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https://www.readbyqxmd.com/read/29236358/in-vivo-imaging-the-motility-of-monocyte-macrophage-during-inflammation-in-diabetic-mice
#1
Rui Shi, Wei Feng, Chao Zhang, Tingting Yu, Zhan Fan, Zheng Liu, Zhihong Zhang, Dan Zhu
Diabetes, as a chronic metabolic disease, can impair the immune function of monocytes/macrophages (MMs). However, it is unclear how MMs immune response to inflammation with the development of diabetes, and whether immune response around the inflammatory foci depends on the depth in tissue. Footpad provides a classical physiological site for monitoring cellular behavior during inflammation, but limited to the superficial dermis due to the strong scattering of footpad. Herein, we used confocal microscopy to monitor the motility of MMs in deeper tissue around inflammatory foci with the development of type 1 diabetic (T1D) mice through a swithable footpad skin optical clearing window...
December 13, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29236232/%C3%AE-1%C3%A2-6-d-glucan-secreted-during-the-optimised-production-of-exopolysaccharides-by-paecilomyces-variotii-has-immunostimulatory-activity
#2
Erica F Osaku, Rafael A Menolli, Claudia R L de M Costa, Fernando Henrique G Tessaro, Renan H de Melo, Alex E do Amaral, Péricles A D Duarte, Arquimedes Paixão de Santana Filho, Andrea Caroline Ruthes, José Luis da C Silva, Rosiane G Mello
Paecilomyces variotii is a filamentous fungus that occurs worldwide in soil and decaying vegetation. Optimization of the fermentation process for exopolysaccharide (EPS) production from the fungus P. variotii, structure determination and immuno-stimulating activity of EPS were performed. Response surface methodology (RSM) coupled with central composite design (CCD) was used to optimize the physical and chemical factors required to produce EPS in submerged fermentation. Preliminary investigations to choose the three factors for the present work were made using a factorial experimental design...
December 13, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29236151/the-effects-of-hap-and-macrophage-cells-to-the-expression-of-inflammatory-factors-and-apoptosis-in-hk-2-cells-of-vitro-co-cultured-system
#3
Junchuan Yu, Yaoliang Deng, Zhiwei Tao, Weixia Liang, Xiaofeng Guan, Jihua Wu, Xin Ning, Yunlong Liu, Quan Liu, Ziqi He
This study developed an in vitro system by co-culturing HK-2 cells with different concentration of hydroxyapatite (HAP) and/or macrophage cells to simulate the internal environment of urolithiasis as far as possible, investigating the regulatory effects of macrophage cells on HAP-induced expression of relative inflammatory factors of HK-2 cells. The control group (H group) was only comprised of HK-2 cells. Experimental groups included co-culturing HK-2 cells and macrophage cells (H + M group), co-culturing HK-2 cells and HAP (H + A group), co-culturing macrophage cells and HAP (M + A group), and co-culturing HK-2 cells and macrophage cells with HAP (H + M + A group)...
December 13, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29236056/the-potential-of-frog-skin-derived-peptides-for-development-into-therapeutically-valuable-immunomodulatory-agents
#4
REVIEW
Jelena M Pantic, Ivan P Jovanovic, Gordana D Radosavljevic, Nebojsa N Arsenijevic, J Michael Conlon, Miodrag L Lukic
The aim of this article is to review the immunoregulatory actions of frog skin-derived peptides in order to assess their potential as candidates for immunomodulatory or anti-inflammatory therapy. Frog skin peptides with demonstrable immunomodulatory properties have been isolated from skin secretions of a range of species belonging to the families Alytidae, Ascaphidae, Discoglossidae, Leptodactylidae, Pipidae and Ranidae. Their effects upon production of inflammatory and immunoregulatory cytokines by target cells have been evaluated ex vivo and effects upon cytokine expression and immune cell activity have been studied in vivo by flow cytometry after injection into mice...
December 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29235978/rigid-amphipathic-fusion-inhibitors-demonstrate-antiviral-activity-against-african-swine-fever-virus
#5
Astghik Hakobyan, Inmaculada Galindo, Almudena Nañez, Erik Arabyan, Zaven Karalyan, Alexey A Chistov, Philipp P Streshnev, Vladimir A Korshun, Covadonga Alonso, Hovakim Zakaryan
Rigid amphipathic fusion inhibitors (RAFIs) are a family of nucleoside derivatives that inhibit the infectivity of several enveloped viruses by interacting with virion envelope lipids and inhibiting fusion between viral and cellular membranes. Here we tested the antiviral activity of two RAFIs, 5-(Perylen-3-ylethynyl)-arabino-uridine (aUY11) and 5-(Perylen-3-ylethynyl)uracil-1-acetic acid (cm1UY11) against African swine fever virus (ASFV), for which no effective vaccine is available. Both compounds displayed a potent, dose-dependent inhibitory effect on ASFV infection in Vero cells...
December 13, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29235541/biodegradable-bisvinyl-sulfonemethyl-crosslinked-gelatin-conduit-promotes-regeneration-after-peripheral-nerve-injury-in-adult-rats
#6
Chien-Hsin Ko, Ming-You Shie, Jia-Horng Lin, Yi-Wen Chen, Chun-Hsu Yao, Yueh-Sheng Chen
In our previous study, we found that gelatin-based materials exhibit good conductivity and are non-cytotoxic. In this study, gelatin was cross-linked with bisvinyl sulfonemethyl (BVSM) to fabricate a biodegradable conduit for peripheral nerve repair. First, BVSM on the prepared conduit was characterized to determine its mechanical properties and contact angle. The maximum tensile strength and water contact angle of the gelatin-BVSM conduits were 23 ± 4.8 MPa and 74.7 ± 9°, which provided sufficient mechanical strength to resist muscular contraction; additionally, the surface was hydrophilic...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235509/in-vivo-metabolic-imaging-of-traumatic-brain-injury
#7
Caroline Guglielmetti, Austin Chou, Karen Krukowski, Chloe Najac, Xi Feng, Lara-Kirstie Riparip, Susanna Rosi, Myriam M Chaumeil
Complex alterations in cerebral energetic metabolism arise after traumatic brain injury (TBI). To date, methods allowing for metabolic evaluation are highly invasive, limiting our understanding of metabolic impairments associated with TBI pathogenesis. We investigated whether 13C MRSI of hyperpolarized (HP) [1-13C] pyruvate, a non-invasive metabolic imaging method, could detect metabolic changes in controlled cortical injury (CCI) mice (n = 57). Our results show that HP [1-13C] lactate-to-pyruvate ratios were increased in the injured cortex at acute (12/24 hours) and sub-acute (7 days) time points after injury, in line with decreased pyruvate dehydrogenase (PDH) activity, suggesting impairment of the oxidative phosphorylation pathway...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235277/-targets-identification-and-mechanism-analysis-for-macrophage-activation-of-low-molecular-weight-saccharides-from-cistanche-deserticola-based-on-molecular-affinity-chromatography
#8
Li-Chao Wang, Dan Liu, Yong Jiang, Peng-Fei Tu, Ke-Wu Zeng
This study aims to investigate the targets and targets-involved mechanism for the macrophage activation of low molecular weight saccharides from Cistanche deserticola (LMSC). The phagocytic activity and NO release of RAW264.7 cells were detected, and results showed that LMSC exerts immune activation effect by significantly increasing the phagocytic activity and NO release. LMSC-conjugated epoxy-activated sepharose beads were prepared as affinity reagent to capture the target proteins. Twenty-four proteins such as Eef2 were identified by LC-MS/MS analysis...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29235265/synthesis-of-%C3%AE-branched-acyclic-nucleoside-phosphonates-as-potential-inhibitors-of-bacterial-adenylate-cyclases
#9
Jan Frydrych, Jan Skácel, Markéta Šmídková, Helena Mertlíková-Kaiserová, Martin Dračínský, Ramachandran Gnanasekaran, Martin Lepšík, Monica Soto-Velasquez, Val J Watts, Zlatko Janeba
Inhibition of Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema factor (EF), the key virulence factors with adenylate cyclase (AC) activity, represents a potential method how to treat or prevent toxemia related to whooping cough and anthrax, respectively. A novel series of α-branched acyclic nucleoside phosphonates (ANPs) having a hemiaminal ether moiety was synthesized as potential inhibitors of bacterial adenylate cyclases. ANPs prepared as bisamidates were not cytotoxic but did not exhibited any profound activity (IC50 > 10 µM) towards ACT in J774A...
December 13, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29235197/superoxide-dismutase-from-helicobacter-pylori-suppresses-the-production-of-pro-inflammatory-cytokines-during-in-vivo-infection
#10
Andrew Stent, Alison L Every, Yok T Chionh, Garrett Z Ng, Philip Sutton
BACKGROUND: Helicobacter pylori has undergone considerable adaptation to allow chronic persistence within the gastric environment. While H. pylori-associated diseases are driven by an excessive inflammation, severe gastritis is detrimental to colonization by this pathogen. Hence, H. pylori has developed strategies to minimize the severity of gastritis it triggers in its host. Superoxide dismutase (SOD) is well known for its role in protecting against oxidative attack; less recognized is its ability to inhibit immunity, shown for SOD from mammalian sources and those of some bacterial species...
December 13, 2017: Helicobacter
https://www.readbyqxmd.com/read/29235119/v-set-and-ig-domain-containing-4-vsig4-expressing-hepatic-f4-80-cells-regulate-oral-antigen-specific-responses-in-mouse
#11
Wonhwa Shin, Youkyoung Jeon, Inhak Choi, Yeon-Jeong Kim
Oral tolerance can prevent unnecessary immune responses against dietary antigens. Members of the B7 protein family play critical roles in the positive and/or negative regulation of T cell responses to interactions between APCs and T cells. V-set and Ig domain-containing 4 (VSIG4), a B7-related co-signaling molecule, has been known to act as a co-inhibitory ligand and may be critical in establishing immune tolerance. Therefore, we investigated the regulation of VSIG4 signaling in a food allergy and experimental oral tolerance murine models...
December 13, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29235086/endothelial-expression-of-c-kit-and-cd68-in-dental-follicles-of-human-impacted-third-molars
#12
Mugurel Constantin Rusu, Aliona Rașcu, Mihai Dragomir Stoenescu
Periodontal tissue remnants of odontogenesis constitute the dental follicle (DF) which is actually considered a stem niche in adults. However, potentialities of local endothelia within this niche seem overlooked. We thus aimed at testing the endothelial cells expression of c-kit, the progenitor cells marker, and CD68, commonly regarded as a monocyte/macrophage marker, in human DFs. We performed an immunohistochemical study using these two markers which were applied on samples collected from ten adult patients...
December 13, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29234949/curc-mpeg454-a-pegylated-curcumin-derivative-improves-anti-inflammatory-and-antioxidant-activities-a-comparative-study
#13
Fei Cheng, Yuhe Chen, Zhu Zhan, Yu Liu, Peng Hu, Hong Ren, Huadong Tang, Mingli Peng
We previously demonstrated that a PEGylated curcumin (Curc-mPEG454) significantly inhibited cyclooxygenase 2 (COX-2) expression and improved the progression of liver fibrosis. The current study systematically evaluates its anti-inflammatory and antioxidant activities in vitro in a comparative study with curcumin, aspirin, NS-398, and vitamin C. RAW264.7 murine macrophages were pretreated with Curc-mPEG454, curcumin, aspirin, NS-398, or vitamin C at the indicated concentration for 2 h; then, the cells were stimulated with 1 μg/mL lipopolysaccharide (LPS) for 24 h...
December 13, 2017: Inflammation
https://www.readbyqxmd.com/read/29234825/bindarit-attenuates-pain-and-cancer-related-inflammation-by-influencing-myeloid-cells-in-a-model-of-bone-cancer
#14
Shenghou Liu, Hongwei Gao, Chunzheng Gao, Wenguang Liu, Deguo Xing
C-C motif chemokine ligand 2 (CCL2) is a small cytokine that functions in inflammation and cancer development. Bindarit, a CCL2 inhibitor, is a small anti-inflammatory molecule proven safe by phase II trials in type 2 diabetic nephropathy patients. As cancer-related inflammation is a cause of pain, we investigated whether Bindarit suppresses cancer-related inflammation and pain. We established a bone-cancer mouse model by inoculating cancer cells. After applying Bindarit, we preformed pain sensitivity tests and checked cancer development by X-ray...
December 12, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29234752/morphological-and-immunophenotypical-differences-between-chronic-periodontitis-and-peri-implantitis-a-cross-sectional-study
#15
Pablo Galindo-Moreno, Jesús López-Martínez, Mercedes Caba-Molina, Rosa Ríos-Pelegrina, Laura Torrecillas-Martínez, Alberto Monje, Francisco Mesa, Natalia Chueca, Federico García-García, Francisco O'Valle
PURPOSE: To examine differences in morphology and in immunophenotype subsets between chronic periodontitis (CP) and peri-implantitis (P-I) lesions and to test the diagnostic agreement (CP vs P-I) among three independent observers, based on histopathological features. MATERIALS AND METHODS: This observational cross-sectional study included 15 gingival biopsies of CP lesions and 15 biopsies of P-I lesions for double-blinded examination by three independent pathologists...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29234575/involvement-of-two-uptake-mechanisms-of-gold-and-iron-oxide-nanoparticles-in-a-co-exposure-scenario-using-mouse-macrophages
#16
Dimitri Vanhecke, Dagmar A Kuhn, Dorleta Jimenez de Aberasturi, Sandor Balog, Ana Milosevic, Dominic Urban, Diana Peckys, Niels de Jonge, Wolfgang J Parak, Alke Petri-Fink, Barbara Rothen-Rutishauser
Little is known about the simultaneous uptake of different engineered nanoparticle types, as it can be expected in our daily life. In order to test such co-exposure effects, murine macrophages (J774A.1 cell line) were incubated with gold (AuNPs) and iron oxide nanoparticles (FeO x NPs) either alone or combined. Environmental scanning electron microscopy revealed that single NPs of both types bound within minutes on the cell surface but with a distinctive difference between FeO x NPs and AuNPs. Uptake analysis studies based on laser scanning microscopy, transmission electron microscopy, and inductively coupled plasma optical emission spectrometry revealed intracellular appearance of both NP types in all exposure scenarios and a time-dependent increase...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29234441/euphorbia-kansui-attenuates-insulin-resistance-in-obese-human-subjects-and-high-fat-diet-induced-obese-mice
#17
Seung-Wook Lee, Hyun-Young Na, Mi Hyeon Seol, Mia Kim, Byung-Cheol Lee
Background: Obesity is a main cause of insulin resistance (IR), metabolic syndrome, and fatty liver diseases. This study evaluated Euphorbia kansui radix (Euphorbia) as a potential treatment option for obesity and obesity-induced IR in obese human and high-fat diet- (HFD-) induced obese mice. Methods: In the human study, we analyzed the body weight change of 14 patients who took a single dose of 6 g of Euphorbia powder. In the animal study, male mice were divided into three groups: normal chow, HFD, and Euphorbia (high-fat diet and 100 mg/Kg Euphorbia once per week)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234405/qingchang-wenzhong-decoction-attenuates-dss-induced-colitis-in-rats-by-reducing-inflammation-and-improving-intestinal-barrier-function-via-upregulating-the-msp-ron-signalling-pathway
#18
Tangyou Mao, Junxiang Li, Lijuan Liu, Weihan Zhao, Yuyue Liu, Kangli Gao, Yi Guo, Tianhong Xie, Ningfei Li, Rui Shi
Ulcerative colitis (UC) is a chronic, nonspecific, inflammatory disease for which an effective treatment is lacking. Our previous study found that Qingchang Wenzhong Decoction (QCWZD) can significantly improve the clinical symptoms of UC and ameliorate dextran sulphate sodium- (DSS-) induced ulcerative colitis in rats by downregulating the IP10/CXCR3 axis-mediated inflammatory response. The purpose of the present study was to further explore the mechanism of QCWZD for UC in rats models, which were established by 7-day administration of 4...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234366/antioxidant-and-anti-inflammatory-effects-of-herbal-formula-sc-e3-in-lipopolysaccharide-stimulated-raw-264-7-macrophages
#19
Soo Chil Lee, Young-Won Kwon, Ju-Yeon Park, Sung Yun Park, Ju-Hee Lee, Sun-Dong Park
SC-E3 is a novel herbal formula composed of five oriental medicinal herbs that are used to treat a wide range of inflammatory diseases in Korean traditional medicine. In this study, we sought to determine the effects of SC-E3 on free radical generation and inflammatory response in lipopolysaccharide- (LPS-) treated RAW 264.7 macrophages and the molecular mechanism involved. The ethanol extract of SC-E3 showed good free radical scavenging activity and inhibited LPS-induced reactive oxygen species generation...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234328/forward-and-reverse-signaling-mediated-by-transmembrane-tumor-necrosis-factor-alpha-and-tnf-receptor-2-potential-roles-in-an-immunosuppressive-tumor-microenvironment
#20
REVIEW
Yang Qu, Gang Zhao, Hui Li
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine produced mainly by activated macrophages, lymphocytes and other cell types. Two distinct forms of TNF-α have been identified: soluble TNF-α (sTNF-α) and transmembrane TNF-α (mTNF-α). mTNF-α, which is the precursor of sTNF-α, can be cleaved by the TNF-α converting enzyme (TACE) and is released as sTNF-α. sTNF-α binds primarily to TNF receptor 1 (TNFR1) and plays an important role in the inflammatory immune response, whereas mTNF-α interacts primarily with TNF receptor 2 (TNFR2) and mediates the promotion of cellular proliferation and survival and other biological effects...
2017: Frontiers in Immunology
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