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Kishan A Manani, Kim Christensen, Nicholas S Peters
Atrial fibrillation (AF) increases the risk of stroke by a factor of 4-5 and is the most common abnormal heart rhythm. The progression of AF with age, from short self-terminating episodes to persistence, varies between individuals and is poorly understood. An inability to understand and predict variation in AF progression has resulted in less patient-specific therapy. Likewise, it has been a challenge to relate the microstructural features of heart muscle tissue (myocardial architecture) with the emergent temporal clinical patterns of AF...
October 2016: Physical Review. E
Amar U Kishan, Percy Lee
Non-small cell lung cancer (NSCLC) is the second most common solid malignancy in the United States of America, and the leading cause of cancer-related mortality. Nearly 15% of patients present with early-stage disease, for which the standard of care is lobectomy. However, the median age at diagnosis ranges from 65 to 74 years, and many patients have significant comorbidities that preclude surgical treatment. Previously, the standard of care for these patients was definitive radiotherapy (RT) with conventional fractionation (i...
October 2016: Seminars in Respiratory and Critical Care Medicine
Esther Rani P, N Kishan
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Timothy E Audas, Danielle E Audas, Mathieu D Jacob, J J David Ho, Mireille Khacho, Miling Wang, J Kishan Perera, Caroline Gardiner, Clay A Bennett, Trajen Head, Oleksandr N Kryvenko, Mercé Jorda, Sylvia Daunert, Arun Malhotra, Laura Trinkle-Mulcahy, Mark L Gonzalgo, Stephen Lee
The amyloid state of protein organization is typically associated with debilitating human neuropathies and is seldom observed in physiology. Here, we uncover a systemic program that leverages the amyloidogenic propensity of proteins to regulate cell adaptation to stressors. On stimulus, cells assemble the amyloid bodies (A-bodies), nuclear foci containing heterogeneous proteins with amyloid-like biophysical properties. A discrete peptidic sequence, termed the amyloid-converting motif (ACM), is capable of targeting proteins to the A-bodies by interacting with ribosomal intergenic noncoding RNA (rIGSRNA)...
October 4, 2016: Developmental Cell
Kishan Bakrania, Thomas Yates, Alex V Rowlands, Dale W Esliger, Sarah Bunnewell, James Sanders, Melanie Davies, Kamlesh Khunti, Charlotte L Edwardson
OBJECTIVES: (1) To develop and internally-validate Euclidean Norm Minus One (ENMO) and Mean Amplitude Deviation (MAD) thresholds for separating sedentary behaviours from common light-intensity physical activities using raw acceleration data collected from both hip- and wrist-worn tri-axial accelerometers; and (2) to compare and evaluate the performances between the ENMO and MAD metrics. METHODS: Thirty-three adults [mean age (standard deviation (SD)) = 27.4 (5.9) years; mean BMI (SD) = 23...
2016: PloS One
Vernon Bond, Bryan H Curry, Krishna Kumar, Sudhakar Pemminati, Vasavi R Gorantla, Kishan Kadur, Richard M Millis
OBJECTIVES: Acupuncture treatments are safe and effective for a wide variety of diseases involving autonomic dysregulation. Heart rate variability (HRV) is a noninvasive method for assessing sympathovagal balance. The low frequency/high frequency (LF/HF) spectral power ratio is an index of sympathovagal influence on heart rate and of cardiovascular health. This study tests the hypothesis that from rest to 30% to 50% of peak oxygen consumption, the nonlinear Conte-Zbilut-Federici (CZF) method of computing the LF/HF ratio is a more reliable index of changes in the HRV than linear methods are...
September 2016: Journal of Pharmacopuncture
Kishan S Parikh, Melissa A Greiner, Takeki Suzuki, Adam D DeVore, Chad Blackshear, Joseph F Maher, Lesley H Curtis, Adrian F Hernandez, Emily C O'Brien, Robert J Mentz
Importance: Increased resting heart rate is associated with worse outcomes in studies of mostly white populations, but its significance is not well established in African Americans persons whose cardiac comorbidities and structural abnormalities differ. Objective: To study the prognostic utility of heart rate in a community-based African American cohort in the Jackson Heart Study. Design, Setting, and Participants: A total of 5261 participants in the Jackson Heart Study, a prospective, community-based study in Jackson, Mississippi, were evaluated...
September 28, 2016: JAMA Cardiology
D O'Connell, N Shaverdian, A U Kishan, D H Thomas, L Yang, J Lewis, J M Lamb, M Cao, S E Tenn, P Lee, D Low
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
J D D Pennington, A U Kishan, A M Chen
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
N Shaverdian, J Demanes, D Veruttipong, J Wang, A U Kishan, S A McCloskey, P A Kupelian, M L Steinberg, C R King
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
A U Kishan, T Shaikh, J Wang, R Reiter, J Said, G Raghavan, N Nickols, W Aronson, A Sadeghi, M Kamrava, D J Demanes, M L Steinberg, E M Horwitz, P A Kupelian, C R King
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
A U Kishan, J Wang, J C Rwigema, C Saigal, M Rettig, M L Steinberg, C R King
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Anudeep Sandanamudi, Kishan R Bharadwaj, Radha Cheruppanpullil
Chitin binding activity of moringa seed resistant protein (MSRP) isolated from defatted moringa seed flour was investigated in the present study "Characterization of soluble dietary fiber from Moringa oleifera seeds and its immunomodulatory effects" (S. Anudeep, V.K. Prasanna, S.M. Adya, C. Radha, 2016) [1]. The assay reaction mixture contained 0.4 mg/ml of MSRP and different amounts (20-100 mg) of chitin. MSRP exhibited binding activity over wide range of chitin concentration. Maximum binding activity was observed at 80 mg of chitin...
December 2016: Data in Brief
Mohammad Mahabub-Uz Zaman, Kazuya Masuda, Kishan Kumar Nyati, Praveen Kumar Dubey, Barry Ripley, Kai Wang, Jaya Prakash Chalise, Mitsuru Higa, Hamza Hanieh, Tadamitsu Kishimoto
Adenine-thymine (AT)-rich interactive domain containing protein 5a (Arid5a) is an RNA-binding protein that has been shown to play an important immune regulatory function via the stabilization of IL-6 and STAT3 mRNA. However, the role of Arid5a in the overwhelming and uncontrolled immune response that leads to septic shock is unknown. Here, we report that Arid5a-deficient mice are highly resistant to lipopolysaccharide (LPS)-induced endotoxic shock and secrete lower levels of major proinflammatory cytokines, including IFN-γ, IL-6, and TNF-α, than WT mice in response to LPS...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
G S H Ramakanth, C Uday Kumar, P V Kishan, P Usharani
BACKGROUND: Root extracts of Withania somnifera (Ashwagandha) are known to possess analgesic, anti-inflammatory and chondroprotective effects. An aqueous extract of roots plus leaves of this plant has shown to yield higher percentages of withanolide glycosides and, accordingly, may possess better analgesic, anti-inflammatory and chondroprotective effects than root alone extracts. OBJECTIVES: To evaluate efficacy and tolerability of a standardized aqueous extract of roots plus leaves of W...
July 2016: Journal of Ayurveda and Integrative Medicine
Bryan Heath Curry, Vernon Bond, Sudhakar Pemminati, Vasavi Rakesh Gorantla, Yulia Andreevna Volkova, Kishan Kadur, Richard Mark Millis
INTRODUCTION: Beetroot Juice (BJ) contains dietary nitrates that increase the blood Nitric Oxide (NO) level, decrease Blood Pressure (BP), increase athletic performance and improve cognitive functions but the mechanism remains unclear. Ultrasonographic measurement of middle cerebral artery blood flow velocity with computation of Cerebral Augmentation Index (CAIx) is a measure of the reflected flow signal, modulated by changes in cerebrovascular resistance and compliance. AIM: This pilot study tests the hypothesis that ingestion of an amount of BJ sufficient to raise the blood NO level two-to three-fold, decreases Transcranial Doppler (TCD) measured CAIx...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Venkata Kishan Pokuri, Chiranjeevi Uday Kumar, Usharani Pingali
BACKGROUND AND AIMS: To evaluate analgesic activity and safety of single oral dose (1000 mg) of Terminalia chebula using a mechanical pain model in healthy human volunteers. MATERIAL AND METHODS: Twelve healthy volunteers were randomized to receive either single oral dose of 2 capsules of T. chebula 500 mg each or identical placebo capsules in a double-blinded manner. Mechanical pain was assessed using Ugo basile analgesy meter (Randall-Selitto test) before and 3 h after administration of test drug...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
Amar U Kishan, Caitlin L Gomez, Nicole A Dawson, Robyn Dvorak, Nova M Foster, Anne Hoyt, Sara A Hurvitz, Amy Kusske, Erica L Silver, Charles Tseng, Susan A McCloskey
BACKGROUND: Findings show that 5-10 % of women with a diagnosis of breast cancer (BCa) have actionable genetic mutations. The National Comprehensive Cancer Network guidelines for testing to detect BRCA1/2 mutations include personal history (PH) variables such as age of 45 years or younger and a family history (FH) variables. Rates of FH documentation and overall rates of appropriate referral for genetic testing are low, ranging from about 30 to 60 %. The authors hypothesized that an upfront FH documentation and inclusion of a genetics counselor in a multidisciplinary clinic (MDC) setting would increase rates of appropriate referral for genetic testing...
September 12, 2016: Annals of Surgical Oncology
Matthew D Oleksiak, Arian Ghorbanpour, Marlon T Conato, B Peter McGrail, Lars C Grabow, Radha Kishan Motkuri, Jeffrey D Rimer
Designing zeolites with tunable physicochemical properties can substantially impact their performance in commercial applications, such as adsorption, separations, catalysis, and drug delivery. Zeolite synthesis typically requires an organic structure-directing agent to produce crystals with specific pore topology. Attempts to remove organics from syntheses to achieve commercially viable methods of preparing zeolites often lead to the formation of impurities. Herein, we present organic-free syntheses of two polymorphs of the small-pore zeolite P (GIS), P1 and P2...
November 2, 2016: Chemistry: a European Journal
Surinder Pal Singh, Satinder Pal Singh, Jai Kishan, Sumeet Kaur, Shandhra Ramana
INTRODUCTION: The association of Tuberculosis and Diabetes Mellitus is a cause of concern for the health sector. The coexistence of these two highly prevalent diseases has made the already existing treatments very complex. This issue is of particular significance to developing countries like India that bear a significant burden of these two diseases. METHODS: Retrospective analysis of 1000 consecutively admitted patients in a tertiary care hospital were analyzed for the coexistence of Tuberculosis and Diabetes Mellitus...
2016: Pan African Medical Journal
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