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https://www.readbyqxmd.com/read/29772080/substance-p-and-calcitonin-gene-related-peptide-expression-in-human-periodontal-ligament-after-root-canal-preparation-with-reciproc-blue-waveone-gold-xp-endoshaper-and-hand-files
#1
J Caviedes-Bucheli, N Rios-Osorio, M Rey-Rojas, F Laguna-Rivero, M M Azuero-Holguin, L E Diaz, H Curtidor, J J Castaneda-Ramirez, H R Munoz
AIM: To quantify the Substance P (SP) and Calcitonin gene-related peptide (CGRP) expression in healthy human periodontal ligament from premolars after root canal preparation with Reciproc Blue, WaveOne Gold, XP EndoShaper and hand files. METHODOLOGY: Fifty human periodontal ligament samples were obtained from healthy mandibular premolars where extraction was indicated for orthodontic reasons. Prior to extraction, 40 of these premolars were equally divided into four groups, and root canals were prepared using four different systems: Reciproc Blue, WaveOne Gold, XP EndoShaper, and a hand instrumentation technique...
May 17, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29754819/blocking-neuronal-signaling-to-immune-cells-treats-streptococcal-invasive-infection
#2
Felipe A Pinho-Ribeiro, Buket Baddal, Rianne Haarsma, Maghnus O'Seaghdha, Nicole J Yang, Kimbria J Blake, Makayla Portley, Waldiceu A Verri, James B Dale, Michael R Wessels, Isaac M Chiu
The nervous system, the immune system, and microbial pathogens interact closely at barrier tissues. Here, we find that a bacterial pathogen, Streptococcus pyogenes, hijacks pain and neuronal regulation of the immune response to promote bacterial survival. Necrotizing fasciitis is a life-threatening soft tissue infection in which "pain is out of proportion" to early physical manifestations. We find that S. pyogenes, the leading cause of necrotizing fasciitis, secretes streptolysin S (SLS) to directly activate nociceptor neurons and produce pain during infection...
May 7, 2018: Cell
https://www.readbyqxmd.com/read/29752991/cerebrolysin-attenuates-hyperalgesia-photophobia-and-neuroinflammation-in-a-nitroglycerin-induced-migraine-model-in-rats
#3
Javad Mahmoudi, Gisou Mohaddes, Marjan Erfani, Saeed Sadigh-Eteghad, Pouran Karimi, Mojgan Rajabi, Siamak Reyhani-Rad, Fereshteh Farajdokht
Chronic migraine dramatically affects the quality of life in the migraineurs. This study examined the effect of chronic cerebrolysin (CBL) treatment on the migraine-associated symptoms in a rat model of migraine. Experiments were carried out on 8 weeks, male Wistar rats. Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9. CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days. Mechanical and thermal withdrawal thresholds of the hind paw were examined by von Frey hairs and hot plate, respectively...
May 9, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29745819/crosstalk-between-neuropeptides-sp-and-cgrp-in-regulation-of-bmp2-induced-bone-differentiation
#4
Ceren Tuzmen, Phil G Campbell
AIM OF THE STUDY: The peripheral nervous system is involved in regulation of bone metabolism via sensory and sympathetic innervation. Substance P (SP) and calcitonin gene-related peptide (CGRP) are two sensory neuropeptides that have been associated with regulation of osteogenic differentiation. However, the interaction between SP and CGRP both with each other and the bone morphogenetic protein 2 (BMP2) in regulation of osteogenic differentiation has not been studied. Therefore, the aim of this study was to investigate the interaction between SP and CGRP on BMP2-induced bone differentiation using model progenitor cells...
December 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29741760/involvement-of-cgrp-rcp-in-the-caveolin-1-erk1-2-signal-pathway-in-the-static-pressure-induced-proliferation-of-vascular-smooth-muscle-cells
#5
Feng Guo, Li Yang, Jingfei Luo, Haiyan Quan, Zhen Wang, Hongyan Peng, Chenliang Hong, Jie Li, Zhisheng Jiang, Liang Zhang, Xuping Qin
Previous study suggested that the receptor component protein (RCP), one of the components of calcitonin gene-related peptide (CGRP) receptor, plays a multiple role in the cellular signal transduction. The study was designed to investigate whether or not the RCP involved in the regulation of caveolin-1/extracellular signal-regulated kinases-1 and -2 (ERK1/2) signal pathway in the vascular smooth muscle cells (VSMCs) proliferation induced by static pressure. Mouse-derived VSMCs line A10 (A10 VSMCs) was served as project in this experiment...
May 9, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29741434/effects-of-oxaliplatin-treatment-on-the-myenteric-plexus-innervation-and-glia-in-the-murine-distal-colon
#6
Vanesa Stojanovska, Rachel M McQuade, Sarah Miller, Kulmira Nurgali
Oxaliplatin (platinum-based chemotherapeutic agent) is a first-line treatment of colorectal malignancies; its use associates with peripheral neuropathies and gastrointestinal side effects. These gastrointestinal dysfunctions might be due to toxic effects of oxaliplatin on the intestinal innervation and glia. Male Balb/c mice received intraperitoneal injections of sterile water or oxaliplatin (3 mg/kg/d) triweekly for 2 weeks. Colon tissues were collected for immunohistochemical assessment at day 14. The density of sensory, adrenergic, and cholinergic nerve fibers labeled with calcitonin gene-related peptide (CGRP), tyrosine hydroxylase (TH), and vesicular acetylcholine transporter (VAChT), respectively, was assessed within the myenteric plexus of the distal colon...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29740961/expression-of-regeneration-associated-proteins-in-primary-sensory-neurons-and-regenerating-axons-after-nerve-injury-an-overview
#7
Petr Dubový, Ilona Klusáková, Ivana Hradilová-Svíženská, Marek Joukal
Peripheral nerve injury results in profound alterations of the affected neurons resulting from the interplay between intrinsic and extrinsic molecular events. Restarting the neuronal regenerative program is an important prerequisite for functional recovery of the injured peripheral nerve. The primary sensory neurons with their cell bodies in the dorsal root ganglia provide a useful in vivo and in vitro model for studying the mechanisms that regulate intrinsic neuronal regeneration capacity following axotomy...
May 8, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29734141/innervation-of-the-human-incisive-papilla-comparison-with-other-oral-regions
#8
Chiaki Endo, Tadasu Sato, Takehiro Yajima, Kaoru Igarashi, Hiroyuki Ichikawa
Immunohistochemistry for several neurochemical substances was performed on the human incisive papilla and other oral structures. Sodium channel alpha subunit 7 (SCN7A) protein-immunoreactive (IR) Schwann cells and protein gene product 9.5 (PGP 9.5)-IR nerve fibers made nerve plexuses beneath the epithelium of the palate, including the incisive papilla, tongue, and lip. SCN7A immunoreactivity could also be detected in lamellated and nonlamellated capsules of corpuscle endings. Lamellated SCN7A-IR corpuscle endings were mostly restricted to the mucous and cutaneous lips...
May 7, 2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29732591/differential-conduction-and-cgrp-release-in-visceral-versus-cutaneous-peripheral-nerves-in-the-mouse
#9
Roberto De Col, Karl Messlinger, Tali Hoffmann
Cutaneous afferent nerves convey sensory information from the external, visceral nerves from the internal environment. The saphenous nerve arising from lumbar dorsal root ganglia and the vagus nerve originating in the nodosum ganglia are prototypic examples of such cutaneous and visceral nerves. Despite a common sensory role, these two nerves have distinct embryonic origin and vary in neuropeptide expression. Because of their distinct physiological roles, it is plausible that they differ also in conductive properties...
May 6, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29730242/potentiation-of-capsaicin-induced-neurogenic-inflammation-by-5-ht7-receptors-in-the-rat-hind-paw-involvement-of-calcitonin-gen-related-peptide
#10
Luis D Arreola-Peralta, Frida Altamirano-Reyna, Deni M Galindo-González, Jessica G Solis-Anguiano, Enza Lacivita, Marcello Leopoldo, José A Terrón
A decrease in the activation threshold of primary sensory neurons to transient receptor potential V1 (TRPV1) stimulation by serotonin 5-HT7 receptors has been reported but no confirmation if this might translate into facilitation of neurogenic inflammation has been provided. We analysed the modulation of capsaicin (CAP)-induced neurogenic inflammation in the rat hind paw by the selective 5-HT7 receptor agonist, LP-44, and the involvement of calcitonin gen-related peptide (CGRP) in this effect. Animals received intra-plantar injections (30 μl) of vehicle, CAP (0...
May 3, 2018: Peptides
https://www.readbyqxmd.com/read/29722303/harnessing-migraines-for-neural-regeneration
#11
REVIEW
Jonathan M Borkum
The success of naturalistic or therapeutic neuroregeneration likely depends on an internal milieu that facilitates the survival, proliferation, migration, and differentiation of stem cells and their assimilation into neural networks. Migraine attacks are an integrated sequence of physiological processes that may protect the brain from oxidative stress by releasing growth factors, suppressing apoptosis, stimulating neurogenesis, encouraging mitochondrial biogenesis, reducing the production of oxidants, and upregulating antioxidant defenses...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29722276/sustained-reductions-in-migraine-days-moderate-to-severe-headache-days-and-days-with-acute-medication-use-for-hfem-and-cm-patients-taking-fremanezumab-post-hoc-analyses-from-phase-2-trials
#12
Rashmi B Halker Singh, Ernesto Aycardi, Marcelo E Bigal, Pippa S Loupe, Mirna McDonald, David W Dodick
Background In phase 2 and 3 studies, fremanezumab, a monoclonal CGRP antibody, was an effective preventive treatment for high-frequency episodic migraine (HFEM) and chronic migraine (CM). Objective Post-hoc analyses evaluated population-wise 50%, 75% and 100% responder rates, and the extent to which individual responders sustained a 50%, 75% and 100% reduction in migraine days, moderate-to-severe (M/S) headache days and days of acute medication use during all three treatment months of the fremanezumab phase 2 studies...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29719223/the-transient-receptor-potential-ankyrin-type-1-plays-a-critical-role-in-cortical-spreading-depression
#13
Liwen Jiang, Yan Wang, Yuewei Xu, Dongqing Ma, Minyan Wang
The transient receptor potential ankyrin type-1 (TRPA1) channels have been proposed as a potential target for migraine therapy. Yet the role of cortical TRPA1 channels in migraine mechanism has not been fully understood. Cortical spreading depression (CSD) is known as an underlying cause of migraine aura. The aim of this study is to investigate if cortical TRPA1 activity is required for CSD genesis and propagation. A mouse brain slice CSD model with intrinsic optical imaging was applied for TRPA1 signaling pharmacology...
April 29, 2018: Neuroscience
https://www.readbyqxmd.com/read/29715519/oxidative-stress-contributes-to-fracture-cast-induced-inflammation-and-pain-in-a-rat-model-of-complex-regional-pain-syndrome
#14
Tian-Zhi Guo, Tzuping Wei, Ting-Ting Huang, Wade S Kingery, John David Clark
Clinical evidence suggests vitamin C (Vit C) may protect against the development of complex regional pain syndrome (CRPS) after fracture and/or surgery. Tibia fracture followed by 4 weeks cast immobilization (fracture/cast) in rats results in nociceptive, vascular, and bone changes resembling clinical CRPS. In the present study, fracture/cast rats were treated with the oxidative stress inhibitors Vit C, N-acetyl cysteine (NAC) or 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL) to examine their effects on CRPS-related nociceptive and vascular changes...
April 28, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29713744/skin-neurogenic-inflammation
#15
REVIEW
Jae Eun Choi, Anna Di Nardo
The epidermis closely interacts with nerve endings, and both epidermis and nerves produce substances for mutual sustenance. Neuropeptides, like substance P (SP) and calcitonin gene-related protein (CGRP), are produced by sensory nerves in the dermis; they induce mast cells to release vasoactive amines that facilitate infiltration of neutrophils and T cells. Some receptors are more important than others in the generation of itch. The Mas-related G protein-coupled receptors (Mrgpr) family as well as transient receptor potential ankyrin 1 (TRPA1) and protease activated receptor 2(Par2) have important roles in itch and inflammation...
April 30, 2018: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29709471/mm9_circ_009056-enhances-osteogenesis-by-targeting-bmp7-via-cgrp-mediated-mir-22-3p
#16
Caijuan Wu, Zhichao Zheng, Wen Ren, Tian Deng, Yuanjing Li, Lan Yang, Jingwen Wu, Zhu Huang, Zhengmao Li, Lvhua Guo
Circular RNAs (circRNAs) are noncoding RNAs that can function as miRNA sponges, post-transcriptionally regulating the expression of genes. Here, we report a novel positive function of mm9_circ_009056 during osteogenesis in regulating bone morphogenetic protein 7 (BMP7) through miR-22-3p. First, we found that calcitonin gene-related peptide (CGRP) had great osteogenesis function on MC3T3 cells. Then aberrant expression of mm9_circ_009056 were confirmed in CGRP-induced cells. Furthermore, the expression of mm9_circ_009056 was up-regulated in the CGRP-induced cells, whereas miR-22-3p was obviously decreased...
April 27, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29706124/sensorimotor-activity-partially-ameliorates-pain-and-reduces-nociceptive-fiber-density-in-the-chronically-injured-spinal-cord
#17
Christopher Sliwinski, Timo A Nees, Radhika Puttagunta, Norbert Weidner, Armin Blesch
A large proportion of patients suffering from spinal cord injury (SCI) develop chronic central neuropathic pain. Previously, we and others have shown that sensorimotor training early after SCI can prevent the development of mechanical allodynia. To determine whether training initiated in the subchronic/chronic phase remains effective, correlates of below level neuropathic pain were analyzed in the hindpaws 5-10 weeks after a moderate T11 contusion SCI (50 kDyn) in adult female C57BL/6 mice. Comparing SCI and sham mice 5 weeks post-injury, about 80% of injured animals developed mechanical hypersensitivity to light mechanical stimuli, whereas testing of noxious stimuli revealed hypo-responsiveness...
April 28, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29703377/the-parabrachial-nucleus-cgrp-neurons-function-as-a-general-alarm
#18
REVIEW
Richard D Palmiter
The parabrachial nucleus (PBN), which is located in the pons and is dissected by one of the major cerebellar output tracks, is known to relay sensory information (visceral malaise, taste, temperature, pain, itch) to forebrain structures including the thalamus, hypothalamus, and extended amygdala. The availability of mouse lines expressing Cre recombinase selectively in subsets of PBN neurons and viruses for Cre-dependent gene expression is beginning to reveal the connectivity and functions of PBN component neurons...
May 2018: Trends in Neurosciences
https://www.readbyqxmd.com/read/29697155/foreword-the-cgrp-pathway-and-migraine-prevention-reducing-the-burden-of-disease
#19
Philip R Holland
No abstract text is available yet for this article.
May 2018: Headache
https://www.readbyqxmd.com/read/29697153/the-cgrp-pathway-in-migraine-as-a-viable-target-for-therapies
#20
Lars Edvinsson
The neuropeptide calcitonin gene-related peptide is well established as a key player in the pathogenesis of migraine. Clinical studies show calcitonin gene-related peptide levels correlate with migraine attacks, and decreases in this neuropeptide can indicate antimigraine therapy effectiveness. Research has revealed a wide distribution of expression sites for calcitonin gene-related peptide in the central and peripheral nervous system. Of these, the calcitonin gene-related peptide receptor, which binds calcitonin gene-related peptide with high affinity, has attracted growing interest as a viable target for antimigraine therapies...
May 2018: Headache
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