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https://www.readbyqxmd.com/read/29164850/exploring-highly-reversible-1-5-electron-reactions-v3-v4-v5-in-na3vcr-po4-3-cathode-for-sodium-ion-batteries
#1
Rui Liu, Guiliang Xu, Qi Li, Shiyao Zheng, Guorui Zheng, Zhengliang Gong, Yixiao Li, Elizaveta Kruskop, Riqiang Fu, Zonghai Chen, Khalil Amine, Yong Yang
Development of highly reversible multi-electron reaction per redox center in NASICON-structured cathode materials is desired to improve the energy density of Sodium-ion batteries. Here, we investigated more than one electron storage of Na in Na3VCr(PO4)3. Combining a series of advanced characterization techniques such as ex situ 51V solid-state nuclear magnetic resonance, X-ray absorption near edge structure and in situ X-ray diffraction, we reveal that, V3+/V4+ and V4+/V5+ redox couples in the materials can be accessed, leading to 1...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29156537/ursolic-acid-ameliorates-oxidative-stress-inflammation-and-fibrosis-in-diabetic-cardiomyopathy-rats
#2
Xu-Tao Wang, Yan Gong, Bin Zhou, Jun-Jie Yang, Yin Cheng, Jin-Guo Zhao, Min-You Qi
Diabetic cardiomyopathy is a major and severe cardiovascular complication of diabetes mellitus. Ursolic acid, a pentacyclic triterpene compound widespread in fruits and plants, performs a variety of pharmacological activities including lowering blood glucose, anti-oxidation, anti-inflammation and anti-fibrosis. Our present study aimed to investigate the cardioprotective effects of ursolic acid on diabetic cardiomyopathy rats and uncover its underlying mechanism. Diabetes mellitus was induced by a single injection of STZ-only (40 mg/ kg, i...
November 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29151181/screening-hcv-genotype-specific-epitope-peptides-based-on-conserved-sequence-analysis-and-b-cell-epitope-prediction-in-hcv-e2-region
#3
Rui Hua, Xiaoyu Jiang, Lingxia Qi, Shanshan Guan, Ziyu Kuai, Yongbo Qiao, Yan Xu, Xin Gong, Yuhua Shi, Wei Kong, Junqi Niu, Hao Zhang, Yaming Shan
The high mutation rate of the hepatitis C virus (HCV) genome increases the genotype diversity and renders the detection of the virus more difficult. Therefore, prediction and assessment of highly conserved and strongly antigenic epitope polypeptide sequences have become a focus of current research. The E2 region is the target binding region of neutralizing antibodies. HCV genomics, especially the high mutation rate of E2 region sequence, makes its genotyping more and more diverse, and the detection of HCV and genotype is becoming more and more strict...
November 18, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29150438/a-pip2-derived-amplification-loop-fuels-the-sustained-initiation-of-b-cell-activation
#4
Chenguang Xu, Hengyi Xie, Xingdong Guo, Haipeng Gong, Lei Liu, Hai Qi, Chenqi Xu, Wanli Liu
Lymphocytes have evolved sophisticated signaling amplification mechanisms to efficiently activate downstream signaling after detection of rare ligands in their microenvironment. B cell receptor microscopic clusters (BCR microclusters) are assembled on the plasma membrane and recruit signaling molecules for the initiation of lymphocyte signaling after antigen binding. We identified a signaling amplification loop derived from phosphatidylinositol 4,5-biphosphate (PIP2) for the sustained B cell activation. Upon antigen recognition, PIP2 was depleted by phospholipase C-γ2 (PLC-γ2) within the BCR microclusters and was regenerated by phosphatidic acid-dependent type I phosphatidylinositol 4-phosphate 5-kinase outside the BCR microclusters...
November 17, 2017: Science Immunology
https://www.readbyqxmd.com/read/29145276/endovascular-stenting-of-spontaneous-isolated-dissection-of-the-superior-mesenteric-artery-a-case-report-and-literature-review
#5
Dong-Na Gao, Qing-Hui Qi, Ping Gong
RATIONALE: Spontaneous isolated dissection of the superior mesenteric artery (SID-SMA) is a rare arterial disease that is difficult to differentiate from other diseases because of lack of specific clinical manifestation and for which there is no available optimal management strategy. PATIENT CONCERNS: A 58-year-old male patient visited our emergency room with sudden onset of moderate-severe epigastric abdominal pain of uncertain cause. DIAGNOSES: Computed tomography scanning showed a characteristic "double lumen sign" of the superior mesenteric artery, and further computed tomography angiography findings revealed a dissected segment of the superior mesenteric artery...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143697/stroke-and-food-groups-an-overview-of-systematic-reviews-and-meta-analyses
#6
Cuiyu Deng, Qi Lu, Bingyan Gong, Liya Li, Lianxia Chang, Li Fu, Yue Zhao
OBJECTIVE: Numerous systematic reviews of prospective studies on the association of stroke risk with the consumption of various food groups have been published. A review of the evidence across the existing systematic reviews and meta-analyses of prospective studies was conducted to provide an overview of the range and validity of the reported associations of food groups with stroke risk. DESIGN: The PubMed, EMBASE and Cochrane Library databases were searched for articles published up to September 2015 to identify systematic reviews of prospective studies...
November 16, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29132039/the-cxcl12-cxcr4-signaling-promotes-oocyte-maturation-by-regulating-cumulus-expansion-in-sheep
#7
Rui-Na Zhang, Bo Pang, Shang-Rong Xu, Peng-Cheng Wan, Song-Chang Guo, Han-Zhong Ji, Gong-Xue Jia, Lin-Yong Hu, Xin-Quan Zhao, Qi-En Yang
Gonadotropins and growth factors synergistically regulate folliculogenesis and oocyte development. C-X-C motif chemokine 12 (CXCL12) and its receptor CXCR4 are expressed in ovaries of sheep, cattle and other species, however, roles of this multifunctional signal axis in oocyte maturation are not defined. Using sheep as a model, we examined the expression patterns and functions of the CXCL12-CXCR4 axis during oocyte maturation. CXCL12 and CXCR4 mRNA and protein were present in oocytes and granulosa cells. Relative abundance of CXCR4 transcript was controlled by epidermal growth factor (EGF)...
November 4, 2017: Theriogenology
https://www.readbyqxmd.com/read/29126221/identification-and-characterization-of-mcr-mediated-colistin-resistance-in-extraintestinal-escherichia-coli-from-poultry-and-livestock-in-china
#8
Afrah Kamal Yassin, Jilei Zhang, Jiawei Wang, Li Chen, Patrick Kelly, Patrick Butaye, Guangwu Lu, Jiansen Gong, Min Li, Lanjing Wei, Yaoyao Wang, Kezong Qi, Xiangan Han, Stuart Price, Terri Hathcock, Chengming Wang
Antimicrobial resistance to colistin has emerged worldwide threatening the efficacy of one of the last-resort antimicrobials used for the treatment of multidrug-resistant Enterobacteriaceae infection in humans. In this study, we investigated the presence of colistin resistance genes (mcr-1, mcr-2, mcr-3) in Escherichia coli strains isolated from poultry and livestock collected between 2004 and 2012 in China. Furthermore, we studied the maintenance and transfer of the mcr-1 gene in E. coli after serial passages...
November 8, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29120854/the-protective-effects-of-bacillus-licheniformis-preparation-on-gastrointestinal-disorders-and-inflammation-induced-by-radiotherapy-in-pediatric-with-central-nervous-system-tumor
#9
Shu-Xu Du, Yong-Rui Jia, Si-Qi Ren, Xiao-Jun Gong, Hong Tang, Wu Wan-Shui, Sun Li-Ming
PURPOSE: we studied the effect of Bacillus licheniformis preparation (ZCS) on CNST (central nervous system tumor) patients undergoing the gastrointestinal symptoms and inflammation induced by radiotherapy. MATERIALS AND METHODS: 160 CNST patients with craniospinal irradiation (CSI) treatment were divided into experiment and control group. The experiment group patients took one capsule per time of ZCS and three times a day until the end of radiotherapy, starting one day before radiotherapy...
November 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29118379/a-new-antagonist-for-ccr4-attenuates-allergic-lung-inflammation-in-a-mouse-model-of-asthma
#10
Yang Zhang, Yinfang Wu, Hui Qi, Hongwei Gong, Yan Zhang, Enquan Xu, Song Li, Dalong Ma, Junhai Xiao, Ying Wang, Wen Li, Huahao Shen
CCR4 is highly expressed on Th2 cells. CCR4 ligands include CCL22 and CCL17. Chemokine-like factor 1 can also mediate chemotaxis via CCR4. We designed and synthetized novel CCR4 antagonists, which were piperazinyl pyridine derivatives, for disrupting the interaction between three ligands and CCR4. We also determined whether these novel CCR4 antagonists could alleviate allergic asthma in a mouse. For identifying the potent compounds in vitro, we used chemotaxis inhibition and competition binding assays induced by CCL22, CCL17 and one of CKLF1's C-terminal peptides, C27...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116543/remission-assessment-of-rheumatoid-arthritis-in-daily-practice-in-china-a-cross-sectional-observational-study
#11
Huaqun Zhu, Ru Li, Zhanyun Da, Liqi Bi, Xiangpei Li, Yang Li, Chongyang Liu, Fengxiao Zhang, Zhijun Li, Xiangyuan Liu, Zhiyi Zhang, Lingyun Sun, Youlian Wang, Wei Zhang, Quan Jiang, Jinwei Chen, Qingping Chen, Zhenbin Li, Lijun Wu, Wencheng Qi, Jianhua Xu, Xiangjun Cui, Xiaofei Wang, Long Li, Xiaomei Leng, Guochun Wang, Dongbao Zhao, Lindi Jiang, Dongyi He, Xiaomin Liu, Ling Li, Yongfei Fang, Cibo Huang, Huaxiang Wu, Shaoxian Hu, Qin Li, Hui Song, Weiguo Xiao, Lu Gong, Liaojia Zhang, Xiaofeng Li, Zhanguo Li, Yin Su
The objective of this study is to evaluate the remission rate and describe the current use of medication in a large cohort of rheumatoid arthritis (RA) patients under routine clinical care in China. RA patients were recruited from 40 large teaching hospitals nationwide in China. Data regarding RA disease activity, medication treatment, and adverse events were recorded using a standardized clinical data questionnaire. RA remission was evaluated by the 28 Joint Disease Activity Score DAS28-ESR Clinical Disease Activity Index (CDAI), Simplified Disease Activity Index (SDAI), and American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria...
November 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29115491/resveratrol-improves-prostate-fibrosis-during-progression-of-urinary-dysfunction-in-chronic-prostatitis-by-mast-cell-suppression
#12
Huizhi Zeng, Yi He, Yang Yu, Jiashu Zhang, Xiaona Zeng, Fengtao Gong, Qi Liu, Bo Yang
Voiding dysfunction is the primary clinical manifestation of chronic prostatitis (CP), which is a common urological disease. The present study investigated whether prostate fibrosis was associated with urinary dysfunction in CP and if resveratrol improved urinary dysfunction, and the underlying molecular mechanism. A rat model of CP was established via subcutaneous injections of the pertussis‑diphtheria‑tetanus vaccine, which was followed by treatment with resveratrol. Bladder pressure and volume tests were performed to investigate the effect of resveratrol on urinary dysfunction in CP rats...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113305/vinpocetine-alleviate-cerebral-ischemia-reperfusion-injury-by-down-regulating-tlr4-myd88-nf-%C3%AE%C2%BAb-signaling
#13
Li-Rong Wu, Liang Liu, Xiao-Yi Xiong, Qin Zhang, Fa-Xiang Wang, Chang-Xiong Gong, Qi Zhong, Yuan-Rui Yang, Zhao-You Meng, Qing-Wu Yang
Inflammatory responses play crucial roles in cerebral ischemia/reperfusion injury. Toll-like receptor 4 (TLR4) is an important mediator of the neuroinflammatory response to cerebral ischemia/reperfusion injury. Vinpocetine is a derivative of the alkaloid vincamine and exerts an anti-inflammatory effect by inhibiting NF-κB activation. However, the effects of vinpocetine on pathways upstream of NF-κB signaling, such as TLR4, have not been fully elucidated. Here, we used mouse middle cerebral artery occlusion (MCAO) and cell-based oxygen-glucose deprivation (OGD) models to evaluate the therapeutic effects and mechanisms of vinpocetine treatment...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108914/detection-and-analysis-of-apoptosis-and-autophagy-related-mirnas-of-mouse-vascular-endothelial-cells-in-chronic-intermittent-hypoxia-model
#14
Kai-Xiong Liu, Gong-Ping Chen, Ping-Li Lin, Jian-Chai Huang, Xin Lin, Jia-Chao Qi, Qi-Chang Lin
Endothelial dysfunction is the main pathogenic mechanism of cardiovascular complications induced by obstructive sleep apnea/hyponea syndrome (OSAHS). Chronic intermittent hypoxia (CIH) is the primary factor of OSAHS-associated endothelial dysfunction. The hypoxia inducible factor (HIF) pathway regulates the expression of downstream target genes and mediates cell apoptosis caused by CIH-induced endothelial injury. miRNAs play extensive and important negative regulatory roles in this process at the post-transcriptional level...
November 3, 2017: Life Sciences
https://www.readbyqxmd.com/read/29106389/cul4b-promotes-gastric-cancer-invasion-and-metastasis-involvement-of-upregulation-of-her2
#15
M Qi, M Jiao, X Li, J Hu, L Wang, Y Zou, M Zhao, R Zhang, H Liu, J Mi, L Zhang, L Liu, Y Gong, B Han
Cullin 4B (CUL4B) is a scaffold protein overexpressed in several solid malignancies. It is known to silence tumor suppressor through post-transcriptional manner. However, its clinical significance and underlying molecular mechanisms in gastric cancer (GC) remain largely unknown. In this study, we found that CUL4B was significantly overexpressed in GC tissues and its overexpression was correlated with lymph node metastasis and poor prognosis. Through gain- and loss-of-function experiments, we showed that CUL4B promotes GC cell invasion and epithelial-mesenchymal transition (EMT) in vitro, as well as tumor growth and metastasis in vivo...
November 6, 2017: Oncogene
https://www.readbyqxmd.com/read/29101267/identification-and-verification-of-potential-pirnas-from-domesticated-yak-testis
#16
Jishang Gong, Quanwei Zhang, Qi Wang, Youji Ma, Jiaxiang Du, Yong Zhang, Xingxu Zhao
PIWI-interacting RNAs (piRNA) are small non-coding RNA molecules expressed in animal germ cells that interact with PIWI family proteins to form RNA- protein complexes involved in epigenetic and post- transcriptional gene silencing of retrotransposons and other genetic elements in germ line cells, including reproductive stem cell self- sustainment, differentiation, meiosis and spermatogenesis. In the present study, weperformed high- throughput sequencing of piRNAs in testis samples from yaks in different stages of sexual maturity...
November 3, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29100349/alu-hypomethylation-and-mgmt-hypermethylation-in-serum-as-biomarkers-of-glioma
#17
Mingjie Gong, Wei Shi, Jing Qi, Guoping Shao, Zhenghua Shi, Junxiang Wang, Jian Chen, Rongtao Chu
In order to improve prognosis of glioma patients, better tools are required for early diagnosis and treatment. Serum cell-free DNA methylation levels of Alu, MGMT, P16, RASSF1A from 124 glioma patients and 58 healthy controls were detected by the bisulfite sequencing. The median methylation level of Alu was 46.15% (IQR, 36.57%-54.00%) and 60.85% (IQR, 57.23%-65.68%) in glioma patients and healthy controls respectively. The median methylation level of MGMT in glioma samples was 64.65% (IQR, 54.87%-74.37%) compared to 38...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100277/thrombospondin-1-promotes-cell-migration-invasion-and-lung-metastasis-of-osteosarcoma-through-fak-dependent-pathway
#18
Chuanzhen Hu, Junxiang Wen, Liangzhi Gong, Xu Chen, Jun Wang, Fangqiong Hu, Qi Zhou, Jing Liang, Li Wei, Yuhui Shen, Weibin Zhang
Microenvironment at the metastatic locus usually differs greatly from that present in the site of primary tumor formation and it has a significant impact on the fate of the extravasated cancer cells. We compared gene expression signatures of primary tumors and lung metastatic tumors, and identified Thrombospondin-1 (TSP1) as highly up-regulated in the lung metastatic tumors. Immunohistochemical staining further indicated that TSP1 protein expression was higher in lung metastatic tumors compared to primary tumors in both osteosarcoma xenograft model and human clinical samples...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098409/variations-in-monascus-pigment-characteristics-and-biosynthetic-gene-expression-using-resting-cell-culture-systems-combined-with-extractive-fermentation
#19
Gong Chen, Qi Bei, Tao Huang, Zhenqiang Wu
Monascus pigments are promising sources of natural food colorants, and their productivity can be improved by a novel extractive fermentation technology. In this study, we investigated the variations in pigment characteristics and biosynthetic gene expression levels in resting cell culture systems combined with extractive fermentation in Monascus anka GIM 3.592. Although the biomass was low at about 6 g/L DCW, high pigment titer of approximately 130 AU470 was obtained in the resting culture with cells from extractive fermentation, illustrating that it had a good biocatalytic activity for pigment synthesis...
November 2, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29079782/camkii-mediated-beclin-1-phosphorylation-regulates-autophagy-that-promotes-degradation-of-id-and-neuroblastoma-cell-differentiation
#20
Xuan Li, Xiao-Qi Wu, Rong Deng, Dan-Dan Li, Jun Tang, Wen-Dan Chen, Jing-Hong Chen, Jiao Ji, Lin Jiao, Shan Jiang, Fen Yang, Gong-Kan Feng, Ravichandran Senthilkumar, Fei Yue, Hai-Liang Zhang, Rui-Yan Wu, Yan Yu, Xue-Lian Xu, Jia Mai, Zhi-Ling Li, Xiao-Dan Peng, Yun Huang, Xiang Huang, Ning-Fang Ma, Qian Tao, Yi-Xin Zeng, Xiao-Feng Zhu
Autophagy is a degradative pathway that delivers cellular components to the lysosome for degradation. The role of autophagy in cell differentiation is poorly understood. Here we show that CaMKII can directly phosphorylate Beclin 1 at Ser90 to promote K63-linked ubiquitination of Beclin 1 and activation of autophagy. Meanwhile, CaMKII can also promote K63-linked ubiquitination of inhibitor of differentiation 1/2 (Id-1/2) by catalyzing phosphorylation of Id proteins and recruiting TRAF-6. Ubiquitinated Id-1/Id-2 can then bind to p62 and be transported to autolysosomes for degradation...
October 27, 2017: Nature Communications
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