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https://www.readbyqxmd.com/read/29656222/prolactin-induced-protein-pip-is-a-potential-biomarker-for-early-stage-and-malignant-breast-cancer
#1
Anju Gangadharan, Themba Nyirenda, Kishan Patel, Nydia Jaimes-Delgadillo, Dominique Coletta, Takemi Tanaka, Ayal C Walland, Zena Jameel, Srinivasa Vedantam, Sittinon Tang, Ciaran Mannion, Grace Y Lee, Andre Goy, Andrew Pecora, K Stephen Suh
OBJECTIVES: Breast cancer (BC) is the second leading cause of cancer-related mortality in women. Bioinformatic analysis and expression screening showed that Prolactin Induced Protein (PIP) was differentially expressed in BC. The objective of this investigation was to characterize the expression pattern of PIP, an aspartyl proteinase, in malignant and non-malignant breast tissues. MATERIALS AND METHODS: Real time quantitative PCR was employed to analyze PIP and androgen receptor (AR) mRNA levels in BC cell lines and 190 normal tissues and tumor samples...
April 12, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29628640/biocompatibility-and-sealing-ability-of-mineral-trioxide-aggregate-and-biodentine-as-root-end-filling-material-a-systematic-review
#2
REVIEW
Nidhi Pravinchandra Solanki, Kishan Karkala Venkappa, Nimisha Chinmay Shah
Introduction: This systematic review intended to compare the biocompatibility and sealing ability of mineral trioxide aggregate (MTA) and biodentine as root-end filling material. Materials and Methods: A computerized literature search was performed on March 1, 2016, in MEDLINE, PubMed, and COCHRANE LIBRARY for data published from January 2011 to March 2016. Quality assessment of the selected studies was performed according to the PRISMA guidelines, 2009. Results: A total of 12 in vitro studies were included in this review...
January 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29595831/condensing-embryology-teaching-a-medical-student-perspective
#3
COMMENT
Sachin T Patel, Sagar Dodhia, Kishan P Parekh
No abstract text is available yet for this article.
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29578893/in-reply-comparison-of-efficacy-and-complications-of-cyclophotocoagulation-and-second-glaucoma-drainage-device-after-initial-glaucoma-drainage-device-failure
#4
Lauren S Blieden, Margaret Y Wang, Kishan Patel, Alice Z Chuang, Laura A Baker, Nicholas P Bell, Robert M Feldman
No abstract text is available yet for this article.
March 23, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29578872/68ga-prostate-specific-membrane-antigen-pet-ct-in-triple-negative-breast-cancer
#5
Averilicia Passah, Saurabh Arora, Nishikant Avinash Damle, Madhavi Tripathi, Chandrasekhar Bal, T Kishan Subudhi, Geetanjali Arora
The prostate-specific membrane antigen (PSMA) is a transmembrane protein with elevated expression in prostate cancer cells. Breast cancer also shows PSMA expression. We present the case of a 30-year-old woman with triple-negative bilateral breast carcinoma who underwent bilateral mastectomy, chemotherapy, and radiotherapy. She developed a left chest wall and liver recurrence after primary therapy. Her recurrent disease was also triple-negative. In view of the known poor prognosis and very limited therapeutic options, we performed Ga-PSMA PET/CT scan to explore the possibility of PSMA-based therapy as a future option after exhausting standard-of-care treatments...
March 24, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29578081/effective-cellular-internalization-cell-cycle-arrest-and-improved-pharmacokinetics-of-tamoxifen-by-cholesterol-based-lipopolymeric-nanoparticles
#6
Samrat Mazumdar, Kishan S Italiya, Saurabh Sharma, Deepak Chitkara, Anupama Mittal
The present study aims at the development of cholesterol based lipopolymeric nanoparticles for improved entrapment, better cell penetration and improved pharmacokinetics of Tamoxifen (TMX). Self-assembling cholesterol grafted lipopolymer, mPEG-b-(CB-{g-chol}-co-LA) was synthesized from poly(ethyleneglycol)-block-2-methyl-2-carboxyl-propylenecarboxylic acid-co-poly (L-lactide) [mPEG-b-(CB-{g-COOH}-co-LA)] copolymer followed by carbodiimide coupling for attaching cholesterol. Lipopolymeric nanoparticleswere prepared using o/w solvent evaporation technique, which were subsequently characterized to determine its particle size, entrapment efficiency, release pattern and compared with mPEG-PLA nanoparticles...
March 22, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29543547/a-phase-4-multicentre-randomized-single-blind-clinical-trial-to-evaluate-the-immunogenicity-of-the-live-attenuated-oral-rotavirus-vaccine-116e-rotavac%C3%A2-administered-simultaneously-with-or-without-the-buffering-agent-in-healthy-infants-in-india
#7
Raches Ella, Radhika Bobba, Sanjay Muralidhar, Sudhir Babji, Krishna Mohan Vadrevu, Maharaj Kishan Bhan
BACKGROUND: The World Health Organization recommends that rotavirus vaccines should be included in all national immunization programs. Some currently licensed oral rotavirus vaccines contain a buffering agent (either as part of a ready-to-use liquid formulation or added during reconstitution) to reduce possible degradation of the vaccine virus in the infant gut, which poses several programmatic challenges (the large dose volume or the reconstitution requirement) during vaccine administration...
March 15, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29541827/biochemical-and-genetic-analyses-of-n-metabolism-in-maize-testcross-seedlings-2-roots
#8
Ignacio Trucillo Silva, Hari Kishan R Abbaraju, Lynne P Fallis, Hongjun Liu, Michael Lee, Kanwarpal S Dhugga
Intracellular factors differentially affected enzyme activities of N assimilation in the roots of maize testcrosses where alanine aminotransferase and glutamate synthase were the main enzymes regulating the levels of glutamate. N is a key macronutrient for plant growth and development. Breeding maize with improved efficiency in N use could help reduce environmental contamination as well as increase profitability for the farmers. Quantitative trait loci (QTL) mapping of traits related to N metabolism in the root tissue was undertaken in a maize testcross mapping population grown in hydroponic cultures...
March 14, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29534640/overdue-to-understand-anticoagulation-in-pulmonary-arterial-hypertension
#9
Kishan S Parikh, Michael P Gray, Lewis J Rubin, David Badesch, Richard A Krasuski
No abstract text is available yet for this article.
January 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29516926/sonographic-imaging-of-fibrosis-of-oral-mucosa-and-its-correlation-with-clinical-staging-in-oral-submucous-fibrosis
#10
Lakshmi Kavitha Nadendla, Venkat Kishan Tatikonda, Balaji Babu Bangi, Harsha Bhayya, Revath Vyas Devulapally, Archana Pokala
Background and Objectives: To evaluate the efficacy of ultrasonography (USG) as a noninvasive tool in assessing the severity of oral submucous fibrosis (OSMF) by measuring the submucosal thickness and also to correlate the sonographic changes with clinical staging. Materials and Methods: The submucosal thickness of the upper and lower labial mucosa, anterior and posterior portions of the right and left buccal mucosa were measured using ultrasound in 64 patients comprising of 32 OSMF patients and 32 controls...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29509865/radical-prostatectomy-external-beam-radiotherapy-or-external-beam-radiotherapy-with-brachytherapy-boost-and-disease-progression-and-mortality-in-patients-with-gleason-score-9-10-prostate-cancer
#11
MULTICENTER STUDY
Amar U Kishan, Ryan R Cook, Jay P Ciezki, Ashley E Ross, Mark M Pomerantz, Paul L Nguyen, Talha Shaikh, Phuoc T Tran, Kiri A Sandler, Richard G Stock, Gregory S Merrick, D Jeffrey Demanes, Daniel E Spratt, Eyad I Abu-Isa, Trude B Wedde, Wolfgang Lilleby, Daniel J Krauss, Grace K Shaw, Ridwan Alam, Chandana A Reddy, Andrew J Stephenson, Eric A Klein, Daniel Y Song, Jeffrey J Tosoian, John V Hegde, Sun Mi Yoo, Ryan Fiano, Anthony V D'Amico, Nicholas G Nickols, William J Aronson, Ahmad Sadeghi, Stephen Greco, Curtiland Deville, Todd McNutt, Theodore L DeWeese, Robert E Reiter, Johnathan W Said, Michael L Steinberg, Eric M Horwitz, Patrick A Kupelian, Christopher R King
Importance: The optimal treatment for Gleason score 9-10 prostate cancer is unknown. Objective: To compare clinical outcomes of patients with Gleason score 9-10 prostate cancer after definitive treatment. Design, Setting, and Participants: Retrospective cohort study in 12 tertiary centers (11 in the United States, 1 in Norway), with 1809 patients treated between 2000 and 2013. Exposures: Radical prostatectomy (RP), external beam radiotherapy (EBRT) with androgen deprivation therapy, or EBRT plus brachytherapy boost (EBRT+BT) with androgen deprivation therapy...
March 6, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29500922/electrodermal-response-to-auditory-stimuli-in-relation-to-menopausal-transition-period
#12
Ashwini Kishan, Nikitha Marakur, Shailaja Moodithaya, Amrit M Mirajkar
BACKGROUND: Menopause-associated estrogen deficiency results in climacteric symptoms like vasomotor, psychological and sleep disturbances that cause a decline in the quality of life. Electrodermal activity (EDA), a psychophysiological measure, reflects sympathetic activity, which provides information associated with individual's emotions, phobias, arousal, cognition and stress. The study compared electrodermal response to auditory stimuli between postmenopausal and perimenopausal women with and without symptoms and also correlated the association of scores of the menopausal transition symptoms with indices of EDA...
March 28, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29498496/re-thinking-knowledge-landscapes-in-the-context-of-grounded-aboriginal-theory-and-online-health-communication
#13
Kishan Kariippanon, Kate Senior
No abstract text is available yet for this article.
February 28, 2018: Croatian Medical Journal
https://www.readbyqxmd.com/read/29493812/bet-proteins-in-abnormal-metabolism-inflammation-and-the-breast-cancer-microenvironment
#14
REVIEW
Guillaume P Andrieu, Jordan S Shafran, Jude T Deeney, Kishan R Bharadwaj, Annapoorni Rangarajan, Gerald V Denis
Obesity and its associated pathology Type 2 diabetes are two chronic metabolic and inflammatory diseases that promote breast cancer progression, metastasis, and poor outcomes. Emerging critical opinion considers unresolved inflammation and abnormal metabolism separately from obesity; settings where they do not co-occur can inform disease mechanism. In breast cancer, the tumor microenvironment is often infiltrated with T effector and T regulatory cells programmed by metabolic signaling. The pathways by which tumor cells evade immune surveillance, immune therapies, and take advantage of antitumor immunity are poorly understood, but likely depend on metabolic inflammation in the microenvironment...
March 1, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29490939/lite-microscopy-tilted-light-sheet-excitation-of-model-organisms-offers-high-resolution-and-low-photobleaching
#15
Tanner C Fadero, Therese M Gerbich, Kishan Rana, Aussie Suzuki, Matthew DiSalvo, Kristina N Schaefer, Jennifer K Heppert, Thomas C Boothby, Bob Goldstein, Mark Peifer, Nancy L Allbritton, Amy S Gladfelter, Amy S Maddox, Paul S Maddox
Fluorescence microscopy is a powerful approach for studying subcellular dynamics at high spatiotemporal resolution; however, conventional fluorescence microscopy techniques are light-intensive and introduce unnecessary photodamage. Light-sheet fluorescence microscopy (LSFM) mitigates these problems by selectively illuminating the focal plane of the detection objective by using orthogonal excitation. Orthogonal excitation requires geometries that physically limit the detection objective numerical aperture (NA), thereby limiting both light-gathering efficiency (brightness) and native spatial resolution...
February 28, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29450742/focused-cardiac-ultrasound-as-a-predictor-of-readmission-in-acute-decompensated-heart-failure
#16
Luke J Laffin, Amit V Patel, Narayan Saha, Julian Barbat, James K Hall, Matthew Cain, Kishan Parikh, Jay Shah, Kirk T Spencer
Acute decompensated heart failure (ADHF) is a common reason for admission to the hospital, and readmission is frequent. Multiple factors contribute to rehospitalizations, but inadequate assessment of volume status leading to persistent congestion is an important factor. We sought to determine if focused cardiac ultrasound (FCU) of the inferior vena cava (IVC), as a surrogate of volume status, would predict readmission of ADHF patients after index hospitalization. Patients admitted with a primary diagnosis of ADHF were prospectively enrolled...
February 15, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29447890/outcomes-of-adenoidectomy-alone-in-patients-less-than-3-years-old
#17
Kishan M Thadikonda, Amber D Shaffer, Amanda L Stapleton
OBJECTIVES: 1. Determine the percentage of patients under the age of 3 undergoing adenoidectomy-alone who require subsequent management of residual sleep disordered breathing (SDB).2. Characterize complications following adenoidectomy and determine if any perioperative factors are associated with intra-operative or post-operative complications and outcomes. METHODS: Case series with chart review was conducted including children seen at a tertiary care children's hospital between 2008 and 2012...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29436393/therapeutically-targeting-tumor-microenvironment-mediated-drug-resistance-in-estrogen-receptor-positive-breast-cancer
#18
Kevin Shee, Wei Yang, John W Hinds, Riley A Hampsch, Frederick S Varn, Nicole A Traphagen, Kishan Patel, Chao Cheng, Nicole P Jenkins, Arminja N Kettenbach, Eugene Demidenko, Philip Owens, Anthony C Faber, Todd R Golub, Ravid Straussman, Todd W Miller
Drug resistance to approved systemic therapies in estrogen receptor-positive (ER+) breast cancer remains common. We hypothesized that factors present in the human tumor microenvironment (TME) drive drug resistance. Screening of a library of recombinant secreted microenvironmental proteins revealed fibroblast growth factor 2 (FGF2) as a potent mediator of resistance to anti-estrogens, mTORC1 inhibition, and phosphatidylinositol 3-kinase inhibition in ER+ breast cancer. Phosphoproteomic analyses identified ERK1/2 as a major output of FGF2 signaling via FGF receptors (FGFRs), with consequent up-regulation of Cyclin D1 and down-regulation of Bim as mediators of drug resistance...
February 7, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29429921/comparison-of-lung-tumor-motion-measured-using-a-model-based-4dct-technique-and-a-commercial-protocol
#19
Dylan O'Connell, Narek Shaverdian, Amar U Kishan, David H Thomas, Tai H Dou, John H Lewis, James M Lamb, Minsong Cao, Stephen Tenn, Lee P Percy, Daniel A Low
PURPOSE: To compare lung tumor motion measured with a model-based technique to commercial 4-dimensional computed tomography (4DCT) scans and describe a workflow for using model-based 4DCT as a clinical simulation protocol. METHODS AND MATERIALS: Twenty patients were imaged using a model-based technique and commercial 4DCT. Tumor motion was measured on each commercial 4DCT dataset and was calculated on model-based datasets for 3 breathing amplitude percentile intervals: 5th to 85th, 5th to 95th, and 0th to 100th...
November 11, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29423177/immunization-practices-in-low-birth-weight-infants-from-rural-haryana-india-findings-from-secondary-data-analysis
#20
Ravi Prakash Upadhyay, Ranadip Chowdhury, Sarmila Mazumder, Sunita Taneja, Bireshwar Sinha, Jose Martines, Rajiv Bahl, Nita Bhandari, Maharaj Kishan Bhan
Background: Low birth weight (LBW) infants constitute a vulnerable subset of infants with impaired immunity in early life. In India, there is scarcity of studies that focus on immunization practices in such infants. This analysis aimed to examine immunization practices in LBW infants with the intention to identify areas requiring intervention. Methods: Data on immunization status of LBW infants enrolled in an individually randomized, double-masked, placebo-controlled trial of neonatal vitamin A supplementation were analysed...
December 2017: Journal of Global Health
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