant-chemotherapy-in-early-stage-non-small-cell-lung-cancer-patients
#6
Hojin Moon, Yuan Zhao, Dustin Pluta, Hongshik Ahn
In treating patients diagnosed with early Stage I non-small-cell lung cancer (NSCLC), doctors must choose surgery alone, Adjuvant Cisplatin-Based Chemotherapy (ACT) alone or both. For patients with resected stages IB to IIIA, clinical trials have shown a survival advantage from 4-15% with the adoption of ACT. However, due to the inherent toxicity of chemotherapy, it is necessary for doctors to identify patients whose chance of success with ACT is sufficient to justify the risks. This research seeks to use gene expression profiling in the development of a statistical decision-making algorithm to identify patients whose survival rates will improve from ACT treatment...
November 20, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/29156778/worse-disease-free-tumor-specific-and-overall-survival-in-surgically-resected-lung-adenocarcinoma-patients-with-alk-rearrangement
#7
Qiongqiong Gao, Pupu Li, Xiangli Jiang, Zhongli Zhan, Qingna Yan, Bo Zhang, Chun Huang
Introduction: This study determined the prevalence of anaplastic lymphoma kinase (ALK) rearrangement, and identified the associations of ALK rearrangement with clinicopathologic characteristics and treatment outcomes in patients with surgically-resected stage I-III lung adenocarcinoma. Methods: A total of 534 surgically-resected lung adenocarcinoma patients were studied. The prevalence of ALK protein over-expression was determined by a fully-automated immunochemistry assay (with mouse monoclonal Ventana D5F3 antibody), and the associations of ALK rearrangement with clinicopathologic characteristics and treatment outcomes were analyzed...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156450/current-indications-and-outcome-of-pulmonary-resections-of-tuberculosis-complications-in-ibadan-nigeria
#8
Mudasiru A Salami, Arinola A Sanusi, Victor O Adegboye
OBJECTIVES: To review the current indications and outcome of pulmonary resections for tuberculosis (TB) at the Cardiothoracic Surgery unit of the University College Hospital, Ibadan, Nigeria. SUBJECTS AND METHODS: A retrospective case series of patients who had lung resections from January 2014 to January 2017 was performed. Data obtained from medical records included demographics, presenting symptoms, indication for surgery, preoperative evaluation and preparation, operative procedure, post-operative complications and follow up...
November 16, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29156014/exhaustive-preoperative-staging-increases-survival-in-resected-adrenal-oligometastatic-non-small-cell-lung-cancer-a-multicentre-study
#9
Julien De Wolf, Jocelyn Bellier, Francoise Lepimpec-Barthes, Francois Tronc, Christophe Peillon, Alain Bernard, Jean-Philippe Le Rochais, Olivier Tiffet, Edouard Sage, Alain Chapelier, Henri Porte
OBJECTIVES: Adrenal oligometastatic non-small-cell lung cancer is rare, and surgical management remains controversial. METHODS: We performed a multicentre, retrospective study from January 2004 to December 2014. The main objective was to evaluate survival in patients who had undergone adrenalectomy after resection of primary lung cancer. Secondary objectives were to determine prognostic, survival and recurrence factors. RESULTS: Fifty-nine patients were included...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29155612/health-reform-and-utilization-of-high-volume-hospitals-for-complex-cancer-operations
#10
Andrew P Loehrer, David C Chang, Zirui Song, George J Chang
PURPOSE: Underinsured patients are less likely to receive complex cancer operations at hospitals with high surgical volumes (high-volume hospitals, or HVHs), which contributes to disparities in care. To date, the impact of insurance coverage expansion on site of complex cancer surgery remains unknown. METHODS: Using the 2006 Massachusetts coverage expansion as a natural experiment, we searched the Hospital Cost and Utilization Project state inpatient databases for Massachusetts and control states (New York, New Jersey, and Florida) between 2001 and 2011 to evaluate changes in the utilization of HVHs for resections of bladder, esophageal, stomach, pancreatic, rectal, or lung cancer after the expansion of insurance coverage...
November 20, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29153966/nomogram-to-predict-cause-specific-mortality-in-patients-with-surgically-resected-stage-i-non-small-cell-lung-cancer-a-competing-risk-analysis
#11
Huaqiang Zhou, Yaxiong Zhang, Zeting Qiu, Gang Chen, Shaodong Hong, Xi Chen, Zhonghan Zhang, Yan Huang, Li Zhang
BACKGROUND: The objective of this study was to evaluate the probability of cause-specific death and other causes of death in patients with stage I non-small-cell lung cancer (NSCLC) who underwent surgery. We also built competing risk nomograms to predict the prognosis of patients with NSCLC. PATIENTS AND METHODS: Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We identified patients who underwent surgery with stage I NSCLC between 2004 and 2013...
October 28, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29153898/the-significance-of-the-pd-l1-expression-in-non-small-cell-lung-cancer-trenchant-double-swords-as-predictive-and-prognostic-markers
#12
REVIEW
Kazuki Takada, Gouji Toyokawa, Fumihiro Shoji, Tatsuro Okamoto, Yoshihiko Maehara
Lung cancer is the leading cause of death due to cancer worldwide. Surgery, chemotherapy, and radiotherapy have been the standard treatment for lung cancer, and targeted molecular therapy has greatly improved the clinical course of patients with non-small-cell lung cancer (NSCLC) harboring driver mutations, such as in epidermal growth factor receptor and anaplastic lymphoma kinase genes. Despite advances in such therapies, the prognosis of patients with NSCLC without driver oncogene mutations remains poor. Immunotherapy targeting programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) has recently been shown to improve the survival in advanced NSCLC...
October 28, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29153417/the-efficacy-of-transbronchial-needle-aspiration-with-endobronchial-ultrasonography-using-a-guide-sheath-for-peripheral-pulmonary-lesions-suspected-to-be-lung-cancer
#13
Ken Arimura, Yasuo Sekine, Kenzo Hiroshima, Akitoshi Sato, Mizue Hasegawa, Hideki Katsura, Etsuko Tagaya, Mitsuko Kondo, Jun Tamaoki
BACKGROUND: The efficacy of transbronchial needle aspiration (TBNA) with endobronchial ultrasonography using a guide sheath (EBUS-GS) for cases of peripheral pulmonary lesions (PPLs) has not been well established. The purpose of this study was to evaluate the efficacy of TBNA with EBUS-GS for PPLs. METHODS: We evaluated 130 patients suspected to have lung cancer who underwent transbronchial brushing (brushing), transbronchial biopsy (TBB), and TBNA with EBUS-GS...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29152497/molecular-analysis-driven-video-assisted-thoracic-surgery-resections-in-bilateral-synchronous-lung-cancers-from-the-test-tube-to-the-operatory-room
#14
REVIEW
Sergio Nicola Forti Parri, Barbara Bonfanti, Alessandra Cancellieri, Dario De Biase, Rocco Trisolini, Stefania Zoboli, Luca Bertolaccini, Piergiorgio Solli, Giovanni Tallini
Synchronous cancers are not such rare clinical conditions. Nevertheless, even after the 8th edition of the TNM classification of the lung cancer, the surgical approach for patients presenting with synchronous bilateral lung cancer is still under debate. The resection of both lesions in the case of synchronous bilateral lung cancer is reasonable, but, on the other hand, is the lobectomy the correct choice in the event of the single primary with a contralateral metastatic lesion? In this case report, we describe how the molecular analysis and the detection of the EGFR, KRAS and TP53 mutations in both tumours have determined in a patient the two tumours as primary and both the right surgical approach...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29151535/multiple-endotracheal-metastases-of-lung-cancer-after-bronchoscopic-intervention-a-case-report
#15
Kazuki Hayasaka, Satoshi Shiono, Naoki Yanagawa
A 65-year-old man presented with obstructive pneumonia due to squamous cell carcinoma of the lung, which invaded the right main bronchus. Argon plasma coagulation was performed, which reduced his symptoms. Right pneumonectomy was performed after preoperative chemotherapy; the pathological diagnosis was T3N1M0 Stage IIIA. Fifteen months after surgery, he presented with bloody sputum. Bronchoscopy showed multiple endotracheal tumors, and a pathological examination revealed squamous cell carcinoma; the same histology as the primary lung cancer...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29150179/-therapeutic-strategies-in-patients-undergoing-surgery-for-non-small-cell-lung-cancer-results-of-the-escap-2011-cphg-study-promoted-by-the-french-college-of-general-hospital-respiratory-physicians-cphg
#16
F Pinquié, F Goupil, J-P Oster, A Dixmier, P-A Renault, A Lévy, J-P Mathieu, N Paillot, F C Goutorbe, P Masson, O Molinier, D Debieuvre, M Grivaux
BACKGROUND: The aim of ESCAP-2011-CPHG, promoted by the French College of General Hospital Respiratory Physicians, was to describe therapeutic strategies in lung cancer in the first 2 years after diagnosis, in a real-life setting. This article focuses on patients undergoing surgical management of a non-small cell lung cancer (NSCLC). METHODS: A prospective multicentre study was conducted in 53 French general hospitals. For each patient with lung cancer diagnosed in 2010, a standardised form was completed following each change in treatment strategy up to 2 years after diagnosis...
November 14, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29150043/synchronous-esophageal-and-lung-cancer
#17
REVIEW
Amar N Mukerji, Andrea Wolf
Synchronous lung and esophageal cancers are rare but represent a unique challenge to thoracic surgeons. The literature is limited but series describe long-term survival with curative surgery for concomitant esophageal and lung cancer. Preoperative risk assessment is critical because surgical resection of both cancers requires adequate cardiopulmonary function and performance status. Chemotherapy and radiation are used as adjuvant therapy or as primary treatment of unresectable lesions. Although long-term survival for patients with concomitant lung and esophageal cancer is lower than that of patients with either one alone, survival with curative surgery is higher than that of patients with metastatic disease of either primary...
February 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29150041/thoracic-surgery-in-early-stage-small-cell-lung-cancer
#18
REVIEW
Matthew Low, Sharon Ben-Or
Small cell lung cancer (SCLC) has a complex history and remains difficult to treat. Most patients with SCLC present with metastases or extensive stage disease, rendering most not amenable to surgical resection. Until recently, chemoradiotherapy had become the standard of care for all patients with SCLC. However, recent studies have shown improved survival following surgical resection with chemotherapy in patients with early-stage SCLC, specifically those with stage I disease. This article presents the literature on treatment of early-stage SCLC and addresses the question of whether surgery should be considered a viable treatment modality...
February 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29150031/thoracic-surgery-in-the-pregnant-patient
#19
REVIEW
Brian Whang
Thoracic surgeons are sometimes asked to consult on the management of a patient who is pregnant. Conditions commonly encountered are empyema, spontaneous pneumothorax, and diaphragmatic hernia. Lung cancer is rarely seen in pregnancy, but its incidence is rising. Diagnostic imaging and perioperative management involve the navigation of fetal risks and nuances in maternal physiology. Shared decision making within a multidisciplinary framework will optimally guide the course of management.
February 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29149260/an-aorto-oesophageal-fistula-caused-by-a-fish-bone-resulting-in-an-accidental-discovery-of-an-invasive-adenocarcinoma-in-the-lung
#20
Bao Long Zhang, Ji Ning Sun, Na Na Liu, Fu Zhi Cao
An aorto-oesophageal fistula is a rare, life-threatening complication caused by sharp foreign bodies in the oesophagus. We report an aorto-oesophageal fistula in the inferior segment of thoracic oesophagus caused by a fish bone. Multiplanar reconstruction of computed tomography and computed tomography angiography demonstrated that a foreign body had pierced from the left posterior wall of the oesophagus into the descending aortic wall. These computed tomography images can help radiologists make the correct diagnosis and provide precise evidence for clinicians to perform a timely surgical intervention...
November 15, 2017: Interactive Cardiovascular and Thoracic Surgery
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