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Mir-155

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https://www.readbyqxmd.com/read/29774026/critical-role-of-alternative-m2-skewing-in-mir-155-deletion-mediated-protection-of-colitis
#1
Jintao Li, Ji Zhang, Hongxia Guo, Shimin Yang, Weiping Fan, Nan Ye, Zhiqiang Tian, Tiantian Yu, Guoping Ai, Zigang Shen, Haiyang He, Ping Yan, Hui Lin, Xue Luo, Hongli Li, Yuzhang Wu
Inflammatory bowel disease (IBD) is associated with dysregulation of both innate and adaptive immune response in the intestine. MicroRNA (miR)-155 is frequently expressed and functions in many immune cell types. Besides its function in adaptive immunity, miR-155 is a key regulator of the innate immune response in macrophages, dendritic cells, and even in epithelia cells. Although the roles of miR-155 within T and B lymphocytes in colitis have been reported, its function in innate immune cells has not been thoroughly examined...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29768229/cross-linking-gold-nanoparticles-aggregation-method-based-on-localised-surface-plasmon-resonance-for-quantitative-detection-of-mir-155
#2
Aghil Esmaeili-Bandboni, Seyed Mohammad Amini, Reza Faridi-Majidi, Jamshid Bagheri, Javad Mohammadnejad, Esmaeil Sadroddiny
MiR-155 plays a critical role in the formation of cancers and other diseases. In this study, the authors aimed to design and fabricate a biosensor based on cross-linking gold nanoparticles (AuNPs) aggregation for the detection and quantification of miR-155. Also, they intended to compare this method with SYBR Green real-time polymerase chain reaction (PCR). Primers for real-time PCR, and two thiolated capture probes for biosensor, complementary with miR-155, were designed. Citrate capped AuNPs (18.7 ± 3...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29768211/long-term-persistence-of-exhausted-cd8-t-cells-in-chronic-infection-is-regulated-by-microrna-155
#3
Erietta Stelekati, Zeyu Chen, Sasikanth Manne, Makoto Kurachi, Mohammed-Alkhatim Ali, Keith Lewy, Zhangying Cai, Kito Nzingha, Laura M McLane, Jennifer L Hope, Adam J Fike, Peter D Katsikis, E John Wherry
Persistent viral infections and tumors drive development of exhausted T (TEX ) cells. In these settings, TEX cells establish an important host-pathogen or host-tumor stalemate. However, TEX cells erode over time, leading to loss of pathogen or cancer containment. We identified microRNA (miR)-155 as a key regulator of sustained TEX cell responses during chronic lymphocytic choriomeningitis virus (LCMV) infection. Genetic deficiency of miR-155 ablated CD8 T cell responses during chronic infection. Conversely, enhanced miR-155 expression promoted expansion and long-term persistence of TEX cells...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29767259/silencing-of-mir%C3%A2-155-suppresses-inflammatory-responses-in-psoriasis-through-inflammasome-nlrp3-regulation
#4
Quan Luo, Jingxin Zeng, Wei Li, Ling Lin, Xin Zhou, Xin Tian, Weiyu Liu, Lidan Zhang, Xibao Zhang
Psoriasis is a dermatosis with the major clinical symptoms of scale, erythema and itching, and it has a long disease course. In addition, it is easily recurrent and refractory, greatly affecting the physical and mental health of patients. In the present study, it was hypothesized that the function of miR‑155 increases psoriasis‑induced inflammation and that its expression may be dependent on inflammasome activation. miR‑155 expression was examined by gene chip array and quantitative polymerase chain reaction analysis...
May 14, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29754238/construction-and-integration-of-a-synthetic-microrna-cluster-for-multiplex-rna-interference-in-mammalian-cells
#5
Tingting Wang, Zhen Xie
Basic biological research and biomedical applications often require studying the multiple interactions between genes or proteins while multiplex RNA interference (RNAi) technology is still challenging in mammalian cells. In mammalian genomes, the natural microRNA (miRNA) clusters, of which the miRNAs often share similar expression patterns and target diverse genes, would provide a potential multiplex RNAi scaffold. Based on the natural pri-miR-155 precursor, we have developed and characterized a multiplex RNAi method by engineering synthetic miRNA clusters, among which the maturation and function of individual miRNA precursors are independent of their positions in the cluster...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29752719/hbv-suppresses-zhx2-expression-to-promote-proliferation-of-hcc-through-mir-155-activation
#6
Xiaojia Song, Siyu Tan, Zhuanchang Wu, Leiqi Xu, Zehua Wang, Yong Xu, Tixiao Wang, Chengjiang Gao, Yaoqin Gong, Xiaohong Liang, Lifen Gao, Brett T Spear, Chunhong Ma
Initiation of hepatocellular carcinoma (HCC) by chronic hepatitis B virus (HBV) infection is a complex process that includes both oncogene activation and tumor suppressor inhibition. The HBV X (HBx) protein has an important and complex role in processes leading to HCC. We previously identified the mammalian Zinc fingers and homeoboxes 2 (ZHX2) gene as an HCC-associated tumor suppressor gene. In the present study, we investigated whether the oncogenic properties of HBV and, more specifically, HBx, involved ZHX2 silencing...
May 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29751003/special-at-rich-binding1-protein-satb1-in-malignant-t-cells
#7
Simon Fredholm, Andreas Willerslev-Olsen, Özcan Met, Linda Kubat, Maria Gluud, Sarah L Mathiasen, Christina Friese, Edda Blümel, David L Petersen, Tengpeng Hu, Claudia Nastasi, Lise M Lindahl, Terkild B Buus, Thorbjørn Krejsgaard, Mariusz A Wasik, Katharina L Kopp, Sergei B Koralov, Jenny L Persson, Charlotte M Bonefeld, Carsten Geisler, Anders Woetmann, Lars Iversen, Jurgen C Becker, Niels Odum
Deficient expression of Suppressor Special AT-rich Binding-1 (SATB1) hampers thymocyte development and results in inept T cell lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides (MF), the most frequent variant of cutaneous T cell lymphoma (CTCL). Here we report on a disease-stage-associated decrease of SATB1 expression and an inverse expression of STAT5 and SATB1 in situ. Importantly, STAT5 inhibited SATB1 expression through induction of miR-155. Decreased SATB1 expression triggered enhanced expression of IL-5 and IL-9 (but not IL-6 and IL-32) whereas increased SATB1 expression had the opposite effect indicating that the mir-155 target SATB1 is a repressor of IL-5 and IL-9 in malignant T cells...
May 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29739060/lower-expression-of-mir-10a-in-coronary-artery-disease-and-its-association-with-pro-anti-inflammatory-cytokines
#8
Nariman Moradi, Reza Fadaei, Reza Ahmadi, Elham Kazemian, Soudabeh Fallah
BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide. Atherosclerosis, the main underlying cause of CAD, is a progressive inflammatory disease. microRNAs play a substantial role in the inflammatory process and pathogenesis of atherosclerosis. miR-155, a widely studied microRNA, is associated with inflammation but there are conflicting data regarding expression of miR-155 in CAD. miR-10a is also one of the key regulators of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway which have not been evaluated in peripheral blood mononuclear cells (PBMCs) of CAD patients...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29725352/ethyl-acetate-fraction-from-hedyotis-diffusa-plus-scutellaria-barbata-exerts-anti-inflammatory-effects-by-regulating-mir-155-expression-and-jnk-signaling-pathway
#9
Yuan Xu, Xiao-Xia Chen, Yi-Xin Jiang, Dan-Dan Zhang
Hedyotis diffusa Willd and Scutellaria barbata D. Don (HDSB) were the core couplet in medicines that were commonly used for the purpose of anti-inflammation and anticancer treatments in China. However, biological properties of this couplet have not been fully elucidated. In this study, we screened fractions of HDSB for their anti-inflammatory activities and explored pertinent molecular mechanisms on murine macrophage RAW264.7 cell model. Ethyl acetate fraction from the aqueous extract of the couplet at equal weight ratio (EA11) showed the strongest inhibition of the nitrite accumulation in supernatant of RAW264...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29720426/microrna-155-modulates-acute-graft-versus-host-disease-by-impacting-t-cell-expansion-migration-and-effector-function
#10
Nina C Zitzer, Katiri Snyder, Xiamoei Meng, Patricia A Taylor, Yvonne A Efebera, Steven M Devine, Bruce R Blazar, Ramiro Garzon, Parvathi Ranganathan
MicroRNA-155 (miR-155) is a small noncoding RNA critical for the regulation of inflammation as well as innate and adaptive immune responses. MiR-155 has been shown to be dysregulated in both donor and recipient immune cells during acute graft-versus-host disease (aGVHD). We previously reported that miR-155 is upregulated in donor T cells of mice and humans with aGVHD and that mice receiving miR-155-deficient (miR155-/- ) splenocytes had markedly reduced aGVHD. However, molecular mechanisms by which miR-155 modulates T cell function in aGVHD have not been fully investigated...
May 2, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29715124/candidate-microrna-biomarkers-of-therapeutic-response-to-sunitinib-in-metastatic-renal-cell-carcinoma-a-validation-study-in-patients-with-extremely-good-and-poor-response
#11
Julia Kovacova, Jaroslav Juracek, Alexandr Poprach, Tomas Buchler, Jindrich Kopecky, Ondrej Fiala, Marek Svoboda, Ondrej Slaby
BACKGROUND/AIM: Targeted therapy with the tyrosine kinase inhibitor sunitinib is used in the first line of metastatic renal cell carcinoma (mRCC) treatment. The aim of the present study was independent validation of microRNAs (miRNAs) identified in previous studies as biomarkers predicting response to sunitinib therapy. MATERIALS AND METHODS: Based on a literature search, 10 miRNAs were chosen from six relevant studies as candidates for validation: miR-155, miR-484, miR-221, miR-222, miR-425, miR-133, miR-410, miR-141, miR-628 and miR-942...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29704472/visual-detection-of-mirna-using-peroxidase-like-catalytic-activity-of-dna-cuncs-and-methylene-blue-as-indicator
#12
Yasaman-Sadat Borghei, Morteza Hosseini, Mohammad Reza Ganjali
In this study, we developed a colorimetric method which is primarily based on the limited amount of redox in response to the miRNA target analyte binding for the determination of the miRNA, which is used as a biomarker to confirm the clinical diagnosis of cancers such as breast cancer. This method is on the basis of the peroxidase-like property of DNA templated copper nanoclusters (DNA-CuNCs). In this research, it was found that the DNA (poly T) stabilized green emitting CuNCs which exhibited enzyme-like peroxidase activity...
April 25, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29698509/microrna-425-and-microrna-155-cooperatively-regulate-atrial-natriuretic-peptide-expression-and-cgmp-production
#13
Sara Vandenwijngaert, Clara D Ledsky, Obiajulu Agha, Connie Wu, Dongjian Hu, Aranya Bagchi, Ibrahim J Domian, Emmanuel S Buys, Christopher Newton-Cheh, Donald B Bloch
AIMS: Atrial natriuretic peptide (ANP), secreted primarily by atrial cardiomyocytes, decreases blood pressure by raising cyclic 3',5'-guanosine monophosphate (cGMP) levels and inducing vasorelaxation, natriuresis, and diuresis. Raising the level of ANP has been shown to be an effective treatment for hypertension. To advance the future development of an anti-microRNA (miR) approach to increasing expression of ANP, we investigated the regulation of NPPA expression by two miRs: miR-425 and miR-155...
2018: PloS One
https://www.readbyqxmd.com/read/29694627/expression-of-mir-155-mir-146a-and-mir-326-in-t1d-patients-from-chile-relationship-with-autoimmunity-and-inflammatory-markers
#14
Diego F García-Díaz, Carolina Pizarro, Patricia Camacho-Guillén, Ethel Codner, Néstor Soto, Francisco Pérez-Bravo
Objective The aim of this research was to analyze the expression profile of miR-155, miR-146a, and miR-326 in peripheral blood mononuclear cells (PBMC) of 47 patients with type 1 diabetes mellitus (T1D) and 39 control subjects, as well as the possible association with autoimmune or inflammatory markers. Subjects and methods Expression profile of miRs by means of qPCR using TaqMan probes. Autoantibodies and inflammatory markers by ELISA. Statistical analysis using bivariate correlation. Results The analysis of the results shows an increase in the expression of miR-155 in T1D patients in basal conditions compared to the controls (p < 0...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29693176/pu-1-attenuates-tnf%C3%A2-%C3%AE-%C3%A2-induced-proliferation-and-cytokine-release-of-rheumatoid-arthritis-fibroblast%C3%A2-like-synoviocytes-by-regulating-mir%C3%A2-155-activity
#15
Zikang Xie, Yuxing Qu, Pengfei Shen, Bin Wang, Kang Wei, Bin Du
The present study aimed to determine the role of transcription factor PU.1 (PU.1) in tumor necrosis factor‑α (TNF‑α)‑induced proliferation and cytokine release of rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLS). It was determined that TNF‑α induced proliferation of RA‑FLS, whereas transfection with PU.1 3'untranslated region (UTR) inhibited this proliferation. Additionally, PU.1 3'UTR attenuated TNF‑α‑induced production of interleukin (IL)‑6 and IL‑1β, and downregulated the expression level of micro RNA (miR)‑155 in a dose‑dependent manner...
April 23, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29693141/analysis-of-nfkb2%C3%A2-mediated-regulation-of-mechanisms-underlying-the-development-of-hodgkin-s-lymphoma
#16
Yunping Zhang, Laigen Tong, Sisi Chen, Wenzhong Wu, Li Wang
Nuclear factor‑κB (NF‑κB) is widely involved in various lymphoid malignancies. However, its exact functional role and potential regulatory mechanisms in Hodgkin's lymphoma (HL) remains unclear. The present study aimed to investigate the regulatory mechanism of NF‑κB in HL by analysis of a gene expression profile that was obtained from HL cells with or without NF‑κB subunit 2 (NFKB2) knockdown. The GSE64234 dataset containing 6 HL cell line specimens transfected with small interfering (si)RNA against NFKB2 and 6 control specimens transfected with non‑targeting siRNA sequences was downloaded from the Gene Expression Omnibus database...
April 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29683112/a-panel-of-serum-noncoding-rnas-for-the-diagnosis-and-monitoring-of-response-to-therapy-in-patients-with-breast-cancer
#17
Sheng-Kai Huang, Qing Luo, Hua Peng, Jia Li, Mei Zhao, Jia Wang, Yu-Yu Gu, Yan Li, Peng Yuan, Guo-Hua Zhao, Chang-Zhi Huang
BACKGROUND The aim of this study was to identify a panel of serum noncoding RNAs (ncRNAs) as potential diagnostic and prognostic biomarkers for breast cancer. MATERIAL AND METHODS Patients with breast cancer (n=30), and normal controls (n=30) were included in the 'training set.' A 'validation set' included cases of breast cancer (n=128) and controls (n=77). All cases provided blood samples for serum analysis. All cases of breast cancer were confirmed histologically and were staged. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to detect the expression of 11 candidate ncRNAs, including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), in the serum...
April 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29679626/microrna-expression-profile-in-plasma-from-type-1-diabetic-patients-case-control-study-and-bioinformatic-analysis
#18
Taís S Assmann, Mariana Recamonde-Mendoza, Márcia Puñales, Balduíno Tschiedel, Luís H Canani, Daisy Crispim
AIMS: To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved. METHODS: Expressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan Low Density Arrays (Thermo Fisher Scientific). Five dysregulated miRNAs were then chosen for validation in an independent sample of 27 T1DM patients and 14 controls, using RT-qPCR...
April 19, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29676073/overexpression-of-mir-155-5p-inhibits-the-proliferation-and-migration-of-il-13-induced-human-bronchial-smooth-muscle-cells-by-suppressing-tgf-%C3%AE-activated-kinase-1-map3k7-binding-protein-2
#19
Yujia Shi, Xingli Fu, Qi Cao, Zhengdao Mao, Yi Chen, Yun Sun, Zhiguang Liu, Qian Zhang
PURPOSE: Molecular mechanisms leading to asthma is still ill-defined. Though the function of microRNAs (miRNAs) in asthma was previously reported, the involvement of miR-155 in important features of this disease remains unknown. The present study was designed to uncover the probable involvement of miR-155-5p in the proliferation and migration of IL-13-induced human bronchial smooth muscle cells (BSMCs) and the intrinsic regulatory mechanism. METHODS: The effects of different concentrations of IL-13 on the proliferation and migration of BSMCs as well as the expression of miR-155-5p and its predicted target transforming growth factor (TGF)-β-activated kinase 1/MAP3K7-binding protein 2 (TAB2) were investigated...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675003/role-of-micrornas-and-exosomes-in-helicobacter-pylori-and-epstein-barr-virus-associated-gastric-cancers
#20
REVIEW
Iva Polakovicova, Sofia Jerez, Ignacio A Wichmann, Alejandra Sandoval-Bórquez, Nicolás Carrasco-Véliz, Alejandro H Corvalán
Emerging evidence suggests that chronic inflammation caused by pathogen infection is connected to the development of various types of cancer. It is estimated that up to 20% of all cancer deaths is linked to infections and inflammation. In gastric cancer, such triggers can be infection of the gastric epithelium by either Helicobacter pylori ( H. pylori ), a bacterium present in half of the world population; or by Epstein-Barr virus (EBV), a double-stranded DNA virus which has recently been associated with gastric cancer...
2018: Frontiers in Microbiology
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