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Anhedonia

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https://www.readbyqxmd.com/read/28630250/amplification-of-mglu5-endocannabinoid-signaling-rescues-behavioral-and-synaptic-deficits-in-a-mouse-model-of-adolescent-and-adult-dietary-polyunsaturated-fatty-acids-imbalance
#1
Antonia Manduca, Anissa Bara, Thomas Larrieu, Olivier Lassalle, Corinne Joffre, Sophie Layé, Olivier J Manzoni
Energy-dense, yet nutritionally-poor food is a high-risk factor for mental health disorders. This is of particular concern during adolescence, a period often associated with increased consumption of low nutritional content food and higher prevalence of mental health disorders. Indeed, there is an urgent need to understand the mechanisms linking unhealthy diet and mental disorders. Deficiency in n-3 polyunsaturated fatty acid (PUFAs) is a hallmark of poor nutrition and mood disorders. Here, we developed a mouse model of n-3 PUFAs deficiency lasting from adolescence into adulthood...
June 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28623880/associations-between-anhedonia-and-marijuana-use-escalation-across-mid-adolescence
#2
Adam M Leventhal, Junhan Cho, Matthew D Stone, Jessica L Barrington-Trimis, Chih-Ping Chou, Steven Y Sussman, Nathaniel R Riggs, Jennifer B Unger, Janet Audrain-McGovern, David R Strong
BACKGROUND AND AIMS: Anhedonia-a transdiagnostic psychopathological trait indicative of inability to experience pleasure-could lead to and result from adolescent marijuana use, yet this notion has not been tested. This study aimed to estimate the association of: (1) anhedonia at age 14 with rate of change in marijuana use over an 18-month follow-up, and (2) marijuana use at age 14 with rate of change in anhedonia over follow-up. Secondary aims were to test whether gender, baseline marijuana use history, and peer marijuana use moderated these associations...
June 17, 2017: Addiction
https://www.readbyqxmd.com/read/28618657/antidepressive-effects-of-ginsenoside-rg1-via-regulation-of-hpa-and-hpg-axis
#3
Zheng Mou, Qian Huang, Shi-Feng Chu, Mei-Jin Zhang, Jin-Feng Hu, Nai-Hong Chen, Jun-Tian Zhang
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity is a well-established pathological feature of major depression, accompanied by the persistent increase of glucocorticoid level and the dysfunction of hypothalamic-pituitary-gonadal (HPG) axis. Ginsenoside Rg1 (Rg1) is one of the most active ingredients of Panax ginseng, which has various biological activity. OBJECTIVE: This study aimed to investigate the antidepressive effects of Rg1 and elucidate its impact on neuroendocrine system...
June 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28617831/depression-in-dementia-with-lewy-bodies-a-comparison-with-alzheimer-s-disease
#4
Pai-Yi Chiu, Chein-Wei Wang, Chun-Tang Tsai, Shin-Hua Li, Chih-Li Lin, Te-Jen Lai
BACKGROUND: Depression is highly associated with dementia, and this study will compare the frequencies, severity, and symptoms of depression between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). METHODS: Frequency of depression was determined according to the DSM-IV criteria for major depression or the National Institute of Mental Health criteria for depression in AD (NIMH-dAD). Severity of depression were assessed using the Hamilton Depression Rating Scale, the Cornell Scale for Depression in Dementia, and the depression subscale in Neuropsychiatric Inventory...
2017: PloS One
https://www.readbyqxmd.com/read/28614554/efficacy-of-a-maternal-depression-prevention-strategy-in-head-start-a-randomized-clinical-trial
#5
Michael Silverstein, Yaminette Diaz-Linhart, Howard Cabral, William Beardslee, Mark Hegel, Winta Haile, Jenna Sander, Gregory Patts, Emily Feinberg
Importance: Low-income and minority mothers experience a disproportionate incidence of depression and lack access to treatment services. Development of prevention strategies in accessible community-based venues is a potentially important public health strategy. Objective: To determine the efficacy of a depression prevention strategy embedded in Head Start. Design, Setting, and Participants: This randomized clinical trial was performed from February 15, 2011, through May 9, 2016, at 6 Head Start agencies serving families at or below the federal poverty level...
June 14, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28600855/predicting-future-major-depression-and-persistent-depressive-symptoms-development-of-a-prognostic-screener-and-phq4-cutoffs-in-breast-cancer-patients
#6
Karen L Weihs, Joshua F Wiley, Catherine M Crespi, Jennifer L Krull, Annette L Stanton
OBJECTIVE: Create a brief, self-report screener for recently diagnosed breast cancer patients to identify patients at risk of future depression. METHODS: Breast cancer patients (N = 410) within 2 ± 1 months after diagnosis provided data on depression vulnerability (DV). Depression outcomes were defined as a high depressive symptom trajectory or a major depressive episode during 16 months after diagnosis. Stochastic gradient boosting of regression trees identified seven items highly predictive for the depression outcomes from a pool of 219 candidate DV items...
June 9, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28597913/inherent-vulnerabilities-in-monoaminergic-pathways-predict-the-emergence-of-depressive-impairments-in-an-animal-model-of-chronic-epilepsy
#7
Jesús-Servando Medel-Matus, Don Shin, Raman Sankar, Andrey Mazarati
The objective was to determine whether the depression comorbid with epilepsy could be predicted based on inherent premorbid patterns of monoaminergic transmission. In male Wistar rats, despair-like and anhedonia-like behaviors were examined using forced swimming and taste preference tests, respectively. Serotonergic raphe nucleus (RN)-prefrontal cortex (PFC) and dopaminergic ventral tegmental area (VTA)-nucleus accumbens (NAcc) pathways were interrogated by fast scan cyclic voltammetry (FSCV). The assays were performed before and 2 months after pilocarpine status epilepticus...
June 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28597553/attenuated-positive-psychotic-symptoms-and-the-experience-of-anhedonia
#8
Shanna Cooper, Ann M Kring, Lauren M Ellman
BACKGROUND: Deficits in anticipatory pleasure have been consistently shown among chronic, first-episode, and clinical high risk for psychosis populations, but much less attention has been given to non-clinical individuals experiencing attenuated positive psychotic symptoms (APPS). METHODS: Young adults (N = 1839) were administered the Temporal Experience of Pleasure Scale, which measures anticipatory and consummatory pleasure, and the Prodromal Questionnaire, which measures APPS...
June 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28596464/-music-processing-in-the-brain-neuropsychological-approach-through-findings-of-patients-with-amusia
#9
Masayuki Satoh
Less than 100 cases of amusia have been reported. The sites of lesion in these patients have been located in the right, left, and bilateral cerebral hemisphere(s); therefore the lateralization of amusia is not as clear as that of aphasia. Among them, pure amusia, the selective loss of musical ability due to acquired brain damage, was observed only in nine cases. The cases of pure amusia included right superior and middle temporal gyrus lesion involvement. By comparing the lesion sites and symptoms of pure amusia, it might be assumed that the right superior/middle temporal gyrus participates in the perception and expression of melody...
June 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28595147/predictors-of-treatment-response-and-drop-out-in-the-treatment-of-early-onset-schizophrenia-spectrum-disorders-teoss-study
#10
Daniel Gabriel, Ewgeni Jakubovski, Jerome H Taylor, Bekir B Artukoglu, Michael H Bloch
The Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) compared the efficacy of risperidone, olanzapine, and molindone over 8 weeks in 119 youths age 8-19 years with early-onset schizophrenia or schizoaffective disorder. From this large dataset, we examined predictors of treatment response and drop out using stepwise regression and receiver operating characteristics curve (ROC) analysis. Treatment response was defined as having both a ≥ 20% improvement in Positive and Negative Syndrome Scale (PANSS) score and a Clinical Global Impression-Improvement (CGI-I) score < 3...
May 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28594207/-psychometric-properties-of-the-ptsd-checklist-for-diagnostic-and-statistical-manual-of-mental-disorders-fifth-edition-pcl-5-in-veterans-correction-to-bovin-et-al-2016
#11
(no author information available yet)
Reports an error in "Psychometric properties of the PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (PCL-5) in veterans" by Michelle J. Bovin, Brian P. Marx, Frank W. Weathers, Matthew W. Gallagher, Paola Rodriguez, Paula P. Schnurr and Terence M. Keane (Psychological Assessment, 2016[Nov], Vol 28[11], 1379-1391). In the article, the departments and affiliations were incorrectly listed for authors Michelle J. Bovin, Brian P. Marx, Matthew W. Gallagher, Paola Rodriguez, Paula P...
June 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28585931/the-modulation-of-adult-neuroplasticity-is-involved-in-the-mood-improving-actions-of-atypical-antipsychotics-in-an-animal-model-of-depression
#12
M Morais, P Patrício, A Mateus-Pinheiro, N D Alves, A R Machado-Santos, J S Correia, J Pereira, L Pinto, N Sousa, J M Bessa
Depression is a prevalent psychiatric disorder with an increasing impact in global public health. However, a large proportion of patients treated with currently available antidepressant drugs fail to achieve remission. Recently, antipsychotic drugs have received approval for the treatment of antidepressant-resistant forms of major depression. The modulation of adult neuroplasticity, namely hippocampal neurogenesis and neuronal remodeling, has been considered to have a key role in the therapeutic effects of antidepressants...
June 6, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28585544/serotonin-modulates-a-depression-like-state-in-drosophila-responsive-to-lithium-treatment
#13
Ariane-Saskia Ries, Tim Hermanns, Burkhard Poeck, Roland Strauss
Major depressive disorder (MDD) affects millions of patients; however, the pathophysiology is poorly understood. Rodent models have been developed using chronic mild stress or unavoidable punishment (learned helplessness) to induce features of depression, like general inactivity and anhedonia. Here we report a three-day vibration-stress protocol for Drosophila that reduces voluntary behavioural activity. As in many MDD patients, lithium-chloride treatment can suppress this depression-like state in flies. The behavioural changes correlate with reduced serotonin (5-HT) release at the mushroom body (MB) and can be relieved by feeding the antidepressant 5-hydroxy-L-tryptophan or sucrose, which results in elevated 5-HT levels in the brain...
June 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28581544/polish-adaptation-of-the-psychache-scale-by-ronald-holden-and-co-workers
#14
Jan Chodkiewicz, Joanna Miniszewska, Dorota Strzelczyk, Krzysztof Gąsior
OBJECTIVES: The conducted study was aimed at making a Polish adaptation of the Scale of Psychache by Ronald Holden and co-workers. The scale is a self-assessment method which comprises 13 statements and is designed to assess subjectively experienced psychological pain. METHODS: 300 persons were examined - undergraduates and postgraduates of the University of Lodz and the Technical University of Lodz. The group of the study participants consisted of 185 women and 115 men...
April 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28575424/association-between-habenula-dysfunction-and-motivational-symptoms-in-unmedicated-major-depressive-disorder
#15
Wen-Hua Liu, Vincent Valton, Ling-Zhi Wang, Yu-Hua Zhu, Jonathan P Roiser
The lateral habenula plays a central role in reward and punishment processing and has been suggested to drive the cardinal symptom of anhedonia in depression. This hypothesis is largely based on observations of habenula hypermetabolism in animal models of depression, but the activity of habenula and its relationship with clinical symptoms in patients with depression remains unclear. High-resolution functional magnetic resonance imaging (fMRI) and computational modelling were used to investigate the activity of the habenula during a probabilistic reinforcement learning task with rewarding and punishing outcomes in 21 unmedicated patients with major depression and 17 healthy participants...
May 29, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28566945/inflammation-opportunities-for-treatment-stratification-among-individuals-diagnosed-with-mood-disorders
#16
Mehala Subramaniapillai, Nicole E Carmona, Carola Rong, Roger S McIntyre
Mood disorders continue to be a significant burden to those affected, resulting in significant illness-associated disability and premature mortality. In addition to mood disturbance, individuals also suffer from other transdiagnostic impairments (eg, anhedonia and cognitive impairment). Although there have been significant advancements in psychiatric treatment over the last few decades, treatment efficacy (eg, symptom remission, lack of functional recovery, and disease modification) continues to be an important limitation...
March 2017: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28558894/depression-severity-and-quality-of-life-of-qualified-and-unqualified-patients-with-a-mood-disorder-for-a-research-study-targeting-anhedonia-in-a-clinical-sample
#17
Keming Gao, Jennifer Sweet, Meilei Su, Joseph R Calabrese
OBJECTIVE: To investigate the depression severity and quality of life of qualified and unqualified patients with a mood disorder for a research study based on anhedonia severity. METHODS: Diagnosis of major depressive disorder (MDD) or bipolar disorder (BPD) was ascertained with the MINI International Neuropsychiatric Interview. The severity of depression was measured with the 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-16-SR), and Item 5, "feeling sad (sadness)," QIDS-16-SR Item 13, "change in general interest," was used to measure the severity of anhedonia...
June 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28555338/the-affective-and-somatic-side-of-depression-subtypes-of-depressive-symptoms-show-diametrically-opposed-associations-with-glycemic-control-in-people-with-type-1-diabetes
#18
Dominic Ehrmann, Andreas Schmitt, André Reimer, Thomas Haak, Bernhard Kulzer, Norbert Hermanns
AIMS: While depression has been linked to serious adverse outcomes in diabetes, associations with glycemic control are not conclusive. Inconsistencies could be due to the complex symptomatology of depression. Aim of this study was to analyze the associations of depressive subtypes with glycemic control in people with type 1 and type 2 diabetes. METHODS: Patients completed the Center for Epidemiological Studies-Depression scale which comprises affective, somatic, and anhedonic symptoms...
May 29, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28555120/psychotic-like-experiences-at-the-healthy-end-of-the-psychosis-continuum
#19
Lui Unterrassner, Thomas A Wyss, Diana Wotruba, Vladeta Ajdacic-Gross, Helene Haker, Wulf Rössler
There is increasing evidence pointing toward a continuous distribution of psychotic symptoms and accompanying factors between subclinical and clinical populations. However, for the construction of continuum models, a more detailed knowledge of different types of psychotic-like experiences (PLE) and their associations with distress, functional impairment, and demographic variables is needed. We investigated PLE in a sample of healthy adults (N = 206) incorporating the recently developed revised Exceptional Experiences Questionnaire (PAGE-R)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28554247/association-of-social-defeat-stress-induced-anhedonia-like-symptoms-with-mglur1-dependent-downregulation-of-membrane-ampa-glur1-in-the-mouse-ventral-midbrain
#20
Sayori Yashiro, Kenjiro Seki
Anhedonia is a core symptom of social defeat stress (SDS)-induced depression associated with the reward system. We previously reported that membrane AMPA-GluR1 downregulation in the reward system is associated with lipopolysaccharide-induced anhedonia-like symptoms. Since group I metabotropic glutamate receptor (mGluR) activation reduces the surface density of GluR1, we examined whether group I mGluR-dependent membrane GluR1 downregulation in the reward system is involved in SDS-induced anhedonia-like symptoms...
May 29, 2017: Stress: the International Journal on the Biology of Stress
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