keyword
https://read.qxmd.com/read/38532928/intelligent-structure-prediction-and-visualization-analysis-of-non-coding-rna-in-osteosarcoma-research
#21
Longhao Chen, Liuji He, Baijie Liu, Yinghua Zhou, Lijiang Lv, Zhiguang Wang
BACKGROUND: Osteosarcoma (OS) is the most common bone malignant tumor in children and adolescents. Recent research indicates that non-coding RNAs (ncRNAs) have been associated with OS occurrence and development, with significant progress made in this field. However, there is no intelligent structure prediction and literature visualization analysis in this research field. From the perspective of intelligent knowledge structure construction and bibliometrics, this study will comprehensively review the role of countries, institutions, journals, authors, literature citation relationships and subject keywords in the field of ncRNAs in OS...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38532697/identifying-the-best-candidate-for-primary-tumor-resection-in-patients-with-advanced-osteosarcoma
#22
JOURNAL ARTICLE
Zhengjiang Li, Xingyao Yang, Shuxing Xing
OBJECTIVES: Not all patients with stage III and IV osteosarcoma who undergo surgery to remove the primary tumor will benefit from surgery; therefore, we developed a nomogram model to test the hypothesis that only a subset of patients will benefit from surgery. METHODS: 412 patients were screened from the Surveillance, Epidemiology and End Results (SEER) database. Subsequently, 1:1 propensity score matching (PSM) was used to screen and balance confounders. We first made the hypothesis that patients who underwent the procedure would benefit more...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38532587/-incidence-of-postoperative-complications-in-chinese-patients-with-gastric-or-colorectal-cancer-based-on-a-national-multicenter-prospective-cohort-study
#23
JOURNAL ARTICLE
S Q Zhang, Z Q Wu, B W Huo, H N Xu, K Zhao, C Q Jing, F L Liu, J Yu, Z R Li, J Zhang, L Zang, H K Hao, C H Zheng, Y Li, L Fan, H Huang, P Liang, B Wu, J M Zhu, Z J Niu, L H Zhu, W Song, J You, S Yan, Z Y Li
Objective: To investigate the incidence of postoperative complications in Chinese patients with gastric or colorectal cancer, and to evaluate the risk factors for postoperative complications. Methods: This was a national, multicenter, prospective, registry-based, cohort study of data obtained from the database of the Prevalence of Abdominal Complications After Gastro- enterological Surgery (PACAGE) study sponsored by the China Gastrointestinal Cancer Surgical Union. The PACAGE database prospectively collected general demographic characteristics, protocols for perioperative treatment, and variables associated with postoperative complications in patients treated for gastric or colorectal cancer in 20 medical centers from December 2018 to December 2020...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532575/long-term-outcome-of-peripheral-t-cell-lymphomas-ten-year-follow-up-of-the-international-prospective-t-cell-project
#24
JOURNAL ARTICLE
M Civallero, J G Schroers-Martin, S Horwitz, M Manni, Y Stepanishyna, M E Cabrera, J Vose, M Spina, F Hitz, A Nagler, S Montoto, C Chiattone, T Skrypets, M A Perez Saenz, G Priolo, S Luminari, A Lymboussaki, A Pavlovsky, D Marino, M Liberati, J Trotman, D Mannina, M Federico, R Advani
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of haematological cancers with generally poor clinical outcomes. However, a subset of patients experience durable disease control, and little is known regarding long-term outcomes. The International T-cell Lymphoma Project (ITCLP) is the largest prospectively collected cohort of patients with PTCLs, providing insight into clinical outcomes at academic medical centres globally. We performed a long-term outcome analysis on patients from the ITCLP with available 10-year follow-up data (n = 735)...
March 26, 2024: British Journal of Haematology
https://read.qxmd.com/read/38532489/real-world-association-between-systemic-corticosteroid-exposure-and-complications-in-us-patients-with-severe-asthma
#25
JOURNAL ARTICLE
Thomas B Casale, Thomas Corbridge, Guillaume Germain, François Laliberté, Sean D MacKnight, Julien Boudreau, Mei S Duh, Arijita Deb
BACKGROUND: Systemic corticosteroid (SCS) use remains widespread among patients with severe asthma, despite associated complications. OBJECTIVE: Evaluate the association between cumulative SCS exposure and SCS-related complications in severe asthma. METHODS: This retrospective, longitudinal study used claims data from the Optum Clinformatics Data Mart database (GSK ID: 214469). Eligible patients (≥ 12 years old) had an asthma diagnosis and were divided into two cohorts: SCS use and non/burst-SCS use...
March 26, 2024: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/38532446/correction-a-glutamine-tug-of-war-between-cancer-and-immune-cells-recent-advances-in-unraveling-the-ongoing-battle
#26
Bolin Wang, Jinli Pei, Shengnan Xu, Jie Liu, Jinming Yu
No abstract text is available yet for this article.
March 26, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38532439/bispecific-aptamer-decorated-and-light-triggered-nanoparticles-targeting-tumor-and-stromal-cells-in-breast-cancer-derived-organoids-implications-for-precision-phototherapies
#27
JOURNAL ARTICLE
Simona Camorani, Alessandra Caliendo, Elena Morrone, Lisa Agnello, Matteo Martini, Monica Cantile, Margherita Cerrone, Antonella Zannetti, Massimo La Deda, Monica Fedele, Loredana Ricciardi, Laura Cerchia
BACKGROUND: Based on the established role of cancer-stroma cross-talk in tumor growth, progression and chemoresistance, targeting interactions between tumor cells and their stroma provides new therapeutic approaches. Dual-targeted nanotherapeutics selectively acting on both tumor and stromal cells may overcome the limits of tumor cell-targeting single-ligand nanomedicine due to the complexity of the tumor microenvironment. METHODS: Gold-core/silica-shell nanoparticles embedding a water-soluble iridium(III) complex as photosensitizer and luminescent probe (Iren -AuSiO2 _COOH) were efficiently decorated with amino-terminated EGFR (CL4) and PDGFRβ (Gint4...
March 26, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38532236/primary-closure-versus-vertical-rectus-abdominis-myocutaneous-vram-flap-closure-of-perineal-wound-following-abdominoperineal-resection-a-systematic-review-and-meta-analysis
#28
REVIEW
Hugo C Temperley, Poorya Shokuhi, Niall J O'Sullivan, Benjamin Mac Curtain, Caitlin Waters, Alannah Murray, Christina E Buckley, Maeve O'Neill, Brian Mehigan, Paul H McCormick, Michael E Kelly, John O Larkin
PURPOSE/AIM: Perianal wound healing and/or complications are common following abdominoperineal resection (APR). Although primary closure is commonly undertaken, myocutaneous flap closure such as vertical rectus abdominis myocutaneous flap (VRAM) is thought to improve wound healing process and outcome. A comprehensive meta-analysis was performed to compare outcomes of primary closure versus VRAM flap closure of perineal wound following APR. METHODS: PubMed, MEDLINE, EMBASE, and Cochrane Central Registry of Controlled Trials were comprehensively searched until the 8th of August 2023...
March 27, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38532153/dynamic-treatment-strategy-of-chinese-medicine-for-metastatic-colorectal-cancer-based-on-machine-learning-algorithm
#29
JOURNAL ARTICLE
Yu-Ying Xu, Qiu-Yan Li, Dan-Hui Yi, Yue Chen, Jia-Wei Zhai, Tong Zhang, Ling-Yun Sun, Yu-Fei Yang
OBJECTIVE: To establish the dynamic treatment strategy of Chinese medicine (CM) for metastatic colorectal cancer (mCRC) by machine learning algorithm, in order to provide a reference for the selection of CM treatment strategies for mCRC. METHODS: From the outpatient cases of mCRC in the Department of Oncology at Xiyuan Hospital, China Academy of Chinese Medical Sciences, 197 cases that met the inclusion criteria were screened. According to different CM intervention strategies, the patients were divided into 3 groups: CM treatment alone, equal emphasis on Chinese and Western medicine treatment (CM combined with local treatment of tumors, oral chemotherapy, or targeted drugs), and CM assisted Western medicine treatment (CM combined with intravenous regimen of Western medicine)...
March 27, 2024: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/38532150/exploring-the-combined-anti-cancer-effects-of-sodium-butyrate-and-celastrol-in-glioblastoma-cell-lines-a-novel-therapeutic-approach
#30
JOURNAL ARTICLE
Bahar Kartal, Farika Nur Denizler-Ebiri, Mustafa Güven, Filiz Taşpınar, Hande Canpınar, Sedat Çetin, Tuğçe Karaduman, Serkan Küççüktürk, Javier Castresana, Mehmet Taşpınar
Glioblastoma, a highly aggressive and lethal brain cancer, lacks effective treatment options and has a poor prognosis. In our study, we explored the potential anti-cancer effects of sodium butyrate (SB) and celastrol (CEL) in two glioblastoma cell lines. SB, a histone deacetylase inhibitor, and CEL, derived from the tripterygium wilfordii plant, act as mTOR and proteasome inhibitors. Both can cross the blood-brain barrier, and they exhibit chemo- and radiosensitive properties in various cancer models. GB cell lines LN-405 and T98G were treated with SB and CEL...
March 26, 2024: Medical Oncology
https://read.qxmd.com/read/38532133/digital-twins-in-medicine
#31
REVIEW
R Laubenbacher, B Mehrad, I Shmulevich, N Trayanova
Medical digital twins, which are potentially vital for personalized medicine, have become a recent focus in medical research. Here we present an overview of the state of the art in medical digital twin development, especially in oncology and cardiology, where it is most advanced. We discuss major challenges, such as data integration and privacy, and provide an outlook on future advancements. Emphasizing the importance of this technology in healthcare, we highlight the potential for substantial improvements in patient-specific treatments and diagnostics...
March 2024: Nature computational science
https://read.qxmd.com/read/38532121/symptom-burden-and-relief-in-palliative-care-units-of-german-comprehensive-cancer-center-and-other-hospitals
#32
JOURNAL ARTICLE
Julia Berendt, Sarah Brunner, Maria Heckel, Mitra Tewes, Christoph Ostgathe, Susanne Gahr
PURPOSE: The National Hospice and Palliative Registry contains patient data from German hospice and palliative care facilities about symptoms. The aim of the study at hand is to differentiate symptom burden of patients in palliative care units between Comprehensive Cancer Center (CCC) and other hospitals regarding symptom burden and relief of patients in palliative care units. METHODS: The registry analysis provided data of patients in palliative care units (2014-2018)...
March 27, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38531232/staging-laparoscopy-in-gastric-cancer-patients-from-a-dutch-nationwide-delphi-consensus-towards-a-standardized-protocol
#33
JOURNAL ARTICLE
Karen van der Sluis, Niels A D Guchelaar, Lianne Triemstra, Ron H J Mathijssen, Jelle P Ruurda, Bas P L Wijnhoven, Johanna W van Sandick
BACKGROUND: Staging laparoscopy is a common diagnostic tool in gastric cancer, but its performance varies widely. The aim of this study was to gain Dutch nationwide consensus regarding the indications for and execution of staging laparoscopy in patients with gastric cancer. METHODS: All surgeons in the Netherlands specialized in gastric cancer surgery (n = 52) were asked to participate in a Delphi consensus study. The study involved an initial questionnaire with a 3-point Likert scale, an online consensus meeting, and a second questionnaire using a 2-point Likert scale (agree/disagree)...
March 19, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38531231/long-term-outcomes-of-endoscopic-therapy-versus-surgical-resection-for-2-5%C3%A2-cm-gastric-gastrointestinal-stromal-tumors-a-population-based-comparative-study
#34
JOURNAL ARTICLE
Yixia Chai, Bitao Lin, Jun Zhong, Xiaosheng Wu, Xin Lin, Xiaoyue Ge, Jiayi Jiang, Zhenye Liang, Side Liu, Chuncai Gu
BACKGROUND: Endoscopic therapy (ET) of gastrointestinal stromal tumors (GIST) has become a viable treatment. We intended to compare long-term outcomes of ET versus surgical resection for 2-5 cm GIST using the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: A multicenter retrospective study was conducted to compare the long-term outcomes of patients treated with ET and surgical resection for GIST. The multivariate Cox proportional hazards models were used to identify predictors for patients survival...
March 15, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38531009/knuckleheads
#35
JOURNAL ARTICLE
Timothy D Gilligan
Partnering with patients who reject our recommended treatment: how to understand what our patients are going through.
March 26, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38531002/randomized-double-blind-phase-iii-study-of-pazopanib-versus-placebo-in-patients-with-metastatic-renal-cell-carcinoma-who-have-no-evidence-of-disease-after-metastasectomy-ecog-acrin-e2810
#36
JOURNAL ARTICLE
Leonard J Appleman, Se Eun Kim, Wayne B Harris, Sumanta K Pal, Michael R Pins, Jill Kolesar, Neeraj Agarwal, Rahul A Parikh, Daniel A Vaena, Christopher W Ryan, Mehmood Hashmi, Brian A Costello, David Cella, Janice P Dutcher, Robert S DiPaola, Naomi B Haas, Lynne I Wagner, Michael A Carducci
PURPOSE: Patients with no evidence of disease (NED) after metastasectomy for renal cell carcinoma are at high risk of recurrence. Pazopanib is an inhibitor of vascular endothelial growth factor receptor and other kinases that improves progression-free survival in patients with metastatic RCC (mRCC). We conducted a randomized, double-blind, placebo-controlled multicenter study to test whether pazopanib would improve disease-free survival (DFS) in patients with mRCC rendered NED after metastasectomy...
March 26, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38531001/international-prognostic-score-for-nodular-lymphocyte-predominant-hodgkin-lymphoma
#37
JOURNAL ARTICLE
Michael Sargent Binkley, Jamie E Flerlage, Kerry J Savage, Saad Akhtar, Raphael Steiner, Xiao-Yin Zhang, Michael Dickinson, Anca Prica, Ajay Major, Peter G Hendrickson, David Hopkins, Andrea Ng, Carla Casulo, Jonathan Baron, Kenneth B Roberts, Jalila Al Kendi, Alex Balogh, Umberto Ricardi, Pallawi Torka, Lena Specht, Ravindu De Silva, Keir Pickard, Lindsay J Blazin, Michael Henry, Christine M Smith, Daniel Halperin, Jessica Brady, Bernadette Brennan, Maria Anatolevna Senchenko, Marie Reeves, Bradford S Hoppe, Stephanie Terezakis, Dipti Talaulikar, Marco Picardi, Youlia Kirova, Paige Fergusson, Eliza A Hawkes, Denise Lee, Nicole Wong Doo, Allison Barraclough, Chan Y Cheah, Matthew Ku, Nada Hamad, Howard Mutsando, Michael Gilbertson, Tamara Marconi, Nicholas Viiala, Matthew J Maurer, Dennis A Eichenauer, Richard T Hoppe
PURPOSE: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and large international cooperative efforts are needed to evaluate the significance of clinical risk factors and immunoarchitectural patterns (IAPs) for all stages of pediatric and adult patients with NLPHL. METHODS: Thirty-eight institutions participated in the Global nLPHL One Working Group retrospective study of NLPHL cases from 1992 to 2021. We measured progression-free survival (PFS), overall survival (OS), transformation rate, and lymphoma-specific death rate...
March 26, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38530998/failing-forward-in-peripheral-t-cell-lymphoma
#38
EDITORIAL
Neha Mehta-Shah, Steven M Horwitz
No abstract text is available yet for this article.
March 26, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38530598/challenges-in-obtaining-and-seeking-information-among-breast-cancer-survivors-in-an-asian-country-a-qualitative-study
#39
JOURNAL ARTICLE
Izzati Yussof, Noraida Mohamed Shah, Nur Fa'izah Ab Muin, Sarahfarina Abd Rahim, Ernieda Hatah, Nor Asyikin Mohd Tahir, Kavinash Loganathan, Murallitharan Munisamy
Breast cancer survivors on adjuvant endocrine therapy (AET) have distinct information-seeking experience compared to those in the diagnosis and intensive treatment phase. This study aimed to understand the challenges in obtaining and seeking information among Malaysian breast cancer survivors. We conducted semi-structured, one-to-one interviews among patients using AET from two hospitals and a local cancer organization. Interviews were conducted until theme saturation was achieved (N = 25). Interviews were de-identified, transcribed verbatim, and analysed using thematic analysis...
March 26, 2024: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://read.qxmd.com/read/38530432/chemotherapy-initiated-cysteine-rich-protein-61-decreases-acute-b-lymphoblastic-leukemia-chemosensitivity
#40
JOURNAL ARTICLE
Pengchong Shi, Zhen Lin, Yanfang Song, Zhaozhong Li, Menglu Zeng, Li Luo, Yingping Cao, Xianjin Zhu
PURPOSE: Chemoresistance is a major challenge for acute lymphoblastic leukemia (ALL) treatment. Cysteine-rich protein 61 (Cyr61) plays an important role in drug resistance modulation of tumor cells, and Cyr61 levels are increased in the bone marrow of patients with ALL and contribute to ALL cell survival. However, the effect of Cyr61 on B cell acute lymphoblastic leukemia (B-ALL) cell chemosensitivity and the regulatory mechanisms underlying Cyr61 production in bone marrow remain unknown...
March 26, 2024: Journal of Cancer Research and Clinical Oncology
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