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Biagio Ricciuti, Giulia Costanza Leonardi, Noemi Ravaioli, Andrea De Giglio, Marta Brambilla, Enrico Prosperi, Franca Ribacchi, Marialuisa Meacci, Lucio Crinò, Daniele Maiettini, Rita Chiari, Giulio Metro
Breast cancer metastases to the gastrointestinal tract are very rare occurrences. Among the histological subtypes of breast cancer, invasive lobular carcinomas have a high capacity of metastasis to uncommon sites including the stomach. Conversely, there has not been sufficient evidence supporting the gastric metastasis of invasive ductal carcinoma. Herein, we report a unique case of metastatic ductal breast carcinoma mimicking primary linitis plastica in a male patient, particularly focusing on the clinical and pathological features of presentation...
September 2016: Journal of Breast Cancer
E J Jongerius, D Boerma, K A Seldenrijk, S L Meijer, J J G Scheepers, F Smedts, S M Lagarde, O Balague Ponz, M I van Berge Henegouwen, J W van Sandick, S S Gisbertz
BACKGROUND: A complete omentectomy is recommended as part of radical (sub)total gastrectomy for gastric cancer, but there is little evidence to suggest any survival benefit. The aim of this study was to evaluate the incidence of, and risk factors for, metastases in the greater omentum in patients undergoing gastrectomy for gastric cancer. METHODS: This was a multicentre prospective cohort study (OMEGA trial) of consecutive patients with gastric cancer undergoing (sub)total gastrectomy with complete en bloc omentectomy and modified D2 lymphadenectomy...
October 2016: British Journal of Surgery
Kyoungwon Jung, Moo In Park, Sung Eun Kim, Seun Ja Park
Early diagnosis of Borrmann type 4 advanced gastric cancer (AGC) is very important for improving the prognosis of AGC patients. Because there is no definite mass in most cases of Borrmann type 4 AGC, its accurate diagnosis via endoscopy requires an understanding of its pathogenesis and developmental process. Moreover, many people confuse linitis plastica (LP) type gastric cancer (GC), scirrhous GC, and Borrmann type 4 AGC. To distinguish each of these cancers, knowledge of their endoscopic and pathological differences is necessary, especially for LP type GCs in the developmental stage...
July 2016: Clinical Endoscopy
Filip Wn Haenen, Ben Gys, Tom Moreels, Maartje Michielsen, Tobie Gys, Thierry Lafullarde
Laparoscopic Roux-en-Y gastric bypass (RYGB) is currently the preferred surgical procedure to treat morbid obesity. It has proven its effects on excess weight loss and its positive effect on comorbidities. One of the main issues, however, is the postoperative evaluation of the bypassed gastric remnant. In literature, cancer of the excluded stomach after RYGB is rare. We describe the case of a 52-year-old woman with gastric linitis plastica in the bypassed stomach after Roux-en-Y gastric bypass, diagnosed by means of laparoscopy and Single-Balloon enteroscopy, and it's clinical importance...
June 3, 2016: Acta Chirurgica Belgica
Naruhiko Ikoma, Mariela Blum, Yi-Ju Chiang, Jeannelyn S Estrella, Sinchita Roy-Chowdhuri, Keith Fournier, Paul Mansfield, Jaffer A Ajani, Brian D Badgwell
BACKGROUND: This study aimed to identify the yield of staging laparoscopy with peritoneal lavage cytology for gastric cancer patients and to track it over time. METHODS: The medical records of patients with gastric or gastroesophageal adenocarcinoma who underwent pretreatment staging laparoscopy at the authors' institution from 1995 to 2012 were reviewed. The yield of laparoscopy was defined as the proportion of patients who had positive findings on laparoscopy, including those with macroscopic carcinomatosis, positive cytology, or other clinically important findings...
July 6, 2016: Annals of Surgical Oncology
Naueen Akbar Chaudhry, Kamran Zahid, Roxana Coman, Qing Zhang
A 52-year-old Caucasian woman presented with progressive nausea and vomiting, weight loss, and burning epigastric and chest pain. Initial oesophagogastroduodenoscopy (OGD) with biopsies demonstrated gastritis in absence of Helicobacter pylori A gastric emptying study, CT scan with pancreatic protocol and a colonoscopy revealed no concerning findings. Calcium channel blockers and proton pump inhibitors offered little improvement. A high-resolution oesophageal impedance manometry was performed, which was significant for jackhammer oesophagus with maximum distal contractile index 11 052 mm Hg-s-cm...
2016: BMJ Case Reports
Serap Kaya, Mahmut Gumus, Yesim Gurbuz, Devrim Cabuk, Ozgur Acikgoz, Suleyman Temiz, Kazim Uygun
AIM: The aim of this study is to evaluate the prognostic value of β-catenin and LEF-1 expression in patients with operable gastric cancer that receive adjuvant treatment and the relationship between demographic and histopathological variables. MATERIAL AND METHOD: In this study, 82 gastric cancer patients treated with adjuvant treatment after surgery and followed in the Medical Oncology Department of Kocaeli University were included. β-catenin and LEF-1 expression were examined by immunuhistochemical analysis in paraffin embedded tumor tissues of the patients...
2016: American Journal of Translational Research
Liu Yu, Ke Chen, Ying Xu, Shubei Wang, Qianqian Liu, Qiao Ye, Tingjun Ye, Yunwei Sun
Endoscopic ultrasound (EUS) and EUS-guided fine-needle aspiration (EUS-FNA) have a great value in clinical practice of gastrointestinal lymphoma (GIL). Auxiliary methods such as flow cytometry (FCM) and gene rearrangement provide additional information for the diagnosis. Current study aims to explore the diagnostic value of EUS-FNA combined with FCM and gene rearrangement for GIL in our single institution. Suspected GIL cases, which were referred to EUS, FNA, FCM, or gene rearrangement examination, were retrospectively reviewed from January 2011 to May 2014...
May 3, 2016: Hematological Oncology
X F Xu, W Yang, X J Zhang, W J Xie
No abstract text is available yet for this article.
March 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Shivani Garg, Ramzi Mulki, Daniel Sher
Metastatic disease from pancreatic carcinoma involving the stomach is an unusual event, and the pattern of spread in the form of linitis plastica, to our knowledge, has not been reported previously. Local recurrence after curative resection for pancreatic cancer is the most common pattern of disease. We report a case of metastatic pancreatic adenocarcinoma presenting as linitis plastica of the stomach 4 years after curative resection. A 52-year-old man presented with epigastric pain and melaena 4 years after undergoing a Whipple's procedure for a poorly-differentiated pancreatic adenocarcinoma, stage IB; T2N0M0...
2016: BMJ Case Reports
Asma Ouakaa-Kchaou, Norsaf Bibani, Héla Elloumi, Dorra Trad, Asma Kochlef, Dalila Gargouri, Jamel Kharrat, Raouf Cherif
No abstract text is available yet for this article.
October 2015: La Tunisie Médicale
Yasuhiro Kodera, Naoto Takahashi, Takaki Yoshikawa, Nobuhiro Takiguchi, Kazumasa Fujitani, Yuichi Ito, Katsufumi Miyamoto, Osamu Takayama, Motohiro Imano, Daisuke Kobayashi, Yumi Miyashita, Satoshi Morita, Junichi Sakamoto
BACKGROUND: Peritoneal carcinomatosis is common after curative resection of gastric cancer. Intraperitoneal administration of paclitaxel (PTX) is known to control ovarian peritoneal metastases. PATIENTS AND METHODS: Patients with either linitis plastica or T4 cancer with high risk of peritoneal metastasis or recurrence but whose cancer was considered resectable were preregistered. After their cancer had been confirmed intraoperatively as resectable, the patients were randomized into either group A (PTX at 60 mg/m(2) intraperitoneally on the day of surgery and on days 14, 21, 28, 42, 49, and 56) or group B (PTX at 80 mg/m(2) administered intravenously by the identical schedule) before being treated by evidence-based chemotherapy...
February 15, 2016: Gastric Cancer
Clemence Burgain, Adeline Germain, Claire Bastien, Xavier Orry, Laurence Choné, Michel Claudon, Valérie Laurent
PURPOSE: To analyze the features of gastrointestinal linitis plastica obtained by computed tomography (CT). MATERIALS AND METHODS: We conducted a single-center, retrospective analysis of 45 cases of gastrointestinal tract linitis plastica collected over a 10-year period. "Linitis plastica" was defined based on histological characteristics. Primary and secondary linitis plastica were included. Two readers independently assessed the radiological findings (i.e., number of lesions, mass, wall thickening, and enhancement)...
July 2016: Abdominal Radiology
Yasumichi Yagi, Shozo Sasaki, Akemi Yoshikawa, Yuji Tsukioka, Wataru Fukushima, Takashi Fujimura, Hisashi Hirosawa, Ryohei Izumi, Katsuhiko Saito
Metastases to the gastrointestinal tract rarely occur in breast cancer except in invasive lobular carcinoma. The present study reports a rare case of metastatic gastric cancer from invasive ductal carcinoma (IDC) of the breast mimicking primary gastric linitis plastica. A 51-year-old premenopausal female, who had a history of partial mastectomy for right breast cancer at the age of 40, was referred to Toyama City Hospital (Toyoma, Japan) for an endoscopic diagnosis of gastric linitis plastica. Abdominal computed tomography (CT) revealed left hydronephrosis, while peritoneal metastasis and malignant ascites were not detected...
December 2015: Oncology Letters
Sijil Kottikkal Sivaraman, Premaletha Sunil, K R V Kumar
No abstract text is available yet for this article.
April 2015: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
Aaron U Blackham, Doug S Swords, Edward A Levine, Nora F Fino, Malcolm H Squires, George Poultsides, Ryan C Fields, Mark Bloomston, Sharon M Weber, Timothy M Pawlik, Linda X Jin, Gaya Spolverato, Carl Schmidt, David Worhunsky, Clifford S Cho, Shishir K Maithel, Konstantinos I Votanopoulos
BACKGROUND: Current staging and treatment guidelines for gastric adenocarcinoma do not differentiate between linitis plastic (LP) and non-LP cancers. Significant controversy exists regarding the surgical management of LP patients. METHODS: Using the multi-institutional U.S. Gastric Cancer Collaborative database, 869 gastric cancer patients who underwent resection between 2000 and 2012 were identified. Clinicopathologic and outcomes data of 58 LP patients were compared to 811 non-LP patients...
April 2016: Annals of Surgical Oncology
K S Rachan Shetty, Vasu Reddy Challa, K C Lakshmaiah, G Champaka, K Govind Babu
Though breast cancer is a common cancer it rarely metastasizes to stomach. Lobular carcinoma is the most common histological type which presents with gastric metastases. The most common presentation is linitis plastica. Here, we would like to report two cases of invasive ductal breast cancer who presented with gastric metastases. One case presented as linitis plastica and the other as nodular growth. Both were given palliative chemotherapy and both responded partially. One patient was succumbed to death in 6 months and the other patient is surviving 7 months after diagnosis of gastric metastases...
July 2015: Journal of Cancer Research and Therapeutics
K Muehlenberg, O Dietl, P Piso, O Pech
Differential diagnostic aspects of colon stenoses are discussed using the example case of a female patient presenting with multilocular colon metastases, who had lobular breast cancer 9 years previously. Typical is linitis plastica, which can indicate tumorous infiltration not only of the stomach, but also of the large intestine. Other endoscopic imaging and histological studies may, however, fail. The pathologist requires the anamnestic data relating to the breast cancer for exact assignment of the tumorous infiltration...
October 2015: Der Internist
Jihane Boustani, Stefano Kim, Nicolas Lescut, Zaher Lakkis, Marjolaine de Billy, Francine Arbez-Gindre, Marine Jary, Christophe Borg, Jean-François Bosset
BACKGROUND: Rectal linitis plastica (RLP) is a rare disease with poor outcome. It is often accompanied by a delayed histopathological diagnosis, primarily due to submucosal disease. A concentric ring pattern or "target sign" on T2-weighted magnetic resonance imaging (MRI) has been proposed as being characteristic for early suspicion. Even though RLP is more aggressive and has poorer survival than other rectal adenocarcinomas, no specific treatment is recommended. In this case report of 3 patients, we challenge the sensitivity of the characteristic radiological pattern, and we review the existing data for a treatment strategy...
2015: American Journal of Case Reports
Stephanie A Dean, Benjamin Mathis, Leslie A Litzky, Ian C Hood
A 33-year-old female collapsed and died suddenly after presenting with acute dyspnea and increasing cough over the preceding several months. Autopsy revealed poorly differentiated linitis plastica adenocarcinoma of the stomach. Microscopic examination of the lungs showed features consistent with pulmonary tumor thrombotic microangiopathy (PTTM). PTTM is a well-described complication in patients with adenocarcinoma. The typical presentation involves acute pulmonary hypertension, right-sided heart failure, and sudden death, often before the adenocarcinoma is discovered...
November 2015: Journal of Forensic Sciences
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