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https://www.readbyqxmd.com/read/29684925/minimally-invasive-resection-of-deep-seated-high-grade-gliomas-using-tubular-retractors-and-exoscopic-visualization
#1
Rajiv Iyer, Kaisorn L Chaichana
BACKGROUND AND STUDY AIMS/OBJECTIVE:  Deep-seated high-grade gliomas (HGGs) represent a unique surgical challenge because they reside deep to critical cortical and subcortical structures and infiltrate functional areas of the brain. Therefore, accessing and resecting these tumors can often be challenging and associated with significant morbidity. We describe the use of minimally invasive approaches to access deep-seated HGGs to achieve extensive resections while minimizing surgical morbidity...
April 23, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29684871/organotrifluoroborates-as-prosthetic-groups-for-single-step-f18-labeling-of-complex-molecules
#2
REVIEW
David M Perrin
To meet the long-standing challenge of a one-step, last-stage aqueous radiofluorination method for labeling large, water-soluble molecules such as peptides, we sought a mild aqueous fluorination reaction that uses organoboron compositions, which are readily fluorinated in mild aqueous acid to give 18 F-labeled organotrifluoroborates. This robust reaction now provides new 18 F-labeled radioprosthetic groups that can be pre-conjugated to peptides and other polar molecules, and then labeled with aqueous no-carrier-added (NCA) [18 F]fluoride ion in a single step...
April 20, 2018: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29684858/a-novel-triazine-ring-compound-md568-exerts-in-vivo-and-in-vitro-effects-on-lipid-metabolism
#3
Dan Jia, Ziwen Li, Ying Gao, Yifan Feng, Weimin Li
In this study, we investigated the toxicity and biological activity of a novel triazine ring compound named magnolol derivative 568 (MD568). The LD50 of MD568 was determined in Sprague-Dawley (SD) rats by intraperitoneal injection. Treatment of high fat diet-induced obese rats with MD568 demonstrated that MD568 displayed significant anti-obesity effects. MD568 markedly reduced body weight, blood lipid contents, white adipose tissue (WAT) and liver mass in obese rats. In addition, MD568 modulated lesions in WAT through regulating PPAR-Ɣ, C/EBP-a, SREBP-1c and FABP-4 proteins in the liver through regulating PPAR-α, SREBP-1c and FABP-4...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684838/-doing-it-for-real-now-the-transition-from-healthcare-assistant-to-newly-qualified-nurse-a-qualitative-study
#4
Jan Draper
BACKGROUND: There has been increasing international research and policy interest concerning the transition from student to newly qualified nurse (NQN). However, the influence of previous employment as a healthcare assistant (HCA) on students' experiences of this transition is comparatively under-researched. AIMS AND OBJECTIVES: To explore the experiences of NQNs also employed as HCAs during their pre-registration education programme and how this prior and ongoing HCA experience influenced their transition experiences...
April 16, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29684837/patient-safety-content-and-delivery-in-pre-registration-nursing-curricula-a-national-cross-sectional-survey-study
#5
Kim Usher, Cindy Woods, Jane Conway, Jackie Lea, Vicki Parker, Fiona Barrett, Eilish O'Shea, Debra Jackson
BACKGROUND: Patient safety is a core principle of health professional practice and as such requires significant attention within undergraduate curricula. However, patient safety practice is complex requiring a broad range of skills and behaviours including the application of sound clinical knowledge within a range of health care contexts and cultures. There is very little research that explores how this is taught within Australian nursing curricula. OBJECTIVES: To examine how Australian nursing curricula address patient safety; identify where and how patient safety learning occurs; and describe who is responsible for facilitating this learning...
April 17, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29684824/a-review-of-human-biomonitoring-in-selected-southeast-asian-countries
#6
REVIEW
Zohar Barnett-Itzhaki, Marta Esteban López, Naveen Puttaswamy, Tamar Berman
Rapid development and industrialization in Southeast (SE) Asia has led to environmental pollution, potentially exposing the general population to environmental contaminants. Human biomonitoring (HBM), measurement of chemical and/or their metabolites in human tissues and fluids, is an important tool for assessing cumulative exposure to complex mixtures of chemicals and for monitoring chemical exposures in the general population. While there are national HBM programs in several developed countries, there are no such national programs in most of the SE Asian countries...
April 20, 2018: Environment International
https://www.readbyqxmd.com/read/29684809/simultaneous-effects-of-igf1-and-fadrozole-on-parthenogenesis-and-pluripotency-markers-in-chicken-embryo
#7
Zohreh Hajihoseini, Shahin Eghbalsaied
So far, a synergistic effect was detected between insulin-like growth factor-I (IGF1) and anti-aromatase for sex reversal and pre-/post-natal growth of fertilized chicken embryo. Here, we hypothesized whether the growth and sexual female-to-male reversal effects of IGF1 and an anti-aromatase, Fadrozole, could improve the development of unfertilized, parthenogenetic chicken embryos. Simultaneous administration of IGF1 and Fadrozole increased the percentage of grade A embryos from 1.7% (no injection group) to 70...
April 13, 2018: Theriogenology
https://www.readbyqxmd.com/read/29684786/gram-marks-the-spot-for-stim-commentary-on-gram-domain-proteins-specialize-functionally-distinct-er-pm-contact-sites-in-human-cells
#8
Paula Nunes, Nicolas Demaurex
GRAM domain proteins were reported as novel ER-PM tethers defining specific membrane contact sites (MCS) subdomains. GRAMD2a pre-marks the sites occupied by STIM1 at MCS and its ablation impairs STIM1 translocation, but not store-operated Ca2+ entry. We discuss these apparently counterintuitive findings in the context of STIM/ORAI signaling at MCS.
April 18, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29684701/distribution-sedimentation-and-bioavailability-of-particulate-phosphorus-in-the-mainstream-of-the-three-gorges-reservoir
#9
Xianqiang Tang, Min Wu, Rui Li
The transportation and sedimentation of particulate phosphorus (PP) in a huge reservoir such as the Three Gorges Reservoir (TGR) are closely related to the phosphorus distribution characteristics and nutritional status of the water body. In this study, the PP distribution, sedimentation, and bioavailability in the mainstream section of the TGR were investigated through a field survey, indoor simulated settlement experiment, and historical data analysis. The results indicated that PP was the major component of the total phosphorus (TP) and that the Three Gorges Dam (TGD) trapped nearly 76...
April 11, 2018: Water Research
https://www.readbyqxmd.com/read/29684651/the-geography-of-smallpox-in-england-before-vaccination-a-conundrum-resolved
#10
Romola Jane Davenport, Max Satchell, Leigh Matthew William Shaw-Taylor
Smallpox is regarded as an ancient and lethal disease of humans, however very little is known about the prevalence and impact of smallpox before the advent of vaccination (c.1800). Here we use evidence from English burial records covering the period 1650-1799 to confirm a striking geography to smallpox patterns. Smallpox apparently circulated as a childhood disease in northern England and Sweden, even where population densities were low and settlement patterns dispersed. However, smallpox was a relatively rare epidemic disease in southern England outside the largest cities, despite its commercialised economy and the growing spatial interconnectedness of its settlements...
April 16, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29684645/challenges-in-pediatric-neuroimaging
#11
REVIEW
Matthew J Barkovich, Yi Li, Rahul S Desikan, A James Barkovich, Duan Xu
Pediatric neuroimaging is challenging due the rapid structural, metabolic, and functional changes that occur in the developing brain. A specially trained team is needed to produce high quality diagnostic images in children, due to their small physical size and immaturity. Patient motion, cooperation and medical condition dictate the methods and equipment used. A customized approach tailored to each child's age and functional status with the appropriate combination of dedicated staff, imaging hardware, and software is key; these range from low-tech techniques, such as feed and swaddle, to specialized small bore MRI scanners, MRI compatible incubators and neonatal head coils...
April 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29684630/ligand-accessibility-to-the-hiv-1-env-co-receptor-binding-site-can-occur-prior-to-cd4-engagement-and-is-independent-of-viral-tier-category
#12
Saikat Boliar, Shilpa Patil, Brihaspati N Shukla, Ali Ghobbeh, Suprit Deshpande, Weizao Chen, Javier Guenaga, Dimiter S Dimitrov, Richard T Wyatt, Bimal K Chakrabarti
HIV-1 virus entry into target cells requires the envelope glycoprotein (Env) to first bind the primary receptor, CD4 and subsequently the co-receptor. Antibody access to the co-receptor binding site (CoRbs) in the pre-receptor-engaged state, prior to cell attachment, remains poorly understood. Here, we have demonstrated that for tier-1 Envs, the CoRbs is directly accessible to full-length CD4-induced (CD4i) antibodies even before primary receptor engagement, indicating that on these Envs the CoRbs site is either preformed or can conformationally sample post-CD4-bound state...
April 20, 2018: Virology
https://www.readbyqxmd.com/read/29684607/effect-of-immunization-of-rohu-labeo-rohita-with-inactivated-germinated-zoospores-in-providing-protection-against-aphanomyces-invadans
#13
Pravata K Pradhan, Neeraj Sood, Manoj K Yadav, Pooja Arya, Dharmendra K Chaudhary, Uday Kumar, Chandra Bhushan Kumar, T R Swaminathan, Gaurav Rathore
Infection with Aphanomyces invadans is one of the most destructive diseases of freshwater fishes. Indian major carps, the dominant cultured species in the Indian sub-continent are highly susceptible to this disease. Till date, there is no effective treatment for control of this disease and immunization can be one of the strategies to reduce disease-related losses. In the present study, inactivated germinated zoospores of A. invadans were evaluated as antigen in conjunction with and without adjuvant Montanide™ ISA 763 A VG, for assessing their efficacy in rendering protection against A...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684602/trans-cinnamic-acid-application-for-rainbow-trout-oncorhynchus-mykiss-i-effects-on-haematological-serum-biochemical-non-specific-immune-and-head-kidney-gene-expression-responses
#14
Sevdan Yilmaz, Sebahattin Ergün
The present study investigated the effects of dietary trans-cinnamic acid (CA) on pre- and post-challenge haematological, serum biochemical, non-specific immune and head kidney gene expression responses of rainbow trout, Oncorhynchus mykiss juveniles. In this regard, fish with an average weight of 17.01 ± 0.05 g were divided into five groups, and fed daily with an additive free basal diet (control); 250, 500, 750 or 1500 mg kg-1  CA for a 60-day period. Fish were sampled every 20 days during the experiment...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684586/targeted-biochemical-profiling-of-brain-from-huntington-s-disease-patients-reveals-novel-metabolic-pathways-of-interest
#15
Stewart F Graham, Xiaobei Pan, Ali Yilmaz, Shirin Macias, Andrew Robinson, David Mann, Brian D Green
Huntington's disease (HD) is a devastating, progressive neurodegenerative disease with a distinct phenotype characterized by chorea and dystonia, incoordination, cognitive decline and behavioral difficulties. The precise mechanisms of HD progression are poorly understood; however, it is known that there is an expansion of the trinucleotide cytosine-guanosine-guanine (CAG) repeat in the Huntingtin gene. Herein DI/LC-MS/MS was used to accurately identify and quantify 185 metabolites in post mortem frontal lobe and striatum from HD patients and healthy control cases...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684573/bevacizumab-reduces-s100a9-mdsc-linked-to-intracranial-control-in-patients-with-egfr-mutant-lung-adenocarcinoma
#16
Po-Hao Feng, Kuan-Yuan Chen, Yu-Chen Huang, Ching-Shan Luo, Shen Ming Wu, Tzu-Tao Chen, Chun-Nin Lee, Chi-Tai Yeh, Hsiao-Chi Chuang, Chia-Li Han, Chiou-Feng Lin, Wei-Hwa Lee, Chih-Hsi Kuo, Kang-Yun Lee
BACKGROUND: In vitro models have demonstrated immune-modulating effects of bevacizumab. Combinations of EGFR tyrosine kinase inhibitor (TKI) with bevacizumab improve progression free survival (PFS) in patients with EGFR mutated lung adenocarcinoma. How bevacizumab confers this clinical effect and underlying mechanisms are not clear. PATIENT AND METHODS: Fifty-five patients with stage 4 EGFR mutated lung adenocarcinoma were enrolled. Myeloid derived suppressor cells (MDSCs), T helper cells (Th1/Th2) and cytotoxic T lymphocytes (CTLs) were analyzed by flow cytometry...
April 20, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29684564/deep-npm1-sequencing-following-allogeneic-hematopoietic-cell-transplantation-improves-risk-assessment-in-adults-with-npm1-mutated-aml
#17
Yi Zhou, Megan Othus, Roland B Walter, Elihu H Estey, David Wu, Brent L Wood
Relapse is the major cause of death in patients with acute myeloid leukemia (AML) after allogeneic hematopoietic cell transplant (HCT). Measurable residual disease (MRD) detected by multiparameter flow cytometry (MFC) before and after HCT is a strong, independent risk factor for relapse. As next generation sequencing (NGS) is increasingly applied in AML MRD detection, it remains to be determined if NGS can improve prediction of post-HCT relapse. Herein, we investigated pre-HCT MRD detected by MFC and NGS in 59 adult patients with NPM1-mutated AML in morphologic remission; 45 of the 59 had post-HCT MRD determined by MFC and NGS around day 28...
April 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29684562/bmt-following-non-myeloablative-treosulfan-conditioning-is-curative-in-a-murine-model-of-sickle-cell-disease
#18
Divya Devadasan, Chiao-Wang Sun, Erik R Westin, Li-Chen Wu, Kevin M Pawlik, Tim M Townes, Frederick D Goldman
Allogeneic hematopoietic stem cell transplantation (HSCT) can be curative for patients with sickle cell disease (SCD). However, morbidity associated with myeloablative conditioning and graft versus host disease has limited its utility. To this end, autologous HSCT for SCD using lentiviral gene-modified bone marrow (BM) or peripheral blood stem cells has been undertaken, though toxicities of fully ablative conditioning with busulfan and incomplete engraftment have been encountered. Treosulfan, a busulfan analog with a low extra-medullary toxicity profile, has been employed successfully as part of a myeloablative conditioning regimen in the allogeneic setting in SCD...
April 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29684537/genetic-imaging-study-with-tc-99m-trodat-1-spect-in-adolescents-with-adhd-using-oros-methylphenidate
#19
Aynur Pekcanlar Akay, Gamze Çapa Kaya, Samet Kose, Çiğdem Eresen Yazıcıoğlu, Handan Özek Erkuran, Sevay Alşen Güney, Kaya Oğuz, Duygu Keskin, Burak Baykara, Neslihan İnal Emiroğlu, Mine Şencan Eren, Sefa Kızıldağ, Türkan Ertay, Dua Özsoylu, Süha Miral, Hatice Durak, Ali Saffet Gönül, Luis Augusto Rohde
AIM: To examine theeffects on the brain of 2-month treatment withamethylphenidate extended-release formulation (OROS-MPH) using [Tc-99m ] TRODAT-1SPECT in a sample of treatment-naïve adolescents with Attention Deficit/Hyperactivity Disorder (ADHD). In addition, to assess whether risk alleles (homozygosity for 10-repeat allele at the DAT1 gene were associated with alterations in striatal DAT availability. METHODS: Twenty adolescents with ADHD underwent brain single-photon emission computed tomography (SPECT) scans with [Tc-99m ] TRODAT-1 at baseline and two months after starting OROS-MPH treatment with dosages up to 1 mg/kg/day...
April 20, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29684534/towards-a-maraviroc-long-acting-injectable-nanoformulation
#20
Lee M Tatham, Alison C Savage, Andrew Dwyer, Marco Siccardi, Trevor Scott, Manoli Vourvahis, Andrew Clark, Steven P Rannard, Andrew Owen
Suboptimal adherence to antiretroviral (ARV) therapy can lead to insufficient drug exposure leading to viral rebound and increased likelihood of resistance. This has driven the development of long-acting injectable (LAI) formulations which may mitigate some of these problems. Maraviroc (MVC) is an orally dosed CCR5 antagonist approved for use in patients infected with CCR5-trophic HIV-1. MVC prevents viral entry into host cells, is readily distributed to biologically relevant tissues and has an alternative resistance profile compared to more commonly used therapies...
April 20, 2018: European Journal of Pharmaceutics and Biopharmaceutics
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