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Neuroimmunology

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https://www.readbyqxmd.com/read/29348667/neuroimmunology-brain-police
#1
Sian Lewis
No abstract text is available yet for this article.
January 19, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29318181/neuroimmunology-of-oms-and-anna-1-anti-hu-paraneoplastic-syndromes-in-a-child-with-neuroblastoma
#2
Michael R Pranzatelli, Nathan R McGee
No abstract text is available yet for this article.
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29307298/an-introduction-to-the-microbiome-and-ms
#3
Sebastien Trott, Irah L King
The human microbiota is composed of diverse forms of microorganisms that live on or in us and plays a crucial role in the health and development. Commensal species that reside in the intestine particularly influence host physiology at local and systemic levels. Multiple sclerosis (MS) is a debilitating autoimmune disorder of the central nervous system for which there is currently no cure. While the cause of MS is unknown, there is a growing body of evidence suggesting that the microbiota can play both pathogenic and protective roles in disease progression...
January 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29304719/neuroimmunology-of-traumatic-brain-injury-a-longitudinal-study-of-interdependency-of-inflammatory-markers-and-heart-rate-variability-in-severe-traumatic-brain-injury
#4
Akhil Deepika, Bhagavatula Indira Devi, Dhaval P Shukla, Talakad N Sathyaprabla, Rita Christopher, Shruthi S Ramesh
The purpose of the present study is to evaluate the inter-dependency between the electrophysiological (Heart rate variability) and inflammatory markers in traumatic brain injury (TBI) patients and the outcome in patients with severe TBI. A prospective exploratory study was done with a sample size of 89 severe traumatic brain injury patients. The Heart rate variability of these patients was recorded using a telemetric device BioHarness® (Zephyr technologies). The recordings were made on day 1 of the patients' admission into the ICU followed by serial recordings on Day 3 and day 10...
January 5, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29279610/neuroimmunology-in-2017-the-central-nervous-system-privileged-by-immune-connections
#5
Jonathan Kipnis, Anthony J Filiano
No abstract text is available yet for this article.
December 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29277216/neuroimmunology-2017-making-progress-over-20-years
#6
Adam Aj Al-Diwani, Belinda R Lennox
No abstract text is available yet for this article.
January 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29238090/neuroimmunology-a-painful-release
#7
Katherine Whalley
No abstract text is available yet for this article.
December 14, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29238017/-the-interface-between-the-immune-system-and-autonomic-nervous-system
#8
Shunya Nakane, Akihiro Mukaino, Yukio Ando
  The nervous system and the immune system are two major systems in human body. Although it was revealed these two systems correlated, the control of immune cell dynamics by the nervous system has come to draw a lot of attention at the present time. Recent advances in basic and preclinical science reveal that reflex neural circuits inhibit the production of cytokines and inflammation in several animal models. One well-characterized cytokine-inhibiting mechanism, termed the "inflammatory reflex", is dependent upon vagus nerve stimulation that inhibits cytokine production and attenuates the inflammation...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29199513/paraneoplastic-cerebellar-syndromes-associated-with-antibodies-against-purkinje-cells
#9
Philipp Schwenkenbecher, Lisa Chacko, Refik Pul, Kurt-Wolfram Sühs, Florian Wegner, Ulrich Wurster, Martin Stangel, Thomas Skripuletz
The paraneoplastic cerebellar syndrome presents as severe neuroimmunological disease associated with malignancies. Antibodies against antigens expressed by tumor cells cross-react with proteins of cerebellar Purkinje cells leading to neuroinflammation and neuronal loss. These antineuronal antibodies are preferentially investigated by serological analyses while examination of the cerebrospinal fluid is only performed infrequently. We retrospectively investigated twelve patients with antineuronal antibodies against Purkinje cells with a special focus on cerebrospinal fluid...
December 4, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29184885/sudden-infant-death-syndrome-infection-prone-sleep-position-and-vagal-neuroimmunology
#10
Paul Nathan Goldwater
Recent findings suggest that infection (and sepsis) stand alone as the only plausible mechanism of causation of sudden infant death syndrome (SIDS) and accordingly achieves congruence with all clinicopathological and epidemiological findings. This review examines the role of infection in the pathogenesis of SIDS in the context of the major risk factor of prone sleep position. The study explores how sleep position could interact with the immune system and inflammatory response via vagal neural connections, which could play key roles in gut and immune homeostasis...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29157501/evaluation-and-management-of-autoimmune-encephalitis-a-clinical-overview-for-the-practicing-child-psychiatrist
#11
REVIEW
GenaLynne C Mooneyham, William Gallentine, Heather Van Mater
Medical conditions that present with psychiatric symptoms are becoming increasingly well-recognized in response to the emergence of the field of neuroimmunology. As the availability of testing for novel antineuronal antibodies has increased, so too has the clinical awareness of this diagnostic spectrum. Psychiatrists may have little exposure to this area of expertise, yet may be called on to assist in the diagnosis and treatment of patients with complex neuropsychiatric syndromes secondary to autoimmune encephalitis...
January 2018: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/29125422/characteristics-of-morphologic-macular-abnormalities-in-neuroimmunology-practice
#12
Omar Al-Louzi, Elias S Sotirchos, Angela Vidal-Jordana, Shin C Beh, Julia Button, Howard S Ying, Laura J Balcer, Elliot M Frohman, Shiv Saidha, Peter A Calabresi, Scott D Newsome
BACKGROUND: Morphologic macular abnormalities (MMAs) are frequently seen on macular optical coherence tomography (OCT) imaging in neuroimmunology practice, yet studies pragmatically assessing prevalence and risk factors of MMAs to date are limited. OBJECTIVE: To describe the characteristics of MMAs in a neuroimmunology-based academic practice. METHODS: Cross-sectional study of 1450 patients (2900 eyes) who underwent spectral-domain macular OCT between June 2010 and June 2012...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29123374/anti-cd20-cell-therapies-in-multiple-sclerosis-a-fixed-dosing-schedule-for-ocrelizumab-is-overkill
#13
Jagannadha Avasarala
Anti-CD 20 therapies have found significant uses in multiple sclerosis (MS). Based singularly on the accumulated evidence with the use of rituximab (RTX; Rituxan, Genentech, and Biogen) in neuroimmunological diseases, ocrelizumab (OCR; Ocrevus, Genentech) was developed as a treatment option for MS and selectively targets CD20 B cells, a cell surface antigen found on pre-B cells, mature, and memory B cells, but not on lymphoid stem cells and plasma cells. On the basis of indirect evidence, elimination of the antigen-presenting capabilities and antigen nonspecific immune functions of B cells appear to be central to the therapeutic efficacy of anti-CD20 B-cell therapies...
2017: Drug Target Insights
https://www.readbyqxmd.com/read/29103430/promise-progress-and-pitfalls-in-the-search-for-central-nervous-system-biomarkers-in-neuroimmunological-diseases-a-role-for-cerebrospinal-fluid-immunophenotyping
#14
Bibiana Bielekova, Michael R Pranzatelli
Biomarkers are central to the translational medicine strategic focus, though strict criteria need to be applied to their designation and utility. They are one of the most promising areas of medical research, but the "biomarker life-cycle" must be understood to avoid false-positive and false-negative results. Molecular biomarkers will revolutionize the treatment of neurological diseases, but the rate of progress depends on a bold, visionary stance by neurologists, as well as scientists, biotech and pharmaceutical industries, funding agencies, and regulators...
August 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29103429/immunotherapeutics-in-pediatric-autoimmune-central-nervous-system-disease-agents-and-mechanisms
#15
Margherita Nosadini, Stefano Sartori, Suvasini Sharma, Russell C Dale
Beyond the major advances produced by careful clinical-radiological phenotyping and biomarker development in autoimmune central nervous system disorders, a comprehensive knowledge of the range of available immune therapies and a deeper understanding of their action should benefit therapeutic decision-making. This review discusses the agents used in neuroimmunology and their mechanisms of action. First-line treatments typically include corticosteroids, intravenous immunoglobulin, and plasmapheresis, while for severe disease second-line "induction" agents such as rituximab or cyclophosphamide are used...
August 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29103425/cancer-and-autoimmunity-paraneoplastic-neurological-disorders-associated-with-neuroblastic-tumors
#16
Wendy G Mitchell, Franz Blaes
Cancer and autoimmunity come together in paraneoplastic syndromes (PNS), which reflect the remote, not direct, effects of cancer. In the pediatric population, a variety of PNS have been described, but the most common of these rare disorders are instigated by neuroblastic tumors, such as neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. The main pediatric-onset neurological PNS are ROHHAD syndrome, anti-ANNA1 (anti-Hu), and opsoclonus-myoclonus syndrome. They manifest distinctive neurological features, which aid the diagnosis, though under-recognition still poses serious challenges and risks...
August 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29101600/normal-diet-vs-high-fat-diet-a-comparative-study-behavioral-and-neuroimmunological-changes-in-adolescent-male-mice
#17
Huali Wu, Qiongzhen Liu, Praveen Kumar Kalavagunta, Qiaoling Huang, Wenting Lv, Xiaohong An, Haijuan Chen, Tao Wang, Rakotomalala Manda Heriniaina, Tong Qiao, Jing Shang
Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states. Nevertheless the link between obesity and emotional disorders still remains to be elucidated. This issue is of particular interest during adolescence, which is important period for shaping learning/memory and mood regulation that can be sensitive to the detrimental effects of HFD. Our present study is focused to investigate behavioral and metabolic influences of short-term HFD intake in adolescent C57BL/6 mice...
November 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29081518/neuroimmunological-disorders-jak-in-the-itch
#18
Yvonne Bordon
No abstract text is available yet for this article.
October 30, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29054968/pivotal-neuroinflammatory-and-therapeutic-role-of-high-mobility-group-box-1-in-ischemic-stroke
#19
Seidu A Richard, Marian Sackey, Zhaoliang Su, Huaxi Xu
Stroke is a major cause of mortality and disability worldwide. Stroke is a frequent and severe neurovascular disorder. The main cause of stroke is atherosclerosis, and the most common risk factor for atherosclerosis is hypertension. Therefore, prevention and treatment of stroke are crucial issues in humans. High mobility group box 1 (HMGB1) is non-histone nuclear protein that is currently one of the crucial pro-inflammatory alarmin in ischemic stroke (IS). It is instantly released from necrotic cells in the ischemic core and activates an early inflammatory response...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29054292/addiction-a-dysregulation-of-satiety-and-inflammatory-processes
#20
Rivona Harricharan, Oualid Abboussi, William M U Daniels
Over the years, drug addiction has proven to be a perplexing conundrum for scientists. In attempts to decipher the components of the puzzle, multiple theories of addiction have been proposed. While these theories have assisted in providing essential fundamental information, current research recommends that a new theory needs to be presented taking into consideration the results of recent developments in the fields of neuroimmunology, genetics, and neuropsychiatry. After extensively examining the published literature, we propose in this review that neuroinflammation and hypothalamic functioning strongly underpin addictive behavior...
2017: Progress in Brain Research
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