keyword
https://read.qxmd.com/read/38497881/metabolic-control-level-and-glucose-variability-in-adolescents-with-type-1-diabetes-during-low-and-high-intensity-exercise
#1
JOURNAL ARTICLE
M Skalska, A Myśliwiec, A Michalak, J Chrzanowski, A Lejk, J Jastrzębska, Ł Radzimiński, G F Lopez-Sanchez, K Myśliwiec, Z Jastrzębski, K Weiss, B Knechtle
OBJECTIVE: The main purpose of this study was to characterize the determinants of metabolic changes in young type 1 diabetes (T1DM) and to determine glycemic variability during low and high-intensity exercise. PATIENTS AND METHODS: 20 young male T1DM patients were divided into two subgroups characterized by levels of glycated hemoglobin (HbA1c): HbA1c<7.3% (better HbA1c subgroup, n=10) and with levels HbA1c>7.3% (worse HbA1c subgroup, n=10). All participants performed a maximal oxygen uptake test and two efforts of various intensities (45 minutes of aerobic exercise and 30 minutes of mixed aerobic-anaerobic intensity exercise)...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38484984/innovations-using-telemedicine-to-improve-care-of-predominantly-non-white-youth-with-suboptimal-insulin-dependent-diabetes-control
#2
JOURNAL ARTICLE
Lisa Rasbach, Ginna Purrington, Deanna Adkins, Robert Benjamin
AIM: Despite advances in diabetes treatments, youth commonly fail to meet glucose targets. Telehealth support may help youth meet diabetes related goals. The objective of the project was to assess whether intensive telehealth support in a group of poorly controlled youth with diabetes would help improve glycated hemoglobin (HbA1c) levels and decrease hospitalization rates over a 12-month time frame. METHODS: This quality improvement project included youth aged 8-18 with suboptimal insulin dependent diabetes control and Medicaid insurance, who were willing to use continuous glucose monitoring (CGM)...
March 12, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38484336/haptoglobin-phenotype-and-intensive-glycemic-control-for-coronary-artery-disease-risk-reduction-in-people-with-type-2-diabetes-the-advance-study
#3
JOURNAL ARTICLE
Leah E Cahill, Rachel A Warren, Allie S Carew, Andrew P Levy, John Sapp, Michelle Samuel, Elizabeth Selvin, Samantha K Lavallée, Neil Poulter, Michel Marre, Stephen Harrap, Giuseppe Mancia, Katie Harris, John Chalmers, Mark Woodward, Eric B Rimm
OBJECTIVE: Intensive glycemic control reduced coronary artery disease (CAD) events among the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study participants with the haptoglobin (Hp)2-2 phenotype but not in participants without the Hp2-2 phenotype. It is unknown whether and how these results translate across different demographic/clinical characteristics and treatment strategies. RESEARCH DESIGN AND METHODS: Haptoglobin phenotype was measured in available samples from the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) biomarker case-cohort study...
March 14, 2024: Diabetes Care
https://read.qxmd.com/read/38479350/glycemic-control-and-retinal-microvascular-changes-in-type-2-diabetes-mellitus-patients-without-clinical-retinopathy
#4
JOURNAL ARTICLE
Kangmin Lee, Ga Hye Lee, Seung Eun Lee, Jee Myung Yang, Kunho Bae
BACKGROUND: To investigate the association of glycemic control and retinal microvascular changes in patients with type 2 diabetes mellitus (T2DM) without diabetic retinopathy (DR). METHODS: This retrospective, observational, cohort study included patients with T2DM without DR. The patients were categorized into intensive control (IC; mean glycosylated hemoglobin [HbA1c] ≤7.0%) and moderate control (MC; mean HbA1c >7.0%) groups. Optical coherence tomography (OCT) and swept-source OCT angiography (OCTA) image parameters were compared between three groups, including healthy controls...
March 13, 2024: Diabetes & Metabolism Journal
https://read.qxmd.com/read/38477318/high-intensity-interval-versus-moderate-intensity-continuous-exercise-training-on-glycemic-control-beta-cell-function-and-aerobic-fitness-in-women-with-type-2-diabetes
#5
JOURNAL ARTICLE
Arghavan Niyazi, Seyed Mohammad Ali Yasrebi, Mohtaram Yazdanian, Gholam Rasul Mohammad Rahimi
Objective: This study aimed to compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on glycemic control, beta-cell function, and aerobic fitness in women with Type 2 Diabetes Mellitus (T2DM). Methods: Thirty-six women with T2DM were assigned equally to HIIT, MICT, and control (CON) groups. Participants in the exercise cohorts underwent a 12-week training regimen (three sessions per week), while the CON group maintained an inactive lifestyle. Glycaemia variables, beta-cell function, maximal oxygen uptake (VO2max ), lipid profiles, and body composition were assessed at baseline and post-intervention...
March 13, 2024: Biological Research for Nursing
https://read.qxmd.com/read/38476508/cost-effectiveness-of-inpatient-continuous-glucose-monitoring
#6
JOURNAL ARTICLE
David Veríssimo, Beatriz R Pereira, Joana Vinhais, Catarina Ivo, Ana C Martins, João N Silva, Dolores Passos, Luís Lopes, João Jácome de Castro, Mafalda Marcelino
Introduction Our department conducted a retrospective cohort study to compare the efficacy of continuous glucose monitoring devices versus capillary blood glucose in the glycemic control of inpatient type 2 diabetes on intensive insulin therapy in a Portuguese hospital. The use of continuous glucose monitoring devices was associated with improved glycemic control, including an increased number of glucose readings within target range and reduced hyperglycemic events, being safe concerning hypoglycemias...
March 2024: Curēus
https://read.qxmd.com/read/38472157/safety-and-efficacy-of-tight-versus-loose-glycemic-control-in-acute-stroke-patients-a-meta-analysis-of-randomized-controlled-trials
#7
JOURNAL ARTICLE
Shuangzhe Wu, Yuke Mao, Sijia Chen, Peiyan Pan, Huiying Zhang, Siqi Chen, Jue Liu, Donghua Mi
BACKGROUND: Hyperglycemia is associated with worse stroke outcomes but it is uncertain whether tight glycaemic control during the acute stroke period is associated with a better outcome. We conducted a meta-analysis to compare the effect of tight glycemic control versus loose glycemic control in the acute phase of stroke patients. METHODS: A literature search was performed to identify randomized controlled trials (RCTs) comparing the safety and efficacy of tight glycemic control with a relatively loose control of blood glucose of acute stroke (ischemic or hemorrhagic) patients within 24 hours after stroke onset...
March 12, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38467770/association-between-glycemic-variability-and-short-term-mortality-in-patients-with-acute-kidney-injury-a-retrospective-cohort-study-of-the-mimic-iv-database
#8
JOURNAL ARTICLE
Yifan Guo, Yue Qiu, Taiqi Xue, Yi Zhou, Pu Yan, Shiyi Liu, Shiwei Liu, Wenjing Zhao, Ning Zhang
Acute kidney injury (AKI) represents a significant challenge to global public health problem and is associated with poor outcomes. There is still considerable debate about the effect of mean blood glucose (MBG) and coefficient of variation (CV) of blood glucose on the short-term mortality of AKI patients. This retrospective cohort study aimed to explore the association between glycemic variability and short-term mortality in patients with AKI. Data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database were analyzed, including 6,777 adult AKI patients...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38464368/balancing-act-the-dilemma-of-rapid-hyperglycemia-correction-in-diabetes-management
#9
EDITORIAL
Ke-Xin Zhang, Cheng-Xia Kan, Xiao-Dong Sun
The global diabetes surge poses a critical public health challenge, emphasizing the need for effective glycemic control. However, rapid correction of chronic hyperglycemia can unexpectedly trigger microvascular complications, necessitating a reevaluation of the speed and intensity of glycemic correction. Theories suggest swift blood sugar reductions may cause inflammation, oxidative stress, and neurovascular changes, resulting in complications. Healthcare providers should cautiously approach aggressive glycemic control, especially in long-standing, poorly controlled diabetes...
February 15, 2024: World Journal of Diabetes
https://read.qxmd.com/read/38458180/trehalose-improved-20-min-cycling-time-trial-performance-after-100-min-cycling-in-amateur-cyclists
#10
JOURNAL ARTICLE
Nathan Gobbi de Oliveira, Luana Farias de Oliveira, Rafael Pires da Silva, Tamires Nunes Oliveira, Gabriella Berwig Möller, Juliana Murasaki, Manoel Antônio Ramires, Rafael de Almeida Azevedo, Guilherme Giannini Artioli, Hamilton Roschel, Bruno Gualano, Bryan Saunders
Carbohydrate (CHO) supplementation during endurance exercise can improve performance. However, it is unclear whether low glycemic index (GI) CHO leads to differential ergogenic and metabolic effects compared with a standard high GI CHO. This study investigated the ergogenic and metabolic effects of CHO supplementation with distinct GIs, namely, (a) trehalose (30 g/hr), (b) isomaltulose (30 g/hr), (c) maltodextrin (60 g/hr), and (d) placebo (water). In this double-blind, crossover, counterbalanced, placebo-controlled study, 13 male cyclists cycled a total of 100 min at varied exercise intensity (i...
March 7, 2024: International Journal of Sport Nutrition and Exercise Metabolism
https://read.qxmd.com/read/38454631/novel-automated-self-adjusting-subcutaneous-insulin-algorithm-improves-glycemic-control-and-physician-efficiency-in-hospitalized-patients
#11
JOURNAL ARTICLE
Paras B Mehta, Michael A Kohn, Esther Rov-Ikpah, Craig San Luis, Craig Johnson, Gwendolyn Lee, Suneil Koliwad, Robert J Rushakoff
BACKGROUND: Hyperglycemia occurs in 22% to 46% of hospitalized patients, negatively affecting patient outcomes, including mortality, inpatient complications, length of stay, and hospital costs. Achieving inpatient glycemic control is challenging due to inconsistent caloric intake, changes from home medications, a catabolic state in the setting of acute illness, consequences of acute inflammation, intercurrent infection, and limitations in labor-intensive glucose monitoring and insulin administration...
March 7, 2024: Journal of Diabetes Science and Technology
https://read.qxmd.com/read/38440785/exercise-training-modalities-in-prediabetes-a-systematic-review-and-network-meta-analysis
#12
JOURNAL ARTICLE
Hang Zhang, Yuting Guo, Guangshun Hua, Chenyang Guo, Simiao Gong, Min Li, Yan Yang
BACKGROUND: Lifestyle modification based on exercise intervention is still the primary way to delay or reverse the development of diabetes in patients with prediabetes. However, there are still challenges in setting up a detailed exercise prescription for people with prediabetes. This study mainly ranks exercise prescriptions by comparing the improvement of glucose and lipid metabolism and the level of weight loss in patients. METHOD: All studies on exercise intervention in prediabetes were identified by searching five electronic databases...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38435452/the-effects-of-resistance-exercise-training-on-skeletal-muscle-metabolism-and-insulin-resistance-development-in-female-rodents-with-type-1-diabetes
#13
JOURNAL ARTICLE
Mitchell J Sammut, David P McBey, Amit P Sayal, C W James Melling
The etiology of insulin resistance (IR) development in type 1 diabetes mellitus (T1DM) remains unclear; however, impaired skeletal muscle metabolism may play a role. While IR development has been established in male T1DM rodents, female rodents have yet to be examined in this context. Resistance exercise training (RT) has been shown to improve IR and is associated with a lower risk of hypoglycemia onset in T1DM compared to aerobic exercise. The purpose of this study was to investigate the effects of RT on IR development in female T1DM rodents...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38432863/optimal-exercise-combinations-for-patients-with-diabetes
#14
JOURNAL ARTICLE
Yanhui Lin, Xia Cao, Jiangang Wang, Yu Liu
OBJECTIVES: Exercise is a key way to control the blood glucose, which can improve blood lipids and blood pressure, reduce glycated hemoglobin levels, and increase insulin sensitivity. It is of great significance for maintaining blood glucose homeostasis. This study aims to explore the optimal exercise combinations suitable for diabetic patients, and to provide scientific and effective personalized exercise guidance for diabetic patients. METHODS: The physical examination data and questionnaire results of were collected from the Third Xiangya Hospital of Central South University...
November 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/38425888/recurrent-depression-relates-to-worse-outcomes-than-single-episode-depression-among-hispanic-adolescents-with-diabetes
#15
JOURNAL ARTICLE
Keiliany Rivera-Santiago, Eduardo Cumba-Aviles, Demivette Gómez-Rivera
BACKGROUND: Adolescents with type 1 diabetes (T1D) are at increased risk for depression. A history of recurrent depression (HRD) may relate to worse health outcomes than single-episode depression. However, no study has explored this issue among T1D adolescents. PARTICIPANTS AND PROCEDURE: We examined differences in psychosocial and diabetes-related outcomes between T1D adolescents with (G1; n = 33) and without (G2; n = 18) HRD. Participants were 51 youths (aged 12-17 years) enrolled in a depression treatment study...
2024: Health Psychology Report
https://read.qxmd.com/read/38423770/intensive-glycaemic-targets-in-overweight-and-obese-individuals-with-gestational-diabetes-mellitus-clinical-trial-protocol-for-the-igdm-study
#16
JOURNAL ARTICLE
Christina M Scifres, Ashley N Battarbee, Maisa N Feghali, Stephanie Pierce, Rodney K Edwards, Emily M Smith, David Guise, Sruthi Bhamidipalli, Joanne Daggy, Methodius G Tuuli
INTRODUCTION: The prevalence of both obesity and gestational diabetes mellitus (GDM) has increased, and each is associated with adverse perinatal outcomes including fetal overgrowth, neonatal morbidity, hypertensive disorders of pregnancy and caesarean delivery. Women with GDM who are also overweight or obese have higher rates of pregnancy complications when compared with normal-weight women with GDM, which may occur in part due to suboptimal glycaemic control. The current recommendations for glycaemic targets in pregnant women with diabetes are based on limited evidence and exceed the mean fasting (70...
February 29, 2024: BMJ Open
https://read.qxmd.com/read/38419951/glycemic-variability-evaluated-by-hba1c-rather-than-fasting-plasma-glucose-is-associated-with-adverse-cardiovascular-events
#17
JOURNAL ARTICLE
Lijuan Sheng, Guifang Yang, Xiangping Chai, Yang Zhou, Xin Sun, Zhenhua Xing
BACKGROUND: Although studies have shown that glycemic variability is positively associated with an increased risk of cardiovascular disease, few studies have compared hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) variability with adverse cardiovascular events in patients with type 2 diabetes mellitus (T2DM). METHODS: This was a post hoc analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study. Cox proportional hazards models were used to explore the relationship between HbA1c or FPG variability and the incidence of major adverse cardiovascular events (MACEs)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38413682/relationship-between-time-weighted-average-glucose-and-mortality-in-critically-ill-patients-a-retrospective-analysis-of-the-mimic-iv-database
#18
JOURNAL ARTICLE
Mengwen Feng, Jing Zhou
Blood glucose management in intensive care units (ICU) remains a controversial topic. We assessed the association between time-weighted average glucose (TWAG) levels and ICU mortality in critically ill patients in a real-world study. This retrospective study included critically ill patients from the Medical Information Mart for Intensive Care IV database. Glycemic distance is the difference between TWAG in the ICU and preadmission usual glycemia assessed with glycated hemoglobin at ICU admission. The TWAG and glycemic distance were divided into 4 groups and 3 groups, and their associations with ICU mortality risk were evaluated using multivariate logistic regression...
February 27, 2024: Scientific Reports
https://read.qxmd.com/read/38402400/intensive-lifestyle-intervention-in-type-2-diabetes-and-risk-of-incident-coronary-artery-disease-for-the-common-haptoglobin-phenotypes-the-look-ahead-study
#19
JOURNAL ARTICLE
Rachel A Warren, Michael P Bancks, Allie S Carew, Andrew P Levy, John Sapp, Judy Bahnson, Cora E Lewis, Eric B Rimm, Mark A Espeland, Leah E Cahill
BACKGROUND: Intensive glycemic control reduced coronary artery disease (CAD) events among the Action to Control Cardiovascular Disease Risk in Diabetes (ACCORD) participants with the haptoglobin (Hp) 2-2 phenotype only. It remains unknown whether Hp phenotype modifies the effect of an intensive lifestyle intervention (ILI) on CAD in type 2 diabetes. METHODS: Haptoglobin phenotype was measured in 4542 samples from the Action for Health in Diabetes (Look AHEAD) study...
February 24, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38398029/the-impacts-of-intervertebral-disc-degeneration-of-the-spine-alcohol-consumption-smoking-tobacco-products-and-glycemic-disorders-on-the-expression-profiles-of-neurotrophins-3-and-4
#20
JOURNAL ARTICLE
Rafał Staszkiewicz, Dorian Gładysz, Dawid Sobański, Filip Bolechała, Edward Golec, Werner Dammermann, Beniamin Oskar Grabarek
In the etiology of discogenic pain, attention is paid to the role of neurotrophic factors, which include classic neurotrophins (NTs). This study aimed to assess changes in the concentrations of NT-3 and NT-4 in the intervertebral discs (IVDs) of the lumbosacral (L/S) spine depending on the advancement of degenerative changes, pain severity, habits, and comorbidities. The study group included 113 patients who underwent microdiscectomy due to degenerative IVD disease of the L/S spine. The severity of degenerative IVD changes was assessed using the five-point Pfirrmann scale, and the pain intensity was assessed according to the visual analog scale (VAS)...
February 13, 2024: Biomedicines
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