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https://www.readbyqxmd.com/read/29787403/driving-comparisons-between-young-adults-with-autism-spectrum-disorder-and-typical-development
#1
Kristina E Patrick, Felicia Hurewitz, Mark D McCurdy, Frederic Taylor Agate, Brian P Daly, Reem A Tarazi, Douglas L Chute, Maria T Schultheis
OBJECTIVE: Many individuals with autism spectrum disorder (ASD) are reluctant to pursue driving because of concerns about their ability to drive safely. This study aimed to assess differences in simulated driving performance in young adults with ASD and typical development, examining relationships between driving performance and the level of experience (none, driver's permit, licensed) across increasingly difficult driving environments. METHOD: Participants included 50 English-speaking young adults (16-26 years old) with ASD matched for sex, age, and licensure with 50 typically-developing (TD) peers...
May 18, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29740451/therapeutic-administration-of-broadly-neutralizing-fi6-antibody-reveals-lack-of-interaction-between-human-igg1-and-pig-fc-receptors
#2
Sophie B Morgan, Barbara Holzer, Johanneke D Hemmink, Francisco J Salguero, John C Schwartz, Gloria Agatic, Elisabetta Cameroni, Barbara Guarino, Emily Porter, Pramila Rijal, Alain Townsend, Bryan Charleston, Davide Corti, Elma Tchilian
Influenza virus infection is a significant global health threat. Because of the lack of cross-protective universal vaccines, short time window during which antivirals are effective and drug resistance, new therapeutic anti-influenza strategies are required. Broadly, cross-protective antibodies that target conserved sites in the hemagglutinin (HA) stem region have been proposed as therapeutic agents. FI6 is the first proven such monoclonal antibody to bind to H1-H16 and is protective in mice and ferrets. Multiple studies have shown that Fc-dependent mechanisms are essential for FI6 in vivo efficacy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29721310/identification-of-microsatellite-loci-in-sea-anemones-aulactinia-stella-and-cribrinopsis-albopunctata-family-actiniidae
#3
Ekaterina S Bocharova, Alexey A Sergeev, Aleksandr A Volkov
From the DNA libraries enriched by the repeat motifs (AAAC) 6 , (AATC) 6 , (ACAG) 6 , (ACCT) 6 , (ACTC) 6 , ACTG) 6 , (AAAT) 8 , (AACT) 8 , (AAGT) 8 , (AGAT) 8 , for two viviparous sea anemones Aulactinia stella and Cribrinopsis albopunctata, 41 primer pairs were developed. These primer pairs resulted in the identification of 41 candidate microsatellite loci in either A. stella or C. albopunctata . Polymorphic loci were identified in both sea anemone species for 13 of the primer pairs and can be applicable for population genetics researches...
2018: F1000Research
https://www.readbyqxmd.com/read/29624809/characterization-of-demographics-and-ns5a-genetic-diversity-for-hcv-genotype-4-infected-patients-with-or-without-cirrhosis-treated-with-ombitasvir-paritaprevir-ritonavir
#4
Gretja Schnell, Rakesh Tripathi, Jill Beyer, Thomas Reisch, Preethi Krishnan, Tatyana Dekhtyar, Michelle Irvin, Coleen Hall, Yao Yu, Niloufar Mobashery, Rebecca Redman, Tami Pilot-Matias, Christine Collins
Hepatitis C virus (HCV) genotype 4 (GT4) is genetically diverse with 17 confirmed and 4 provisional subtypes. In this report, HCV GT4-infected patient samples from Phase 2/3 clinical studies were analyzed to characterize global demographics and genetic diversity of GT4 infection among patients treated with ombitasvir (OBV, NS5A inhibitor) plus paritaprevir/r (NS3/4A inhibitor co-dosed with ritonavir). Among 17 subtypes isolated from GT4-infected patients in the PEARL-I and AGATE-I studies, subtype prevalence by country of enrollment and country of origin suggested that subtypes 4a and 4d were likely circulating in Europe, while heterogeneous GT4 subtypes and a portion of GT4a detected in European and North American countries were likely due to immigration of HCV-infected patients from Africa...
April 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29619203/a-fluorenylidene-acridane-that-becomes-dark-in-color-upon-grinding-ground-state-mechanochromism-by-conformational-change
#5
Tsuyoshi Suzuki, Hiroshi Okada, Takafumi Nakagawa, Kazuki Komatsu, Chikako Fujimoto, Hiroyuki Kagi, Yutaka Matsuo
We report mechanochromic color change controlled by conformational change (between folded and twisted conformers) of fluorenylidene-acridanes (FAs). FAs with four N -alkyl groups (methyl, ethyl, n -butyl and n -octyl) were synthesized via the Barton-Kellogg reaction of diazofluorene and electrophilic N-tert -butoxy carbonyl thioacridone, deprotection of the tert -butoxy carbonyl group gives fluorenylacridine, and alkylation on the nitrogen atom is done using alkyl tosylate or triflate. FAs were characterized by NMR, UV-vis absorption and photoluminescence spectroscopy, theoretical calculation, cyclic voltammetry, and powder and single-crystal X-ray analyses...
January 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29301528/asymmetric-dimethylarginine-adma-symmetric-dimethylarginine-sdma-and-homoarginine-harg-the-adma-sdma-and-harg-paradoxes
#6
EDITORIAL
Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff, Arslan Arinc Kayacelebi
NG -Methylation of L-arginine (Arg) residues in certain proteins by protein arginine methyltransferases and subsequent proteolysis yields NG -monomethyl-L-arginine (MMA), NG ,NG -dimethyl-L-arginine (asymmetric dimethylarginine, ADMA) and NG ,N'G -dimethyl-L-arginine (symmetric dimethylarginine, SDMA). Biological MMA, ADMA and SDMA occur as free acids in the nM-range and as residues of proteins of largely unknown quantity. Arginine:glycine amidinotransferase (AGAT) catalyzes the synthesis of L-homoarginine (hArg) from free Arg and L-lysine...
January 4, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29236952/impaired-cardiac-contractile-function-in-agat-knockout-mice-devoid-of-creatine-is-rescued-by-homoarginine-but-not-creatine
#7
Kiterie M E Faller, Dorothee Atzler, Debra J McAndrew, Sevasti Zervou, Hannah J Whittington, Jillian N Simon, Dunja Aksentijevic, Michiel Ten Hove, Chi-Un Choe, Dirk Isbrandt, Barbara Casadei, Jurgen E Schneider, Stefan Neubauer, Craig A Lygate
Aims: Creatine buffers cellular ATP via the creatine kinase reaction. Creatine levels are reduced in heart failure, but their contribution to pathophysiology is unclear. Arginine:glycine amidinotransferase (AGAT) in the kidney catalyses both the first step in creatine biosynthesis as well as homoarginine synthesis. AGAT-/- mice fed a creatine-free diet have a whole body creatine-deficiency. We hypothesised that AGAT-/- mice would develop cardiac dysfunction and rescue by dietary creatine would imply causality...
December 11, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29229397/di-acetyl-creatine-ethyl-ester-a-new-creatine-derivative-for-the-possible-treatment-of-creatine-transporter-deficiency
#8
Enrico Adriano, Maurizio Gulino, Maria Arkel, Annalisa Salis, Gianluca Damonte, Nara Liessi, Enrico Millo, Patrizia Garbati, Maurizio Balestrino
Creatine is pivotal in energy metabolism of the brain. In primary creatine deficiency syndromes, creatine is missing from the brain. Two of them (AGAT and GAMT deficiency) are due to impaired creatine synthesis, and can be treated by creatine supplementation. By contrast, creatine transporter deficiency cannot be treated by such supplementation, since creatine crossing of biological membranes (plasma membrane and blood-brain barrier) is dependent on its transporter. This problem might be overcome by modifying the creatine molecule to allow it to cross biological membranes independently of its transporter...
February 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29226642/homoarginine-associates-with-zonulin-and-tryptophan-findings-in-a-high-risk-cohort-of-patients-carrying-an-aicd
#9
Elli Mann, Robert Kluesener, Felix Boschann, Jana Ruppert, Franz P Armbruster, Andreas Meinitzer, Christoph Melzer, Thomas B Dschietzig
BACKGROUND: Homoarginine (hArg) is known to have an impact on nitric oxide (NO) metabolism. It seems to increase NO generation and/or availability, thereby enhancing endothelial function. In addition, hArg is connected to energy metabolism since the key enzyme, L-arginine-glycine amidinotransferase (AGAT) for hArg synthesis in the kidneys, is also involved in the synthesis of energy metabolites like guanidinoacetate. Former studies indicate that low levels of hArg are linked to cardiovascular disease and increased all-cause mortality...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29209753/-neuroleptic-malignant-syndrome
#10
REVIEW
R Knorr, J Schöllkopf, E Haen
BACKGROUND: Neuroleptic malignant syndrome (NMS) is a rare but severe undesired complication of psychopharmacological treatment. The mortality has shown a significant decrease since its first description. Knowledge of NMS is important for every clinician because of the need for rapid diagnosis and treatment. OBJECTIVE: This article presents a review and critical appraisal of the current study situation for NMS. Recommendations for diagnostics, differential diagnostics and treatment are presented particularly from a clinical perspective...
March 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29161152/proliferative-cells-isolated-from-the-adult-human-peripheral-retina-only-transiently-upregulate-key-retinal-markers-upon-induced-differentiation
#11
Erik O Johnsen, Rebecca C Frøen, Ole Kristoffer Olstad, Bjørn Nicolaissen, Goran Petrovski, Morten C Moe, Agate Noer
Purpose/Aim: The adult human retina has limited regenerative potential, and severe injury will result in permanent damage. Lower vertebrates handle retinal injury by activating neural stem cells (NSCs) in the ciliary marginal zone (CMZ). Müller glia-like cells expressing markers of NSCs are also present in the peripheral retina (PR) of the adult human eye, leading to the hypothesis that a CMZ-like zone might exists also in humans. In order to shed further light on this hypothesis we investigated the in vitro differentiation potential of proliferative cells isolated from the adult human PR towards a retinal phenotype...
March 2018: Current Eye Research
https://www.readbyqxmd.com/read/29126009/characteristics-and-origin-of-agates-from-p%C3%A5-%C3%A3-czki-g%C3%A3-rne-lower-silesia-poland-a-combined-microscopic-micro-raman-and-cathodoluminescence-study
#12
Magdalena Dumańska-Słowik, Tomasz Powolny, Magdalena Sikorska-Jaworowska, Adam Gaweł, Lucyna Kogut, Krzysztof Poloński
Agates from Płóczki Górne hosted by Permian basaltic rocks are predominantly made of length-fast chalcedony, and subordinately megaquartz and quartzine. Moganite occurs in traces mainly in transparent, outer, darker regions of white-grey coloured agates. Silica matrix of agates comprises a wide variety of solid inclusions represented by celadonite, plagioclases, hematite, goethite, barite, calcite, heulandite-clinoptyloite, nontronite-saponite, and Mn-dioxides (ramsdellite). Mineral phases are locally accompanied by black aggregations of carbonaceous matter, which gives a Raman signature of disordered carbon...
March 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29110129/real-life-management-and-outcome-of-thyroid-carcinoma-related-bone-metastases-results-from-a-nationwide-multicenter-experience
#13
G Mazziotti, A M Formenti, M B Panarotto, E Arvat, A Chiti, A Cuocolo, M E Dottorini, C Durante, L Agate, S Filetti, F Felicetti, A Filice, L Pace, T Pellegrino, M Rodari, M Salvatori, C Tranfaglia, A Versari, D Viola, S Frara, A Berruti, A Giustina, R Giubbini
PURPOSE AND PATIENTS: The M.O.S.CA.TI. (Metastases of the Skeleton from CArcinoma of the ThyroId) is a multicenter, retrospective study investigating the real-life outcome and management of bone metastases (BM) in 143 patients (63 M, 80 F; median age 64 years, range 11-87) with differentiated thyroid carcinoma (DTC). RESULTS: Radio-active iodine (RAI) treatment was performed in 131 patients (91.6%), surgical approach and/or external radiotherapy in 68 patients (47...
January 2018: Endocrine
https://www.readbyqxmd.com/read/29033534/multicellular-tumor-spheroids-of-human-uveal-melanoma-induce-genes-associated-with-anoikis-resistance-lipogenesis-and-ssxs
#14
Charlotte Ness, Øystein Garred, Nils A Eide, Theresa Kumar, Ole K Olstad, Thomas P Bærland, Goran Petrovski, Morten C Moe, Agate Noer
PURPOSE: Uveal melanoma (UM) has a high propensity for metastatic spread, and approximately 40-50% of patients die of metastatic disease. Metastases can be found at the time of diagnosis but also several years after the tumor has been removed. The survival of disseminated cancer cells is known to be linked to anchorage independence, anoikis resistance, and an adaptive cellular metabolism. The cultivation of cancer cells as multicellular tumor spheroids (MCTS) by anchorage-independent growth enriches for a more aggressive phenotype...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28971744/benefits-and-drawbacks-of-guanidinoacetic-acid-as-a-possible-treatment-to-replenish-cerebral-creatine-in-agat-deficiency
#15
Sergej M Ostojic
Arginine-glycine amidinotransferase (AGAT) deficiency is a rare inherited metabolic disorder that severely affects brain bioenergetics. Characterized by mental retardation, language impairment, and behavioral disorders, AGAT deficiency is a treatable condition, where long-term creatine supplementation usually restores brain creatine levels and improves its clinical features. In some cases of AGAT deficiency, creatine treatment might be somewhat limited due to possible shortcomings in performance and transport of creatine to the brain...
October 3, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28911728/protein-kinase-inhibitors-for-the-treatment-of-advanced-and-progressive-radiorefractory-thyroid-tumors-from-the-clinical-trials-to-the-real-life
#16
REVIEW
Antonio Matrone, Laura Valerio, Letizia Pieruzzi, Carlotta Giani, Virginia Cappagli, Loredana Lorusso, Laura Agate, Luciana Puleo, David Viola, Valeria Bottici, Marzia Del Re, Eleonora Molinaro, Romano Danesi, Rossella Elisei
The last ten years have been characterized by the introduction in the clinical practice of new drugs named tyrosine kinase inhibitors for the treatment of several human tumors. After the positive conclusion of two international multicentric, randomized phase III clinical trials, two of these drugs, sorafenib and lenvatinib, have been recently approved and they are now available for the treatment of advanced and progressive radioiodine refractory thyroid tumors. We have been involved in most clinical trials performed with different tyrosine kinase inhibitors in different histotypes of thyroid cancer thus acquiring a lot of experience in the management of both drugs and their adverse events...
June 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28911147/kif5b-ret-rearrangement-in-a-carcinoma-of-the-thyroid-gland-a-case-report-of-a-fatal-disease
#17
David Viola, Carlotta Giani, Salvatore Mazzeo, Clara Ugolini, Raffaele Ciampi, Eleonora Molinaro, Laura Agate, Nicla Borrelli, Antonio Chella, Gabriella Fontanini, Fulvio Basolo, Rossella Elisei
Background: The diffuse sclerosing variant of papillary thyroid cancer (DSV-PTC) is a rare variant of papillary thyroid cancer (PTC) with different clinicopathological features compared with conventional PTC. Case: An advanced DSV-PTC was diagnosed in a 39-year-old man. The radioiodine posttherapeutic whole-body-scan showed only an uptake in the central neck, whereas the computerized tomography showed multiple latero-cervical and mediastinum lymph node metastases, a single and spiculated lung lesion and multiple bilateral cerebellum metastases...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28894572/comparison-between-digital-and-optical-microscopy-analysis-in-a-mouse-gut-inflammation-model
#18
Airton Pereira E Silva, Sylvia Maria Nicolau Campos, Isabelle Mazza Guimarães, Gerlinde Agate Platais Brasil Teixeira
Virtual microscopy is currently widely used for various purposes, such as teaching, archiving, collaborations and research. Although the cost of this technique has reduced, it continues to be expensive for the majority of laboratories in developing countries. The Graduate Program in Pathology at the Federal Fluminense University (Niterói, Brazil) has acquired equipment for virtual microscopy. However, this novel method faced prejudice, as students and technicians were skeptical about its reliability. Thus, the aim of the current study was to evaluate whether virtual microscopy is a reliable method of analysis for our research...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28872183/ex-vivo-3d-human-corneal-stroma-model-for-schnyder-corneal-dystrophy-role-of-autophagy-in-its-pathogenesis-and-resolution
#19
Dóra Júlia Szabó, Richárd Nagymihály, Zoltán Veréb, Natasha Josifovska, Agate Noer, Petra Liskova, Andrea Facskó, Morten C Moe, Goran Petrovski
INTRODUCTION: Multilamellar bodies (MLBs) are concentric cytoplasmic membranes which form through an autophagy-dependent mechanism. In the cornea, the presence of MLBs is associated with Schnyder corneal dystrophy (SCD). Ex vivo 3D modelling of the corneal stroma and SCD can help study pathogenesis and resolution of the disorder. METHODS: Corneal stroma explants were isolated from cadavers and cultivated long-term for more than 3 months to achieve spontaneous 3D outgrowth of corneal stroma-derived mesenchymal stem-like cells (CSMSCs)...
September 5, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28846669/creatine-supplementation-to-total-parenteral-nutrition-improves-creatine-status-and-supports-greater-liver-and-kidney-protein-synthesis-in-neonatal-piglets
#20
O Chandani Dinesh, Robert F Bertolo, Janet A Brunton
BackgroundCreatine is not included in commercial pediatric parenteral products; the entire creatine requirement must be met by de novo synthesis from arginine during parenteral nutrition (PN). Poor arginine status is common during PN in neonates, which may compromise creatine accretion. We hypothesized that creatine supplementation will improve creatine status and spare arginine in PN-fed piglets.MethodsPiglets (3-5-day (d) old) were provided PN with or without creatine for 14 d. Tissue concentrations of creatine metabolites and activities of creatine-synthesizing enzymes, as well as tissue protein synthesis rates and liver lipid parameters, were measured...
January 2018: Pediatric Research
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