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https://www.readbyqxmd.com/read/28101643/polymorphisms-in-genes-encoding-mir-155-and-mir-146a-are-associated-with-protection-to-type-1-diabetes-mellitus
#1
Taís S Assmann, Guilherme C K Duarte, Letícia A Brondani, Pedro H O de Freitas, Égina M Martins, Luís H Canani, Daisy Crispim
AIMS: Type 1 diabetes mellitus (T1DM) is characterized by severe autoimmune destruction of pancreatic beta-cells. The triggering of autoimmunity against beta-cells is probably caused by a combination of environmental and genetic risk factors. Even though much is known about the genetic of T1DM, more information is needed to completely unravel this tangled disease. MicroRNAs (miRNAs) are a class of small noncoding RNAs molecules that negatively regulate gene expression by inducing target mRNA cleavage or by inhibiting protein translation...
January 19, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28101175/effect-of-mir-146a-and-mir-155-on-cardiac-xenotransplantation
#2
Zhicheng Zhao, Feng Qi, Tong Liu, Weihua Fu
The aim of the present study was to investigate the expression levels of miR-146a and miR-155 in a cardiac xenograft model treated with the immunosuppressant FK506, and to construct lentiviral vectors to further study the roles of miR-146a and miR-155 in cardiac xenotransplantation. Expression levels of miR-146a and miR-155 were examined by quantitative polymerase chain reaction analysis and protein expression of RelA, which is a member of the nuclear factor-κB family, was examined by western blot analysis...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28096489/induced-packaging-of-cellular-micrornas-into-hiv-1-virions-can-inhibit-infectivity
#3
Hal P Bogerd, Edward M Kennedy, Adam W Whisnant, Bryan R Cullen
: Analysis of the incorporation of cellular microRNAs (miRNAs) into highly purified HIV-1 virions revealed that this largely, but not entirely, mirrored the level of miRNA expression in the producer CD4(+) T cells. Specifically, of the 58 cellular miRNAs detected at significant levels in the producer cells, only 5 were found in virions at a level 2- to 4-fold higher than that predicted on the basis of random cytoplasmic sampling. Of note, these included two miRNAs, miR-155 and miR-92a, that were reported previously to at least weakly bind HIV-1 transcripts...
January 17, 2017: MBio
https://www.readbyqxmd.com/read/28092102/micrornas-potential-candidates-for-diagnosis-and-treatment-of-colorectal-cancer
#4
REVIEW
Abdullah Moridikia, Hamed Mirzaei, Amirhossein Sahebkar, Jafar Salimian
Colorectal cancer (CRC) is known as the third common cancer worldwide and an important public health problem in different populations. Several genetics and environmental risk factors are involved in the development and progression of CRC including chromosomal abnormalities, epigenetic alterations, and unhealthy lifestyle. Identification of risk factors and biomarkers could lead to a better understanding of molecular pathways involved in CRC pathogenesis. MicroRNAs (miRNAs) are important regulatory molecules which could affect a variety of cellular and molecular targets in CRC...
January 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28090274/the-role-of-m2000-as-an-anti-inflammatory-agent-in-toll-like-receptor-2-microrna-155-pathway
#5
Fatemeh Pourgholi, Mahsa Hajivalili, Rasoul Razavi, Shadi Esmaeili, Behzad Baradaran, Ali Akbar Movasaghpour, Sanam Sadreddini, Hamidreza Goodarzynejad, Abbas Mirshafiey, Mehdi Yousefi
BACKGROUND: M2000 is a newly designed and safe Non-Steroidal Anti-Inflammatory Drug (NSAID). The aim of this study was to assess the effects of M2000 on expression levels of Suppressor of Cytokine Signaling-1 (SOCS-1) and Src Homology-2 domain-containing inositol-5'-phosphatase 1 (SHIP1) proteins via Toll-Like Receptor (TLR) 2/microRNA-155 pathway. METHODS: HEK293 TLR2 cell line and Peripheral Blood Mononuclear Cells (PBMCs) were treated by different concentrations of M2000 in MTT assay...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28088407/far-off-and-close-up-dry-matter-intake-modulate-indicators-of-immunometabolic-adaptations-to-lactation-in-subcutaneous-adipose-tissue-of-pasture-based-transition-dairy-cows
#6
M Vailati-Riboni, G Farina, F Batistel, A Heiser, M D Mitchell, M A Crookenden, C G Walker, J K Kay, S Meier, J R Roche, J J Loor
The common practice of increasing dietary energy density during the close-up dry period (last ∼3 wk prepartum) has been recently associated with a higher incidence of metabolic disorders after calving. Despite these reports, over-feeding of metabolizable energy (ME) during the far-off, nonlactating period is a common management policy aimed at achieving optimum calving body condition score (BCS) in pasture-based systems, as cows are generally thinner than total mixed ration cows at the end of lactation. Our hypothesis was that both far-off and close-up overfeeding influence the peripartum adipose tissue changes associated with energy balance and inflammatory state...
January 11, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28087411/aspirin-prevents-tnf-%C3%AE-induced-endothelial-cell-dysfunction-by-regulating-the-nf-%C3%AE%C2%BAb-dependent-mir-155-enos-pathway-role-of-a-mir-155-enos-axis-in-preeclampsia
#7
Joohwan Kim, Kyu-Sun Lee, Ji-Hee Kim, Dong-Keon Lee, Minsik Park, Seunghwan Choi, Wonjin Park, Suji Kim, Yoon Kyoung Choi, Jong Yun Hwang, Jongseon Choe, Moo-Ho Won, Dooil Jeoung, Hansoo Lee, Sungwoo Ryoo, Kwon-Soo Ha, Young-Guen Kwon, Young-Myeong Kim
Preeclampsia is an inflammatory disease with endothelial cell dysfunction that occurs via decreased endothelial nitric oxide synthase/nitric oxide (eNOS/NO) activity. Aspirin reduces the incidence of hypertensive pregnancy complications. However, the underlying mechanism has not been clearly explained. Here, we found that tumor necrosis factor (TNF)-α, microRNA (miR)-155, and eNOS levels as well as endothelial redox phenotype were differentially regulated in preeclamptic patients, implying the involvement of TNF-α- and redox signal-mediated miR-155 biogenesis and eNOS downregulation in the pathogenesis of preeclampsia...
January 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28086811/study-of-the-microrna-expression-profile-of-foreskin-derived-mesenchymal-stromal-cells-following-inflammation-priming
#8
Hussein Fayyad-Kazan, Mohammad Fayyad-Kazan, Bassam Badran, Dominique Bron, Laurence Lagneaux, Mehdi Najar
BACKGROUND: Due to their self-renewal capacity, multi-lineage potential, and immunomodulatory properties, mesenchymal stromal cells (MSCs) are an attractive tool for different therapeutic strategies. Foreskin (FSK), considered as a biological waste material, has already been shown to be a valuable source of MSCs. Besides their typical fibroblast like morphology and International Society for cellular Therapy compliant phenotype, foreskin-MSCs (FSK-MSCs) are clonogenic, and highly proliferative cells with multi-lineage and strong immunomodulatory capacities...
January 13, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28077577/extracellular-microrna-signature-of-human-helper-t-cell-subsets-in-health-and-autoimmunity
#9
Anna Torri, Donatella Carpi, Elisabetta Bulgheroni, Maria-Cristina Crosti, Monica Moro, Paola Gruarin, Riccardo L Rossi, Grazisa Rossetti, Dolores Di Vizio, Mirjam Hoxha, Valentina Bollati, Cristina Gagliani, Carlo Tacchetti, Moira Paroni, Jens Geginat, Laura Corti, Luigia Venegoni, Emilio Berti, Massimiliano Pagani, Giuseppe Matarese, Sergio Abrignani, Paola de Candia
Upon TCR stimulation, CD4+ T lymphocytes release extracellular vesicles (EVs) containing microRNAs. However, no data are available on whether human CD4+ T cell subsets release EVs containing different pattern of microRNAs. The present work aimed at filling this gap by assessing the microRNA content in EVs released upon in vitro TCR stimulation of Th1, Th17 and T regulatory (Treg) cells. Our results indicate that EVs released by Treg cells are significantly different compared to those released by the other subsets...
January 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28076897/microrna-expression-shows-inflammatory-dysregulation-and-tumor-like-proliferative-responses-in-joints-of-patients-with-post-infectious-lyme-arthritis
#10
Robert B Lochhead, Klemen Strle, Nancy D Kim, Minna J Kohler, Sheila L Arvikar, John M Aversa, Allen C Steere
OBJECTIVE: Lyme arthritis (LA) is caused by infection with Borrelia burgdorferi and usually resolves following spirochetal killing with antibiotics. However, in some patients, arthritis persists after antibiotic therapy. To provide insights into underlying pathogenic processes associated with post-infectious LA, we analyzed differences in microRNA expression between LA patients with active infection compared with those with post-infectious LA. METHODS: MicroRNA expression was assayed in synovial fluid (SF) from LA patients before and after oral and IV antibiotic therapy, and from synovial tissue from post-infectious LA patients obtained months after antibiotic therapy...
January 11, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28074870/microrna-155-is-upregulated-in-ascites-in-patients-with-spontaneous-bacterial-peritonitis
#11
Philipp Lutz, Mohamed M Haimid, Alessandra Pohlmann, Jennifer Lehmann, Christian Jansen, Robert Schierwagen, Sabine Klein, Christian P Strassburg, Ulrich Spengler, Jonel Trebicka
MircoRNA's (miR) have been recognised as important modulators of gene expression and potential biomarkers. However, they have been rarely investigated in bio fluids apart from blood. We investigated the association of miR-125b and miR-155 with complications of cirrhosis. Ascites was prospectively collected from patients with cirrhosis undergoing paracentesis at our department. miR's were determined in the supernatant using qPCR and normalized by SV-40. Clinical parameters were assessed at paracentesis and during follow-up...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069815/identification-and-characterization-of-mirna-differentially-expressed-in-macrophages-exposed-to-porphyromonas-gingivalis-infection
#12
Olivier Huck, Jacob Al-Hashemi, Laetitia Poidevin, Olivier Poch, Jean-Luc Davideau, Henri Tenenbaum, Salomon Amar
MicroRNAs (miRNAs) are short, non-coding RNAs involved in the regulation of several processes associated with inflammatory diseases and infection. Bacterial infection modulates miRNA expression to subvert any innate immune response. In this study, we analyzed bacterial modulation of miRNAs in bone-marrow-derived macrophages (BMMs), in which activity was induced by infection with Porphyromonas gingivalis (Pg) through a microarray analysis. Several miRNA expressions were modulated 3 hours post infection (at a MOI of 25)...
January 9, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28066106/modulation-of-hippocampal-gene-expression-of-microrna-146a-microrna-155-nuclear-factor-kappa-b-inflammatory-signaling-by-troxerutin-in-healthy-and-diabetic-rats
#13
Raana Yavari, Reza Badalzadeh, Mohammad Reza Alipour, Seyed Mahmoud Tabatabaei
OBJECTIVES: Inflammation plays a critical role in the progression of diabetic complications such as neurological disorders. Previous reports have indicated the memory-improving effect of troxerutin, in rat hippocampus, but the underlying mechanisms are unclear. Hence, we have investigated the effect of troxerutin pretreatment on gene expressions of inflammation-related microRNAs (miRs), miR-146a and miR-155, and nuclear factor-kappa B (NF-κB) signaling pathway in the hippocampus of healthy and diabetic rats...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28061948/levels-of-microrna-mir-16-and-mir-155-are-altered-in-serum-of-patients-with-tuberculosis-and-associate-with-responses-to-therapy
#14
Vishal Wagh, Anant Urhekar, Deepak Modi
Identification of blood biomarkers that can be useful for predicting Mycobacterium tuberculosis (M.TB) infection, effect of therapy and Multi Drug Resistant (MDR) TB infected individuals is clinically useful for combating tuberculosis epidemic. In this study, we have evaluated the levels of selected miRNAs in serum of TB and MDR TB patients. In addition, we have studied their levels in serum of patients post-therapy. The levels of 4-miRNAs (miR-16, miR-29a, miR-125b and miR-155) were measured in 30 newly diagnosed TB patients, 19 Multi Drug Resistant (MDR) TB patients, 10 patients who completed TB therapy and were TB negative...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28055298/vitamin-d-limits-inflammation-linked-microrna-expression-in-adipocytes-in-vitro-and-in-vivo-a-new-mechanism-for-the-regulation-of-inflammation-by-vitamin-d
#15
Esma Karkeni, Lauriane Bonnet, Julie Marcotorchino, Franck Tourniaire, Julien Astier, Jianping Ye, Jean-François Landrier
Inflammation of adipose tissue is believed to be a contributing factor to many chronic diseases associated with obesity. Vitamin D (VD) is now known to limit this metabolic inflammation by decreasing inflammatory marker expression and leukocyte infiltration in adipose tissue. In this study, we investigated the impact of VD on microRNA (miR) expression in inflammatory conditions in human and mouse adipocytes, using high-throughput methodology (miRNA PCR arrays). Firstly, we identified three miRs (miR-146a, miR-150, and miR-155) positively regulated by TNFα in human adipocytes...
January 5, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28045967/induction-of-multiple-mir-200-182-members-in-the-brains-of-mice-are-associated-with-acute-herpes-simplex-virus-1-encephalitis
#16
Anna Majer, Kyle A Caligiuri, Kamilla K Gale, Yulian Niu, Clark S Phillipson, Timothy F Booth, Stephanie A Booth
Important roles of microRNAs (miRNAs) in regulating the host response during viral infection have begun to be defined. However, little is known about the functional roles of miRNAs within an in vivo acute viral encephalitis model. We therefore identified global changes in miRNA expression during acute herpes simplex virus type 1 (HSV-1) encephalitis (HSVE) in mice. We found that many of the highly upregulated miRNAs (miR-155, miR-146a and miR-15b) detected in HSV-1 infected brain tissue are known regulators of inflammation and innate immunity...
2017: PloS One
https://www.readbyqxmd.com/read/28043542/the-analysis-of-exosomal-micro-rnas-in-peripheral-blood-mononuclear-cell-derived-macrophages-after-infection-with-bacillus-calmette-gu%C3%A3-rin-by-rna-sequencing
#17
Esmaeil Mortaz, Shamila D Alipoor, Payam Tabarsi, Ian M Adcock, Johan Garssen, Ali Akbar Velayati
OBJECTIVE/BACKGROUND: Tuberculosis (TB) is a major global threat to human health, especially in low-income countries. The diagnosis of TB is challenging because of the limitations of specificity and sensitivity with the current diagnostics. Novel, selective biomarkers for TB would be of great practical value. Exosomes are bioactive vesicles with 30-100nm in diameter, which are secreted from almost all cell types and are found in virtually every human body fluid. Exosomes transport micro-RNAs (miRNAs), which are post-transcriptional regulators of gene expression, around the body and allow miRNAs to modulate biological pathways in target cells...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28039186/mir-10b-5p-is-a-novel-th17-regulator-present-in-th17-cells-from-ankylosing-spondylitis
#18
L Chen, M H Al-Mossawi, A Ridley, T Sekine, A Hammitzsch, J de Wit, D Simone, H Shi, F Penkava, M Kurowska-Stolarska, I Pulyakhina, J C Knight, T J Kim, P Bowness
OBJECTIVE: To determine the microRNA (miR) signature in ankylosing spondylitis (AS) T helper (Th)17 cells. METHODS: Interleukin (IL)-17A-producing CD4+ T cells from patients with AS and healthy controls were FACS-sorted for miR sequencing and qPCR validation. miR-10b function was determined by miR mimic expression followed by cytokine measurement, transcriptome analysis, qPCR and luciferase assays. RESULTS: AS Th17 cells exhibited a miR signature characterised by upregulation of miR-155-5p, miR-210-3p and miR-10b...
December 30, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28036291/assessing-the-clinical-value-of-micrornas-in-formalin-fixed-paraffin-embedded-liposarcoma-tissues-overexpressed-mir-155-is-an-indicator-of-poor-prognosis
#19
Nikolaos Kapodistrias, Konstantinos Mavridis, Anna Batistatou, Penelope Gogou, Vasilios Karavasilis, Ioannis Sainis, Evangelos Briasoulis, Andreas Scorilas
Liposarcoma (LPS) is a malignancy with extreme heterogeneity and thus optimization towards personalizing patient prognosis and treatment is essential. Here, we evaluated miR-155, miR-21, miR-143, miR-145 and miR-451 that are implicated in LPS, as novel FFPE tissue biomarkers.A total of 83 FFPE tissue specimens from primary LPS and lipomas (LPM) were analyzed. A proteinase K incubation-Trizol treatment coupled protocol was used for RNA isolation. After polyadenylation of total RNA and reverse transcription, expression analysis of 9 candidate reference and 5 target miRNAs was performed by qPCR...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28031239/micrornas-142-3p-mir-155-and-mir-203-are-deregulated-in-gastric-malt-lymphomas-compared-to-chronic-gastritis
#20
Concepción Fernández, Beatriz Bellosillo, Mariana Ferraro, Agustín Seoane, Blanca Sánchez-González, Silvia Pairet, Aina Pons, Luis Barranco, María Carmen Vela, Eva Gimeno, Lluís Colomo, Carles Besses, Alfons Navarro, Antonio Salar
BACKGROUND: Over the last years, our knowledge on pathogenesis of gastric MALT lymphoma has greatly improved, but its morphological diagnosis is still hampered by overlapping histological features with advanced chronic gastritis. MicroRNAs are deregulated in lymphomas, but their role and usefulness in gastric MALT lymphoma has not been extensively investigated. MATERIALS AND METHODS: We analyzed the expression of 384 miRNAs using TaqMan microRNA assay in a training series of 10 gastric MALT lymphomas, 3 chronic gastritis and 2 reactive lymph nodes...
2, 2017: Cancer Genomics & Proteomics
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