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https://www.readbyqxmd.com/read/28816233/shikonin-induces-glioma-cell-necroptosis-in-vitro-by-ros-overproduction-and-promoting-rip1-rip3-necrosome-formation
#1
Bin Lu, Xu Gong, Zong-Qi Wang, Ye Ding, Chen Wang, Tian-Fei Luo, Mei-Hua Piao, Fan-Kai Meng, Guang-Fan Chi, Yi-Nan Luo, Peng-Fei Ge
Necroptosis is a type of programmed necrosis regulated by receptor interacting protein kinase 1 (RIP1) and RIP3. Necroptosis is found to be accompanied by an overproduction of reactive oxygen species (ROS), but the role of ROS in regulation of necroptosis remains elusive. In this study, we investigated how shikonin, a necroptosis inducer for cancer cells, regulated the signaling leading to necroptosis in glinoma cells in vitro. Treatment with shikonin (2-10 μmol/L) dose-dependently triggered necrosis and induced overproduction of intracellular ROS in rat C6 and human SHG-44, U87 and U251 glioma cell lines...
August 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28811711/fibroblast-derived-cxcl12-sdf-1%C3%AE-promotes-cxcl6-secretion-and-co-operatively-enhances-metastatic-potential-through-the-pi3k-akt-mtor-pathway-in-colon-cancer
#2
Jia-Chi Ma, Xiao-Wen Sun, He Su, Quan Chen, Tian-Kang Guo, Yuan Li, Xiao-Chang Chen, Jin Guo, Zhen-Qiang Gong, Xiao-Dan Zhao, Jian-Bo Qi
AIM: To investigate the underlying mechanism by which CXCL12 and CXCL6 influences the metastatic potential of colon cancer and internal relation of colon cancer and stromal cells. METHODS: Western blotting was used to detect the expression of CXCL12 and CXCL6 in colon cancer cells and stromal cells. The co-operative effects of CXCL12 and CXCL6 on proliferation and invasion of colon cancer cells and human umbilical vein endothelial cells (HUVECs) were determined by enzyme-linked immunosorbent assay, and proliferation and invasion assays...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28810343/-textual-criticism-and-discrimination-on-the-naming-of-five-abstention-soup-of-medical-professional-from-the-han-tomb-of-the-marquis-of-haihun
#3
Y R Wang, Y Yuan, C Q Xu, L J Cao, Y L Wang, L Q Huang
A lacquer vessel with the inscription of Yi gong wu jin tang (Five-abstention Soup of Medical Profession) has been unearthed from the Han-tomb of Marquis of Haihun, in which"Five abstentions"is related to the incantations and abstention therapies prevalent in the Qin and Han Dynasties. The"Five-abstention Law"is the five rituals and methods during the process of practicing incantations and abstentions therapies including"keeping one's thinking (cun si)","holding the breath(bi qi)","twirling eyes (nian mu)","stepping after Yu's sample (yu bu)"and"incanting and blessing (zhou zhu)"...
May 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28804718/cd36-gene-polymorphisms-are-associated-with-intracerebral-hemorrhage-susceptibility-in-a-han-chinese-population
#4
Qiu-Wen Gong, Mao-Fan Liao, Liang Liu, Xiao-Yi Xiong, Qin Zhang, Qi Zhong, Kai Zhou, Yuan-Rui Yang, Zhao-You Meng, Chang-Xiong Gong, Rui Xu, Qing-Wu Yang
The CD36 gene encodes a membrane glycoprotein (type B scavenger receptor, SR-B2) that plays a crucial role in lipid sensing, innate immunity, atherogenesis, and glycolipid metabolism. In this study, we aimed to investigate the association between CD36 gene polymorphisms and intracerebral hemorrhage (ICH) in a Han Chinese population. We performed genotype and allele analyses for eleven single nucleotide polymorphisms (SNPs) of CD36 in a case-controlled study involving 292 ICH patients and 298 control participants...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28803443/solasodine-inhibits-human-colorectal-cancer-cells-via-suppression-of-akt-gsk-3%C3%AE-%C3%AE-catenin-pathway
#5
Yu-Wen Zhuang, Cun-En Wu, Jin-Yong Zhou, Xu Chen, Jian Wu, Shan Jiang, Hai-Yan Peng, Xi Zou, Jia-Yun Liu, Da-Peng Wu, Tao Gong, Ming-Hao Qi, Tian Xue, Shen-Lin Liu, Hui Cai
Solasodine is a main active component isolated from Solanum incanum L, who performs a wide range of functions containing anti-oxidant, anti-infection and neurogenesis promotion. In this study, we explored the influence of solasodine on three types of human colorectal cancer (CRC) cell lines. The consequences displayed that solasodine apparently prohibited CRC cell proliferation dose- and time-dependently and impeded CRC cell motility by downregulating Matrix metalloprotease (MMPs). Besides, solasodine was investigated to fuel caspase-cascade reaction and increase the ratio between Bax and Bcl-2 so as to induce CRC cell apoptosis...
August 13, 2017: Cancer Science
https://www.readbyqxmd.com/read/28791379/felodipine-inhibits-ox-ldl-induced-reactive-oxygen-species-production-and-inflammation-in-human-umbilical-vein-endothelial-cells
#6
Jie Qi, Jian-Bao Zheng, Wen-Ting Ai, Xiao-Wei Yao, Lei Liang, Gong Cheng, Xi-Ling Shou, Chao-Feng Sun
Oxidative stress and inflammation are involved in the pathogenesis of atherosclerosis. Calcium channel blockers (CCBs) inhibit the development of atherosclerosis, although the underlying molecular basis has not been completely elucidated. The present study was designed to investigate the effects of felodipine, a CCB, on inflammation and oxidative stress in human umbilical vein endothelial cells (HUVECs) and to examine the underlying mechanisms of action. Oxidized low‑density lipoprotein (ox‑LDL) was used to induce an inflammatory response in HUVECs...
August 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28791041/conserved-function-of-acyl-acyl-carrier-protein-desaturase-5-on-seed-oil-and-oleic-acid-biosynthesis-between-arabidopsis-thaliana-and-brassica-napus
#7
Changyu Jin, Dong Li, Chenhao Gao, Kaige Liu, Shuanghui Qi, Shaowei Duan, Zixiong Li, Jingyun Gong, Jianjun Wang, Jiangbo Hai, Mingxun Chen
Previous studies have shown that several ACYL-ACYL CARRIER PROTEIN DESATURASE (AtAAD) members in Arabidopsis thaliana are responsible for oleic acid (C18:1) biosynthesis. Limited research has been conducted on another member, AtAAD5, and its paralog BnAAD5 in the closely related and commercially important plant, Brassica napus. Here, we found that AtAAD5 was predominantly and exclusively expressed in developing embryos at the whole seed developmental stages. The aad5 mutation caused a significant decrease in the amounts of oil and C18:1, and a considerable increase in the content of stearic acid (C18:0) in mature seeds, suggesting that AtAAD5 functioned as an important facilitator of seed oil biosynthesis...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28781951/ifitm1-suppresses-expression-of-human-endogenous-retroviruses-in-human-embryonic-stem-cells
#8
Yudong Fu, Zhongcheng Zhou, Hua Wang, Peng Gong, Renpeng Guo, Jinmiao Wang, Xinyi Lu, Feng Qi, Lin Liu
Interferon-induced transmembrane protein 1 (IFITM1), a member of the IFITM protein family, is a component of a multimeric complex involved in the transduction of antiproliferation and cell adhesion signals. IFITM1 is thought to play a role in antiproliferation and immune surveillance, and has been shown to restrict infection by numerous viruses. It is highly expressed in human embryonic stem cells (hESCs) but its role in hESCs remains to be elucidated. In this study, knockout of IFITM1 mediated by CRISPR/Cas9 in hESCs did not affect self-renewal, pluripotency, telomerase activity or telomeres...
August 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28776935/shorter-telomere-length-increases-age-related-tumor-risks-in-von-hippel-lindau-disease-patients
#9
Jiang-Yi Wang, Shuang-He Peng, Xiang-Hui Ning, Teng Li, Sheng-Jie Liu, Jia-Yuan Liu, Bao-An Hong, Nie-Nie Qi, Xiang Peng, Bo-Wen Zhou, Jiu-Feng Zhang, Lin Cai, Kan Gong
Von Hippel-Lindau (VHL) disease is a rare autosomal dominant cancer syndrome caused by alterations of VHL gene. Patients are predisposed to develop pheochromocytomas and solid or cystic tumors of the central nervous system, kidney, pancreas, and retina. Remarkable phenotypic heterogeneity exits in organ involvement and tumor onset age between and within VHL families. However, no reliable markers have been found to predict the age-related tumor risks in VHL patients. A large Chinese cohort composed of 300 VHL patients and 92 healthy family controls was enrolled in our study...
August 4, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28728551/reduced-glutathione-and-glutathione-disulfide-in-the-blood-of-glucose-6-phosphate-dehydrogenase-deficient-newborns
#10
Zhen-Hua Gong, Guo-Li Tian, Qi-Wei Huang, Yan-Min Wang, Hong-Ping Xu
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is commonly detected during mass screening for neonatal disease. We developed a method to measure reduced glutathione (GSH) and glutathione disulfide (GSSG) using tandem mass spectrometry (MS/MS) for detecting G6PD deficiency. METHODS: The concentration of GSH and the GSH/GSSG ratio in newborn dry-blood-spot (DBS) screening and in blood plus sodium citrate for test confirmation were examined by MS/MS using labeled glycine as an internal standard...
July 20, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28724654/mfsd2a-major-facilitator-superfamily-domain-containing-2a-attenuates-intracerebral-hemorrhage-induced-blood-brain-barrier-disruption-by-inhibiting-vesicular-transcytosis
#11
Yuan-Rui Yang, Xiao-Yi Xiong, Juan Liu, Li-Rong Wu, Qi Zhong, Kai Zhou, Zhao-You Meng, Liang Liu, Fa-Xiang Wang, Qiu-Wen Gong, Mao-Fan Liao, Chun-Mei Duan, Jie Li, Mei-Hua Yang, Qin Zhang, Chang-Xiong Gong, Qing-Wu Yang
BACKGROUND: Blood-brain barrier (BBB) disruption aggravates brain injury induced by intracerebral hemorrhage (ICH); however, the mechanisms of BBB damage caused by ICH remain elusive. Mfsd2a (major facilitator superfamily domain containing 2a) has been known to play an essential role in BBB formation and function. In this study, we investigated the role and underlying mechanisms of Mfsd2a in BBB permeability regulation after ICH. METHODS AND RESULTS: Using ICH models, we found that Mfsd2a protein expression in perihematomal brain tissues was significantly decreased after ICH...
July 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28720118/inhibiting-function-of-human-fetal-dermal-mesenchymal-stem-cells-on-bioactivities-of-keloid-fibroblasts
#12
Ya Jiao, Xiao Wang, Jixun Zhang, Yongjun Qi, Hongmin Gong, Duyin Jiang
BACKGROUND: Keloid is one kind of benign skin disease caused by hyperplasia of fibroblasts and collagen fibrils. It is refractory due to the lack of an effective treatment at present, which puts pressure on seeking a new therapeutic regimen. Mesenchymal stem cells (MSCs) from fetal skin are considered to play a crucial role in scarless healing. Nevertheless, the efficacy of them in keloid disorders remains poorly understood. METHODS: Keloid fibroblasts (KFs), human adult dermal fibroblasts (ADFs), and human fetal dermal mesenchymal stem cells (FDMSCs) were isolated to single cells and cultured in Dulbecco's modified Eagle's medium (DMEM)...
July 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28713985/microarray-expression-profiles-of-long-non-coding-rnas-in-germinal-center-like-diffuse-large-b-cell-lymphoma
#13
Hong-Yu Gao, Bin Wu, Wei Yan, Zi-Mu Gong, Qi Sun, Hui-Han Wang, Wei Yang
Long non-coding RNAs (lncRNAs) are continuously transcribed and are involved in various cellular activities. However, their contributions to the occurrence and development of germinal center B-cell (GCB)-like diffuse large B-cell lymphoma (DLBCL) remain largely unknown. We applied microarray technology to profile the expression of lncRNAs in two different GCB-DLBCL cell lines (OCI-ly1 and OCI-ly19) and normal B lymphocytes. We demonstrated that 21,539 lncRNAs were expressed in all of the samples analyzed...
September 2017: Oncology Reports
https://www.readbyqxmd.com/read/28713408/transcriptome-analyses-shed-new-insights-into-primary-metabolism-and-regulation-of-blumeria-graminis-f-sp-tritici-during-conidiation
#14
Fan-Song Zeng, Fabrizio Menardo, Min-Feng Xue, Xue-Jiang Zhang, Shuang-Jun Gong, Li-Jun Yang, Wen-Qi Shi, Da-Zhao Yu
Conidia of the obligate biotrophic fungal pathogen Blumeria graminis f. sp. tritici (Bgt) play a vital role in its survival and rapid dispersal. However, little is known about the genetic basis for its asexual reproduction. To uncover the primary metabolic and regulatory events during conidiation, we sequenced the transcriptome of Bgt epiphytic structures at 3 (vegetative hyphae growth), 4 (foot cells initiation), and 5 (conidiophore erection) days post-inoculation (dpi). RNA-seq analyses identified 556 and 404 (combined 685) differentially expressed genes (DEGs) at 4 and 5 dpi compared with their expression levels at 3 dpi, respectively...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28704753/resveratrol-improves-prostate-fibrosis-during-progression-of-urinary-dysfunction-in-chronic-prostatitis
#15
Yi He, Hui-Zhi Zeng, Yang Yu, Jia-Shu Zhang, Xingping Duan, Xiao-Na Zeng, Feng-Tao Gong, Qi Liu, Bo Yang
AIM: We investigated whether prostate fibrosis was associated with urinary dysfunction in chronic prostatitis (CP) and whether resveratrol improved urinary dysfunction and the underlying molecular mechanism. METHODS: Rat model of CP was established via subcutaneous injections of DPT vaccine and subsequently treated with resveratrol. Bladder pressure and volume tests investigated the effect of resveratrol on urinary dysfunction in CP rats. Western blotting and immunohistochemical staining examined the expression level of C-kit/SCF and TGF-β/Wnt/β-catenin...
July 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28699207/supplemental-effect-of-different-levels-of-taurine-in-modena-on-boar-semen-quality-during-liquid-preservation-at-17%C3%A2-c
#16
Hao Li, Xiao-Gang Zhang, Qian Fang, Qi Liu, Ren-Rang Du, Gong-She Yang, Li-Qiang Wang, Jian-Hong Hu
Peroxidation damage induces sublethal injury to boar sperm during the storage process. Taurine has already been demonstrated to protect cells effectively from oxidant-induced injury. This study was aimed to evaluate the effect of different concentrations of taurine (0.5, 1, 5 and 10 mmol/L) in Modena diluent on boar sperm quality during liquid storage at 17°C. Ejaculates from sexually mature Duroc pigs were collected, pooled and preserved in the Modena containing different concentrations of taurine. Sperm motility, plasma membrane integrity, acrosome integrity, total antioxidative capacity (T-AOC) activity and malondialdehyde content (MDA) were examined every 24 h...
July 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28696753/evolution-of-the-reactor-antineutrino-flux-and-spectrum-at-daya-bay
#17
F P An, A B Balantekin, H R Band, M Bishai, S Blyth, D Cao, G F Cao, J Cao, Y L Chan, J F Chang, Y Chang, H S Chen, Q Y Chen, S M Chen, Y X Chen, Y Chen, J Cheng, Z K Cheng, J J Cherwinka, M C Chu, A Chukanov, J P Cummings, Y Y Ding, M V Diwan, M Dolgareva, J Dove, D A Dwyer, W R Edwards, R Gill, M Gonchar, G H Gong, H Gong, M Grassi, W Q Gu, L Guo, X H Guo, Y H Guo, Z Guo, R W Hackenburg, S Hans, M He, K M Heeger, Y K Heng, A Higuera, Y B Hsiung, B Z Hu, T Hu, E C Huang, H X Huang, X T Huang, Y B Huang, P Huber, W Huo, G Hussain, D E Jaffe, K L Jen, X P Ji, X L Ji, J B Jiao, R A Johnson, D Jones, L Kang, S H Kettell, A Khan, S Kohn, M Kramer, K K Kwan, M W Kwok, T J Langford, K Lau, L Lebanowski, J Lee, J H C Lee, R T Lei, R Leitner, J K C Leung, C Li, D J Li, F Li, G S Li, Q J Li, S Li, S C Li, W D Li, X N Li, X Q Li, Y F Li, Z B Li, H Liang, C J Lin, G L Lin, S Lin, S K Lin, Y-C Lin, J J Ling, J M Link, L Littenberg, B R Littlejohn, J L Liu, J C Liu, C W Loh, C Lu, H Q Lu, J S Lu, K B Luk, X Y Ma, X B Ma, Y Q Ma, Y Malyshkin, D A Martinez Caicedo, K T McDonald, R D McKeown, I Mitchell, Y Nakajima, J Napolitano, D Naumov, E Naumova, H Y Ngai, J P Ochoa-Ricoux, A Olshevskiy, H-R Pan, J Park, S Patton, V Pec, J C Peng, L Pinsky, C S J Pun, F Z Qi, M Qi, X Qian, R M Qiu, N Raper, J Ren, R Rosero, B Roskovec, X C Ruan, H Steiner, P Stoler, J L Sun, W Tang, D Taychenachev, K Treskov, K V Tsang, C E Tull, N Viaux, B Viren, V Vorobel, C H Wang, M Wang, N Y Wang, R G Wang, W Wang, X Wang, Y F Wang, Z Wang, Z Wang, Z M Wang, H Y Wei, L J Wen, K Whisnant, C G White, L Whitehead, T Wise, H L H Wong, S C F Wong, E Worcester, C-H Wu, Q Wu, W J Wu, D M Xia, J K Xia, Z Z Xing, J L Xu, Y Xu, T Xue, C G Yang, H Yang, L Yang, M S Yang, M T Yang, Y Z Yang, M Ye, Z Ye, M Yeh, B L Young, Z Y Yu, S Zeng, L Zhan, C Zhang, C C Zhang, H H Zhang, J W Zhang, Q M Zhang, R Zhang, X T Zhang, Y M Zhang, Y X Zhang, Y M Zhang, Z J Zhang, Z Y Zhang, Z P Zhang, J Zhao, L Zhou, H L Zhuang, J H Zou
The Daya Bay experiment has observed correlations between reactor core fuel evolution and changes in the reactor antineutrino flux and energy spectrum. Four antineutrino detectors in two experimental halls were used to identify 2.2 million inverse beta decays (IBDs) over 1230 days spanning multiple fuel cycles for each of six 2.9 GW_{th} reactor cores at the Daya Bay and Ling Ao nuclear power plants. Using detector data spanning effective ^{239}Pu fission fractions F_{239} from 0.25 to 0.35, Daya Bay measures an average IBD yield σ[over ¯]_{f} of (5...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28693818/arterial-wall-remodeling-under-sustained-axial-twisting-in-rats
#18
Guo-Liang Wang, Li-Yi Wang, Shao-Xiong Yang, Ping Zhang, Xiao-Hu Chen, Qing-Ping Yao, Xiao-Bo Gong, Ying-Xin Qi, Zong-Lai Jiang, Hai-Chao Han
Blood vessels often experience torsion along their axes and it is essential to understand their biological responses and wall remodeling under torsion. To this end, a rat model was developed to investigate the arterial wall remodeling under sustained axial twisting in vivo. Rat carotid arteries were twisted at 180° along the longitudinal axis through a surgical procedure and maintained for different durations up to 4weeks. The wall remodeling in these twisted arteries was examined using histology, immunohistochemistry and fluorescent microscopy...
June 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28691150/quantitative-analysis-of-total-starch-content-in-wheat-flour-by-reaction-headspace-gas-chromatography
#19
Wei-Qi Xie, Yi-Xian Gong, Kong-Xian Yu
This paper proposed a new reaction headspace gas chromatographic (HS-GC) method for efficiently quantifying the total starch content in wheat flours. A certain weight of wheat flour was oxidized by potassium dichromate in an acidic condition in a sealed headspace vial. The results show that the starch in wheat flour can be completely transferred to carbon dioxide at the given conditions (at 100 °C for 40 min) and the total starch content in wheat flour sample can be indirectly quantified by detecting the CO2 formed from the oxidation reaction...
July 10, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28688762/thioredoxin-attenuates-oxidized-low-density-lipoprotein-induced-oxidative-stress-in-human-umbilical-vein-endothelial-cells-by-reducing-nadph-oxidase-activity
#20
Beidong Chen, Li Meng, Tao Shen, Huan Gong, Ruomei Qi, Yanyang Zhao, Jie Sun, Li Bao, Gexin Zhao
Oxidative stress is recognized as one of the most important contributing factors to the development of atherosclerosis. Oxidized low-density lipoprotein (ox-LDL) can induce vascular reactive oxygen species (ROS) production, trigger endothelial dysfunction and initiate the progression of atherosclerosis. Previous studies have demonstrated that thioredoxin-1 (Trx) is one of the key regulators of intracellular redox, which is pivotal in atherogenesis. However, the regulation mechanism is still unclear. In this study, we investigated the effects of Trx1 on NADPH oxidase in human umbilical vein endothelial cells (HUVECs), whose ROS level is mainly produced by NADPH oxidase, especially Nox4 isoform...
September 2, 2017: Biochemical and Biophysical Research Communications
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