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https://www.readbyqxmd.com/read/29244194/arid5a-stabilizes-ox40-mrna-in-murine-cd4-t-cells-by-recognizing-a-stem-loop-structure-in-its-3-utr
#1
Hamza Hanieh, Kazuya Masuda, Hozaifa Metwally, Jaya P Chalise, Maged Mohamed, Kishan K Nyati, Daron M Standley, Songling Li, Mitsuru Higa, Mohammad M Zaman, Tadamitsu Kishimoto
AT-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) required for autoimmunity via stabilization of interleukin-6 (Il6) and signal transducer and activator of transcription 3 (STAT3) mRNAs. However, the roles of Arid5a in Th17 cells and its association with autoimmunity remains unknown. Here, we show that the levels of Arid5a and OX40 are correlated in CD4+ T cells under Th17 conditions in an IL-6-dependent manner. Lack of Arid5a in T cells reduced OX40 expression levels and repressed IL-17 production in response to OX40 ligation...
December 15, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29228042/risk-of-thromboembolism-in-cisplatin-versus-carboplatin-treated-patients-with-lung-cancer
#2
Eric S Kim, Andrea M Baran, Esther L Mondo, Thomas D Rodgers, Gradon C Nielsen, David W Dougherty, Kishan J Pandya, David Q Rich, Edwin van Wijngaarden
INTRODUCTION: Carboplatin is widely used to treat lung cancer in the United States as an alternative to cisplatin. Several studies have demonstrated that cisplatin-based regimen is associated with a high frequency of thromboembolic complications. However, there has been limited investigation directly comparing the risk of thromboembolic events (TEEs) between cisplatin- and carboplatin-treated patients with lung cancer. METHODS: All lung cancer patients treated with cisplatin or carboplatin at Wilmot Cancer Center, University of Rochester between 2011 and 2014 were included...
2017: PloS One
https://www.readbyqxmd.com/read/29207811/comparative-evaluation-of-ropivacaine-and-fentanyl-versus-ropivacaine-and-fentanyl-with-clonidine-for-postoperative-epidural-analgesia-in-total-knee-replacement-surgery
#3
Shivali Panwar, Preeti S Govind, Parag Jyoti Duarah, Hari Kishan Mahajan, Smita Anil Korde
Introduction: Clonidine an alpha 2 adrenoceptor agonist possesses analgesic properties and has been used as an adjuvant in epidural analgesia. The addition of clonidine to other analgesics may result in enhanced analgesia through additive mechanisms or synergistic mechanisms. The enhanced analgesia may lead to a decrease in the dosage of analgesic drugs along with reduction of side effects. Aim: The purpose of this study was to evaluate the effect of adding clonidine to epidural ropivacaine and fentanyl mixture in terms of quality of analgesia and side effects in patients of total knee replacement surgery...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29194966/the-use-of-custom-made-dental-splints-for-robotic-and-rigid-endoscopic-surgery-of-the-upper-aerodigestive-tract
#4
Kishan Ubayasiri, Wai Sum Cho, Paul Smith, Robin Thorpe, Mohamed-Shaji Mansuri, David Laugharne, Sean Mortimore
Custom made dental splints allow for significantly improved access in difficult cases, especially those involving the laser or robot. Our customization also allows bespoke accommodation of the Boyle Davis gag or FK-retractor. These guards never displace and afford protection to the otherwise exposed lower teeth. The dental splints are reusable. This article is protected by copyright. All rights reserved.
December 1, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29188203/comparison-of-visual-prostate-symptom-score-and-international-prostate-symptom-score-in-the-evaluation-of-men-with-benign-prostatic-hyperplasia-a-prospective-study-from-an-indian-population
#5
Yogesh Taneja, Priyatama Ram, Satish Kumar, Kishan Raj, Charan K Singh, Santosh K Dhaked, Jiten Jaipuria
Background: Lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) are common conditions in middle-age or older men. The International Prostate Symptom Score (IPSS) is a useful and validated questionnaire to evaluate LUTS secondary to BPH. Van der Walt et al have developed an alternative questionnaire named the Visual Prostate Symptom Score (VPSS) questionnaire. This study aimed to evaluate the relationship between the VPSS and IPSS in the evaluation of men with LUTSs due to BPH in an Indian population...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29188112/multimode-fibre-based-imaging-for-optically-cleared-samples
#6
Ivan Gusachenko, Jonathan Nylk, Javier A Tello, Kishan Dholakia
Optical clearing is emerging as a popular approach particularly for studies in neuroscience. However the use of corrosive clearing solutions typically requires sophisticated objectives or extreme care with optical components chosen for single- or multi-photon imaging. In contrast to the use of complex, custom-made microscope objectives, we show that the use of a corrected multimode fibre (MMF) offers a route that is resistant to corrosion, can be used in clearing media, is not constrained by the refractive index of the immersion medium and offers flexible working distances...
November 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29181347/pelvic-hydatid-disease-a-case-report-and-review-of-literature
#7
Nishit Bhatnagar, Hari Kishan, Sumit Sura, Purushotham Lingaiah, Kameshwaran Jaikumar
Introduction: Cystic echinococcosis of the bone is rare and difficult to treat due to frequent recurrences, especially in certain locations such as ilium and hip, where radical surgery is difficult to achieve. Case Report: We present a case of a 35-year-old female of the Indian subcontinent who had complaints of pain in left hip and limp since 1 year. The first clinical and radiological diagnosis was tuberculosis of the hip. However, higher imaging modalities revealed the diagnosis of hydatid disease of hip...
July 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29166129/initial-observations-of-intra-and-inter-fractional-motion-variation-in-mr-guided-lung-sbrt
#8
David H Thomas, Anand Santhanam, Amar U Kishan, Minsong Cao, James Lamb, Yugang Min, Dylan O'Connell, Yingli Yang, Nzhde Agazaryan, Percy Lee, Daniel Low
OBJECTIVE: To evaluate variations in intra- and inter-fractional tumor motion, and the effect on ITV contour accuracy, using deformable image registration of real-time 2D-sagital cine-mode MRI acquired during lung SBRT treatments. METHODS: Five lung tumor patients underwent free breathing SBRT treatments on the ViewRay system, with dose prescribed to a planning target volume (PTV; defined as a 3-6 mm expansion of the 4DCT-ITV). Sagittal slice cine-MR images (3.5x3...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29157133/reallocating-sitting-time-to-standing-or-stepping-through-isotemporal-analysis-associations-with-markers-of-chronic-low-grade-inflammation
#9
Joseph Henson, Charlotte L Edwardson, Danielle H Bodicoat, Kishan Bakrania, Melanie J Davies, Kamlesh Khunti, Duncan C S Talbot, Thomas Yates
Although high levels of sitting time are adversely related to health, it is unclear whether moving from sitting to standing provides a sufficient stimulus to elicit benefits upon markers of chronic low-grade inflammation in a population at high risk of type 2 diabetes (T2DM). Three hundred and seventy two participants (age = 66.8 ± 7.5years; body mass index (BMI) = 31.7 ± 5.5kg/m(2); Male = 61%) were included. Sitting, standing and stepping was determined using the activPAL3(TM) device. Linear regression modelling employing an isotemporal substitution approach was used to quantify the association of theoretically substituting 60 minutes of sitting per day for standing or stepping on interleukin-6 (IL-6), C-reactive protein (CRP) and leptin...
November 21, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29144506/soluble-p-selectin-promotes-retinal-ganglion-cell-survival-through-activation-of-nrf2-signaling-after-ischemia-injury
#10
Kishan Kapupara, Yao-Tseng Wen, Rong-Kung Tsai, Shun-Ping Huang
Retinal ischemic injuries play an important role in the pathogenesis of several eye disorders. Inflammation and oxidative stress are key players in ischemic injuries. Following retinal ischemia, vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules. P-selectin stimulates leukocyte recruitment to platelet aggregates and has an important role in vascular homeostasis and inflammatory leukocyte extravasation. Soluble P-selectin can be neuroprotective through competitive binding to the receptors of endogenous P-selectin molecules...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29124986/development-of-zolmitriptan-transfersomes-by-box-behnken-design-for-nasal-delivery-in-vitro-and-in-vivo-evaluation
#11
Sravan Kumar Pitta, Narendar Dudhipala, Arjun Narala, Kishan Veerabrahma
The aim was to prepare an optimized zolmitriptan (ZT) loaded transfersome formulation using Box-Behnken design for improving the bioavailability by nasal route for quick relief of migraine and further to compare with a marketed nasal spray. Here, three factors were evaluated at three levels. Independent variables include: amount of soya lecithin (X1), amount of drug (X2) and amount of tween 80 (X3). The dependent responses were vesicle size (Y1), flexibility index (Y2) and regression co-efficient of drug release kinetics (Y3)...
November 10, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29123013/-68-ga-psma-pet-ct-mapping-of-prostate-cancer-biochemical-recurrence-following-radical-prostatectomy-in-270-patients-with-psa-1-0ng-ml-impact-on-salvage-radiotherapy-planning
#12
Jérémie Calais, Johannes Czernin, Minsong Cao, Amar U Kishan, John V Hegde, Narek Shaverdian, Kiri A Sandler, Fang-I Chu, Chris R King, Michael L Steinberg, Isabel Rausher, Nina-Sophie Schmidt-Hegemann, Thorsten Poeppel, Philipp Hetkamp, Francesco Ceci, Ken Herrmann, Wolfgang P Fendler, Matthias Eiber, Nicholas G Nickols
Background: Target volume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy are usually drawn in the absence of visibly recurrent disease. Gallium-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography ((68)Ga-PSMA-11 PET/CT) detects recurrent PCa with sensitivity superior to standard of care imaging at serum prostate specific antigen (PSA) values low enough to impact target volume delineations for routine SRT. OBJECTIVE: To i) map the recurrence pattern of PCa early biochemical recurrence (BCR) after radical prostatectomy with (68)Ga-PSMA-11 PET/CT in patients with serum PSA levels <1 ng/ml, ii) determine how often consensus clinical target volumes (CTV) based on the Radiation Therapy Oncology Group (RTOG) guidelines cover (68)Ga-PSMA-11 PET/CT-defined disease, and iii) assess the potential impact of (68)Ga-PSMA-11 PET/CT on SRT...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29118700/looking-beyond-the-cyclosporine-swish-and-spit-technique-in-a-recalcitrant-case-of-erosive-lichen-planus-involving-the-tongue
#13
Aastha Gupta, Kabir Sardana, Ram Kishan Gautam
Oral lichen planus is a relatively common autoimmune disease affecting the middle-aged population. Although no treatment is necessary for a benign asymptomatic case, in case of erosive lichen planus, topical corticosteroids form the mainstay of treatment. In case of failure, apart from tacrolimus, cyclosporine, using the "swish and spit" technique, is a valid therapeutic intervention. In our case, though, this therapeutic option had to be replaced by the systemic use of cyclosporine with gratifying results.
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29114284/intraoperative-magnetic-resonance-imaging-for-cranial-and-spinal-cases-using-preexisting-c-shaped-three-side-open-0-2-tesla-magnetic-resonance-imaging
#14
Vinod Kumar Tewari, Ravindra Tripathi, Subodh Aggarwal, Mazhar Hussain, Hari Kishan Das Gupta
Background: The existing Intraoperative MRI (IMRI) of developed countries is too costly to be affordable in any developing country and out of the reach of common and poor people of developing country at remote areas. We have used the pre-existing (refurbished) 3 side open "C" shaped 0.2 Tesla MRI for IMRI in a very remote area. Materials and Methods: In this technique the 0.2 Tesla MRI and the operating theatre were merged. MRI table was used as an operation table...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29104835/online-adaptive-radiation-therapy-implementation-of-a-new-process-of-care
#15
James Lamb, Minsong Cao, Amar Kishan, Nzhde Agazaryan, David H Thomas, Narek Shaverdian, Yingli Yang, Suzette Ray, Daniel A Low, Ann Raldow, Michael L Steinberg, Percy Lee
Onboard magnetic resonance imaging (MRI) guided radiotherapy is now clinically available in nine centers in the world. This technology has facilitated the clinical implementation of online adaptive radiotherapy (OART), or the ability to alter the daily treatment plan based on tumor and anatomical changes in real-time while the patient is on the treatment table. However, due to the time sensitive nature of OART, implementation in a large and busy clinic has many potential obstacles as well as patient-related safety considerations...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29091090/from-electroburning-to-sublimation-substrate-and-environmental-effects-in-the-electrical-breakdown-process-of-monolayer-graphene
#16
Maria El Abbassi, László Pósa, Péter Makk, Cornelia Nef, Kishan Thodkar, András Halbritter, Michel Calame
We report on the characterization of the electrical breakdown (EB) process for the formation of tunneling nanogaps in single-layer graphene. In particular, we investigated the role of oxygen in the breakdown process by varying the environmental conditions (vacuum and ambient conditions). We show that the density of oxygen molecules in the chamber is a crucial parameter that defines the physical breakdown process: at low density, the graphene lattice is sublimating, whereas at high density, the process involved is oxidation, independent of the substrate material...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29042058/exercise-induced-complete-atrioventricular-block-utility-of-exercise-stress-test
#17
Srikanth Yandrapalli, Prakash Harikrishnan, Amole Ojo, Venkat Lakshmi Kishan Vuddanda, Diwakar Jain
Exercise induced complete atrioventricular block (EIAVB) is a relatively uncommon condition. This phenomenon is clinically important because it can mimic symptoms of other cardiovascular conditions and may be associated with exercise intolerance and subsequent syncope. A 76year old man with long-standing hypertension and diabetes mellitus presented with recurrent episodes of lightheadedness and syncope with physical activity. ECG showed sinus rhythm with first degree atrioventricular block. Echocardiography did not show any valvular disease causing his symptoms...
September 10, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29020281/association-of-walking-pace-and-handgrip-strength-with-all-cause-cardiovascular-and-cancer-mortality-a-uk-biobank-observational-study
#18
Thomas Yates, Francesco Zaccardi, Nafeesa N Dhalwani, Melanie J Davies, Kishan Bakrania, Carlos A Celis-Morales, Jason M R Gill, Paul W Franks, Kamlesh Khunti
Aims: To quantify the association of self-reported walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality. Methods and results: A total of 230 670 women and 190 057 men free from prevalent cancer and cardiovascular disease were included from UK Biobank. Usual walking pace was self-defined as slow, steady/average or brisk. Handgrip strength was assessed by dynamometer. Cox-proportional hazard models were adjusted for social deprivation, ethnicity, employment, medications, alcohol use, diet, physical activity, and television viewing time...
November 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28992036/associations-between-sedentary-behaviours-and-cognitive-function-cross-sectional-and-prospective-findings-from-the-uk-biobank
#19
Kishan Bakrania, Charlotte L Edwardson, Kamlesh Khunti, Stephan Bandelow, Melanie J Davies, Thomas Yates
We investigate the cross-sectional and prospective associations between different sedentary behaviours and cognitive function in a large sample of UK Biobank adults. Baseline data were available on 502,643 participants (years 2006-2010). Cognitive tests included prospective memory [n = 171,585 (baseline only)], visual-spatial memory [round 1 (n = 483,832); round 2 (n = 482,762)], fluid intelligence [n = 165,492], and short-term numeric memory [n = 50,370]. After a mean period of 5.3-years, between 12,091 and 114,373 participants also provided follow-up cognitive data...
July 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28989886/comparative-evaluation-of-safety-and-efficacy-of-glimepiride-and-sitagliptin-in-combination-with-metformin-in-patients-with-type-2-diabetes-mellitus-indian-multicentric-randomized-trial-start-study
#20
T V Devarajan, S Venkataraman, Narayanan Kandasamy, Abraham Oomman, Hari Kishan Boorugu, S K P Karuppiah, Dushyant Balat
BACKGROUND AND OBJECTIVE: Modern sulfonylureas like glimepiride offer effective glycemic control with extrapancreatic benefits and good tolerability. The objective of the present study was to evaluate and compare safety and efficacy of glimepiride and sitagliptin in combination with metformin in patients with type 2 diabetes mellitus (T2DM). METHODS: In this open-label, randomized, comparative, multicenter study, a total of 305 T2DM patients who were either drug naïve or uncontrolled on metformin were randomized to glimepiride 1 or 2 mg/sustained-release metformin 1000 mg once daily (glimepiride group, n = 202) or sitagliptin 50 mg/metformin 500 mg twice daily (sitagliptin group, n = 103) for 12 weeks...
September 2017: Indian Journal of Endocrinology and Metabolism
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