keyword
MENU ▼
Read by QxMD icon Read
search

LRRK2 NFAT

keyword
https://www.readbyqxmd.com/read/29545945/the-kinase-lrrk2-is-differently-expressed-in-chronic-rhinosinusitis-with-and-without-nasal-polyps
#1
Yue Ma, Chunquan Zheng, Le Shi
Background: Chronic rhinosinusitis (CRS), commonly divided into CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) is an inflammatory disease which mechanism remain unclear. Leucine-rich repeat kinase 2 (LRRK2) has been proved to be a negative regulator of inflammation response while its role in pathogenesis of CRS has yet to be revealed. This research study was designed to investigate the relationship between the expression level and biologic role of LRRK2 in CRS. Methods: Expression of LRRK2 mRNA and noncoding repressor of NFAT (NRON) were examined by qRT-PCR...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29472933/leucine-rich-repeat-kinase-2-controls-the-ca-2-nuclear-factor-of-activated-t-cells-il-2-pathway-during-aspergillus-non-canonical-autophagy-in-dendritic-cells
#2
Alicia Yoke Wei Wong, Vasilis Oikonomou, Giuseppe Paolicelli, Antonella De Luca, Marilena Pariano, Jan Fric, Hock Soon Tay, Paola Ricciardi-Castagnoli, Teresa Zelante
The Parkinson's disease-associated protein, Leucine-rich repeat kinase 2 (LRRK2), a known negative regulator of nuclear factor of activated T cells (NFAT), is expressed in myeloid cells such as macrophages and dendritic cells (DCs) and is involved in the host immune response against pathogens. Since, the Ca2+ /NFAT/IL-2 axis has been previously found to regulate DC response to the fungus Aspergillus , we have investigated the role played by the kinase LRRK2 during fungal infection. Mechanistically, we found that in the early stages of the non-canonical autophagic response of DCs to the germinated spores of Aspergillus , LRRK2 undergoes progressive degradation and regulates NFAT translocation from the cytoplasm to the nucleus...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/22390486/lrrk2-as-a-negative-regulator-of-nfat-implications-for-the-pathogenesis-of-inflammatory-bowel-disease
#3
COMMENT
Puja Vora, Dermot P B McGovern
Inflammatory bowel disease encompasses two chronic, complex relapsing diseases believed to be caused by an excessive and poorly controlled immune response to the intestinal microbiota. The advent of genome-wide association scans has allowed for rapid identification of multiple susceptibility genes for Crohn's disease and ulcerative colitis. A locus containing LRRK2 and MUC19 is a confirmed Crohn's disease susceptibility locus. This genetic association precipitates an important functional study in which Liu et al...
March 2012: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/22012435/don-t-move-lrrk2-arrests-nfat-in-the-cytoplasm
#4
COMMENT
Bana Jabri, Luis B Barreiro
No abstract text is available yet for this article.
October 19, 2011: Nature Immunology
https://www.readbyqxmd.com/read/21983832/the-kinase-lrrk2-is-a-regulator-of-the-transcription-factor-nfat-that-modulates-the-severity-of-inflammatory-bowel-disease
#5
Zhihua Liu, Jinwoo Lee, Scott Krummey, Wei Lu, Huaibin Cai, Michael J Lenardo
Leucine-rich repeat kinase 2 (LRRK2) has been identified by genome-wide association studies as being encoded by a major susceptibility gene for Crohn's disease. Here we found that LRRK2 deficiency conferred enhanced susceptibility to experimental colitis in mice. Mechanistic studies showed that LRRK2 was a potent negative regulator of the transcription factor NFAT and was a component of a complex that included the large noncoding RNA NRON (an NFAT repressor). Furthermore, the risk-associated allele encoding LRRK2 Met2397 identified by a genome-wide association study for Crohn's disease resulted in less LRRK2 protein post-translationally...
October 9, 2011: Nature Immunology
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"