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https://www.readbyqxmd.com/read/29454292/the-nursification-of-a-bioscience-unit-and-its-impact-on-student-satisfaction-and-learning-in-an-undergraduate-nursing-degree
#1
Sheila Mortimer-Jones, Catherine Fetherston
Undergraduate nursing students traditionally find bioscience difficult, which can be compounded by an inability to relate bioscience theory to nursing practice. Subsequently, many registered nurses feel they lack knowledge in this area. Several studies have identified this problem and focused on the importance of linking bioscience theory in undergraduate nursing curricula to clinical practice. The aim of this study was to assess whether nursification (the active association of a subject with nursing theory and practice) of the bioscience content of a first year, first semester unit impacts on the students' learning experience...
February 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29454286/the-vasodilatory-effect-of-allopurinol-mediates-its-antihypertensive-effect-effects-on-calcium-movement-and-cardiac-hemodynamics
#2
Hany M El-Bassossy, Mona F Mahmoud, Basma G Eid
Despite the reported reduction in blood pressure in hypertensive patients treated with allopurinol, the mechanism of the allopurinol hypotensive effect is still unclear. In the current study, the hypotensive effect of allopurinol has been fully investigated in hypertensive rats. Hypertension was induced in rats by angiotensin II (120 ng/min/kg) infusion for two weeks. Rats were then subjected to real-time recording of blood pressure, left ventricular pressure and volume and surface ECG. After 10 min of basal recording, allopurinol was slowly injected into the femoral vein with a dose of 10 μmole/kg...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29454279/bonding-of-composite-cements-to-zirconia-a-systematic-review-and-meta-analysis-of-in-vitro-studies
#3
REVIEW
Putsadeeporn Thammajaruk, Masanao Inokoshi, Shanley Chong, Massimiliano Guazzato
OBJECTIVES: The aim of this study was to systematically review the literature and statistically analyze bond strength data to identify the influence that composite cements, type of test methodology, chemical and mechanical pre-treatments have on the bond strength of composite cements to zirconia in three different artificial aging conditions. METHODS: The literature was electronically searched in MEDLINE, PUBMED, EMBASE, and SCOPUS to select relevant articles that evaluated the bond strength between zirconia and composite cements...
February 8, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29454176/efficacy-of-intensive-voice-feminisation-therapy-in-a-transgender-young-offender
#4
Sterling Quinn, Nathaniel Swain
Research suggests that transgender young offenders are a uniquely vulnerable caseload that may benefit from speech pathology intervention to help bring their voice into alignment with their gender identity. However, no previous studies have investigated treatment efficacy in this population. This study investigated the impact of intensive voice feminisation therapy targeting fundamental frequency and oral resonance in a 17 year old transgender individual within a youth justice institution. Acoustic analysis, listener and self-ratings of vocal femininity, self-ratings of vocal satisfaction, a post-treatment structured interview, and pre- and post- treatment completion of the Transsexual Voice Questionnaire (TVQ MtF ) were utilised to determine treatment impact...
February 8, 2018: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29454158/polyisocyanopeptide-hydrogels-a-novel-thermo-responsive-hydrogel-supporting-pre-vascularization-and-the-development-of-organotypic-structures
#5
Jakub Zimoch, Joan Simó Padial, Agnes S Klar, Queralt Vallmajo-Martin, Martin Meuli, Thomas Biedermann, Christopher J Wilson, Alan Rowan, Ernst Reichmann
Molecular and mechanical interactions with the 3D extracellular matrix are essential for cell functions such as survival, proliferation, migration, and differentiation. Thermo-responsive biomimetic polyisocyanopeptide (PIC) hydrogels are promising new candidates for 3D cell, tissue, and organ cultures. This is a synthetic, thermo-responsive and stress-stiffening material synthesized via polymerization of the corresponding monomers using a nickel perchlorate as a catalyst. It can be tailored to meet various demands of cells by modulating its stiffness and through the decoration of the polymer with short GRGDS peptides using copper free click chemistry...
February 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29454147/factors-associated-with-malignancy-in-hysteroscopically-resected-endometrial-polyps-a-systematic-review-and-meta-analysis
#6
Lizandra M Paravidine Sasaki, Keitty R C Andrade, Ana Claudia Morais Godoy Figueiredo, Miriam da S Wanderley, Maurício G Pereira
The objective of our study was to estimate the frequency of pre-malignant and malignant lesions in endometrial polyps and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of pre-malignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible...
February 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29454133/prevalence-and-risk-factors-for-neural-axis-anomalies-in-idiopathic-scoliosis-a-systematic-review
#7
REVIEW
Johan L Heemskerk, Moyo C Kruyt, Dino Colo, René M Castelein, Diederik H R Kempen
BACKGROUND: There is ongoing controversy about the routine use of magnetic resonance imaging (MRI) preoperatively in patients with presumed idiopathic scoliosis (IS). Routine MRI can help identify possible causes for the deformity and detect anomalies which could complicate deformity surgery. However, routine MRI increases health care costs significantly and may reveal mild variations from normal without clinical relevance, that can still lead to anxiety and influence decision making...
February 14, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29454130/abscess-within-a-glioblastoma-mimicking-a-matryoshka-doll
#8
Kislay Kishore, Manish Beniwal, Shilpa Rao, K V L N Rao, Vikas Vazhayil, Dwarkanath Srinivas, Sampath Somanna
BACKGROUND: Abscess co-existing within a brain tumor is a rare entity. Case reports in literature primarily consist of sellar pathology and parenchymal lesions including meningioma, glioma, and metastases. We report a case of glioblastoma with an intra-tumoral abscess in a middle-aged lady with no prior invasive procedure or systemic focus of infection. CASE DESCRIPTION: A 45-year old lady presented with new onset generalized seizures and rapidly progressive left hemiparesis...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454128/preoperative-3-dimensional-angiography-data-and-intraoperative-real-time-vascular-data-integrated-in-microscope-based-navigation-by-automatic-patient-registration-applying-intraoperative-computed-tomography
#9
Barbara Carl, Miriam Bopp, Somar Chehab, Siegfried Bien, Christopher Nimsky
OBJECTIVE: To establish a workflow integrating preoperative 3-D angiography data, as well as intraoperative real-time vascular information in microscope-based navigation for aneurysm and arteriovenous malformation surgery. PATIENTS & METHODS: In 7 patients (3 arteriovenous malformations, 4 aneurysms) preoperative 3-D rotational angiography or computed tomography (CT) or magnetic resonance angiography data were navigated applying a 32-slice movable CT scanner for low-dose registration scanning...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454126/iatrogenic-spondylolisthesis-following-open-lumbar-laminectomy-case-series-and-review-of-the-literature
#10
Seba Ramhmdani, Yuanxuan Xia, Risheng Xu, Thomas Kosztowski, Daniel Sciubba, Timothy Witham, Ali Bydon
OBJECTIVE: The diagnosis and surgical management of post-laminectomy spondylolisthesis in patients without pre-operative instability is presented with a review of relevant literature. METHODS: We reviewed the medical records and radiographic studies of 105 patients who underwent first-time bilateral 1-4 level open laminectomies for degenerative lumbar disease at a single academic institution. Patients who initially presented with listhesis and had additional discectomy or fusion procedures were excluded...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454124/brainstem-dose-constraints-in-non-isometric-radiosurgical-treatment-planning-of-trigeminal-neuralgia-a-single-institution-experience
#11
Michael Zhang, Layton A Lamsam, Matthew K Schoen, Swapnil S Mehta, Geoffrey Appelboom, John K Adler, Scott G Soltys, Steven D Chang
INTRODUCTION: CyberKnife stereotactic radiosurgery (SRS) for trigeminal neuralgia (TGN) administers non-isometric, conformational high-dose radiation to the trigeminal nerve with risk of subsequent hypoesthesia. METHODS: We performed a retrospective, single-institution review of 66 TGN patients, treated by CyberKnife, to compare outcomes from two distinct treatment periods (standard dosing, N = 38 and reduced dosing, N = 28). Standard and reduced dosing permitted a maximum brainstem dose of 45 Gy and 25 Gy, respectively, each with a prescription dose of 60 Gy...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454100/patient-centered-outcomes-after-laparoscopic-paraesophageal-hernia-repair
#12
Tyler Hall, Natalie Warnes, Kristine Kuchta, Stephanie Novak, Herbert Hedberg, John G Linn, Stephen Haggerty, Woody Denham, Raymond J Joehl, Michael Ujiki
BACKGROUND: The aim of this study is to investigate patient centered quality of life (QOL) outcomes in patients undergoing laparoscopic paraesophageal hernia repair (LPEHR). STUDY DESIGN: We prospectively followed patients who underwent laparoscopic paraesophageal hernia repair between 2009 - 2016. QOL outcomes were measured using Short Form-36 (SF-36), GERD-HRQL, Reflux Symptom Index, and Dysphagia score surveys administered pre-operatively and at 3 weeks, 6 months, 1 year, and 2 years post- operatively...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29454098/quantitative-imaging-features-and-postoperative-hepatic-insufficiency-a-multi-institutional-expanded-cohort
#13
Linda M Pak, Jayasree Chakraborty, Mithat Gonen, William C Chapman, Richard Kg Do, Bas Groot Koerkamp, Kees Verhoef, Ser Yee Lee, Marco Massani, Eric P van der Stok, Amber L Simpson
BACKGROUND: Post-hepatectomy liver insufficiency (PHLI) is a significant cause of morbidity and mortality after liver resection. Quantitative imaging analysis using CT scans measures variations in pixel intensity related to perfusion. A preliminary study demonstrated a correlation between quantitative imaging features of the future liver remnant (FLR) parenchyma from preoperative CT scans and PHLI. The objective of the present study was to explore the potential application of quantitative imaging analysis in PHLI in an expanded, multi-institutional cohort...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29454079/a-novel-metric-that-quantifies-risk-stratification-for-evaluating-diagnostic-tests-the-example-of-evaluating-cervical-cancer-screening-tests-across-populations
#14
Hormuzd A Katki, Mark Schiffman
Our work involves assessing whether new biomarkers might be useful for cervical-cancer screening across populations with different disease prevalences and biomarker distributions. When comparing across populations, we show that standard diagnostic accuracy statistics (predictive values, risk-differences, Youden's index and Area Under the Curve (AUC)) can easily be misinterpreted. We introduce an intuitively simple statistic for a 2 × 2 table, Mean Risk Stratification (MRS): the average change in risk (pre-test vs...
February 14, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29454074/nutraceuticals-as-therapeutic-agents-for-atherosclerosis
#15
REVIEW
Joe W E Moss, Jessica O Williams, Dipak P Ramji
Atherosclerosis, a chronic inflammatory disorder of medium and large arteries and an underlying cause of cardiovascular disease (CVD), is responsible for a third of all global deaths. Current treatments for CVD, such as optimized statin therapy, are associated with considerable residual risk and several side effects in some patients. The outcome of research on the identification of alternative pharmaceutical agents for the treatment of CVD has been relatively disappointing with many promising leads failing at the clinical level...
February 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29454038/dendritic-cells-as-cancer-therapeutics
#16
REVIEW
Christian E Bryant, Sarah Sutherland, Benjamin Kong, Michael S Papadimitrious, Derek N J Hart
The ability of immune therapies to control cancer has recently generated intense interest. This therapeutic outcome is reliant on T cell recognition of tumour cells. The natural function of dendritic cells (DC) is to generate adaptive responses, by presenting antigen to T cells, hence they are a logical target to generate specific anti-tumour immunity. Our understanding of the biology of DC is expanding, and they are now known to be a family of related subsets with variable features and function. Most clinical experience to date with DC vaccination has been using monocyte-derived DC vaccines...
February 14, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29454037/melatonin-attenuates-%C3%AE-9-tetrahydrocannabinol-induced-reduction-in-rat-sperm-motility-and-kinematics-in-vitro
#17
Isiaka Abdullateef Alagbonsi, Luqman Aribidesi Olayaki
The use of Cannabis sativa (CS) has been widely demonstrated to have detrimental effect on male reproductive functions. Despite the well-known existence of endocannabinoid and melatonergic systems in semen, the physiological significance of their interaction is not understood. We recently showed that melatonin exacerbates the CS-induced gonadotoxicity in-vivo. To overcome the limitations associated with our in-vivo studies and further understand the role of cannabinoid-melatonin relationship in sperm functions, this study investigated the in-vitro effect of tetrahydrocannabinol (THC) and/or melatonin on motility and kinematics of capacitating rat sperms...
February 14, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29453979/toward-a-meaningful-definition-of-recovery-after-hip-fracture-comparing-two-definitions-for-community-dwelling-older-adults
#18
Mohammad Auais, Suzanne N Morin, Lois Finch, Sara Ahmed, Nancy Mayo
OBJECTIVES: To examine the course of recovery and resulting health-related quality of life (HRQL) after low-trauma hip fracture using two different definitions of recovery. DESIGN: Inception cohort with eight assessments over one year. SETTING: Participants were recruited from a tertiary-care hospital and followed in the community. INTERVENTION: Not applicable PARTICIPANTS: 47 (75% of all eligible) community-dwelling hip fracture patients (≥65 years)...
February 14, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29453978/venlafaxine-prevents-morphine-antinociceptive-tolerance-the-role-of-neuroinflammation-and-the-l-arginine-nitric-oxide-pathway
#19
Mohammad Taghi Mansouri, Bahareh Naghizadeh, Behnam Ghorbanzadeh, Soheila Alboghobeish, Neda Amirgholami, Gholamreza Houshmand, Omar Cauli
Opioid-induced neuroinflammation and the nitric oxide (NO) signal-transduction pathway are involved in the development of opioid analgesic tolerance. The antidepressant venlafaxine (VLF) modulates NO in nervous tissues, and so we investigated its effect on induced tolerance to morphine, neuroinflammation, and oxidative stress in mice. Tolerance to the analgesic effects of morphine were induced by injecting mice with morphine (50 mg/kg) once a day for three consecutive days; the effect of co-administration of VLF (5 or 40 mg/kg) with morphine was similarly tested in a separate group...
February 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29453931/comparison-of-return-to-pre-injury-sport-after-10-mm-size-bone-patellar-tendon-bone-bptb-versus-8-mm-hamstring-anterior-cruciate-ligament-reconstruction-a-retrospective-study-with-a-two-year-follow-up
#20
Rimtautas Gudas, Rokas Jurkonis, Alfredas Smailys
BACKGROUND The aim of this study was to evaluate the reconstruction of a torn anterior cruciate ligament (ACL) with 10 mm diameter BPTB (bone-patellar tendon-bone) autograft versus 8 mm HT (hamstring tendon) autografts, to compare the ability to restore pre-injury sports activities and reduce revision risk after these procedures. MATERIAL AND METHODS A prospective clinical review was performed to compare results of patients who underwent primary anatomical ACLR with 10 mm BPTB autografts with patients who underwent 8 mm diameter HT autografts, between January 2011 and January 2014...
February 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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