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https://www.readbyqxmd.com/read/29224237/major-haemorrhage-fatalities-in-the-australian-national-coronial-database
#1
Jacob S Gipson, Erica M Wood, Merrole F Cole-Sinclair, Zoe McQuilten, Neil Waters, Noel W Woodford
OBJECTIVE: The aim of the study is to describe the epidemiology of major bleeding fatalities. METHODS: A case series analysis of Australia's National Coronial Information System was conducted. Keywords were used to search for closed cases of major haemorrhage in the state of Victoria for the period 1 January 2009 to 31 December 2011. Coroners' findings, autopsy reports and police reports of cases were reviewed. Demographic data were extracted, and cases were assigned to a clinical bleeding context...
December 10, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29224234/an-observational-study-of-benzodiazepine-prescription-during-inpatient-alcohol-detoxification-for-patients-with-versus-without-chronic-pretreatment-with-high-dosage-baclofen
#2
Laura Martinez, Florence Vorspan, Xavier Declèves, Julien Azuar, Maeva Fortias, Franck Questel, Alexandra Dereux, Leslie Grichy, Hélène Barreteau, Frank Bellivier, Jean-Pierre Lépine, Vanessa Bloch
High dose baclofen is prescribed as a maintenance treatment to reduce alcohol use in patients with alcohol use disorder. Nevertheless, some patients still have massive alcohol intakes and require inpatient alcohol withdrawal. AIM: to compare the oral dose of benzodiazepine prescribed to manage alcohol withdrawal symptoms in patients with versus without steady state pre-treatment with high dose baclofen. METHODS: Retrospective chart review study. Prescribed benzodiazepine dose expressed in diazepam-equivalent was compared between groups...
December 10, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29224197/collecting-patient-reported-outcome-measures
#3
Susannah Ahern, Rasa Ruseckaite, Ilana N Ackerman
Patient-reported outcome measures (PROM) are potentially useful outcome measures that may be reported at the individual clinical, health service and/or health system level. PROM require clearly defined patient populations to enable comparisons, and are most meaningful when integrated with clinical data sets. Where possible PROM should be measured pre- and post-intervention using reliable and validated tools. A variety of PROM collection methods exist which each have strengths and limitations, with selection depending on their purpose and patient factors...
December 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29224188/an-evaluation-of-a-social-skills-intervention-for-adults-with-autism-spectrum-disorder-and-intellectual-disabilities-preparing-for-employment-in-ireland-a-pilot-study
#4
Edith Walsh, Jennifer Holloway, Helena Lydon
Individuals with autism spectrum disorder (ASD) are faced with significant barriers relating to employment opportunities and workplace participation. This study evaluated the effectiveness of the Walker social skills curriculum: the ACCESS program and video modeling to increase social communication skills necessary for workplace inclusion. Participants attended two sessions (i.e., 3 h) per week across a period of 20 weeks. A multiple-probe design was used to demonstrate social skills outcomes across three broad curricular areas (i...
December 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29224182/stable-and-rigid-dtpa-like-paramagnetic-tags-suitable-for-in-vitro-and-in-situ-protein-nmr-analysis
#5
Jia-Liang Chen, Yu Zhao, Yan-Jun Gong, Bin-Bin Pan, Xiao Wang, Xun-Cheng Su
Organic synthesis of a ligand with high binding affinities for paramagnetic lanthanide ions is an effective way of generating paramagnetic effects on proteins. These paramagnetic effects manifested in high-resolution NMR spectroscopy are valuable dynamic and structural restraints of proteins and protein-ligand complexes. A paramagnetic tag generally contains a metal chelating moiety and a reactive group for protein modification. Herein we report two new DTPA-like tags, 4PS-PyDTTA and 4PS-6M-PyDTTA that can be site-specifically attached to a protein with a stable thioether bond...
December 9, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/29224167/dna-methylation-analysis-of-free-circulating-dna-in-body-fluids
#6
Maria Jung, Glen Kristiansen, Dimo Dietrich
Circulating cell-free DNA in body fluids is an analyte of great interest in basic and clinical research. The analyses of DNA methylation and hydroxymethylation patterns in body fluids might allow one to determine the certain state of a disease, in particular of cancer. DNA methylation biomarkers in liquid biopsies, i.e. blood plasma samples, may help optimizing personalized therapy for individual patients. DNA methylation analyses of specific loci usually require a bisulfite conversion of the DNA, which requires a sufficiently high amount of DNA at the appropriate concentration...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29224085/aphasia-and-cognitive-impairment-decrease-the-reliability-of-rntms-language-mapping
#7
Vera Schwarzer, Ina Bährend, Tizian Rosenstock, Felix R Dreyer, Peter Vajkoczy, Thomas Picht
BACKGROUND: Navigated transcranial magnetic stimulation (nTMS) is a non-invasive mapping tool to locate functional areas of the brain. While gaining importance in the preoperative planning process in motor eloquent regions, its usefulness for reliably identifying language areas is still being discussed. The aim of this study was to identify biometric factors which might influence and therefore bias the results of repetitive nTMS (rnTMS) over cortex areas relevant for language. METHOD: We included data of 101 patients with language eloquent brain lesions who underwent preoperative rnTMS examination bihemispherically...
December 9, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29224070/genome-wide-analysis-of-dna-methylation-in-single-cells-using-a-post-bisulfite-adapter-tagging-approach
#8
Heather J Lee, Sébastien A Smallwood
DNA methylation is an epigenetic mark implicated in the regulation of key biological processes. Using high-throughput sequencing technologies and bisulfite-based approaches, it is possible to obtain comprehensive genome-wide maps of the mammalian DNA methylation landscape with a single-nucleotide resolution and absolute quantification. However, these methods were only applicable to bulk populations of cells. Here, we present a protocol to perform whole-genome bisulfite sequencing on single cells (scBS-Seq) using a post-bisulfite adapter tagging approach...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29224055/peri-operative-antibiotic-treatment-of-bacteriuria-reduces-early-deep-surgical-site-infections-in-geriatric-patients-with-proximal-femur-fracture
#9
Ronny Langenhan, Stefanie Bushuven, Niklas Reimers, Axel Probst
PURPOSE: The aim of this study was to conduct a re-evaluation of current strategies for peri-operative prophylaxis of infections in orthopaedic surgery of geriatric patients (≥65 years) with proximal femoral fractures (PFF). METHODS: Between 01/2010 and 08/2014 all post-operative infections after stabilization of PFF of 1,089 geriatric patients were recorded retrospectively. All patients pre-operatively received a single dose of 1.5 g cefuroxime (group 1). These were compared to prospectively determined post-operative rates of surgical site infection (SSI) of 441 geriatric patients, which were operated on between 09/2014 and 03/2017 due to PFF...
December 9, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29224013/response-of-renal-podocytes-to-excessive-hydrostatic-pressure-a-pathophysiologic-cascade-in-a-malignant-hypertension-model
#10
Ramzia Abu Hamad, Sylvia Berman, Yafit Hachmo, Moshe Stark, Fadia Hasan, Keren Doenyas-Barak, Shai Efrati
BACKGROUND/AIMS: Renal injuries induced by increased intra-glomerular pressure coincide with podocyte detachment from the glomerular basement membrane (GBM). In previous studies, it was demonstrated that mesangial cells have a crucial role in the pathogenesis of malignant hypertension. However, the exact pathophysiological cascade responsible for podocyte detachment and its relationship with mesangial cells has not been fully elucidated yet and this was the aim of the current study. METHODS: Rat renal mesangial or podocytes were exposed to high hydrostatic pressure in an in-vitro model of malignant hypertension...
December 7, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29223999/two-years-follow-up-of-patients-with-abnormal-uterine-bleeding-after-insertion-of-the-levonorgestrel-releasing-intrauterine-system
#11
Numan Cim, Sunullah Soysal, Sena Sayan, Begum Yildizhan, Erbil Karaman, Orkun Cetin, Harun Egemen Tolunay, Recep Yildizhan
AIM: To evaluate the efficacy and safety of levonorgestrel-releasing intrauterine system (LNG-IUS) in the long-term treatment of heavy menstrual blood loss in women unrelated to intrauterine pathology. METHODS: One hundred and six parous women aged 33-48 years with recurrent heavy menstrual bleeding (HMB) participated in this study. The women were followed up for 24 months and were assessed for intensity of bleeding both for pre- and post-insertion periods. An LNG-IUS was inserted in each patient within 7 days of the start of menstrual flow...
December 8, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29223904/spatiotemporal-variations-of-hydrogeochemistry-and-its-controlling-factors-in-the-gandaki-river-basin-central-himalaya-nepal
#12
Ramesh Raj Pant, Fan Zhang, Faizan Ur Rehman, Guanxing Wang, Ming Ye, Chen Zeng, Handuo Tang
The characterization and assessment of water quality in the head water region of Himalaya is necessary, given the immense importance of this region in sustaining livelihoods of people and maintaining ecological balance. A total of 165 water samples were collected from 55 sites during pre-monsoon, monsoon and post-monsoon seasons in 2016 from the Gandaki River Basin of the Central Himalaya, Nepal. The pH, EC values and TDS concentrations were measured in-situ and the concentrations of major ions (Ca2+, Mg2+, K+, Na+, Cl-, SO42-, NO3-) and Si were analyzed in laboratory...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223842/interstage-evaluation-of-homograft-valved-right-ventricle-to-pulmonary-artery-conduits-for-palliation-of-hypoplastic-left-heart-syndrome
#13
Nefthi Sandeep, Rajesh Punn, Sowmya Balasubramanian, Shea N Smith, Olaf Reinhartz, Yulin Zhang, Gail E Wright, Lynn F Peng, Lisa Wise-Faberowski, Frank L Hanley, Doff B McElhinney
OBJECTIVE: Palliation of hypoplastic left heart syndrome with a standard nonvalved right ventricle to pulmonary artery conduit results in an inefficient circulation in part due to diastolic regurgitation. A composite right ventricle pulmonary artery conduit with a homograft valve has a hypothetical advantage of reducing regurgitation, but may differ in the propensity for stenosis because of valve remodeling. METHODS: This retrospective cohort study included 130 patients with hypoplastic left heart syndrome who underwent a modified stage 1 procedure with a right ventricle to pulmonary artery conduit from 2002 to 2015...
November 8, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29223777/child-care-centre-adherence-to-infant-physical-activity-and-screen-time-recommendations-in-australia-canada-and-the-united-states-an-observational-study
#14
Lyndel Hewitt, Sara E Benjamin-Neelon, Valerie Carson, Rebecca M Stanley, Ian Janssen, Anthony D Okely
OBJECTIVE: The aim of this study was to compare adherence to physical activity and sedentary behaviour recommendations within the 2011 Institute of Medicine Early Childhood Obesity Prevention Policies as well as screen time recommendations from the 2013 American Academy of Pediatrics for samples of infants in child care centres in Australia, Canada, and the United States (US). METHODS: This cross-sectional study used data from: the Australian 2013 Standing Preschools (N=9) and the 2014-2017 Early Start Baseline (N=22) studies; the 2011 Canadian Healthy Living Habits in Pre-School Children study (N=14); and the American 2008 (N=31) and 2013-2017 (N=31) Baby Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) trials...
December 7, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/29223775/association-between-prenatal-bisphenol-a-and-phthalate-exposures-and-fetal-metabolic-related-biomarkers-the-hokkaido-study-on-environment-and-children-s-health
#15
Machiko Minatoya, Atsuko Araki, Chihiro Miyashita, Yu Ait Bamai, Sachiko Itoh, Jun Yamamoto, Yu Onoda, Kazuki Ogasawara, Toru Matsumura, Reiko Kishi
Bisphenol A and phthalates are widely detected in human urine, blood, breast milk, and amniotic fluid. Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics. Exposure to these chemicals during fetal development, and its consequences should be concerning because they can cross the placenta. Thus, this study aimed to assess the association between prenatal exposure to bisphenol A and phthalates, and cord blood metabolic-related biomarkers. Maternal serum was used during the first trimester, to determine prenatal exposure to bisphenol A and phthalates...
December 7, 2017: Environmental Research
https://www.readbyqxmd.com/read/29223750/choosing-pre-conception-planning-for-women-families-counselling-and-informed-consent-part-2-pre-conception-reproductive-planning-lifestyle-immunization-and-psychosocial-issues
#16
REVIEW
R Douglas Wilson
OBJECTIVE: To inform reproductive and other health care providers about pre-conception evaluation, including considerations for reproductive planning, lifestyle modification, immunization status and attitudes, and psychosocial issues. OPTIONS: This counselling information can be used for patient education and planning and possible pre-conception and/or prenatal testing. OUTCOMES: This information may allow for improved risk assessment when pre-conception counselling for individual patients and their families is used...
December 6, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29223726/computed-tomography-measurement-of-the-left-atrial-appendage-for-optimal-sizing-of-the-watchman-device
#17
Bo Xu, Jorge Betancor, Kimi Sato, Serge Harb, Karim Abdur Rehman, Kunal Patel, Arnav Kumar, Paul C Cremer, Wael Jaber, L Leonardo Rodriguez, Paul Schoenhagen, Oussama Wazni
INTRODUCTION: Percutaneous left atrial appendage (LAA) occlusion is an emerging treatment option for patients with non-valvular atrial fibrillation who cannot tolerate oral anticoagulation. The Watchman device (Boston Scientific Corporation, Natick, MA, USA) is deployed at the ostium of the LAA, and an appropriately sized device is critical for successful occlusion. However, standardized imaging protocols for device sizing have not been established. OBJECTIVES: We investigated the clinical utility of a standardized imaging protocol, with pre-procedural multi-detector cardiac computed tomography (MDCT), and intra-procedural transesophageal echocardiography (TEE), for Watchman device sizing...
December 5, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29223658/can-technology-really-help-to-reduce-underage-drinking-new-evidence-on-the-effects-of-false-id-laws-with-scanner-provisions
#18
Emily Yiying Zheng
In Volume 36 of this journal, Yoruk (2014) uses data from the National Longitudinal Survey of Youth 1997 and finds that false ID laws with scanner provisions have large impacts on binge drinking participation, frequency of alcohol consumption and binge drinking frequency among minors. This paper reexamines how false ID laws with scanner provisions affect underage drinking. I first demonstrate that analyses based on NLSY97 data fail falsification exercises testing for significant pre-intervention effects, and that the estimated effects based on these data are highly sensitive to the inclusion of a lead term and to sample selection, which weakens confidence in the large estimated effects reported in Yoruk (2014)...
November 16, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/29223653/effects-of-cardiac-rehabilitation-on-heart-rate-recovery-of-patients-undergoing-a-cardiac-rehabilitation-programme-after-acute-coronary-syndrome
#19
Tiffany Astolfi, Fabio Borrani, Milos Savcic, Vincent Gremeaux, Grégoire P Millet
BACKGROUND: An efficient cardiac rehabilitation programme (CRP) can improve the functional ability of patients after acute coronary syndrome (ACS). OBJECTIVE: To examine the effect of a CRP on parasympathetic reactivation and heart rate recovery (HRR) measured after a 6-min walk test (6MWT), and correlation with 6MWT distance and well-being after ACS. METHODS: Eleven normoweight patients after ACS (BMI < 25kg/m2; 10 males; mean [SD] age 61 [9] years) underwent an 8-week CRP...
December 6, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29223626/sleep-and-quality-of-life-of-patients-with-glycogen-storage-disease-on-standard-and-modified-uncooked-cornstarch
#20
Isabelle Rousseau-Nepton, Céline Huot, Diane Laforte, Elise Mok, Daphna Fenyves, Evelyn Constantin, John Mitchell
BACKGROUND: Glycemic control in hepatic glycogen storage diseases (GSDs) relies on specific nutritional recommendations, including strict avoidance of a fasting period. Uncooked cornstarch (UCCS) is an important therapeutic component. A new modified UCCS, Glycosade™, was created with the objective of prolonging euglycemia. We aimed to determine the length of euglycemia on Glycosade™ using a continuous glucose monitor (CGM) and to evaluate whether longer euglycemia and thus less nighttime interruptions would improve sleep and quality of life (QoL) after the introduction of the modified cornstarch...
September 11, 2017: Molecular Genetics and Metabolism
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