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https://www.readbyqxmd.com/read/29450742/focused-cardiac-ultrasound-as-a-predictor-of-readmission-in-acute-decompensated-heart-failure
#1
Luke J Laffin, Amit V Patel, Narayan Saha, Julian Barbat, James K Hall, Matthew Cain, Kishan Parikh, Jay Shah, Kirk T Spencer
Acute decompensated heart failure (ADHF) is a common reason for admission to the hospital, and readmission is frequent. Multiple factors contribute to rehospitalizations, but inadequate assessment of volume status leading to persistent congestion is an important factor. We sought to determine if focused cardiac ultrasound (FCU) of the inferior vena cava (IVC), as a surrogate of volume status, would predict readmission of ADHF patients after index hospitalization. Patients admitted with a primary diagnosis of ADHF were prospectively enrolled...
February 15, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29447890/outcomes-of-adenoidectomy-alone-in-patients-less-than-3-years-old
#2
Kishan M Thadikonda, Amber D Shaffer, Amanda L Stapleton
OBJECTIVES: 1. Determine the percentage of patients under the age of 3 undergoing adenoidectomy-alone who require subsequent management of residual sleep disordered breathing (SDB).2. Characterize complications following adenoidectomy and determine if any perioperative factors are associated with intra-operative or post-operative complications and outcomes. METHODS: Case series with chart review was conducted including children seen at a tertiary care children's hospital between 2008 and 2012...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29436393/therapeutically-targeting-tumor-microenvironment-mediated-drug-resistance-in-estrogen-receptor-positive-breast-cancer
#3
Kevin Shee, Wei Yang, John W Hinds, Riley A Hampsch, Frederick S Varn, Nicole A Traphagen, Kishan Patel, Chao Cheng, Nicole P Jenkins, Arminja N Kettenbach, Eugene Demidenko, Philip Owens, Anthony C Faber, Todd R Golub, Ravid Straussman, Todd W Miller
Drug resistance to approved systemic therapies in estrogen receptor-positive (ER+) breast cancer remains common. We hypothesized that factors present in the human tumor microenvironment (TME) drive drug resistance. Screening of a library of recombinant secreted microenvironmental proteins revealed fibroblast growth factor 2 (FGF2) as a potent mediator of resistance to anti-estrogens, mTORC1 inhibition, and phosphatidylinositol 3-kinase inhibition in ER+ breast cancer. Phosphoproteomic analyses identified ERK1/2 as a major output of FGF2 signaling via FGF receptors (FGFRs), with consequent up-regulation of Cyclin D1 and down-regulation of Bim as mediators of drug resistance...
February 7, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29429921/comparison-of-lung-tumor-motion-measured-using-a-model-based-4dct-technique-and-a-commercial-protocol
#4
Dylan O'Connell, Narek Shaverdian, Amar U Kishan, David H Thomas, Tai H Dou, John H Lewis, James M Lamb, Minsong Cao, Stephen Tenn, Lee P Percy, Daniel A Low
PURPOSE: To compare lung tumor motion measured with a model-based technique to commercial 4-dimensional computed tomography (4DCT) scans and describe a workflow for using model-based 4DCT as a clinical simulation protocol. METHODS AND MATERIALS: Twenty patients were imaged using a model-based technique and commercial 4DCT. Tumor motion was measured on each commercial 4DCT dataset and was calculated on model-based datasets for 3 breathing amplitude percentile intervals: 5th to 85th, 5th to 95th, and 0th to 100th...
November 11, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29423177/immunization-practices-in-low-birth-weight-infants-from-rural-haryana-india-findings-from-secondary-data-analysis
#5
Ravi Prakash Upadhyay, Ranadip Chowdhury, Sarmila Mazumder, Sunita Taneja, Bireshwar Sinha, Jose Martines, Rajiv Bahl, Nita Bhandari, Maharaj Kishan Bhan
Background: Low birth weight (LBW) infants constitute a vulnerable subset of infants with impaired immunity in early life. In India, there is scarcity of studies that focus on immunization practices in such infants. This analysis aimed to examine immunization practices in LBW infants with the intention to identify areas requiring intervention. Methods: Data on immunization status of LBW infants enrolled in an individually randomized, double-masked, placebo-controlled trial of neonatal vitamin A supplementation were analysed...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29421005/systematic-review-and-meta-analysis-of-endovascular-and-surgical-revascularization-for-patients-with-chronic-lower-extremity-venous-insufficiency-and-varicose-veins
#6
Sreekanth Vemulapalli, Kishan Parikh, Remy Coeytaux, Victor Hasselblad, Amanda McBroom, Abigail Johnston, Giselle Raitz, Matthew J Crowley, Kathryn R Lallinger, W Schuyler Jones, Gillian D Sanders
BACKGROUND: Chronic lower extremity venous disease (LECVD) is twice as prevalent as coronary heart disease, and invasive therapies to treat LECVD accounted for an estimated $290 million in Medicare expenditures in 2015. Despite increasing use of these invasive therapies, their comparative effectiveness is unknown. METHODS: We conducted a systematic review and meta-analysis of treatments for patients (symptomatic and asymptomatic) with lower extremity varicosities and/or lower extremity chronic venous insufficiency/incompetence/reflux...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29414150/hypo-fractionated-stereotactic-radiotherapy-of-five-fractions-with-linear-accelerator-for-vestibular-schwannomas-a-systematic-review-and-meta-analysis
#7
REVIEW
Thien Nguyen, Courtney Duong, John P Sheppard, Seung Jin Lee, Amar U Kishan, Percy Lee, Stephen Tenn, Robert Chin, Tania B Kaprealian, Isaac Yang
Vestibular schwannomas (VS) are benign tumors stemming from the eighth cranial nerve. Treatment options for VS include conservative management, microsurgery, stereotactic radiosurgery, and fractionated radiotherapy. Though microsurgery has been the standard of care for larger lesions, hypo-fractionated stereotactic radiotherapy (hypo-FSRT) is an emerging modality. However, its clinical efficacy and safety have yet to be established. We conducted a systematic review and meta-analysis of manuscripts indexed in PubMed, Scopus, Web of Science, Embase, and Cochrane databases reporting outcomes of VS cases treated with hypo-FSRT...
January 12, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29413369/cardiac-rehabilitation-after-ventricular%C3%A2-assist-device-implantation-a-worthwhile-exercise
#8
EDITORIAL
Chetan B Patel, Kishan S Parikh
No abstract text is available yet for this article.
February 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29409866/introduction-of-sacrificial-bonds-to-hydrogels-to-increase-defect-tolerance-during-suturing-of-multilayer-vascular-grafts
#9
Allison Post, Alysha P Kishan, Patricia Diaz-Rodriguez, Egemen Tuzun, Mariah Hahn, Elizabeth Cosgriff-Hernandez
Small-caliber vascular grafts used in coronary artery bypass procedures typically fail due to the development of intimal hyperplasia or thrombosis. Our laboratory has developed a multilayered vascular graft with an electrospun polyurethane outer layer with improved compliance matching and a hydrogel inner layer that is both thromboresistant and promotes endothelialization. Initial in vivo studies showed that hydrogel particulates were dislodged from the hydrogel layer of the grafts during suturing. To address this problem, we developed and characterized a new hydrogel formulation that resists damage during suturing...
January 31, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29393637/size-selective-detection-of-picric-acid-by-fluorescent-palladium-macrocycles
#10
Sushil Kumar, Ram Kishan, Pramod Kumar, Sanya Pachisia, Rajeev Gupta
This work presents the synthesis and characterization of two palladium-based fluorescent macrocycles offering hydrogen-bonding cavities of contrasting dimensions. Both palladium macrocycles function as chemosensors for the detection of nitroaromatics, whereas the larger macrocycle not only illustrates nanomolar detection of picric acid but also transports its significant amount from an aqueous to an organic phase.
February 2, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29382140/the-effects-of-digital-marketing-of-unhealthy-commodities-on-young-people-a-systematic-review
#11
REVIEW
Limin Buchanan, Bridget Kelly, Heather Yeatman, Kishan Kariippanon
The marketing of unhealthy commodities through traditional media is known to impact consumers' product attitudes and behaviors. Less is known about the impacts of digital marketing (online promotional activities), especially among young people who have a strong online presence. This review systematically assesses the relationship between digital marketing and young people's attitudes and behaviors towards unhealthy commodities. Literature was identified in June 2017 by searches in six electronic databases. Primary studies (both qualitative and quantitative) that examined the effect of digital marketing of unhealthy food or beverages, alcohol and tobacco products on young people's (12 to 30 years) attitudes, intended and actual consumption were reviewed...
January 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29367375/delayed-presentation-of-a-virilising-pure-testosterone-secreting-adrenocortical-carcinoma-with-coexistent-composite-myelolipoma-and-a-venous-thrombus-extending-to-the-heart
#12
Rakesh M Sharma, Sanjay Sinha, Hari B Kishan, Michelle De Padua
A 40-year-old normotensive woman presented with abnormal facial hair for 4 years and amenorrhoea for 13 years. Hormonal, biochemical and haematological evaluation showed isolated elevation of serum testosterone and free testosterone. Her follicle-stimulating hormone and luteinising hormone were in the premenopausal range. Until recently she had reconciled to early 'menopause' and visited beauty clinics but never sought medical evaluation. Imaging revealed an enhancing left adrenal mass with fat densities and venous thrombus extending through the inferior vena cava to a 7 cm mass in the right atrium...
January 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29348283/unusual-feathery-cause-of-a-parapharyngeal-abscess-in-an-infant
#13
Wai Sum Cho, Mihaela Nistor, Kishan Ubayasiri, Mark Johnston
A 7-month-old boy presented to the emergency department with reduced oral intake, neck swelling and fever. Clinical examination revealed a 3 cm left parotid and left level I neck swelling with left medialised tonsil but no trismus. Computed imaging confirmed the presence of an abscess in the peritonsillar area with extension into the parapharyngeal space and deep lobe of the parotid gland. The abscess was incised and drained transorally. Following drainage of the abscess, a small 3 mm suspicious foreign body was seen...
January 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29341492/development-of-a-bi-modal-in-situ-crosslinking-method-to-achieve-multi-factor-release-from-electrospun-gelatin
#14
Alysha P Kishan, Taneidra Walker, Nick Sears, Thomas Wilems, Elizabeth M Cosgriff-Hernandez
To better mimic native tissue microenvironments, current efforts have moved beyond single growth factor delivery to more complex multiple growth factor delivery with distinct release profiles. Electrospun gelatin, a widely investigated drug delivery vehicle, requires post-processing crosslinking techniques that generate a mesh with uniform crosslinking density, limiting the ability to deliver multiple factors at different rates. Herein, we describe a method to independently control release of multiple factors from a single electrospun gelatin mesh...
January 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29322457/detecting-phenotypically-resistant-mycobacterium-tuberculosis-using-wavelength-modulated-raman-spectroscopy
#15
Vincent O Baron, Mingzhou Chen, Simon O Clark, Ann Williams, Kishan Dholakia, Stephen H Gillespie
Raman spectroscopy is a non-destructive and label-free technique. Wavelength modulated Raman (WMR) spectroscopy was applied to investigate Mycobacterium tuberculosis cell state, lipid rich (LR) and lipid poor (LP). Compared to LP cells, LR cells can be up to 40 times more resistant to key antibiotic regimens. Using this methodology single lipid rich (LR) from lipid poor (LP) bacteria can be differentiated with both high sensitivity and specificity. It can also be used to investigate experimentally infected frozen tissue sections where both cell types can be differentiated...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29321323/hiv-1-vif-s-capacity-to-manipulate-the-cell-cycle-is-species-specific
#16
Edward L Evans, Jordan T Becker, Stephanie L Fricke, Kishan Patel, Nathan M Sherer
Cells derived from mice and other rodents exhibit profound blocks to HIV-1 virion production reflecting species-specific incompatibilities between viral Tat and Rev proteins and essential host factors Cyclin T1 (CCNT1) and Exportin-1 (XPO1, also known as CRM1), respectively. To determine if mouse cell blocks other than CCNT1 and XPO1 affect HIV's post-integration stages, we studied HIV-1NL4-3 gene expression in mouse NIH 3T3 cells modified to constitutively express HIV-1 compatible versions of CCNT1 and XPO1 (3T3...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29318313/preparation-and-characterization-of-chromium-doped-ni-cu-zn-nano-ferrites
#17
Bajarang Laxman Shinde, Laxman Appa Dhale, Venkat S Suryavanshi, Kishan Shankarrao Lohar
Chromium doped Ni-Cu-Zn nano ferrites with chemical formula Ni0.2Cu0.2Zn0.6Fe2-xCrxO4 (x = 0.0, 0.2, 0.4, 0.6, 0.8, and 1.0) were prepared by using sol-gel auto combustion method. The prepared precursors of Chromium substituted Ni-Cu-Zn ferrites were sintered at 500 °C for 4h. Compositional stoichiometry were confirmed from EDAX patterns. The XRD data revealed that the all samples possess a single phase cubic spinel structure. The Lattice constant, X-ray density, hopping lengths and crystallite size determined from XRD data decreases with increase in Cr3+ concentration...
December 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/29298373/an-organic-vortex-laser
#18
Daan Stellinga, Monika E Pietrzyk, James M E Glackin, Yue Wang, Ashu K Bansal, Graham A Turnbull, Kishan Dholakia, Ifor D W Samuel, Thomas F Krauss
Optical vortex beams are at the heart of a number of novel research directions, both as carriers of information and for the investigation of optical activity and chiral molecules. Optical vortex beams are beams of light with a helical wavefront and associated orbital angular momentum. They are typically generated using bulk optics methods or by a passive element such as a forked grating or a metasurface to imprint the required phase distribution onto an incident beam. Since many applications benefit from further miniaturisation, a more integrated yet scalable method is highly desirable...
January 3, 2018: ACS Nano
https://www.readbyqxmd.com/read/29283510/towards-automated-cancer-screening-label-free-classification-of-fixed-cell-samples-using-wavelength-modulated-raman-spectroscopy
#19
Lana Woolford, Mingzhou Chen, Kishan Dholakia, C Simon Herrington
The ability to provide quantitative, objective and automated pathological analysis would provide enormous benefits for national cancer screening programmes, in terms of both resource reduction and improved patient wellbeing. The move towards molecular pathology through spectroscopic methods shows great promise, but has been restricted by spectral quality, acquisition times, and lack of direct clinical application. In this paper, we present the application of wavelength modulated Raman spectroscopy for the automated label- and fluorescence-free classification of fixed squamous epithelial cells in suspension, such as those produced during a cervical smear test...
December 28, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29244194/arid5a-stabilizes-ox40-mrna-in-murine-cd4-t-cells-by-recognizing-a-stem-loop-structure-in-its-3-utr
#20
Hamza Hanieh, Kazuya Masuda, Hozaifa Metwally, Jaya P Chalise, Maged Mohamed, Kishan K Nyati, Daron M Standley, Songling Li, Mitsuru Higa, Mohammad M Zaman, Tadamitsu Kishimoto
AT-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) required for autoimmunity via stabilization of interleukin-6 (Il6) and signal transducer and activator of transcription 3 (STAT3) mRNAs. However, the roles of Arid5a in Th17 cells and its association with autoimmunity remains unknown. Here, we show that the levels of Arid5a and OX40 are correlated in CD4+ T cells under Th17 conditions in an IL-6-dependent manner. Lack of Arid5a in T cells reduced OX40 expression levels and repressed IL-17 production in response to OX40 ligation...
December 15, 2017: European Journal of Immunology
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