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https://www.readbyqxmd.com/read/28454345/high-il-17-expression-is-associated-with-an-unfavorable-prognosis-in-thyroid-cancer
#1
Denise Faria Galano Carvalho, Bruna Riedo Zanetti, Lydianne Miranda, Marcela Kazue Hassumi-Fukasawa, Fabiana Miranda-Camargo, Janaína Cristiana Oliveira Crispim, Edson Garcia Soares
Previous studies have indicated that cancer may be promoted and/or exacerbated by inflammation and infection. The cytokines produced by activated innate immune cells that stimulate tumor growth and progression are considered as important components in this process. The interleukin (IL)-23/T helper (Th)17 axis, which exerts marked pro-inflammatory effects, has emerged as an important mediator in inflammation-associated cancer. Increasing clinical evidence indicates that Th17 may promote or inhibit tumor progression, however, the function of Th17 in the pathogenesis of benign and malignant thyroid neoplasms remains unclear...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454279/anticancer-activity-of-nelumbo-nucifera-stamen-extract-in-human-colon-cancer-hct-116-cells-in-vitro
#2
Xin Zhao, Xia Feng, Cun Wang, Deguang Peng, Kai Zhu, Jia-Le Song
The aim of the present study was to investigate the anticancer activities of Nelumbo nucifera (Ba lotus) stamen ethanol crude extract (BLSEE) in human colon carcinoma HCT-116 cells. MTT assay, flow cytometry analysis and reverse transcription-polymerase chain reaction assay were employed to investigate the anticancer mechanisms of BLSEE (100, 200 and 400 µg/ml) in HCT-116 cells. BLSEE reduced HCT-116 cell proliferation in a dose-dependent manner. BLSEE treatment also significantly increased the sub-G1 population in HCT-116 cells (P=0...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454264/luteolin-a-novel-p90-ribosomal-s6-kinase-inhibitor-suppresses-proliferation-and-migration-in-leukemia-cells
#3
Lan Deng, Ling Jiang, Xianghua Lin, Kuo-Fu Tseng, Zhigang Lu, Xiuju Wang
Ribosomal S6 kinases (RSKs) are directly regulated by extracellular signal-regulated kinase (ERK) signaling and are implicated in cell growth, survival, motility and senescence. The present study observed that RSK1 was overexpressed in primary untreated leukemia patient bone marrow samples compared with the expression at the complete remission stage, using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In addition, a high RSK1 expression (relative expression ≥10) was associated with a significantly shorter overall survival (P=0...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454210/statins-and-pancreatic-cancer
#4
Jun Gong, Esha Sachdev, Lori A Robbins, Emily Lin, Andrew E Hendifar, Monica M Mita
Pancreatic cancer remains among the most lethal cancers, despite ongoing advances in treatment for all stages of the disease. Disease prevention represents another opportunity to improve patient outcome, with metabolic syndrome and its components, such as diabetes, obesity and dyslipidemia, having been recognized as modifiable risk factors for pancreatic cancer. In addition, statins have been shown to potentially reduce pancreatic cancer risk and to improve survival in patients with a combination of metabolic syndrome and pancreatic cancer...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454190/evaluation-of-the-effect-of-epilobium-angustifolium-aqueous-extract-on-lncap-cell-proliferation-in-in-vitro-and-in-vivo-models
#5
Jakub P Piwowarski, Barbara Bobrowska-Korczak, Iwona Stanisławska, Wojciech Bielecki, Robert Wrzesien, Sebastian Granica, Katarzyna Krupa, Anna K Kiss
Epilobium sp. are commonly used in traditional medicine in the treatment of early stages of benign prostatic hyperplasia and inflammation. It is suggested that a dominating constituent, oenothein B, is responsible for the extracts therapeutic effects. Several bioactivities were established for extracts and oenothein B in various in vitro models, but due to the questionable bioavailability of this dimeric macrocyclic ellagitannin, their significance in the in vivo effects remains unresolved. We have thus focused our attention on a complex comparative investigation of the in vitro and in vivo activities of phytochemically characterized Epilobium angustifolium aqueous extract and oenothein B on prostate cancer cells proliferation...
April 28, 2017: Planta Medica
https://www.readbyqxmd.com/read/28454116/neuroprotection-by-ifn-%C3%AE-via-astrocyte-secreted-il-6-in-acute-neuroinflammation
#6
Lijie Sun, Yan Li, Xiuzhi Jia, Qi Wang, Yue Li, Minghui Hu, Linlu Tian, Jinfeng Yang, Wenjing Xing, Weihua Zhang, Jingtao Wang, Hongwei Xu, Lihua Wang, Dekai Zhang, Huan Ren
Inflammation eliminates pathogenic infections while also threatening the integrity of the central nervous system. In this study, using in vivo and in vitro models of acute neuroinflammation, we investigated the mechanisms by which inflammation and astrocytes affect neuronal apoptosis. The in vitro model mimicked acute neuroinflammation by incubation in IFN-γ-containing media with primary cultured cerebellar granule neurons, with or without cultured astrocytes. This quickly induced neuronal apoptosis characterized by cleaved caspase-3 expression, Hoechst 33342 staining, and intercellular Ca2+ influx, whereas the presence of astrocytes significantly protected neurons from these effects...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454097/upregulation-of-calprotectin-in-mild-ige-mediated-ovalbumin-hypersensitivity
#7
Qingling Zhu, Feng Li, Junli Wang, Jingqiu Ma, Xiaoyang Sheng
Calprotectin, also known as S100A8/A9, has been linked to gut inflammation caused by IgE-mediated food hypersensitivities, but the pathophysiologic abnormalities it causes remain to be determined. We created a mild food hypersensitivity model through oral gavage of ovalbumin in Norway brown rats without using immune adjuvant. Changes in the levels of calprotectin and inflammation-associated cytokines were then observed over time. We found that fecal calprotectin as well as jejunal and liver TLR4, TNF-α, NF-κB, IL-1β, and IL-6 were upregulated in hypersensitive rats...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454090/peroxiredoxin-6-overexpression-attenuates-lipopolysaccharide-induced-acute-kidney-injury
#8
Dong Hun Lee, Ju Ho Park, Sang Bae Han, Do Young Yoon, Yu Yeon Jung, Jin Tae Hong
Peroxiredoxin 6 (PRDX6) is a member of the PRDX family of antioxidant enzymes and correlated with inflammatory response. Therefore, we investigated the role of PRDX6 during lipopolysaccharide (LPS)-induced acute kidney injury. Both 3 months aged PRDX6-overexpressing transgenic mice (PRDX6 mice) and wild type (WT) mice had acute renal injury induced by intraperitoneal injection of LPS (10 mg/kg)., PRDX6 mice showed decreased mortality and renal injury following LPS challenge compared to WT mice. Furthermore, infiltration of macrophages, T-cells and neutrophils, and the number of apoptotic cells were more decreased by LPS treatment in PRDX6 mice than in WT mice...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454064/withaferin-a-a-steroidal-lactone-encapsulated-mannose-decorated-liposomes-ameliorates-rheumatoid-arthritis-by-intriguing-the-macrophage-repolarization-in-adjuvant-induced-arthritic-rats
#9
Farhath Sultana, Manoj Kumar Neog, MahaboobKhan Rasool
In order to develop a better therapeutic approach for the treatment of rheumatoid arthritis (RA), withaferin-A; a steroidal lactone incorporated with mannosylated liposomes (ML-WA) was administered to adjuvant induced arthritic rats in intent to target the synovial macrophages. The confocal microscopy studies showed a successful internalization of ML-WA in the primarily isolated synovial macrophages. Consequently, targeting synovial macrophages via ML-WA reduced the oxidative stress (ROS and NO), and paw edema, however, a progressive gain in the body weight was observed in AIA rats...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28454041/long-term-intake-of-a-high-protein-diet-increases-liver-triacylglycerol-deposition-pathways-and-hepatic-signs-of-injury-in-rats
#10
Rubén Díaz-Rúa, Jaap Keijer, Andreu Palou, Evert M van Schothorst, Paula Oliver
Intake of high-protein (HP) diets has increased over the last years, mainly due to their popularity for body weight control. Liver is the main organ handling ingested macronutrients and it is associated with the beginning of different pathologies. We aimed to deepen our knowledge on molecular pathways affected by long-term intake of an HP diet. We performed a transcriptome analysis on liver of rats chronically fed with a casein-rich HP diet and analyzed molecular parameters related to liver injury. Chronic increase in the dietary protein/carbohydrate ratio up-regulated processes related with amino acid uptake/metabolism and lipid synthesis, promoting a molecular environment indicative of hepatic triacylglycerol (TG) deposition...
April 19, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28453961/diabetic-nephropathy-new-insights-into-established-therapeutic-paradigms-and-novel-molecular-targets
#11
REVIEW
Dilip Sharma, Pallab Bhattacharya, Kiran Kalia, Vinod Tiwari
Diabetic nephropathy is one of the most prevalent microvascular complication in patients suffering from diabetes and is reported to be the major cause of renal failure when compared to any other kidney disease. Currently, available therapies provide only symptomatic relief and unable to treat the underlying pathophysiology of diabetic nephropathy. This review will explore new insights into the established therapeutic paradigms targeting oxidative stress, inflammation and endoplasmic reticulum stress with the focus on recent clinical developments...
April 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28453960/implication-of-a-novel-gla-containing-protein-gas6-in-the-pathogenesis-of-insulin-resistance-impaired-glucose-homeostasis-and-inflammation-a-review
#12
REVIEW
Anjum Dihingia, Jatin Kalita, Prasenjit Manna
Growth arrest specific 6 (Gas6), a vitamin K-dependent protein plays a significant role in the regulation of cellular homeostasis via binding with TAM-receptor tyrosine kinases. Several studies reported the role of Gas6 in cancer, glomerular injury, obesity, and inflammation, however, very little is known about its role in insulin resistance (IR) and impaired glucose metabolism. Majority of the studies reported an inverse correlation of Gas6 protein levels or gene polymorphism with plasma glucose, HbA1c, IR, and inflammatory cytokines among type 2 diabetes (T2D) and obese subjects...
April 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28453868/combined-aerobic-and-resistance-training-decreases-inflammation-markers-in-healthy-men
#13
J K Ihalainen, M Schumann, D Eklund, M Hämäläinen, E Moilanen, G Paulsen, K Häkkinen, A A Mero
BACKGROUND AND AIMS: Our primary aim was to study the effects of 24 weeks of combined aerobic and resistance training performed on the same day or on different days on inflammation markers. METHODS AND RESULTS: Physically active, healthy young men were randomly divided into three groups that performed: aerobic and resistance training consecutively in the same training session (SS) 2-3 d·wk(-1) or on alternating days (AD) 4-6 d·wk(-1) as well as control (C). The total training volume was matched in the training groups...
April 28, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28453850/a-novel-ligand-of-toll-like-receptor-4-from-the-sheath-of-wuchereria-bancrofti-microfilaria-induces-proinflammatory-response-in-macrophages
#14
Suprabhat Mukherjee, Sandip Mukherjee, Tushar K Maiti, Samir Bhattacharya, Santi P Sinha Babu
Background.: Lymphatic filariasis, frequently caused from Wuchereria bancrofti infection, is endemic in several parts of the globe and responsible for human health problems and socioeconomic loss to a large extent. Inflammatory consequences originating from host-parasite interaction play a major role in the disease pathology and allied complications. The identity of the key mediator of this process is yet unknown in filarial research. Methods.: Microfilarial protein (MfP) was isolated from the sheath of W...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28453847/human-immunodeficiency-virus-persistence-and-t-cell-activation-in-blood-rectal-and-lymph-node-tissue-in-human-immunodeficiency-virus-infected-individuals-receiving-suppressive-antiretroviral-therapy
#15
Gabriela Khoury, Rémi Fromentin, Ajantha Solomon, Wendy Hartogensis, Marisela Killian, Rebecca Hoh, Ma Somsouk, Peter W Hunt, Valerie Girling, Elizabeth Sinclair, Peter Bacchetti, Jenny L Anderson, Frederick M Hecht, Steven G Deeks, Paul U Cameron, Nicolas Chomont, Sharon R Lewin
Background.: Immune activation and inflammation remain elevated in human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) and may contribute to HIV persistence. Methods.: Using flow cytometry expression of CD38, HLA-DR and PD-1 were measured in blood (n = 48), lymph node (LN; n = 9), and rectal tissue (n = 17) from virally suppressed individuals. Total and integrated HIV DNA, 2-LTR circles, and cell-associated unspliced HIV RNA were quantified...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28453843/inflammation-and-immune-activation-in-antiretroviral-treated-human-immunodeficiency-virus-type-1-infected-african-infants-and-rotavirus-vaccine-responses
#16
Priyanka Uprety, Jane C Lindsey, Myron J Levin, Kaitlin Rainwater-Lovett, Carrie Ziemniak, Mutsa Bwakura-Dangarembizix, Susan S Kaplan, Micki Nelson, Amanda Zadzilka, Adriana Weinberg, Deborah Persaud
00880698.
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28453771/interplay-between-ifn-%C3%AE-and-il-6-impacts-the-inflammatory-response-and-expression-of-interferon-regulated-genes-in-environmental-induced-autoimmunity
#17
David M Cauvi, Gabrielle Cauvi, Christopher B Toomey, Eric Jacquinet, K Michael Pollard
IFN-γ has been found to be robustly important to disease pathogenesis in both idiopathic and induced models of murine lupus. In transgenic mice, over production of IFN-γ in the skin results in an inflammatory response and autoimmunity. This suggests that localized exposure to environmental factors that induce autoimmunity may be associated with expression of an IFN-γ dependent inflammatory response. Using murine mercury-induced autoimmunity (mHgIA), the severity of inflammation and proinflammatory cytokine expression, including the cellular source of IFN-γ, were assessed at the site of subcutaneous exposure and in secondary lymphoid organs...
April 26, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28453768/%C3%AE-e%C3%AE-7-integrin-identifies-subsets-of-pro-inflammatory-colonic-cd4-t-lymphocytes-in-ulcerative-colitis
#18
Christopher A Lamb, John C Mansfield, Gaik W Tew, Deena Gibbons, Anna K Long, Peter Irving, Lauri Diehl, Jeff Eastham-Anderson, Maria B Price, Graeme O'Boyle, David E J Jones, Sharon O'Byrne, Adrian Hayday, Mary E Keir, Jackson G Egen, John A Kirby
Background and Aims: The αEβ7 integrin is crucial for retention of T lymphocytes at mucosal surfaces through its interaction with E-cadherin. Pathogenic or protective functions of these cells during human intestinal inflammation, such as ulcerative colitis [UC], have not previously been defined, with understanding largely derived from animal model data. Defining this phenotype in human samples is important for understanding UC pathogenesis and is of translational importance for therapeutic targeting of αEβ7-E-cadherin interactions...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28453760/long-term-inflammation-transforms-intestinal-epithelial-cells-of-colonic-organoids
#19
Shuji Hibiya, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Nobukatsu Horita, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Natsuko Kimura, Tatsunori Nishimura, Noriko Gotoh, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe
Background and Aims: Patients with ulcerative colitis [UC] are at an increased risk of developing colitis-associated cancer [CAC], suggesting that continuous inflammation in the colon promotes the transformation of colonic epithelial cells. However, the mechanisms underlying cell transformation in UC remain unknown. We therefore aimed to investigate the effect of long-term inflammation on intestinal epithelial cells [IECs] using organoid culture. Methods: IECs were isolated from mouse colon, and were cultured according to a method for a three-dimensional [3D] organoid culture...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28453727/endothelial-glycocalyx-breakdown-is-mediated-by-angiopoietin-2
#20
Alexander Lukasz, Carina Hillgruber, Hans Oberleithner, Kristina Kusche-Vihrog, Hermann Pavenstädt, Alexandros Rovas, Bettina Hesse, Tobias Goerge, Philipp Kümpers
Aims: The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage and adhesion in sepsis and vessel inflammation. Angiopoietin-2 (Angpt-2), an antagonist of the endothelium-stabilizing receptor Tie2 secreted by endothelial cells, promotes vascular permeability through cellular contraction and junctional disintegration. We hypothesized that Angpt-2 might also mediate the breakdown of the eGC...
May 1, 2017: Cardiovascular Research
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