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https://www.readbyqxmd.com/read/28330124/somaclonal-variations-and-their-applications-in-horticultural-crops-improvement
#1
REVIEW
Hare Krishna, Mahdi Alizadeh, Dhurendra Singh, Udayvir Singh, Nitesh Chauhan, Maliheh Eftekhari, Radha Kishan Sadh
The advancements made in tissue culture techniques has made it possible to regenerate various horticultural species in vitro as micropropagation protocols for commercial scale multiplication are available for a wide range of crops. Clonal propagation and preservation of elite genotypes, selected for their superior characteristics, require high degree of genetic uniformity amongst the regenerated plants. However, plant tissue culture may generate genetic variability, i.e., somaclonal variations as a result of gene mutation or changes in epigenetic marks...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28301348/discord-among-radiation-oncologists-and-urologists-in-the-postoperative-management-of-high-risk-prostate-cancer
#2
Amar U Kishan, Gillian Duchesne, Pin-Chieh Wang, Jean-Claude M Rwigema, Arun U Kishan, Christopher Saigal, Matthew Rettig, Michael L Steinberg, Christopher R King
OBJECTIVE: To query specialty-specific differences regarding postoperative radiotherapy (RT) for high-risk prostate cancer. MATERIALS AND METHODS: Electronic mail survey of radiation oncologists (ROs) and urologists. We sought to maximize absolute response number to capture contemporary practice ethos. The outcome of interest was association between response and specialty. Training level/expertise, practice setting, percentage of consultation caseload consisting of high-risk prostate cancer, and nationality were set as effect modifiers for multivariate logistic regression...
March 15, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28290712/development-of-olmesartan-medoxomil-lipid-based-nanoparticles-and-nanosuspension-preparation-characterization-and-comparative-pharmacokinetic-evaluation
#3
Arun B, Narendar D, Kishan Veerabrahma
The aim was to enhance the oral bioavailability of olmesartan medoxomil (OM) by preparing solid lipid nanoparticles (SLNs) and comparing with nanosuspension (OM-NS). OM-SLNs and OM-NS were prepared by known methods. Prepared SLNs were evaluated for physical characters and in vivo pharmacokinetic (PK) performance in rats. OM-NS showed more than four-fold increase in the solubility. During DSC and XRD studies, drug incorporated in SLNs was found to be in amorphous form. The relative bioavailability of OM-SLN and OM-NS was 7...
March 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28276891/removal-of-h2s-pollutant-from-gasifier-syngas-by-a-multistage-dual-flow-sieve-plate-column-wet-scrubber
#4
Swamy Kurella, Pawan Kishan Bhukya, B C Meikap
The objective of this study was to observe the performance of a lab-scale three-stage dual-flow sieve plate column scrubber for hydrogen sulfide (H2S) gas removal from a gas stream, in which the H2S concentration was similar to that of gasifier syngas. The tap water was used as scrubbing liquid. The gas and liquid were operated at flow rates in the range of 16.59 × 10(-4)-27.65 × 10(-4) Nm(3)/s and 20.649 × 10(-6)-48.183 × 10(-6) m(3)/s, respectively. The effects of gas and liquid flow rates on the percentage removal of H2S were studied at 50-300 ppm inlet concentrations of H2S...
February 16, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28273084/vitamin-d-deficiency-predicts-infections-in-young-north-indian-children-a-secondary-data-analysis
#5
Ranadip Chowdhury, Sunita Taneja, Nita Bhandari, Bireshwar Sinha, Ravi Prakash Upadhyay, Maharaj Kishan Bhan, Tor A Strand
BACKGROUND: Recent studies have demonstrated a relationship between poor vitamin D status and respiratory infections and diarrhea among young children. Acute lower respiratory infections (ALRI) and diarrhea are among the two most important causes of death in under-5 children. In this paper, we examined the extent to which vitamin-D deficiency (<10 ng/ml) predicts ALRI, clinical pneumonia and diarrhea among 6 to 30 months old children. METHODS: We used data from a randomized controlled trial (RCT) of daily folic acid and/or vitamin B12 supplementation for six months in 6 to 30 months old children conducted in Delhi, India...
2017: PloS One
https://www.readbyqxmd.com/read/28271908/development-of-olmesartan-medoxomil-optimized-nanosuspension-using-box-behnken-design-to-improve-oral-bioavailability
#6
Nagaraj K, Narendar D, Kishan V
The aim of present investigation was to enhance the oral bioavailability of olmesartan medoxomil by improving its solubility and dissolution rate by preparing nanosuspension (OM-NS), using Box-Behnken design. In this, four factors were evaluated at three levels. Independent variables include: concentration of drug (X1), concentration of surfactant (X2), concentration of polymer (X3) and number of homogenization cycles (X4). Based on preliminary studies the size (Y1), zeta potential (Y2) and % drug release at 5min (Y3) were chosen as dependent responses...
March 8, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28256551/multimodal-discrimination-of-immune-cells-using-a-combination-of-raman-spectroscopy-and-digital-holographic-microscopy
#7
Naomi McReynolds, Fiona G M Cooke, Mingzhou Chen, Simon J Powis, Kishan Dholakia
The ability to identify and characterise individual cells of the immune system under label-free conditions would be a significant advantage in biomedical and clinical studies where untouched and unmodified cells are required. We present a multi-modal system capable of simultaneously acquiring both single point Raman spectra and digital holographic images of single cells. We use this combined approach to identify and discriminate between immune cell populations CD4+ T cells, B cells and monocytes. We investigate several approaches to interpret the phase images including signal intensity histograms and texture analysis...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254204/eosinophilia-associated-with-strongyloides-infection-severe-asthma-and-central-bronchiectasis
#8
Kishan Shah, Denisa Ferastraoaru, Sunit Jariwala
No abstract text is available yet for this article.
February 18, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28243379/preemptive-caudal-ropivacaine-an-effective-analgesic-during-degenerative-lumbar-spine-surgery
#9
Shashwat Kumar, Jagannath Manickam Palaniappan, Anantha Kishan
STUDY DESIGN: This was a prospective, randomized, controlled trial comprising 60 patients undergoing lumbosacral spine (noninstrumentation/nonfusion) surgery. PURPOSE: The purpose of this study was to evaluate the efficacy of 0.2% ropivacaine (20 mL) administered alone as a single, preoperative, caudal epidural block injection versus that of intravenous analgesics in providing effective postoperative analgesia to patients undergoing lumbosacral spine surgery. OVERVIEW OF LITERATURE: Various studies have shown the effectiveness of a caudal epidural injection (bupivacaine or ropivacaine) in providing postoperative analgesia in combination with steroids or other analgesics...
February 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28203508/deltoid-compartment-syndrome-a-rare-complication-after-humeral-intraosseous-access
#10
Kishan M Thadikonda, Francesco M Egro, Irene Ma, Alexander M Spiess
We present a case of a 65-year-old woman who developed a delayed deltoid compartment syndrome after resuscitation via humeral intraosseous access. Initially she was treated conservatively but then was taken emergently for a fasciotomy. After confirming the diagnosis with compartment pressures, a 2-incision approach was employed and a large hematoma was evacuated from the inferior margin of the anterior deltoid. The rest of the deltoid was inspected and debrided to healthy bleeding tissue. Her fasciotomy wounds were left open to heal on their own due to her tenuous clinical condition...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28182411/solvothermal-synthesis-of-cu2sns3-quantum-dots-and-their-application-in-near-infrared-photodetectors
#11
Sandra Dias, Kishan Kumawat, Shinjini Biswas, Salaru Babu Krupanidhi
Cu2SnS3 (CTS) quantum dots were synthesized by solvothermal technique with poly(vinylpyrrolidone) (PVP) as a surfactant. The structural and optical properties were studied using X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectroscopy, and UV-vis spectroscopy. The electronic band gap was measured using cyclic voltammetry. The infrared photoresponse of the CTS quantum dots-incorporated device was measured under different illumination intensities of the infrared lamp, 1550 and 1064 nm lasers...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28178376/treatment-trends-for-patients-with-brain-metastases-does-practice-reflect-the-data
#12
Kiri A Sandler, Narek Shaverdian, Ryan R Cook, Amar U Kishan, Christopher R King, Isaac Yang, Michael L Steinberg, Percy Lee
BACKGROUND: Published guidelines regarding the optimal treatment strategies for brain metastases focus on patients with ≤3 lesions. As delivery techniques for stereotactic radiosurgery (SRS) improve, radiation oncologists are increasingly using it for patients with >3 metastases. In the current study, the authors sought to characterize practice patterns among practitioners to identify areas of controversy. METHODS: A survey of practicing radiation oncologists was distributed via e-mail...
February 8, 2017: Cancer
https://www.readbyqxmd.com/read/28168301/tlr4-induced-nf-%C3%AE%C2%BAb-and-mapk-signaling-regulate-the-il-6-mrna-stabilizing-protein-arid5a
#13
Kishan K Nyati, Kazuya Masuda, Mohammad Mahabub-Uz Zaman, Praveen K Dubey, David Millrine, Jaya P Chalise, Mitsuru Higa, Songling Li, Daron M Standley, Kazunobu Saito, Hamza Hanieh, Tadamitsu Kishimoto
No abstract text is available yet for this article.
February 7, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28149710/associations-of-objectively-measured-moderate-to-vigorous-intensity-physical-activity-and-sedentary-time-with-all-cause-mortality-in-a-population-of-adults-at-high-risk-of-type-2-diabetes-mellitus
#14
Kishan Bakrania, Charlotte L Edwardson, Kamlesh Khunti, Joseph Henson, Emmanuel Stamatakis, Mark Hamer, Melanie J Davies, Thomas Yates
The relationships of physical activity and sedentary time with all-cause mortality in those at high risk of type 2 diabetes mellitus (T2DM) are unexplored. To address this gap in knowledge, we examined the associations of objectively measured moderate-to-vigorous-intensity physical activity (MVPA) and sedentary time with all-cause mortality in a population of adults at high risk of T2DM. In 2010-2011, 712 adults (Leicestershire, U.K.), identified as being at high risk of T2DM, consented to be followed up for mortality...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28126301/exploring-value-from-the-patient-s-perspective-between-modern-radiation-therapy-modalities-for-localized-prostate-cancer
#15
Narek Shaverdian, Darlene Verruttipong, Pin-Chieh Wang, Amar U Kishan, D Jeffrey Demanes, Susan McCloskey, Patrick Kupelian, Michael L Steinberg, Christopher R King
PURPOSE: Patients' perspectives on their treatment experiences have not been compared between modern radiation modalities for localized prostate cancer. We evaluated treatment regret and patients' perceptions of their treatment experiences to better inform our understanding of a treatment's value. METHODS AND MATERIALS: Patients with localized prostate cancer treated with stereotactic body radiation therapy (SBRT), intensity modulated radiation therapy (IMRT), or high-dose-rate (HDR) brachytherapy between 2008 and 2014 with at least 1 year of follow-up were surveyed...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28117147/accelerometer-wear-site-detection-when-one-site-does-not-suit-all-all-of-the-time
#16
Alex V Rowlands, Tim S Olds, Kishan Bakrania, Rebecca M Stanley, Gaynor Parfitt, Roger G Eston, Thomas Yates, François Fraysse
OBJECTIVES: Choice of accelerometer wear-site may facilitate greater compliance in research studies. We aimed to test whether a simple method could automatically discriminate whether an accelerometer was worn on the hip or wrist from free-living data. DESIGN: Cross-sectional. METHODS: Twenty-two 10-12y old children wore a GENEActiv at the wrist and at the hip for 7-days. The angle between the forearm and the total acceleration vector for the wrist-worn monitor and between the pelvis and the total acceleration vector for the hip-worn monitor (i...
May 21, 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28088883/candesartan-cilexetil-loaded-nanodelivery-systems-for-improved-oral-bioavailability
#17
Narendar Dudhipala, Kishan Veerabrahma
Candesartan cilexetil (CC), an antihypertensive drug, has low oral bioavailability due to poor solubility and hepatic first-pass metabolism. These are major limitations in oral delivery of CC. Several approaches are known to reduce the problems of solubility and improve the bioavailability of CC. Among various approaches, nanotechnology-based delivery of CC has potential to overcome the challenges associated with the oral administration. This review focuses on various nano-based delivery systems available and tried for improving the aqueous solubility, dissolution and consequently bioavailability of CC upon oral administration...
February 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28087555/associations-of-reallocating-sitting-time-into-standing-or-stepping-with-glucose-insulin-and-insulin-sensitivity-a-cross-sectional-analysis-of-adults-at-risk-of-type-2-diabetes
#18
Charlotte L Edwardson, Joe Henson, Danielle H Bodicoat, Kishan Bakrania, Kamlesh Khunti, Melanie J Davies, Thomas Yates
OBJECTIVE: To quantify associations between sitting time and glucose, insulin and insulin sensitivity by considering reallocation of time into standing or stepping. DESIGN: Cross-sectional. SETTING: Leicestershire, UK, 2013. PARTICIPANTS: Adults aged 30-75 years at high risk of impaired glucose regulation (IGR) or type 2 diabetes. 435 adults (age 66.8±7.4 years; 61.7% male; 89.2% white European) were included. METHODS: Participants wore an activPAL3 monitor 24 hours/day for 7 days to capture time spent sitting, standing and stepping...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28048191/su-f-j-135-tumor-displacement-based-binning-for-respiratory-gated-time-independent-5dct-treatment-planning
#19
L Yang, D O'Connell, P Lee, N Shaverdian, A Kishan, J Lewis, T Dou, D Thomas, X Qi, D Low
PURPOSE: A published 5DCT breathing motion model enables image reconstruction at any user-selected breathing phase, defined by the model as a specific amplitude (v) and rate (f). Generation of reconstructed phase-specific CT scans will be required for time-independent radiation dose distribution simulations. This work answers the question: how many amplitude and rate bins are required to describe the tumor motion with a specific spatial resolution? METHODS: 19 lung-cancer patients with 21 tumors were scanned using a free-breathing 5DCT protocol, employing an abdominally positioned pneumatic-bellows breathing surrogate and yielding voxel-specific motion model parameters α and β corresponding to motion as a function of amplitude and rate, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047606/su-g-bra-04-simulation-of-errors-in-maximal-intensity-projection-mip-based-lung-tumor-internal-target-volumes-itv-using-real-time-2d-mri-and-deformable-image-registration-based-lung-tumor-tracking
#20
D Thomas, A Kishan, A Santhanam, Y Min, D O'Connell, J Lamb, M Cao, N Agazaryan, Y Yang, P Lee, D Low
PURPOSE: To evaluate the effect of inter- and intra-fractional tumor motion on the error in four-dimensional computed tomography (4DCT) maximal intensity projection (MIP)-based lung tumor internal target volumes (ITV), using deformable image registration of real-time 2D-sagital cine-mode MRI acquired during lung SBRT treatments. METHODS: Five lung tumor patients underwent free breathing SBRT treatment on the ViewRay, with dose prescribed to PTV (4DCT MIP-based ITV+3-6mm margin)...
June 2016: Medical Physics
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