keyword
MENU ▼
Read by QxMD icon Read
search

Microglia

keyword
https://www.readbyqxmd.com/read/29667931/ave0991-a-nonpeptide-analogue-of-ang-1-7-attenuates-aging-related-neuroinflammation
#1
Teng Jiang, Liu-Jun Xue, Yang Yang, Qing-Guang Wang, Xiao Xue, Zhou Ou, Qing Gao, Jian-Quan Shi, Liang Wu, Ying-Dong Zhang
During the aging process, chronic neuroinflammation induced by microglia is detrimental for the brain and contributes to the etiology of several aging-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. As a newly identified axis of renin-angiotensin system, ACE2/Ang-(1-7)/MAS1 axis plays a crucial role in modulating inflammatory responses under various pathological conditions. However, its relationship with aging-related neuroinflammation is less studied so far. In this study, by using SAMP8 mice, an animal model of accelerated aging, we revealed that the neuroinflammation in the aged brain might be attributed to a decreased level of Ang-(1-7)...
April 17, 2018: Aging
https://www.readbyqxmd.com/read/29667667/%C3%AE-cyperone-inhibits-lps-induced-inflammation-in-bv-2-cells-through-activation-of-akt-nrf2-ho-1-and-suppression-of-the-nf-%C3%AE%C2%BAb-pathway
#2
Bingxu Huang, Dewei He, Guangxin Chen, Xin Ran, Wenjin Guo, Xingchi Kan, Wei Wang, Dianfeng Liu, Shoupeng Fu, Juxiong Liu
Accumulating evidence has shown that activated microglia cause inflammatory immune response, which could lead to neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. α-Cyperone, one of the main ingredients of Cyperus rotundus oil, has been reported to possess anti-inflammatory activity in activated macrophages. In this study, we found that α-cyperone markedly decreased the production of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in LPS-induced BV-2 cells...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29666700/oil-palm-phenolics-inhibit-the-in-vitro-aggregation-of-%C3%AE-amyloid-peptide-into-oligomeric-complexes
#3
Robert P Weinberg, Vera V Koledova, Hyeari Shin, Jennifer H Park, Yew Ai Tan, Anthony J Sinskey, Ravigadevi Sambanthamurthi, ChoKyun Rha
Alzheimer's disease is a severe neurodegenerative disease characterized by the aggregation of amyloid- β peptide (A β ) into toxic oligomers which activate microglia and astrocytes causing acute neuroinflammation. Multiple studies show that the soluble oligomers of A β 42 are neurotoxic and proinflammatory, whereas the monomers and insoluble fibrils are relatively nontoxic. We show that A β 42 aggregation is inhibited in vitro by oil palm phenolics (OPP), an aqueous extract from the oil palm tree (Elaeis guineensis) ...
2018: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/29666569/inhibitory-effects-of-betulinic-acid-on-lps-induced-neuroinflammation-involve-m2-microglial-polarization-via-camkk%C3%AE-dependent-ampk-activation
#4
Chuwen Li, Chao Zhang, Hefeng Zhou, Yu Feng, Fan Tang, Maggie P M Hoi, Chengwei He, Dan Ma, Chao Zhao, Simon M Y Lee
In response to the microenvironment, microglia may polarize into either an M1 pro-inflammatory phenotype, exacerbating neurotoxicity, or an M2 anti-inflammatory phenotype, conferring neuroprotection. Betulinic acid (BA) is a naturally pentacyclic triterpenoid with considerable anti-inflammatory properties. Here, we aim to investigate the potential effects of BA on microglial phenotype polarization and to reveal the underlying mechanisms of action. First, we confirmed that BA promoted M2 polarization and inhibited M1 polarization in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29666475/lincrna-cox2-regulates-nlrp3-inflammasome-and-autophagy-mediated-neuroinflammation
#5
Zhenyi Xue, Zimu Zhang, Hongkun Liu, Wen Li, Xiangdong Guo, Zhihui Zhang, Ying Liu, Long Jia, Yan Li, Yinghui Ren, Hongwei Yang, Lijuan Zhang, Qi Zhang, Yurong Da, Junwei Hao, Zhi Yao, Rongxin Zhang
Inflammasome activation plays key roles in host defense, but also contributes to the pathogenesis of auto-inflammatory, and neurodegenerative diseases. As autophagy is connected with both the innate and adaptive immune systems, autophagic dysfunction is also closely related to inflammation, infection, and neurodegeneration. Here we identify that lincRNA-Cox2, previously known as a mediator of both the activation and repression of immune genes expression in innate immune cells, could bind NF-κB p65 and promote its nuclear translocation and transcription, modulating the expression of inflammasome sensor NLRP3 and adaptor ASC...
April 17, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29666403/intact-interleukin-10-receptor-signaling-protects-from-hippocampal-damage-elicited-by-experimental-neurotropic-virus-infection-of-sjl-mice
#6
Ann-Kathrin Uhde, Malgorzata Ciurkiewicz, Vanessa Herder, Muhammad Akram Khan, Niko Hensel, Peter Claus, Michael Beckstette, René Teich, Stefan Floess, Wolfgang Baumgärtner, Klaus Jung, Jochen Huehn, Andreas Beineke
Theiler's murine encephalomyelitis virus (TMEV) infection represents an experimental mouse model to study hippocampal damage induced by neurotropic viruses. IL-10 is a pleiotropic cytokine with profound anti-inflammatory properties, which critically controls immune homeostasis. In order to analyze IL-10R signaling following virus-induced polioencephalitis, SJL mice were intracerebrally infected with TMEV. RNA-based next generation sequencing revealed an up-regulation of Il10, Il10rα and further genes involved in IL-10 downstream signaling, including Jak1, Socs3 and Stat3 in the brain upon infection...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665726/dexmedetomidine-mitigates-microglia-mediated-neuroinflammation-through-up-regulation-of-programmed-cell-death-protein-1-in-a-rat-spinal-cord-injury-model
#7
Hefan He, Yingying Zhou, Yilin Zhou, Jiayuan Zhuang, Xu He, Siyuan Wang, Wenping Lin
Excessive neuroinflammation aggravates neurological damage after spinal cord injury (SCI). Controlling neuroinflammation might favor neuroregeneration and tissue repair. Dexmedetomidine is reported to inhibit post-SCI neuroinflammation in previous research. In the current study, to determine the mechanisms by which dexmedetomidine inhibits neuroinflammation, we tested the effect of dexmedetomidine hydrochloride on microglia in vitro and in a rat SCI model. We found that dexmedetomidine hydrochloride up-regulated programmed cell death protein 1 (PD-1), an immunoregulatory molecule, in activated microglia but not in resting microglia...
April 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29665116/atrophy-and-microglial-distribution-in-primary-progressive-aphasia-with-tdp-43
#8
Garam Kim, Kabriya Bolbolan, Tamar Gefen, Sandra Weintraub, Eileen H Bigio, Emily Rogalski, Marek-Marsel Mesulam, Changiz Geula
OBJECTIVE: To quantitatively determine the density and distribution of activated microglia across cortical regions and hemispheres in the brains of primary progressive aphasia (PPA) participants with pathologic diagnoses of FTLD-TDP, and to examine the relationships between microglial densities, patterns of focal atrophy, TDP-43 inclusions, and clinical phenotype. METHODS: Activated microglia and TDP-43 inclusions were visualized in whole-hemisphere brain sections using immunohistochemical methods from 5 participants with PPA-TDP...
April 17, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29665074/parkin-deficiency-modulates-nlrp3-inflammasome-activation-by-attenuating-an-a20-dependent-negative-feedback-loop
#9
François Mouton-Liger, Thibault Rosazza, Julia Sepulveda-Diaz, Amélie Ieang, Sidi-Mohamed Hassoun, Emilie Claire, Graziella Mangone, Alexis Brice, Patrick P Michel, Jean-Christophe Corvol, Olga Corti
Neuroinflammation and mitochondrial dysfunction, key mechanisms in the pathogenesis of Parkinson's disease (PD), are usually explored independently. Loss-of-function mutations of PARK2 and PARK6, encoding the E3 ubiquitin protein ligase Parkin and the mitochondrial serine/threonine kinase PINK1, account for a large proportion of cases of autosomal recessive early-onset PD. PINK1 and Parkin regulate mitochondrial quality control and have been linked to the modulation of innate immunity pathways. We report here an exacerbation of NLRP3 inflammasome activation by specific inducers in microglia and bone marrow-derived macrophages from Park2-/- and Pink1-/- mice...
April 17, 2018: Glia
https://www.readbyqxmd.com/read/29663649/trem2-inhibits-inflammatory-responses-in-mouse-microglia-by-suppressing-the-pi3k-nf-%C3%AE%C2%BAb-signaling
#10
Caixia Li, Bing Zhao, Caizhao Lin, Zhiping Gong, Xiaoxia An
This study aimed to investigate the effects of triggering receptor expressed on myeloid cell-2 (TREM2) on the production of pro-inflammatory mediators and cytokines induced by lipopolysaccharide (LPS) in BV2 microglia. TREM2 expression or TREM2-specific siRNA were used to induce TREM2 overexpression or silencing. The BV2 cells were pre-treated with the PI3K inhibitor of LY294002 for1 h and stimulated with LPS for 24 h. Then, the cell viability, apoptosis, phagocytosis, nitric oxide (NO), lactate dehydrogenase (LDH) and cytokine production, as well as the activation of AKT and NF-kB were determined, respectively...
April 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29662435/ac2-26-induces-ikk%C3%AE-degradation-through-chaperone-mediated-autophagy-via-hspb1-in-ncm-treated-microglia
#11
Lu Liu, Dandan An, Junying Xu, Bin Shao, Xing Li, Jing Shi
Annexin A1 (ANXA1) is an endogenous protein with potent anti-inflammatory properties in the brain. Although ANXA1 has been predominantly studied for its binding to formyl peptide receptors (FPRs) on plasma membranes, little is known regarding whether this protein has an anti-inflammatory effect in the cytosol. Here, we investigated the mechanism by which the ANXA1 peptide Ac2-26 decreases high TNF-α production and IKKβ activity, which was caused by oxygen glucose deprivation/reperfusion (OGD/R)-induced neuronal conditioned medium (NCM) in microglia...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29662171/fatal-demyelinating-disease-is-induced-by-monocyte-derived-macrophages-in-the-absence-of-tgf-%C3%AE-signaling
#12
Harald Lund, Melanie Pieber, Roham Parsa, David Grommisch, Ewoud Ewing, Lara Kular, Jinming Han, Keying Zhu, Jik Nijssen, Eva Hedlund, Maria Needhamsen, Sabrina Ruhrmann, André Ortlieb Guerreiro-Cacais, Rasmus Berglund, Maria J Forteza, Daniel F J Ketelhuth, Oleg Butovsky, Maja Jagodic, Xing-Mei Zhang, Robert A Harris
The cytokine transforming growth factor-β (TGF-β) regulates the development and homeostasis of several tissue-resident macrophage populations, including microglia. TGF-β is not critical for microglia survival but is required for the maintenance of the microglia-specific homeostatic gene signature1,2 . Under defined host conditions, circulating monocytes can compete for the microglial niche and give rise to long-lived monocyte-derived macrophages residing in the central nervous system (CNS)3-5 . Whether monocytes require TGF-β for colonization of the microglial niche and maintenance of CNS integrity is unknown...
April 16, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29662056/neuronal-sphk1-acetylates-cox2-and-contributes-to-pathogenesis-in-a-model-of-alzheimer-s-disease
#13
Ju Youn Lee, Seung Hoon Han, Min Hee Park, Bosung Baek, Im-Sook Song, Min-Koo Choi, Yoh Takuwa, Hoon Ryu, Seung Hyun Kim, Xingxuan He, Edward H Schuchman, Jae-Sung Bae, Hee Kyung Jin
Although many reports have revealed the importance of defective microglia-mediated amyloid β phagocytosis in Alzheimer's disease (AD), the underlying mechanism remains to be explored. Here we demonstrate that neurons in the brains of patients with AD and AD mice show reduction of sphingosine kinase1 (SphK1), leading to defective microglial phagocytosis and dysfunction of inflammation resolution due to decreased secretion of specialized proresolving mediators (SPMs). Elevation of SphK1 increased SPMs secretion, especially 15-R-Lipoxin A4, by promoting acetylation of serine residue 565 (S565) of cyclooxygenase2 (COX2) using acetyl-CoA, resulting in improvement of AD-like pathology in APP/PS1 mice...
April 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29660975/synergistic-effects-of-psychosocial-stress-and-mild-peripheral-infection-on-inducing-microglial-activation-in-the-hippocampal-dentate-gyrus-and-long-lasting-deficits-in-hippocampus-related-memory
#14
Wen-Yu Tzeng, Chien-Chou Su, Li-Han Sun, Chianfang G. Cherng, Lung Yu
Lipopolysaccharide (LPS) treatment and stress may cause immune activation in the brain, an event which has been thought to play a role in mediating stress-induced cognitive dysfunction. However, the enduring impact of psychosocial stress on brain immune activation or cognitive deficits has not been well investigated. Likewise, it remains unexplored whether there exist synergistic effects of psychosocial stress and a weak systemic LPS treatment on brain immune activation and/or cognitive function. In this work, a 10-day social defeat regimen was used to model psychosocial stress and the number and density of ionized calcium-binding adaptor molecule 1 (Iba1)-stained microglia was used to reveal brain immune activation in male Balb/C mice...
April 17, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29660468/ethyl-acetate-fraction-of-trichilia-catigua-protects-against-oxidative-stress-and-neuroinflammation-after-cerebral-ischemia-reperfusion
#15
Jacqueline Godinho, Anacharis Babeto de Sa-Nakanishi, Lucas Stafuza Moreira, Rúbia Maria Weffort de Oliveira, Claudia Hitomi Huzita, João Carlos P Mello, André Oliveira Fernandes da Silva, Celso Vataru Nakamura, Isolde Santos Previdelli, Matheus Henrique Dal Molin Ribeiro, Humberto Milani
ETHNOPHARMACOLOGICAL RELEVANCE: Trichilia catigua A. Juss (Meliaceae) preparations have been used in folk medicine to alleviate fatigue, stress, and improve memory. Antinociceptive, antiinflammatory, and in vitro neuroprotective effects have been observed in animals. Cerebral ischemia/reperfusion (I/R) leads to severe neuropsychological deficits that are largely associated with oxidative stress, inflammation and neurodegeneration. We reported previously that an ethyl-acetate fraction (EAF) of T...
April 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29660443/cell-to-cell-communication-by-extracellular-vesicles-focus-on-microglia
#16
REVIEW
Rosa C Paolicelli, Giorgio Bergamini, Lawrence Rajendran
Extracellular vesicles, including exosomes and microvesicles, are small, nano-to-micrometer vesicles that are released from cells. While initially observed in immune cells and reticulocytes as vesicles meant to remove archaic proteins, now they have been observed in almost all cell types of multicellular organisms. Growing evidence indicates that extracellular vesicles, containing lipids, proteins and RNAs, represent an efficient way to transfer functional cargoes from one cell to another. In the central nervous system, the extensive cross-talk ongoing between neurons and glia, including microglia, the immune cells of the brain, takes advantage of secreted vesicles, which mediate intercellular communication over long range distance...
April 13, 2018: Neuroscience
https://www.readbyqxmd.com/read/29658944/an-in-vivo-model-of-functional-and-vascularized-human-brain-organoids
#17
Abed AlFatah Mansour, J Tiago Gonçalves, Cooper W Bloyd, Hao Li, Sarah Fernandes, Daphne Quang, Stephen Johnston, Sarah L Parylak, Xin Jin, Fred H Gage
Differentiation of human pluripotent stem cells to small brain-like structures known as brain organoids offers an unprecedented opportunity to model human brain development and disease. To provide a vascularized and functional in vivo model of brain organoids, we established a method for transplanting human brain organoids into the adult mouse brain. Organoid grafts showed progressive neuronal differentiation and maturation, gliogenesis, integration of microglia, and growth of axons to multiple regions of the host brain...
April 16, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29658057/combined-effects-of-rat-schwann-cells-and-17%C3%AE-estradiol-in-a-spinal-cord-injury-model
#18
Zeinab Namjoo, Fateme Moradi, Roya Aryanpour, Abbas Piryaei, Mohammad Taghi Joghataei, Yusef Abbasi, Amir Hosseini, Sajad Hassanzadeh, Fatemeh Ranjbar Taklimie, Cordian Beyer, Adib Zendedel
Spinal cord injury (SCI) is a devastating traumatic event which burdens the affected individuals and the health system. Schwann cell (SC) transplantation is a promising repair strategy after SCI. However, a large number of SCs do not survive following transplantation. Previous studies demonstrated that 17β-estradiol (E2) protects different cell types and reduces tissue damage in SCI experimental animal model. In the current study, we evaluated the protective potential of E2 on SCs in vitro and investigated whether the combination of hormonal and SC therapeutic strategy has a better effect on the outcome after SCI...
April 15, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29656686/lipopolysaccharide-from-rhodobacter-sphaeroides-tlr4-antagonist-attenuates-hypersensitivity-and-modulates-nociceptive-factors
#19
Agnieszka M Jurga, Ewelina Rojewska, Wioletta Makuch, Joanna Mika
CONTEXT: Accumulating evidence has demonstrated that Toll-like receptors (TLRs), especially TLR4 localized on microglia/macrophages, may play a significant role in nociception. OBJECTIVE: We examine the role of TLR4 in a neuropathic pain model. Using behavioural/biochemical methods, we examined the influence of TLR4 antagonist on levels of hypersensitivity and nociceptive factors whose contribution to neuropathy development has been confirmed. MATERIALS AND METHODS: Behavioural (von Frey's/cold plate) tests were performed with Wistar male rats after intrathecal administration of a TLR4 antagonist (LPS-RS ULTRAPURE (LPS-RSU), 20 μG: lipopolysaccharide from Rhodobacter sphaeroides, InvivoGen, San Diego, CA) 16 H and 1 h before chronic constriction injury (cci) to the sciatic nerve and then daily for 7 d...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29656363/2-pentadecyl-2-oxazoline-reduces-neuroinflammatory-environment-in-the-mptp-model-of-parkinson-disease
#20
Marika Cordaro, Rosalba Siracusa, Rosalia Crupi, Daniela Impellizzeri, Alessio Filippo Peritore, Ramona D'Amico, Enrico Gugliandolo, Rosanna Di Paola, Salvatore Cuzzocrea
Current pharmacological management of Parkinson disease (PD) does not provide for disease modification, but addresses only symptomatic features. Here, we explore a new approach to neuroprotection based on the use of 2-pentadecyl-2-oxazoline (PEA-OXA), the oxazoline derivative of the fatty acid amide signaling molecule palmitoylethanolamide (PEA), in an experimental model of PD. Daily oral treatment with PEA-OXA (10 mg/kg) significantly reduced behavioral impairments and neuronal cell degeneration of the dopaminergic tract induced by four intraperitoneal injections of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on 8-week-old male C57 mice...
April 14, 2018: Molecular Neurobiology
keyword
keyword
1392
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"