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1,25 hydroxyvitamin D

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https://www.readbyqxmd.com/read/28538395/palisaded-neutrophilic-and-granulomatous-dermatitis-as-a-novel-cause-of-hypercalcemia-a-case-report
#1
Michihito Kono, Tomoka Hasegawa, So Nagai, Toshio Odani, Kazumasa Akikawa, Yukiko Nomura, Hidetsugu Sato, Keisuke Kikuchi, Norio Amizuka, Hideaki Kikuchi
RATIONALE: Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a benign, inflammatory dermatosis with distinct histopathological features often observed in patients with systemic diseases. There were no reports of PNGD without underlying systemic diseases as an underlying cause of hypercalcemia. Herein, we report a case of a 62-year-old man with hypercalcemia due to PNGD, but with no underlying systemic diseases, including tuberculosis, sarcoidosis, or vasculitis. PATIENT CONCERNS: Laboratory tests showed an elevated C-reactive protein level, an elevated corrected calcium level, a normal 25-hydroxyvitamin D level, and an elevated 1,25-dihydroxyvitamin D level...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28533007/free-25-oh-d-concentrations-are-associated-with-atopy-and-lung-function-in-children-with-asthma
#2
Suzanne L Pollard, John J Lima, Edward Mougey, Karina Romero, Carla Tarazona-Meza, Katherine Tomaino, Gary Malpartida Guzmán, Nadia N Hansel, William Checkley
BACKGROUND: Evidence suggests free mono-hydroxyvitamin D (25[OH]D) concentrations are more strongly linked to certain outcomes than total concentrations; however, no studies have examined the relation between free 25(OH)D and respiratory or allergic disease. OBJECTIVE: To examine associations between total and free 25(OH)D concentrations and asthma outcomes. METHODS: We quantified total and free 25(OH)D concentrations in 137 Peruvian children with asthma and 152 children without asthma and examined associations with asthma outcomes...
May 19, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28531780/vitamin-d-status-and-the-effects-of-oral-vitamin-d-treatment-in-children-with-vitiligo-a-prospective-study
#3
Gülay Karagüzel, Nil P Sakarya, Sevgi Bahadır, Selçuk Yaman, Ayşenur Ökten
BACKGROUND & AIMS: Vitiligo is a pigmentary disorder and autoimmune pathogenesis seems most likely. Decreased vitamin D levels have been related to several autoimmune diseases. Little is known about the association of vitiligo and vitamin D. We aimed to evaluate serum 25-hydroxyvitamin D [25(OH)D] levels in children with vitiligo and to determine the efficacy of oral vitamin D therapy on the repigmentation of vitamin D deficient patients. METHODS: Thirty patients aged 6-17 years with vitiligo and 30 sex- and age-matched apparently healthy controls were included in this prospective study...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28526533/serum-25-hydroxyvitamin-d-deficiency-predicts-long-term-poor-prognosis-among-ischemic-stroke-patients-without-hyperglycaemia
#4
Tian Xu, Chongke Zhong, Tan Xu, Yanbo Peng, Xiaoqing Bu, Chung-Shiuan Chen, Jinchao Wang, Zhong Ju, Qunwei Li, Deqin Geng, Yingxian Sun, Dongsheng Zhang, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND: It is unclear whether 25-hydroxyvitamin D [25(OH)D] has a protective effect on long-term prognosis of ischemic stroke and whether it is affected by blood glucose levels. We aim to examine the effect of serum vitamin D especially its deficiency on 1-year poor outcome of ischemic stroke patients in total patients and by blood glucose subgroups. METHODS: A total of 3041 ischemic patients from China Antihypertensive Trial in Acute Ischemic Stroke were included...
May 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28526388/serum-vitamin-d-and-change-in-lipid-levels-over-5%C3%A2-y-the-atherosclerosis-risk-in-communities-study
#5
Kamil F Faridi, Di Zhao, Seth S Martin, Joshua R Lupton, Steven R Jones, Eliseo Guallar, Christie M Ballantyne, Pamela L Lutsey, Erin D Michos
OBJECTIVES: Deficiency of 25-hydroxyvitamin D (25[OH]D) is associated with increased risk for cardiovascular disease, perhaps mediated through dyslipidemia. Deficient 25(OH)D is cross-sectionally associated with dyslipidemia, but little is known about longitudinal lipid changes. The aim of this study was to determine the relationship of 25(OH)D deficiency to longitudinal lipid changes and risk for incident dyslipidemia. METHODS: This was a longitudinal community-based study of 13 039 participants from the ARIC (Atherosclerosis Risk in Communities) study who had 25(OH)D and lipids measured at baseline (1990-1992) and lipids remeasured in 1993 to 1994 and 1996 to 1998...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28519964/association-between-serum-25-hydroxyvitamin-d-and-glycated-hemoglobin-levels-in-type-2-diabetes-patients-with-chronic-kidney-disease
#6
Lee Ling Lim, Yong Muh Ng, Pei San Kang, Soo Kun Lim
AIMS/INTRODUCTION: Vitamin D is suggested to influence glucose homeostasis. An inverse relationship between serum 25-hydroxyvitamin D [25(OH)D] and glycemic control in non-chronic kidney disease (CKD) patients with type 2 diabetes (T2D) was reported. We aimed to examine this association among T2D patients with CKD. MATERIALS AND METHODS: 100 T2D participants with stage 3-4 CKD were recruited. Blood for HbA1c , serum 25(OH)D, renal, and lipid profiles were drawn at enrolment...
May 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28517037/serum-phosphate-is-related-to-adiposity-in-healthy-adults
#7
Emma O Billington, Greg D Gamble, Sarah Bristow, Ian R Reid
BACKGROUND: Inorganic phosphate is a crucial component of cellular energy metabolism. We have identified an inverse relationship between serum phosphate concentration and fat mass in a cohort of healthy men. This study reports those data and determines whether this association is present in two female populations. METHODS: Cross-sectional data from three independent cohorts, consisting of healthy adult males (Male Cohort, n=323) and healthy postmenopausal women (Female Cohort 1, n=185; and Female Cohort 2, n=1471), are reported...
May 18, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28509123/serum-calcitriol-levels-in-a-patient-with-x-linked-hypophosphatemia-complicated-by-autosomal-dominant-polycystic-kidney-disease
#8
Satomi Kajita, Takehisa Yamamoto, Naoko Tsugawa, Hirohumi Nakayama, Takuo Kubota, Toshimi Michigami, Keiichi Ozono
Serum calcitriol [1,25(OH)2D] levels are low normal in the presence of hypophosphatemia in X-linked dominant hypophosphatemic rickets (XLH) due to elevated serum fibroblast growth factor 23 (FGF23) levels. We report a peculiar finding of markedly elevated serum 1,25(OH)2D levels in a patient with XLH complicated by autosomal dominant polycystic kidney disease (ADPKD) and retinitis pigmentosa (RP). She was diagnosed with XLH, ADPKD and RP at the age of 5, 13 and 15 years, respectively. After the diagnosis of ADPKD, the 1,25(OH)2D levels increased up to 282 pg/mL treated with a pharmacological dose of 1αOHD3 (1αOHD3)...
May 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28502105/longitudinal-changes-in-serum-25-hydroxyvitamin-d-in-the-dallas-heart-study
#9
Sasan Mirfakhraee, Colby R Ayers, Darren K McGuire, Naim M Maalouf
CONTEXT: While the prevalence of vitamin D deficiency is well described in various populations, limited data are available regarding longitudinal variation in serum 25-hydroxyvitamin D concentrations. OBJECTIVES: To evaluate the temporal trends in serum 25(OH)D, prevalence of vitamin D deficiency, and factors influencing these trends. PARTICIPANTS, DESIGN AND SETTING: Adults enrolled in the Dallas Heart Study, a longitudinal, probability-based, multiethnic, population study in Dallas, Texas, USA...
May 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28500757/meta-analysis-of-the-effect-of-the-maternal-vitamin-d-level-on-the-risk-of-spontaneous-pregnancy-loss
#10
REVIEW
Heng Zhang, Zhaohui Huang, Limin Xiao, Xinye Jiang, Daozhen Chen, Yarong Wei
BACKGROUND: The association between vitamin D deficiency and early spontaneous pregnancy loss (SPL) is unclear. OBJECTIVES: To assess the association of serum 25-hydroxyvitamin D (25(OH)D) and SPL. SEARCH STRATEGY: Embase, PubMed, and Web of Science were searched for relevant papers published before February 20, 2016, using search terms including "vitamin D" and "pregnancy loss." SELECTION CRITERIA: Case-control and cohort studies investigating the relationship of maternal serum 25(OH)D and SPL were included...
May 13, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28498942/effect-of-vitamin-d-on-all-cause-mortality-in-heart-failure-evita-a-3-year-randomized-clinical-trial-with-4000%C3%A2-iu-vitamin-d-daily
#11
Armin Zittermann, Jana B Ernst, Sylvana Prokop, Uwe Fuchs, Jens Dreier, Joachim Kuhn, Cornelius Knabbe, Ingvild Birschmann, Uwe Schulz, Heiner K Berthold, Stefan Pilz, Ioanna Gouni-Berthold, Jan F Gummert, Marcus Dittrich, Jochen Börgermann
Aims: Circulating 25-hydroxyvitamin D (25OHD) levels <75 nmol/L are associated with a nonlinear increase in mortality risk. Such 25OHD levels are common in heart failure (HF). We therefore examined whether oral vitamin D supplementation reduces mortality in patients with advanced HF. Methods and results: Four hundred HF patients with 25OHD levels <75 nmol/L were randomized to receive 4000 IU vitamin D daily or matching placebo for 3 years. Primary endpoint was all-cause mortality...
May 12, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28493652/vitamin-d-deficiency-associated-with-cognitive-functioning-in-psychotic-disorders
#12
Mari Nerhus, Akiah O Berg, Carmen Simonsen, Marit Haram, Beathe Haatveit, Sandra R Dahl, Tiril P Gurholt, Thomas D Bjella, Torill Ueland, Ole A Andreassen, Ingrid Melle
BACKGROUND: Cognitive dysfunctions are core features of psychotic disorders with substantial impact on daily functioning. Vitamin D deficiency has been found to be related to cognitive dysfunctions, but the associations between vitamin D deficiency and cognition in persons with a psychotic disorder are largely unknown. METHODS: This cross-sectional study included 225 patients with a DSM-IV psychotic disorder consecutively recruited from 2003 to 2014 and 159 randomly selected healthy controls, assessed by a cognitive test battery, a clinical protocol (including Structured Clinical Interview for DSM-IV Axis I Disorders and Positive and Negative Syndrome Scale), and a physical examination including vitamin D measurements...
May 9, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28492394/sub-saharan-african-migrants-have-slower-initial-cd4-cell-recovery-after-combined-antiretroviral-treatment-initiation-than-french-natives
#13
Rémonie Seng, Mathilde Ghislain, Pierre-Marie Girard, Laurent Cotte, Agnès Meybeck, François Raffi, Sophie Abgrall, Yazdan Yazdanpanah, Cécile Goujard, Rosemary Dray-Spira, Laurence Meyer
OBJECTIVE: Poorer immunologic responses to combined antiretroviral treatment (cART) have been reported among sub-Saharan African (SSA) migrants than among native Europeans. We studied whether differences in CD4 cell recovery between French natives and SSA migrants starting first-line cART could be explained by differences in socioeconomic conditions, inflammatory marker levels, and other established determinants. METHODS: We compared 319 French natives and 175 SSA migrants (ANRS-COPANA cohort)...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28492143/a-direct-assay-for-measuring-free-25-hydroxyvitamin-d
#14
Heureux Nicolas, Ernst Lindhout, Leon Swinkels
Recent studies suggest that the concentration and genotype of vitamin D binding protein (VDBP) are important factors that determine the bioavailability of 25-hydroxyvitamin D [25(OH)D] in blood. Accumulating data indicate that, e.g., in pregnant women, hemodialysis patients, chronic kidney disease, liver failure, and bladder and pancreatic cancers, the measurement of free 25(OH)D in serum provides more relevant diagnostic information than measurement of total 25(OH)D. The aim of this study was to develop and validate an ELISA for direct measurement of free 25(OH)D in serum...
May 11, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28492140/high-dose-intramuscular-vitamin-d-provides-long-lasting-moderate-increases-in-serum-25-hydroxvitamin-d-levels-and-shorter-term-changes-in-plasma-calcium
#15
Shelley Gorman, Mark Zafir, Ee Mun Lim, Michael W Clarke, Gursimran Dhamrait, Naomi Fleury, John P Walsh, Martin Kaufmann, Glenville Jones, Robyn M Lucas
The best management of vitamin D deficiency, defined as a 25-hydroxyvitamin D [(25(OH)D] level <50 nM, is unclear. Intramuscular (IM) injection of a large bolus of vitamin D (≥100 000 IU) is used, but its safety is uncertain. In 10 adults given an IM injection of 600 000IU vitamin D₃, we measured at baseline and at 1, 2, 3, and 4 weeks postinjection the serum levels of vitamin D₃, 25(OH)D₃, 25(OH)D₂, total 25(OH)D, 3-epi-25(OH)D₃, and 24,25-dihydroxyvitamin D₃ [24,25(OH)₂D₃] using a standardized LC with tandem MS (MS/MS) assay; serum levels of 25(OH)D using the Abbott ARCHITECT i2000 immunoassay; and markers of bone metabolism...
May 11, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28492134/simplified-25-hydroxyvitamin-d-standardization-and-optimization-in-dried-blood-spots-by-lc-ms-ms
#16
Andrew J Makowski, John A Rathmacher, Ronald L Horst, Christopher T Sempos
Previous studies have assessed vitamin D status based on the 25-hydroxyvitamin D [25(OH)D] concentration measured in samples from dried blood spots (DBSs). In 40 individuals participating in a clinical study, we compared 25(OH)D levels measured from DBSs and in serum using an LC-MS/MS reference procedure in collaboration with the Vitamin D Standardization Program. The main objective was to simplify and optimize current methods to produce an assay that can be used as a screening tool for 25(OH)D concentration assessment without derivatization...
May 11, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28491910/social-disadvantage-is-associated-with-lower-vitamin-d-levels-in-older-people-and-there-is-no-surrogate-for-its-measurement
#17
Adrian H Heald, Simon G Anderson, Jonathan J Scargill, Andrea Short, David Holland, Adnan Khan, Anthony A Fryer, Rachelle P Donn, Mark Livingston
Introduction: There is increasing evidence concerning adverse health consequences of low vitamin D levels. We determined whether there is any surrogate for measuring vitamin D in people older than 70 years and the relation between index of multiple deprivation (IMD) and vitamin D levels. Methods: Blood samples from 241 patients were included in this analysis. Concurrent measurements for 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), and bone profile are reported. Results: The prevalence of total vitamin D insufficiency/deficiency (defined as total vitamin D <50 nmol/L) was 57...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/28491335/the-risk-of-acute-rejection-following-kidney-transplant-by-25-hydroxyvitamin-d-and-1-25-dihydroxyvitamin-d-status-a-prospective-cohort-study
#18
Deborah Zimmerman, Andrew A House, S Joseph Kim, Ronald A Booth, Tinghua Zhang, Tim Ramsay, Greg Knoll
BACKGROUND: Prediction of acute kidney transplant rejection remains imperfect despite several known risk factors. There is an increasing appreciation of the potential importance of the vitamin D pathway in immunological disease and transplantation. OBJECTIVE: The purpose of this study was to determine the association of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with acute rejection. DESIGN: This was a prospective cohort study. SETTING: Three academic adult kidney transplant programs in Ontario, Canada, were chosen...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28490514/vitamin-d-supplementation-has-no-effect-on-insulin-sensitivity-or-secretion-in-vitamin-d-deficient-overweight-or-obese-adults-a-randomized-placebo-controlled-trial
#19
Aya Mousa, Negar Naderpoor, Maximilian Pj de Courten, Helena Teede, Nicole Kellow, Karen Walker, Robert Scragg, Barbora de Courten
Background: Vitamin D supplementation has been proposed as a potential strategy to prevent type 2 diabetes. Existing clinical trials have been limited by short duration, low doses of vitamin D, variability in participants' vitamin D-deficiency status, and the use of surrogate measures of body composition, insulin sensitivity, and insulin secretion.Objective: To address existing knowledge gaps, we conducted a double-blind, randomized, placebo-controlled trial to investigate whether vitamin D supplementation that is provided in a sufficient dose and duration to vitamin D-deficient individuals would improve insulin sensitivity or secretion as measured with the use of gold-standard methods...
May 10, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28490509/vitamin-d-and-calcium-intake-and-risk-of-early-menopause
#20
Alexandra C Purdue-Smithe, Brian W Whitcomb, Kathleen L Szegda, Maegan E Boutot, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Lisa M Troy, Karin B Michels, Elizabeth R Bertone-Johnson
Background: Early menopause, defined as the cessation of ovarian function before the age of 45 y, affects ∼10% of women and is associated with higher risk of cardiovascular disease, osteoporosis, and other conditions. Few modifiable risk factors for early menopause have been identified, but emerging data suggest that high vitamin D intake may reduce risk.Objective: We evaluated how intakes of vitamin D and calcium are associated with the incidence of early menopause in the prospective Nurses' Health Study II (NHS2)...
May 10, 2017: American Journal of Clinical Nutrition
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