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https://www.readbyqxmd.com/read/29759994/what-s-happening-in-neurology-%C3%A2-neuroimmunology-neuroinflammation
#1
(no author information available yet)
No abstract text is available yet for this article.
May 15, 2018: Neurology
https://www.readbyqxmd.com/read/29747820/gangliosides-and-autoimmune-peripheral-nerve-diseases
#2
John A Goodfellow, Hugh J Willison
A wide range of neuroimmunological diseases, referred to as autoimmune neuropathies, affect the peripheral nervous systems (PNS). The PNS is structurally diverse with complex anatomical compartments enriched in many different myelin and neuronal glycolipids, notably gangliosides. Autoimmune neuropathies are a proportion of autoimmune neuropathies mediated by autoimmune attack due to antibodies reactive with these compartmentally localized gangliosides. Antiganglioside antibodies are principally associated with the acute paralytic disease, Guillain-Barré syndrome, and are also found in several chronic autoimmune neuropathy syndromes...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29743585/evaluating-the-temperature-effects-of-ice-and-heat-tests-on-ptosis-due-to-myasthenia-gravis
#3
Emmanuel Marinos, Katherine Buzzard, Clare L Fraser, Stephen Reddel
AIMS: The aims of this study are as follows: (1) to describe a standardised methodology for the ice test, and where necessary a heat test; (2) to determine the effects of local cooling vs. heating on ptosis in myasthenia gravis (MG) patients. METHODS: Twenty-three MG patients with ptosis were identified from a tertiary referral neuroimmunology clinic, seventeen with significant ptosis ≥2 mm. Latex party balloons were filled with ice and cold tap water for the ice test, or with water heated to 45 °C for the heat test...
May 10, 2018: Eye
https://www.readbyqxmd.com/read/29738432/neuroimmunology-research-a-report-from-the-cuban-network-of-neuroimmunology
#4
María de Los Angeles Robinson-Agramonte, Lourdes Lorigados Pedre, Orlando Ramón Serrano-Barrera
Neuroimmunology can be traced back to the XIX century through the descriptions of some of the disease’s models (e.g., multiple sclerosis and Guillain Barret syndrome, amongst others). The diagnostic tools are based in the cerebrospinal fluid (CSF) analysis developed by Quincke or in the development of neuroimmunotherapy with the earlier expression in Pasteur’s vaccine for rabies. Nevertheless, this field, which began to become delineated as an independent research area in the 1940s, has evolved as an innovative and integrative field at the shared edges of neurosciences, immunology, and related clinical and research areas, which are currently becoming a major concern for neuroscience and indeed for all of the scientific community linked to it...
May 8, 2018: Behavioral Sciences
https://www.readbyqxmd.com/read/29735769/what-s-happening-in-neurology-%C3%A2-neuroimmunology-neuroinflammation
#5
(no author information available yet)
No abstract text is available yet for this article.
May 8, 2018: Neurology
https://www.readbyqxmd.com/read/29712804/what-s-happening-in-neurology-%C3%A2-neuroimmunology-neuroinflammation
#6
(no author information available yet)
No abstract text is available yet for this article.
May 1, 2018: Neurology
https://www.readbyqxmd.com/read/29706957/microglia-and-beyond-innate-immune-cells-as-regulators-of-brain-development-and-behavioral-function
#7
REVIEW
Kathryn M Lenz, Lars H Nelson
Innate immune cells play a well-documented role in the etiology and disease course of many brain-based conditions, including multiple sclerosis, Alzheimer's disease, traumatic brain and spinal cord injury, and brain cancers. In contrast, it is only recently becoming clear that innate immune cells, primarily brain resident macrophages called microglia, are also key regulators of brain development. This review summarizes the current state of knowledge regarding microglia in brain development, with particular emphasis on how microglia during development are distinct from microglia later in life...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29705849/application-of-chemogenetics-and-optogenetics-to-dissect-brain-immune-interactions
#8
Ben Korin, Asya Rolls
For many years, the complexity and multifactorial nature of brain-immune interactions limited our ability to dissect their underlying mechanisms. An especially challenging question was how the brain controls immunity, since the repertoire of techniques to control the brain's activity was extremely limited. New tools, such as optogenetics and chemogenetics (e.g., DREADDs), developed over the last decade, opened new frontiers in neuroscience with major implications for neuroimmunology. These tools enable mapping the causal effects of activating/attenuating defined neurons in the brain, on the immune system...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29705167/stiff-person-syndrome-with-evidence-of-non-specific-focal-myositis-secondary-to-sustained-muscle-contraction-a-case-report
#9
Seung-Wook No, Il-Gyu Lim, Du Hwan Kim
Stiff person syndrome (SPS) is a rare neuroimmunological disorder characterized by progressive muscular rigidity and spasms that affect axial and limb muscles. There have been a few reports that patients with SPS had evidences of polymyositis (PM). There have been no clear explanations about the characteristics of PM in SPS. We report the case of a 36-year-old woman with SPS in association with non-specific focal myositis secondary to sustained muscle contraction. She presented with stiffness and pain in her extremities, and diazepam and baclofen were ineffective...
April 26, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29691724/neuroimmunologic-and-neurotrophic-interactions-in-autism-spectrum-disorders-relationship-to-neuroinflammation
#10
REVIEW
Kshama Ohja, Evelyne Gozal, Margaret Fahnestock, Lu Cai, Jun Cai, Jonathan H Freedman, Andy Switala, Ayman El-Baz, Gregory Neal Barnes
Autism spectrum disorders (ASD) are the most prevalent set of pediatric neurobiological disorders. The etiology of ASD has both genetic and environmental components including possible dysfunction of the immune system. The relationship of the immune system to aberrant neural circuitry output in the form of altered behaviors and communication characterized by ASD is unknown. Dysregulation of neurotrophins such as BDNF and their signaling pathways have been implicated in ASD. While abnormal cortical formation and autistic behaviors in mouse models of immune activation have been described, no one theory has been described to link activation of the immune system to specific brain signaling pathways aberrant in ASD...
April 24, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29686115/what-s-happening-in-neurology-%C3%A2-neuroimmunology-neuroinflammation
#11
(no author information available yet)
No abstract text is available yet for this article.
April 24, 2018: Neurology
https://www.readbyqxmd.com/read/29667698/chronic-stress-social-isolation-and-perceived-loneliness-in-dementia-caregivers
#12
Mariya Kovaleva, Sydney Spangler, Carolyn Clevenger, Kenneth Hepburn
Caregivers of individuals with dementia are at risk for chronic stress and social isolation. These exogenous factors may lead to perceived stress and perceived loneliness-psychosocial endogenous (subjective) elements of caregiving experience. Chronic stress and perceived loneliness may disrupt neuroendocrine and neuroimmunological regulation, creating low-grade systemic inflammation, promoting proinflammatory gene expression, and expediting cellular aging (endogenous physiological factors). These disturbances may enhance caregivers' risk for chronic conditions of inflammatory pathogenesis...
April 17, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29661891/what-s-happening-in-neurology-%C3%A2-neuroimmunology-neuroinflammation
#13
(no author information available yet)
No abstract text is available yet for this article.
April 17, 2018: Neurology
https://www.readbyqxmd.com/read/29656188/inhibition-of-the-dopamine-transporter-as-an-animal-model-of-bipolar-disorder-mania-locomotor-response-neuroimmunological-profile-and-pharmacological-modulation
#14
Juliana R Bastos, Katherinne M Perico, Érica L Marciano Vieira, Antônio L Teixeira, Fabiana S Machado, Aline S de Miranda, Fabrício A Moreira
Inhibition of dopamine transporter (DAT) by GBR12909 has been proposed as a pharmacological model of mania related to bipolar disorder (BD). Here we tested the hypothesis that GBR12909 injection impairs habituation and induces hyperlocomotion in mice, along with changes in cytokines and neurotrophic factors levels, as observed in BD patients. We also tested if lithium carbonate, sodium valproate and aripiprazole prevent GBR12909-induced locomotion. Male Swiss mice received GBR12909 (15 mg/kg) injections and locomotor responses were quantified in an open field...
April 6, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29653378/possible-origins-of-consciousness-in-simple-control-over-involuntary-neuroimmunological-action
#15
REVIEW
Kevin B Clark
The origin(s) and purpose(s) of consciousness continue to be fervently debated by neuroscientists. A recent unconventional hypothesis put forth by Morsella et al. suggests the primary function of consciousness is the integration, selection, and execution of advantageous lower-level voluntary skeletal muscle behavior on surrounding external environments. However, at main issue is whether more precise, adaptable voluntary skeletal motor action, and therefore the corresponding workings of consciousness, first emerged and evolved in animals to exert control over external environments or internal ones regulated by less flexible autonomic function...
April 10, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29629942/paediatric-multiple-sclerosis-and-other-acute-demyelinating-diseases
#16
Kevin Rostásy, Barbara Bajer-Kornek
PURPOSE OF REVIEW: Neuroimmunological diseases encompass a wide spectrum of diseases in children. Apart from the discovery of autoantibodies affecting primarily grey matter structures and the improved clinical characterization of rare entities such as N-methyl D-aspartate receptor-R- encephalitis, important strides have also been made in autoimmune-mediated white matter diseases, including paediatric multiple sclerosis (pedMS) and other acute demyelinating syndromes (ADS) often associated with antibodies (abs) against myelin-oligodendrocyte-glycoprotein (MOG)...
June 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29616233/normal-brain-imaging-accompanies-neuroimmunologically-justified-autoimmune-encephalomyelitis
#17
Daiki Takewaki, Youwei Lin, Wakiro Sato, Hirohiko Ono, Masakazu Nakamura, Manabu Araki, Tomoko Okamoto, Yuji Takahashi, Yukio Kimura, Miho Ota, Noriko Sato, Takashi Yamamura
Objective: To examine cases with a clinical course, signs, and symptoms mimicking MS, but without abnormalities on conventional MRI. Methods: Among 550 people with a tentative diagnosis of MS or neuromyelitis optica spectrum disorder (NMOSD), we selected patients, who met the 2010 McDonald diagnosis criteria for MS, but did not show abnormal findings on conventional brain and spinal cord MRI. After evaluating their clinical data, we analyzed fractional anisotropy (FA) values in the brain white matter on diffusion tensor MRIs and the frequencies of B-cell subsets in the peripheral blood in the corresponding cases as compared to healthy controls...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29611538/neuroimmunology-are-naturally-occurring-anti-nmdar-autoantibodies-pathogenic
#18
Keiko Tanaka
No abstract text is available yet for this article.
April 3, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29610226/what-s-happening-in-neurology-%C3%A2-neuroimmunology-neuroinflammation
#19
(no author information available yet)
No abstract text is available yet for this article.
April 3, 2018: Neurology
https://www.readbyqxmd.com/read/29606296/corrigendum-to-low-dosage-of-rituximab-in-chinese-patients-with-neuromyelitis-optica-spectrum-disorder-journal-of-neuroimmunology-317c-2018-pp-1-4
#20
J Lin, X Li, B Xue, Q Tong, Z Chen, W Zhu, J Li, J Xia
No abstract text is available yet for this article.
May 15, 2018: Journal of Neuroimmunology
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