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https://www.readbyqxmd.com/read/28532202/experiences-of-establishing-an-academic-early-phase-clinical-trials-unit
#1
Sarah R Brown, Debbie Sherratt, Gill Booth, Julia Brown, Fiona Collinson, Walter Gregory, Louise Flanagan
BACKGROUND: Early phase trials are essential in drug development, determining appropriate dose levels and assessing preliminary activity. These trials are undertaken by industry and academia, with increasing collaborations between the two. There is pressure to perform these trials quickly, safely, and robustly. However, there are inherent differences between developing and managing early phase, compared to late phase, drug trials. This article describes an approach to establishing an academically led early phase trial portfolio, highlighting lessons learned and sharing experiences...
May 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28530414/quality-charters-or-quality-members-a-control-theory-perspective-on-team-charters-and-team-performance
#2
Stephen H Courtright, Brian W McCormick, Sal Mistry, Jiexin Wang
Though prevalent in practice, team charters have only recently received scholarly attention. However, most of this work has been relatively devoid of theory, and consequently, key questions about why and under what conditions team charter quality affects team performance remain unanswered. To address these gaps, we draw on macro organizational control theory to propose that team charter quality serves as a team-level "behavior" control mechanism that builds task cohesion through a structured exercise. We then juxtapose team charter quality with an "input" team control mechanism that influences the emergence of task cohesion more organically: team conscientiousness...
May 22, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28526402/outpatient-antibiotic-stewardship-interventions-and-opportunities
#3
Erica L Dobson, Michael E Klepser, Jason M Pogue, Matthew J Labreche, Alex J Adams, Timothy P Gauthier, R Brigg Turner, Christy P Su, David M Jacobs, Katie J Suda
Improving the use of antibiotics across the continuum of care is a national priority. Data outlining the misuse of antibiotics in the outpatient setting justify the expansion of antibiotic stewardship programs (ASPs) into this health care setting; however, best practices for outpatient antibiotic stewardship (AS) are not yet defined. In a companion article, we focused on recommendations to overcome challenges related to the implementation of an outpatient ASP (e.g., building the AS team and defining program metrics)...
May 16, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28521799/what-are-the-differences-among-occupational-groups-related-to-their-palliative-care-specific-educational-needs-and-intensity-of-interprofessional-collaboration-in-long-term-care-homes
#4
S Kaasalainen, T Sussman, M Bui, N Akhtar-Danesh, R D Laporte, L McCleary, A Wickson Griffiths, K Brazil, D Parker, V Dal Bello-Haas, A Papaioannou, J O'Leary
BACKGROUND: The purpose of this study was to compare the differences across occupational groups related to their end-of-life care-specific educational needs and reported intensity of interprofessional collaboration in long-term care (LTC) homes. METHODS: A cross-sectional survey, based on two questionnaires, was administered at four LTC homes in Ontario, Canada using a modified Dilman's approach. The first questionnaire, End of Life Professional Caregiver Survey, included three domains: patients and family-centered communication, cultural and ethical values, effective care delivery...
May 18, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28521717/analysis-of-site-heterogeneity-and-hiv-outcomes-across-rural-and-urban-study-sites-in-phidisa-ii-a-multi-site-randomized-controlled-antiretroviral-treatment-trial-in-a-south-african-military-cohort
#5
John Steytler, Pamela A Shaw, Alice K Pau, Paul Khabo, Gyan Joshi, Pieter Oelofse
BACKGROUND: Clinical trials frequently enroll subjects from different study sites. Few such studies provide analysis by individual site. Between 2004-2007, the South African Military Health System (SAMHS) established 6 research sites (3 urban, 3 rural) to build capacity for clinical research and HIV care. We explore differences in clinical, virologic and CD4 outcomes by site in the context of a randomized controlled trial. METHODS: Phidisa-II is the first randomised controlled trial conducted in the South African military setting, which compared 4 antiretroviral regimens in treatment-naïve advanced HIV subjects...
May 17, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28514912/team-sponsors-in-community-based-health-leadership-programs
#6
Tracy Enright Patterson, Donna R Dinkin, Heather Champion
Purpose The purpose of this article is to share the lessons learned about the role of team sponsors in action-learning teams as part of community-based health leadership development programs. Design/methodology/approach This case study uses program survey results from fellow participants, action learning coaches and team sponsors to understand the value of sponsors to the teams, the roles they most often filled and the challenges they faced as team sponsors. Findings The extent to which the sponsors were perceived as having contributed to the work of the action learning teams varied greatly from team to team...
May 2, 2017: Leadership in Health Services
https://www.readbyqxmd.com/read/28514473/effective-team-practices-interprofessional-contributions-to-communication-issues-with-a-parent-s-perspective
#7
Karena Cooper-Duffy, Kerri Eaker
Purpose: This clinical focus article contains a detailed description of how to build effective teams that use interprofessional collaborative practice (IPCP) with special-education professionals, speech-language pathologists, and families of children with severe disabilities. Method: This clinical focus article provides information on using the essential elements of team building and IPCP to provide quality care to families who have children with severe disabilities...
May 17, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28511261/current-practice-and-the-future-of-deep-brain-stimulation-therapy-in-parkinson-s-disease
#8
Leonardo Almeida, Wissam Deeb, Chauncey Spears, Enrico Opri, Rene Molina, Daniel Martinez-Ramirez, Aysegul Gunduz, Christopher W Hess, Michael S Okun
Deep brain stimulation (DBS) is an effective therapy for Parkinson's disease patients experiencing motor fluctuations, medication-resistant tremor, and/or dyskinesia. Currently, the subthalamic nucleus and the globus pallidus internus are the two most widely used targets, with individual advantages and disadvantages influencing patient selection. Potential DBS patients are selected using the few existing guidelines and the available DBS literature, and many centers employ an interdisciplinary team review of the individual's risk-benefit profile...
April 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/28506957/computer-administered-safety-planning-for-individuals-at-risk-for-suicide-development-and-usability-testing
#9
Edwin D Boudreaux, Gregory K Brown, Barbara Stanley, Rajani S Sadasivam, Carlos A Camargo, Ivan W Miller
BACKGROUND: Safety planning is a brief intervention that has become an accepted practice in many clinical settings to help prevent suicide. Even though it is quick compared to other approaches, it frequently requires 20 min or more to complete, which can impede adoption. A self-administered, Web-based safety planning application could potentially reduce clinician time, help promote standardization and quality, and provide enhanced ability to share the created plan. OBJECTIVE: The aim of this study was to design, build, and test the usability of a Web-based, self-administered safety planning application...
May 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28502847/the-role-for-cardiologists-in-stroke-intervention
#10
REVIEW
Richard R Heuser
Even though cardiovascular disease (CVD) is still the leading cause of death in the United States, stroke is the second leading of global cause of death behind CVD . In the 21st Century, less than 40% of overall stroke patients are discharged to home and almost 25% of Medicare beneficiaries do not survive 90days. In spite of the fact that tissue plasminogen activator (TPA) has been approved for stroke care for 20years, only .75% of annual strokes are actually treated with intravenous (IV) TPA. Similar to how interventional cardiologists evolved from IV to catheter mechanical treatment for acute myocardial infarctions (AMI) over 30years ago, over the last few years, neurointerventionists now perform endovascular stroke therapy in many of these patients using stent retrievers...
May 11, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28498195/building-health-system-capacity-through-implementation-research-experience-of-inspire-a-multi-country-pmtct-implementation-research-project
#11
Morkor Newman Owiredu, Nita B Bellare, Christine C Chakanyuka Musanhu, Taiwo A Oyelade, Ellen M Thom, Francoise Bigirimana, Chukwuma Anyaike, Michael T Eliya, Angela Mushavi, Eugene A Nyarko, David O Okello, Felicitas R Zawaira
BACKGROUND: The INSPIRE-Integrating and Scaling Up PMTCT through Implementation REsearch-initiative was established as a model partnership of national prevention of mother-to-child transmission of HIV (PMTCT) implementation research in 3 high HIV burden countries-Malawi, Nigeria, and Zimbabwe. INSPIRE aimed to link local research groups with Ministries of Health (MOH), build local research capacity, and demonstrate that implementation research may contribute to improving health care delivery and respond to program challenges...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28498004/a-sequential-implementation-model-for-workforce-development-a-case-study-of-medical-residency-training-for-substance-use-concerns
#12
Patricia S O'Sullivan, Patrick Yuan, Derek D Satre, Maria Wamsley, Jason Satterfield
PROBLEM: In graduate medical education, residency programs are often educationally isolated from each other, with varying needs and patient populations, so strategies are needed when attempting to implement training in evidence-based practices across multiple residencies. INTERVENTION: Using implementation science as a guide, we adapted a community development model to sequentially implement an evidence-based intervention, Screening, Brief Intervention, and Referral to Treatment (SBIRT) for alcohol and drug use problems, across internal medicine, pediatrics, emergency medicine, psychiatry, and obstetrics and gynecology residency programs...
May 12, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28496275/qualitative-analysis-of-student-perceptions-comparing-team-based-learning-and-traditional-lecture-in-a-pharmacotherapeutics-course
#13
Tami L Remington, Barry E Bleske, Tracy Bartholomew, Michael P Dorsch, Sally K Guthrie, Kristin C Klein, Jeffrey M Tingen, Trisha D Wells
Objective. To qualitatively compare students' attitudes and perceptions regarding team-based learning (TBL) and lecture. Design. Students were exposed to TBL and lecture in an elective pharmacotherapeutics course in a randomized, prospective, cross-over design. After completing the course, students provided their attitudes and perceptions through a written self-reflection and narrative questions on the end-of-course evaluation. Student responses were reviewed using a grounded theory coding method. Assessment...
April 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28494624/an-overview-of-the-performance-improvement-initiatives-by-the-ministry-of-health-in-the-kingdom-of-saudi-arabia
#14
Mazen Hassanain
Saudi Arabia's Ministry of Health (MOH) use corporate performance improvement methodologies to develop and implement performance improvement initiatives designed to continue building on the Ministry's vision of transforming hospital operations and instituting a culture of quality and performance focused on the "patient first" principle. We evaluated the feasibility of setting up a performance improvement unit (PIU) within the MOH to apply the principles of Lean Six Sigma and to change management methodologies...
January 1, 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/28487349/patient-centred-innovations-for-persons-with-multimorbidity-funded-evaluation-protocol
#15
Moira Stewart, Martin Fortin
BACKGROUND: The high prevalence of multimorbidity necessitates rethinking of the health care system. The overarching goal of the Patient-Centred Innovations for Persons with Multimorbidity program is to build on existing structures and find and evaluate patient-centred innovations relevant to multimorbidity. METHODS: We describe the protocol for a proposed multijurisdictional (Quebec and Ontario) concurrent triangulation mixed-methods study. In both provinces, a qualitative descriptive study will be used to explore innovations in patient-centred multimorbidity care...
May 9, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28483545/developing-your-360-degree-leadership-potential
#16
Nupur Verma, Tan-Lucien Mohammed, Puneet Bhargava
Radiologists serve in leadership roles throughout their career, making leadership education an integral part of their development. A maxim of leadership style is summarized by 360-Degree Leadership, which highlights the ability of a leader to lead from any position within the organization while relying on core characteristics to build confidence from within their team. The qualities of leadership discussed can be learned and applied by radiologists at any level. These traits can form a foundation for the leader when faced with unfavorable events, which themselves allow the leader an opportunity to build trust...
May 5, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28480493/effects-of-sectoral-diversity-on-community-coalition-processes-and-outcomes
#17
Louis D Brown, Rebecca Wells, Eric C Jones, Sarah Meyer Chilenski
Collaboration with diverse partners is challenging but essential for the implementation of prevention programs and policies. Increased communication with partners from diverse sectors may help community coalitions overcome the challenges that diversity presents. We examined these issues empirically in a study of 17 substance use prevention coalitions in Mexico. Building on coalition and workgroup literatures, we hypothesized that sectoral diversity would improve outcomes but undermine coalition processes. Conversely, we expected uniformly positive effects from higher levels of intersectoral communication...
May 8, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28477261/barriers-to-collaborative-anesthetic-care-between-anesthesiologists-and-nurses-on-the-labour-and-delivery-unit-a-study-using-a-modified-delphi-technique
#18
Lillia Y Fung, Kristi Downey, Nancy Watts, Jose C A Carvalho
INTRODUCTION: The practice of obstetrical anesthesia relies on collaborative effort between anesthesiologists and nurses, but teamwork remains a challenge. We sought to identify a consensus on the perceived barriers to collaborative care between anesthesiologists and perinatal nurses in a Canadian tertiary labour and delivery (L&D) unit. METHODS: A cross-sectional consensus-building study was conducted using a modified Delphi technique. We aimed to reach consensus on the barriers to collaborative care as well as to identify the reasons behind the issues and possible interventions...
May 5, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28470640/vermeidung-von-feuer-brand-explosion-im-op
#19
Hartmut Gehring, Klaas Rackebrandt
The combination of an oxidant source, ignition energy and flammable material is the reason for fire, burning and explosion (FBE) in the OR. Attending anaesthesiologists face these risks in their daily routine. Mostly, a situation with FBE arises in an unexpected situation. It is essential to have at hand a catalogue of measures to prevent severe injuries to patients and avoid material damages. There is a systematic way to decrease the risk: awareness and definition of high-risk situations; team work; building up a strategy to avoid the occurrence of fire, burning and explosion in high-risk situations...
April 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28470076/examining-the-influence-of-family-physician-supply-on-district-health-system-performance-in-south-africa-an-ecological-analysis-of-key-health-indicators
#20
Klaus B Von Pressentin, Bob J Mash, Tonya M Esterhuizen
BACKGROUND: The supply of appropriate health workers is a key building block in the World Health Organization's model of effective health systems. Primary care teams are stronger if they contain doctors with postgraduate training in family medicine. The contribution of such family physicians to the performance of primary care systems has not been evaluated in the African context. Family physicians with postgraduate training entered the South African district health system (DHS) from 2011...
April 28, 2017: African Journal of Primary Health Care & Family Medicine
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