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Thaís Silva Barroso, Marcelo Cortês Cavalcante, João Baptista Gomes Dos Santos, João Carlos Belloti, Flávio Faloppa, Vinícius Ynoe de Moraes
BACKGROUND: Hierarchy of evidence is an important measurement for assessing quality of literature. Information regarding quality of evidence within the Brazilian hand surgery setting is sparse, especially regarding whether research has improved in either quality or quantity. This study aimed to identify and classify hand surgery studies published in the two most important Brazilian orthopedics journals based on hierarchy of evidence, with comparisons with previously published data. DESIGN AND SETTING: Bibliometric analysis study performed in a federal university...
November 17, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
Talal Ibrahim, Osama M S Aldahamsheh, Abdelsalam Hegazy, Hassan M K Ghomrawi
PURPOSE: The appropriate-use criteria (AUC) for distal radius fracture (DRF) was developed by the American Academy of Orthopedic Surgeons (AAOS) to aid surgeons in making evidence-based treatment decisions for DRFs. The aim of our study was to cross-reference the management of operatively treated DRFs with the web-based AAOS published AUC recommendations. METHODS: The AUC for DRF evaluates the appropriateness of ten treatment options for each of 240 mutually exclusive patient scenarios based on the combination of five factors...
November 20, 2017: International Orthopaedics
Pramod Thomas, Fanyin He, Sati Mazumdar, Joel Wood, Triptish Bhatia, Ruben C Gur, Raquel E Gur, Daniel Buysse, Vishwajit L Nimgaonkar, Smita N Deshpande
BACKGROUND: Impairment in cognitive variables and alterations in circadian function have been documented among patients with schizophrenia (SZ) and bipolar I disorder (BP1), but it is not known whether joint analysis of these variables can define clinically relevant sub-groups in either disorder. OBJECTIVES: To evaluate the pattern and relationship of cognitive and circadian function in SZ and BP1 patients with respect to diagnosis and indices of clinical severity...
November 7, 2017: Asian Journal of Psychiatry
Prethy Rao, Flora Lum, Kevin Wood, Craig Salman, Bhavya Burugapalli, Rebecca Hall, Sukhminder Singh, David W Parke, George A Williams
PURPOSE: The purpose of this study is to compare real-world visual acuity (VA) in patients with neovascular age-related macular degeneration (nAMD) treated with a single anti-vascular endothelial growth factor (VEGF) drug monotherapy for 1 year from the American Academy of Ophthalmology (AAO) Intelligent Research in Sight (IRIS) Registry. DESIGN: Retrospective, nonrandomized, comparative study. PARTICIPANTS: IRIS Registry patients with nAMD who received bevacizumab, ranibizumab, or aflibercept only for 1 year between 2013-2016...
November 13, 2017: Ophthalmology
Seyed Mohsen Hosseini, Vahid Pirouzfar, Hamed Azami
In the present work, vertically aligned carbon nanotube (VA-CNT) sheets were synthesized via pyrolysis of polybenzimidazole (PBI)-Kapton inside the pores of anodized aluminum oxide (AAO). The synthesized VA-CNT sheets were then evaluated for the desalination of salty water. The results indicated that the VA-CNT sheets were effective for application as an adsorbent for desalination of salty water due to their high adsorption capacity, with no loss of CNTs in the treated water. This study explored the impact of operating time and temperature on liquid adsorption performance through optimization and modeling methods...
November 10, 2017: Journal of Membrane Biology
Chen Zhang, Ye Sha, Yue Zhang, Ting Cai, Linling Li, Dongshan Zhou, Xiaoliang Wang, Gi Xue
The production and stabilization of amorphous drugs by the nanoconfinement effect has recently become a research hotspot in pharmaceutical sciences. Herein, two guest/host systems, indomethacin (IMC) and griseofulvin (GSF) confined in anodic aluminum oxide (AAO) templates with different pore diameters (25-250 nm) are investigated by differential scanning calorimetry (DSC) and broadband dielectric spectroscopy (BDS). The crystallization of the confined drugs is suppressed, and their glass transition temperatures show an evident pore-size dependency...
November 17, 2017: Journal of Physical Chemistry. B
Daria Feldman, David J Kowbel, N Louise Glass, Oded Yarden, Yitzhak Hadar
Small secreted proteins (SSPs), along with lignocellulose degrading enzymes, are integral components of the secretome of Pleurotus ostreatus, a white rot fungus. In this study, we identified 3 genes (ssp1, 2 and 3) encoding proteins that are annotated as SSPs and that exhibited of ~4,500- fold expression, 24 hr following exposure to the toxic compound 5-hydroxymethylfurfural (HMF). Homologues to genes encoding these SSPs are present in the genomes of other basidiomycete fungi, however the role of SSPs is not yet understood...
November 6, 2017: Scientific Reports
Sukgi Choi, Lorraine Nnacheta
The American Academy of Otolaryngology-Head and Neck Surgery has been developing clinical practice guidelines (CPGs) for use by its members and the public. The process of CPG development and the selection of topics for CPGs can be confusing. This commentary attempts to clarify this process and delineate the issues that are considered in topic selection.
October 1, 2017: Otolaryngology—Head and Neck Surgery
Ryohei Oya, Takao Imai, Takashi Sato, Atsuhiko Uno, Yoshiyuki Watanabe, Suzuyo Okazaki, Yumi Ohta, Tadashi Kitahara, Arata Horii, Hidenori Inohara
OBJECTIVE: The presence of endolymphatic hydrops in the inner ear, which can be detected with gadolinium-enhanced magnetic resonance imaging (Gd-MRI), is widely recognized as the main pathological cause of Ménière's disease (MD). However, the precise mechanisms underlying the development of endolymphatic hydrops remains unclear. One hypothesis proposes a relationship between the presence of a high jugular bulb (HJB) and MD, which disrupts the vestibular aqueduct leading to the development of endolymphatic hydrops...
October 19, 2017: Auris, Nasus, Larynx
Healin Im, Seok Hwan Jeong, Dong Hyuk Park, Sunkook Kim, Young Ki Hong
After reporting on the two-step anodization, nanoporous anodic aluminum oxides (AAOs) have been widely utilized in the versatile fields of fundamental sciences and industrial applications owing to their periodic arrangement of nanopores with relatively high aspect ratio. However, the techniques reported so far, which could be only valid for mono-surface anodization, show critical disadvantages, i.e., time-consuming as well as complicated procedures, requiring toxic chemicals, and wasting valuable natural resources...
October 5, 2017: Journal of Visualized Experiments: JoVE
Juan Carro, Marta Martínez-Júlvez, Milagros Medina, Angel T Martínez, Patricia Ferreira
The temperature dependence of hydride transfer from the substrate to the N5 of the FAD cofactor during the reductive half-reaction of Pleurotus eryngii aryl-alcohol oxidase (AAO) is assessed here. Kinetic isotope effects on both the pre-steady state reduction of the enzyme and its steady-state kinetics, with differently deuterated substrates, suggest an environmentally-coupled quantum-mechanical tunnelling process. Moreover, those kinetic data, along with the crystallographic structure of the enzyme in complex with a substrate analogue, indicate that AAO shows a pre-organized active site that would only require the approaching of the hydride donor and acceptor for the tunnelled transfer to take place...
November 1, 2017: Physical Chemistry Chemical Physics: PCCP
Meng-Xi Yang, Zhi-Gang Yang, Yi Zhang, Ke Shi, Hua-Yan Xu, Kai-Yue Diao, Ying-Kun Guo
To explore the accuracy of main pulmonary artery (MPA) and ascending aorta (AAO) image evaluation in pediatric patients with single ventricle (SV) by comparing dual-source computed tomography (DSCT) with echocardiography. Thirty-one children with SV were retrospectively enrolled. The stenosis, dilation, and location of MPA and AAO were independently evaluated by DSCT and echocardiography. The accompanying arterial malformations were also assessed by DSCT. For 17 patients undergoing cardiac catheterization, the DSCT-based diameters of MPA and AAO were correlated with their pressures as measured by catheterization...
October 17, 2017: Scientific Reports
Chao Song, Xiangchen Che, Long Que
In this paper, a drug loading and release device fabricated using nanopore thin film and layer-by-layer (LbL) nanoassembly is reported. The nanopore thin film is a layer of anodic aluminum oxide (AAO), consisting of honeycomb-shape nanopores. Using the LbL nanoassembly process, the drug, using gentamicin sulfate (GS) as the model, can be loaded into the nanopores and the stacked layers on the nanopore thin film surface. The drug release from the device is achieved by immersing it into flowing DI water. Both the loading and release processes can be monitored optically...
August 7, 2017: Optics Express
Yang Chen, Chun Xu, Sam Harirforoosh, Xingguang Luo, Ke-Sheng Wang
The human receptor-type protein-tyrosine phosphatase kappa (PTPRK) gene is highly expressed in human brain and was previously associated with an increased risk of neuropsychiatric disorders and cancer. This study investigated the association of 52 single nucleotide polymorphisms (SNPs) in PTPRK with the risk and age at onset (AAO) of Alzheimer's disease (AD) in 791 AD patients and 782 controls. Our data analysis showed that five SNPs (top SNP rs4895829 with p = 0.0125) were associated with the risk of AD based on a multiple logistic regression (p < 0...
September 27, 2017: Journal of Psychiatric Research
María Laura Lastra, María Silvina Molinuevo, Iwona Blaszczyk-Lezak, Carmen Mijangos, María Susana Cortizo
In the tissue engineering field the design of the scaffold inspired on the natural occurring tissue is of vital importance. Ideally, the scaffold surface must promote cell growth and differentiation, while promote angiogenesis in the in vivo implant of the scaffold. On the other hand, the material selection must be biocompatible and the degradation times should meet tissue reparation times. In the present work, we developed a nanofibrous scaffold based on chitosan crosslinked with diisopropylfumarate-vinyl acetate copolymer using anodized aluminum oxide (AAO) templates...
October 6, 2017: Journal of Biomedical Materials Research. Part A
Sebastian Z Oener, Parisa Khoram, Sarah Brittman, Sander A Mann, Qianpeng Zhang, Zhiyong Fan, Shannon W Boettcher, Erik C Garnett
The defect tolerance of halide perovskite materials has led to efficient optoelectronic devices based on thin-film geometries with unprecedented speed. Moreover, it has motivated research on perovskite nanowires because surface recombination continues to be a major obstacle in realizing efficient nanowire devices. Recently, ordered vertical arrays of perovskite nanowires have been realized, which can benefit from nanophotonic design strategies allowing precise control over light propagation, absorption, and emission...
November 8, 2017: Nano Letters
Ryan E Harold, Bennet A Butler, Joseph Lamplot, Hue H Luu, Cort D Lawton, David Manning
INTRODUCTION: We investigate the effectiveness of a comprehensive aseptic protocol in reducing surgical site infection (SSI) after hip arthroplasty in a single medical centre with a high prevalence of methicillin-resistant Staphylococcus aureus (MRSA). METHODS: A prospectively collected database of all patients undergoing hip arthroplasty in a single centre between 2005 and 2011 was reviewed for SSI using Centers for Disease Control (CDC) criteria and AAOS guidelines...
September 21, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
Xin Hao, Shengping He, Huijun Wang, Tingting Han
Increasing greenhouse gas concentration and ozone depletion are generally considered two important factors that affect the variability of the Antarctic Oscillation (AAO). Here, we find that the first leading mode of sea surface temperature (SST) variability (rotated empirical orthogonal functions) shows a long-term upward trend from 1901 to 2004 and is closely related to the AAO index that is obtained using the observationally constrained reanalysis data. Further, regressions of the sea level pressure and the 500-hPa geopotential height anomalies, against the principle component associated with the long-term SST anomalies, display a seesaw behavior between the middle and high latitudes of the Southern Hemisphere in austral winter, which is similar to the high polarity of the AAO...
September 26, 2017: Scientific Reports
Qi Hao, Hao Huang, Xingce Fan, Yin Yin, Jiawei Wang, Wan Li, Teng Qiu, Libo Ma, Paul K Chu, Oliver G Schmidt
We report on design and fabrication of patterned plasmonic dimer arrays by using an ultrathin anodic aluminum oxide (AAO) membrane as a shadow mask. This strategy allows for controllable fabrication of plasmonic dimers where the location, size, and orientation of each particle in the dimer pairs can be independently tuned. Particularly, plasmonic dimers with ultrasmall nanogaps down to the sub-10 nm scale as well as a large dimer density up to 1.0 × 10(10) cm(-2) are fabricated over a centimeter-sized area...
October 18, 2017: ACS Applied Materials & Interfaces
Yifen Lin, Yixiong Lin, Hetong Lin, Yihui Chen, Hui Wang, John Shi
Effects of propyl gallate on metabolisms of respiration and energy of harvested 'Fuyan' longans and its relationship to pericarp browning were investigated. Compared to control longans, propyl gallate could reduce ascorbic acid oxidase (AAO) activity, lower cytochrome C oxidase (CCO) activity during early-storage and mid-storage, increase NADK activity, elevate contents of NADP and NADPH, decrease contents of NAD and NADH, in addition, lower the decreases of ATP content and energy charge (E.C.), increase activities of mitochondrial H(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase during early-storage and mid-storage...
February 1, 2018: Food Chemistry
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