keyword
https://read.qxmd.com/read/38488455/salidroside-directly-activates-hsc70-revealing-a-new-role-for-hsc70-in-bdnf-signalling-and-neurogenesis-after-cerebral-ischemia
#21
JOURNAL ARTICLE
Wenfang Lai, Rui Luo, Yuheng Tang, Zhengshuang Yu, Binbin Zhou, Zelin Yang, John Brown, Guizhu Hong
Salidroside, a principal bioactive component of Rhodiola crenulata, is neuroprotective across a wide time window in stroke models. We investigated whether salidroside induced neurogenesis after cerebral ischemia and aimed to identify its primary molecular targets. Rats, subjected to transient 2 h of middle cerebral artery occlusion (MCAO), received intraperitoneal vehicle or salidroside ± intracerebroventricular HSC70 inhibitor VER155008 or TrkB inhibitor ANA-12 for up to 7 days. MRI, behavioural tests, immunofluorescent staining and western blotting measured effects of salidroside...
March 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38488442/erucin-a-natural-isothiocyanate-exerts-pro-angiogenic-properties-in-cultured-endothelial-cells-and-reverts-angiogenic-impairment-induced-by-high-glucose
#22
JOURNAL ARTICLE
Shirley Genah, Valerio Ciccone, Arianna Filippelli, Vittoria Simonis, Alma Martelli, Eugenia Piragine, Eleonora Pagnotta, Nicola Pecchioni, Vincenzo Calderone, Lucia Morbidelli
Insufficient vessel maintenance adversely impacts patients in terms of tissue reperfusion following stroke or myocardial infarction, as well as during wound healing. Angiogenesis impairment is a feature typical of metabolic disorders acting at the cardiovascular level, such as diabetes. Therapeutic angiogenesis regulation offers promising clinical implications, and natural compounds as pro-angiogenic nutraceuticals hold valuable applications in regenerative medicine. By using cultured endothelial cells from human umbilical veins (HUVEC) we studied functional and molecular responses following exposure to erucin, a natural isothiocyanate derived from Brassicaceae plants and extracted from the seeds of rocket...
March 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38487990/kaempferitrin-attenuates-unilateral-ureteral-obstruction-induced-renal-inflammation-and-fibrosis-in-mice-by-inhibiting-nox4-mediated-tubular-ferroptosis
#23
JOURNAL ARTICLE
Jianchun Li, Jieke Yang, Qianwen Xian, Hongwei Su, Yufang Ni, Li Wang
Tubular ferroptosis significantly contributes to renal inflammation and fibrosis, critical factors in chronic kidney disease (CKD). This study aims to investigate Kaempferitrin, a potent flavonoid glycoside from Bauhinia forficata leaves, renowned for its anti-inflammatory and antitumor effects, and to elucidate its potential mechanisms in mitigating inflammation and fibrosis induced by tubular ferroptosis. The study investigated Kaempferitrin's impact on tubular ferroptosis using a unilateral ureteral obstruction (UUO) model-induced renal inflammation and fibrosis...
March 15, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38486266/harmony-in-nature-understanding-the-cultural-and-ecological-aspects-of-plant-use-in-ladakh
#24
JOURNAL ARTICLE
Kunzes Angmo, Bhupendra S Adhikari, Rainer W Bussmann, Gopal S Rawat
BACKGROUND: Traditional knowledge (TK) in Ladakh encapsulates a repository of experimental wisdom cultivated over millennia. Despite this cultural wealth, dwindling interest among the younger generations in the region's age-old practices underscores the urgency to document TK. The current study investigates the diverse usage of plants in Surru, Wakha and Lower Indus valleys of Western Ladakh exploring the influence of socioeconomic and ecological factors. METHODS: A stratified random sample approach was adopted to select 540 respondents for gathering information of useful plants through interviews and questionnaires...
March 14, 2024: Journal of Ethnobiology and Ethnomedicine
https://read.qxmd.com/read/38486237/different-divergence-processes-of-isoglosses-of-folk-nomenclature-between-wild-trees-and-rice-landraces-imply-the-need-for-different-conservation-planning-based-on-the-type-of-plant-resources
#25
JOURNAL ARTICLE
Yoshinori Tokuoka, Mincheol Seo, Hiroshi Hayakawa, Fukuhiro Yamasaki, Kenichiro Kimura, Kenji Takashima, Kiyokazu Hashigoe, Hiromitsu Matsui, Mitsunori Oka
BACKGROUND: The intensification of production and socio-economic changes have accelerated the loss of local traditional knowledge and plant resources. Understanding the distribution and determinants of such biocultural diversity is essential in planning efficient surveys and conservation efforts. Because the concept of biocultural diversity in socio-ecological adaptive systems comprises biological, cultural, and linguistic diversity, linguistic information should serve as a surrogate for the distribution of local biological and cultural diversity...
March 14, 2024: Journal of Ethnobiology and Ethnomedicine
https://read.qxmd.com/read/38479376/effect-and-mechanism-of-quercetin-or-quercetin-containing-formulas-against-covid-19-from-bench-to-bedside
#26
REVIEW
Jhong Yuan Chen, Tsung Rung Huang, Shih Yun Hsu, Ching Chun Huang, Huei Syun Wang, Jung San Chang
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global coronavirus disease 2019 (COVID-19) pandemic since 2019. Immunopathogenesis and thromboembolic events are central to its pathogenesis. Quercetin exhibits several beneficial activities against COVID-19, including antiviral, anti-inflammatory, immunomodulatory, antioxidative, and antithrombotic effects. Although several reviews have been published, these reviews are incomplete from the viewpoint of translational medicine. The authors comprehensively evaluated the evidence of quercetin against COVID-19, both basically and clinically, to apply quercetin and/or its derivatives in the future...
March 13, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38475999/effects-of-silymarin-supplementation-on-liver-and-kidney-functions-a-systematic-review-and-dose-response-meta-analysis
#27
REVIEW
Shooka Mohammadi, Damoon Ashtary-Larky, Omid Asbaghi, Vida Farrokhi, Yasaman Jadidi, Fatemeh Mofidi, Mehrnaz Mohammadian, Reza Afrisham
It is suggested that supplementation with silymarin (SIL) has beneficial impacts on kidney and liver functions. This systematic review and dose-response meta-analysis assessed the impact of SIL administration on certain hepatic, renal, and oxidative stress markers. A systematic search was conducted in various databases to identify relevant trials published until January 2023. Randomized controlled trials (RCTs) that evaluated the effects of SIL on kidney and liver markers were included. A random-effects model was used for the analysis and 41 RCTs were included...
March 12, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38475780/saving-the-local-tradition-ethnobotanical-survey-on-the-use-of-plants-in-bologna-district-italy
#28
JOURNAL ARTICLE
Ilaria Chiocchio, Lorenzo Marincich, Manuela Mandrone, Simona Trincia, Clarissa Tarozzi, Ferruccio Poli
BACKGROUND: Traditional knowledge about plants is unfortunately subjected to a progressive loss, mainly due to globalization and depopulation of the rural areas. This work enhances the ethnobotanical knowledge from Northern Italy, specifically Bologna district, and contributes to preserving Italy's plant-based traditional knowledge and to valorize local resources also in view of an ecological transition. METHODS: The study was conducted between 2010 and 2016 in Bologna district encompassing 22 municipalities, which were grouped into three areas: hill, mountain, and plain...
March 12, 2024: Journal of Ethnobiology and Ethnomedicine
https://read.qxmd.com/read/38472670/utilisation-of-indigenous-knowledge-to-control-gastrointestinal-nematodes-in-southern-africa
#29
JOURNAL ARTICLE
E T Kamba, M Chimonyo
Gastrointestinal nematodes (GIN) exacerbate the impact of droughts on the survival of cattle. The inadequacies of the conventional system make it increasingly important to explore indigenous knowledge (IK) to create drought-tolerant and GIN resilient herds. The objective of the study was to assess the indigenous strategies for controlling GIN during droughts. Face-to-face interviews with experts on IK were conducted to give insight into the importance, methods and ranking of GIN control. The experts identified 86 cattle that were used to test their assertions...
March 12, 2024: Tropical Animal Health and Production
https://read.qxmd.com/read/38471572/type-1-diabetes-lessons-from-a-decade-of-preclinical-studies-on-phytotherapy
#30
REVIEW
Ahmad Ghorbani, Leila Mobasheri, Mostafa Moshirian, Mohaddeseh Sadat Alavi, Omid Fakharzadeh Moghaddam, Niloofar Nikpasand, Elham Einafshar, Mahdyar Esmaeilizadeh
BACKGROUND: In recent decades, numerous herbal products have been shown to have antihyperglycemic and beta cell-regenerative effects in animal studies. However, there is no clinical evidence that those products completely cure patients with type-1 diabetes (T1D). Therefore, it seems that most of the phytochemicals do not have a significant impact on human beta cells, and the results of experimental studies conducted on them may not be generalizable to the clinic. PURPOSE: The present work aims to review extensively the methods and results of preclinical studies on phytotherapy of T1D published in the last 10 years...
March 10, 2024: Fitoterapia
https://read.qxmd.com/read/38462779/effect-of-hesperidin-on-blood-pressure-and-lipid-profile-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#31
REVIEW
Hanumanthappa Shylaja, Gollapalle Lakshminarayanashastry Viswanatha, Venkategowda Sunil, Shalam M Hussain, Syeda Ayesha Farhana
The cardioprotective activity of hesperidin has been well demonstrated in several clinical studies. Also, there is a meta-analysis published on this topic in 2019. However, considering the recently published clinical studies, there is a scope for performing a systematic review and meta-analysis of hesperidin to determine its beneficial effect in alleviating alterations in cardiovascular parameters. In this study, the literature search was performed using online databases such as PubMed and Google Scholar till April 2023 involving randomized controlled studies conducted on hesperidin against various cardiovascular disorders including metabolic disorders in healthy/diseased individuals compared to the placebo/control...
March 10, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38461267/ethnoveterinary-medicinal-plants-and-their-utilization-by-indigenous-and-local-communities-of-dugda-district-central-rift-valley-ethiopia
#32
JOURNAL ARTICLE
Bula Kere Oda, Ermias Lulekal, Bikila Warkineh, Zemede Asfaw, Asfaw Debella
BACKGROUND: Ethnoveterinary medicinal plants have been used by the people of Dugda District in the primary health care system to treat various livestock ailments for generations, particularly, in underserved rural areas. However, these ethnoveterinary practices and medicinal plants are dwindling without proper documentation, due to undergoing socio-cultural and environmental changes. Hence, this study aimed at inventory and analysis of ethnoveterinary medicinal plants and the associated indigenous and local knowledge used in the treatment of livestock health problems in Dugda District...
March 9, 2024: Journal of Ethnobiology and Ethnomedicine
https://read.qxmd.com/read/38459660/dihydrocapsaicin-suppresses-the-sting-mediated-accumulation-of-ros-and-nlrp3-inflammasome-and-alleviates-apoptosis-after-ischemia-reperfusion-injury-of-perforator-skin-flap
#33
JOURNAL ARTICLE
Yingying Lai, Ningning Yang, Xuankuai Chen, Xianhui Ma, Zhuliu Chen, Chengji Dong, Gaoxiang Yu, Yingying Huang, Donghao Shi, Pin Fang, Kejian Fu, Renhao Jiang, Cong Mao, Jian Ding, Weiyang Gao
Avascular necrosis frequently occurs as a complication following surgery involving the distal perforator flap. Dihydrocapsaicin (DHC) can protect tissue from ischemia-reperfusion (I/R) injury, but its specific role in multizone perforator flaps remains unclear. In this study, the prospective target of DHC in the context of I/R injury was predicted using network pharmacology analysis. Flap viability was determined through survival area analysis, laser Doppler blood flow, angiograms, and histological examination...
March 8, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38450815/insights-into-the-anti-candida-albicans-properties-of-natural-phytochemicals-an-in-vitro-and-in-vivo-investigation
#34
REVIEW
Daifan Yue, Dongming Zheng, Yuxin Bai, Linlan Yang, Jiangyan Yong, Yan Li
Invasive candidiasis, attributed to Candida albicans, has long been a formidable threat to human health. Despite the advent of effective therapeutics in recent decades, the mortality rate in affected patient populations remains discouraging. This is exacerbated by the emergence of multidrug resistance, significantly limiting the utility of conventional antifungals. Consequently, researchers are compelled to continuously explore novel solutions. Natural phytochemicals present a potential adjunct to the existing arsenal of agents...
March 7, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38447978/quercetin-inhibits-necroptosis-in-cardiomyocytes-after-ischemia-reperfusion-via-dna-pkcs-sirt5-orchestrated-mitochondrial-quality-control
#35
JOURNAL ARTICLE
Xing Chang, Qin Zhang, Yu Huang, Jinfeng Liu, Yanli Wang, Xuanke Guan, Qiaomin Wu, Zhiming Liu, Ruxiu Liu
We investigated the mechanism by which quercetin preserves mitochondrial quality control (MQC) in cardiomyocytes subjected to ischemia-reperfusion stress. An enzyme-linked immunosorbent assay was employed in the in vivo experiments to assess myocardial injury markers, measure the transcript levels of SIRT5/DNAPK-cs/MLKL during various time intervals of ischemia-reperfusion, and observe structural changes in cardiomyocytes using transmission electron microscopy. In in vitro investigations, adenovirus transfection was employed to establish a gene-modified model of DNA-PKcs, and primary cardiomyocytes were obtained from a mouse model with modified SIRT5 gene...
March 6, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38446350/therapeutic-potential-of-saffron-in-brain-disorders-from-bench-to-bedside
#36
REVIEW
Erjola Bej, Anna Rita Volpe, Patrizia Cesare, Annamaria Cimini, Michele d'Angelo, Vanessa Castelli
Saffron is a spice derived from the flower of Crocus sativus L., which has been used for centuries as a coloring and flavoring agent, as well as a source of medicinal compounds. Saffron contains various bioactive constituents, such as crocin, crocetin, safranal, picrocrocin, and kaempferol, that have shown potential benefits for human health. Among them, crocin is the most abundant and characteristic constituent of saffron, responsible for its bright red color and antioxidant properties. One of the most promising applications of saffron and its constituents is in the prevention and treatment of neurological disorders, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, and other brain disorders...
March 6, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38444049/curculigoside-a-traditional-chinese-medicine-monomer-ameliorates-oxidative-stress-in-alzheimer-s-disease-mouse-model-via-suppressing-ferroptosis
#37
JOURNAL ARTICLE
Yuhang Gong, Yanan Wang, Yanfeng Li, Fanglin Weng, Tong Chen, Ling He
Alzheimer's disease (AD) is a neurodegenerative disorder where oxidative stress, induced by ferroptosis, has been linked to neuronal damage and cognitive deficits. The objective of this study is to investigate if the potential therapeutic agent, Curculigoside (CUR), could ameliorate AD by inhibiting ferroptosis. The potential therapeutic targets, such as GPX4 and SLC7A11, were identified using weighted gene co-expression network analysis (WGCNA). Concurrently, CUR was also screened against these potential targets using various analytical methods...
March 5, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38442321/adverse-effects-of-natural-products-in-the-oral-mucosa-and-face-a-scoping-review
#38
JOURNAL ARTICLE
Débora E Silva Campos, Isis de Araújo Ferreira Muniz, Heloísa Nunes Brandão, Rosemary Sadami Arai Shinkai, Thiago Gomes da Trindade, Dúcia Caldas Cosme-Trindade
Objective: This scoping review aimed to map the adverse reactions in the oral mucosa and face caused by the use of natural products. Methodology: This review was performed according to the Joanna Briggs Institute Manual for Evidence Synthesis and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines, with a protocol registered in the Open Science Framework (DOI 10.17605/OSF.IO/R57D8). The search was carried out systematically using PubMed, Scopus, Web of Science, Embase, LILACS, and LIVIVO databases, as well as gray literature through Google Scholar and OpenGrey...
March 6, 2024: J Integr Complement Med
https://read.qxmd.com/read/38434844/investigating-the-potential-impact-of-air-pollution-on-alzheimer-s-disease-and-the-utility-of-multidimensional-imaging-for-early-detection
#39
REVIEW
Ankul Singh S, Mohd Nazam Ansari, Gehan M Elossaily, Chitra Vellapandian, Bhupendra Prajapati
Pollution is ubiquitous, and much of it is anthropogenic in nature, which is a severe risk factor not only for respiratory infections or asthma sufferers but also for Alzheimer's disease, which has received a lot of attention recently. This Review aims to investigate the primary environmental risk factors and their profound impact on Alzheimer's disease. It underscores the pivotal role of multidimensional imaging in early disease identification and prevention. Conducting a comprehensive review, we delved into a plethora of literature sources available through esteemed databases, including Science Direct, Google Scholar, Scopus, Cochrane, and PubMed...
February 27, 2024: ACS Omega
https://read.qxmd.com/read/38434823/phytochemical-antioxidant-activity-and-toxicity-of-wild-medicinal-plant-of-melitotus-albus-extracts-in-vitro-and-in-silico-approaches
#40
JOURNAL ARTICLE
Imad Ed-Dahmani, Mohamed El Fadili, Fahd Kandsi, Raffaele Conte, Yassine El Atki, Mohammed Kara, Amine Assouguem, Hanane Touijer, Aziza Lfitat, Ghizlane Nouioura, Meryem Slighoua, Riaz Ullah, Jameel H Al-Tamimi, Mustapha Taleb, Abdelfattah Abdellaoui
Morocco is known for its high plant biodiversity, but many plants are poorly valorized. For this reason, this study aims to valorize the methanolic and aqueous extracts of Melitotus albus leaves by studying their antioxidant activity and toxicity. The extracts' antioxidant activity is assessed using the FRAP, DPPH, CAT, and ABTS methods. The chemical composition was determined using LC-MS analysis and evaluated using in silico studies. The results revealed that the total polyphenol content of the aqueous extract, 259...
February 27, 2024: ACS Omega
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