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https://www.readbyqxmd.com/read/29054095/ginkgolide-b-and-bilobalide-ameliorate-neural-cell-apoptosis-in-%C3%AE-synuclein-aggregates
#1
Jun Hua, Nuo Yin, Beibei Yang, Ji Zhang, Jianhua Ding, Yi Fan, Gang Hu
The accumulation of aggregated forms of the α-Synuclein (α-Syn) is associated with the pathogenesis of Parkinson's disease (PD), a chronic progressive neurodegenerative disorder. Extensive evidences have shown the promising effects of Ginkgo biloba consumption on motor activity after PD. However, the mechanisms underline the α-Syn-induced cell damage and whether ginkgolides exert neuroprotection against this injury are unclear. Here we showed that aggregated recombinant human α-Syn, but not α-Syn monomers, triggered cell injury in cultured human neuroblastoma cell line SH-SY5Y in an apoptosis way by using flow cytometry and western blot assay...
October 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29054046/surface-modification-of-polyisobutylene-via-grafting-amino-acid-based-poly-acryloyl-6-aminocaproic-acid-as-multifunctional-material
#2
Yanqiu Du, Chunming Li, Jing Jin, Chao Li, Wei Jiang
Amino acid-based P(acryloyl-6-aminocaproic acid) (PAACA) brushes were fabricated on polyisobutylene (PIB) surface combined with plasma pre-treatment and UV-induced grafting polymerization to construct an antifouling and functional material. The hydrophilicity and hemocompatibility of PIB were largely improved by surface modification of AACA, which were confirmed by water contact angle and platelet adhesion, respectively. PAACA brushes were precisely located onto the surface of PIB to create a patterned PIB-g-PAACA structure, and then the carboxyl groups on PAACA was activated to immobilize functional protein-Concanavalin A (Con A)...
October 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29054041/cardiovascular-obstetric-and-neonatal-outcomes-in-women-with-previous-fontan-repair
#3
REVIEW
S J Bonner, O Asghar, A Roberts, S Vause, B Clarke, B Keavney
OBJECTIVES: To determine cardiovascular, obstetric and neonatal outcomes of pregnancies in women who have a Fontan circulation. METHODS: A retrospective case note review of all women with a Fontan circulation who attended the joint obstetric cardiac antenatal clinic at St Mary's Hospital, Manchester (UK) between 2004 and 2016 was performed. RESULTS: In total, there were 19 pregnancies in 9 women with a history of Fontan repair. 23 women with univentricular physiology attended in this time period...
October 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29053985/rapid-cultivation-of-free-living-planktonic-anammox-cells
#4
Lei Zhang, Satoshi Okabe
Despite that anaerobic ammonium oxidizing (anammox) bacteria are key players in the global nitrogen cycle, no pure cultures are still available. Planktonic cell culture with high purity is, therefore, essential for physiological and biochemical studies of anammox bacteria. However, development of such planktonic cell cultures requires an enormous amount of time and effort. Here we developed a novel rapid method for cultivating free-living planktonic anammox cells. First, anammox granules were physically dispersed, immobilized in 6% polyvinyl alcohol-4% sodium alginate (PVA-SA) gel beads, and then pre-cultured in an up-flow column reactor...
October 15, 2017: Water Research
https://www.readbyqxmd.com/read/29053943/inflammation-status-of-healthy-young-men-initial-and-specific-responses-to-resistance-training
#5
Johanna K Ihalainen, Heikki Peltonen, Göran Paulsen, Juha P Ahtiainen, Ritva S Taipale, Mari Hämäläinen, Eeva Moilanen, Antti A Mero
PURPOSE: Our primary aim was to study the effects of a 4 wk preparatory resistance training (RT) period followed by 12 wks of two specific RT protocols (either hypertrophic-strength, HS, or strength-hypertrophy-power, SHP, training) on inflammation markers and the possible relationship of the changes in abdominal fat and lean mass to the changes in inflammation status. METHODS: A total of 82 healthy men were included in the study. Maximal concentric leg press strength (1RM), total body lean mass, total body and abdominal fat mass, circulating high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra), monocyte chemoattractant protein 1 (MCP-1), and selected adipocytokines (resistin, adiponectin and leptin) concentrations were measured before (PRE) and after 4 (wk4) and 16 weeks (wk16) of RT...
October 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29053908/no-time-to-hesitate-in-acute-in-hospital-stroke
#6
EDITORIAL
Annette Fromm
The treatment options for acute ischemic stroke are rapidly improving, and there is high awareness for community-onset stroke, pre-hospital pathways and streamline in-hospital management. However, the management of in-hospital stroke is often less well established, and stringent procedures are frequently missing. Higher rates of in-hospital complications and in-hospital mortality were suggested among in-hospital stroke patients who had been treated with i.v. thrombolysis. This issue is addressed in a new propensity-matched analysis from the SITS-EAST registry...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053905/distinct-predictive-role-of-collateral-status-on-clinical-outcome-in-variant-stroke-subtypes-of-acute-large-arterial-occlusion
#7
Xuting Zhang, Meixia Zhang, Wenhong Ding, Shenqiang Yan, David S Liebeskind, Min Lou
BACKGROUND: Clinical trials have showed that robust collateral flow has a relationship with good clinical outcome, however, different stroke subtypes were lumped together. This study explored the relationship between baseline collaterals and the onset-to-imaging time (OIT), and the correlation between pre-treatment collateral status and clinical outcome among different subtypes. METHOD: We reviewed prospectively collected data from consecutive acute ischemic stroke (AIS) patients with acute middle cerebral artery occlusion who received reperfusion therapy...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053903/galectin-3-an-emerging-biomarker-in-stroke-and-cerebrovascular-diseases
#8
Anand Venkatraman, Shalaka Hardas, Nirav Patel, Navkaranbir Singh Bajaj, Garima Arora, Pankaj Arora
BACKGROUND: The carbohydrate-binding molecule Galectin-3 has garnered significant attention recently as a biomarker for various conditions ranging from cardiac disease to obesity. Though there have been several recent studies investigating its role in stroke and other cerebrovascular diseases, awareness of this emerging biomarker in the wider neurology community is limited. METHODS: We performed a systematic search in PubMed, EMBASE, Scopus, CINAHL, Clinicaltrials...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053889/optimization-of-mass-spectrometry-acquisition-parameters-for-determination-of-polycarbonate-additives-degradation-products-and-colorants-migrating-from-food-contact-materials-to-chocolate
#9
Chiara Bignardi, Antonella Cavazza, Carmen Laganà, Paola Salvadeo, Claudio Corradini
The interest towards the so-called "substances of emerging concerns", in particular referred to objects intended to come into contact with food is recently growing. Such substances can be found in traces in simulants and in food products put in contact with plastic materials. In this context, it is important to set up analytical systems characterized by high sensitivity, and to improve detection parameters to enhance signals. This work was aimed at optimizing a method based on UHPLC coupled to High Resolution Mass Spectrometry to quantify the most common plastic additives, and able to detect the presence of polymers degradation products and coloring agents migrating from plastic re-usable containers...
October 20, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29053883/pharmacokinetics-of-inorganic-cobalt-and-a-vitamin-b12-supplement-in-the-thoroughbred-horse-differentiating-cobalt-abuse-from-supplementation
#10
L L Hillyer, Z Ridd, S Fenwick, P Hincks, S W Paine
BACKGROUND: Whilst cobalt is an essential micronutrient for vitamin B12 synthesis in the horse, at supra-physiological concentrations it has been shown to enhance performance in humans and rats and there is evidence that its administration in high doses to horses poses a welfare threat. Animal sport regulators currently control cobalt abuse via international race day thresholds, but since cobalt may be present in physiological concentrations this work was initiated to explore means of potentially adding to application of those thresholds...
October 20, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29053882/electrodiagnostic-studies-in-the-intensive-care-unit-a-comparison-study-two-decades-later
#11
Ajitesh Ojha, Sasha A Zivkovic, David Lacomis
INTRODUCTION: Since the late 1980s, critical illness myopathy (CIM) and polyneuropathy (CIP) have been increasingly recognized in the intensive care unit (ICU). We explored whether these causes of ICU weakness were now more likely to lead to electrodiagnostic studies (EDX) at our institution than they were 19-20 years earlier. METHODS: We reviewed 100 consecutive ICU patients who underwent EDX from 2009-2015 and compared them to a previously reported study population from 1990-1995...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053802/docosahexaenoic-acid-supplementation-in-pregnancy-modulates-placental-cellular-signaling-and-nutrient-transport-capacity-in-obese-women
#12
Susanne Lager, Vanessa I Ramirez, Ometeotl Acosta, Christiane Meireles, Evelyn Miller, Francesca Gaccioli, Fredrick J Rosario, Jonathan A L Gelfond, Kevin Hakala, Susan T Weintraub, Debra A Krummel, Theresa L Powell
Context: Maternal obesity in pregnancy has profound impacts on maternal metabolism and promotes placental nutrient transport, which may contribute to fetal overgrowth in these pregnancies. The fatty acid docosahexaenoic acid (DHA) has bioactive properties that may improve outcomes in obese pregnant women by modulating placental function. Objective: To determine the effects of DHA supplementation in obese pregnant women on maternal metabolism and placental function...
October 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29053725/the-effects-of-training-with-loads-that-maximise-power-output-and-individualised-repetitions-vs-traditional-power-training
#13
J M Sarabia, M Moya-Ramón, J L Hernández-Davó, J Fernandez-Fernandez, R Sabido
BACKGROUND: It has been suggested that strength training effects (i.e. neural or structural) vary, depending on the total repetitions performed and velocity loss in each training set. PURPOSE: The aim of this study is to compare the effects of two training programmes (i.e. one with loads that maximise power output and individualised repetitions, and the other following traditional power training). METHODS: Twenty-five males were divided into three groups (optimum power [OP = 10], traditional training [TT = 9] and control group [CG = 6])...
2017: PloS One
https://www.readbyqxmd.com/read/29053700/come-to-the-light-side-in-vivo-monitoring-of-pseudomonas-aeruginosa-biofilm-infections-in-chronic-wounds-in-a-diabetic-hairless-murine-model
#14
Alessandra M Agostinho Hunt, Jacob A Gibson, Casandra L Larrivee, Sandra O'Reilly, Svetlana Navitskaya, Julia V Busik, Christopher M Waters
The presence of bacteria as structured biofilms in chronic wounds, especially in diabetic patients, is thought to prevent wound healing and resolution. Chronic mouse wounds models have been used to understand the underlying interactions between the microorganisms and the host. The models developed to date rely on the use of haired animals and terminal collection of wound tissue for determination of viable bacteria. While significant insight has been gained with these models, this experimental procedure requires a large number of animals and sampling is time consuming...
October 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053699/evaluation-of-synapse-density-in-hippocampal-rodent-brain-slices
#15
Faye McLeod, Aude Marzo, Marina Podpolny, Soledad Galli, Patricia Salinas
In the brain, synapses are specialized junctions between neurons, determining the strength and spread of neuronal signaling. The number of synapses is tightly regulated during development and neuronal maturation. Importantly, deficits in synapse number can lead to cognitive dysfunction. Therefore, the evaluation of synapse number is an integral part of neurobiology. However, as synapses are small and highly compact in the intact brain, the assessment of absolute number is challenging. This protocol describes a method to easily identify and evaluate synapses in hippocampal rodent slices using immunofluorescence microscopy...
October 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053697/stereotactically-guided-ablation-of-the-rat-auditory-cortex-and-localization-of-the-lesion-in-the-brain
#16
Verónica Lamas, Sheila Estévez, Marianni Pernía, Ignacio Plaza, Miguel A Merchán
The rat auditory cortex (AC) is becoming popular among auditory neuroscience investigators who are interested in experience-dependence plasticity, auditory perceptual processes, and cortical control of sound processing in the subcortical auditory nuclei. To address new challenges, a procedure to accurately locate and surgically expose the auditory cortex would expedite this research effort. Stereotactic neurosurgery is routinely used in pre-clinical research in animal models to engraft a needle or electrode at a pre-defined location within the auditory cortex...
October 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053696/3-end-sequencing-library-preparation-with-a-seq2
#17
Georges Martin, Ralf Schmidt, Andreas J Gruber, Souvik Ghosh, Walter Keller, Mihaela Zavolan
Studies in the last decade have revealed a complex and dynamic variety of pre-mRNA cleavage and polyadenylation reactions. mRNAs with long 3' untranslated regions (UTRs) are generated in differentiated cells whereas proliferating cells preferentially express transcripts with short 3'UTRs. We describe the A-seq protocol, now at its second version, which was developed to map polyadenylation sites genome-wide and study the regulation of pre-mRNA 3' end processing. Also this current protocol takes advantage of the polyadenylate (poly(A)) tails that are added during the biogenesis of most mammalian mRNAs to enrich for fully processed mRNAs...
October 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053693/in-vivo-tracking-of-human-adipose-derived-mesenchymal-stem-cells-in-a-rat-knee-osteoarthritis-model-with-fluorescent-lipophilic-membrane-dye
#18
Meng Li, Ming Hao, Dong Jiang, Yanxi Chen, Wen Wang
In order to support the clinical application of human adipose-derived mesenchymal stem cell (haMSC) therapy for knee osteoarthritis (KOA), we examined the efficacy of cell persistence and biodistribution of haMSCs in animal models. We demonstrated a method to label the cell membrane of haMSCs with lipophilic fluorescent dye. Subsequently, intra-articular injection of the labeled cells in rats with surgically induced KOA was monitored dynamically by an in vivo imaging system. We employed the lipophilic carbocyanines DiD (DilC18 (5)), a far-red fluorescent Dil (dialkylcarbocyanines) analog, which utilized a red laser to avoid excitation of the natural green autofluorescence from surrounding tissues...
October 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053691/quantitative-whole-mount-immunofluorescence-analysis-of-cardiac-progenitor-populations-in-mouse-embryos
#19
Evan Bardot, Nikos Tzavaras, Deanna L Benson, Nicole C Dubois
The use of ever-advancing imaging techniques has contributed broadly to our increased understanding of embryonic development. Pre-implantation development and organogenesis are two areas of research that have benefitted greatly from these advances, due to the high quality of data that can be obtained directly from imaging pre-implantation embryos or ex vivo organs. While pre-implantation embryos have yielded data with especially high spatial resolution, later stages have been less amenable to three-dimensional reconstruction...
October 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053672/sample-extraction-and-simultaneous-chromatographic-quantitation-of-doxorubicin-and-mitomycin-c-following-drug-combination-delivery-in-nanoparticles-to-tumor-bearing-mice
#20
Rui Xue Zhang, Tian Zhang, King Chen, Ji Cheng, Paris Lai, Andrew M Rauth, K Sandy Pang, Xiao Yu Wu
Combination chemotherapy is frequently used in the clinic for cancer treatment; however, associated adverse effects to normal tissue may limit its therapeutic benefit. Nanoparticle-based drug combination has been shown to mitigate the problems encountered by free drug combination therapy. Our previous studies have shown that the combination of two anticancer drugs, doxorubicin (DOX) and mitomycin C (MMC), produced a synergistic effect against both murine and human breast cancer cells in vitro. DOX and MMC co-loaded polymer-lipid hybrid nanoparticles (DMPLN) bypassed various efflux transporter pumps that confer multidrug resistance and demonstrated enhanced efficacy in breast tumor models...
October 5, 2017: Journal of Visualized Experiments: JoVE
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