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https://www.readbyqxmd.com/read/28220805/meta-analysis-of-metabolic-syndrome-and-prostate-cancer
#1
REVIEW
M Gacci, G I Russo, C De Nunzio, A Sebastianelli, M Salvi, L Vignozzi, A Tubaro, G Morgia, S Serni
BACKGROUND: Metabolic syndrome (MetS) and prostate cancer (PCa) are highly prevalent conditions worldwide. Current evidence suggests the emerging hypothesis that MetS could play a role in the development and progression of several neoplasms. The aims of this study are to evaluate the impact of MetS and MetS factors on PCa incidence, on the risk of high-grade PCa and to analyze the role of MetS and single MetS components on the development of aggressive PCa features. METHODS: A systematic literature search and analysis on PubMed, EMBASE, Cochrane and Academic One File databases until September 2015 was performed by 2 independent reviewers to evaluate the associations between MetS and PCa incidence, and between MetS and high-grade PCa incidence (bioptical Gleason Score⩾8, Prognostic Group 4-5 according to the novel prostate cancer grading system)...
February 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28177900/mcmda-matrix-completion-for-mirna-disease-association-prediction
#2
Jian-Qiang Li, Zhi-Hao Rong, Xing Chen, Gui-Ying Yan, Zhu-Hong You
Nowadays, researchers have realized that microRNAs (miRNAs) are playing a significant role in many important biological processes and they are closely connected with various complex human diseases. However, since there are too many possible miRNA-disease associations to analyze, it remains difficult to predict the potential miRNAs related to human diseases without a systematic and effective method. In this study, we developed a Matrix Completion for MiRNA-Disease Association prediction model (MCMDA) based on the known miRNA-disease associations in HMDD database...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28161070/metalloproteinase-11-potential-marker-and-molecular-target-in-advanced-and-castration-resistant-prostate-cancer-culture-study-of-peritumoral-fibroblasts
#3
J M Fernandez-Gomez, N Eiro, J J García-Rodríguez, A Quintás-Blanco, C Gonzalez-Ruiz de León, M L Perez de Haro, F Vizoso-Piñero
OBJECTIVE: To analyze the expression of metalloprotein 11 (MMP11) in cultured fibroblasts obtained from human prostate tumors with different clinical and pathological characteristics. MATERIAL AND METHODS: For this study we analyzed samples of transrectal prostate biopsies from tumors with different characteristics, treated with or whithout androgen deprivation (AD). After optimization of the culture method, fibroblasts were isolated and cultured to perform the study (PCR) of MMP11 mRNA...
February 1, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28100995/a-rare-case-of-intraductal-papillary-mucinous-neoplasm-of-the-biliary-duct-in-a-patient-with-prostate-adenocarcinoma
#4
Ravish Parekh, Gregory Krol, Cyrus Piraka, Surinder Batra
Intraductal papillary mucinous neoplasms (IPMNs) are mucin-producing papillary neoplasms of the pancreatic or biliary ductal system that exhibit variable cellular atypia and cause ductal dilation. There are few reported cases of IPMN arising from the biliary tree in the literature. It has a higher propensity to undergo malignant transformation compared to IPMN arising from the pancreatic duct. An 80-year-old male underwent cross-sectional tomography (CT) imaging of the abdomen for evaluation of prostate adenocarcinoma, which revealed an incidental 2...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28077171/prostate-specific-il-6-transgene-autonomously-induce-prostate-neoplasm-through-amplifying-inflammation-in-the-prostate-and-peri-prostatic-adipose-tissue
#5
Gang Liu, Jinyu Zhang, Lewis Frey, Xiao Gang, Kongming Wu, Qian Liu, Michael Lilly, Jennifer Wu
BACKGROUND: The causative role of the pro-inflammatory cytokine IL-6 in prostate cancer progression has been well established at molecular level. However, whether and how IL-6 may play a role in prostate cancer risk and development is not well defined. One limitation factor to acquiring this knowledge is the lack of appropriate animal models. METHODS: We generated a novel line of prostate-specific IL-6 transgenic mouse model. We compared the prostate pathology, tumorigenic signaling components, and prostate tumor microenvironment of the IL-6 transgenic mice with wild type littermates...
January 11, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28072703/screening-the-key-micrornas-and-transcription-factors-in-prostate-cancer-based-on-microrna-functional-synergistic-relationships
#6
Fan Feng, Jitao Wu, Zhenli Gao, Shengqiang Yu, Yuanshan Cui
Prostate cancer (PC) is a common neoplasm, and metastatic PC remains incurable. The study aims to screen key microRNAs (miRNAs) and transcription factors (TFs) involved in PC.The miRNA expression profile dataset (GSE45604) was downloaded from Gene Expression Omnibus database, including 50 PC and 10 normal specimens. Differentially expressed miRNAs (DEmiRNAs) were identified through limma package in R, and DEmiRNA-DEmiRNA co-regulation network was constructed based on the number of co-regulated target genes...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28064545/androgen-receptor-activation-a-prospective-therapeutic-target-for-bladder-cancer
#7
Taichi Mizushima, Kathleen A Tirador, Hiroshi Miyamoto
Patients with non-muscle-invasive or muscle-invasive bladder cancer undergoing surgery and currently available conventional therapy remain having a high risk of tumor recurrence or progression, respectively. Novel targeted molecular therapy is therefore expected to improve patient outcomes. Meanwhile, substantially higher incidence of bladder cancer in men has prompted research on androgen-mediated androgen receptor (AR) signaling in this malignancy. Indeed, preclinical evidence has suggested that AR signaling plays an important role in urothelial carcinogenesis and tumor outgrowth as well as resistance to some of the currently available conventional non-surgical therapies...
January 19, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28058701/correlation-between-chromosome-9p21-locus-deletion-and-prognosis-in-clinically-localized-prostate-cancer
#8
Érika Aparecida Felix de Barros, José Pontes-Junior, Sabrina Thalita Reis, Amanda Eunice Ramos Lima, Isida C Souza, Jose Lucas Salgueiro, Douglas Fontes, Humberto Dellê, Rafael Ferreira Coelho, Nayara Izabel Viana, Kátia Ramos Moreira Leite, William C Nahas, Miguel Srougi
BACKGROUND: Some studies have reported that deletions at chromosome arm 9p occur frequently and represent a critical step in carcinogenesis of some neoplasms. Our aim was to evaluate the deletion of locus 9p21 and chromosomes 3, 7 and 17 in localized prostate cancer (PC) and correlate these alterations with prognostic factors and biochemical recurrence after surgery. METHODS: We retrospectively evaluated surgical specimens from 111 patients with localized PC who underwent radical prostatectomy...
January 5, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28034818/clivus-metastasis-of-a-duodenal-adenocarcinoma-a-case-report-and-literature-review
#9
REVIEW
Simone E Dekker, Jay Wasman, Kevin K Yoo, Fernando Alonso, Robert W Tarr, Nicholas C Bambakidis, Kenneth Rodriguez
BACKGROUND: Clival metastases of adenocarcinomas are exceptionally rare tumors, especially when they arise from the small intestine. To our knowledge, here we present first report of a metastasis of a duodenal adenocarcinoma to the clivus. We also present a systematic review detailing metastasis to the clivus. METHODS: Studies were identified using the search terms clivus metastasis, skull base metastasis, and clivus in PubMed. We collected the following information: histopathology of the primary tumor, symptoms, history, treatment, and follow up...
December 26, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28029646/the-role-of-prostate-tumor-overexpressed-1-in-cancer-progression
#10
REVIEW
Verónica Cánovas, Matilde Lleonart, Juan Morote, Rosanna Paciucci
Prostate-Tumor-Overexpressed-1 (PTOV1) is a conserved adaptor protein discovered as overexpressed in prostate cancer. Since its discovery, the number of binding partners and associated cellular functions has increased and helped to identify PTOV1 as regulator of gene expression at transcription and translation levels. Its overexpression is associated with increased tumor grade and proliferation in prostate cancer and other neoplasms, including breast, ovarian, nasopharyngeal, squamous laryngeal, hepatocellular and urothelial carcinomas...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28001329/fna-biopsy-of-secondary-nonlymphomatous-malignancies-in-salivary-glands-a-multi-institutional-study-of-184-cases
#11
He Wang, Raza S Hoda, William Faquin, Esther Diana Rossi, Nihar Hotchandani, Tianlin Sun, Marc Pusztaszeri, Tommaso Bizzarro, Massimo Bongiovanni, Viren Patel, Nirag Jhala, Guido Fadda, Yun Gong
BACKGROUND: Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve the salivary glands. Fine-needle aspiration biopsy (FNAB) of SMSG can present diagnostic challenges. The current report presents the largest such FNAB series to date. METHODS: A search of the pathology database from 6 academic institutions identified 184 FNAB cases of nonlymphomatous SMSG. RESULTS: Of the 184 cases, 171 were of the parotid glands, and 13 were of the submandibular glands; 130 patients were men, and 54 were women, and the mean patient age at diagnosis was 68 years...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27997422/psma-expression-in-tumor-neovasculature-endothelial-cells-of-follicular-thyroid-adenoma-as-identified-by-molecular-imaging-using-68ga-psma-ligand-pet-ct
#12
Thorsten Derlin, Hans-Heinrich Kreipe, Udo Schumacher, Bisharah Soudah
The prostate-specific membrane antigen (PSMA) is expressed by both prostate cancer and other neoplasms. We report the case of a 65-year-old man with castration-resistant metastatic prostate cancer who underwent Ga-PSMA ligand PET/CT for restaging of disease. Ga-PSMA ligand accumulation was noted in a thyroid lesion, suspicious for thyroid malignancy on complementary ultrasound. Subsequent resection and histopathological analysis showed follicular thyroid adenoma with PSMA expression in tumor neovasculature endothelial cells, but not in thyroid epithelial cells...
March 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27933279/is-there-a-role-for-genetic-information-in-risk-assessment-and-decision-making-in-prostate-cancer
#13
Mohamadreza Nowroozi, Mohsen Ayati, Erfan Amini, Reza Mahdian, Behzad Yousefi, Amir Arbab, Mansour Jamali Zawarei, Hasan Niroomand, Hamidreza Ghorbani, Alireza Ghadian
OBJECTIVES: Prostate cancer is a neoplasm with a variable natural history and clinical behavior. There is much debate on the use of inherited genetic information in clinical application including risk assessment and treatment decisions. This study was performed to evaluate the relationship between clinical parameters of prostate cancer (PSA, Gleason score, and metastasis) and expression of NKX3.1, AMACR, TMPRSS2-ERG, ERG, and SPINK1 genes. METHODS: Newly diagnosed cases of prostate cancer were selected for this study...
November 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27906859/recent-advances-in-nuclear-medicine-in-endocrine-oncology
#14
Markus Luster, Andreas Pfestroff, Frederik A Verburg
PURPOSE OF REVIEW: The purpose is to review recent advances concerning the role of nuclear medicine in endocrine oncology. RECENT FINDINGS: For I therapy of thyroid cancer a thyrotropin (TSH) more than 30 mU/l has for many years been deemed a condition sine qua non. However, new data show that patients with lower TSH levels at the time of ablation have the same rate of successful ablation as those with TSH more than 30 mU/l.I-124 combined integrated positron emission tomography and computed X-ray tomography was shown to be highly accurate in predicting findings on posttherapy radioiodine scanning and was shown to have a high prognostic power...
January 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27888866/hereditary-forms-of-colorectal-cancer
#15
Antoni Castells
Colorectal cancer is one of the most frequent neoplasms in western countries; it is the third most common cancer in men after prostate and lung cancer and the second most common in women after breast cancer. Colorectal cancer is usually sporadic but in a small proportion is hereditary. The genetic cause is well established, allowing pre-symptomatic diagnosis in at-risk relatives. The present article reviews the most novel findings presented at the latest meeting of the American Gastroenterological Association on hereditary forms of colorectal cancer, especially Lynch syndrome and MUTYH-associated polyposis, as well as diverse organisational aspects that can favour the correct management of these patients and their relatives...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27861390/diagnosis-and-treatment-of-gastrointestinal-stromal-tumor-extending-to-prostate-a-case-report-and-literature-review
#16
Huan Xu, Chong Liu, Yanbo Chen, Meng Gu, Zhikang Cai, Qi Chen, Zhong Wang
RATIONALE: Gastrointestinal stromal tumor (GIST) is the neoplasm of gastrointestinal tract. PATIENT CONCERNS: The patient complained about the retention of urinary. DIAGNOSES: GIST. INTERVENTIONS: radical prostatectomy and the imatinib therapy. OUTCOMES: No recurrence and metastasis have been found during a 14-month follow-up. LESSONS: comprehensive treatment is necessary for the GIST treatment...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27844337/physical-activity-and-prostate-cancer-an-updated-review
#17
REVIEW
Roy J Shephard
Prostate cancer affects a major proportion of older men, and effective preventive measures are few. Earlier suggestions of 10-30% risk reduction from vigorous physical activity thus merit further analysis. This narrative review updates information on associations between physical activity and prostate cancer, seeking activity patterns associated with maximal risk reduction. Systematic searches of Ovid/MEDLINE and PubMed databases from 1996 to June 2016 have linked the terms prostate neoplasms/prostate cancer with occupation, occupational title, sedentary job or heavy work, exercise, physical activity, sports, athletes, physical education/training or aerobic fitness...
November 14, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27844130/-second-neoplasms-after-percutaneous-radiotherapy
#18
F Haidl, D Pfister, R Semrau, A Heidenreich
Radiation therapy represents an alternative treatment to radical prostatectomy in the management of clinically localized prostate cancer. Radiation-induced second neoplasms are defined by a latency period of at least 5 years, location within the field of radiation therapy, and a histology which differs from the primary tumor. Based on the data in the literature, there is a consistently increased risk of bladder cancer (HR: 1.67, 95% CI 1.55-1.80), rectal cancer (HR: 1.79, 95% CI 1.34-2.38), and colorectal cancer (HR: 1...
November 14, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27804940/-estimation-of-the-diagnostic-potential-of-apod-ptov1-and-epha4-for-prostatic-neoplasms
#19
D O Allina, Yu Yu Andreeva, L E Zavalishina, L V Moskvina, G A Frank
: Prostate cancer is one of the most frequently detected malignancies in men. The gold standard for its diagnosis is morphological examination; at the same time the differential diagnosis of adenocarcinoma, high-grade prostatic intraepithelial neoplasia (HGPIN), and benign conditions that are able to mimic the malignancies is tremendously difficult in a number of cases, this being so, the hyperdiagnosis rate of HGPIN requiring mandatory repeat biopsy is as high as 24%. The currently available differential diagnostic panel of antibodies is imperfect, which necessitates a search for novel markers...
2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/27792139/lack-of-tert-promoter-mutations-in-human-b-cell-non-hodgkin-lymphoma
#20
Gary Lam, Rena R Xian, Yingying Li, Kathleen H Burns, Karen L Beemon
Non-Hodgkin lymphomas (NHL) are a heterogeneous group of immune cell neoplasms that comprise molecularly distinct lymphoma subtypes. Recent work has identified high frequency promoter point mutations in the telomerase reverse transcriptase (TERT) gene of different cancer types, including melanoma, glioma, liver and bladder cancer. TERT promoter mutations appear to correlate with increased TERT expression and telomerase activity in these cancers. In contrast, breast, pancreatic, and prostate cancer rarely demonstrate mutations in this region of the gene...
October 25, 2016: Genes
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