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Murat Atabey Özer, Nihat Polat, Serkan Özen, Hakan Parlakpınar, Kemal Ekici, Alaaddin Polat, Nigar Vardı, Kevser Tanbek, Azibe Yildiz
PURPOSE: To determine the role of Molsidomine in preventing radiation-induced retinopathy after head and neck region irradiation of rats with a single radiation dose of 15 Gy. MATERIALS AND METHODS: Male Wistar albino rats were randomly grouped into five as follows: (1) control group rats, which were applied through an intraperitoneal (i.p.) vehicle without radiotherapy (RT); (2) RT group rats received a single dose of 15 Gy irradiation and after daily 0.1 ml vehicle i...
November 29, 2016: Current Eye Research
Chen Li, Zhongjie Yan, Xuhua Cao, Xiaowei Zhang, Liang Yang
Relapse is the main cause of mortality in patients with glioblastoma multiforme (GBM). Treatment options involve surgical resection followed by a combination of radiotheraphy and chemotherapy with temozolomide. Several genes and genetic pathways have been identified to contribute to therapeutic resistance, giving rise to recurrence of the malignancy. In the last decades, glioma stem cells (GSCs) with the capacity of self-renewal have been demonstrated to maintain tumor propagation and treatment resistance. Here, we isolated CD133-positive (CD133+) and CD133-negative (CD133-) cells from glioblastoma U98G and U87MG cell lines...
October 2016: Journal of Molecular Neuroscience: MN
Xiaoyan Li, Hui Yang, Huayan Xu, Shasha Wang, Hongjun Gao
BACKGROUND AND OBJECTIVE: One of the most often distance metastasis site of non-small cell lung cancer (NSCLC) is brain and the standard treatment of brain metastasis was radiotheraphy including whole brain irradiation (WBI) and stereotactic radiotherapy (SRT). It has been reported that epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) had the active response in brain metastasis of lung cancer. In the present study, we reported one case of EGFR 19el in cerebrospinal fluid tested by ARMS got partial response given erlotinib...
January 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Yeo-Jin Choi, Ga-Young Baek, Hae-Ran Park, Sung-Kee Jo, Uhee Jung
The control of radioresistance and metastatic potential of surviving cancer cells is important for improving cancer eradication by radiotheraphy. The distal-less homeobox2 (DLX2) gene encodes for a homeobox transcription factor involved in morphogenesis and its deregulation was found in human solid tumors and hematologic malignancies. Here we investigated the role of DLX2 in association with radiation-induced epithelial to mesenchymal transition (EMT) and stem cell-like properties and its regulation by Smad2/3 signaling in irradiated A549 and MDA-MB-231 human cancer cell lines...
2016: PloS One
Basri Cakiroglu, Seyit Erkan Eyyupoglu, Akif Nuri Dogan, Umit Noseri, Suleyman Hilmi Aksoy, Ahmet Bekir Ozturk
Primary testicular lymphoma, is a rare testis tumor that accounts for only less than 9% of all testis tumors. In the preoperative period, it is extremely difficult to distinguish this tumor from other testis tumors. Its diagnosis is done by histological analysis. Most commonly encountered histological type is diffuse large Bcell lymphoma. Adjuvant radiotheraphy and/or chemotheraphy is given after orchiectomy. Prognosis is worse than other testis tumors. Non-metastatic tumors indicates good prognosis within one year...
January 14, 2016: Archivio Italiano di Urologia, Andrologia
T Nakashima, R Yasumatsu, S Toh, K Hashimoto, M Shinoto, K Nakamura, S Komune
OBJECTIVE: To determine the clinical effect of post-operative radiotheraphy and systemic chemotherapy for the treatment of salivary duct carcinoma. STUDY DESIGN: Retrospective review. DESIGN: The medical records of 26 patients treated by surgery with or without radiotheraphy and/or systemic chemotherapy for salivary duct carcinoma were retrospectively reviewed to investigate the role of post-operative adjuvant treatment for the patients' prognosis...
March 2015: Journal of Laryngology and Otology
Zhaohua Gong, Ying Zhang, Hongjin Chu, Peiwen Lian, Liangming Zhang, Ping Sun, Jian Chen
Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painless priapism. On admission to Yantai Yuhuangding Hospital Affiliated to Qingdao University (Yantai, China), examination revealed an erect penis, enlarged lymph nodes in the bilateral inguinal and swelling in the thighs...
November 2014: Oncology Letters
Onur Yaman, Nail Ozdemir, Ismail Ertan Sevin, Füsun Demirçivi Ozer, Saime Unlüoğlu
Primary spinal epidural Hodgkin's lymphoma is very rare. We will discuss the clinical features and treatment of primary spinal epidural Hodgkin's lymphoma. In this paper, a 30-year-old male patient who presented with spinal epidural tumor at the T9-11 level is reported. Subtotal resection of the tumor was performed and the histological examination of the tumor specimen revealed Hodgkin's lymphoma. All other examinations were negative for an occult disease. Six courses of chemotheraphy containing adriamycin, bleomycin, vinblastine and dacarbazine were given to the patient...
2013: Journal of Surgical Case Reports
Kai Liu, Yanyan Han, Binlin Ma
OBJECTIVE: To retrospectively analyze the long-term curative effects and prognostic factors of 137 cases of NPC patients treated with intensity modulated radiation therapy. METHOD: The three-dimensional conformal intensity modulated radiation therapy adopted for the design plan of 137 cases of newly diagnosed and no distant metastatic NPC patients. Evaluation of short-term clinical efficacy was made according to the efficacy evaluation criteria of WHO solid tumor one month after radiotherapy...
November 2013: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Sanjeev Mohanty, L Somu, M Gopinath
Sinonasal teratocarcinoma is a rare tumour of the paranasal sinuses. It was earlier termed as teratoid carcinosarcoma or teratocarcinoma. It is a highly aggressive tumour with a 5 year survival rate of 45 %. Here we report a case of sinonasal teratocarcinoma who was managed excision of tumour by lateral rhinotomy approach followed by radiotheraphy.
June 2013: Indian Journal of Surgery
Linda Bojmar, Elin Karlsson, Sander Ellegård, Hans Olsson, Bergthor Björnsson, Olof Hallböök, Marie Larsson, Olle Stål, Per Sandström
The role of the epithelial-mesenchymal transition (EMT) in cancer has been studied extensively in vitro, but involvement of the EMT in tumorigenesis in vivo is largely unknown. We investigated the potential of microRNAs as clinical markers and analyzed participation of the EMT-associated microRNA-200-ZEB-E-cadherin pathway in cancer progression. Expression of the microRNA-200 family was quantified by real-time RT-PCR analysis of fresh-frozen and microdissected formalin-fixed paraffin-embedded primary colorectal tumors, normal colon mucosa, and matched liver metastases...
2013: PloS One
H Badakhshi, D Kaul, J Nadobny, B Wille, J Sehouli, V Budach
OBJECTIVE: To test the feasibility of volumetric modulated arc therapy (VMAT) in breast cancer and to compare it with three-dimensional conformal radiotherapy (3D-CRT) as conventional tangential field radiotheraphy (conTFRT). METHODS: 12 patients (Stage I, 8: 6 left breast cancer and 2 right breast cancer; Stage II, 4: 2 on each side). Three plans were calculated for each case after breast-conserving surgery. Breast was treated with 50 Gy in four patients with supraclavicular lymph node inclusion, and in eight patients without the node inclusion...
December 2013: British Journal of Radiology
Baris Kilicaslan, Gonul Demir Piskin, Ibrahim Susam, Huseyin Dursun, Oner Ozdogan
We evaluated the effect of radiotherapy (RT) on the elastic properties of the aorta using echocardiography in patients with breast cancer (BC). A total of 105 women with left-sided epidermal growth factor receptor 2 (erb-2) BC were divided into 2 groups, group 1 with patients who did not receive RT and group 2 with patients who received RT. In all patients, echocardiographic examination and serum high-sensitivity C-reactive protein (hs-CRP) levels were determined. A significant decrease in aortic distensibility (AD) and increase in hs-CRP were seen from group 1 to group 2...
August 2014: Angiology
Jalal Hussein, Teck Soon Tan, Aun Wee Chong, Prepageran Narayanan, Rahmat Omar
Choanal stenosis is a well recognized late complication of radiotherapy for nasopharyngeal carcinoma. However velopharyngeal stenosis post radiotherapy for nasopharyngeal carcinoma is rare. We present here a case of bilateral choanal stenosis and velopharyngeal stenosis in a patient treated with radiotherapy for nasopharyngeal carcinoma. A 58-year-old woman presented to our otolaryngology clinic with a one year history of nasal obstruction. She was diagnosed to have nasopharyngeal carcinoma 12 years ago for which she received radiotherapy...
June 2013: Auris, Nasus, Larynx
Tetsunori Shimono, Kichiro Koshida, Hidekazu Nambu, Kosuke Matsubara, Hiroshi Takahashi, Hiroshi Okuda
Ionization chambers are the instruments of choice for use in photon dosimetry. Ionization chambers together with radiographic films represent the best detectors for measurement of dose distribution for a quality assurance (QA) program in intensity-modulated radiotheraphy (IMRT). The polarity effect was investigated for seven different commercially available ionization chambers. This study concentrated on measuring the dependence of the polarity effect at various energies, and for various field size, ionization chamber, and electrometer combinations...
January 2009: Radiological Physics and Technology
Nurettin Cem Sönmez, Burhan Coşkun, Serdar Arisan, Soner Güney, Ayhan Dalkiliç
Metastatic involement of penis is an exceptionally rare condition. 77% of the metastases are originated from the pelvic region; prostate and bladder are the most frequent primary locations. Retrograde venous route, retrograde lymphatic route, arterial spread, direct extension, implantation and secondary to instrumentation are the mechanisms of metastasis. Approximately two thirds of all penile metastasis are detected at a mean time of 18 months after the detection of the primary tumor and the remaining one third is presented at the same time with primary tumor...
2009: Cases Journal
Radosław Rózycki, Aleksandra Jakubaszek, Artur Maliborski
PURPOSE: Analysis of causes of epiphora in patients which have been examined in Department of Ophthalmology in Military Institute of Health Service from 2004 to 2007. MATERIAL AND METHODS: The study has comprised 330 subjects: 241 women and 89 men (mean age 58.85 +/- 19.93 years). All patients have been examined because of epiphora (eyelid and lacrimal punctum position, medial canthal tendon laxity--horizontal resting position, lateral distraction test, fluorescein dye disappearance test, syringing of the upper and lower canaliculus, dacryocystography and/or lacrimal scintigraphy)...
2009: Klinika Oczna
Sulen Sarioglu, Cagdas Acara, Fadime Can Akman, Nihal Dag, Cenk Ecevit, Ahmet Omer Ikiz, Oguz H Cetinayak, Emel Ada
Tumor budding is recognized as an adverse prognostic factor for a few carcinoma types. We evaluated the importance of this finding in 64 laryngeal carcinoma patients treated with surgery and radiotheraphy, with a median follow up of 53 (6-181) months. Budding was determined by re-evaluating hematoxylin-eosin (H&E) stained tumor sections, and classified as mild, moderate, and marked. Budding was not identified in 14 (21.88%) cases. Mild, moderate, and marked budding was observed in 21 (32.81%), 15 (23.44%), and 14 (21...
February 15, 2010: Pathology, Research and Practice
J M Garbizu, O Mateo-Sierra, J M Pérez-Calvo, B Iza, F Ruiz-Juretschke
Radiation induced tumors are well-known but rare complications of radiotherapy. Meningiomas are the most common radiation-induced (RI) cranial tumors, followed by gliomas and sarcomas, while other tumors as haemangioblastomas remain extremely exceptional. We present 7 patients with RI brain tumors diagnosed and treated at our institution between 1990 and 2006. Retrospective review of their clinical charts is supplied. All patients were irradiated during childhood as a treatment for another disease, and fulfilled the criteria of RI neoplasia...
August 2008: Neurocirugía
Mar Jiménez de la Peña, Vicente Martínez de Vega Fernández, Manuel Recio Rodríguez, Javier Carrascoso Arranz, Luis Herráiz Hidalgo, Elena Alvarez Moreno
Imaging has become an important adjunct to the clinical assessment of uterine cancer, specially magnetic resonance imaging (MRI) studies. In cervical cancer, the two areas in which MRI is superior to other diagnostic imaging modalities are local diseases staging and evaluation for local recurrence. MRI is an integral part in staging the primary tumour, monitoring responce to treatment, detecting complications and recurrence, and in planning radiotheraphy. MRI has a crucial role in the development of fertility-sparing surgery in young women with cervical cancer...
September 2008: Gynecologic Oncology
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