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Neuroimmunology

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https://www.readbyqxmd.com/read/28638119/neuroimmunology-and-neuroepigenetics-in-the-establishment-of-sex-differences-in-the-brain
#1
REVIEW
Margaret M McCarthy, Bridget M Nugent, Kathryn M Lenz
The study of sex differences in the brain is a topic of neuroscientific study that has broad reaching implications for culture, society and biomedical science. Recent research in rodent models has led to dramatic shifts in our views of the mechanisms underlying the sexual differentiation of the brain. These include the surprising discoveries of a role for immune cells and inflammatory mediators in brain masculinization and a role for epigenetic suppression in brain feminization. How and to what degree these findings will translate to human brain development will be questions of central importance in future research in this field...
June 22, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28638039/-headache-immunology
#2
A V Prishchepa, A B Danilov
The overview is dedicated to the neuroimmunological mechanisms of headache development and chronification. Based on the analyzed data, the authors determined the relationship between immunological parameters and duration, intensity and other characteristics of this disease. These findings confirm that immunocompetent cells can be used as headache biomarkers and predictors of treatment efficacy. Questions about the role of separate parts of the immune system in the development and maintenance of a headache require further research...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28637489/synaptoimmunology-roles-in-health-and-disease
#3
REVIEW
Robert Nisticò, Eric Salter, Celine Nicolas, Marco Feligioni, Dalila Mango, Zuner A Bortolotto, Pierre Gressens, Graham L Collingridge, Stephane Peineau
Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in normal and pathological situations. In addition, novel immunological functions are emerging for proteins typically expressed at synapses. Under normal conditions, release of inflammatory mediators generally represents an adaptive and regulated response of the brain to immune signals. On the other hand, when immune challenge becomes prolonged and/or uncontrolled, the consequent inflammatory response leads to maladaptive synaptic plasticity and brain disorders...
June 20, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28632692/improved-123i-ioflupane-binding-after-immunotherapy-in-anti-nae-antibody-positive-hashimoto-encephalopathy-that-clinically-mimicked-multiple-system-atrophy
#4
Juuri Otsuka, Ayumi Hida, Kamiyu Ogyu, Ryogo Minamimoto, Sousuke Takeuchi
We describe an 84-year-old man with anti-NH2-terminal of α-enolase antibody-positive Hashimoto encephalopathy that clinically mimicked multiple system atrophy who underwent investigation by dopamine transporter SPECT before and after immunotherapy. Before treatment, dopamine transporter SPECT showed reduced striatal I-ioflupane binding, with a mean specific binding ratio of 2.42, even though he had no apparent parkinsonism. After immunotherapy, mean specific binding ratio was improved to 3.22. Dopamine transporter SPECT was useful in this case to detect subclinical striatal dysfunction, and evaluation both before and after immunotherapy helped to distinguish between neurodegenerative disease and neuroimmunological disorder...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28621767/neuroimmunology-complement-is-no-bystander-in-cns-degeneration
#5
Ian Fyfe
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28621764/neuroimmunology-b-cells-and-variant-baff-in-autoimmune-disease
#6
Manuel Comabella
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28615541/self-reported-occupational-noise-may-be-associated-with-prevalent-chronic-obstructive-pulmonary-disease-in-the-us-general-population
#7
Angel M Dzhambov, Donka D Dimitrova
INTRODUCTION: Occupational noise exposure and chronic obstructive pulmonary disease (COPD) are common in the United States, but so far their association has not been explored. Given the neuroimmunological effects of noise, such an association seems plausible. Thus, the present study aimed to explore the association of occupational noise exposure with prevalent COPD in the US general population. MATERIALS AND METHODS: We used data from the population-based National Health Interview Survey (NHIS) 2014...
May 2017: Noise & Health
https://www.readbyqxmd.com/read/28603460/cultivating-the-multiple-sclerosis-workforce-of-the-future
#8
Gabriele C DeLuca, Guy Buckle, Irene Cortese, Jennifer S Graves, June Halper, Scott D Newsome, Nancy Sicotte, Corey C Ford
Multiple sclerosis (MS) is a complex neurologic disorder that affects people with ever-changing needs. The MS health-care field has entered an era of exponential knowledge growth in which better understanding of the immunologic dysregulation of the disease has translated into an expanding array of treatment options. It is estimated that, if it has not already, within the next decade the demands of a growing MS patient population will outstrip the number of professionals dedicated to the management of this chronic, lifelong disease...
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28588765/evidence-of-disease-control-a-realistic-concept-beyond-neda-in-the-treatment-of-multiple-sclerosis
#9
Ana C Londoño, Carlos A Mora
Although no evidence of disease activity (NEDA) permits evaluation of response to treatment in the systematic follow-up of patients with multiple sclerosis (MS), its ability to accomplish detection of surreptitious activity of disease is limited, thus being unable to prevent patients from falling into a non-reversible progressive phase of disease. A protocol of evaluation based on the use of validated biomarkers that is conducted at an early stage of disease would permit the capture of abnormal neuroimmunological phenomena and lead towards intervention with modifying therapy before tissue damage has been reached...
2017: F1000Research
https://www.readbyqxmd.com/read/28555833/predictive-models-in-the-diagnosis-and-treatment-of-autoimmune-epilepsy
#10
Divyanshu Dubey, Jaysingh Singh, Jeffrey W Britton, Sean J Pittock, Eoin P Flanagan, Vanda A Lennon, Jan-Mendelt Tillema, Elaine Wirrell, Cheolsu Shin, Elson So, Gregory D Cascino, Dean M Wingerchuk, Matthew T Hoerth, Jerry J Shih, Katherine C Nickels, Andrew McKeon
OBJECTIVE: To validate predictive models for neural antibody positivity and immunotherapy response in epilepsy. METHODS: We conducted a retrospective study of epilepsy cases at Mayo Clinic (Rochester-MN; Scottsdale-AZ, and Jacksonville-FL) in whom autoimmune encephalopathy/epilepsy/dementia autoantibody testing profiles were requested (06/30/2014-06/30/2016). An Antibody Prevalence in Epilepsy (APE) score, based on clinical characteristics, was assigned to each patient...
May 26, 2017: Epilepsia
https://www.readbyqxmd.com/read/28555437/autoimmunity-in-2016
#11
REVIEW
Carlo Selmi
The number of peer-reviewed articles published during the 2016 solar year and retrieved using the "autoimmunity" key word remained stable while gaining a minimal edge among the immunology articles. Nonetheless, the quality of the publications has been rising significantly and, importantly, acquisitions have become available through scientific journals dedicated to immunology or autoimmunity. Major discoveries have been made in the fields of systemic lupus erythematosus, rheumatoid arthritis, autoimmunity of the central nervous system, vasculitis, and seronegative spondyloarthrithritides...
May 30, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28542592/fatigue-in-patients-with-neuromyelitis-optica-spectrum-disorder-and-its-impact-on-quality-of-life
#12
Jin Myoung Seok, Misong Choi, Eun Bin Cho, Hye Lim Lee, Byoung Joon Kim, Kwang Ho Lee, Pamela Song, Eun Yeon Joo, Ju-Hong Min
Fatigue is a prevalent symptom and major burden in neuroimmunological diseases. In neuromyelitis optica spectrum disorder (NMOSD), a severe autoimmune central nervous system (CNS) inflammatory disease with autoantibodies reactive to aquaporin-4, there are few reports about fatigue and quality of life (QOL). We aimed to evaluate the severity of fatigue and its relationship with QOL in patients with NMOSD. We prospectively studied patients with NMOSD who were in remission and seropositive for anti-aquaporin-4 antibody, and they were divided into 2 groups based on the presence of fatigue assessed using the Functional Assessment of Chronic Illness Therapy-fatigue score...
2017: PloS One
https://www.readbyqxmd.com/read/28529069/cholinergic-modulation-of-the-immune-system-presents-new-approaches-for-treating-inflammation
#13
REVIEW
Donald B Hoover
The nervous system and immune system have broad and overlapping distributions in the body, and interactions of these ubiquitous systems are central to the field of neuroimmunology. Over the past two decades, there has been explosive growth in our understanding of neuroanatomical, cellular, and molecular mechanisms that mediate central modulation of immune functions through the autonomic nervous system. A major catalyst for growth in this field was the discovery that vagal nerve stimulation (VNS) caused a prominent attenuation of the systemic inflammatory response evoked by endotoxin in experimental animals...
May 18, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28504258/neuroimmunology-macrophages-help-you-burn-energy
#14
Lucy Bird
No abstract text is available yet for this article.
June 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28475458/mda5-associated-neuroinflammation-and-the-singleton-merten-syndrome-two-faces-of-the-same-type-i-interferonopathy-spectrum
#15
Insa Buers, Gillian I Rice, Yanick J Crow, Frank Rutsch
In 1973, Singleton and Merten described a new syndrome in 2 female probands with aortic and cardiac valve calcifications, early loss of secondary dentition, and widened medullary cavities of the phalanges. In 1984, Aicardi and Goutières defined a phenotype resembling congenital viral infection with basal ganglia calcification and increased protein content in the cerebrospinal fluid. Between 2006 and 2012, mutations in 6 different genes were described to be associated with Aicardi-Goutières syndrome, specifically-TREX1, RNASEH2A, RNASEH2B, RNASEH2C, ADAR, and SAMHD1...
May 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28443641/neuroimmunology-immune-signals-packaged-in-the-brain
#16
Lucy Bird
No abstract text is available yet for this article.
May 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28439527/precision-in-neuroimmunology
#17
EDITORIAL
Josep Dalmau
No abstract text is available yet for this article.
May 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28421534/immune-alterations-in-cd8-t-cells-are-associated-with-neuronal-c-c-and-c-x-c-chemokine-receptor-regulation-through-adenosine-a2a-receptor-signaling-in-a-btbr-t-itpr3-tf-j-autistic-mouse-model
#18
Sheikh F Ahmad, Mushtaq A Ansari, Ahmed Nadeem, Saleh A Bakheet, Raish Mohammad, Sabry M Attia
Associative studies on a range of neurodevelopmental disorders have identified relationships between behavioral deficits and immune system function. The BTBR T(+) Itpr3(tf)/J (BTBR) mouse strain displays aberrant characteristics in its social behavior and immune responses, providing a significant opportunity to examine the relationship between behavior and the immune system. This study investigated the influence of adenosine A2A receptor activity on C-C and C-X-C chemokine receptors involved in autism in the BTBR mouse model...
April 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28359764/neuroimmunological-response-in-neuro-beh%C3%A3-et-s
#19
Alexis Alejandro Garcia-Rivero, Javier Gonzalez-Argote, José Pedro Martínez Larrarte, Ivonne Margarita Iglesias González, Alberto Juan Dorta-Contreras
Behçet's disease is a chronic, multisystem, autoimmune vasculitis characterized by a triad of key signs. We report the case of a 16-year-old Caucasian girl, who complained of headache, dizziness and paresis of the left side of her body. After physical examination and ancillary tests, she was diagnosed with Behçet's disease with neurological manifestations (neuro-Behçet's disease). She had a good response to treatment. IgG, IgA, IgM and albumin were quantified in serum and cerebrospinal fluid by single radial immunodiffusion...
March 27, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28288328/case-control-exploratory-study-of-cerebrospinal-fluid-chemokines-cytokines-and-lymphocyte-subsets-in-childhood-tourette-syndrome-with-positive-streptococcal-markers
#20
Michael R Pranzatelli, Elizabeth D Tate, Tyler J Allison
A longstanding question is whether neuroinflammation is present in children symptomatic for Tourette syndrome (TS) with positive streptococcal serology and throat cultures. The objective was to directly test for it using modern hypothesis-driven approaches. Profiling studies for 14 immune cell types (flow cytometry), 7 chemokines/cytokines (ELISA), oligoclonal bands, and other immunoglobulins were performed in this IRB-approved study of 5 children with TS and streptococcal markers compared to data from 26 non-inflammatory pediatric neurological controls...
March 10, 2017: Cytokine
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