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https://www.readbyqxmd.com/read/29908956/complement-activation-in-acute-myocardial-infarction-an-early-marker-of-inflammation-and-tissue-injury
#1
Lorena Bavia, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Miguel Ibraim Abboud Hanna Sobrinho, Renato Mitsunori Nisihara, Iara Jose de Messias-Reason
BACKGROUND: Acute myocardial infarction (AMI) is a potentially fatal condition, being a major cause of death worldwide. Ischemia suffered during AMI causes tissue damage, leading to an inflammatory process. Moreover, myocardial injury can generate damage-associated molecular patterns that activate pattern recognition molecules including some complement proteins. METHODS: Here we investigated products of complement activation, C3d and soluble C5b9 (sC5b9), as potential biomarkers for myocardial injury and inflammation, as well as serum cytokines (IL-6 and TNF-alpha), alpha-1-acid glycoprotein (AGP), and classical markers of myocardial necrosis (creatine kinase, creatine kinase-MB isoform, myoglobin and troponin-I) in a longitudinal study of patients with AMI (from admission, 6 h and 12 h post admission, and at discharge from hospital)...
June 14, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29907927/-1-h-mrs-spectroscopy-in-preclinical-autosomal-dominant-alzheimer-disease
#2
Elizabeth Joe, Luis D Medina, John M Ringman, Joseph O'Neill
1 H magnetic resonance spectroscopy (MRS) can reveal changes in brain biochemistry in vivo in humans and has been applied to late onset Alzheimer disease (AD). Carriers of mutations for autosomal dominant Alzheimer disease (ADAD) may show changes in levels of metabolites prior to the onset of clinical symptoms. Proton MR spectra were acquired at 1.5 T for 16 cognitively asymptomatic or mildly symptomatic mutation carriers (CDR < 1) and 11 non-carriers as part of a comprehensive cross-sectional study of preclinical ADAD...
June 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29906315/a-fixed-versus-weight-based-dosing-strategy-of-daptomycin-may-improve-safety-in-obese-adults
#3
Jill M Butterfield-Cowper, Thomas P Lodise, Manjunath P Pai
OBJECTIVES: To compare daptomycin exposures and predicted safety outcomes with a simulated weight-based and fixed dose in morbidly-obese and non-obese subjects METHODS: We performed a nonparametric population pharmacokinetic analysis of daptomycin concentration-time data from a prior obese and non-obese kidney function matched cohort of healthy adult volunteers. Monte Carlo simulations were performed to compare the maximum concentrations (Cmax ), minimum concentrations (Cmin ), and area under the curve (AUC) with the standard daptomycin 6-mg/kg/day dose or a 500-mg daily fixed dose in obese and non-obese subjects...
June 15, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29904441/ischemic-modified-albumin-predicts-critical-coronary-artery-disease-in-unstable-angina-pectoris-and-non-st-elevation-myocardial-infarction
#4
Abdullah Orhan Demirtas, Turgut Karabag, Derya Demirtas
Background: In this study, whether ischemia modified albumin (IMA) has a role in showing severity or criticality of coronary arteries in patients with unstable angina pectoris (USAP)/non-ST-elevation myocardial infarction (NSTEMI) was assessed. Methods: A total of 65 patients (40 male (M) and 25 female (F) patients; mean age 59.7 ± 12.1 years) with the initial diagnosis of USAP/NSTEMI were included in this study. The levels of IMA, troponin T, creatine kinase MB (CK-MB), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatinine, lipid panel, and whole blood count were measured from venous blood obtained from each patient within 3 h after the onset of symptoms...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904333/grape-seed-proanthocyanidin-extract-supplementation-affects-exhaustive-exercise-induced-fatigue-in-mice
#5
Liu Xianchu, Liu Ming, Liu Xiangbin, Zheng Lan
Background: Grape seed proanthocyanidin extract (GSPE) has been extensively reported to possess a wide range of beneficial properties in multiple tissue damage. Previous studies have shown that exhaustive exercise-induced fatigue associates with oxidative stress injury, inflammatory response, and mitochondrial dysfunction. Objective: The aim of this study is to investigate the anti-fatigue effects of GSPE in mice and explore its possible underlying mechanism. Design: The mouse model of exhaustive exercise-induced fatigue was established by using the forced swimming test, and GSPE was orally treated for successive 28 days at 0, 1, 50 and 100 mg/kg/day of body weight, designated the control, GSPE-L, GSPE-M and GSPE-H groups, respectively...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29903623/immune-checkpoint-mediated-myositis-and-myasthenia-gravis-a-case-report-and-review-of-evaluation-and-management
#6
Kylie H Kang, William Grubb, Komal Sawlani, Michael K Gibson, Christopher J Hoimes, Lisa R Rogers, Pierre Lavertu, Min Yao
BACKGROUND: We present a case of myositis and possible overlapping neuromuscular junction disorder following treatment with nivolumab for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). METHODS: We report a 75-year-old man with recurrent stage IVA, T1N2cM0 oral cavity HNSCC treated with weight-dosed nivolumab who presented three weeks later with severe fatigue, generalized weakness, and bilateral ptosis. Evaluation demonstrated elevated creatine kinase and myopathic motor units on electromyography, supporting a diagnosis of an underlying muscle disease...
June 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29902618/polycyclic-aromatic-hydrocarbon-exposure-impairs-pre-migratory-fuelling-in-captively-dosed-sanderling-calidris-alba
#7
Kristin Bianchini, Christy A Morrissey
Efficient fuelling is essential for migratory birds because fuel loads and fuelling rates affect individual fitness and survival during migration. Many migrant shorebirds are exposed to oil pollution and its toxic constituents, polycyclic aromatic hydrocarbons (PAHs), at migratory staging sites, which has the potential to interfere with avian refuelling physiology. In this study, we orally dosed shorebirds with environmentally-relevant PAH mixtures to simulate dietary exposure during staging. Forty-nine wild-caught Sanderling (Calidris alba) were exposed to 0 (control), 12...
June 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29902567/pre-and-post-surgery-mrsi-predictive-value-in-adult-oligodendroglioma-prognosis
#8
Caroline Bund, François Lefebvre, Roland Schott, Marie-Pierre Chenard, Benoît Lhermitte, Hélène Cebula, Stéphane Kremer, François Proust, Izzie-Jacques Namer
PURPOSE: The aim of this study was to study the relationship between MRSI, before and after surgery, and patient survival. The accuracy of pre-operative MRSI in differentiating low- from high-grade oligodendrogliomas (ODGs) was also studied. METHODS: Two hundred patients with ODG were retrospectively included in this study between 2000 and 2016. All patients underwent MRSI before any treatment or biopsy and/or after surgery for an intra-axial brain tumour. The R software was used for statistical data analysis...
June 11, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29902200/acrin-6684-multicenter-phase-ii-assessment-of-tumor-hypoxia-in-newly-diagnosed-glioblastoma-using-magnetic-resonance-spectroscopy
#9
Eva-Maria Ratai, Zheng Zhang, James Fink, Mark Muzi, Lucy Hanna, Erin Greco, Todd Richards, Daniel Kim, Ovidiu C Andronesi, Akiva Mintz, Lale Kostakoglu, Melissa Prah, Benjamin Ellingson, Kathleen Schmainda, Gregory Sorensen, Daniel Barboriak, David Mankoff, Elizabeth R Gerstner
A multi-center imaging trial by the American College of Radiology Imaging Network (ACRIN) "A Multicenter, phase II assessment of tumor hypoxia in glioblastoma using 18F Fluoromisonidazole (FMISO) with PET and MRI (ACRIN 6684)", was conducted to assess hypoxia in patients with glioblastoma (GBM). The aims of this study were to support the role of proton magnetic resonance spectroscopic imaging (1H MRSI) as a prognostic marker for brain tumor patients in multi-center clinical trials. Seventeen participants from four sites had analyzable 3D MRSI datasets acquired on Philips, GE or Siemens scanners at either 1...
2018: PloS One
https://www.readbyqxmd.com/read/29901562/massive-creatine-kinase-elevation-in-2-patients-during-short-term-and-low-dose-antipsychotic-monotherapy-with-quetiapine
#10
Patrick Bach, Anne Koopmann, Derik Hermann, Falk Kiefer, Jan Malte Bumb
No abstract text is available yet for this article.
June 12, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29901189/protective-effects-of-scoparone-against-ischemia%C3%A2-reperfusion%C3%A2-induced-myocardial-injury
#11
Chunfu Wan, Yueyue Wei, Jianguo Ma, Xiaoyong Geng
The present study aimed to investigate the protective effects and molecular mechanisms of scoparone on ischemia‑reperfusion (I/R) injury in primary cultured cardiac myocytes and rats. An in vivo rat model of I/R injury and an in vitro primary cultured cardiac myocyte model of oxygen‑glucose deprivation/reoxygenation were used to investigate the protective effects of scoparone. Cell viability, lactate dehydrogenase (LDH) release, superoxide dismutase (SOD), creatine kinase (CK) and malondialdehyde (MDA) levels, and reactive oxygen species (ROS) production were subsequently measured...
June 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900763/hematology-and-serum-biochemistry-values-of-the-red-panda-subspecies-ailurus-fulgens-styani
#12
Caitlin Burrell, Li Luo, Marieke Kester Jones, Andrea Lee, Elizabeth Freeman, Copper Aitken-Palmer
  Health evaluations were conducted on individuals ( n = 62, age < 1 to 11 yr) from a captive red panda ( Ailurus fulgens styani) population at the Chengdu Research Base for Giant Panda Breeding in Sichuan Province, People's Republic of China. Individuals were anesthetized using combinations of ketamine, dexmedetomidine, diazepam, isoflurane, and tiletamine/zolazepam. Whereas physical exams revealed no abnormalities for 40% of red pandas, 24% had dental abnormalities and 18% had orthopedic abnormalities...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29899766/actual-insights-into-treatable-inborn-errors-of-metabolism-causing-epilepsy
#13
REVIEW
Mario Mastrangelo
This review offers an update on a group of inborn errors of metabolism causing severe epilepsy with the onset in pediatric age (but also other neurological manifestations such as developmental delay or movement disorders) with available effective or potentially effective treatments. The main pathogenic and clinical features and general recommendations for the diagnostic and therapeutic workup of the following disorders are discussed: vitamin B6 -dependent epilepsies, cerebral folate deficiency, congenital disorders of serine metabolism, biotinidase deficiency, inborn errors of creatine metabolism, molybdenum cofactor deficiency, and glucose transporter 1 deficiency...
January 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29898675/in-hospital-major-arrhythmias-arrhythmic-death-and-resuscitation-after-successful-primary-percutaneous-intervention-for-acute-transmural-infarction-a-retrospective-single-centre-cohort-study
#14
Marco Albanese, Korhan Alpaslan, Taoufik Ouarrak, Peter Merguet, Steffen Schneider, Wolfgang Schöls
BACKGROUND: Transmural acute myocardial infarction (AMI) is associated with a high risk for ventricular arrhythmia before, during and after treatment. Consequently, it is recommended that patients diagnosed with transmural AMI be monitored in a cardiac care unit (CCU) so life-threatening arrhythmias can be treated promptly. We examined the incidence and timing of in-hospital malignant ventricular arrhythmias, sudden cardiac or arrhythmic death (SCD/AD) and resuscitation requirements in patients with transmural AMI recovering from percutaneous coronary intervention (PCI) undertaken within 12 h of symptom onset and without antecedent thrombolysis...
June 14, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29898248/serum-myoglobin-creatine-kinase-and-cell-free-dna-in-endurance-sled-dogs-and-sled-dogs-with-clinical-rhabdomyolysis
#15
Veronica C Devall, Robert Goggs, Christina Hansen, Christopher W Frye, Jo-Annie Letendre, Joseph J Wakshlag
OBJECTIVE: To evaluate whether cell-free DNA (cfDNA) concentrations are increased in dogs with exertional rhabdomyolysis and whether concentrations are correlated with serum myoglobin concentration and creatine kinase activity. DESIGN: Observational cohort study. SETTING: Yukon Quest 1,000-mile International Sled Dog Race 2015. ANIMALS: Twelve normal competitive sled dogs; 5 dogs with rhabdomyolysis. INTERVENTIONS: None...
June 13, 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29898093/x-linked-spinal-and-bulbar-muscular-atrophy-kennedy-s-disease-the-first-case-described-in-the-brazilian-amazon
#16
Camila Nascimento Alves, Tiago Kiyoshi Kitabayashi Braga, Danusa Neves Somensi, Bruno Sérgio Vilhena do Nascimento, José Antônio Santos de Lima, Satomi Fujihara
The X-linked spinal and bulbar muscular atrophy (Kennedy's disease) is a rare X-linked, recessive, lower motor neuron disease, characterized by weakness, atrophy, and fasciculations of the appendicular and bulbar muscle. The disease is caused by an expansion of the CAG repetition in the androgen receptor gene. Patients with Kennedy's disease have more than 39 CAG repetitions. We report a case of 57-year-old man, resident of Monte Dourado (PA, Brazil) who complained of brachiocrural paresis evolving for 3 years along with fasciculations and tremors of extremities...
June 7, 2018: Einstein
https://www.readbyqxmd.com/read/29898033/interleukin-6-contributes-to-myocardial-damage-in-pregnant-rats-with-reduced-uterine-perfusion-pressure
#17
Lan Ding, Chuanming Bai, Ying Liu
Preeclampsia is one of the most frequent and difficult illnesses in pregnancy, which jeopardizes both mother and fetus. There are several diagnostic criteria for preeclampsia. However, the preeclampsia-associated myocardial damage has not been described. In this study, we employed reduced uterine perfusion pressure (RUPP) to generate a rat model of preeclampsia for the evaluation of myocardial damage in late-gestation rats. The expressions of cardiac injury markers were analyzed by immunohistochemistry and ELISA...
June 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29897420/strong-relation-between-muscle-mass-determined-by-d3-creatine-dilution-physical-performance-and-incidence-of-falls-and-mobility-limitations-in-a-prospective-cohort-of-older-men
#18
Peggy M Cawthon, Eric S Orwoll, Katherine E Peters, Kristine E Ensrud, Jane A Cauley, Deborah M Kado, Marcia L Stefanick, James M Shikany, Elsa S Strotmeyer, Nancy W Glynn, Paolo Caserotti, Mahalakshmi Shankaran, Marc Hellerstein, Steven R Cummings, William J Evans
Background: Direct assessment of skeletal muscle mass in older adults is clinically challenging. Relationships between lean mass and late-life outcomes have been inconsistent. The D3-creatine dilution method provides a direct assessment of muscle mass. Methods: Muscle mass was assessed by D3-creatine (D3Cr) dilution in 1,382 men (mean age, 84.2 yrs). Participants completed the Short Physical Performance Battery (SPPB); usual walking speed (6 meters); and DXA lean mass...
June 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29896775/-1-h-nmr-based-water-soluble-lower-molecule-characterization-and-fatty-acid-composition-of-boiled-wuding-chicken-during-processing
#19
Zhichao Xiao, Yuting Luo, Guiying Wang, Changrong Ge, Guanghong Zhou, Wangang Zhang, Guozhou Liao
BACKGROUND: Boiled Wuding chicken was produced using whole chicken by washing, boiling 1 h with salt, deep frying and boiling 2 h. The effect of process on the WLOM (water-soluble lower molecule) profiles of products was characterized using proton nuclear magnetic resonance spectroscopy (1 H-NMR) and fatty acid composition of products was analyzed using gas chromatography-mass spectrometry (GC-MS). RESULTS: The metabonome was dominated by 49 WLOM and 22 fatty acid compounds were detected...
June 13, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29896235/curative-effect-of-posterior-lumbar-interbody-fusion-in-the-treatment-of-single-segment-lumbar-degenerative-disease-and-changes-in-adjacent-segment-quantitative-score
#20
Yan Zhuang, Feng Zhou, Yunqin Zhang, Zheng Jin
Curative effect of posterior lumbar interbody fusion (PLIF) in the treatment of single-segment lumbar degenerative disease and changes in adjacent segment quantitative score was investigated. A total of 86 patients with single-segment lumbar degenerative disease were randomly selected and divided into control group (n=43) and observation group (n=43). The control group was treated with posterolateral lumbar fusion, while the observation group was treated with PLIF. The observation group had a significantly longer operation time and shorter hospitalization time compared with the control group (P<0...
July 2018: Experimental and Therapeutic Medicine
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