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K C Dharam Kumar, Yadalla Hari Kishan Kumar, Vivekananda Neladimmanahally
Background: Androgenetic alopecia (AGA) is the most common cause of hair loss. Although it is a medically benign condition, it can have a significant psychosocial impact on patients. "Metabolic syndrome" (MetS) is a collection of clinical signs that focus on cardiovascular and diabetes-related parameters. Despite the high burden of AGA and MetS in India, specific data on the participants are relatively sparse. Aim of the Study: The aim of is to study the association of AGA with MetS and its parameters...
March 2018: Indian Journal of Endocrinology and Metabolism
Kanok Boriboonsomsin, Thomas Durbin, George Scora, Kent Johnson, Daniel Sandez, Alexander Vu, Yu Jiang, Andrew Burnette, Seungju Yoon, John Collins, Zhen Dai, Carl Fulper, Sandeep Kishan, Michael Sabisch, Doug Jackson
Real-world vehicle and engine activity data were collected from 90 heavy-duty vehicles in California, United States, most of which have engine model year 2010 or newer and are equipped with selective catalytic reduction (SCR). The 90 vehicles represent 19 different groups defined by a combination of vocational use and geographic region. The data were collected using advanced data loggers that recorded vehicle speed, position (latitude and longitude), and more than 170 engine and aftertreatment parameters (including engine load and exhaust temperature) at the frequency of one Hz...
June 2018: Data in Brief
John V Hegde, Minsong Cao, Victoria Y Yu, Amar U Kishan, Narek Shaverdian, James Lamb, Michael L Steinberg
The accurate delivery of stereotactic body radiotherapy (SBRT) for definitive prostate cancer treatment is aided by intrafraction image guidance. The common methods for intrafraction imaging require the invasive placement of fiducial markers or electromagnetic transponders. Recently, a magnetic resonance imaging (MRI)-guided tri-cobalt-60 head radiotherapy system has become available for treatment, which can utilize real-time cine MRI to non-invasively track prostate motion. We report on a clinical vignette using this technique to deliver SBRT for the definitive treatment of intermediate-risk prostate cancer...
April 6, 2018: Curēus
Mohd Adnan, Eyad Alshammari, Syed Amir Ashraf, Kartik Patel, Kishan Lad, Mitesh Patel
Currently, there is an absolute concern for all nations in agricultural productivity to meet growing demands of human population. In recent time, biosurfactants produced by diverse group of microorganisms are used to achieve such demands as it is known for its ecofriendly use in elimination of plant pathogens and for increasing the bioavailability of nutrients for plants. Endophytic fungi are the important source of secondary metabolites and novel bioactive compounds for different biological applications. In the present study, endophytic fungi Xylaria regalis (X...
2018: BioMed Research International
Krishnan B Binsila, Sellappan Selvaraju, Subrata Kumar Ghosh, Sivashanmugam Parthipan, Santhanahalli Siddalingappa Archana, Arunachalam Arangasamy, Jai Kishan Prasad, Raghavendra Bhatta, Janivara Parameshwaraiah Ravindra
The present study aimed to isolate and enrich putative SSCs from ram testes, which are positive for promyelocytic leukaemia zinc-finger protein (PLZF). The putative SSCs were isolated using a combination of enzymes with different concentrations, collagenase (1 and 2 mg/ml), hyaluronidase (1 mg/ml) and trypsin (0.25 and 0.5 mg/ml). The isolated SSCs were purified using an extracellular matrix such as laminin (20 μg/ml), DSA-lectin (5 μg/ml) and gelatin (0.2%) in combination with BSA (0.5 mg/ml)...
April 18, 2018: Animal Reproduction Science
Amar U Kishan, Marguerite Tyran, Michael L Steinberg, Stuart B Holden, Minsong Cao
Nearly 30% of patients treated with radical prostatectomy for prostate cancer ultimately develop biochemical recurrences, and nearly a quarter of men with nonpalpable biochemical recurrences have gross local recurrences identified with magnetic resonance imaging (MRI). The only curative intervention for patients with recurrent disease after radical prostatectomy is salvage radiotherapy - this is particularly true for patients with gross local recurrences. Furthermore, even in patients with an incurable metastatic disease, a local recurrence can be the source of significant morbidity and should be addressed...
March 22, 2018: Curēus
Brandon L Brown, Tony Asante, Haley R Welch, Morgan M Sandelski, Sarah M Drejet, Kishan Shah, Elizabeth M Runge, Taha Z Shipchandler, Kathryn J Jones, Chandler L Walker
Importance: Functional and anatomical outcomes after surgical repair of facial nerve injury may be improved with the addition of polyethylene glycol (PEG) to direct suture neurorrhaphy. The application of PEG has shown promise in treating spinal nerve injuries, but its efficacy has not been evaluated in treatment of cranial nerve injuries. Objective: To determine whether PEG in addition to neurorrhaphy can improve functional outcomes and synkinesis after facial nerve injury...
May 17, 2018: JAMA Facial Plastic Surgery
Masayoshi Ohkuro, Jun-Dal Kim, Yoshikazu Kuboi, Yuki Hayashi, Hayase Mizukami, Hiroko Kobayashi-Kuramochi, Kenzo Muramoto, Manabu Shirato, Fumiko Michikawa-Tanaka, Jun Moriya, Teruya Kozaki, Kazuma Takase, Kenichi Chiba, Kishan Lal Agarwala, Takayuki Kimura, Makoto Kotake, Tetsuya Kawahara, Naoki Yoneda, Shinsuke Hirota, Hiroshi Azuma, Nobuko Ozasa-Komura, Yoshiaki Ohashi, Masafumi Muratani, Keiji Kimura, Ieharu Hishinuma, Akiyoshi Fukamizu
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a chronic intestinal inflammatory condition initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Calreticulin (CRT), a calcium-binding chaperone, is known as a partner in the activation of integrin α subunits (ITGAs). The relationship between their interaction and the pathogenesis of IBD is largely unknown. Here we show that a small molecule, orally active ER-464195-01, inhibits the CRT binding to ITGAs, which suppresses the adhesiveness of both T cells and neutrophils...
May 17, 2018: Nature Communications
Peter Haslehurst, Zhengyi Yang, Kishan Dholakia, Nigel Emptage
Light sheet fluorescence microscopy offers considerable potential to the cellular neuroscience community as it makes it possible to image extensive areas of neuronal structures, such as axons or dendrites, with a low light budget, thereby minimizing phototoxicity. However, the shallow depth of a light sheet, which is critical for achieving high contrast, well resolved images, adds a significant challenge if fast functional imaging is also required, as multiple images need to be collected across several image planes...
May 1, 2018: Biomedical Optics Express
David C Scofield, Jeffrey D Rytlewski, Paul Childress, Kishan Shah, Aamir Tucker, Faisal Khan, Jessica Peveler, Ding Li, Todd O McKinley, Tien-Min G Chu, Debra L Hickman, Melissa A Kacena
This study was initiated as a component of a larger undertaking designed to study bone healing in microgravity aboard the International Space Station (ISS). Spaceflight experimentation introduces multiple challenges not seen in ground studies, especially with regard to physical space, limited resources, and inability to easily reproduce results. Together, these can lead to diminished statistical power and increased risk of failure. It is because of the limited space, and need for improved statistical power by increasing sample size over historical numbers, NASA studies involving mice require housing mice at densities higher than recommended in the Guide for the Care and Use of Laboratory Animals (National Research Council, 2011)...
May 2018: Life Sciences in Space Research
Saurabh Sharma, Samrat Mazumdar, Kishan S Italiya, Tushar Date, Ram I Mahato, Anupama Mittal, Deepak Chitkara
miR-34a is a master tumor suppressor playing a key role in the several signalling mechanisms involved in cancer. However its delivery to the cancer cells is the bottleneck in its clinical translation. Herein we report cationic amphiphilic copolymers grafted with cholesterol (chol), N,N-dimethyldipropylenetriamine (cation chain) and 4-(2-aminoethyl)morpholine (morph) for miR-34a delivery. The copolymer interacts with miR-34a at low N/P ratios (~2/1) to form nanoplexes of size ~108 nm and a zeta potential ~ +39 mV...
May 10, 2018: Molecular Pharmaceutics
Jonathan Nylk, Kaley McCluskey, Miguel A Preciado, Michael Mazilu, Zhengyi Yang, Frank J Gunn-Moore, Sanya Aggarwal, Javier A Tello, David E K Ferrier, Kishan Dholakia
Scattering and absorption limit the penetration of optical fields into tissue. We demonstrate a new approach for increased depth penetration in light-sheet microscopy: attenuation-compensation of the light field. This tailors an exponential intensity increase along the illuminating propagation-invariant field, enabling the redistribution of intensity strategically within a sample to maximize signal and minimize irradiation. A key attribute of this method is that only minimal knowledge of the specimen transmission properties is required...
April 2018: Science Advances
Tisson V Job, Girish T Narayana, Kishan K Venkappa, K Binu Nathan, Shameem Ahsan, Jayakkodi Harikaran
Aim: The aim of this study was to compare the remineralization potential of three different dentifrices using Raman spectroscopy and confocal laser scanning microscopy (CLSM). Materials and methods: Totally, 30 extracted intact impacted third molar teeth were selected and the crown of each tooth in a group was separated from the root and longitudinally sectioned into four parts with each section under a subgroup, of which one section was an untreated section, the second and the third sections were demineralized in a demineralizing solution, and the third section was remineralized after demineralization...
April 1, 2018: Journal of Contemporary Dental Practice
Aakash Singh, H L Kishan Prasad, K Jayaprakash Shetty, Nigi Ross Philip, Ruhi Salma, Anitha Chakravarthy
An urachal cyst is a sinus remaining from the allantois during embryogenesis which is rarely manifested in adults. The urachus is an embryologic remnant which degenerates after the birth. Defective obliteration of the urachus leads to urachal abnormalities. Urachal cyst is a rare pathology in adult women, and this pathology should be considered in the differential diagnosis of acute abdomen. Xanthogranulomatous cystitis (XC) is a benign disease of unknown etiology. The clinical manifestations of these are nonspecific such as lower abdominal pain, umbilical discharge with occasional hematuria...
April 2018: Urology Annals
Rachit K Saxena, Kishan Patel, C V Sameer Kumar, Kuldeep Tyagi, K B Saxena, Rajeev K Varshney
We report molecular mapping and inheritance of restoration of fertility (Rf) in A4 hybrid system in pigeonpea. We have also developed PCR-based markers amenable to low-cost genotyping to identify fertility restorer lines. Commercial hybrids in pigeonpea are based on A4 cytoplasmic male sterility (CMS) system, and their fertility restoration is one of the key prerequisites for breeding. In this context, an effort has been made to understand the genetics and identify quantitative trait loci (QTL) associated with restoration of fertility (Rf)...
April 28, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Carina Tudor-Sfetea, Riham Rabee, Muhammad Najim, Nima Amin, Mehak Chadha, Minal Jain, Kishan Karia, Varun Kothari, Tejus Patel, Melanie Suseeharan, Maroof Ahmed, Yusuf Sherwani, Sarim Siddiqui, Yuting Lin, Andreas B Eisingerich
BACKGROUND: Mobile health (mHealth) apps can offer users numerous benefits, representing a feasible and acceptable means of administering health interventions such as cognitive behavioral therapy (CBT). CBT is commonly used in the treatment of mental health conditions, where it has a strong evidence base, suggesting that it represents an effective method to elicit health behavior change. More importantly, CBT has proved to be effective in smoking cessation, in the context of smoking-related costs to the National Health Service (NHS) having been estimated to be as high as £2...
April 18, 2018: JMIR MHealth and UHealth
Jamey K Bower, Dushyant Barpaga, Sebastian Prodinger, Rajamani Krishna, H Todd Schaef, B Peter McGrail, Miroslaw A Derewinski, Radha Kishan Motkuri
Alkali-exchanged SSZ-13 adsorbents were investigated for their applicability in separating N2 from CO2 in flue gas streams using a dynamic breakthrough method. In contrast to IAST calculations based on equilibrium isotherms, K+ exchanged SSZ-13 was found to yield the best N2 productivity, comparable to Ni-MOF-74, under dynamic conditions where diffusion properties play a significant role. This was attributed to the selective, partial blockage of access to the chabazite cavities, enhancing the separation potential in a 15/85 CO2 /N2 binary gas mixture...
May 2, 2018: ACS Applied Materials & Interfaces
Kanok Boriboonsomsin, Thomas Durbin, George Scora, Kent Johnson, Daniel Sandez, Alexander Vu, Yu Jiang, Andrew Burnette, Seungju Yoon, John Collins, Zhen Dai, Carl Fulper, Sandeep Kishan, Michael Sabisch, Doug Jackson
On-road heavy-duty diesel vehicles are a major contributor of oxides of nitrogen (NOx ) emissions. In the US, many heavy-duty diesel vehicles employ selective catalytic reduction (SCR) technology to meet the 2010 emission standard for NOx . Typically, SCR needs to be at least 200°C before a significant level of NOx reduction is achieved. However, this SCR temperature requirement may not be met under some real-world operating conditions, such as during cold starts, long idling, or low speed/low engine load driving activities...
September 1, 2018: Science of the Total Environment
Anju Gangadharan, Themba Nyirenda, Kishan Patel, Nydia Jaimes-Delgadillo, Dominique Coletta, Takemi Tanaka, Ayal C Walland, Zena Jameel, Srinivasa Vedantam, Sittinon Tang, Ciaran Mannion, Grace Y Lee, Andre Goy, Andrew Pecora, K Stephen Suh
OBJECTIVES: Breast cancer (BC) is the second leading cause of cancer-related mortality in women. Bioinformatic analysis and expression screening showed that Prolactin Induced Protein (PIP) was differentially expressed in BC. The objective of this investigation was to characterize the expression pattern of PIP, an aspartyl proteinase, in malignant and non-malignant breast tissues. MATERIALS AND METHODS: Real time quantitative PCR was employed to analyze PIP and androgen receptor (AR) mRNA levels in BC cell lines and 190 normal tissues and tumor samples...
June 2018: Breast: Official Journal of the European Society of Mastology
Nidhi Pravinchandra Solanki, Kishan Karkala Venkappa, Nimisha Chinmay Shah
Introduction: This systematic review intended to compare the biocompatibility and sealing ability of mineral trioxide aggregate (MTA) and biodentine as root-end filling material. Materials and Methods: A computerized literature search was performed on March 1, 2016, in MEDLINE, PubMed, and COCHRANE LIBRARY for data published from January 2011 to March 2016. Quality assessment of the selected studies was performed according to the PRISMA guidelines, 2009. Results: A total of 12 in vitro studies were included in this review...
January 2018: Journal of Conservative Dentistry: JCD
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