keyword
MENU ▼
Read by QxMD icon Read
search

Death clearance

keyword
https://www.readbyqxmd.com/read/28329181/treatment-response-in-enteric-fever-in-an-era-of-increasing-antimicrobial-resistance-an-individual-patient-data-analysis-of-2-092-participants-enrolled-into-four-randomised-controlled-trials-in-nepal
#1
Corinne N Thompsom, Abhilasha Karkey, Sabina Dongol, Amit Ariyal, Marcel Wolbers, Thomas Darton, Jeremey J Farrar, Guy E Thwaites, Christiane Dolecek, Buddha Basnyat, Stephen Baker
Background: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cause of bacterial febrile disease in South Asia. Methods: Individual patient data from 2,092 subjects with enteric fever randomised into four trials in Kathmandu, Nepal was pooled. All trials compared gatifloxacin with a comparator drug: cefixime, chloramphenicol, ofloxacin, or ceftriaxone. Treatment outcomes were evaluated according to antimicrobial if S. Typhi/Paratyphi were isolated from blood...
February 28, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28317872/preclinical-evaluation-of-the-efficacy-pharmacokinetics-and-immunogenicity-of-js-001-a-programmed-cell-death-protein-1-pd-1-monoclonal-antibody
#2
Jie Fu, Fang Wang, Li-Hou Dong, Jing Zhang, Cheng-Lian Deng, Xue-Li Wang, Xin-Yao Xie, Jing Zhang, Ruo-Xian Deng, Li-Bo Zhang, Hai Wu, Hui Feng, Bo Chen, Hai-Feng Song
JS-001 is the first monoclonal antibody (mAb) against programmed cell death protein-1 (PD-1) approved by the China Food and Drug Administration (CFDA) into the clinical trails. To date, however, no pre-clinical pharmacological and pharmacokinetic (PK) data are available. In this study, we investigated the efficacy of JS-001 and conducted a preclinical PK study, including the monitoring of anti-drug antibodies (ADAs). We found that JS-001 specifically bound to PD-1 antigen with an EC50 of 21 nmol/L, and competently blocked the binding of PD-1 antigen to PD-L1 and PD-L2 with IC50 of 3...
March 20, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28292724/deleterious-role-of-trace-elements-silica-and-lead-in-the-development-of-chronic-kidney-disease
#3
Starlaine Mascarenhas, Srikanth Mutnuri, Anasuya Ganguly
Chronic-Kidney-Disease of Unknown-etiology (CKDu) has been reported in developing-countries like Sri-Lanka, India and Central-America without sparing the Indian sub-district (namely Canacona) located in south-Goa. The disease etiology is unlinked to common causes of diabetes and hypertension and assumed to be environmentally induced due to its asymptomatic-nature and occurrence in groundwater relying communities. This study aimed to understand environmental risk-factors underlying CKDu-etiology using Indian sub-district (Canacona) as case-study...
March 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/28290837/-the-choice-of-anticoagulant-therapy-in-patients-with-non-valvular-atrial-fibrillation-and-chronic-kidney-disease
#4
N A Koziolova, E A Polyanskaya, I I Kolegova
The review shows the prevalence of atrial fibrillation (AF) in patients with chronic kidney disease (CKD), depending on the severity of the disease. Patients with non-valvular AF and CKD have a significantly increased risk of both bleeding and thromboembolic complications, and death from all causes. Evaluation of the results of randomized clinical trials (RCTs), meta-analyzes of RCTs demonstrated the advantages of the new oral anticoagulants (NOAC), such as dabigatran, rivaroxaban, apixaban, compared with warfarin in reducing the risk of bleeding in patients with AF and CKD in predialysis stage...
January 2017: Kardiologiia
https://www.readbyqxmd.com/read/28288453/medical-treatment-of-tattoo-complications
#5
Jørgen Serup
Tattooing is a skin trauma and involves a special vulnus punctatum (with inserted tattoo ink, a vulnus venenatum), which should heal with no infection and no local complication. Local treatment in the healing phase ideally builds on the 'moist wound' principle using plastic film, hydrocolloids, silver dressing, and compression. Bacterial infections during healing are treated with oral antibiotics, and a list of first-line antibiotics is proposed. Notice is given to severe infections with affected general condition, and it is emphasized that intravenous antibiotic treatment must be instituted as early as possible to prevent septic shock and death...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28287115/efficient-control-of-chronic-lcmv-infection-by-a-cd4-t-cell-epitope-based-heterologous-prime-boost-vaccination-in-a-murine-model
#6
Ran He, Xinxin Yang, Cheng Liu, Xiangyu Chen, Lin Wang, Minglu Xiao, Jianqiang Ye, Yuzhang Wu, Lilin Ye
CD4(+) T cells are essential for sustaining CD8(+) T cell responses during a chronic infection. The adoptive transfer of virus-specific CD4(+) T cells has been shown to efficiently rescue exhausted CD8(+) T cells. However, the question of whether endogenous virus-specific CD4(+) T cell responses can be enhanced by certain vaccination strategies and subsequently reinvigorate exhausted CD8(+) T cells remains unexplored. In this study, we developed a CD4(+) T cell epitope-based heterologous prime-boost immunization strategy and examined the efficacy of this strategy using a mouse model of chronic lymphocytic choriomeningitis virus (LCMV) infection...
March 13, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28284982/the-balance-between-cd8-t-cell-mediated-clearance-of-aav-encoded-antigen-in-the-liver-and-tolerance-is-dependent-on-the-vector-dose
#7
Sandeep R P Kumar, Brad E Hoffman, Cox Terhorst, Ype P de Jong, Roland W Herzog
The liver continuously receives antigens from circulation and the gastrointestinal tract. A complex immune regulatory system has evolved in order to both limit inflammation and promote tolerance in the liver. Although in situ immune tolerance mechanisms enable successful gene therapy and liver transplantation, at the same time they facilitate chronic infections by pathogens such as hepatitis viruses. It is, however, poorly understood why hepatocytes infected with hepatitis viruses or transduced with adeno-associated virus (AAV)-based vectors may be rejected by CD8(+) T cells several months later...
March 8, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28276697/the-crosstalk-between-sphingomyelinases-and-reactive-oxygen-species-in-mycobacterial-infection
#8
Yuqing Wu, Erich Gulbins, Heike Grassme
SIGNIFICANCE: Tuberculosis (TB), which is caused by Mycobacterium tuberculosis, is one of the most important infections worldwide. The sphingomyelinase/ceramide system, which has been shown to be a crucial factor in internalizing and killing various pathogens, modulates both the pro-inflammatory response and the state of mycobacteria in macrophages. However, studies about the role of sphingomyelinases in TB are still at an early stage. Recent Advances: Recent studies elucidated several roles of sphingomyelinases in manipulating mycobacterial infections...
March 9, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28257810/anti-her2-immunoliposomes-for-co-delivery-of-paclitaxel-and-rapamycin-for-breast-cancer-therapy
#9
Josimar O Eloy, Raquel Petrilli, Deise L Chesca, Fabiano P Saggioro, Robert J Lee, Juliana Maldonado Marchetti
Breast cancer is the second leading cause of cancer deaths among women. Paclitaxel (PTX) is used for its treatment, however non-selectivity, rapid systemic clearance and hypersensitivity to the commercially available formulation are major drawbacks. Rapamycin (RAP), an mTOR inhibitor, acts synergistically with PTX, and thus could be used in combination with it. Drug loading into nanocarriers, particularly liposomes, has proven to enhance efficacy and reduce side-effects of chemotherapeutic drugs. Within this context, the functionalization of liposomes with antibodies for overexpressed receptors on tumor surface is a potential strategy to increase specificity and reduce side-effects...
February 28, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28256042/the-allomap%C3%A2-genomic-biomarker-story-10-years-after
#10
Mario C Deng
Over the last >20 years, we have co-developed the rationale for the first diagnostic and prognostic leukocyte gene expression profiling (GEP) biomarker test in transplantation medicine that gained US-FDA-regulatory clearance and international evidence-based medicine guideline acceptance to rule out moderate/severe acute cellular cardiac allograft rejection without invasive endomyocardial biopsies (EMB). Based on this test, a non-invasive clinical algorithm was implemented since 2005. After clinical implementation, this GEP-based monitoring in direct comparison with an EMB-based strategy was non-inferior with respect to detection of clinical rejection, defined as new onset allograft dysfunction with/without histology of ACR, re-transplantation or death, and at the same time improved patient satisfaction...
March 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28252214/imaging-flow-cytometry-for-multiparametric-analysis-of-molecular-mechanism-involved-in-the-cytotoxicity-of-human-cd8-t-cells
#11
Guido H Wabnitz, Henning Kirchgessner, Yvonne Samstag
The clearance of tumors or virus infected cells is a crucial task of the immune system. Cytotoxic T-cells (CTLs) are able to detect and to kill such altered host cells. Given the recent success of checkpoint inhibitors for tumor therapy, it becomes more and more important to understand the biology of T-cell mediated target cell killing. Tests that allow analyzing the biology of CTLs are either based on flow cytometry or fluorescence microscopy. Thus, they either lack image-based information or have a poor statistical robustness...
March 2, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28244955/plasma-soluble-cd163-is-associated-with-postmortem-brain-pathology-in-human-immunodeficiency-virus-infection
#12
Alex K Bryant, David J Moore, Tricia H Burdo, Jessica R Lakritz, Ben Gouaux, Virawudh Soontornniyomkij, Cristian L Achim, Eliezer Masliah, Igor Grant, Andrew J Levine, Ronald J Ellis
OBJECTIVE: Higher plasma soluble CD163 (sCD163), shed by monocytes and macrophages, correlates with neurocognitive impairment in human immunodeficiency virus (HIV) infection. We hypothesized that higher antemortem plasma or cerebrospinal fluid sCD163 would be associated with greater postmortem neurodegeneration and/or microgliosis. DESIGN: Retrospective, postmortem observational study. METHODS: We measured sCD163 levels in antemortem plasma (n = 54) and cerebrospinal fluid (n = 32) samples from 74 HIV participants (median 5 months before death) who donated their brains to research at autopsy...
February 27, 2017: AIDS
https://www.readbyqxmd.com/read/28244455/epidemiological-and-survival-analysis-of-triple-negative-breast-cancer-cases-in-a-retrospective-multicenter-study
#13
R Sarin, L Khandrika, Rnm Hanitha, A Avula, M Batra, S Kaul, H Raj, S Shivkumar, S Gupta, E Khan, Tps Bhandari, Svss Prasad, V A Reddy, G Swarnalata, M Bakre, S Chatterjee, J Jain
INTRODUCTION: This is a retrospective study with data collected from breast cancer cases from five major Apollo Hospitals across India, as part of a biobanking process. One aspect of our study focused specifically on data from triple-negative breast cancer (TNBC) cases. The aim of this study was to analyze epidemiology, treatment options, and survival of the patients with TNBC. Our goal was to draw conclusions on the preponderance of the disease and also to understand the outcomes using the existing therapy options...
July 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28242423/effect-of-inos-inhibitor-lnmma-along-with-antibiotics-chloramphenicol-or-ofloxacin-in-murine-peritoneal-macrophages-regulates-s-aureus-infection-as-well-as-inflammation-an-in%C3%A2-vitro-study
#14
Somrita Dey, Biswadev Bishayi
Death due to sepsis by S. aureus is rapidly increasing because of their potent weaponries against macrophage mediated killing. Macrophages serve as intracellular reservoirs of S. aureus. Although significant resources have been invested during the last decade in new treatments for sepsis, only antibiotic therapy has failed to improve outcomes. Moreover the host pathogen interaction resulted in host cell death triggering inflammation. So, successful therapy requires amalgamation of therapies to delineate pathogen along with providing protection to host cell...
February 24, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28241314/retinal-pigment-epithelial-cells-suppress-phagolysosome-activation-in-macrophages
#15
Eric Wang, Yoona Choe, Tat Fong Ng, Andrew W Taylor
Purpose: The eye is an immune-privileged microenvironment that has adapted several mechanisms of immune regulation to prevent inflammation. One of these potential mechanisms is retinal pigment epithelial cells (RPE) altering phagocytosis in macrophages. Methods: The conditioned media of RPE eyecups from eyes of healthy mice and mice with experimental autoimmune uveitis (EAU) were used to treat primary macrophage phagocytizing pHrodo bacterial bioparticles. In addition, the neuropeptides were depleted from the conditioned media of healthy RPE eyecups and used to treat phagocytizing macrophages...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28240313/enhancing-lysosomal-biogenesis-and-autophagic-flux-by-activating-the-transcription-factor-eb-protects-against-cadmium-induced-neurotoxicity
#16
Huifeng Pi, Min Li, Li Tian, Zhiqi Yang, Zhengping Yu, Zhou Zhou
Cadmium (Cd), a highly ubiquitous heavy metal, is a well-known inducer of neurotoxicity. However, the mechanism underlying cadmium-induced neurotoxicity remains unclear. In this study, we found that Cd inhibits autophagosome-lysosome fusion and impairs lysosomal function by reducing the levels of lysosomal-associated membrane proteins, inhibiting lysosomal proteolysis and altering lysosomal pH, contributing to defects in autophagic clearance and subsequently leading to nerve cell death. In addition, Cd decreases transcription factor EB (TFEB) expression at both the mRNA and protein levels...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28237876/passive-transfer-of-interferon-%C3%AE-over-expressing-macrophages-enhances-resistance-of-scid-mice-to-mycobacterium-tuberculosis-infection
#17
Rajamouli Pasula, William J Martin, Banu Rekha Kesavalu, Maher Y Abdalla, Bradley E Britigan
Infection with Mycobacterium tuberculosis (M.tb) is associated with increased deaths worldwide. Alveolar macrophages (AMs) play a critical role in host defense against infection with this pathogen. In this work we tested the hypothesis that passive transfer of normal AMs, IFN-γ activated AMs, or macrophages transduced to over-express IFN-γ into the lungs of immunosuppressed SCID mice, where resident macrophages are present but not functional, would enhance alveolar immunity and increase clearance of pulmonary M...
February 23, 2017: Cytokine
https://www.readbyqxmd.com/read/28228465/prognostic-value-of-residual-urine-volume-gfr-by-24-hour-urine-collection-and-egfr-in-patients-receiving-dialysis
#18
Mi Jung Lee, Jung Tak Park, Kyoung Sook Park, Young Eun Kwon, Hyung Jung Oh, Tae-Hyun Yoo, Yong-Lim Kim, Yon Su Kim, Chul Woo Yang, Nam-Ho Kim, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND AND OBJECTIVES: Residual kidney function can be assessed by simply measuring urine volume, calculating GFR using 24-hour urine collection, or estimating GFR using the proposed equation (eGFR). We aimed to investigate the relative prognostic value of these residual kidney function parameters in patients on dialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using the database from a nationwide prospective cohort study, we compared differential implications of the residual kidney function indices in 1946 patients on dialysis at 36 dialysis centers in Korea between August 1, 2008 and December 31, 2014...
March 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28225767/interferon-%C3%AE-1a-for-the-treatment-of-ebola-virus-disease-a-historically-controlled-single-arm-proof-of-concept-trial
#19
Mandy Kader Konde, Darren P Baker, Fode Amara Traore, Mamadou Saliou Sow, Alioune Camara, Alpha Amadou Barry, Doussou Mara, Abdoulaye Barry, Moussa Cone, Ibrahima Kaba, Amento Ablam Richard, Abdoul Habib Beavogui, Stephan Günther, Melania Pintilie, Eleanor N Fish
To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD). Based on our in vitro evidence of antiviral activity of interferon (IFN)-ß activity against Ebola virus, we conducted a single arm clinical study in Guinea to evaluate the safety and therapeutic efficacy of IFN β-1a treatment for EVD. Nine individuals infected with Ebola virus were treated with IFN β-1a and compared retrospectively with a matched cohort of 21 infected patients receiving standardized supportive care only during the same time period at the same treatment unit...
2017: PloS One
https://www.readbyqxmd.com/read/28223796/stromelysin-2-mmp-10-facilitates-clearance-and-moderates-inflammation-and-cell-death-following-lung-exposure-to-long-multiwalled-carbon-nanotubes
#20
Tyler C Vandivort, Timothy P Birkland, Talita P Domiciano, Somenath Mitra, Terrance J Kavanagh, William C Parks
Multiwalled carbon nanotubes (MWCNTs) are nanomaterials composed of multiple layers of graphene cylinders with unique properties that make them valuable for a number of industries. However, rising global production has led to concerns regarding potential occupational exposures to them as raw materials during handling. This is especially true for long MWCNT fibers, whose aspect ratio has been posited to initiate pathology similar to that of asbestos. Matrix metalloproteinases (MMPs) are a class of extracellular endopeptidases that control various processes related to tissue repair, inflammation, and more...
2017: International Journal of Nanomedicine
keyword
keyword
13927
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"