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https://www.readbyqxmd.com/read/29679925/tocotrienol-rich-fraction-supplementation-reduces-hyperglycemia-induced-skeletal-muscle-damage-through-regulation-of-insulin-signaling-and-oxidative-stress-in-type-2-diabetic-mice
#1
Heaji Lee, Yunsook Lim
Chronic hyperglycemia induces impairment of muscle growth and development of diabetes mellitus (DM). Since skeletal muscle is the major site for disposal of ingested glucose, impaired glucose metabolism causes imbalance between protein synthesis and degradation which adversely affects physical mobility. In this study, we investigated the effect of tocotrienol-rich fraction (TRF) supplementation on skeletal muscle damage in diabetic mice. Diabetes was induced by a high-fat diet with streptozotocin (STZ) injection (100 mg/kg) in male C57BL/6J mice...
March 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29679761/expression-profiling-and-microbial-ligand-binding-analysis-of-high-mobility-group-box-1-hmgb1-in-turbot-scophthalmus-maximus-l
#2
Xin Cai, Chengbin Gao, Baofeng Su, Fenghua Tan, Ning Yang, Guodong Wang
High-mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, was involved in nucleosome formation and transcriptional regulation, and can also act as an extracellular cytokine to trigger inflammation and immune responses. In this study, we identified a HMGB1 gene in turbot (Scophthalmus maximus L.). The full-length SaHMGB1 cDNA includes an open reading frame of 615 bp which encoded a 204 amino acid polypeptide with an estimated molecular mass of 23.19°kDa. SaHMGB1 was most closely related to several fish HMGB1 and shared 74...
April 18, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29679753/daidzein-rich-isoflavone-aglycones-inhibit-cell-growth-and-inflammation-in-endometriosis
#3
O Takaoka, T Mori, F Ito, H Okimura, H Kataoka, Y Tanaka, A Koshiba, I Kusuki, S Shigehiro, T Amami, J Kitawaki
Endometriosis is an estrogen-dependent disease, and isoflavones interact with estrogen receptors. The purposes of this study are to investigate the in vitro and in vivo effects of daidzein-rich isoflavone aglycones (DRIAs), dietary supplements, on cellular proliferation in endometriosis. Stromal cells isolated from ovarian endometrioma (OESCs) and normal endometrium (NESCs) were cultured with DRIAs, i.e., each of the DRIA components (daidzein, genistein, or glycitein), or isoflavone glycosides (IG; DRIA precursors)...
April 18, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29679702/alamandine-attenuates-sepsis-associated-cardiac-dysfunction-via-inhibiting-mapks-signaling-pathways
#4
Peng Li, Xi-Ru Chen, Fei Xu, Chi Liu, Chang Li, Hui Liu, Hui Wang, Wei Sun, Yan-Hui Sheng, Xiang-Qing Kong
Sepsis-induced myocardial dysfunction represents a major cause of death in intensive care units. Alamandine is an important biologically active peptide in the renin-angiotensin system. The present study evaluated whether alamandine improves cardiac dysfunction, inflammation, and apoptosis, and affects the signaling pathways involved in these events. Experiments were carried out in mice treated with lipopolysaccharide (LPS) or alamandine, and in neonatal rat cardiomyocytes. Alamandine increased the ejection fraction and fractional shortening, both of which were decreased upon LPS infusion in mice...
April 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29679701/the-role-of-%C3%AE-2-integrin-associated-heparin-binding-protein-release-in-ards
#5
Yang Liu, Shaolin Ma, Xuebin Wang, Yajing Feng, Shouqin Zhang, Sheng Wang, Xiangyu Zhang
AIMS: PMNs (polymorphonuclear neutrophil) play important roles in early stage of inflammation induced ARDS (Acute Respiratory Distress Syndrome). Both HBP (Heparin-Binding Protein) released from active PMNs and β2 integrins on the surface of PMNs are involved in vascular leakage. The role and relationship of HBP and β2 integrins on ARDS still requires study. MATERIALS AND METHODS: We established ARDS model using C57BL/6 mice with cecal ligation and puncture and eliminating HBP and β2 integrin with respective antibodies...
April 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29679637/recent-stimulant-use-and-leukocyte-gene-expression-in-methamphetamine-users-with-treated-hiv-infection
#6
Adam W Carrico, Annesa Flentje, Kord Kober, Sulggi Lee, Peter Hunt, Elise D Riley, Steven Shoptaw, R N Elena Flowers, Samantha E Dilworth, Savita Pahwa, Bradley E Aouizerat
Stimulant use may accelerate HIV disease progression through biological and behavioral pathways. However, scant research with treated HIV-positive persons has examined stimulant-associated alterations in pathophysiologic processes relevant to HIV pathogenesis. In a sample of 55 HIV-positive, methamphetamine-using sexual minority men with a viral load less than 200 copies/mL, we conducted RNA sequencing to examine patterns of leukocyte gene expression in participants who had a urine sample that was reactive for stimulants (n = 27) as compared to those who tested non-reactive (n = 28)...
April 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29679615/novel-protective-role-of-kallistatin-in-obesity-by-limiting-adipose-tissue-low-grade-inflammation-and-oxidative-stress
#7
Gema Frühbeck, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Sara Becerril, Xabier Unamuno, Camilo Silva, Javier Salvador, Victoria Catalán
OBJECTIVE: Kallistatin plays an important role in the inhibition of inflammation, oxidative stress, fibrosis and angiogenesis. We aimed to determine the impact of kallistatin on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and oxidative stress. METHODS: Samples obtained from 95 subjects were used in a case-control study. Circulating concentrations and expression levels of kallistatin as well as key inflammation, oxidative stress and extracellular matrix remodelling-related genes were analyzed...
April 18, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29679568/induction-of-s100a9-homodimer-formation-in-vivo
#8
Eva Källberg, Sahar Tahvili, Fredrik Ivars, Tomas Leanderson
We show here that increased S100A8 and S100A9 protein expression is induced in spleen of animals with active inflammation or with inoculated tumors. In tumor bearing animals an increased expression was also detected in the lung. To further analyze the induced proteins, we performed chemical cross-linking followed by Western blotting. We observed in protein extracts from spleen that both S100A8/S100A9 heterodimers as well as S100A9 homodimers were formed, both after tumor and inflammatory challenge. The cellular source for S100A9 homodimers were CD11b+ GR1+ cells...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29679566/matrix-stiffness-regulate-apoptotic-cell-death-in-hiv-hcv-co-infected-hepatocytes-importance-for-liver-fibrosis-progression
#9
Murali Ganesan, Raghubendra Singh Dagur, Edward Makarov, Larisa I Poluektova, Srivatsan Kidambi, Natalia A Osna
HIV-HCV co-infection causes rapid progression of liver fibrosis. These outcomes to liver cirrhosis can be improved, but not stopped by specific antiviral therapies. Due to high significance of HIV-HCV interactions for morbidity and mortality in co-infected patients, our attention was attracted to the multi-component pathogenesis of fibrosis progression as the transition to end-stage liver disease development. In this study, we hypothesize that increased matrix stiffness enhances apoptosis in HCV-HIV-co-infected hepatocytes and that capturing of apoptotic bodies (AB) derived from these infected hepatocytes by hepatic stellate cells (HSC) drives the fibrosis progression...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29679557/acetaminophen-induced-liver-injury-is-attenuated-in-transgenic-fat-1-mice-endogenously-synthesizing-long-chain-n-3-fatty-acids
#10
Ruibing Feng, Yang Wang, Conghui Liu, Chunyan Yan, Hang Zhang, Huanxing Su, Jing X Kang, Chang-Zhen Shang, Jian-Bo Wan
Acetaminophen (APAP) overdose-caused hepatotoxicity is the most commonly cause of drugs-induced liver failurecharacterized by oxidative stress, mitochondrial dysfunction, and cell damage. Therapeutic efficacy of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in several models of liver disease is well documented. However, the impacts of n-3 PUFA on APAP hepatotoxicity are not adequately addressed. In this study, the fat-1 transgenic mice that synthesize endogenous n-3 PUFA and wild type (WT) littermates were injected intraperitoneally with APAP at the dose of 400 mg/kg to induce liver injury, and euthanized at 0 h, 2 h, 4 h and 6 h post APAP injection for sampling...
April 18, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29679522/oropharyngeal-squamous-cell-carcinoma-induces-an-innate-systemic-inflammation-affected-by-the-size-of-the-tumor-and-the-lymph-node-spread
#11
Åsa Kågedal, Camilla Rydberg Millrud, Valtteri Häyry, Susanna Kumlien Georén, Mats Lidegran, Eva Munck-Wikland, Lars Olaf Cardell
OBJECTIVES: Inflammation is known to be associated with the progression of cancer. The study was designed to characterize the systemic inflammation in patients with oropharyngeal squamous cell carcinoma (OPSCC) and investigate its relation to tumor size, ability to metastasize and HPV status. MATERIALS AND METHODS: Blood was obtained from 58 patients with OPSCC and 90 healthy controls and analyzed with leukocyte differential count. RESULTS: The OPSCC patients displayed an increased number of neutrophils and monocytes, whereas the lymphocytes were suppressed compared to the healthy controls...
April 21, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29679494/risk-of-sun-induced-skin-cancers-in-patients-with-alopecia-areata-alopecia-totalis-and-alopecia-universalis
#12
Rosalynn R Z Conic, Rose Miller, Melissa Piliang, Wilma Bergfeld, Natasha Atanaskova Mesinkovska
Alopecia areata (AA) is an autoimmune non-scarring hair loss characterized by round patches on the scalp and body. It can progress to alopecia totalis (AT) where there is total loss of scalp hair and alopecia universalis (AU) in where hair loss encompasses the entire body. The pathophysiologic mechanism is unclear, but is thought to be due to peribulbar T-cell inflammation which results in premature induction of anagen follicles to catagen and telogen, without causing destruction of the hair follicle. This article is protected by copyright...
April 21, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29679488/randomised-clinical-trial-of-the-effects-of-azithromycin-use-in-the-treatment-of-peri-implantitis
#13
Leon Gershenfeld, Alex Kalos, Terry Whittle, Stephen Yeung
AIM: The aim of this clinical trial was to establish a proof of concept that the adjunctive use of systemic azithromycin (AZM) in conjunction with mechanical debridement has an increased benefit in reducing soft tissue inflammation in the treatment of peri-implantitis. MATERIALS AND METHODS: In a randomised, double blind, clinical trial, the treatment group (9 patients) received AZM as well as mechanical debridement in a single course of treatment, whereas the control group (8 patients) received a placebo and mechanical debridement...
April 21, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29679485/identification-and-structure-elucidation-of-the-proresolving-mediators-provides-novel-leads-for-resolution-pharmacology
#14
REVIEW
Jesmond Dalli, Charles N Serhan
Inflammatory diseases are a major socioeconomic burden, with the incidence of such conditions on the rise, especially in western societies. For decades, the primary treatment paradigm for many of these conditions was to develop drugs that inhibit or antagonize the production and biological actions of molecules that were thought to be the culprits in propagating disease, these include cytokines and eicosanoids. This approach is effective in controlling disease propagation; however, long-term exposure to these anti-inflammatories is also associated with many side effects, some of which severe, including immune-suppression...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679484/the-role-of-autoimmune-reactivity-induced-by-heat-shock-protein-70-in-the-pathogenesis-of-essential-hypertension
#15
REVIEW
Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
Autoimmunity is increasingly recognized as having a central role in essential hypertension. Heat shock proteins are immunodominant molecules with high interspecies homology and autoimmune reactivity directed against HSP70 may play a role in the pathogenesis of hypertension. Autoimmunity to HSP70 may result from molecular mimicry between human HSP and bacterial HSP, or alternatively, as a response to HSP70-peptide complexes generated during cellular stress and delivered to the major histocompatibility complex in antigen presenting cells...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679391/cardiovascular-effects-of-sitagliptin-an-anti-diabetes-medicine
#16
REVIEW
Yi Zhou, Zhiying Guo, Wenjing Yan, Wen Wang
Dipeptidyl-peptidase-4 (DPP-4) inhibitors, as the most recent available anti-diabetic agents, were generally used in clinical treatment of type 2 diabetes (T2DM). In addition to anti-diabetic effects, the five most widely used DPP-4 inhibitors (sitagliptin, vildagliptin, saxagliptin, linagliptin and alogliptin) also exert cardiovascular protective effects. In recent years, increasing studies suggest that sitagliptin shows pleiotropic impacts towards the cardiovascular system either with or without diabetes...
April 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29679313/effects-of-different-natural-extracts-in-an-experimental-model-of-benign-prostatic-hyperplasia-bph
#17
Irene Paterniti, Michela Campolo, Marika Cordaro, Rosalba Siracusa, Antonio Filippone, Emanuela Esposito, Salvatore Cuzzocrea
OBJECTIVE AND DESIGN: To characterize the impact of inflammatory process and oxidative stress in the degree of benign prostatic hyperplasia (BPH), a common condition in which chronic inflammation plays a crucial role, we investigated the effect of different plant extract preparations in an in vivo model of BPH as new therapeutic target. MATERIAL: BPH was made in rats with daily administration of testosterone propionate (3 mg/kg) for 14 days. TREATMENT: Rats were randomized into different groups to receive oral administration of plant extract preparations: Serenoa repens with selenium (SeR 28...
April 20, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29679227/cypd-mptp-axis-regulates-mitochondrial-functions-contributing-to-osteogenic-dysfunction-of-mc3t3-e1-cells-in-inflammation
#18
Xueqi Gan, Ling Zhang, Beilei Liu, Zhuoli Zhu, Yuting He, Junsheng Chen, Junfei Zhu, Haiyang Yu
Bone is a dynamic organ, the bone-forming osteoblasts and bone-resorbing osteoclasts form the physiological basis of bone remodeling process. During pathological process of numerous inflammatory diseases, these two aspects are uncoupled and the balance is usually tipped in favor of bone destruction. Evidence suggests that the inflammatory destruction of bone is mainly attributed to oxidative stress and is closely related to mitochondrial dysfunction. The mechanisms underlying osteogenic dysfunction in inflammation still need further investigation...
April 20, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29679204/efficacy-of-curcumin-for-age-associated-cognitive-decline-a-narrative-review-of-preclinical-and-clinical-studies
#19
REVIEW
Marjana Rahman Sarker, Susan F Franks
Processes such as aberrant redox signaling and chronic low-grade systemic inflammation have been reported to modulate age-associated pathologies such as cognitive impairment. Curcumin, the primary therapeutic component of the Indian spice, Turmeric (Curcuma longa), has long been known for its strong anti-inflammatory and antioxidant activity attributable to its unique molecular structure. Recently, an interest in this polyphenol as a cognitive therapeutic for the elderly has emerged. The purpose of this paper is to critically review preclinical and clinical studies that have evaluated the efficacy of curcumin in ameliorating and preventing age-associated cognitive decline and address the translational progress of preclinical to clinical efficacy...
April 21, 2018: GeroScience
https://www.readbyqxmd.com/read/29679171/pedicled-gastric-seromuscular-patch-for-one-stage-closure-of-a-bronchopleural-fistula-a-case-report
#20
Jun Suzuki, Hiroyuki Oizumi, Hirohisa Kato, Akira Hamada, Hikaru Watarai, Kenta Nakahashi, Takayuki Sasage, Mitsuaki Sadahiro
BACKGROUND: One-stage closure and fenestration are the available surgical options for bronchopleural fistula (BPF). One-stage closure may be applicable in cases with favorable infection control. Closing the bronchopleural stump is difficult due to thick adhesion caused by inflammation and a high risk of pulmonary artery injury. We report the successful closure of a BPF using a gastric seromuscular patch with an omental pedicle flap. CASE PRESENTATION: A 73-year-old man underwent right lower lobectomy with ND2a-2 lymph node dissection for lung adenocarcinoma...
April 20, 2018: Surgical Case Reports
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