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Efferocytosis

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https://www.readbyqxmd.com/read/29763901/5-aminolevulinic-acid-mediated-sonodynamic-therapy-alleviates-atherosclerosis-via-enhancing-efferocytosis-and-facilitating-a-shift-in-the-th1-th2-balance-toward-th2-polarization
#1
Yang Yang, Yuanyuan Liu, Xi Chen, Jie Gong, Zhen Huang, Wei Wang, Yuanqi Shi, Yu Wang, Jianting Yao, Zhaoqian Shen, Zhen Tian, Hong Jin, Ye Tian
BACKGROUND/AIMS: We and other groups have demonstrated that 5-aminolevulinic acid (ALA)-mediated sonodynamic therapy (ALA-SDT) induces macrophage and foam cell apoptosis and stabilizes atherosclerosis (AS) plaques in animal models. Lymphocytes also play vital roles in the development of AS. The primary purpose of the present study was to investigate the effects of ALA-SDT on T helper (Th) cell fate and function, Th subset differentiation, and atherosclerotic lesion stability. METHODS: We utilized ALA-SDT on Western diet-fed apoE-/-mice in vivo and human Jurkat cells in vitro...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29755460/proteinase-3-interferes-with-c1q-mediated-clearance-of-apoptotic-cells
#2
Pascale Tacnet-Delorme, Julie Gabillet, Simon Chatfield, Nathalie Thieblemont, Philippe Frachet, Véronique Witko-Sarsat
Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Moreover, PR3 is a serine protease whose membrane expression can potentiate inflammatory diseases such as ANCA-associated vasculitis and rheumatoid arthritis. During apoptosis, PR3 is co-externalized with phosphatidylserine (PS) and is known to modulate the clearance of apoptotic cells through a calreticulin (CRT)-dependent mechanism...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29718706/myc-nick-promotes-efferocytosis-through-m2-macrophage-polarization-during-resolution-of-inflammation
#3
Xiancai Zhong, Ha-Na Lee, Seung Hyeon Kim, Sin-Aye Park, Wonki Kim, Young-Nam Cha, Young-Joon Surh
A key event required for effective resolution of inflammation is efferocytosis, which is defined as phagocytic removal of apoptotic cells mostly by macrophages acquiring an alternatively activated phenotype (M2). c-Myc has been reported to play a role in alternative activation of human macrophages and is proposed as one of the M2 macrophage markers. We found that M2-like peritoneal macrophages from zymosan A-treated mice exhibited a marked accumulation of Myc-nick, a truncated protein generated by a Calpain-mediated proteolytic cleavage of full-length c-Myc...
May 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29706963/protective-role-of-the-mer-tyrosine-kinase-via-efferocytosis-in-rheumatoid-arthritis-models
#4
Claire E J Waterborg, Silke Beermann, Mathijs G A Broeren, Miranda B Bennink, Marije I Koenders, Peter L E M van Lent, Wim B van den Berg, Peter M van der Kraan, Fons A J van de Loo
Objective: Rheumatoid arthritis (RA) is a chronic and progressive joint disease. It appears that anti-inflammatory feedback mechanisms that could restrain joint inflammation and restore homeostasis are insufficient to perform this control. In this study, we investigated the contribution of the MER tyrosine kinase-mediated anti-inflammatory response on arthritis and whether targeting MER could be a valid approach to treat RA. Methods: KRN serum transfer arthritis (KRN STA) was induced in either Mertk -deficient mice or in mice that adenovirally overexpressed Pros1 ...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29696149/anti-inflammatory-benefits-of-antibiotics-tylvalosin-induces-apoptosis-of-porcine-neutrophils-and-macrophages-promotes-efferocytosis-and-inhibits-pro-inflammatory-cxcl-8-il1%C3%AE-and-ltb-4-production-while-inducing-the-release-of-pro-resolving-lipoxin-a-4-and-resolvin
#5
Ruth Moges, Dimitri Desmonts De Lamache, Saman Sajedy, Bernard S Renaux, Morley D Hollenberg, Gregory Muench, Elizabeth M Abbott, Andre G Buret
Excessive accumulation of neutrophils and their uncontrolled death by necrosis at the site of inflammation exacerbates inflammatory responses and leads to self-amplifying tissue injury and loss of organ function, as exemplified in a variety of respiratory diseases. In homeostasis, neutrophils are inactivated by apoptosis, and non phlogistically removed by neighboring macrophages in a process known as efferocytosis, which promotes the resolution of inflammation. The present study assessed the potential anti-inflammatory and pro-resolution benefits of tylvalosin, a recently developed broad-spectrum veterinary macrolide derived from tylosin...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29693767/7-ketocholesterol-impairs-phagocytosis-and-efferocytosis-via-dysregulation-of-phosphatidylinositol-4-5-bisphosphate
#6
Stella M Lu, Gregory D Fairn
The plasma membrane is inhomogeneously organized containing both highly ordered and disordered nanodomains. 7-Ketocholesterol (7KC), an oxysterol formed from the non-enzymatic oxidation of cholesterol, is a potent disruptor of membrane order. Importantly, 7KC is a component of oxidized LDL and accumulates in macrophage and foam cells found in arterial plaques. Using a murine macrophage cell line, J774, we report that both IgG-mediated and phosphatidylserine (PtdSer)-mediated phagocytic pathways are inhibited by the accumulation of 7KC...
April 24, 2018: Traffic
https://www.readbyqxmd.com/read/29693725/tctex-1-a-novel-interaction-partner-of-kidney-injury-molecule-1-is-required-for-efferocytosis
#7
Ola Z Ismail, Saranga Sriranganathan, Xizhong Zhang, Joseph V Bonventre, Antonis S Zervos, Lakshman Gunaratnam
Kidney injury molecule-1 (KIM-1) is a phosphatidylserine receptor that is specifically upregulated on proximal tubular epithelial cells (PTECs) during acute kidney injury and mitigates tissue damage by mediating efferocytosis (the phagocytic clearance of apoptotic cells). The signaling molecules that regulate efferocytosis in TECs are not well understood. Using a yeast two-hybrid screen, we identified the dynein light chain protein, Tctex-1, as a novel KIM-1-interacting protein. Immunoprecipitation and confocal imaging studies suggested that Tctex-1 associates with KIM-1 in cells at baseline, but, dissociates from KIM-1 within 90 min of initiation of efferocytosis...
April 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29656339/role-of-ampk-in-atherosclerosis-via-autophagy-regulation
#8
REVIEW
Hanxiao Ou, Chuhao Liu, Wenjie Feng, Xinwen Xiao, Shengsong Tang, Zhongcheng Mo
Atherosclerosis is characterized by the accumulation of lipids and deposition of fibrous elements in the vascular wall, which is the primary cause of cardiovascular diseases. Adenosine monophosphate-activated protein kinase (AMPK) is a metabolic sensor of energy metabolism that regulates multiple physiological processes, including lipid and glucose metabolism and the normalization of energy imbalances. Overwhelming evidence indicates that AMPK activation markedly attenuates atherosclerosis development. Autophagy inhibits cell apoptosis and inflammation and promotes cholesterol efflux and efferocytosis...
April 12, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29650255/glucocorticoid-loaded-liposomes-induce-a-pro-resolution-phenotype-in-human-primary-macrophages-to-support-chronic-wound-healing
#9
Anne Gauthier, Andreas Fisch, Klaus Seuwen, Birgit Baumgarten, Heinz Ruffner, Alexandra Aebi, Martin Rausch, Fabian Kiessling, Matthias Bartneck, Ralf Weiskirchen, Frank Tacke, Gert Storm, Twan Lammers, Marie-Gabrielle Ludwig
Glucocorticoids are well established anti-inflammatory agents, however, their use to treat chronic inflammatory diseases is limited due to a number of serious side effects. For example, long-term local treatment of chronic wounds with glucocorticoids is prohibited by dysregulation of keratinocyte and fibroblast function, leading to skin thinning. Here, we developed and tested liposome formulations for local delivery of dexamethasone to primary human macrophages, to drive an anti-inflammatory/pro-resolution phenotype appropriate for tissue repair...
April 5, 2018: Biomaterials
https://www.readbyqxmd.com/read/29643857/a-17-kda-fragment-of-lactoferrin-associates-with-the-termination-of-inflammation-and-peptides-within-promote-resolution
#10
Aviv Lutaty, Soaad Soboh, Sagie Schif-Zuck, Orly Zeituni-Timor, Ran Rostoker, Malgorzata J Podolska, Christine Schauer, Martin Herrmann, Luis E Muñoz, Amiram Ariel
During the resolution of inflammation, macrophages engulf apoptotic polymorphonuclear cells (PMN) and can accumulate large numbers of their corpses. Here, we report that resolution phase macrophages acquire the neutrophil-derived glycoprotein lactoferrin (Lf) and fragments thereof in vivo and ex vivo . During the onset and resolving phases of inflammation in murine peritonitis and bovine mastitis, Lf fragments of 15 and 17 kDa occurred in various body fluids, and the murine fragmentation, accumulation, and release were mediated initially by neutrophils and later by efferocytic macrophages...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29618478/nadph-oxidase-activation-regulates-apoptotic-neutrophil-clearance-by-murine-macrophages
#11
Juhi Bagaitkar, Jing Huang, Melody Yue Zeng, Nancy K Pech, Darlene A Monlish, Lizet J Perez-Zapata, Irina Miralda, Laura G Schuettpelz, Mary C Dinauer
The phagocyte NADPH oxidase generates superoxide, the precursor to reactive oxygen species (ROS) that have both antimicrobial and immunoregulatory functions. Inactivating mutations in NADPH oxidase alleles cause chronic granulomatous disease (CGD), characterized by enhanced susceptibility to life-threatening microbial infections and inflammatory disorders, and hypomorphic NADPH oxidase alleles are associated with autoimmunity. Impaired apoptotic cell (AC) clearance is implicated as an important contributing factor in chronic inflammation and autoimmunity, but the role of NADPH oxidase-derived ROS in this process is incompletely understood...
April 4, 2018: Blood
https://www.readbyqxmd.com/read/29593730/cd5l-promotes-m2-macrophage-polarization-through-autophagy-mediated-upregulation-of-id3
#12
Lucía Sanjurjo, Gemma Aran, Érica Téllez, Núria Amézaga, Carolina Armengol, Daniel López, Clara Prats, Maria-Rosa Sarrias
CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer. In macrophages, CD5L promotes an anti-inflammatory cytokine profile in response to TLR activation. In the present study, we questioned whether CD5L is able to influence human macrophage plasticity, and drive its polarization toward any specific phenotype. We compared CD5L-induced phenotypic and functional changes to those caused by IFN/LPS, IL4, and IL10 in human monocytes...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29571326/identification-and-complete-stereochemical-assignments-of-the-new-resolvin-conjugates-in-tissue-regeneration-in-human-tissues-that-stimulate-proresolving-phagocyte-functions-and-tissue-regeneration
#13
Xavier de la Rosa, Paul C Norris, Nan Chiang, Ana R Rodriguez, Bernd W Spur, Charles N Serhan
Resolvin conjugates in tissue regeneration (RCTRs) are new chemical signals that accelerate resolution of inflammation, infection, and tissue regeneration. Herein, using liquid chromatography-tandem mass spectrometry-based metabololipidomics, we identified RCTRs in human spleen, lymph node, bone marrow, and brain. In human spleen incubated with Staphylococcus aureus, endogenous RCTRs were increased along with conversion of deuterium-labeled docosahexaenoic acid, conferring pathway activation. Physical and biological properties of endogenous RCTRs were matched with those prepared by total organic synthesis...
April 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29545796/macrophage-derived-protein-s-facilitates-apoptotic-polymorphonuclear-cell-clearance-by-resolution-phase-macrophages-and-supports-their-reprogramming
#14
Delphine Lumbroso, Soaad Soboh, Avi Maimon, Sagie Schif-Zuck, Amiram Ariel, Tal Burstyn-Cohen
The complete resolution of inflammation requires the uptake of apoptotic polymorphonuclear cells (PMN) by local macrophages (efferocytosis) and the consequent reprogramming of the engulfing phagocytes to reparative and pro-resolving phenotypes. The tyrosine kinase receptors TYRO3, AXL, and MERTK (collectively named TAM) are fundamental mediators in regulating inflammatory responses and efferocytosis. Protein S (PROS1) is a ligand for all TAM receptors that mediates various aspects of their activity. However, the involvement of PROS1 in the resolution of inflammation is incompletely understood...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29544524/defective-formyl-peptide-receptor-2-3-and-annexin-a1-expressions-associated-with-m2a-polarization-of-blood-immune-cells-in-patients-with-chronic-obstructive-pulmonary-disease
#15
Yung-Che Chen, Meng-Chih Lin, Chih-Hung Lee, Shih-Feng Liu, Chin-Chou Wang, Wen-Feng Fang, Tung-Ying Chao, Chao-Chien Wu, Yu-Feng Wei, Huang-Chih Chang, Chia-Cheng Tsen, Hung-Chen Chen
BACKGROUND: Controversy exists in previous studies on macrophage M1/M2 polarization in chronic obstructive pulmonary disease (COPD). We hypothesized that formyl peptide receptor (FPR), a marker of efferocytosis and mediator of M1/M2 polarization, may be involved in the development of COPD. METHODS: We examined FPR 1/2/3 expressions of blood M1/M2a monocyte, neutrophil, natural killer (NK) cell, NK T cell, T helper (Th) cell, and T cytotoxic (Tc) cell by flowcytometry method in 40 patients with cigarette smoking-related COPD and 16 healthy non-smokers...
March 15, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29543397/alternative-rna-splicing-of-leukocyte-tissue-transglutaminase-in-celiac-disease
#16
Ana Hernández, Paula Arbildi, Cecilia Sóñora, Natalia Del Río, Juan Martin Marques
Tissue transglutaminase is a ubiquitous and multifunctional protein that contribute to several processes such as apoptosis/survival, efferocytosis, inflammation and tissue repairing under physiological and pathological conditions. Several activities can be associated with well established functional domains; in addition, four RNA alternative splice variants have been described, characterized by sequence divergences and residues deletion at the C-terminal domains Tissue transglutaminase is recognized as the central player in the physiopathology of celiac disease mainly through calcium dependent enzymatic activities...
March 15, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29523554/lysosomal-cholesterol-hydrolysis-couples-efferocytosis-to-anti-inflammatory-oxysterol-production
#17
Manon Viaud, Stoyan Ivanov, Nemanja Vujic, Madalina Duta-Mare, Lazaro-Emilio Aira, Thibault Barouillet, Elsa Garcia, François Orange, Isabelle Dugail, Isabelle Hainault, Christian Stehlik, Sandrine Marchetti, Laurent Boyer, Rodolphe Guinamard, Fabienne Foufelle, Andrea E Bochem, Kees G Hovingh, Edward B Thorp, Emmanuel L Gautier, Dagmar Kratky, Paul A Da Silva-Jardine, Laurent Yvan-Charvet
<u>Rationale:</u> Macrophages face a substantial amount of cholesterol following the ingestion of apoptotic cells and the lysosomal acid lipase (LIPA) has a major role in hydrolyzing cholesteryl esters in the endocytic compartment. <u>Objective:</u> Here, we directly investigated the role of LIPA-mediated clearance of apoptotic cells both in vitro and in vivo. <u>Methods and Results:</u> We show that LIPA inhibition causes a defective efferocytic response due to impaired generation of 25-OHC and 27-OHC...
March 9, 2018: Circulation Research
https://www.readbyqxmd.com/read/29514053/the-role-of-tam-family-receptors-and-ligands-in-the-nervous-system-from-development-to-pathobiology
#18
REVIEW
Bridget Shafit-Zagardo, Ross C Gruber, Juwen C DuBois
Tyro3, Axl, and Mertk, referred to as the TAM family of receptor tyrosine kinases, are instrumental in maintaining cell survival and homeostasis in mammals. TAM receptors interact with multiple signaling molecules to regulate cell migration, survival, phagocytosis and clearance of metabolic products and cell debris called efferocytosis. The TAMs also function as rheostats to reduce the expression of proinflammatory molecules and prevent autoimmunity. All three TAM receptors are activated in a concentration-dependent manner by the vitamin K-dependent growth arrest-specific protein 6 (Gas6)...
March 4, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29512142/liposome-preparation-for-the-analysis-of-lipid-receptor-interaction-and-efferocytosis
#19
Oliver H Voss, Ha-Na Lee, Linjie Tian, Konrad Krzewski, John E Coligan
Efficient phagocytosis of apoptotic cells (efferocytosis) is essential for immune homeostasis. Phospholipids exposed on the surface of apoptotic cells, such as phosphatidylserine, supply important "eat-me" signals. Liposomes are lipid bilayer vesicles that can be generated from one or several types of phospholipids of interest. Thus, these vesicles offer versatility, flexibility, and, importantly, a three-dimensional structure for studying the interaction between lipids and their receptors as well as the lipid-receptor interaction-mediated signaling events controlling efferocytosis by cells like professional phagocytes...
February 21, 2018: Current Protocols in Immunology
https://www.readbyqxmd.com/read/29510393/a-stat6-inhibitor-as1517499-reduces-preventive-effects-of-apoptotic-cell-instillation-on-bleomycin-induced-lung-fibrosis-by-suppressing-ppar%C3%AE
#20
Myeong-Joo Kim, Ye-Ji Lee, Young-So Yoon, Jae H Lim, Eun-Mi Park, Young H Chong, Jihee Lee Kang
BACKGROUND/AIMS: The signal transducer and activator of transcription 6 (STAT6) transcription factor mediates PPARγ-regulated gene expression in macrophages. However, it remains largely unknown how proximal membrane signaling events initiated by apoptotic cell recognition upregulate PPARγ expression and activate the lung homeostatic program. METHODS: The STAT6 inhibitor AS1517499 was used to determine the role of STAT6 in mediating PPARγ activity, anti-inflammatory effects, and anti-fibrotic effects induced by apoptotic cell instillation after bleomycin treatment into C57BL/6 mice...
2018: Cellular Physiology and Biochemistry
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