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https://www.readbyqxmd.com/read/29166723/-association-between-serum-n%C3%AE%C2%B5-carboxymethyl-lysine-level-and-anterior-tibial-arterial-plaque-calcification-in-patients-with-diabetic-foot-post-foot-amputation
#1
L H Li, F Ye, X L Fu, S N Xu, Z Y Bao, Z Sun, J C Yan, J N Wu, Z Q Wang
Objective: To observe the correlation between Nε-carboxymethyl-Lysine (CML), the main component of advanced glycation end products and the calcification of the anterior tibial artery plaque in patients with diabetic foot post foot amputation. Methods: Sixty patients hospitalized for foot amputation operation due to diabetic foot from June 2012 to June 2016 in the Department of Orthopedics, Affiliated Hospital of Jiangsu University were prospectively recruited.The patients were categorized into mild stenosis (0<stenosis<50%, n=20), moderate stenosis (50%≤stenosis<70%, n=20) and severe stenosis (70%≤stenosis≤100%, n=20) based on the color Doppler ultrasound assessed severity of anterior tibial artery stenosis...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166720/-long-term-safety-and-efficacy-of-a-novel-abluminal-groove-filled-biodegradable-polymer-sirolimus-eluting-stent-for-the-treatment-of-coronary-de-novo-lesions
#2
C J Li, B Xu, C D Guan, R L Gao
Objective: To compare the long term safety and efficacy of the novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent(Firehawk stent) and permanent polymer coating everolimus eluting stent(Xience V stent) for the treatment of coronary de novo lesions. Methods: This prospective, multi-center, non-inferiority, randomized control trial(TARGETⅠ trial) was performed between August 2010 and April 2011, a total of 460 patients with primary, de novo, single vessel and single coronary lesion from 16 medical centers were enrolled...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166699/comparison-of-clinical-outcomes-of-coronary-artery-stent-implantation-in-patients-with-end-stage-chronic-kidney-disease-including-hemodialysis-for-three-everolimus-eluting-ees-stent-designs-bioresorbable-polymer-ees-platinum-chromium-ees-and-cobalt-chrome-ees
#3
Takao Sato, Katsuharu Hatada, Syohei Kishi, Koichi Fuse, Satoshi Fujita, Yoshio Ikeda, Minoru Takahashi, Taku Matsubara, Masaaki Okabe, Yoshifusa Aizawa
BACKGROUNDS: New-generation bioresorbable polymer-everolimus eluting stents (BP-EES) are available. This study aimed to compare the clinical outcomes for BP-EES compared to more established stent designs, namely the platinum chromium-EES (PtCr-EES) and cobalt chrome-EES(CoCr-EES) in patients with the end-stage chronic kidney disease (CKD) including hemodialysis (HD). METHODS: One-hundred-forty-one consecutive stents (BP-EES [n = 44], PtCr-EES [n = 45], and CoCr-EES [n = 52]) were implanted in 104 patients with CKD...
November 22, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29166543/transcatheter-or-surgical-aortic-valve-replacement-in-patients-with-advanced-kidney-disease-a-propensity-score-matched-analysis
#4
Rajkumar Doshi, Jay Shah, Vaibhav Patel, Varun Jauhar, Perwaiz Meraj
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is an alternative for surgically inoperable patients with severe aortic stenosis. Advanced kidney disease may significantly affect outcomes in patients treated with TAVR and surgical aortic valve replacement (SAVR). HYPOTHESIS: TAVR is associated with better in-hospital outcomes compared with SAVR in patients with advanced kidney disease. METHODS: We identified our sample from the National Inpatient Sample between 2012 and 2014, using International Classification of Diseases, Ninth Revision, Clinical Modification codes...
November 22, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29165757/clinical-effects-of-ascending-colon-patching-ileorectal-heart-shaped-anastomosis-on-total-colonic-aganglionosis
#5
S-X Li, H-W Zhang, H Cao, H-X Zou, Y-Y Yin, F Sui, X Zhang
OBJECTIVE: We studied the clinical effects of ascending colon patching ileorectal heart-shaped anastomosis in treating total colonic aganglionosis. PATIENTS AND METHODS: From June 2006 to June 2013, 15 children with severe abdominal distension, low small intestine obstruction and intestinal perforation in the neonatal period, were enrolled in this study. In phase I, patients received emergency terminal ileum stoma plus multi-site colonic biopsy and 6 to 12 months later, ascending colon patching ileorectal heart-shaped anastomosis was conducted in phase II...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29165642/the-corticospinal-reserve-capacity-reorganization-of-motor-area-and-excitability-as-a-novel-pathophysiological-concept-in-cervical-myelopathy
#6
Anna Zdunczyk, Vera Schwarzer, Michael Mikhailov, Brendon Bagley, Tizian Rosenstock, Thomas Picht, Peter Vajkoczy
BACKGROUND: In degenerative cervical myelopathy (DCM), the dynamics of disease progression and the outcome after surgical decompression vary interindividually and do not necessarily correlate with radiological findings. OBJECTIVE: To improve diagnostic power in DCM by better characterization of the underlying pathophysiology using navigated transcranial magnetic stimulation (nTMS). METHODS: Eighteen patients with DCM due to cervical spinal canal stenosis were examined preoperatively with nTMS...
November 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29165416/-a-case-of-progressive-glaucoma-against-the-background-of-chronic-constipation
#7
A E Vasil'eva, N V Makashova, I A Ronzina, O Yu Kolosova, K V Goncharenko
The authors describe a case of severe glaucoma in the only seeing eye of a patient with venous circulation disturbance resulting from a chronic anal fissure complicated with progressive anal stenosis, severe sphincter spasm, and pain syndrome. The article presents the results of multiple clinical ophthalmological tests and instrumental examinations performed before and after surgical intervention that evidence the importance of venous circulation disturbances for glaucoma development.
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165239/does-smoking-affect-the-outcomes-of-lumbar-decompression-surgery
#8
Radha Mehta, Himanshu Sharma
INTRODUCTION: Lumbar decompressions and micro-discectomies are commonly performed non-complex spinal surgeries that do not involve the insertion of metalwork into the spine and are done for symptomatic disc prolapse and lumbar spinal stenosis, whereas complex-spinal surgery does require metalwork [1]. Studies of complex-spinal surgeries show that smoking has a significant negative impact on the outcome of the surgery [2] therefore, the cessation of smoking is advised prior to surgery [3]...
2017: SICOT-J
https://www.readbyqxmd.com/read/29165161/rare-variants-of-rnf213-and-moyamoya-non-moyamoya-intracranial-artery-stenosis-occlusion-disease-risk-a-meta-analysis-and-systematic-review
#9
Xin Liao, Jing Deng, Wenjie Dai, Tong Zhang, Junxia Yan
BACKGROUND: The p.R4810K and other rare variants of ring finger protein 213 gene (RNF213) were illustrated as susceptibility variants for moyamoya (MMD) and non-moyamoya intracranial artery stenosis/occlusion disease (ICASO) recently. However, the effect sizes of p.R4810K were in great discrepancy even in studies of the same ethnic population and firm conclusions of other rare variants have been elusive given the small sample sizes and lack of replication. Thus, we performed this study to quantitatively evaluate whether or to what extent the rare variants of RNF213 contribute to MMD and ICASO in different populations...
November 2, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165136/genetic-analysis-of-rnf213-p-r4810k-variant-in-non-moyamoya-intracranial-artery-stenosis-occlusion-disease-in-a-chinese-population
#10
Tong Zhang, Congrong Guo, Xin Liao, Jian Xia, XiaoXiao Wang, Jing Deng, Junxia Yan
OBJECTIVES: RNF213 p.R4810K was identified as a susceptibility variant for moyamoya disease in Asia and non-moyamoya intracranial artery stenosis/occlusion disease in Japan and Korea recently. The occurrence of this variant was evaluated in patients with non-moyamoya intracranial artery stenosis/occlusion disease in China. METHODS: Two study populations were used in this study. One was recruited from the Second Hospital of Hebei Medical University from April 2015 to May 2016...
April 24, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29164621/determining-candidate-single-nucleotide-polymorphisms-in-acquired-laryngotracheal-stenosis
#11
Mursalin M Anis, Natalia Krynetskaia, Zhigen Zhao, Evgeny Krynetskiy, Ahmed M S Soliman
OBJECTIVES/HYPOTHESIS: Despite wide adoption of strategies to prevent injury from prolonged intubation and tracheotomy, acquired laryngotracheal stenosis (ALTS) has not disappeared. ALTS' persistence may be due to patient factors that confer unique susceptibility for some. We sought to identify genetic markers in genes associated with wound healing that could be associated with ALTS. STUDY DESIGN: Case-control study. METHODS: One hundred thirty-eight patients were recruited, 53 patients with ALTS and 85 control patients who underwent intubation or tracheotomy without evidence of ALTS...
November 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29164555/an-insight-into-the-role-of-cyclooxygenase-and-lipooxygenase-pathway-in-renal-ischemia
#12
M Kinra, J Mudgal, D Arora, M Nampoothiri
OBJECTIVE: Renal ischemia (RI) is a clinical condition that occurs due to marked decrease in renal blood flow. The pathophysiology of RI is interlinked with atherosclerotic renal artery stenosis, infarction, organ transplantation and sepsis. The mechanism of RI injury depends on various factors such as inflammatory response, oxidative stress and apoptosis. In this review, we evaluate the role of cyclooxygenase and lipoxygenase in modulating the process of ischemic renal injury. MATERIALS AND METHODS: This is a literature review of articles published on PubMed and Web of Science in English...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164403/a-novel-photodynamic-therapy-based-drug-delivery-system-layered-on-a-stent-for-treating-cholangiocarcinoma
#13
Po-Chin Liang, Kai-Wen Huang, Chien-Chih Tung, Ming-Chu Chang, Fuh-Yu Chang, Jau-Min Wong, Yu-Ting Chang
This study aimed to investigate the drug delivery efficacy and bio-effectiveness of a novel photodynamic therapy (PDT)-matrix drug delivery system for cholangiocarcinoma (CCA). Metallic stents were coated with polyurethane (PU) as the first layer. A 2-hydroxyethyl methacrylate (2-HEMA)/ethylene glycol dimethacrylate (EGDMA)/benzoyl peroxide (BPO) layer and a poly(ethylene-co-vinyl acetate) (PEVA)/poly(n-butyl methacrylate) (PBMA)/polyvinylpyrrolidone K30 (K30) layer containing various concentrations of Photofrin were then incorporated onto the stent as the second and third layers...
November 22, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/29163969/ercp-in-infants-children-and-adolescents-is-feasible-and-safe-results-from-a-tertiary-care-center
#14
Jasmin Felux, Ekkehard Sturm, Andreas Busch, Emanuel Zerabruck, Florian Graepler, Dietmar Stüker, Andreas Manger, Hans-Joachim Kirschner, Gunnar Blumenstock, Nisar P Malek, Martin Goetz
Background: Indications for endoscopic retrograde cholangiopancreatography (ERCP) in children differ from adults. Paucity of data and concerns about potential lower effectiveness and more side effects limit its use even in high volume centers. We retrospectively analyzed indications, success rates, limitations, and side effects of ERCPs in children <18 years. Methods: From January 2012 to March 2015, 54 ERCPs were performed in 31 children (median age 11 (0-17) years; median weight 22 (3...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29163956/eversion-endarterectomy-under-full-prasugrel-treatment
#15
Thomas Kotsis, Panagitsa Christoforou, Nikolaos Asaloumidis, Erifyli Argyra
The third-generation thienopyridine prasugrel has much stronger antiplatelet effect compared to other current antiplatelet inhibitors and exhibits practically zero resistance in healthy people. Prasugrel is used as a pre- and post-treatment in percutaneous coronary or neurovascular interventions with parallel aspirin regime. However, as there is a higher reported bleeding with intraluminal interventions and meticulous technique is recommended, there is nearly non-existent international experience of open surgery under full prasugrel treatment...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29163747/endovascular-stenting-of-tandem-carotid-artery-origin-and-bifurcation-stenotic-lesions-using-flow-reversal
#16
Andrew A Fanous, Parham Yashar, Ashish Sonig, Amanda Zakeri, Kenneth V Snyder, Elad I Levy, Jason M Davies, Adnan H Siddiqui
Background: The treatment of tandem lesions involving severe stenosis of the internal carotid artery with concomitant stenosis of the ipsilateral common carotid artery (CCA) origin represents an ongoing challenge. Current options for the treatment of tandem carotid artery origin and bifurcation stenotic lesions include open surgical endarterectomy, endovascular stenting, balloon angioplasty, and hybrid procedures combining both modalities. However, these options are either associated with high peri-operative risks or not always anatomically feasible...
October 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29163214/predictive-value-of-dynamic-cerebral-autoregulation-assessment-in-surgical-management-of-patients-with-high-grade-carotid-artery-stenosis
#17
Vladimir B Semenyutin, Gregory A Asaturyan, Anna A Nikiforova, Vugar A Aliev, Grigory K Panuntsev, Vadim B Iblyaminov, Alexander V Savello, Andreas Patzak
Dynamic cerebral autoregulation (DCA) capacity along with the degree of internal carotid artery (ICA) stenosis and characteristics of the plaque can also play an important role in selection of appropriate treatment strategy. This study aims to classify the patients with severe ICA stenosis according to preoperative state of DCA and to assess its dynamics after surgery. Thirty-five patients with severe ICA stenosis having different clinical type of disease underwent reconstructive surgery. DCA was assessed with transfer function analysis (TFA) by calculating phase shift (PS) between Mayer waves of blood flow velocity (BFV) and blood pressure (BP) before and after operation...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162782/recurrent-early-coronary-stent-thrombosis-under-chronic-disseminated-intravascular-coagulation
#18
Yusuke Oba, Satoshi Hoshide, Tadayuki Mitama, Hajime Shinohara, Takahiro Komori, Tomoyuki Kabutoya, Yasushi Imai, Nobuhiko Ogata, Kazuomi Kario
A 62-year-old Japanese man presented with chest pain indicating that acute myocardial infarction had occurred. Eleven years earlier, he underwent a splenectomy due to idiopathic portal hypertension. Coronary angiography revealed diffuse stenosis, with calcification in the left anterior descending coronary artery (LAD). We performed a primary percutaneous coronary intervention (PCI). We deployed two drug-eluting stents with sufficient minimal cross-sectional stent area by intravascular ultrasound and thrombolysis in myocardial infarction (TIMI) 3 flow...
November 22, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29162610/angiography-versus-hemodynamics-to-predict-the-natural-history-of-coronary-stenoses-a-fame-2-substudy
#19
Giovanni Ciccarelli, Emanuele Barbato, Gabor G Toth, Brigitta Gahl, Panagiotis Xaplanteris, Stephane Fournier, Anastasios Milkas, Jozef Bartunek, Marc Vanderheyden, Nico Pijls, Pim Tonino, William F Fearon, Peter Jüni, Bernard De Bruyne
Background -Among patients with documented stable coronary artery disease (CAD) and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and of fractional flow reserve (FFR) in predicting natural history. Methods -The present analysis included the 607 patients from the Fractional flow reserve versus angiography in multivessel evaluation 2 (FAME 2) trial in whom no revascularization was performed. FFR varied from 0.20 to 1.00 (average 0.74 ± 0...
November 21, 2017: Circulation
https://www.readbyqxmd.com/read/29162138/predictability-of-the-effects-of-facet-joint-infiltration-in-the-degenerate-lumbar-spine-when-assessing-mri-scans
#20
Ulf Krister Hofmann, Ramona Luise Keller, Christian Walter, Falk Mittag
BACKGROUND: Imaging results are frequently considered as hallmarks of disease by spine surgeons to plan their future treatment strategy. Numerous classification systems have been proposed to quantify or grade lumbar magnetic resonance imaging (MRI) scans and thus objectify imaging findings. The clinical impact of the measured parameters remains, however, unclear. To evaluate the pathological significance of imaging findings in patients with multisegmental degenerative findings, clinicians can perform image-guided local infiltrations to target defined areas such as the facet joints...
November 21, 2017: Journal of Orthopaedic Surgery and Research
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