keyword
https://read.qxmd.com/read/38533280/evaluation-of-effect-of-montelukast-in-the-model-of-streptozotocin-induced-diabetic-nephropathy-in-rats
#21
JOURNAL ARTICLE
Dhananjay Kokate, Padmaja Marathe
BACKGROUND: Diabetic nephropathy is a progressive condition and a leading cause of end-stage renal disease. Oxidative stress and inflammation play an important role in its pathogenesis. In pre-clinical studies, Montelukast had shown renoprotective and anti-oxidant properties, hence the study was planned to evaluate the effect of Montelukast in a Streptozotocin (STZ) induced model of diabetic nephropathy. METHODS: 40 Wistar rats of either sex were randomly divided into four groups viz ...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532241/gene-expression-analysis-in-t2dm-and-its-associated-microvascular-diabetic-complications-focus-on-risk-factor-and-raas-pathway
#22
JOURNAL ARTICLE
Laxmipriya Jena, Prabhsimran Kaur, Tashvinder Singh, Kangan Sharma, Sushil Kotru, Anjana Munshi
Prolonged hyperglycemic conditions in type 2 diabetes mellitus (T2DM) cause pathological and functional damage to many organs and tissues, including the kidneys, retina, skin, and neuronal tissues, resulting in the development of microvascular diabetic complications. The altered renin angiotensin aldosterone system (RAAS) pathway has been reported to play an important role in the development of insulin resistance in T2DM and associated complications. The current study was carried out to evaluate the association of risk factors and altered expression of RAAS genes in T2DM patients without complications and T2DM patients with complications (retinopathy, nephropathy, and neuropathy)...
March 27, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38529001/exacerbation-of-diabetic-retinopathy-following-hypoxia-inducible-factor-prolyl-hydroxylase-inhibitor-administration-a-case-report
#23
Nobuaki Ariyoshi, Fumiaki Higashijima, Makiko Wakuta, Tadahiko Ogata, Manami Ohta, Kazuhiro Kimura
INTRODUCTION: Hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors, used in the treatment of renal anemia, hold the potential to increase the production of vascular endothelial growth factors. Therefore, HIF-PH inhibitors may exacerbate retinal hemorrhage in diseases such as diabetic retinopathy. Here, we present a case involving the administration of an HIF-PH inhibitor, resulting in the exacerbation of retinal hemorrhage in a patient with diabetic retinopathy. CASE PRESENTATION: A 32-year-old man with diabetes mellitus and renal anemia caused by diabetic nephropathy was referred to our department for ophthalmic examination, revealing diabetic retinopathy with scattered retinal hemorrhages, exudates, and diabetic maculopathy in both eyes...
2024: Case Reports in Ophthalmology
https://read.qxmd.com/read/38527400/the-redox-sensitive-gsk3%C3%AE-is-a-key-regulator-of-glomerular-podocyte-injury-in-type-2-diabetic-kidney-disease
#24
JOURNAL ARTICLE
Mengxuan Chen, Yudong Fang, Yan Ge, Shuhao Qiu, Lance Dworkin, Rujun Gong
Emerging evidence suggests that GSK3β, a redox-sensitive transducer downstream of insulin signaling, acts as a convergent point for myriad pathways implicated in kidney injury, repair, and regeneration. However, its role in diabetic kidney disease remains controversial. In cultured glomerular podocytes, exposure to a milieu of type 2 diabetes elicited prominent signs of podocyte injury and degeneration, marked by loss of homeostatic marker proteins like synaptopodin, actin cytoskeleton disruption, oxidative stress, apoptosis, and stress-induced premature senescence, as shown by increased staining for senescence-associated β-galactosidase activity, amplified formation of γH2AX foci, and elevated expression of mediators of senescence signaling, like p21 and p16INK4A ...
March 16, 2024: Redox Biology
https://read.qxmd.com/read/38525833/-chicoric-acid-advanced-paqr3-ubiquitination-to-ameliorate-ferroptosis-in-diabetes-nephropathy-through-the-relieving-of-the-interaction-between-paqr3-and-p110%C3%AE-pathway
#25
JOURNAL ARTICLE
Weiwei Zhang, Yong Liu, Jiajun Zhou, Teng Qiu, Haitang Xie, Zhichen Pu
PURPOSE: This study aimed to examine the impact of CA on DN and elucidate its underlying molecular mechanisms of inflammation. METHODS: We fed C57BL/6 mice injected with streptozotocin to induce diabetes. In addition, we stimulated NRK-52E cells with 20 mmol/L d-glucose to mimic the diabetic condition. RESULTS: Our findings demonstrated that CA effectively reduced blood glucose levels, and improved DN in mice models. Additionally, CA reduced kidney injury and inflammation in both mice models and in vitro models...
December 31, 2024: Clinical and Experimental Hypertension: CHE
https://read.qxmd.com/read/38525377/sglt2-inhibitors-beyond-glycemic-control
#26
JOURNAL ARTICLE
Irtiza Hasan, Tasnuva Rashid, Vishal Jaikaransingh, Charles Heilig, Emaad M Abdel-Rahman, Alaa S Awad
Multiple randomized controlled trials have extensively examined the therapeutic effectiveness of sodium-glucose cotransporter 2 (SGLT2) inhibitors, ushering in a transformative approach to treating individuals with type 2 diabetes mellitus (DM). Notably, emerging reports have drawn attention to the potential positive impacts of SGLT2 inhibitors in nondiabetic patients. In an effort to delve into this phenomenon, a comprehensive systematic literature review spanning PubMed (NLM), Medline (Ovid), and Cochrane Library, covering publications from 2000 to 2024 was undertaken...
March 2024: Journal of Clinical & Translational Endocrinology
https://read.qxmd.com/read/38524936/biomarkers-and-signaling-pathways-of-diabetic-nephropathy-and-peripheral-neuropathy-possible-therapeutic-intervention-of-rutin-and-quercetin
#27
REVIEW
Tamsheel Fatima Roohi, Seema Mehdi, Sadaf Aarfi, K L Krishna, Suman Pathak, Seikh Mohammad Suhail, Syed Faizan
Diabetic nephropathy and peripheral neuropathy are the two main complications of chronic diabetes that contribute to high morbidity and mortality. These conditions are characterized by the dysregulation of multiple molecular signaling pathways and the presence of specific biomarkers such as inflammatory cytokines, indicators of oxidative stress, and components of the renin-angiotensin system. In this review, we systematically collected and collated the relevant information from MEDLINE, EMBASE, ELSEVIER, PUBMED, GOOGLE, WEB OF SCIENCE, and SCOPUS databases...
April 2024: Diabetology International
https://read.qxmd.com/read/38524629/prediction-of-immunotherapy-response-in-idiopathic-membranous-nephropathy-using-deep-learning-pathological-and-clinical-factors
#28
JOURNAL ARTICLE
Xuejiao Wei, Mengtuan Long, Zhongyu Fan, Yue Hou, Xiaoyu Zhu, Zhihui Qu, Yujun Du
BACKGROUND: Owing to individual heterogeneity, patients with idiopathic membranous nephropathy (IMN) exhibit varying sensitivities to immunotherapy. This study aimed to establish and validate a model incorporating pathological and clinical features using deep learning training to evaluate the response of patients with IMN to immunosuppressive therapy. METHODS: The 291 patients were randomly categorized into training (n = 219) and validation (n = 72) cohorts. Patch-level convolutional neural network training in a weakly supervised manner was utilized to analyze whole-slide histopathological features...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38523634/integrated-chemical-characterization-metabolite-profiling-and-pharmacokinetics-analysis-of-zhijun-tangshen-decoction-by-uplc-q-tof-ms
#29
JOURNAL ARTICLE
Qingheng Tong, Yueyue Chang, Guanxiong Shang, Jiu Yin, Xiaoqi Zhou, Suwei Wang, Xiaofeng Yan, Fangfang Zhang, Suqin Wang, Weifeng Yao
Diabetic nephropathy (DN) is the main cause of end-stage renal disease worldwide and a major public issue affecting the health of people. Therefore, it is essential to explore effective drugs for the treatment of DN. In this study, the traditional Chinese medicine (TCM) formula, Zhijun Tangshen Decoction (ZJTSD), a prescription modified from the classical formula Didang Decoction, has been used in the clinical treatment of DN. However, the chemical basis underlying the therapeutic effects of ZJTSD in treating DN remains unknown...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38523633/arachidonic-acid-metabolism-as-a-therapeutic-target-in-aki-to-ckd-transition
#30
REVIEW
Xiao-Jun Li, Ping Suo, Yan-Ni Wang, Liang Zou, Xiao-Li Nie, Ying-Yong Zhao, Hua Miao
Arachidonic acid (AA) is a main component of cell membrane lipids. AA is mainly metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP450). Esterified AA is hydrolysed by phospholipase A2 into a free form that is further metabolized by COX, LOX and CYP450 to a wide range of bioactive mediators, including prostaglandins, lipoxins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids. Increased mitochondrial oxidative stress is considered to be a central mechanism in the pathophysiology of the kidney...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38523631/jian-pi-gu-shen-hua-yu-decoction-alleviated-diabetic-nephropathy-in-mice-through-reducing-ferroptosis
#31
JOURNAL ARTICLE
Shuquan Lv, Lirong Fan, Xiaoting Chen, Xiuhai Su, Li Dong, Qinghai Wang, Yuansong Wang, Hui Zhang, Huantian Cui, Shufang Zhang, Lixin Wang
BACKGROUND: Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment of chronic kidney diseases such as DN, but the specific mechanism of action has not been fully elucidated yet. PURPOSE: The aim of this study is to clarify whether JPGS alleviates the progression of diabetic nephropathy by inhibiting ferroptosis...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38522145/nutrition-of-aging-people-with-diabetes-mellitus-focus-on-sarcopenia
#32
REVIEW
Almog Shalit, Eleni Gerontiti, Georgios Boutzios, Eleni Korakianiti, Fotini Kanouta, Vasiliki Vasileiou, Theodora Psaltopoulou, Stavroula A Paschou
As populations age, chronic diseases accumulate, and new health conditions emerge. One noteworthy pair that warrants further evaluation is diabetes mellitus and sarcopenia, given that the latter occurs in 28 % of the population aged over 50 who have diabetes mellitus. The management of both entails nutritional interventions, making the development of unified dietary recommendations an alluring strategy. This review aims to elucidate the current recommendations for the combined management of sarcopenia and diabetes, while featuring elements that require further research...
March 21, 2024: Maturitas
https://read.qxmd.com/read/38521428/the-effect-of-argania-spinosa-seed-oil-on-diabetic-nephropathy-in-streptozotocin-induced-diabetes-in-wistar-rats
#33
JOURNAL ARTICLE
Nour Elhouda Daoudi, Soufiane El Assri, Mohammed Aziz, Mohammed Choukri, Hassane Mekhfi, Abdelkhaleq Legssyer, Abderrahim Ziyyat, Mohamed Bnouham
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes is a significant metabolic disease impacting many of the world's population. In Morocco, a wide range of medicinal plants has taken great importance in the treatment of diabetes, among these plants; we find Argania spinosa (L.) Skeels. AIM: The objective of our work is based on the evaluation of the effect of roasted (Roil) and unroasted (UnRoil) Argan seed oil on diabetic nephropathy. MATERIALS AND METHODS: Roasted and unroasted oils from Argania spinosa (L...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38520630/copper-deficiency-anemia-due-to-zinc-supplementation-in-a-chronic-hemodialysis-patient
#34
JOURNAL ARTICLE
Tomoka Watanabe, Satomi Yonemoto, Yoshihiro Ikeda, Kiyotaka Kawaguchi, Tatsuo Tsukamoto
Zinc deficiency causes dysgeusia and dermatitis as well as anemia. As approximately half of dialysis patients have zinc deficiency, zinc supplementation should be considered in case of erythropoiesis-stimulating agent (ESA)-hyporesponsive anemia. We report a case of a chronic dialysis patient with copper deficiency anemia caused by standard-dose zinc supplementation. The patient was a 70-year-old woman who had received maintenance hemodialysis for 8 years due to diabetic nephropathy. She had been treated with weekly administration of darbepoetin 30 μg for renal anemia, which resulted in Hb 12 to 14 g/dL...
March 23, 2024: CEN Case Reports
https://read.qxmd.com/read/38520496/the-causal-effect-of-inflammatory-proteins-and-immune-cell-populations-on-diabetic-nephropathy-evidence-from-mendelian-randomization
#35
JOURNAL ARTICLE
Yi Ren, Honggang Zhang
BACKGROUND: Diabetic nephropathy (DN) is one of the diabetic microvascular complications with complex pathophysiology, and exploring the landscape of immune dysregulation in DN is valuable for pathogenesis and disease treatment. We crystallized possible inflammatory exposures into 91 circulating inflammatory proteins and 109 blood immune cells; and assessed the causal relationship between inflammation and DN using Mendelian randomization (MR). METHODS: Based on publicly available genetic data, we explored causal associations between inflammation and DN risk by two-sample MR analysis...
March 23, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38520226/lncrna-aa465934-improves-podocyte-injury-by-promoting-tristetraprolin-mediated-hmgb1-downregulation-in-diabetic-nephropathy
#36
JOURNAL ARTICLE
Nan Yang, Yue Zhang, Peiyao Ren, Li Zhao, Danna Zheng, Lanjun Fu, Juan Jin
Although LncRNA AA465934 expression is reduced in high glucose (HG)-treated podocytes, its role in HG-mediated podocyte injury and diabetic nephropathy (DN) remains unknown. Herein, we investigated the role of AA465934 in HG-mediated podocyte injury and DN using a spontaneous type II diabetic nephropathy (T2DN) model. The model was created by injecting AA465934 overexpressed adeno-associated virus (AAV) or control into mice. The levels of renal function, proteinuria, renal structural lesions, and podocyte apoptosis were then examined...
March 23, 2024: Molecular and Cellular Biology
https://read.qxmd.com/read/38518448/effect-of-dapagliflozin-on-collectins-and-complement-activation-in-plasma-from-patients-with-type-2-diabetes-and-albuminuria-data-from-the-dapkid-cohort
#37
JOURNAL ARTICLE
Mia Jensen, Mie K Eickhoff, Frederik Persson, Peter Rossing, Steffen Thiel, Søren W K Hansen, Yaseelan Palarasah, Per Svenningsen, Boye L Jensen
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT- 2) inhibitors exert cardiovascular and kidney-protective effects in people with diabetes. Attenuation of inflammation could be important for systemic protection. The lectin pathway of complement system activation is linked to diabetic nephropathy. We hypothesized that SGLT-2 inhibitors lower the circulating level of pattern-recognition molecules of the lectin cascade and attenuate systemic complement activation. METHODS: Analysis of paired plasma samples from the DapKid crossover intervention study where patients with type 2 diabetes mellitus (T2DM) and albuminuria were treated with dapagliflozin and placebo for 12 weeks (10 mg/day, n=36)...
March 15, 2024: Immunobiology
https://read.qxmd.com/read/38518164/association-of-thyroid-autoantibodies-with-diabetic-nephropathy-in-type-2-diabetes-mellitus-patients
#38
JOURNAL ARTICLE
Xia Chen, Mengyan Chen, Mengxia Chen, Mingxia Ji
BACKGROUND: Diabetic nephropathy (DN) is one of the most common and severe complications in patients with type 2 diabetes mellitus (T2DM). Thyroid dysfunction has been associated with diabetes and its complications but the relationship between thyroid autoantibodies and T2DM-DN remains unclear. OBJECTIVE: The study aims to investigate the association between thyroid autoantibodies and diabetic nephropathy in patients with T2DM and analyze the expression of serum thyroid hormone levels in T2DM-DN patients and its prognostic value...
March 22, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38516776/circular-rnas-and-the-regulation-of-gene-expression-in-diabetic-nephropathy-review
#39
JOURNAL ARTICLE
Maximo Berto Martinez Benitez, Yussel Pérez Navarro, Elisa Azuara-Liceaga, Angeles Tecalco Cruz, Jesús Valdés Flores, Lilia Lopez-Canovas
Circular RNAs (circRNAs) are non‑coding single‑stranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and post‑transcriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well as their role in cell processes associated with diabetic nephropathy...
May 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38513060/inorganic-nitrate-benefits-contrast-induced-nephropathy-after-coronary-angiography-for-acute-coronary-syndromes-the-nitrate-cin-trial
#40
JOURNAL ARTICLE
Daniel A Jones, Anne-Marie Beirne, Matthew Kelham, Lucinda Wynne, Mervyn Andiapen, Krishnaraj S Rathod, Tipparat Parakaw, Jessica Adams, Annastazia Learoyd, Kamran Khan, Thomas Godec, Paul Wright, Sotiris Antoniou, Andrew Wragg, Muhammad Yaqoob, Anthony Mathur, Amrita Ahluwalia
BACKGROUND AND AIMS: Contrast-induced nephropathy (CIN), also known as contrast-associated acute kidney injury (CA-AKI) underlies a significant proportion of the morbidity and mortality following coronary angiographic procedures in high-risk patients and remains a significant unmet need. In pre-clinical studies inorganic nitrate, which is chemically reduced in vivo to nitric oxide, is renoprotective but this observation is yet to be translated clinically. In this study, the efficacy of inorganic nitrate in the prevention of CIN in high-risk patients presenting with acute coronary syndromes (ACS) is reported...
March 21, 2024: European Heart Journal
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