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https://www.readbyqxmd.com/read/29355374/olfactory-bulbectomy-in-methamphetamine-treated-rat-mothers-induces-impairment-in-somatic-and-functional-development-of-their-offspring
#1
R Šlamberová, J Rudá-Kučerová, Z Babinská, M Ševčíková
Olfactory bulbectomy in rodents is considered a putative model of depression. Depression is often associated with drug addiction. Our previous studies demonstrated that methamphetamine (MA) administration to rat mothers affects both, mothers and their pups. The aim of the present study was to examine the effect of bulbectomy, as a model of depression, and MA administration on behavior of rat mothers and postnatal development of their pups. Adult female Wistar rats were randomly divided into two groups: bulbectomized (OBX) and sham-operated (SH)...
December 30, 2017: Physiological Research
https://www.readbyqxmd.com/read/29352556/what-causes-psychosis-an-umbrella-review-of-risk-and-protective-factors
#2
Joaquim Radua, Valentina Ramella-Cravaro, John P A Ioannidis, Abraham Reichenberg, Nacharin Phiphopthatsanee, Taha Amir, Hyi Yenn Thoo, Dominic Oliver, Cathy Davies, Craig Morgan, Philip McGuire, Robin M Murray, Paolo Fusar-Poli
Psychosis is a heterogeneous psychiatric condition for which a multitude of risk and protective factors have been suggested. This umbrella review aimed to classify the strength of evidence for the associations between each factor and psychotic disorders whilst controlling for several biases. The Web of Knowledge database was searched to identify systematic reviews and meta-analyses of observational studies which examined associations between socio-demographic, parental, perinatal, later factors or antecedents and psychotic disorders, and which included a comparison group of healthy controls, published from 1965 to January 31, 2017...
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/29352029/dissociable-temporal-effects-of-bupropion-on-behavioural-measures-of-emotional-and-reward-processing-in-depression
#3
Annabel E L Walsh, Michael Browning, Wayne C Drevets, Maura Furey, Catherine J Harmer
Antidepressants remediate negative biases in emotional processing early in treatment, prior to mood improvement. However, the effects on reward processing potentially relevant to the treatment of anhedonia are less clear. Here we investigate the early and sustained effects of the dopamine and noradrenaline reuptake inhibitor bupropion on behavioural measures of emotional and reward processing in currently depressed individuals. Forty-six currently depressed patients and 42 healthy controls participated in a repeated measures study, during which open-label bupropion was administered to only the patient group over a six week period without a placebo group...
March 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29351316/dexmedetomidine-reduces-lipopolysaccharide-induced-neuroinflammation-sickness-behavior-and-anhedonia
#4
Ching-Hua Yeh, Liang-Po Hsieh, Ming-Chung Lin, Tsui-Shan Wei, Hui-Ching Lin, Chia-Cheng Chang, Chung-Hsi Hsing
BACKGROUND: Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)-induced neuroinflammation and sickness behavior in mice. MATERIALS AND METHODS: BALB/c mice were intraperitoneally (i.p.) injected with Dex (50 ug/kg) or vehicle. One hour later, the mice were injected (i...
2018: PloS One
https://www.readbyqxmd.com/read/29329063/seasonality-of-depressive-symptoms-in-women-but-not-in-men-a-cross-sectional-study-in-the-uk-biobank-cohort
#5
Laura M Lyall, Cathy A Wyse, Carlos A Celis-Morales, Donald M Lyall, Breda Cullen, Daniel Mackay, Joey Ward, Nicholas Graham, Rona J Strawbridge, Jason M R Gill, Amy Ferguson, Mark E S Bailey, Jill P Pell, Annie M Curtis, Daniel J Smith
BACKGROUND: We examined whether seasonal variations in depressive symptoms occurred independently of demographic and lifestyle factors, and were related to change in day length and/or outdoor temperature. METHODS: In a cross-sectional analysis of >150,000 participants of the UK Biobank cohort, we used the cosinor method to assess evidence of seasonality of a total depressive symptoms score and of low mood, anhedonia, tenseness and tiredness scores in women and men...
January 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29326031/depressive-symptoms-and-poorer-performance-on-the-stroop-task-are-associated-with-weight-gain
#6
Emma J Stinson, Jonathan Krakoff, Marci E Gluck
OBJECTIVE: Executive function impairments and depression are associated with obesity but whether they predict weight gain is unclear. METHODS: Forty-six individuals (35m, 37±10y) completed the Stroop Task, Iowa Gambling Task (IGT), Wisconsin Card Sorting Task (WCST), Inventory for Depressive Symptomatology (IDS-SR), Physical Anhedonia Scale (PAS), and Perceived Stress Scale (PSS). Body composition (DXA) and fasting glucose were also measured. Data from return visits were used to assess changes in weight...
January 8, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29325447/longitudinal-association-of-amyloid-beta-and-anxious-depressive-symptoms-in-cognitively-normal-older-adults
#7
Nancy J Donovan, Joseph J Locascio, Gad A Marshall, Jennifer Gatchel, Bernard J Hanseeuw, Dorene M Rentz, Keith A Johnson, Reisa A Sperling
OBJECTIVE: To understand the role of depressive symptoms in preclinical Alzheimer's disease, it is essential to define their temporal relationship to Alzheimer's proteinopathies in cognitively normal older adults. The study objective was to examine associations of brain amyloid beta and longitudinal measures of depression and depressive symptom clusters in a cognitively normal sample of older adults. METHOD: A total of 270 community-dwelling, cognitively normal elderly individuals underwent baseline Pittsburgh compound B (PiB) positron emission tomography (PET) measures of cortical aggregate amyloid beta and annual assessments with the 30-item Geriatric Depression Scale (GDS)...
January 12, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29308221/cognitive-bias-modification-for-facial-interpretation-a-randomized-controlled-trial-of-transfer-to-self-report-and-cognitive-measures-in-a-healthy-sample
#8
S E Peters, J Lumsden, O H Peh, I S Penton-Voak, M R Munafò, O J Robinson
Cognitive bias modification is a potential low-intensity intervention for mood disorders, but previous studies have shown mixed success. This study explored whether facial interpretation bias modification (FIBM), a similar paradigm designed to shift emotional interpretation (and/or perception) of faces would transfer to: (i) self-reported symptoms and (ii) a battery of cognitive tasks. In a preregistered, double-blind randomized controlled trial, healthy participants received eight online sessions of FIBM (N = 52) or eight sham sessions (N = 52)...
December 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29307665/effects-of-ketamine-on-vocal-impairment-gait-changes-and-anhedonia-induced-by-bilateral-6-ohda-infusion-into-the-substantia-nigra-pars-compacta-in-rats-therapeutic-implications-for-parkinson-s-disease
#9
Débora Dalla Vecchia, Luiz Kae Sales Kanazawa, Etiéli Wendler, Palloma de Almeida Soares Hocayen, Estevan Bruginski, Francinete Ramos Campos, Cristina Aparecida Jark Stern, Maria Aparecida Barbato Frazão Vital, Edmar Miyoshi, Markus Wöhr, Rainer K W Schwarting, Roberto Andreatini
Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e.g. difficulties to articulate words and to keep the tone of voice) and depression. In the present study, rats with bilateral 6-hydroxydopamine lesion of the substantia nigra pars compacta were evaluated for changes in the emission of 50-kHz ultrasonic vocalizations, gait impairment (catwalk test), and depressive-like behaviour (sucrose preference test).Furthermore, we evaluated the effect of repeated treatment (28 days) with ketamine (5, 10, and 15 mg/kg, ip, once per week) or imipramine (15 mg/kg, ip, daily)...
January 4, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29305655/chrfam7a-gene-expression-in-schizophrenia-clinical-correlates-and-the-effect-of-antipsychotic-treatment
#10
Sunil V Kalmady, Rimjhim Agrawal, Deepthi Venugopal, Venkataram Shivakumar, Anekal C Amaresha, Sri Mahavir Agarwal, Manjula Subbanna, Ashwini Rajasekaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
Earlier studies have implicated CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), and its partially duplicated chimeric gene CHRFAM7A in schizophrenia. However, the relationship between the alterations in peripheral gene expression of CHRFAM7A and severity of clinical symptoms has not been examined. Furthermore, potential influence of the antipsychotic medication on CHRFAM7A expression in drug-naive or drug-free schizophrenia is an unexplored area. CHRFAM7A gene expression in lymphocytes was analyzed in 90 antipsychotic-naïve or free schizophrenia patients using TaqMan-based quantitative RT-PCR...
January 5, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29304053/prior-exposure-to-corticosterone-markedly-enhances-and-prolongs-the-neuroinflammatory-response-to-systemic-challenge-with-lps
#11
Kimberly A Kelly, Lindsay T Michalovicz, Julie V Miller, Vincent Castranova, Diane B Miller, James P O'Callaghan
Systemic exposure to the inflammagen and bacterial endotoxin lipopolysaccharide (LPS) has been widely used to evaluate inflammation and sickness behavior. While many inflammatory conditions occur in the periphery, it is well established that peripheral inflammation can affect the brain. Neuroinflammation, the elaboration of proinflammatory mediators in the CNS, commonly is associated with behavioral symptoms (e.g., lethargy, anhedonia, anorexia, depression, etc.) termed sickness behavior. Stressors have been shown to interact with and alter neuroinflammatory responses and associated behaviors...
2018: PloS One
https://www.readbyqxmd.com/read/29295011/the-association-among-parental-bonding-depression-social-aggression-and-criminal-assault-are-there-gender-differences-between-male-and-female-youth-offenders
#12
John Tisak, Marie S Tisak, Erin R Baker, Kelly E Amrhein, Cjersti Jensen
This research examined similarities and differences in gender regarding social aggression, criminal assault, depression, and familial factors. The participants were 251 youth offenders (158 males) who were arrested and incarcerated in a juvenile facility. The measures consisted of self-reported acts of social aggression, simple and aggravated assault, subtypes of depression, and self-reports on parental care and control. Our data demonstrate the importance of including gender, types of aggression/assault, subtypes of depression, and familial factors when examining their association...
November 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29291430/the-potential-benefit-of-combined-versus-monotherapy-of-coenzyme-q10-and-fluoxetine-on-depressive-like-behaviors-and-intermediates-coupled-to-gsk-3%C3%AE-in-rats
#13
Sally A Abuelezz, Nevien Hendawy, Yosra Magdy
As a part of the serotoninergic dysfunction implicated in neurobiology of depression, evidence has focused on serotonin (5-HT) receptors downstream signaling intermediates including glycogen synthase kinase-3β (GSK-3β), cAMP response element binding protein (CREB) and brain derived neurotrophic factor (BDNF). Our team previously reported that coenzyme Q10 (CoQ10) exerted antidepressant-like effect in rats exposed to chronic unpredictable mid stress (CUMS) via elevating serotonin levels. However, the effect of CoQ10 has not been elucidated in downstream signaling molecules mediating 5HT receptors' effect involved in depressive disorder hitherto...
December 29, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29288725/both-ketamine-and-nbqx-attenuate-alcohol-drinking-in-male-wistar-rats
#14
Jana Ruda-Kucerova, Zuzana Babinska, Matej Luptak, Bruk Getachew, Yousef Tizabi
The devastating consequences of alcohol-use disorder (AUD) on the individual and the society are well established. Current treatments of AUD encompass various strategies, all of which have only modest effectiveness. Hence, there is a critical need to develop more efficacious therapies. Recently, specific glutamatergic receptors have been identified as potential novel targets for intervention in AUD. Thus, the current study was designed to evaluate the effects of acute administration of sub-anesthetic doses of ketamine, an NMDA receptor antagonist, as well as NBQX, an AMPA/kainate receptor antagonist on alcohol intake and its possible behavioural consequences...
December 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29282816/methamphetamine-binge-administration-dose-dependently-enhanced-negative-affect-and-voluntary-drug-consumption-in-rats-following-prolonged-withdrawal-role-of-hippocampal-fadd
#15
Rubén García-Cabrerizo, M Julia García-Fuster
While prior studies have established various interacting mechanisms and neural consequences (i.e. monoaminergic nerve terminal damage) that might contribute to the adverse effects caused by methamphetamine administration, the precise mechanisms that mediate relapse during withdrawal remain unknown. This study evaluated the long-term consequences of binge methamphetamine administration (three pulses/day, every 3 hours, 4 days, i.p.; dose-response: 2.5, 5 and 7.5 mg/kg) in adult Sprague-Dawley rats at two behavioral levels following 25 days of withdrawal: (1) negative affect (behavioral despair-forced-swim test, and anhedonia-1% sucrose consumption, two-bottle choice test) and (2) voluntary methamphetamine consumption (20 mg/l, two-bottle choice test)...
December 28, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29276350/pleasure-experience-and-emotion-expression-in-patients-with-schizophrenia
#16
Min-Yi Chu, Xu Li, Qin-Yu Lv, Zheng-Hui Yl, Eric F C Cheung, Raymond C K Chan
Background: Impairments in emotional experience and expression have been observed in patients with schizophrenia. However, most previous studies have been limited to either emotional experience (especially anhedonia) or expression. Few studies have examined both the experience and expression of emotion in schizophrenia patients at the same time. Aims: The present study aimed to examine pleasure experience and emotion expression in patients with schizophrenia. In particular, we specifically examined the relationship between emotion impairments (both pleasure experience and expression) and negative symptoms...
October 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29275856/the-brief-negative-symptom-scale-bnss-sensitivity-to-treatment-effects
#17
Brian Kirkpatrick, Jay B Saoud, Gregory P Strauss, Anthony O Ahmed, Kazunori Tatsumi, Mark Opler, Remy Luthringer, Michael Davidson
The Brief Negative Symptom Scale (BNSS) grew out of a recommendation by the NIMH-sponsored Consensus Development Conference on Negative Symptoms that a scale based on contemporary concepts be developed. We assessed sensitivity to change of the BNSS in a trial of MIN-101, which showed efficacy for negative symptoms (PANSS pentagonal model) at daily doses of 32 and 64mg/day. Using mixed-effects model for repeated measures, we examined change in BNSS total score and in the BNSS factors of anhedonia/avolition/asociality (AAA), and expressivity (EXP)...
December 21, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29258860/multiple-trial-inhibitory-avoidance-acquisition-and-retrieval-are-resistant-to-chronic-stress
#18
J Raya, C E N Girardi, L A Esumi, L B T Ferreira, D C Hipólide
Chronic mild stress (CMS) is a widely accepted animal model relevant to depression that among other consequences, is chiefly known to induce anhedonia, often assessed as decreased preference for sucrose solution. CMS is also known to affect cognition, particularly memory tasks. In this study we have employed the multiple-trial inhibitory avoidance memory task (MTIA) to assess CMS effects on memory acquisition and retrieval. MTIA consists of repeated exposures to the unconditioned stimulus until a learning criterion is reached...
December 16, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/29251178/putamen-volume-differences-among-older-adults-depression-status-melancholia-and-age
#19
Natalie J Sachs-Ericsson, Greg Hajcak, Julia L Sheffler, Ian H Stanley, Edward A Selby, Guy G Potter, David C Steffens
BACKGROUND: Individuals with major depressive disorder (MDD) may exhibit smaller striatal volumes reflecting deficits in the reward circuit. Deficits may change with age and be more pronounced among the melancholic subtype. Limited research has investigated striatal volume differences in older adults and by depression subtypes. METHOD: We used baseline data from the Neurocognitive Outcomes of Depression in the Elderly study. We examined volumetric differences in the putamen and caudate nucleus among older adults (60 years and older), comparing healthy control participants (n = 134) to depressed participants (n = 226), and comparing nonmelancholic depressed participants (n = 93) to melancholic depressed participants (n = 133)...
January 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29249992/gender-differences-and-psychopathological-features-associated-with-addictive-behaviors-in-adolescents
#20
Marco Di Nicola, Vittoria Rachele Ferri, Lorenzo Moccia, Isabella Panaccione, Annamaria Miriam Strangio, Daniela Tedeschi, Paolo Grandinetti, Antonino Callea, Fabio De-Giorgio, Giovanni Martinotti, Luigi Janiri
Background: The aims of the study were to assess prevalence and gender differences of addictive behaviors (substance- and non-substance-related) in an adolescent population, and their association with psychopathological features and academic performance. Material and methods: A sample of high school Italian students (n = 996; M = 240, F = 756) was examined using a self-report survey concerning sociodemographic characteristics, cigarette smoking, alcohol and substance use, perceived academic performance, activities, and behaviors (Internet use, gambling, and physical exercising)...
2017: Frontiers in Psychiatry
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