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1,25 hydroxyvitamin D

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https://www.readbyqxmd.com/read/29242845/no-effect-of-vitamin-d-supplementation-on-cardiovascular-risk-factors-in-subjects-with-metabolic-syndrome-a-pilot-randomised-study
#1
Stefania E Makariou, Moses Elisaf, Anna Challa, Nikolaos Tentolouris, Evangelos N Liberopoulos
Introduction: Patients with metabolic syndrome (MetS) may have lower 25-hydroxyvitamin D (25(OH)VitD) serum levels compared with non-MetS individuals. Vitamin D (VitD) deficiency is associated with various cardiovascular disease (CVD) risk factors. Yet, the effect of VitD supplementation on MetS remains uncertain. Our aim was to examine the effect of VitD supplementation on CVD risk factors in MetS subjects. Material and methods: This pilot study had a PROBE (prospective, randomised, open-label, blinded end-point) design...
2017: Archives of Medical Sciences. Atherosclerotic Diseases
https://www.readbyqxmd.com/read/29238429/the-effect-of-ongoing-vitamin-d-and-low-fat-milk-intake-on-bone-metabolism-in-female-high-school-endurance-runners
#2
Aoi Ikedo, Takuma Arimitsu, Toshiyuki Kurihara, Kumiko Ebi, Satoshi Fujita
Background: Vitamin D and calcium are essential nutrients for bone health. In addition, vitamin D suppresses inflammatory cytokines and increases bone resorption. Therefore, improvements in bone health by calcium and vitamin D supplementation have the potential to not only improve calcium metabolism but also suppress inflammation associated with exercise training. The purpose of this study was to determine whether ongoing vitamin D supplementation and low-fat milk intake by female high-school endurance runners would improve bone metabolism by suppressing inflammatory cytokines and the parathyroid hormone (PTH)...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29236049/effect-of-monthly-high-dose-long-term-vitamin-d-on-lung-function-a-randomized-controlled-trial
#3
John D Sluyter, Carlos A Camargo, Debbie Waayer, Carlene M M Lawes, Les Toop, Kay-Tee Khaw, Robert Scragg
Although observational studies suggest positive vitamin D-lung function associations, randomized trials are inconsistent. We examined effects of vitamin D supplementation on lung function. We recruited 442 adults (50-84 years, 58% male) into a randomized, double-blinded, placebo-controlled trial. Participants received, for 1.1 years (median; range = 0.9-1.5 years), either (1) vitamin D₃ 200,000 IU, followed by monthly 100,000 IU doses (n = 226); or (2) placebo monthly (n = 216). At baseline and follow-up, spirometry yielded forced expiratory volume in 1 s (FEV1; primary outcome)...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29234503/study-protocol-for-a-phase-ii-dose-evaluation-randomized-controlled-trial-of-cholecalciferol-in-critically-ill-children-with-vitamin-d-deficiency-vitdal-picu-study
#4
Dayre McNally, Karin Amrein, Katharine O'Hearn, Dean Fergusson, Pavel Geier, Matt Henderson, Ali Khamessan, Margaret L Lawson, Lauralyn McIntyre, Stephanie Redpath, Hope A Weiler, Kusum Menon
Background: Clinical research has recently demonstrated that vitamin D deficiency (VDD) is highly prevalent in the pediatric intensive care unit (PICU) and associated with worse clinical course. Multiple adult ICU trials have suggested that optimization of vitamin D status through high-dose supplementation may reduce mortality and improve other clinically relevant outcomes; however, there have been no trials of rapid normalization in the PICU setting. The objective of this study is to evaluate the safety and efficacy of an enteral weight-based cholecalciferol loading dose regimen in critically ill children with VDD...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29226640/association-of-paraoxonase-1-polymorphism-and-serum-25-hydroxyvitamin-d-with-the-risk-of-cardiovascular-disease-in-patients-with-rheumatoid-arthritis
#5
Sawsan O Khoja, Yasser El Miedany, Archana P Iyer, Sami M Bahlas, Khadijah S Balamash, Mohamed F Elshal
BACKGROUND: Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality that are not accounted for by traditional risk factors alone. Paraoxonase 1 (PON1) and 25-hydroxyvitamin D have been shown to be involved in the pathogenesis of CV diseases. Objective: This study aimed to investigate PON1 gene polymorphism and serum 25-hydroxyvitamin D concentrations in RA patients, and to determine their association with CV risk in RA. METHODS: Serum samples from 46 RA patients and 45 healthy controls were tested for PON1 R192Q genotypes and serum vitamin D concentrations...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29220424/genetically-deprived-vitamin-d-exposure-predisposes-to-atrial-fibrillation
#6
Yap-Hang Chan, Kai-Hang Yiu, Jo Jo Hai, Pak-Hei Chan, Tai-Hing Lam, Ben J Cowling, Pak-Chung Sham, Chu-Pak Lau, Karen Siu-Ling Lam, Chung-Wah Siu, Hung-Fat Tse
Aims: Low vitamin D level is associated with atrial fibrillation (AF) and may be implicated in its pathogenesis. Methods and results: We studied single nucleotide polymorphisms (SNPs) of vitamin D mechanistic pathways and serum 25-hydroxyvitamin D [25(OH)D] levels in an age- and gender-matched case-control study (controls without AF: mean age 68.6 ± 8.7 years, female 25%; n = 1019; with AF: mean age 69.7 ± 9.5 years, female 30%; n = 156) recruited from a Chinese clinical cohort of patients with stable coronary artery disease...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29217650/serum-and-urine-vitamin-d-metabolite-analysis-in-early-preeclampsia
#7
Jennifer Tamblyn, Carl Jenkinson, Dean Larner, Martin Hewison, Mark Kilby
Vitamin D-deficiency is common in pregnant women, and may contribute to adverse events in pregnancy such as preeclampsia (PET). To date, studies of vitamin D and PET have focused primarily on serum concentrations vitamin D, 25-hydroxyvitamin D3 (25(OH)D3) later in pregnancy. The aim here was to determine whether a more comprehensive analysis of vitamin D metabolites earlier in pregnancy could provide predictors of PET. Using samples from the SCOPE pregnancy cohort, multiple vitamin D metabolites were quantified by liquid chromatography-tandem mass spectrometry in paired serum and urine prior to the onset of PET symptoms...
December 7, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29216203/dose-responses-of-vitamin-d3-supplementation-on-arterial-stiffness-in-overweight-african-americans-with-vitamin-d-deficiency-a-placebo-controlled-randomized-trial
#8
Anas Raed, Jigar Bhagatwala, Haidong Zhu, Norman K Pollock, Samip J Parikh, Ying Huang, Robyn Havens, Ishita Kotak, De-Huang Guo, Yanbin Dong
BACKGROUND: Clinical trials are scant and equivocal on whether vitamin D can ameliorate arterial stiffness, particularly in populations at high risk for vitamin D deficiency and cardiovascular disease (CVD). This study determined the dose-response effects of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency. METHODS: Seventy overweight African Americans (aged 13-45 years) with serum 25-hydroxyvitamin D [25(OH)D] levels ≤ 20 ng/mL were randomized to monthly oral supplementation of 18,000 IU (~600 IU/day, n = 17), 60,000 IU (~2000 IU/day, n = 18), or 120,000 IU (~4000 IU/day, n = 18) of vitamin D3 or placebo (n = 17) for 16-weeks...
2017: PloS One
https://www.readbyqxmd.com/read/29212985/bone-formation-parameters-of-the-biopsied-ilium-differ-between-subtrochanteric-and-diaphyseal-atypical-femoral-fractures-in-bisphosphonate-treated-patients
#9
Naoki Kondo, Tomomi Fukuhara, Yo Watanabe, Dai Miyasaka, Noriaki Yamamoto, Hiroe Sato, Yoko Wada, Takeshi Nakatsue, Junichi Fujisawa, Mayumi Sakuma, Norio Imai, Takuya Yoda, Ichiei Narita, Naoto Endo
Atypical femoral fractures (AFFs) are defined as atraumatic or low-trauma fractures located in the subtrochanteric or diaphyseal sites. Long-term bisphosphonates (BPs) are administered to prevent fragility fractures in patients with primary osteoporosis or collagen diseases who are already taking glucocorticoids (GCs). Long-term BP use is one of the most important risk factors for AFFs. Its pathogenesis is characterized by severely suppressed bone turnover (SSBT), but whether the characteristics of patients are different regarding to location of fracture site remains unknown...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29212772/modifiable-pathways-in-alzheimer-s-disease-mendelian-randomisation-analysis
#10
Susanna C Larsson, Matthew Traylor, Rainer Malik, Martin Dichgans, Stephen Burgess, Hugh S Markus
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's disease. DESIGN: Mendelian randomisation study using genetic variants associated with the modifiable risk factors as instrumental variables. SETTING: International Genomics of Alzheimer's Project. PARTICIPANTS: 17 008 cases of Alzheimer's disease and 37 154 controls...
December 6, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29212579/time-course-of-vitamin-d-depletion-and-repletion-in-reproductive-age-female-c57bl-6-mice
#11
Anthony M Belenchia, Sarah A Johnson, Alyssa C Kieschnick, Cheryl S Rosenfeld, Catherine A Peterson
The use of animal models in vitamin D deficiency (VDD) research, particularly in regard to maternal deficits, has increased dramatically, yet these studies may be confounded due to ill-conceived experimental timelines. We conducted 2 experiments to (1) characterize the time course of VDD induction and repletion and (2) explore the long-term consequences of VDD on calcium homeostasis and body composition in reproductive-age female mice. Eight-week-old female C57BL/6 mice were randomized to receive either a vitamin D sufficient (VDS) or VDD diet; serum was collected weekly...
December 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/29212401/evaluating-the-effects-of-administration-of-25-hydroxyvitamin-d-supplement-on-serum-anti-mullerian-hormone-amh-levels-in-infertile-women
#12
Zahra Naderi, Maryam Kashanian, Leily Chenari, Narges Sheikhansari
The aim of the study was to evaluate the effects of administration of 25-hydroxyvitamin D [25(OH) D] on serum antimullerian hormone (AMH) levels in infertile women. The study was performed as a non-randomized clinical trial on 30 infertile women who had low serum level of both 25(OH) D and anti-mullerian hormone. Vitamin D was prescribed 50,000 IU weekly for up to three months for all eligible participants. Serum levels of both 25(OH) D and AMH have increased significantly after treatment with 25(OH) D. There was a significant correlation between serum levels of 25(OH) D after treatment with AMH (p = ...
December 6, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29207490/is-trabecular-bone-score-valuable-in-bone-microstructure-assessment-after-gastric-bypass-in-women-with-morbid-obesity
#13
Agustina Pia Marengo, Fernando Guerrero Pérez, Luis San Martín, Rosa Monseny, Anna Casajoana, Rocio Valera, Nuria Virgili, Andreu Simó Servat, Albert Prats, Carmen Gómez-Vaquero, Nuria Vilarrasa
INTRODUCTION: The effects of bariatric surgery on skeletal health raise many concerns. Trabecular bone score (TBS) is obtained through the analysis of lumbar spine dual X-ray absorptiometry (DXA) images and allows an indirect assessment of skeletal microarchitecture (MA). The aim of our study was to evaluate the changes in bone mineral density (BMD) and alterations in bone microarchitecture assessed by TBS in morbidly obese women undergoing Roux-en-Y gastric bypass (RYGB), over a three-year follow-up...
December 2, 2017: Nutrients
https://www.readbyqxmd.com/read/29204369/effect-of-a-vitamin-and-mineral-supplementation-on-glycemic-status-results-from-a-community-based-program
#14
Samantha M Kimball, J C Herbert Emery, Richard Z Lewanczuk
Aims: Diet is a major risk factor for type 2 diabetes mellitus. As cofactors necessary for enzyme function of all metabolic pathways, vitamins and minerals have the potential to improve glucose metabolism. We investigated the effects of a nutrient intervention program on glycemic status. Methods: We used a form of natural experiment to compare Pure North program participants (n = 1018) that received vitamin D alone (Vital 1) or vitamin D in combination with other nutrients (Vital 2) during two different time periods...
December 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29201206/combined-treatment-of-diabetic-nephropathy-with-alprostadil-and-calcium-dobesilate
#15
Lili Qin, Wenjun Qin, Jianfei Wang, Lin Lin
This study investigated the effects of alprostadil combined with calcium dobesilate on the treatment of diabetic nephropathy. We recruited 80 patients with diabetic nephropathy, who were randomly divided into experimental (n=40) and control (n=40) groups. Patients received high-quality low-protein diabetic diet intervention and subcutaneous injection of insulin to adjust blood glucose, combined with antihypertensive, antiplatelet drugs, and other comprehensive treatments. The control group received alprostadil and the experimental group received alprostadil combined with calcium dobesilate...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29196501/vitamin-d-binding-protein-rs7041-genotype-alters-vitamin-d-metabolism-in-pregnant-women
#16
Ariel B Ganz, Heyjun Park, Olga V Malysheva, Marie A Caudill
Research has identified reduced circulating 25-hydroxyvitamin D [25(OH)D] in individuals with the rs7041 (c.1296T>G) T allele in the vitamin D binding protein gene (GC); however, the effects of the T allele on vitamin D biomarkers during pregnancy and lactation are unknown. Thus, we examined the metabolic effects of GC rs7041 on vitamin D biomarkers among third-trimester pregnant (n = 26), lactating (n = 28), and nonpregnant/nonlactating (n = 21) women consuming a single amount of vitamin D (511 IU/d) and related nutrients for 10-12 wk...
December 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29192637/predictors-of-vitamin-d-deficiency-in-predialysis-patients-with-stage-3-5-chronic-kidney-diseases-in-southern-china
#17
M Feng, J Lv, F T Huang, P F Liang, S Fu, Y C Zeng, Y Tang, A P Xu
OBJECTIVE: Vitamin D status and risk factors of Vitamin D deficiency in chronic kidney disease (CKD) patients in China have been seldom reported before. In this study, we aim to investigate serum 25-hydroxyvitamin D [25(OH)D] status and find the predictors of Vitamin D deficiency in predialysis patients with Stage 3-5 CKDs in Southern China. METHODS: In this retrospective cross-sectional study, hospitalized predialysis patients who were diagnosed of Stage 3-5 CKD and had taken measurement of serum 25(OH)D in a single center from January 2014 to June 2015 were included...
October 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29188894/vitamin-d-and-the-mechanisms-circumstances-and-consequences-of-falls-in-older-adults-a-case-control-study
#18
G T Duval, P-Y Paré, J Gautier, S Walrand, M Dinomais, C Annweiler
OBJECTIVES: To determine i) whether cases of elderly fallers had lower serum 25-hydroxyvitamin D (25OHD) concentration than controls without history of falls; and ii) whether serum 25OHD concentration was associated with specific mechanisms, circumstances and consequences of falls. DESIGN: Case-control study with a 1:2 ratio. SETTING: Geriatric ward of the University Hospital of Angers, France, between February 2012 and March 2014. PARTICIPANTS: 216 inpatients (72 cases and 144 age- and gender-matched controls)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29188877/vitamin-d-status-and-elevated-red-cell-distribution-width-in-community-dwelling-adults-results-from-the-national-health-and-nutrition-examination-survey-2001-2006
#19
T M N Otero, D J Monlezun, K B Christopher, C A Camargo, S A Quraishi
OBJECTIVES: Elevated red cell distribution width (RDW) is associated with morbidity and mortality in community-dwelling individuals. Although RDW is traditionally used to diagnose anemia, it may also be a marker of systemic inflammation. Since vitamin D is a potent modulator of inflammatory cytokines our goal was to investigate whether 25-hydroxyvitamin D levels (25OHD) are associated with RDW in non-hospitalized adults. DESIGN: To investigate this association, we conducted a cross-sectional study...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29188857/assessing-the-relationship-between-vitamin-d-status-and-impairments-in-cognitive-and-physical-performance-in-older-adults-using-a-dual-task-physical-performance-test
#20
J Lopez, A Campa, J E Lewis, F G Huffman, J P Liuzzi, T Li, A H Martinez, S M Ferris, A Rasul, A Farooqi, A M Lopez Medrano, S E Atlas, E Tiozzo, J Konefal, J M Woolger
BACKGROUND: Vitamin D deficiency has been associated with an increased risk of falls in older adults. Several studies have demonstrated an association between vitamin D deficiency and gait and cognitive impairments, which are two risk factors for falls in the elderly. There is lack of research about the role of vitamin D in cognitive function in the context of mobility. OBJECTIVE: The purpose of this study was to evaluate the association between vitamin D status with the age-related changes in mobility through higher order cognitive function using a dual task physical performance test...
2017: Journal of Prevention of Alzheimer's Disease
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