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https://www.readbyqxmd.com/read/29714649/personalized-therapy-based-on-sequential-molecular-analysis-leads-to-30-months-of-survival-in-a-patient-with-diffuse-unresectable-gastric-linitis-plastica
#1
Linda Mahjoubi, Fabiola Cecchi, Christophe Massard, Fabio Calabro, Anas Gazzah, Rastislav Bahleda, Philippe Jamme, Maximiliano Gelli, Diane Goere, Ludovic Lacroix, Julien Adam, Lukas Heukamp, Patrizia Trenta, Todd Hembrough, Jean-Charles Soria, Cora Sternberg, Michel Ducreux
INTRODUCTION: Diffuse gastric cancer is associated with poor prognosis. We report a patient with metastatic gastric linitis plastica harboring human epidermal growth factor receptor 2 ( HER2) activating mutation and HER2 amplification. CASE DESCRIPTION: The patient received 5-fluorouracil/folinic acid and oxaliplatin combined with trastuzumab/pertuzumab, resulting in disease control for 8 months. Second-line therapy with nivolumab and trastuzumab/pertuzumab was well-tolerated, with macroscopic peritoneal response...
March 1, 2018: Tumori
https://www.readbyqxmd.com/read/29536296/a-randomized-phase-ii-multicenter-trial-to-explore-efficacy-of-weekly-intraperitoneal-in-comparison-with-intravenous-paclitaxel-administered-immediately-after-gastrectomy-to-the-patients-with-high-risk-of-peritoneal-recurrence-final-results-of-the-inpact-trial
#2
Naoto Takahashi, Mitsuro Kanda, Takaki Yoshikawa, Nobuhiro Takiguchi, Kazumasa Fujitani, Katsufumi Miyamoto, Yuichi Ito, Osamu Takayama, Motohiro Imano, Norio Mitsumori, Junichi Sakamoto, Satoshi Morita, Yasuhiro Kodera
BACKGROUND: Intraperitoneal administration of paclitaxel had been considered a promising option to treat peritoneal metastasis, the most frequent pattern of recurrence in gastric cancer after D2 gastrectomy, but its safety and efficacy after gastrectomy had not been fully explored. METHODS: A phase II randomized comparison of postoperative intraperitoneal (IP) vs. intravenous (IV) paclitaxel was conducted. Patients with resectable gastric linitis plastica, cancer with minimal amount of peritoneal deposits (P1), or cancer positive for the peritoneal washing cytology (CY1) were eligible...
March 13, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29484053/mucinous-carcinoma-of-the-gallbladder-with-signet-ring-cells
#3
Takeshi Fukuda, Yoshihiro Sakimoto, Kenichi Narita, Mitsuko Ariizumi, Yoshio Aizawa, Kunihiko Fukuda
Most gallbladder carcinomas are adenocarcinomas, of which mucinous carcinoma (MC) is a rare pathologic subtype. Signet ring cells are seldom found in MCs. We report an extremely rare case of gallbladder MC with signet ring cells. This is the first radiological case report about this rare type of histologic entity with detailed discussion of imaging findings in the English literature. In addition to the features of MC, linitis plastica-like invasion, which is the key feature of signet ring cells, was confirmed by both imaging and histopathologic analysis...
December 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29390283/a-case-report-of-gastric-linitis-plastica-diagnosed-by-endoscopic-ultrasound-guided-fine-needle-aspiration
#4
Shinji Muraoka, Kouhei Tsuchida, Mari Iwasaki, Naoya Izawa, Hidehito Jinnai, Toshinori Komatsubara, Misako Tsunemi, Fumi Sakuma, Ken Kashima, Ko Fukushi, Hideyuki Hiraishi
RATIONALE: There is currently no consensus on the ideal method for obtaining deep tissue biopsy material of advanced gastric LP. EUS-FNA has potential as a useful diagnostic method. Thus, we report the case of a 46-year-old male with advanced gastric linitis plastica (LP) who was diagnosed using endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). PATIENT CONCERNS: The patient underwent esophagogastroduodenoscopy (EGD) because of epigastric pain at a local clinic...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29299363/does-histology-really-influence-gastric-cancer-prognosis
#5
Carrie Luu, Ram Thapa, Katherine Woo, Domenico Coppola, Khaldoun Almhanna, Jose M Pimiento, Dung-Tsa Chen, Daissy Dominguez Marquez, Pamela J Hodul
Background: Gastric cancer (GC) is associated with poor survival despite curative-intent surgical resection and systemic therapy. Our objective is to examine the impact of histology on prognosis as well as the impact of linitis plastica (LP) on survival. Methods: The GC database at a single institution was evaluated for patients who underwent resection from 2000 to 2015. Clinicopathologic characteristics were examined and descriptive statistics was used to analyze four groups of patients based on Lauren classification: intestinal (n=93), diffuse (n=20), diffuse with signet-ring cell features (n=57), and LP (n=40)...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29230262/-cavernous-metastasis-from-blader-tumor
#6
Mohammed Alae Touzani, Othmane Yddoussalah
The incidence of cavernous metastases after radical treatment for bladder tumor is exceptional and is approximately 1%. The mean time between surgery and the occurrence of metastases is 8 months. In some cases they occur after 10 years. Diagnosis is confirmed by biopsy, which shows their urothelial origin. Here we report the case of 56-year old patient, with a history of smoking, having undergone total cystoprostatectomy in January 2017, who presented 2 months later with induratio penis plastica with no other sign associated...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29150634/incomplete-resection-and-linitis-plastica-are-factors-for-poor-survival-after-extended-multiorgan-resection-in-gastric-cancer-patients
#7
Hua Xiao, Min Ma, Yanping Xiao, Yongzhong Ouyang, Ming Tang, Kunyan Zhou, Yuan Hong, Bo Tang, Chaohui Zuo
The aim of this retrospective study was to analyze the morbidity, mortality, and survival rates of extended multiorgan resection (EMR) for locally advanced gastric cancer patients compared to gastrectomy alone and a palliative operation. 893 locally advanced gastric cancer patients without distant metastasis had surgery including gastrectomy alone (GA group, n = 798), EMR resection (EMR group, n = 75), and palliative operation (palliative gastrectomy or gastrojejunostomy (PO group, n = 20)). Postoperative mortality and complication rates in the EMR group were significantly higher than in the GA group (2...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29017220/-bronchitis-plastica-acute-dyspnea-and-branching-airway-casts
#8
P Wischmann, S Keymel, M Kelm, S Krüger
A 65 year old female presented to the emergency department with dyspnea and progressive cough with very viscous elongated secretion plugs. She suffered from multiple cardiac comorbidities and chronic heart failure. The CT scan of the thorax demonstrated extensive pulmonary infiltrates, unspecific mediastinal lymphadenopathy and enlargement of pulmonary lymph vessels. Bronchoscopy was performed and showed extensive occlusive bronchial casts. We diagnosed a case of bronchitis plastica. Therapy with inhalative heparin led to clinical improvement...
October 2017: Pneumologie
https://www.readbyqxmd.com/read/28890816/epidemiological-profile-of-gastric-cancer-in-the-northwestern-region-of-algeria-about-116-cases
#9
Safia Fehim, Racheda Bouhaous, Mustapha Diaf, Amine Mokhtar Drici, Meghit Boumediene Khaled
BACKGROUND: Gastric cancer (GC) remains a public health issue despite the global incidence decrease over the last decades. GC is the third leading cause of cancer-related death worldwide and stills of poor prognosis due to its late detection. The overall objective of our study was to describe the epidemiological, clinical, and histopathological aspects of stomach cancer. However, the specific purpose was to determine the gastric precancerous lesions among patients with histologically confirmed GC admitted at the gastroenterology department of the University Hospital of Sidi-Bel-Abbes city, Algeria...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28809600/linitis-plastica-of-muscle-fascia-presenting-as-tiptoeing-gait
#10
Antoinette O'Connor, Deirdre Kelly, Maria Gaughan, Michael M Maher, Paula O'Leary, Niamh Bermingham, Simon Cronin, Seamus O'Reilly
No abstract text is available yet for this article.
November 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28731489/sexual-health-adherence-to-mediterranean-diet-body-weight-physical-activity-and-mental-state-factors-correlated-to-each-other
#11
Pier A Della Camera, Simone Morselli, Gianmartin Cito, Giovanni Tasso, Andrea Cocci, Nicola Laruccia, Fabrizio Travaglini, Dario Del Fabbro, Antonio R Mottola, Mauro Gacci, Sergio Serni, Marco Carini, Alessandro Natali
INTRODUCTION: Mediterranean diet has shown a protective role against cardiovascular disease, diabetes, cancer onset, microvascular damage and dementia in many trials. Our purpose is the assessment of a correlation between physical activity, Mediterranean diet, body mass index (BMI), depression and erection disorder (ED). METHODS: After having signed disclaimer to the study participation, we administered the IIEF 15 questionnaire (International Index of Erectil Function), the Hamilton questionnaire for major depression, the Med-Diet Questionnaire, the Ipaq Questionnaire (International Index of Physical Activity) to 245 patients and calculated the BMI...
October 25, 2017: Urologia
https://www.readbyqxmd.com/read/28679451/the-significance-of-a-nineteenth-century-definition-in-the-era-of-genomics-linitis-plastica
#12
REVIEW
Annamaria Agnes, Jeannelyn S Estrella, Brian Badgwell
BACKGROUND: Linitis plastica due to gastric adenocarcinoma is a condition with a long history, but still lacks a standardized definition and is commonly confused with Borrmann type IV, Lauren diffuse, and signet-cell type gastric cancer. The absence of a clear definition is a problem when investigating its biological characteristics and role as a possible independent factor for prognosis. Nevertheless, the biological behavior for linitis plastica, which is unique, may be valuable in risk stratification and have implications for treatment...
July 5, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28664424/diagnostic-staging-laparoscopy-in-gastric-cancer-a-prospective-cohort-at-a-cancer-institute-in-japan
#13
Tomoyuki Irino, Takeshi Sano, Naoki Hiki, Manabu Ohashi, Souya Nunobe, Koshi Kumagai, Satoshi Ida, Toshiharu Yamaguchi
BACKGROUND: There have been many studies that describe the value of diagnostic staging laparoscopy (DSL) in gastric cancer. However, different studies use different indications, making study results difficult to compare. This study aimed to clarify the diagnostic feasibility of DSL for gastric cancer in a prospective manner and investigated the impact of DSL on clinical decision-making in gastric cancer treatment. METHODS: The study was a prospective cohort study based at a single institution between January 2010 and December 2013...
January 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/28647380/-lymphedema-of-the-lower-limbs-initial-manifestation-of-gastric-linitis-plastica
#14
S Nguyen, D Ouvrier, D Massalou, P Viau, A Chevallier, S Patouraux, T Passeron, J-P Lacour, H Montaudié
BACKGROUND: Primary lymphedemas are constitutional abnormalities of the lymphatic system. Secondary lymphedemas occur after damage to the lymphatic system, mainly after cancer treatments or tumour mass compression. There are many other causes, including filariasis, which is nonetheless very rare in France. PATIENTS AND METHODS: A 52-year-old man presented with a two-month history of increased size of the left leg. He was asymptomatic and in good general condition...
June 21, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28643144/evaluation-of-the-american-joint-committee-on-cancer-8th-edition-staging-system-for-gastric-cancer-patients-after-preoperative-therapy
#15
Naruhiko Ikoma, Mariela Blum, Jeannelyn S Estrella, Prajnan Das, Wayne L Hofstetter, Keith F Fournier, Paul Mansfield, Jaffer A Ajani, Brian D Badgwell
BACKGROUND: The American Joint Committee on Cancer (AJCC) recently released its 8th edition staging system, which created a separate staging system for gastric cancer patients who have undergone preoperative therapy (ypStage). The objective of this retrospective study was to apply the new ypStage to patients who have undergone preoperative therapy and potentially curative gastrectomy. METHODS: We collected data from a prospectively maintained institutional database of gastric cancer patients who underwent potentially curative gastrectomy after preoperative therapy (1995-2015)...
January 2018: Gastric Cancer
https://www.readbyqxmd.com/read/28609263/image-diagnosis-a-gastric-signet-ring-adenocarcinoma-of-type-linitis-plastica-mimicking-splenomegaly-in-a-patient-with-chronic-lymphocytic-leukemia
#16
Leonid L Yavorkovsky, Shazia Ali
No abstract text is available yet for this article.
2017: Permanente Journal
https://www.readbyqxmd.com/read/28489207/conversion-of-plastic-surgery-meeting-abstract-presentations-to-full-manuscripts-a-brazilian-perspective
#17
Rafael Denadai, André Silveira Pinho, Hugo Samartine, Rodrigo Denadai, Cassio Eduardo Raposo-Amaral
Objective: to assess the conversion rate of Plastic Surgery meeting abstract presentations to full manuscript publications and examine factors associated with this conversion. Methods: we assessed the abstracts presented at the 47th and 48th Brazilian Congresses of Plastic Surgery by cross-referencing with multiple databases. We analyzed the Abstracts' characteristics associated with full manuscript publications. Results: of the 200 abstracts presented, 50 abstracts were subsequently published in full, giving the conference a conversion rate of 25%...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28489206/lower-extremity-reconstruction-epidemiology-management-and-outcomes-of-patients-of-the-federal-district-north-wing-regional-hospital
#18
Jefferson Lessa Soares Macedo, Simone Corrêa Rosa, Daniel Lobo Botelho, Clendes Pereira Dos Santos, Murilo Neves DE Queiroz, Tabatha Gonçalves Andrade Castelo Branco Gomes
Objective: to evaluate the management of lower limbs complex traumatic injuries by analyzing their characteristics, types, conduct and evolution, with emphasis on surgical treatment. Methods: we conducted a prospective study of patients treated by Plastic Surgery at a regional hospital of the Federal District during a one-year period. We collected data through serial evaluations and telephone contact records. Results: we studied 40 patients, with a mean age of 25...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28487617/endoscopic-ultrasound-guided-cutting-of-holes-and-deep-biopsy-for-diagnosis-of-gastric-infiltrative-tumors-and-gastrointestinal-submucosal-tumors-using-a-novel-vertical-diathermic-loop
#19
Yu-Mei Liu, Xiu-Jiang Yang
AIM: To report on a more accurate diagnostic possibility offered by endoscopic ultrasound-guided cutting of holes and deep biopsy (EUS-CHDB) for pathologic diagnosis of gastric infiltrative tumors and gastrointestinal submucosal tumors. METHODS: Ten consecutive patients who were suspected of having gastric invasive tumors or gastrointestinal submucosal tumors underwent EUS-CHDB with a novel vertical diathermic loop. We reviewed their medical data and analysed the effectiveness and safety of this new method...
April 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28300963/foot-length-measurements-of-newborns-of-high-and-low-risk-pregnancies
#20
Ana Karina Marques Salge, Érika Lopes Rocha, Maria Aparecida Munhoz Gaíva, Thaíla Correa Castral, Janaína Valadares Guimarães, Raphaela Maioni Xavier
OBJECTIVE: Comparing foot length measurements of newborns in high and low risk pregnancies at a public hospital in Goiânia, GO, Brazil. METHOD: A cross-sectional study carried out between April, 2013 and May, 2015, with a sample consisting of 180 newborns; 106 infants of women from high-risk pregnancies and 74 of women from low-risk pregnancies. Data were descriptively analyzed. Foot length measurement was performed using a stiff transparent plastic ruler, graduated in millimeters...
March 9, 2017: Revista da Escola de Enfermagem da U S P
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