Md Faruque Ahmad, Fakhruddin Ali Ahmad, Nazim Hasan, Abdulrahman A Alsayegh, Othman Hakami, Farkad Bantun, Shadma Tasneem, Waleed M Alamie, Ahmad O Babalghith, Abdullah F Aldairi, Nahla Kambal, Ehab Y Elbendary
Diabetes is a chronic metabolic disorder. Diabetes complications can affect many organs and systems in the body. Ganoderma lucidum (G. lucidum) contains various compounds that have been studied for their potential antidiabetic effects, including polysaccharides, triterpenoids (ganoderic acids, ganoderol B), proteoglycans, and G. lucidum extracts. G. lucidum polysaccharides (GLPs) and triterpenoids have been shown to act through distinct mechanisms, such as improving glucose metabolism, modulating the mitogen-activated protein kinase (MAPK) system, inhibiting the nuclear factor-kappa B (NF-κB) pathway, and protecting the pancreatic beta cells...
April 18, 2024: International Journal of Biological Macromolecules