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https://www.readbyqxmd.com/read/28919322/changes-in-vasodilation-following-myocardial-ischemia-reperfusion-in-rats
#1
Sarah Brøgger Kristiansen, Majid Sheykhzade, Lars Edvinsson, Kristian Agmund Haanes
BACKGROUND: Blockage of a coronary artery, usually caused by arteriosclerosis, can lead to life threatening acute myocardial infarction. Opening with PCI (percutaneous coronary intervention), may be lifesaving, but reperfusion might exacerbate the cellular damage, and changes in the endothelium are believed to be involved in this worsened outcome. AIM: The aim of the present study was to compare endothelial dependent and independent vasodilatory effect after experimental myocardial ischemia/reperfusion (I/R)...
September 14, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28904199/calcitonin-gene-related-peptide-induces-hiv-1-proteasomal-degradation-in-mucosal-langerhans-cells
#2
Morgane Bomsel, Yonatan Ganor
The neuro-immune dialogue between peripheral neurons and Langerhans cells (LCs) within mucosal epithelia protects against incoming pathogens. LCs rapidly internalize human immunodeficiency virus type 1 (HIV-1) upon its sexual transmission and then trans-infect CD4+ T-cells. We recently found that the neuropeptide calcitonin gene-related peptide (CGRP), secreted mucosally from peripheral neurons, inhibits LCs-mediated HIV-1 trans-infection. Herein, we investigated the mechanism of CGRP-induced inhibition, focusing on HIV-1 degradation in LCs and its interplay with trans-infection...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28898586/transcerebral-net-exchange-of-vasoactive-peptides-and-catecholamines-during-lipopolysaccharide-induced-systemic-inflammation-in-healthy-humans
#3
Ronan M G Berg, Sarah Taudorf, Damian Miles Bailey, Rasmus Holmboe Dahl, Carsten Lundby, Kirsten Møller
The systemic inflammatory response triggered by lipopolysaccharide (LPS) is associated with cerebral vasoconstriction, but the underlying mechanisms are unknown. We therefore examined whether a four-hour intravenous LPS infusion (0.3 ng kg<sup>-1</sup>) induces any changes in the transcerebral net exchange of the vasoactive peptides endothelin-1 (ET-1) and calcitonin-gene related peptide (CGRP) and catecholamines in human volunteers. Cerebral blood flow was measured by the Kety-Schmidt technique, and paired arterial-to-jugular venous blood samples were obtained for estimating the transcerebral exchange of ET-1, CGRP and catecholamines by the Fick principle in twelve volunteers before and after LPS...
September 12, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28898282/p2x3-receptor-involvement-in-endometriosis-pain-via-erk-signaling-pathway
#4
Shaojie Ding, Libo Zhu, Yonghong Tian, Tianhong Zhu, Xiufeng Huang, Xinmei Zhang
The purinergic receptor P2X ligand-gated ion channel 3 (P2X3) is crucially involved in peripheral nociceptive processes of somatic and visceral pain. Endometriosis pain is considered as a kind of inflammatory and neuropathic pain. However, whether P2X3 is involved in endometriosis pain has not been reported up to date. Here, we aimed to determine whether P2X3 expression in endometriotic lesions is involved in endometriosis pain, which is regulated by inflammatory mediators through extracellular regulated protein kinases (ERK) signalling pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28893229/neuroimmune-expression-in-hip-osteoarthritis-a-systematic-review
#5
Manuel Ribeiro da Silva, Daniela Linhares, Daniel Marques Vasconcelos, Cecilia Juliana Alves, Nuno Neves, Gilberto Costa, Meriem Lamghari
BACKGROUND: Neuroimmune axis is central in the physiopathology of hip osteoarthritis (OA), but its specific pathways are still unclear. This systematic review aims to assess the nervous and immune system profile of patients with hip osteoarthritis (OA) when compared to healthy controls. METHODS: A systematic review followed PRISMA guidelines was conducted. A two-step selection process was completed, and from 609 references 17 were included. The inclusion criteria were: original articles on adult patients with hip OA, with assessment of neuroimmune expression...
September 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28892747/calcitonin-gene-related-peptide-exerts-anti-inflammatory-property-through-regulating-murine-macrophages-polarization-in-vitro
#6
Jia-Xi Duan, Yong Zhou, Ai-Yuan Zhou, Xin-Xin Guan, Tian Liu, Hui-Hui Yang, Hui Xie, Ping Chen
Acute lung injury (ALI) is a condition resulting from direct or indirect lung injury associated with high mortality and morbidity. The phenotype of macrophages in lung contributes to the pathological progress of ALI. Calcitonin gene-related peptide (CGRP) is one of the most abundant neuropeptides in lung, and attenuates lipopolysaccharide (LPS)-induced ALI in rats. However, the exact effect of CGRP on the activation of macrophages remains unknown. Here we investigate the effect of CGRP on the macrophages activation and inflammation in murine macrophages in vitro...
September 8, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28891864/photosensitization-of-trpa1-and-trpv1-by-7-dehydrocholesterol-implications-for-the-smith-lemli-opitz-syndrome
#7
Alexandru Babes, Cosmin I Ciotu, Tal Hoffmann, Tatjana I Kichko, Tudor Selescu, Cristian Neacsu, Susanne K Sauer, Peter W Reeh, Michael J M Fischer
Loss of function mutations in the enzyme 7-dehydrocholesterol reductase are responsible for the Smith-Lemli-Opitz syndrome, in which 7-dehydrocholesterol (7-DHC) levels are markedly increased in the plasma and tissues of patients. This increase in 7-DHC is probably associated with the painful and itchy photosensitivity reported by the large majority of Smith-Lemli-Opitz syndrome patients. In order to identify the molecular targets involved in the activation and photosensitization of primary afferents by 7-DHC we focused on TRPA1 and TRPV1, two ion channels expressed in nociceptive nerve endings and previously shown to respond to ultraviolet and visible light under pathophysiological circumstances...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28886662/comment-on-relationship-between-serum-levels-of-vip-but-not-of-cgrp-and-cranial-autonomic-parasympathetic-symptoms-a-study-in-chronic-migraine-patients
#8
Hyun Jin Min, Kyung Soo Kim
No abstract text is available yet for this article.
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28884411/role-of-calcitonin-gene-related-peptide-in-energy-metabolism
#9
REVIEW
William Gustavo Lima, Gleuber Henrique Marques-Oliveira, Thaís Marques da Silva, Valéria Ernestânia Chaves
PURPOSE: Calcitonin gene-related peptide (CGRP) is a neuropeptide produced by alternative tissue-specific splicing of the primary transcript of the CALC genes. CGRP is widely distributed in the central and peripheral nervous system, as well as in several organs and tissues. The presence of CGRP in the liver and brown and white adipose tissue suggests an effect of this neuropeptide on regulation of energy homeostasis. METHODS: In this review, we summarize the current knowledge of the effect of CGRP on the control of energy metabolism, primarily focusing on food intake, thermoregulation and lipid metabolism in adipose tissue, liver and muscle...
September 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28884307/the-role-of-the-transient-receptor-potential-ankyrin-type-1-trpa1-channel-in-migraine-pain-evaluation-in-an-animal-model
#10
Chiara Demartini, Cristina Tassorelli, Anna Maria Zanaboni, Germana Tonsi, Oscar Francesconi, Cristina Nativi, Rosaria Greco
BACKGROUND: Clinical and experimental studies have pointed to the possible involvement of the transient receptor potential ankyrin type-1 (TRPA1) channels in migraine pain. In this study, we aimed to further investigate the role of these channels in an animal model of migraine using a novel TRPA1 antagonist, ADM_12, as a probe. METHODS: The effects of ADM_12 on nitroglycerin-induced hyperalgesia at the trigeminal level were investigated in male rats using the quantification of nocifensive behavior in the orofacial formalin test...
September 7, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28883884/itraq-based-quantitative-proteomics-analysis-of-the-protective-effect-of-yinchenwuling-powder-on-hyperlipidemic-rats
#11
Zheyu Zhang, Wenbo Wang, Ling Jin, Xin Cao, Gonghui Jian, Ning Wu, Xia Xu, Ye Yao, Dongsheng Wang
Yinchenwuling powder (YCL) is an effective traditional Chinese medicine formula to modulate lipid levels. In this study, we established hyperlipidemic rat models and treated them with YCL. The serum concentrations of lipid, malondialdehyde (MDA), endothelin-1 (ET-1), and calcitonin gene-related peptide (CGRP) were measured. Adventitia-free vascular proteins between hyperlipidemic rats and YCL-treated rats were identified using iTRAQ-based quantitative proteomics research approach. Proteins with 1.3-fold difference were analyzed through bioinformatics, and proteomic results were verified by Western blot...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28874973/inhibiting-vascular-endothelial-growth-factor-in-injured-intervertebral-discs-attenuates-pain-related-neuropeptide-expression-in-dorsal-root-ganglia-in-rats
#12
Jun Sato, Kazuhide Inage, Masayuki Miyagi, Yoshihiro Sakuma, Kazuyo Yamauchi, Masao Koda, Takeo Furuya, Junichi Nakamura, Miyako Suzuki, Go Kubota, Yasuhiro Oikawa, Takeshi Sainoh, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Kazuhisa Takahashi, Seiji Ohtori, Sumihisa Orita
STUDY DESIGN: An experimental animal study. PURPOSE: To evaluate effects of anti-vascular endothelial growth factor (VEGF) on the content and distribution of the calcitonin gene-related peptide (CGRP) in the dorsal ganglia in a rat model. OVERVIEW OF LITERATURE: Increased expression of VEGF in degenerative disc disease increases the levels of inflammatory cytokines and nerve ingrowth into the damaged discs. In animal models, increased levels of VEGF can persist for up to 2 weeks after an injury...
August 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28874746/rgma-inhibition-with-human-monoclonal-antibodies-promotes-regeneration-plasticity-and-repair-and-attenuates-neuropathic-pain-after-spinal-cord-injury
#13
Andrea J Mothe, Nardos G Tassew, Alirezha P Shabanzadeh, Romeo Penheiro, Robin J Vigouroux, Lili Huang, Christine Grinnell, Yi-Fang Cui, Emma Fung, Philippe P Monnier, Bernhard K Mueller, Charles H Tator
Traumatic spinal cord injury (SCI) causes a cascade of degenerative events including cell death, axonal damage, and the upregulation of inhibitory molecules which prevent regeneration and limit recovery. Repulsive guidance molecule A (RGMa) is a potent neurite growth inhibitor in the central nervous system, exerting its repulsive activity by binding the Neogenin receptor. Here, we show for the first time that inhibitory RGMa is markedly upregulated in multiple cell types after clinically relevant impact-compression SCI in rats, and importantly, also in the injured human spinal cord...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28868184/multiple-endocrine-neoplasia-2b-differential-increase-in-enteric-nerve-subgroups-in-muscle-and-mucosa
#14
John M Hutson, Pam J Farmer, Cristal J Peck, Chung W Chow, Bridget R Southwell
Multiple endocrine neoplasia 2B (MEN2B) is a rare syndrome caused by an activating mutation of the RET gene, leading to enteric gangliomatosis. This child presented with constipation at 1-mo old, was diagnosed with MEN2B by rectal biopsy at 4 mo, had thyroidectomy at 9 mo and a colectomy at 4 years. We studied the extent of neuronal and nerve fibre proliferation and which classes of enteric nerves are affected by examining the colon with multiple neuronal antibodies. Resected transverse colon was fixed, frozen, sectioned and processed for fluorescence immunohistochemistry labelling with antibodies against TUJ1, Hu, ChAT, NOS, VIP, SP and CGRP and cKit...
August 15, 2017: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/28867800/ciguatoxins-evoke-potent-cgrp-release-by-activation-of-voltage-gated-sodium-channel-subtypes-nav1-9-nav1-7-and-nav1-1
#15
Filip Touska, Simon Sattler, Philipp Malsch, Richard J Lewis, Peter W Reeh, Katharina Zimmermann
Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus. Although CTXs are known as the most potent mammalian sodium channel activator toxins, the etiology of many of its neurosensory symptoms remains unresolved. We recently described that local application of 1 nM Pacific Ciguatoxin-1 (P-CTX-1) into the skin of human subjects induces a long-lasting, painful axon reflex flare and that CTXs are particularly effective in releasing calcitonin-gene related peptide (CGRP) from nerve terminals...
August 30, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28866875/substance-p-and-calcitonin-gene-related-peptide-in-the-glands-of-external-auditory-canal-skin
#16
Yong Joo Yoon, Jin Yoon, Eun Jung Lee, Jong Seung Kim
Objectives.: The earwax (cerumen) that covers external auditory canal (EAC) skin contains a mixture of ceruminous and sebaceous gland substances, such as lipids, peptides, and proteins. The components secreted from the ceruminous gland that is a modified sweat gland form cerumen and contain several antimicrobial factors. Since substance P (SP) and calcitonin gene-related peptide (CGRP), known as a secretagogue, have been found in sweat glands, our purpose was to determine the expression of SP and CGRP in the glands of EAC skin...
September 5, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28865235/effect-of-electro-acupuncture-on-neuroplasticity-of-spinal-cord-transected-rats
#17
Xuyang Wang, Shiming Ju, Shiwen Chen, Wenwei Gao, Jun Ding, Gan Wang, Heli Cao, Hengli Tian, Xiaoli Li
BACKGROUND This study aimed to evaluate the effects of electro-acupuncture (EA) on neuroplasticity associated with the expressions of neurotrophic factors (NTFs) and their receptors in rats subjected to spinal cord transection (SCT). MATERIAL AND METHODS A total of 144 rats were randomly divided into 3 groups (n=48 per group): sham-operated group, SCT group, and EA (electro-acupuncture) group. Rats in SCT and EA groups received spinal cord transection at T10-T11 vertebral levels. Then, EA group rats received EA treatment...
September 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28865207/immunohistochemical-characterization-of-the-jugular-superior-vagal-ganglion-in-the-pig
#18
W Sienkiewicz, A Dudek, A Zacharko-Siembida, M Marszałek
The study was carried out on three 4-month old female pigs. All the animals were deeply anesthetized and transcardially perfused with 4% buffered paraformaldehyde (pH 7.4). Left and right superior vagal ganglia (SVG) were collected and processed for immunofluorescence labeling method. The preparations were examined under a Zeiss LSM 710 confocal microscope equipped with adequate filter block. Neurons forming SVG were round or oval in shape with a round nucleus in the center. The majority of them (52%) were medium (M) (31-50 μm in diameter) while 7% and 41% were small (S) (up to 30μm in diameter) or large (L) (above 50 μm in diameter) in size, respectively...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28862769/histamine-and-migraine
#19
Hsiangkuo Yuan, Stephen D Silberstein
BACKGROUND: Histamine is an ancient "tissue amine" preceding multicellular organisms. In the central nervous system (CNS), its fibers originate solely from the tuberomammillary nucleus and travel throughout the brain. It is mainly responsible for wakefulness, energy homeostasis, and memory consolidation. Recently, several studies suggest a potential role of histamine in migraine pathogenesis and management. METHODS: Narrative review of current literature regarding histamine and migraine...
September 1, 2017: Headache
https://www.readbyqxmd.com/read/28862758/fremanezumab-as-add-on-treatment-for-patients-treated-with-other-migraine-preventive-medicines
#20
Joshua M Cohen, David W Dodick, Ronghua Yang, Lawrence C Newman, Thomas Li, Ernesto Aycardi, Marcelo E Bigal
BACKGROUND: Fremanezumab (formerly TEV-48125) is a monoclonal antibody directed against calcitonin-gene-related peptide (CGRP), a validated target for migraine preventive therapy. In two previous phase 2 studies, fremanezumab administered once every 28 days for 12 weeks was found to be effective and safe as a preventive treatment for patients suffering from episodic migraine (EM) and chronic migraine (CM). OBJECTIVE: To evaluate the efficacy and safety of fremanezumab as an add-on preventive therapy in individuals with EM and CM who are on stable doses of preventive migraine medications...
September 1, 2017: Headache
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