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Diabetic nephropathy

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https://www.readbyqxmd.com/read/29909344/involvement-of-the-tgf%C3%AE-1-ilk-akt-signaling-pathway-in-the-effects-of-hesperidin-in-type-2-diabetic-nephropathy
#1
YingHui Zhang, Bing Wang, Feng Guo, ZhiZhen Li, GuiJun Qin
Diabetic nephropathy is one of the manifestations of systemic microangiopathy in diabetes. Hesperetin, a natural flavanone glycoside compound in citrus fruits, has been demonstrated to exert hypoglycemic effects and protect kidney in experimental diabetic animals. The current study was aimed to investigate the mechanisms underlying the hypoglycemic effects of hesperetin in high-fat/streptozocin (STZ)-induced diabetic nephropathy. The results showed that mice in whom hesperetin was administered for 4 weeks attenuated the increased fasting blood glucose and impaired glucose tolerance ability that was observed in high-fat/STZ mice...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29908543/t-helper-22-pathway-evaluation-in-type-1-diabetes-and-its-complications
#2
Hossein Akbari, Mostafa Ghardashi, Alireza Soleimani, Hanieh Mohammadi, Hassan Nikoueinejad
A subset of CD4+ T cells named T helper (Th)22 cells play some pathogenic roles in some autoimmune disorders such as type 1 diabetes (T1D). We aimed to study the correlation between the circulatory number of these cells and serum levels of its related cytokines with T1D as well as diabetic complications including metabolic control, atherosclerosis, and nephropathy. Fortynine patients with T1D and 43 healthy controls underwent the assessment of circulatory number of Th22 cells (by flow cytometry), serum level of Th22 related cytokines including Interleukin-22 (IL-22), Interleukin-10 (IL-10), Transforming growth factor-β (TGF-β), Tumor necrosis factor-α (TNF-α) (by ELISA) and carotid intima-media thickness (cIMT) measurement (by doppler ultrasonography)...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29907699/decline-in-kidney-function-among-apparently-healthy-young-adults-at-risk-of-mesoamerican-nephropathy
#3
Marvin Gonzalez-Quiroz, Evangelia-Theano Smpokou, Richard J Silverwood, Armando Camacho, Dorien Faber, Brenda La Rosa Garcia, Amin Oomatia, Michael Hill, Jason Glaser, Jennifer Le Blond, Catharina Wesseling, Aurora Aragon, Liam Smeeth, Neil Pearce, Dorothea Nitsch, Ben Caplin
Background Epidemic levels of CKD of undetermined cause, termed Mesoamerican nephropathy in Central America, have been found in low- and middle-income countries. We investigated the natural history of, and factors associated with, loss of kidney function in a population at high risk for this disease. Methods We conducted a 2-year prospective, longitudinal study with follow-up every 6 months in nine rural communities in northwestern Nicaragua and included all men ( n =263) and a random sample of women ( n =87) ages 18-30 years old without self-reported CKD, diabetes, or hypertension...
June 15, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29907545/differential-proteome-analysis-of-diabetes-mellitus-type-2-and-its-pathophysiological-complications
#4
REVIEW
Waleed Sohail, Fatimah Majeed, Amber Afroz
The prevalence of Diabetes Mellitus Type 2 (DM 2) is increasing every passing year due to some global changes in lifestyles of people. The exact underlying mechanisms of the progression of this disease are not yet known. However recent advances in the combined omics more particularly in proteomics and genomics have opened a gateway towards the understanding of predetermined genetic factors, progression, complications and treatment of this disease. Here we shall review the recent advances in proteomics that have led to an early and better diagnostic approaches in controlling DM 2 more importantly the comparison of structural and functional protein biomarkers that are modified in the diseased state...
June 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29904118/psoriasis-risk-in-patients-with-diabetic-retinopathy-a-nationwide-population-based-study
#5
Ji Hyun Lee, Ju Hee Han, Kyung Do Han, Young Min Park, Jun Young Lee, Yong-Gyu Park, Young Bok Lee
Psoriasis is a chronic cutaneous disease known to be related with systemic disease; however, the association between psoriasis and diabetic complications has not been previously reported. Diabetic microvascular complications include diabetic retinopathy (DR), nephropathy, and neuropathy, and overt diabetic nephropathy can lead to the end-stage renal disease (ESRD).The present study investigated the association between psoriasis and non-proliferative DR (NPDR) or proliferative DR (PDR) or ESRD. We analyzed the relationship between diabetic complication and psoriasis using data from the National Health Insurance Service between 2009 and 2015...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29904053/naoxintong-capsules-inhibit-the-development-of-diabetic-nephropathy-in-db-db-mice
#6
Shu Yang, Mengyang Liu, Yuanli Chen, Chuanrui Ma, Lipei Liu, Buchang Zhao, Yong Wang, Xiaoju Li, Yan Zhu, Xiumei Gao, Deling Kong, Yajun Duan, Jihong Han, Xiaoxiao Yang
NaoXinTong Capsule (NXT), a Chinese medicine, is currently used to treat patients with cardiovascular and cerebrovascular diseases. Clinical observations indicate its anti-diabetic functions with unclear mechanisms. Herein, we report the effect of NXT on diabetic nephropathy (DN). Type 2 diabetic db/db mice were treated with NXT for 14 weeks. In the course of treatment, NXT reduced diabetes-increased glucose levels and improved renal functions. At the end of treatment, we found that NXT ameliorated serum lipid profiles and other biochemical parameters...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29901140/spleen-tyrosine-kinase-promotes-nlr-family-pyrin-domain-containing-3-inflammasome%C3%A2-mediated-il%C3%A2-1%C3%AE-secretion-via-c%C3%A2-jun-n%C3%A2-terminal-kinase-activation-and-cell-apoptosis-during-diabetic-nephropathy
#7
Yingchun Qiao, Xixi Tian, Li Men, Shengyu Li, Yufeng Chen, Meiting Xue, Yahui Hu, Pengfei Zhou, Guangfeng Long, Yue Shi, Ruiqing Liu, Yunde Liu, Zhi Qi, Yujie Cui, Yanna Shen
Diabetic nephropathy (DN) is a serious complication of diabetes and can cause an increased mortality risk. It was previously reported that NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in the pathogenesis of diabetes. However, the underlying mechanism is not clearly understood. In the present study, the effects of spleen tyrosine kinase (Syk) and c‑Jun N‑terminal kinase (JNK) on the NLRP3 inflammasome were examined in vivo and in vitro. Sprague‑Dawley rats were injected intraperitoneally with streptozotocin (65 mg/kg) to induce diabetes...
June 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901130/grape-seed-proanthocyanidins-protect-against-streptozotocin%C3%A2-induced-diabetic-nephropathy-by-attenuating-endoplasmic-reticulum-stress%C3%A2-induced-apoptosis
#8
Zhaoli Gao, Guangyi Liu, Zhao Hu, Weiwei Shi, Binbin Chen, Peimei Zou, Xianhua Li
Diabetic nephropathy (DN) is by far the most common cause of end‑stage renal disease (ESRD) in industrial countries, accounting for ~45% of all new ESRD cases in the United States. Grape seed proanthocyanidin extracts (GSPE) are powerful antioxidants, with an antioxidant ability 50‑fold greater than that of vitamin E and 20‑fold greater than that of vitamin C. The present study investigated whether GSPE can protect against streptozotocin (STZ)‑induced DN and aimed to elucidate a possible mechanism...
June 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901095/loss-of-klf15-accelerates-chronic-podocyte-injury
#9
Seung Seok Han, Mi-Yeon Yu, Kyung Don Yoo, Jung Pyo Lee, Dong Ki Kim, Yon Su Kim, Seung Hee Yang
Krüppel‑like factor 15 (KLF15), also known as kidney‑enriched transcription factor, is known to participate in podocyte differentiation. However, the role of KLF15 in chronic podocyte injury remains incompletely understood, particularly in proteinuric disease models. In the present study, the 5/6 nephrectomy mouse model was used to induce chronic podocyte injury. Human primary podocytes were isolated by flow cytometry and cultured to emulate the injury process in an in vitro system. Biopsied kidney tissue samples were obtained from patients with primary membranous nephropathy or diabetic nephropathy in order to analyze the relationship between glomerular KLF15 expression and subsequent outcomes...
June 11, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29899045/-apol1-nephropathy-risk-variants-and-incident-cardiovascular-disease-events-in-community-dwelling-black-adults
#10
Orlando M Gutiérrez, Marguerite R Irvin, Ninad S Chaudhary, Mary Cushman, Neil A Zakai, Victor A David, Sophie Limou, Nathalie Pamir, Alex P Reiner, Rakhi P Naik, Michele M Sale, Monika M Safford, Hyacinth I Hyacinth, Suzanne E Judd, Jeffrey B Kopp, Cheryl A Winkler
BACKGROUND: APOL1 renal risk variants are strongly associated with chronic kidney disease in Black adults, but reported associations with cardiovascular disease (CVD) have been conflicting. METHODS: We examined associations of APOL1 with incident coronary heart disease (n=323), ischemic stroke (n=331), and the composite CVD outcome (n=500) in 10 605 Black participants of the REGARDS study (Reasons for Geographic and Racial Differences in Stroke). Primary analyses compared individuals with APOL1 high-risk genotypes to APOL1 low-risk genotypes in Cox proportional hazards models adjusted for CVD risk factors and African ancestry...
June 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29896981/astragaloside-iv-ameliorates-early-diabetic-nephropathy-by-inhibition-of-mek1-2-erk1-2-rsk2-signaling-in-streptozotocin-induced-diabetic-mice
#11
Gaofeng Song, Pengxun Han, Huili Sun, Mumin Shao, Xuewen Yu, Wenjing Wang, Dongtao Wang, Wuyong Yi, Na Ge, Shunmin Li, Tiegang Yi
Objective The aim of this study was to investigate the renoprotective effects and molecular mechanisms of astragaloside IV (AS-IV) in streptozotocin (STZ)-induced diabetic mice. Methods Male C57BL/6 mice were injected intraperitoneally with STZ at 200 mg/kg body weight. AS-IV was administered for 8 consecutive weeks, beginning 1 week after STZ injection. Body weight, 24-hour urinary albumin excretion, and fasting blood glucose were measured. Kidney tissues were examined by histopathological analyses. Total levels and phosphorylation of mitogen-activated protein kinase 1/2 (MEK1/2), extracellular signal-regulated kinases 1 and 2 (ERK1/2), and ribosomal S6 kinase 2 (RSK2) were determined by Western blotting analysis...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29896720/stem-cell-therapy-and-type-1-diabetes-mellitus-treatment-strategies-and-future-perspectives
#12
Tahir Farooq, Kanwal Rehman, Arruje Hameed, Muhammad Sajid Hamid Akash
Type 1 diabetes mellitus (T1DM) is classified as an autoimmune disease which progressively results in the depletion of insulin-secreting β-cells. Consequently, the insulin secretion stops leading to hyperglycemic situations within the body. Under severe conditions, it also causes multi-organ diabetes-associated dysfunctionalities notably hypercoagulability, neuropathy, nephropathy, retinopathy, and sometimes organ failures. The prevalence of this disease has been noticed about 3% that has highlighted the serious concerns for healthcare professionals around the globe...
June 13, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29896264/effects-of-hyperglycaemia-and-elevated-glycosylated-haemoglobin-on-contrast-induced-nephropathy-after-coronary-angiography
#13
Yu-Han Qin, Gao-Liang Yan, Chang-Le Ma, Cheng-Chun Tang, Gen-Shan Ma
In patients undergoing percutaneous coronary intervention after acute myocardial infarction, hyperglycaemia on admission is associated with an increased risk of contrast-induced nephropathy (CIN). However, the effects of hyperglycaemia and elevated glycosylated haemoglobin (HbA1c) on CIN have remained to be fully elucidated. Therefore, a prospective cohort study was performed, comprising 258 patients who underwent coronary angiography between May 2017 and November 2017 at Zhongda Hospital affiliated with Southeast University (Nanjing, China)...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895977/immunoregulatory-mechanisms-of-mesenchymal-stem-and-stromal-cells-in-inflammatory-diseases
#14
REVIEW
Yufang Shi, Yu Wang, Qing Li, Keli Liu, Jianquan Hou, Changshun Shao, Ying Wang
Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have attracted much attention for their ability to regulate inflammatory processes. Their therapeutic potential is currently being investigated in various degenerative and inflammatory disorders such as Crohn's disease, graft-versus-host disease, diabetic nephropathy and organ fibrosis. The mechanisms by which MSCs exert their therapeutic effects are multifaceted, but in general, these cells are thought to enable damaged tissues to form a balanced inflammatory and regenerative microenvironment in the presence of vigorous inflammation...
June 12, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29895032/different-doses-of-tripterygium-glycosides-in-the-treatment-of-diabetic-nephropathy-effects-on-blood-lipids
#15
Wei Wang
BACKGROUND/AIMS: The aim of this study was to investigate the therapeutic effect of different doses of tripterygium glycosides (TG) in the treatment of diabetic nephropathy (DN). The effect of TG on blood lipids and safety were also evaluated. METHODS: Sixty patients with type 2 DN were randomly divided into three groups (n=20 per group): low-dose (30 mg/day TG), double-dose (60 mg/day TG) and control (placebo) groups, all three times daily for 6 months. The levels of triglycerides, total cholesterol, urinary protein, plasma albumin and serum tumour necrosis factor (TNF)-α were compared between the three groups...
June 7, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29893142/microangiopathy-is-associated-with-bone-loss-in-female-type-2-diabetes-mellitus-patients
#16
Ni Zhong, Youyang Zhang, Xiangling Pu, Bei Xu, Mingxin Xu, Haidong Cai, Ge Zhang, Ran Cui, Hui Sheng, Shen Qu
OBJECTIVE: Type 2 diabetes mellitus complicated with microvascular diseases can be used as a model to study the relationship between bone health and the microvascular situation. METHODS: A total of 2,170 patients with type 2 diabetes mellitus (1,188 postmenopausal females and 982 males aged ⩾50 years) were included in our cross-sectional study. These patients were grouped according to 24-hour urine protein level: Group I (<30 mg), Group II (30-299 mg) and Group III (≥300 mg)...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29892340/declining-trends-of-diabetic-nephropathy-retinopathy-and-neuropathy-with-improving-diabetes-care-indicators-in-japanese-patients-with-type-2-and-type-1-diabetes-jddm-46
#17
Hiroki Yokoyama, Shin-Ichi Araki, Koichi Kawai, Katsuya Yamazaki, Osamu Tomonaga, Shin-Ichiro Shirabe, Hiroshi Maegawa
Objective: We examined changes in prevalence of diabetic microvascular/macrovascular complications and diabetes care indicators for adults in Japan with type 2 and type 1 diabetes over one decade. Research design and methods: Two independent cohorts were recruited with the same inclusion criteria in 2004 (cohort 1: 3319 with type 2 and 286 with type 1 diabetes) and in 2014 (cohort 2: 3932 with type 2 and 308 with type 1 diabetes). Prevalence of complications and care indicators including achieving treatment targets for glycemia, blood pressure, lipid control, body mass index (BMI), and smoking were compared...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29891746/correlation-between-circulating-visfatin-and-nitric-oxide-metabolites-levels-in-patients-with-diabetic-nephropathy
#18
Naghmeh Akbarian, Nosratollah Zarghami, Ali Mota, Sima Abediazar, Sina Abroon, Aynaz Mihanfar, Mina Amanzadeh, Akbar Darbin, Hossein Bannazadeh Baghi, Mohammad Rahmati-Yamchi
INTRODUCTION: Diabetic nephropathy is one of the serious complications of diabetes mellitus. Visfatin is an intracellular enzyme with insulin-mimicking effects. It enhances the expression of endothelial nitric oxide (NO) synthase in renal cells. This study aimed to investigate serum levels of visfatin and NO metabolites in patients with diabetic nephropathy. MATERIALS AND METHODS: A total of 80 diabetic patients were enrolled and classified into nephropathic and non-nephropathic patients...
May 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29891745/effects-of-high-dose-vitamin-e-supplementation-on-markers-of-cardiometabolic-risk-and-oxidative-stress-in-patients-with-diabetic-nephropathy-a-randomized-double-blinded-controlled-trial
#19
Esmat Aghadavod, Alireza Soleimani, Gholamali Hamidi, Fariba Keneshlou, Akbar Heidari, Zatollah Asemi
INTRODUCTION: Patients with diabetic nephropathy (DN) may benefit from vitamin E's antilipid and antioxidant activities. This study aimed to evaluate the effects of high-dose vitamin E supplementation on markers of cardiometabolic risk and oxidative stress in patients with DN. MATERIALS AND METHODS: This randomized controlled trial was carried out on 54 patients with DN that were randomly divided into 2 groups to receive vitamin E supplement (800 IU/d) or placebo for 12 weeks...
May 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29891743/insulin-receptor-substrate-2-mrna-expression-in-urinary-sediment-cells-as-a-diagnostic-marker-of-nephropathy-in-diabetic-patients
#20
Mahdieh Salimi, Sepehr Sarrafzadeh Zargar
INTRODUCTION: The initiation and progression of diabetic nephropathy (DN) is complex. Quantification of mRNA expression in urinary sediment cells (USCs) has emerged as a novel strategy for studying kidney diseases. Insulin requires a family of insulin receptor substrate (IRS) proteins for its physiological effects, and many reports have highlighted the role of insulin and IRS proteins in kidney physiology and disease. This study aimed to assess IRS2 expression in USCs of patients with diabetes mellitus, DN, and nondiabetic chronic kidney disease...
May 2018: Iranian Journal of Kidney Diseases
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