keyword
MENU ▼
Read by QxMD icon Read
search

Kishan

keyword
https://www.readbyqxmd.com/read/28088883/candesartan-cilexetil-loaded-nanodelivery-systems-for-improved-oral-bioavailability
#1
Narendar Dudhipala, Kishan Veerabrahma
Candesartan cilexetil (CC), an antihypertensive drug, has low oral bioavailability due to poor solubility and hepatic first-pass metabolism. These are major limitations in oral delivery of CC. Several approaches are known to reduce the problems of solubility and improve the bioavailability of CC. Among various approaches, nanotechnology-based delivery of CC has potential to overcome the challenges associated with the oral administration. This review focuses on various nano-based delivery systems available and tried for improving the aqueous solubility, dissolution and consequently bioavailability of CC upon oral administration...
February 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28087555/associations-of-reallocating-sitting-time-into-standing-or-stepping-with-glucose-insulin-and-insulin-sensitivity-a-cross-sectional-analysis-of-adults-at-risk-of-type-2-diabetes
#2
Charlotte L Edwardson, Joe Henson, Danielle H Bodicoat, Kishan Bakrania, Kamlesh Khunti, Melanie J Davies, Thomas Yates
OBJECTIVE: To quantify associations between sitting time and glucose, insulin and insulin sensitivity by considering reallocation of time into standing or stepping. DESIGN: Cross-sectional. SETTING: Leicestershire, UK, 2013. PARTICIPANTS: Adults aged 30-75 years at high risk of impaired glucose regulation (IGR) or type 2 diabetes. 435 adults (age 66.8±7.4 years; 61.7% male; 89.2% white European) were included. METHODS: Participants wore an activPAL3 monitor 24 hours/day for 7 days to capture time spent sitting, standing and stepping...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28048191/su-f-j-135-tumor-displacement-based-binning-for-respiratory-gated-time-independent-5dct-treatment-planning
#3
L Yang, D O'Connell, P Lee, N Shaverdian, A Kishan, J Lewis, T Dou, D Thomas, X Qi, D Low
PURPOSE: A published 5DCT breathing motion model enables image reconstruction at any user-selected breathing phase, defined by the model as a specific amplitude (v) and rate (f). Generation of reconstructed phase-specific CT scans will be required for time-independent radiation dose distribution simulations. This work answers the question: how many amplitude and rate bins are required to describe the tumor motion with a specific spatial resolution? METHODS: 19 lung-cancer patients with 21 tumors were scanned using a free-breathing 5DCT protocol, employing an abdominally positioned pneumatic-bellows breathing surrogate and yielding voxel-specific motion model parameters α and β corresponding to motion as a function of amplitude and rate, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047606/su-g-bra-04-simulation-of-errors-in-maximal-intensity-projection-mip-based-lung-tumor-internal-target-volumes-itv-using-real-time-2d-mri-and-deformable-image-registration-based-lung-tumor-tracking
#4
D Thomas, A Kishan, A Santhanam, Y Min, D O'Connell, J Lamb, M Cao, N Agazaryan, Y Yang, P Lee, D Low
PURPOSE: To evaluate the effect of inter- and intra-fractional tumor motion on the error in four-dimensional computed tomography (4DCT) maximal intensity projection (MIP)-based lung tumor internal target volumes (ITV), using deformable image registration of real-time 2D-sagital cine-mode MRI acquired during lung SBRT treatments. METHODS: Five lung tumor patients underwent free breathing SBRT treatment on the ViewRay, with dose prescribed to PTV (4DCT MIP-based ITV+3-6mm margin)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28017867/fabrication-of-macromolecular-gradients-in-aligned-fiber-scaffolds-using-a-combination-of-in-line-blending-and-air-gap-electrospinning
#5
Alysha P Kishan, Andrew B Robbins, Sahar F Mohiuddin, Mingliang Jiang, Michael R Moreno, Elizabeth M Cosgriff-Hernandez
: Although a variety of fabrication methods have been developed to generate electrospun meshes with gradient properties, no platform has yet to achieve fiber alignment in the direction of the gradient that mimics the native tendon-bone interface. In this study, we present a method combining in-line blending and air-gap electrospinning to address this limitation in the field. A custom collector with synced rotation permitted fiber collection with uniform mesh thickness and periodic copper wires were used to induce fiber alignment...
December 22, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28012335/is-the-absence-of-right-hepatic-vein-opening-into-inferior-vena-cava-a-contraindication-for-right-lobe-liver-donation-in-living-donor-liver-transplantation-common-hepatic-venous-trunk-a-rare-hepatic-vein-anomaly-a-case-report-and-review
#6
Samrat Ray, T Anila, Sandeep Kumar Jha, Saumitra Rawat, Kishan Singh Rawat, Suresh Kumar Singhvi
INTRODUCTION: In majority of the living liver donors, the left and the middle hepatic veins form a common trunk and the right hepatic vein drains by a separate trunk into the IVC forming two ostial openings. PRESENTATION OF CASE: This report presents a rare challenge to the operating surgeon in which the three major hepatic veins form a common trunk and drain into the IVC through a single ostial opening. It was detected preoperatively by the routine donor imaging studies...
November 18, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27997685/urinary-toxicity-after-stereotactic-body-radiotherapy-the-boy-who-cried-wolf
#7
Amar U Kishan, Patrick A Kupelian, Michael L Steinberg, Christopher R King
No abstract text is available yet for this article.
December 20, 2016: Cancer
https://www.readbyqxmd.com/read/27984489/intraobserver-and-interobserver-measurement-variability-of-the-rib-vertebral-angle-difference
#8
Robert G Tysklind, Karen Myung, George Gantsoudes, Shyam Kishan, Chad Turner, Stella Lee, Matthew Wanner, Meagan Sabatino, Scott Linger, Randall T Loder
BACKGROUND: The rib-vertebral angle (RVAD) differentiates between progressive and resolving infantile idiopathic scoliosis (IIS) curves. Those with a RVAD<20 degrees often resolve without treatment, whereas those >20 degrees often progress and require treatment. The mathematical magnitude of RVAD measurement variability has not been described, and was thus the purpose of this study. It is important to know the reliability of RVAD measurements so as to understand changes that can be attributed to observer error alone...
December 14, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27966892/rotational-dynamics-and-heating-of-trapped-nanovaterite-particles
#9
Yoshihiko Arita, Joseph M Richards, Michael Mazilu, Gabriel C Spalding, Susan E Skelton Spesyvtseva, Derek Craig, Kishan Dholakia
We synthesize, optically trap, and rotate individual nanovaterite crystals with a mean particle radius of 423 nm. Rotation rates of up to 4.9 kHz in heavy water are recorded. Laser-induced heating due to residual absorption of the nanovaterite particle results in the superlinear behavior of the rotation rate as a function of trap power. A finite element method based on the Navier-Stokes model for the system allows us to determine the residual optical absorption coefficient for a trapped nanovaterite particle...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27964987/analysis-of-the-contaminants-released-from-municipal-solid-waste-landfill-site-a-case-study
#10
S R Samadder, R Prabhakar, D Khan, D Kishan, M S Chauhan
Release and transport of leachate from municipal solid waste landfills pose a potential hazard to both surrounding ecosystems and human populations. In the present study, soil, groundwater, and surface water samples were collected from the periphery of a municipal solid waste landfill (located at Ranital of Jabalpur, Madhya Pradesh, India) for laboratory analysis to understand the release of contaminants. The landfill does not receive any solid wastes for dumping now as the same is under a landfill closure plan...
December 10, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27957560/auditory-and-nonauditory-effects-of-ultrasonic-scaler-use-and-its-role-in-the-development-of-permanent-hearing-loss
#11
Aditi Chopra, Betsy S Thomas, Kishan Mohan, Karthik Sivaraman
PURPOSE: To evaluate the negative auditory and non-auditory effects developed immediately after using ultrasonic scalers and their potential role in the development of permanent hearing loss. MATERIALS AND METHODS: The auditory functions of 60 dental clinicians were evaluated with the pure tone audiometry test (PTA), tympanogram and the otoacoustic emission test (OAE) before and immediately after using ultrasonic scalers. The paired t-test was used to evaluate the difference in the pre- and post-exposure recordings for all three tests...
2016: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/27904197/myelitis-a-rare-neurological-complication-of-herpes-zoster
#12
Monika Mohanbhai Agrawal, Rashmi Samir Mahajan, Freny Erachshaw Bilimoria, Kishan Rasubhai Ninama
No abstract text is available yet for this article.
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27872540/glomangiopericytoma-versus-solitary-fibrous-tumor-an-omental-tumor-with-unusual-diagnostic-dilemma
#13
K Jayaprakash Shetty, Chandrika Rao, H L Kishan Prasad
No abstract text is available yet for this article.
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27867712/enhancement-of-image-quality-and-imaging-depth-with-airy-light-sheet-microscopy-in-cleared-and-non-cleared-neural-tissue
#14
Jonathan Nylk, Kaley McCluskey, Sanya Aggarwal, Javier A Tello, Kishan Dholakia
We have investigated the effect of Airy illumination on the image quality and depth penetration of digitally scanned light-sheet microscopy in turbid neural tissue. We used Fourier analysis of images acquired using Gaussian and Airy light-sheets to assess their respective image quality versus penetration into the tissue. We observed a three-fold average improvement in image quality at 50 μm depth with the Airy light-sheet. We also used optical clearing to tune the scattering properties of the tissue and found that the improvement when using an Airy light-sheet is greater in the presence of stronger sample-induced aberrations...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27857464/the-abernethy-malformation-myriad-imaging-manifestations-of-a-single-entity
#15
Samarjit S Ghuman, Saumya Gupta, T B S Buxi, Kishan S Rawat, Anurag Yadav, Naimish Mehta, Seema Sud
Abernethy malformation, also known as congenital extrahepatic portosystemic shunts (CEPS) is a rare clinical entity and manifests with different clinical symptoms. CEPS are abnormalities of vascular development where there is shunting of portal blood into the systemic venous system. Multidetector computed tomography (MDCT) is a fast and effective modality for evaluation of CEPS. CT displays all the information desired by the surgeon as well as the clinician including the anatomy of the splenic and superior mesenteric veins, size and site of the shunt, presence or absence of the portal vein radicles, and helps to plan the therapy and even the follow-up of these patients...
July 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27856691/optical-spectroscopic-analysis-for-the-discrimination-of-extra-virgin-olive-oil
#16
Naomi McReynolds, Juan M Auñón Garcia, Zoe Guengerich, Terry K Smith, Kishan Dholakia
We demonstrate the ability to discriminate between five brands of commercially available extra-virgin olive oil (EVOO) using Raman spectroscopy or fluorescence spectroscopy. Data was taken on both a 'bulk optics' free space system and on a compact handheld device, each capable of taking both Raman and fluorescence data. With the compact Raman device we achieved an average sensitivity and specificity of 98.4% and 99.6% for discrimination, respectively. Our approach illustrates that both Raman and fluorescence spectroscopy can be used for portable discrimination of EVOOs...
November 2016: Applied Spectroscopy
https://www.readbyqxmd.com/read/27847410/effect-of-feeding-guar-meal-on-nutrient-utilization-and-growth-performance-in-mahbubnagar-local-kids
#17
Razia Sultana Janampet, Kishan Kumar Malavath, Rajanna Neeradi, Satyanarayana Chedurupalli, Raghunandan Thirunahari
AIM: This study was conducted to evaluate the growth performance and nutrient digestibility of guar meal, an unconventional protein-rich feed ingredient in kids in comparison to conventional groundnut cake. MATERIALS AND METHODS: A total of 18 kids were randomly allotted to three groups, and T1 group was fed on basal diet, T2 and T3 groups were offered diet replacing groundnut cake at 50% and 100% with guar meal, respectively, for a period of 120-day. At the end of the growth trial, a digestibility trial was conducted to evaluate the nutrient utilization...
October 2016: Veterinary World
https://www.readbyqxmd.com/read/27810472/improved-anti-hyperlipidemic-activity-of-rosuvastatin-calcium-via-lipid-nanoparticles-pharmacokinetic-and-pharmacodynamic-evaluation
#18
Narendar Dudhipala, Kishan Veerabrahma
The intent of this investigation was to improve pharmacokinetic (PK) and pharmacodynamic (PD) effects of Rosuvastatin calcium (RC) by solid lipid nanoparticles (SLNs). RC is anti-hyperlipidemic drug with low oral bioavailability (20%) due to first-pass metabolism. Hot homogenization followed by ultrasonication method was used to prepare RC-SLNs with stearic acid, glyceryl behenate and glyceryl trilaurate as lipid matrices, egg lecithin and poloxamer 188 as surfactants. The prepared SLNs were tested for particle size, PDI, zeta potential (ZP), entrapment efficiency (EE), drug content and in vitro release...
January 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27766317/myocardial-architecture-and-patient-variability-in-clinical-patterns-of-atrial-fibrillation
#19
Kishan A Manani, Kim Christensen, Nicholas S Peters
Atrial fibrillation (AF) increases the risk of stroke by a factor of 4-5 and is the most common abnormal heart rhythm. The progression of AF with age, from short self-terminating episodes to persistence, varies between individuals and is poorly understood. An inability to understand and predict variation in AF progression has resulted in less patient-specific therapy. Likewise, it has been a challenge to relate the microstructural features of heart muscle tissue (myocardial architecture) with the emergent temporal clinical patterns of AF...
October 2016: Physical Review. E
https://www.readbyqxmd.com/read/27732993/radiation-therapy-for-stage-i-nonoperable-or-medically-inoperable-lung-cancer
#20
Amar U Kishan, Percy Lee
Non-small cell lung cancer (NSCLC) is the second most common solid malignancy in the United States of America, and the leading cause of cancer-related mortality. Nearly 15% of patients present with early-stage disease, for which the standard of care is lobectomy. However, the median age at diagnosis ranges from 65 to 74 years, and many patients have significant comorbidities that preclude surgical treatment. Previously, the standard of care for these patients was definitive radiotherapy (RT) with conventional fractionation (i...
October 2016: Seminars in Respiratory and Critical Care Medicine
keyword
keyword
13943
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"