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https://www.readbyqxmd.com/read/29327165/measurement-of-cardiac-valve-and-aortic-blood-flow-velocities-in-stroke-patients-a-comparison-of-4d-flow-mri-and-echocardiography
#1
Thomas Wehrum, Felix Guenther, Alexander Fuchs, Florian Schuchardt, Anja Hennemuth, Andreas Harloff
4D flow MRI is an emerging technique that allows quantification of 3D blood flow in vivo. However, comparisons with methods of blood velocity quantification used in clinical routine are sparse. Therefore, we compared velocity quantification using 4D flow MRI with transthoracic and transesophageal echocardiography at the mitral and aortic valves and the aorta. Forty-eight stroke patients (age 67.3 ± 15.0 years) were examined by 4D flow MRI. Blood flow velocities were assessed using standardized 2D analysis planes positioned in the mitral valve (MV), aortic valve (AV), ascending aorta (AAo), and descending aorta (DAo) and were compared with echocardiography...
January 11, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29324528/titanium-elastic-nailing-has-superior-value-to-plate-fixation-of-midshaft-femur-fractures-in-children-5-to-11-years
#2
Jerad D Allen, Kevin Murr, Ferras Albitar, Cale Jacobs, Eric S Moghadamian, Ryan Muchow
BACKGROUND: American Academy of Orthopaedic Surgeons (AAOS) Clinical Practice Guidelines for pediatric femoral shaft fractures indicate titanium elastic nails (TENs) for children 5 to 11 years old. Growing evidence suggests these fractures may also be treated with open or submuscular plating. The purpose of this study was to compare estimated blood loss (EBL), operative time, fluoroscopy time, cost, and subjective and objective pain scores between TENs and plating techniques used in 5- to 11-year-old children with midshaft femur fractures based on length stability...
January 10, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29324526/do-professional-society-advocacy-campaigns-have-an-impact-on-pediatric-orthopaedic-injuries
#3
Alexa J Karkenny, Denver A Burton, Kathleen J Maguire, Regina Hanstein, Norman Y Otsuka
PURPOSE: The American Academy of Orthopaedic Surgeons (AAOS) and the American Academy of Pediatrics (AAP) both advocate for childhood injury prevention by publishing recommendations to orthopaedic surgeons, pediatricians, and the public. Popular topics of advocacy campaigns have included trampolines, all-terrain vehicles (ATVs), and lawnmowers. The purpose of this study was to investigate the temporal relationship between AAOS/AAP advocacy and pediatric orthopaedic injury rates, using these topics as examples...
January 10, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29324447/characteristic-motor-and-nonmotor-symptoms-related-to-quality-of-life-in-drug-na%C3%A3-ve-patients-with-late-onset-parkinson-disease
#4
Hea Ree Park, Jinyoung Youn, Jin Whan Cho, Eung-Seok Oh, Ji Sun Kim, Suyeon Park, Wooyoung Jang, Jin Se Park
BACKGROUND/AIMS: Unlike young-onset Parkinson disease (YOPD), characteristics of late-onset PD (LOPD) have not yet been clearly elucidated. We investigated characteristic features and symptoms related to quality of life (QoL) in LOPD patients. METHODS: We recruited drug-naïve, early PD patients. The patient cohort was divided into 3 subgroups based on patient age at onset (AAO): the YOPD group (AAO <50 years), the middle-onset PD (MOPD) group, and the LOPD group (AAO ≥70 years)...
January 12, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29315223/enzymatic-preparation-of-2-5-furandicarboxylic-acid-fdca-a-substitute-of-terephthalic-acid-by-the-joined-action-of-three-fungal-enzymes
#5
Alexander Karich, Sebastian B Kleeberg, René Ullrich, Martin Hofrichter
Enzymatic oxidation of 5-hydroxymethylfurfural (HMF) and its oxidized derivatives was studied using three fungal enzymes: wild-type aryl alcohol oxidase (AAO) from three fungal species, wild-type peroxygenase from Agrocybe aegerita (AaeUPO), and recombinant galactose oxidase (GAO). The effect of pH on different reaction steps was evaluated and apparent kinetic data (Michaelis-Menten constants, turnover numbers, specific constants) were calculated for different enzyme-substrate ratios and enzyme combinations...
January 9, 2018: Microorganisms
https://www.readbyqxmd.com/read/29313046/an-in-situ-electron-donor-consumption-strategy-for-photoelectrochemical-biosensing-of-proteins-based-on-ternary-bi2s3-ag2s-tio2-nt-arrays
#6
Bing Wang, Jun-Tao Cao, Yu-Xiang Dong, Fu-Rao Liu, Xiao-Long Fu, Shu-Wei Ren, Shu-Hui Ma, Yan-Ming Liu
An ascorbic acid oxidase (AAO)-ascorbic acid bioevent-based electron donor consumption mode was introduced into the PEC bioassay for the first time. Ternary hybrid bismuth sulfide/silver sulfide/TiO2 nanotube arrays as the photoelectrode coupled with AAO attached to SiO2 as a dual signal quenching strategy were employed for sensitivity enhancement.
January 9, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29309683/congress-of-neurological-surgeons-systematic-review-and-evidence-based-guidelines-on-hearing-preservation-outcomes-in-patients-with-sporadic-vestibular-schwannomas
#7
Matthew L Carlson, Esther X Vivas, D Jay McCracken, Alex D Sweeney, Brian A Neff, Neil T Shepard, Jeffrey J Olson
Question 1: What is the overall probability of maintaining serviceable hearing following stereotactic radiosurgery utilizing modern dose planning, at 2, 5, and 10 yr following treatment? Recommendation: Level 3: Individuals who meet these criteria and are considering stereotactic radiosurgery should be counseled that there is moderately high probability (>50%-75%) of hearing preservation at 2 yr, moderately high probability (>50%-75%) of hearing preservation at 5 yr, and moderately low probability (>25%-50%) of hearing preservation at 10 yr...
December 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29290484/pulsed-wave-doppler-recordings-in-the-proximal-descending-aorta-in-patients-with-chronic-aortic-regurgitation-insights-from-cardiovascular-magnetic-resonance
#8
Odd Bech-Hanssen, Christian L Polte, Frida Svensson, Åse A Johnsson, Kerstin M Lagerstrand, Ulf Cederbom, Sinsia A Gao
BACKGROUND: The pulsed-wave Doppler recording in the descending aorta (PWDDAO) is one of the parameters used in grading aortic regurgitation (AR) severity. The aim of the present study was to investigate the assessment of chronic AR by PWDDAO with insights from cardiovascular magnetic resonance (CMR). METHODS: This prospective study comprised 40 patients investigated with echocardiography and CMR within 4 hours either prior to valve surgery (n = 23) or as part of their follow-up (n = 17) due to moderate or severe AR...
December 29, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29285950/prrt2-mutations-in-a-cohort-of-chinese-families-with-paroxysmal-kinesigenic-dyskinesia-and-genotype-phenotype-correlation-reanalysis-in-literatures
#9
Guohua Zhao, Xiaomin Liu, Qiong Zhang, Kang Wang
PURPOSE OF THE STUDY: Though rare, children are susceptible to paroxysmal dyskinesias (PxDs) such as paroxysmal kinesigenic dyskinesia (PKD), and infantile convulsions and choreoathetosis (ICCA, also termed PKD/IC). PKD is characterized by recurrent attacks of involuntary movements mostly starting around puberty, and PKD/IC also presents with clusters of non-febrile seizures at ages between 3 and 12 months in addition to symptoms of PKD. Recent studies showed that the cause of PKD or PKD/IC could be proline-rich transmembrane protein 2 (PRRT2) gene mutations...
December 29, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29283898/compliance-with-the-aaos-guidelines-for-treatment-of-osteoarthritis-of-the-knee-a-survey-of-the-american-association-of-hip-and-knee-surgeons
#10
Victor Rex Carlson, Alvin Chua Ong, Fabio Ramiro Orozco, Victor Hugo Hernandez, Rex William Lutz, Zachary Douglas Post
INTRODUCTION: The American Academy of Orthopaedic Surgeons (AAOS) published a series of evidence-based guidelines for treatment of knee osteoarthritis (OA). We studied compliance with these guidelines among orthopaedic surgeons. METHODS: We sent a survey to members of the American Association of Hip and Knee Surgeons. It included five clinical vignettes based on the Kellgren-Lawrence radiographic system for classification of knee OA. Respondents selected treatment currently supported or not supported by the AAOS guidelines...
December 22, 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29283556/nanochannels-photoelectrochemical-biosensor
#11
Nan Zhang, Yi-Fan Ruan, Li-Bin Zhang, Wei-Wei Zhao, Jing-Juan Xu, Hong-Yuan Chen
Nanochannels have brought new opportunities for biosensor development. Herein we present the novel concept of nanochannels photoelectrochemical (PEC) biosensor based on the integration of a unique CuxO nanopyramid islands (NPIs) photocathode, the anodic aluminum oxide (AAO) membrance, and the alkaline phosphatase (ALP) catalytic chemistry. The CuxO NPIs photocathode possessed good performance, and further assembly with AAO will yield the designed architecture composed of vertically-aligned, highly-ordered nanoarrays bottomed with CuxO NPIs film...
December 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29261108/activation-of-recombinantly-expressed-l-amino-acid-oxidase-from-rhizoctonia-solani-by-sodium-dodecyl-sulfate
#12
Katharina Hahn, Yvonne Hertle, Svenja Bloess, Tilman Kottke, Thomas Hellweg, Gabriele Fischer von Mollard
l-Amino acid oxidases (l-AAO) catalyze the oxidative deamination of l-amino acids to the corresponding α-keto acids. The non-covalently bound cofactor FAD is reoxidized by oxygen under formation of hydrogen peroxide. We expressed an active l-AAO from the fungus Rhizoctonia solani as a fusion protein in E. coli. Treatment with small amounts of the detergent sodium dodecyl sulfate (SDS) stimulated the activity of the enzyme strongly. Here, we investigated whether other detergents and amphiphilic molecules activate 9His-rsLAAO1...
December 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29260601/an-association-study-between-scfd1-rs10139154-variant-and-amyotrophic-lateral-sclerosis-in-a-chinese-cohort
#13
Yongping Chen, Qingqing Zhou, Xiaojing Gu, Qianqian Wei, Bei Cao, Hui Liu, Yanbing Hou, Huifang Shang
BACKGROUND: A recent genome-wide association study (GWAS) demonstrated that the Sec1 family domain containing 1 (SCFD1) gene is associated with amyotrophic lateral sclerosis (ALS). The objective of our study was to investigate the association between the single nucleotide polymorphism (SNP) rs10139154 in the SCFD1 gene and ALS in a Chinese cohort. METHODS: A cohort of 1074 sporadic ALS (SALS) patients from the Department of Neurology at the West China Hospital of Sichuan University were genotyped for rs10139154 using a polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis...
December 20, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29258760/adult-reconstruction-studies-presented-at-aaos-and-aahks-2011-2015-annual-meetings-is-there-a-difference-in-future%C3%A2-publication
#14
Qais Naziri, Patrick J Mixa, Daniel P Murray, Preston W Grieco, Emmanuel M Illical, Aditya V Maheshwari, Harpal S Khanuja
BACKGROUND: The purpose of this study was to compare adult reconstruction abstracts presented at the American Academy of Orthopaedic Surgeons (AAOS) and the American Association of Hip and Knee Surgeons (AAHKS) annual meetings. METHODS: A total of 1355 podium and 1731 poster presentations from the adult reconstruction sections of the AAOS and AAHKS meetings from 2011 to 2015 were reviewed for publication in peer-reviewed literature. Authors who were added or removed from the original abstract and the final manuscript were recorded...
December 6, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29251119/association-of-tnf-%C3%AE-rs1799964-and-il-1%C3%AE-rs16944-polymorphisms-with-multiple-system-atrophy-in-chinese-han-population
#15
Xin Zhou, Chunrong Wang, Zhao Chen, Yun Peng, Huirong Peng, Xuan Hou, Wei Ye, Rong Qiu, Kun Xia, Beisha Tang, Hong Jiang
BACKGROUND: Recent evidence suggested that several single nucleotide polymorphisms (SNPs) of inflammation-related genes (TNF-α rs1799964, IL-1α rs1800587, IL-1β rs16944, IL-8 rs4073, ICAM-1 rs5498) were associated with multiple system atrophy (MSA). Herein, we conducted this case-control study to evaluate the possible correlation between the five SNPs related to inflammatory and MSA in Chinese Han population. METHODS AND PATIENTS: We recruited 154 sporadic patients with MSA and 223 health controls in this study...
December 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29249939/co-expression-patterns-between-atn1-and-atxn2-coincide-with-brain-regions-affected-in-huntington-s-disease
#16
Arlin Keo, N Ahmad Aziz, Oleh Dzyubachyk, Jeroen van der Grond, Willeke M C van Roon-Mom, Boudewijn P F Lelieveldt, Marcel J T Reinders, Ahmed Mahfouz
Cytosine-adenine-guanine (CAG) repeat expansions in the coding regions of nine polyglutamine (polyQ) genes (HTT, ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, ATN1, AR, and TBP) are the cause of several neurodegenerative diseases including Huntington's disease (HD), six different spinocerebellar ataxias (SCAs), dentatorubral-pallidoluysian atrophy, and spinobulbar muscular atrophy. The expanded CAG repeat length in the causative gene is negatively related to the age-at-onset (AAO) of clinical symptoms. In addition to the expanded CAG repeat length in the causative gene, the normal CAG repeats in the other polyQ genes can affect the AAO, suggesting functional interactions between the polyQ genes...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29210440/microwave-annealing-induced-nanowetting-of-block-copolymers-in-cylindrical-nanopores
#17
Chun-Wei Chang, Ming-Hsiang Cheng, Hao-Wen Ko, Chien-Wei Chu, Yi-Hsuan Tu, Jiun-Tai Chen
Block copolymers have attracted great attention because of their abilities to self-assemble into well-ordered microphase-separated structures. To generate nanopatterns of block copolymers with long-range ordering and low-defect densities in shorter time scales, microwave annealing has recently been applied. Microwave annealing, however, has so far only been used for block copolymer bulks and thin films. In this work, we discover that microwave annealing can be successfully applied to three-dimensional block copolymer nanostructures by studying the infiltration and microphase separation of block copolymers in cylindrical nanopores upon microwave irradiation...
December 6, 2017: Soft Matter
https://www.readbyqxmd.com/read/29206322/4d-flow-mri-cardiac-function-and-t1-mapping-association-of-valve-mediated-changes-in-aortic-hemodynamics-with-left-ventricular-remodeling
#18
Julia Geiger, Amir A Rahsepar, Kenichiro Suwa, Alex Powell, Ahmadreza Ghasemiesfe, Alex J Barker, Jeremy D Collins, James C Carr, Michael Markl
BACKGROUND: Patients with bicuspid aortic valve (BAV) show altered hemodynamics in the ascending aorta that can be assessed by 4D flow MRI. PURPOSE: Comprehensive cardiac MRI was applied to test the hypothesis that BAV-mediated changes in aortic hemodynamics (wall shear stress [WSS] and velocity) are associated with parameters of left ventricular (LV) remodeling. STUDY TYPE: Retrospective data analysis. POPULATION: Forty-nine BAV patients (mean age = 50...
December 5, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29199756/a-ferroelectric-liquid-crystal-confined-in-cylindrical-nanopores-reversible-smectic-layer-buckling-enhanced-light-rotation-and-extremely-fast-electro-optically-active-goldstone-excitations
#19
Mark Busch, Andriy V Kityk, Wiktor Piecek, Tommy Hofmann, Dirk Wallacher, Sylwia Całus, Przemysław Kula, Martin Steinhart, Manfred Eich, Patrick Huber
The orientational and translational order of a thermotropic ferroelectric liquid crystal (2MBOCBC) imbibed in self-organized, parallel, cylindrical pores with radii of 10, 15, or 20 nm in anodic aluminium oxide monoliths (AAO) are explored by high-resolution linear and circular optical birefringence as well as neutron diffraction texture analysis. The results are compared to experiments on the bulk system. The native oxidic pore walls do not provide a stable smectogen wall anchoring. By contrast, a polymeric wall grafting enforcing planar molecular anchoring results in a thermal-history independent formation of smectic C* helices and a reversible chevron-like layer buckling...
December 4, 2017: Nanoscale
https://www.readbyqxmd.com/read/29194225/hearing-outcomes-after-stereotactic-radiosurgery-for-jugular-paraganglioma
#20
Neil S Patel, Michael J Link, Colin L W Driscoll, Bruce E Pollock, Christine M Lohse, Matthew L Carlson
OBJECTIVE: To describe audiometric outcomes following stereotactic radiosurgery (SRS) for jugular paraganglioma (JP). STUDY DESIGN: Retrospective review. SETTING: Tertiary referral center. PATIENTS: Patients with pretreatment serviceable hearing (American Academy of Otolaryngology-Head and Neck Surgery [AAO-HNS] Class A or B) and serial post-SRS audiometric follow-up who underwent Gamma Knife SRS for JP between 1990 and 2017...
November 30, 2017: Otology & Neurotology
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