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https://www.readbyqxmd.com/read/28537990/impact-of-the-primary-information-source-used-for-decision-making-on-treatment-perceptions-and-regret-in-prostate-cancer
#1
Narek Shaverdian, Amar U Kishan, Darlene Veruttipong, D Jeffrey Demanes, Patrick Kupelian, Susan McCloskey, Michael L Steinberg, Christopher R King
OBJECTIVE: To assess the impact of the primary source of information used by prostate cancer patients to select a radiation treatment on their overall treatment experience and on treatment regret. METHODS: Patients with low to favorable intermediate-risk prostate cancer treated with stereotactic body radiation therapy, intensity-modulated radiation therapy, or high-dose rate brachytherapy were surveyed. The questionnaire explored the decision-making experience, treatment experience, and treatment regret...
May 23, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28469191/integrated-single-and-two-photon-light-sheet-microscopy-using-accelerating-beams
#2
Peeter Piksarv, Dominik Marti, Tuan Le, Angelika Unterhuber, Lindsey H Forbes, Melissa R Andrews, Andreas Stingl, Wolfgang Drexler, Peter E Andersen, Kishan Dholakia
We demonstrate the first light sheet microscope using propagation invariant, accelerating Airy beams that operates both in single- and two-photon modes. The use of the Airy beam permits us to develop an ultra compact, high resolution light sheet system without beam scanning. In two-photon mode, an increase in the field of view over the use of a standard Gaussian beam by a factor of six is demonstrated. This implementation for light sheet microscopy opens up new possibilities across a wide range of biomedical applications, especially for the study of neuronal processes...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28452616/an-ovine-model-of-cerebral-catheter-venography-for-implantation-of-an-endovascular-neural-interface
#3
Thomas James Oxley, Nicholas Lachlan Opie, Gil Simon Rind, Kishan Liyanage, Sam Emmanuel John, Stephen Ronayne, Alan James McDonald, Anthony Dornom, Timothy John Haynes Lovell, Peter John Mitchell, Iwan Bennett, Sebastien Bauquier, Leon Norris Warne, Chris Steward, David Bruce Grayden, Patricia Desmond, Stephen M Davis, Terence John O'Brien, Clive N May
OBJECTIVE Neural interface technology may enable the development of novel therapies to treat neurological conditions, including motor prostheses for spinal cord injury. Intracranial neural interfaces currently require a craniotomy to achieve implantation and may result in chronic tissue inflammation. Novel approaches are required that achieve less invasive implantation methods while maintaining high spatial resolution. An endovascular stent electrode array avoids direct brain trauma and is able to record electrocorticography in local cortical tissue from within the venous vasculature...
April 28, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28444412/biochemical-and-genetic-analyses-of-n-metabolism-in-maize-testcross-seedlings-1-leaves
#4
Ignacio Trucillo Silva, Hari Kishan R Abbaraju, Lynne P Fallis, Hongjun Liu, Michael Lee, Kanwarpal S Dhugga
Aside from the identification of 32 QTL for N metabolism in the seedling leaves of a maize testcross population, alanine aminotransferase was found to be a central enzyme in N assimilation. Excessive application of nitrogen (N) fertilizer to grow commercial crops like maize is a cause of concern because of the runoff of excess N into streams and rivers. Breeding maize with improved N use efficiency (NUE) would reduce environmental pollution as well as input costs for the farmers. An understanding of the genetics underlying N metabolism is key to breeding for NUE...
April 25, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28437498/superior-mesenteric-artery-syndrome-as-a-complication-of-scoliosis-surgery
#5
Philip K Louie, Bryce A Basques, Adam Bitterman, Shalin Shah, Kishan Patel, Isaac Abramchayev, Jonathan Lewin
Superior mesenteric artery (SMA) syndrome is a rare and potentially life-threatening complication of scoliosis surgery. The anatomical relationship of the duodenum and the superior mesenteric artery, the correction of angular deformity of the spine, and the normal adolescent growth spurt all contribute to the condition. We report the case of a 14-year-old boy who had a history of idiopathic scoliosis and presented with bilious vomiting that had persisted for 7 days after posterior T9-L4 fusion with instrumentation...
March 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28410235/cysteinyl-leukotriene-receptor-1-facilitates-tumorigenesis-in-a-mouse-model-of-colitis-associated-colon-cancer
#6
Janina Osman, Sayeh Savari, Naveen Kumar Chandrashekar, Kishan Bellamkonda, Desiree Douglas, Anita Sjölander
Cysteinyl leukotriene receptor 1 (CysLT1R) has been shown to be up-regulated in the adenocarcinomas of colorectal cancer patients, which is associated with a poor prognosis. In a spontaneous model of colon cancer, CysLT1R disruption was associated with a reduced tumor burden in double-mutant female mice (ApcMin/+/Cysltr1-/-) compared to ApcMin/+ littermates. In the current study, we utilized a genetic approach to investigate the effect of CysLT1R in the induced azoxymethane/dextran sulfate sodium (AOM/DSS) model of colitis-associated colon cancer...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409644/amphiphilic-tobramycin-lysine-conjugates-sensitize-multidrug-resistant-gram-negative-bacteria-to-rifampicin-and-minocycline
#7
Yinfeng Lyu, Xuan Yang, Sudeep Goswami, Bala Kishan Gorityala, Temilolu Idowu, Ronald Domalaon, George G Zhanel, Anshan Shan, Frank Schweizer
Chromosomally encoded low membrane permeability and highly efficient efflux systems are major mechanisms by which Pseudomonas aeruginosa evades antibiotic actions. Our previous reports have shown that amphiphilic tobramycin-fluoroquinolone hybrids can enhance efficacy of fluoroquinolone antibiotics against multidrug-resistant (MDR) P. aeruginosa isolates. Herein, we report on a novel class of tobramycin-lysine conjugates containing an optimized amphiphilic tobramycin-C12 tether that sensitize Gram-negative bacteria to legacy antibiotics...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28399907/what-do-register-based-studies-tell-us-about-migrant-mental-health-a-scoping-review
#8
Kishan Patel, Anne Kouvonen, Ciara Close, Ari Väänänen, Dermot O'Reilly, Michael Donnelly
BACKGROUND: Previous studies investigating the mental health of migrants have shown mixed results. The increased availability of register data has led to a growing number of register-based studies in this research area. This is the first scoping review on the use of registry and record-linkage data to examine the mental health of migrant populations. The aim of this scoping review is to investigate the topics covered and to assess the results yielded from these studies. METHODS: We used a scoping review methodology to search MedLine, PubMed, PsychINFO, Web of Science, and SCOPUS for all register-based studies on the mental health of migrants...
April 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28399372/a-tobramycin-vector-enhances-synergy-and-efficacy-of-efflux-pump-inhibitors-against-multidrug-resistant-gram-negative-bacteria
#9
Xuan Yang, Sudeep Goswami, Bala Kishan Gorityala, Ronald Domalaon, Yinfeng Lyu, Ayush Kumar, George G Zhanel, Frank Schweizer
Drug efflux mechanisms interact synergistically with the outer membrane permeability barrier of Gram-negative bacteria, leading to intrinsic resistance that presents a major challenge for antibiotic drug development. Efflux pump inhibitors (EPIs) which block the efflux of antibiotics synergize antibiotics, but the clinical development of EPI/antibiotic combination therapy to treat multidrug-resistant (MDR) Gram-negative infections has been challenging. This is in part caused by the inefficiency of current EPIs to penetrate the outer membrane and resist efflux...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28392959/restricted-blood-flow-exercise-in-sedentary-overweight-african-american-females-may-increase-muscle-strength-and-decrease-endothelial-function-and-vascular-autoregulation
#10
Vernon Bond, Bryan Heath Curry, Krishna Kumar, Sudhakar Pemminati, Vasavi Rakesh Gorantla, Kishan Kadur, Richard Mark Millis
OBJECTIVES: Exercise with partially restricted blood flow is a low-load, low-intensity resistance training regimen which may have the potential to increase muscle strength in the obese, elderly and frail who are unable to do high-load training. Restricted blood flow exercise has also been shown to affect blood vessel function variably and can, therefore, contribute to blood vessel dysfunction. This pilot study tests the hypothesis that unilateral resistance training of the leg extensors with partially restricted blood flow increases muscle strength and decreases vascular autoregulation...
March 2017: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28379390/arid5a-deficient-mice-are-highly-resistant-to-bleomycin-induced-lung-injury
#11
Praveen Kumar Dubey, Kazuya Masuda, Kishan Kumar Nyati, Mohammad Mahabub -Uz Zaman, Jaya Prakash Chalise, David Millrine, Wang Kai, Barry Ripley, Tadamitsu Kishimoto
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are among the major causes of death worldwide due to acute inflammation in the lung. AT-rich interactive domain-containing 5a (Arid5a) is an RNA-binding protein involved in inflammatory autoimmune disease through post-transcriptional control of Il6, Stat3 and Tbx21 gene expression. We found that Arid5a-deficient mice were highly refractory to bleomycin (BLM)-induced lethality. Arid5a deficiency suppressed lung pathology, cytokine production (especially, IL-6), and clinical symptoms in BLM-treated mice...
February 1, 2017: International Immunology
https://www.readbyqxmd.com/read/28373255/associations-of-moderate-to-vigorous-intensity-physical-activity-and-body-mass-index-with-glycated-haemoglobin-within-the-general-population-a-cross-sectional-analysis-of-the-2008-health-survey-for-england
#12
Kishan Bakrania, Thomas Yates, Charlotte L Edwardson, Danielle H Bodicoat, Dale W Esliger, Jason M R Gill, Aadil Kazi, Latha Velayudhan, Alan J Sinclair, Naveed Sattar, Stuart J H Biddle, Mark Hamer, Melanie J Davies, Kamlesh Khunti
OBJECTIVES: To investigate the associations of objectively measured moderate-to-vigorous-intensity physical activity (MVPA) and body mass index (BMI) with glycated haemoglobin (HbA1c) in a national sample of English adults. METHODS: The 2008 Health Survey for England data were used with 1109 participants aged ≥18 providing complete data. MVPA time was assessed using an accelerometer. Weighted linear regression models, adjusted for several confounders, quantified the associations between continuous measures of MVPA and BMI with HbA1c...
April 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28360227/increased-arterial-stiffness-is-an-independent-predictor-of-renal-function-decline-in-patients-with-type-2-diabetes-mellitus-younger-than-60%C3%A2-years
#13
Nikolaos Fountoulakis, Chiraag Thakrar, Kishan Patel, Giancarlo Viberti, Luigi Gnudi, Janaka Karalliedde
BACKGROUND: The objective of this study was to evaluate whether aortic pulse wave velocity (Ao-PWV) predicts estimated glomerular filtration rate (eGFR) decline in patients with type 2 diabetes mellitus. METHODS AND RESULTS: This prospective single-center cohort study investigated 211 type 2 diabetes mellitus patients with eGFR ≥45 mL/min with a baseline mean age of 60.1 years (range, 30-82 years). The mean±SD baseline eGFR was 85±26.1 mL/min. We divided the cohort into 2 groups above (n=117, "older") and below (n=94, "younger") the mean age to evaluate whether Ao-PWV predicted progression of kidney disease differentially in older and younger patients...
March 30, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28359513/exercise-training-in-patients-with-chronic-heart-failure-and-atrial-fibrillation
#14
Nancy Luo, Peter Merrill, Kishan S Parikh, David J Whellan, Ileana L Piña, Mona Fiuzat, William E Kraus, Dalane W Kitzman, Steven J Keteyian, Christopher M O'Connor, Robert J Mentz
BACKGROUND: The safety and efficacy of aerobic exercise in heart failure (HF) patients with atrial fibrillation (AF) has not been well evaluated. OBJECTIVES: This study examined whether outcomes with exercise training in HF vary according to AF status. METHODS: HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) randomized 2,331 ambulatory HF patients with ejection fraction ≤35% to exercise training or usual care...
April 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28330124/somaclonal-variations-and-their-applications-in-horticultural-crops-improvement
#15
REVIEW
Hare Krishna, Mahdi Alizadeh, Dhurendra Singh, Udayvir Singh, Nitesh Chauhan, Maliheh Eftekhari, Radha Kishan Sadh
The advancements made in tissue culture techniques has made it possible to regenerate various horticultural species in vitro as micropropagation protocols for commercial scale multiplication are available for a wide range of crops. Clonal propagation and preservation of elite genotypes, selected for their superior characteristics, require high degree of genetic uniformity amongst the regenerated plants. However, plant tissue culture may generate genetic variability, i.e., somaclonal variations as a result of gene mutation or changes in epigenetic marks...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28301348/discord-among-radiation-oncologists-and-urologists-in-the-postoperative-management-of-high-risk-prostate-cancer
#16
Amar U Kishan, Gillian Duchesne, Pin-Chieh Wang, Jean-Claude M Rwigema, Arun U Kishan, Christopher Saigal, Matthew Rettig, Michael L Steinberg, Christopher R King
OBJECTIVE: To query specialty-specific differences regarding postoperative radiotherapy (RT) for high-risk prostate cancer. MATERIALS AND METHODS: Electronic mail survey of radiation oncologists (ROs) and urologists. We sought to maximize absolute response number to capture contemporary practice ethos. The outcome of interest was association between response and specialty. Training level/expertise, practice setting, percentage of consultation caseload consisting of high-risk prostate cancer, and nationality were set as effect modifiers for multivariate logistic regression...
March 15, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28290712/development-of-olmesartan-medoxomil-lipid-based-nanoparticles-and-nanosuspension-preparation-characterization-and-comparative-pharmacokinetic-evaluation
#17
Arun B, Narendar D, Kishan Veerabrahma
The aim was to enhance the oral bioavailability of olmesartan medoxomil (OM) by preparing solid lipid nanoparticles (SLNs) and comparing with nanosuspension (OM-NS). OM-SLNs and OM-NS were prepared by known methods. Prepared SLNs were evaluated for physical characters and in vivo pharmacokinetic (PK) performance in rats. OM-NS showed more than four-fold increase in the solubility. During DSC and XRD studies, drug incorporated in SLNs was found to be in amorphous form. The relative bioavailability of OM-SLN and OM-NS was 7...
March 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28276891/removal-of-h2s-pollutant-from-gasifier-syngas-by-a-multistage-dual-flow-sieve-plate-column-wet-scrubber
#18
Swamy Kurella, Pawan Kishan Bhukya, B C Meikap
The objective of this study was to observe the performance of a lab-scale three-stage dual-flow sieve plate column scrubber for hydrogen sulfide (H2S) gas removal from a gas stream, in which the H2S concentration was similar to that of gasifier syngas. The tap water was used as scrubbing liquid. The gas and liquid were operated at flow rates in the range of 16.59 × 10(-4)-27.65 × 10(-4) Nm(3)/s and 20.649 × 10(-6)-48.183 × 10(-6) m(3)/s, respectively. The effects of gas and liquid flow rates on the percentage removal of H2S were studied at 50-300 ppm inlet concentrations of H2S...
May 12, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28273084/vitamin-d-deficiency-predicts-infections-in-young-north-indian-children-a-secondary-data-analysis
#19
Ranadip Chowdhury, Sunita Taneja, Nita Bhandari, Bireshwar Sinha, Ravi Prakash Upadhyay, Maharaj Kishan Bhan, Tor A Strand
BACKGROUND: Recent studies have demonstrated a relationship between poor vitamin D status and respiratory infections and diarrhea among young children. Acute lower respiratory infections (ALRI) and diarrhea are among the two most important causes of death in under-5 children. In this paper, we examined the extent to which vitamin-D deficiency (<10 ng/ml) predicts ALRI, clinical pneumonia and diarrhea among 6 to 30 months old children. METHODS: We used data from a randomized controlled trial (RCT) of daily folic acid and/or vitamin B12 supplementation for six months in 6 to 30 months old children conducted in Delhi, India...
2017: PloS One
https://www.readbyqxmd.com/read/28271908/development-of-olmesartan-medoxomil-optimized-nanosuspension-using-the-box-behnken-design-to-improve-oral-bioavailability
#20
K Nagaraj, D Narendar, V Kishan
The aim of the present investigation was to enhance the oral bioavailability of olmesartan medoxomil by improving its solubility and dissolution rate by preparing nanosuspension (OM-NS), using the Box-Behnken design. In this, four factors were evaluated at three levels. Independent variables include: concentration of drug (X1), concentration of surfactant (X2), concentration of polymer (X3) and number of homogenization cycles (X4). Based on preliminary studies, the size (Y1), zeta potential (ZP) (Y2) and % drug release at 5 min (Y3) were chosen as dependent responses...
July 2017: Drug Development and Industrial Pharmacy
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