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Diabetic nephropathy

Rabia Nabi, Sahir Sultan Alvi, Mohd Saeed, Saheem Ahmad, M Salman Khan
INTRODUCTION: Diabetes mellitus (DM) acts as an absolute mediator of cardiovascular risk, prompting the prolonged occurrence, size and intricacy of atherosclerotic plaques via enhanced advanced glycation endproducts (AGEs) formation. Moreover, hyperglycemia is associated with enhanced glyco-oxidized and oxidized low-density lipoprotein (LDL) possessing greater atherogenicity and decreased ability to regulate HMG-CoA reductase (HMG-R). Although aminoguanidine (AG) prevents the AGE-induced protein cross-linking due to its anti-glycation potential, it exerts several unusual pharmaco-toxicological effects thus restraining its desirable therapeutic effects...
September 24, 2018: Current Diabetes Reviews
Kamran Mahmood Ahmed Aziz
INTRODUCTION: In research elevated blood pressure (BP) has been demonstrated to be a risk for the development of nephropathy and chronic renal disease (CKD) or diabetic kidney disease(DKD) among diabetics. However, no study has find correlation for the spot urine protein (UPr) excretion with elevated BP, pulse pressure (PP) and mean arterial pressure MAP). This technique was invented in the current study. 10,270 were recruited for more than 12 years. Demographically, 43% , 38%, and 16% showed hypertension, nephropathy and chronic renal disease, respectively...
September 24, 2018: Current Diabetes Reviews
Dorota Raczynska, Beata Bzoma, Katarzyna Sielachowicz, Agnieszka Brandt, Dorota Chominska-Dorn, Krystyna Raczynska, Leopold Glasner, Alicja Debska-Slizien, Malgorzata Mysliwiec
AIM: Estimation of the ocular status in adolescents with diabetes mellitus type 1 (DM1) treated with continuous subcutaneous insulin infusion (CSII), assessment of the development of the diabetic retinopathy (DR) and nephropathy (DN) within 10 years. METHODS: 37 patients (74 eyes) aged 16-33 years, treated with CSII were enrolled to the study. Baseline, and a 10-year follow-up evaluation, included: best corrected visual acuity (BCVA), tonometry, slit lamp exam and fluorescein angiography (FLA)...
September 24, 2018: Current Pharmaceutical Design
Qingqing Chen, Yong Su, Yinghui Ju, Keke Ma, Weizu Li, Weiping Li
Renal tubular injury is associated with the development of diabetic nephropathy (DN) and the end-stage renal disease (ESRD). Free fatty acids (FFAs)-associated lipotoxicity contributes to injury of proximal renal tubular epithelial (HK-2) cells in diabetes. Palmitic acid (PA) which is the most abundant saturated fatty acid in FFAs is closely associated with the gradual decline of renal function. Astragalosides IV (AS-IV) has a variety of pharmacological effects such as anti-inflammation and anti-oxidation. In the current study, we investigated the effects of AS-IV on PA-induced apoptosis of HK-2 cells and the underlying mechanisms...
September 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yuxiang Xu, Jiuzhi Zhang, Li Fan, Xiaowen He
Podocyte injury plays crucial roles in the pathogenesis of diabetic nephropathy (DN). Aberrant microRNAs (miRNAs) have been suggested to contribute to podocyte injury. However, whether miR-423-5p could alleviate high glucose (HG)-mediated podocyte injury and the underlying mechanisms remains unclear. In this study, we found that patients with DN have reduced miR-423-5p and elevated Nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) expressions in clinical renal tissues, and HG induced Nox4 but suppressed miR-423-5p expressions in cultured podocytes in a time-dependent manner...
September 21, 2018: Biochemical and Biophysical Research Communications
Zi-Jun Sun, Xiao-Qian Li, Dong-Yuan Chang, Su-Xia Wang, Gang Liu, Min Chen, Ming-Hui Zhao
AIMS: - As the potential role of the complement system in diabetic nephropathy (DN) is increasingly reported, this study aimed to investigate C1q and C3c deposition as seen on renal histopathology, as well as its association with clinical and pathological parameters, in DN patients. METHODS: - Renal biopsy specimens from 161 DN patients were investigated using direct immunofluorescence and light and electron microscopy. For direct immunofluorescence, staining for C1q and C3c on fresh-frozen renal tissue was performed immediately after biopsy...
September 19, 2018: Diabetes & Metabolism
Entsar R Mokhtar, Eman M, Maha A Hassan, Hanaa A Abou-ELHassan, Mona G Alanany, Mohammed A Hasuna
Renal dysfunction is a key risk factor for all-cause mortality in patients with type 2 diabetes (T2D). Special attention has been raised regarding the role of soluble tumor necrosis factor receptor1 (sTNFR1) and brain natriuretic peptide (BNP) in diabetic nephropathy (DN) since they play a crucial role in the pathogenesis of T2D complications. Elevated concentrations of sTNFR1and BNP were found to be associated with progression to end stage renal disease (ESRD) in T2D. We determined serum levels of sTNFR1 and BNP in T2D patients and correlated them with various clinical variables especially kidney function and urinary albumin creatinine ratio (UACR)...
January 2018: Egyptian Journal of Immunology
Zhang-Ren Chen, Fa-Zhong He, Mou-Ze Liu, Jin-Lei Hu, Heng Xu, Hong-Hao Zhou, Wei Zhang
PURPOSE: Diabetes mellitus is a major chronic disease and causes over one million deaths. KCNJ11 genetic polymorphisms influence the response of first-line oral antidiabetic agent sulfonylureas. Hsa-miR-4532 correlates with diabetic nephropathy and has a high abundance in urine. MIR4532 rs60452575 G>A variant changes the mature sequence of hsa-miR-4532. We studied whether the genetic polymorphisms of MIR4532 rs60452575 would influence KCNJ11 expression and sulfonylurea-stimulated insulin secretion or not...
September 21, 2018: Endocrine
Aline Cristina Luz, Márcio Galvão de Oliveira, Lúcia Noblat
Background Potentially inappropriate prescribing for older people has become a global concern, although few researchers have analyzed potential prescribing omissions for this population. Objective This study aimed to compare the frequency of potential prescribing omissions for elderly patients at their admission to and discharge from a university hospital in northeast Brazil, using the validated and adapted Brazilian START criteria. Setting A university hospital in northeast Brazil. Methods This cross-sectional study examined data from patients who were ≥ 60 years old when they were admitted for > 24 h to a northeastern Brazil teaching hospital during June-December 2016...
September 22, 2018: International Journal of Clinical Pharmacy
Jing-Min Zheng, Zuan-Hong Jiang, De-Jun Chen, Sa-Sa Wang, Wen-Jin Zhao, Li-Juan Li
AIMS: The aim of this study was to get a full view of the changes of urinary complement activation products in the development of diabetic nephropathy and explore their possible significance in the disease process. MATERIALS AND METHODS: Sixty-two patients at different stages of diabetic nephropathy,20 diabetes patients without nephropathy and 20 healthy persons were enrolled. Urinary complement activation products including C3a, C5a and C5b-9 were measured and their associations with the progression of the disease were analyzed...
September 21, 2018: Journal of Diabetes Investigation
Yunqiang He, Mei Zhang, Ying Wu, Hemin Jiang, Hongxing Fu, Yong Cai, Ziqiang Xu, Chengyang Liu, Bicheng Chen, Tao Yang
Signaling abnormalities play important roles during podocyte injury and have been indicated as crucial events for triggering many glomerular diseases. There is emerging evidence demonstrating significant improvements in preventing renal injury and restoring podocytes after islet transplantation. However, whether signaling abnormalities affect the therapeutic efficacy of islet transplantation remain unclear. This study was established to investigate the impact of Notch-1 signaling activation on renal injury and podocyte restoration after islet transplantation...
September 20, 2018: Cell Death & Disease
Mohammad Taghi Najafi, Pegah Khaloo, Hamid Alemi, Asma Jaafarinia, Michael J Blaha, Mohammadhassan Mirbolouk, Mohammad Ali Mansournia, Mohsen Afarideh, Sadaf Esteghamati, Manouchehr Nakhjavani, Alireza Esteghamati
Ambulatory blood pressure monitoring (ABPM) correlates more closely to organ damages than clinic blood pressure (BP). In the current study we aimed to investigate the association between micro- and macrovascular complications of diabetes and both diurnal and nocturnal variability in BP.A total of 192 patients with type 2 diabetes (T2DM) who had complete data on ABPM were selected. BP categories were defined based on 2017 ACC/American Heart Association BP guideline. The cross-sectional association between different BP phenotypes and diabetes complications including cardiovascular disease (CVD), nephropathy, retinopathy, and neuropathy was assessed using multiple logistic regression models adjusted for age, sex, body mass index, hypertension (HTN), hemoglobin A1c, fasting blood glucose (FBG), triglyceride (TG), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total cholesterol...
September 2018: Medicine (Baltimore)
Yuejiang Jiao, Hongwei Jiang, Haibo Lu, Yiping Yang, Yanfang Zhang, Kun Zhang, Hui Liu
The present study was designed to investigate the effect of hypoxia inducible factor-1α (HIF-1α) on diabetic nephropathy (DN) with hypertension. HIF-1α deficient mice (Mx/HIF-1α-/- ) were constructed and treated with streptozotocin (STZ) injection for hypertensive DN induction. Normal C57BL/6 mice received STZ or no treatment (normal) were considered as controls. Three days post STZ administration; body weight, fasting blood glucose (FBG), 24 h urinary albumin and systolic blood pressure (SBP) were measured weekly...
October 2018: Experimental and Therapeutic Medicine
Jie-Ming Nie, Hai-Feng Li
Involvement of collagen IV (ColIV) and fibronectin (FN) in the occurrence and development of diabetic nephropathy (DN) and the effects of telmisartan and Salvia miltiorrhiza injection in the treatment of the patients were investigated. Two hundred and fifty-eight patients with stage IV DN were selected as the case group, and another 110 normal healthy subjects were incorporated as the control group. Involved patients were subdivided into different groups according to different treatment therapies; patients in the telmisartan group (T group) were given oral telmisartan; patients in the Salvia miltiorrhiza injection + telmisartan (S + T group) were administered with Salvia miltiorrhiza injection combined with telmisartan treatment, and there was a group of patients who received no intervention as the placebo group...
October 2018: Experimental and Therapeutic Medicine
Xiao Lei, Limei Zhang, Zonglin Li, Jigang Ren
Objective: This study aims to figure out the mechanism of astragaloside IV (AS-IV) in the protection of podocyte apoptosis in diabetic nephropathy (DN) rats. Materials and methods: Streptozotocin (STZ) was used to induce diabetes in rats, and the diabetic rats were treated with 5 mg/kg/d of AS-IV for 12 weeks. Albuminuria level, relative TUG1 and TRAF5 levels, and TRAF5 and cleaved-caspase-3 protein levels were examined by ELISA, quantitative reverse transcription (qRT)-PCR, and Western blot analyses, respectively...
2018: Drug Design, Development and Therapy
Nestor Oliva-Damaso, Eduardo Baamonde-Laborda, Elena Oliva-Damaso, Juan Payan, Alberto Marañes, Nicanor Vega-Diaz, Jose Carlos Rodriguez-Perez
INTRODUCTION: Low pre-hemodialysis (pre-HD) serum sodium or hyponatremia is associated with higher mortality. Pre-HD serum sodium can be more stable over time with low fluctuation compared to other serum parameters. MATERIALS AND METHODS: We examined variation of pre-HD serum sodium in 24 months and after this point examined all-cause mortality in a cohort of 261 patients followed-up for 48.8 (standard deviation (SD) = 19.1) months. 6,221 determinations of pre-HD serum sodium were made and corrected for glucose concentrations...
September 20, 2018: Clinical Nephrology
Deng Yunlei, Fan Qiuling, Wang Xu, Zhao Qianwen, Cao Xu, Xu Li, Wang Lining
BACKGROUND/AIMS: Diabetic nephropathy is the one of the most serious microvascular complications of diabetes mellitus, and "metabolic memory" plays a vital role in the development of diabetic complications. To investigate the effect of epigenetics on metabolic memory, we analyzed the impact of transient high-glucose stimulation on the secretion of inflammatory factors from rat glomerular mesangial cells. METHODS: Rat glomerular mesangial cells (HBZY-1) were divided into three groups: high-glucose group (25 mM glucose), hypertonic group (5...
September 19, 2018: Cellular Physiology and Biochemistry
Markus M Rinschen, Pitter F Huesgen, Rachelle E Koch
Proteases regulate glomerular physiology. The last decade has revealed a multitude of podocyte proteases that govern the glomerular response to numerous chemical, mechanical and metabolic cues. These proteases form a protein signaling web that integrates stress stimuli and serves as a key controller of the glomerular microenvironment. Both the extracellular and intracellular proteolytic networks are perturbed in focal segmental glomerulosclerosis, as well as hypertensive and diabetic nephropathy. Accordingly, the highly-intertwined podocyte protease web is an integrative part of the podocyte's damage response...
September 19, 2018: American Journal of Physiology. Renal Physiology
Amrish Krishnan, Yogeshni Chandra, Joji Malani, Shilpanjali Jesudason, Shaundeep Sen, Angus G Ritchie
BACKGROUND: Chronic kidney disease is now a leading cause of death in Fiji. The country lacks even basic statistics about the incidence of end stage kidney disease (ESKD) and presents significant challenges to conducting clinical research. AIM: To estimate the incidence and characteristics of ESKD in Fijian adults. METHODS: A retrospective cohort study was conducted of patients admitted to Colonial War Memorial Hospital in Suva, Fiji in 2012...
September 19, 2018: Internal Medicine Journal
Z-M Liu, H-Y Zheng, L-H Chen, Y-L Li, Q Wang, C-F Liao, X-W Li
OBJECTIVE: To investigate the relationship between microRNA-203 (miR-203) and diabetic nephropathy and its potential mechanism. MATERIALS AND METHODS: The expression of microRNA-203 in mice with diabetic nephropathy and M4200 cells cultured with high glucose was detected by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Toll-like receptor 4 (TLR4), the target gene of microRNA-203, was predicted and screened by bioinformatics method. Real-time quantitative PCR and Western blot were used to detect the endogenous TLR4 level in renal cortex of db/db mice with diabetic nephropathy and glomerular mesangial cells cultured in high glucose or low glucose...
September 2018: European Review for Medical and Pharmacological Sciences
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