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https://www.readbyqxmd.com/read/29933311/longitudinal-analysis-of-the-relationships-between-social-support-and-health-related-quality-of-life-in-hematopoietic-stem-cell-transplant-recipients
#1
Yongchun Liang, Haifang Wang, Meie Niu, Xiaming Zhu, Jianzheng Cai, Xiubei Wang
BACKGROUND: The correlation between social support and health-related quality of life (HRQOL) has been well documented, but whether social support changes or whether social support consistently plays a significant role in the various phases of the treatment process remains unknown among hematopoietic stem cell transplantation (HSCT) patients. OBJECTIVES: The aims of this study were to assess the changing trends of HRQOL and social support and evaluate the relationship between HRQOL and social support before and after transplantation...
June 22, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29933104/assessment-of-cytotoxicity-and-mutagenicity-of-exfoliated-graphene
#2
Katsuhide Fujita, Seiji Take, Ryotaro Tani, Junko Maru, Sawae Obara, Shigehisa Endoh
Graphene and related materials (GRMs) have unique optical and thermal characteristics and are expected to be adopted for industrial applications. However, there are concerns with respect to their safety to human health. To conduct cytotoxicity and mutagenicity assessments, exfoliated graphene (EGr) dispersed in Tween-20® was diluted in cell culture medium. Rat alveolar macrophage viability significantly decreased after 24 h exposure to 1 and 10 μg/mL EGr. No significant levels of intracellular reactive oxygen species were detected in the 2',7'-dichlorodihydrofluorescin diacetate assay after 24 h of exposure to EGr...
June 19, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29932862/subchondral-bone-and-the-osteochondral-unit-basic-science-and-clinical-implications-in-sports-medicine
#3
Bryan M Saltzman, Jonathan C Riboh
CONTEXT: Articular cartilage injuries and early osteoarthritis are among the most common conditions seen by sports medicine physicians. Nonetheless, treatment options for articular degeneration are limited once the osteoarthritic cascade has started. Intense research is focused on the use of biologics, cartilage regeneration, and transplantation to help maintain and improve cartilage health. An underappreciated component of joint health is the subchondral bone. EVIDENCE ACQUISITION: A comprehensive, nonsystematic review of the published literature was completed via a PubMed/MEDLINE search of the keywords "subchondral" AND "bone" from database inception through December 1, 2016...
June 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29932209/hypoxia-negatively-affects-senescence-in-osteoclasts-and-delays-osteoclastogenesis
#4
Ben Gorissen, Alain de Bruin, Alberto Miranda-Bedate, Nicoline Korthagen, Claudia Wolschrijn, Teun J de Vries, René van Weeren, Marianna A Tryfonidou
Cellular senescence, that is, the withdrawal from the cell cycle, combined with the acquirement of the senescence associated secretory phenotype has important roles during health and disease and is essential for tissue remodeling during embryonic development. Osteoclasts are multinucleated cells, responsible for bone resorption, and cell cycle arrest during osteoclastogenesis is well recognized. Therefore, the aim of this study was to investigate whether these cells should be considered senescent and to assess the influence of hypoxia on their potential senescence status...
June 22, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29931664/calcium-and-vitamin-d-in-bone-fracture-healing-and-post-traumatic-bone-turnover
#5
V Fischer, M Haffner-Luntzer, M Amling, A Ignatius
Calcium and vitamin D are essential for maintaining bone health. Therefore, deficiencies in calcium and vitamin D are major risk factors for osteoporosis development. Because sufficient amounts of calcium are also required for fracture-callus mineralisation, compromised bone repair that is frequently observed in osteoporotic patients might be attributed to calcium and vitamin D deficiencies. Consequently, calcium and vitamin D supplementation represents a potential strategy for treating compromised fracture healing in osteoporotic patients...
June 22, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29931419/genetic-variants-of-major-genes-contributing-to-phosphate-and-calcium-homeostasis-and-their-association-with-serum-parameters-in-pigs
#6
Franziska Just, Henry Reyer, Eduard Muráni, Siriluck Ponsuksili, Michael Oster, Klaus Wimmers
Calcium and phosphorus are irreplaceable components of life. Tracking the fate of calcium and phosphorus in organisms deserves high attention due to their relevance in bone metabolism and subsequently animal health. Indeed, bone serves as reservoir for calcium and phosphorus, whose formation and resorption follow specific molecular routes including hormones, receptors, and transcription factors. The objective of the study was to analyze the genetic variation of major components driving mineral utilization such as calcitonin receptor, calcium sensing receptor, fibroblast growth factor 23 (FGF23), parathyroid hormone receptor, osteopontin, stanniocalcin 1, RAF-type zinc finger domain containing 1 (TRAFD1), and vitamin D receptor...
June 22, 2018: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29931084/palliative-pain-relief-and-safety-of-percutaneous-radiofrequency-ablation-combined-with-cement-injection-for-bone-metastasis
#7
Wei Zhao, Hui Wang, Ji-Hong Hu, Zhao-Hong Peng, Jin-Zhou Chen, Jian-Qiang Huang, Yong-Neng Jiang, Gang Luo, Gen-Fa Yi, Jin Shen, Bu-Lang Gao
Purpose: To investigate the pain relief effect and safety of percutaneous radiofrequency ablation (RFA) with a multitined electrode combined with cement injection in patients with painful metastatic bone tumors. Materials and methods: Sixteen patients with 34 osteolytic metastatic lesions were treated with RFA including 4 males and 12 females (age range 54-84). Thirteen patients with spinal metastases received additional cement injection. Medical imaging, a visual analog scale (VAS) and the EORTC QLQ-C30 were performed to evaluate the metastatic lesion, pain and quality of life, respectively, before and after RFA and at follow-ups...
June 20, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29930782/management-of-a-crown-root-fracture-a-novel-technique-with-interdisciplinary-approach
#8
Amaia Artieda-Estanga, Pablo Castelo-Baz, Alba Bello-Castro, Isabel Ramos-Barbosa, Benjamin Martin-Biedma, Juan Blanco-Carrion
Anterior teeth with subgingival fractures require a complex treatment plan that addresses biologic, functional and aesthetic factors. This case report describes the management of a crown-root fractured maxillary left central incisor. An interdisciplinary approach was used to restore the tooth due to the complex nature of the treatment. Orthodontic extrusion was performed to move the fracture line above the alveolar bone and periodontal surgery to recontour the altered gingival margin. Finally, the incisor was restored performing a root canal retreatment with a fiber post and a full ceramic crown...
June 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29930358/is-osteoporosis-a-risk-factor-for-implant-survival-or-failure
#9
Alessandro Grisa, Analia Veitz-Keenan
Data sourcesAn electronic search was performed in PubMed, Web of Science and the Cochrane Library and SciELO databases up to September 2016. References of included studies were also searched. English language restriction was applied.Study selectionClinical monitoring studies with at least six months of follow-up, including retrospective studies, prospective studies, and controlled and randomised clinical trials. Clinical case studies were excluded from the sample and only studies with a minimum of five patients were considered...
June 2018: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29930214/-a-case-of-primary-extradural-meningioma-located-at-the-high-convexity-a-case-report-and-review-of-the-literature
#10
Yohtaro Sakakibara, Yoshio Taguchi, Homare Nakamura, Hidetaka Onodera, Daisuke Wakui, Tetsuya Ikeda, Yoshio Aida
OBJECTIVES: Primary meningiomas arising outside the intracranial component are rather rare and have been termed primary extradural meningiomas(PEMs). We present a case of an intraosseous-type PEM occurring at a high convexity location and discuss the clinical characteristics of PEMs. CASE: An 80-year-old woman presented with a soft and painless subcutaneous mass of approximately 10 cm in diameter in the right parietal region, which had appeared 1 year previously...
June 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29928541/the-art-of-building-bone-emerging-role-of-chondrocyte-to-osteoblast-transdifferentiation-in-endochondral-ossification
#11
Patrick Aghajanian, Subburaman Mohan
There is a worldwide epidemic of skeletal diseases causing not only a public health issue but also accounting for a sizable portion of healthcare expenditures. The vertebrate skeleton is known to be formed by mesenchymal cells condensing into tissue elements (patterning phase) followed by their differentiation into cartilage (chondrocytes) or bone (osteoblasts) cells within the condensations. During the growth and remodeling phase, bone is formed directly via intramembranous ossification or through a cartilage to bone conversion via endochondral ossification routes...
2018: Bone Research
https://www.readbyqxmd.com/read/29927860/cost-effectiveness-of-a-bone-anchored-annular-closure-device-versus-conventional-lumbar-discectomy-in-treating-lumbar-disc-herniations
#12
Jared Ament, Zhuo Yang, Bart Thaci, Edwin Kulubya, Wellington Hsu, Gerrit Bouma, Kee D Kim
STUDY DESIGN: Cost-utility analysis of an annular closure device (ACD) based on data from a prospective, multicenter randomized controlled trial (RCT) OBJECTIVE.: Determine the cost-effectiveness of a novel ACD in a patient population at high risk for recurrent herniation following discectomy SUMMARY OF BACKGROUND DATA.: Lumbar disc herniation patients with annular defect widths ≥ 6 mm are at high risk for recurrent herniation following limited discectomy. Recurrent herniation is associated with worse clinical outcomes and greater healthcare costs...
June 20, 2018: Spine
https://www.readbyqxmd.com/read/29927530/nutrition-implications-for-long-term-survivors-of-pancreatic-cancer-surgery
#13
REVIEW
Maria Q B Petzel, Leah Hoffman
With slowly increasing survival rates in pancreatic cancer and international consensus guidelines recommending surgical resection of premalignant lesions, survival post-pancreatic resection is increasing. With longer survival time, the significant comorbidities of such major surgery have far-reaching effects on the nutrition status of the survivor of pancreatic cancer. This review describes the many nutrition-related side effects of pancreatic surgery, including the development of pancreatic enzyme insufficiency, micronutrient deficiencies, diabetes, fatty liver, and metabolic bone disease...
October 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29926955/peri-implant-diseases-and-conditions-consensus-report-of-workgroup-4-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#14
Tord Berglundh, Gary Armitage, Mauricio G Araujo, Gustavo Avila-Ortiz, Juan Blanco, Paulo M Camargo, Stephen Chen, David Cochran, Jan Derks, Elena Figuero, Christoph H F Hämmerle, Lisa J A Heitz-Mayfield, Guy Huynh-Ba, Vincent Iacono, Ki-Tae Koo, France Lambert, Laurie McCauley, Marc Quirynen, Stefan Renvert, Giovanni E Salvi, Frank Schwarz, Dennis Tarnow, Cristiano Tomasi, Hom-Lay Wang, Nicola Zitzmann
A classification for peri-implant diseases and conditions was presented. Focused questions on the characteristics of peri-implant health, peri-implant mucositis, peri-implantitis, and soft- and hard-tissue deficiencies were addressed. Peri-implant health is characterized by the absence of erythema, bleeding on probing, swelling, and suppuration. It is not possible to define a range of probing depths compatible with health; Peri-implant health can exist around implants with reduced bone support. The main clinical characteristic of peri-implant mucositis is bleeding on gentle probing...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926954/peri-implant-mucositis
#15
Lisa J A Heitz-Mayfield, Giovanni E Salvi
OBJECTIVES: This narrative review was prepared for the 2017 World Workshop of the American Academy of Periodontology and European Federation of Periodontology to address key questions related to the clinical condition of peri-implant mucositis, including: 1) the definition of peri-implant mucositis, 2) conversion of peri-implant health to the biofilm-induced peri-implant mucositis lesion, 3) reversibility of peri-implant mucositis, 4) the long-standing peri-implant mucositis lesion, 5) similarities and differences between peri-implant mucositis at implants and gingivitis at teeth, and 6) risk indicators/factors for peri-implant mucositis...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926953/peri-implant-health-peri-implant-mucositis-and-peri-implantitis-case-definitions-and-diagnostic-considerations
#16
Stefan Renvert, G Rutger Persson, Flavia Q Pirih, Paulo M Camargo
The objective of this review is to identify case definitions and clinical criteria of peri-implant healthy tissues, peri-implant mucositis, and peri-implantitis. The case definitions were constructed based on a review of the evidence applicable for diagnostic considerations. In summary, the diagnostic definition of peri-implant health is based on the following criteria: 1) absence of peri-implant signs of soft tissue inflammation (redness, swelling, profuse bleeding on probing), and 2) the absence of further additional bone loss following initial healing...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926949/peri-implant-health
#17
Mauricio G Araujo, Jan Lindhe
OBJECTIVE: The aim is to define clinical and histologic characteristics of peri-implant tissues in health and describe the mucosa-implant interface. IMPORTANCE: An understanding of the characteristics of healthy peri-implant tissues facilitates the recognition of disease (i.e., departure from health). FINDINGS: The healthy peri-implant mucosa is, at the microscopic level, comprised of a core of connective tissue covered by either a keratinized (masticatory mucosa) or non-keratinized epithelium (lining mucosa)...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926944/periodontal-health-and-gingival-diseases-and-conditions-on-an-intact-and-a-reduced-periodontium-consensus-report-of-workgroup-1-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#18
Iain L C Chapple, Brian L Mealey, Thomas E Van Dyke, P Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L Geisinger, Robert J Genco, Michael Glogauer, Moshe Goldstein, Terrence J Griffin, Palle Holmstrup, Georgia K Johnson, Yvonne Kapila, Niklaus P Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A Romito, Lior Shapira, Dimitris N Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926896/somatic-late-effects-in-5-year-survivors-of-neuroblastoma-a-population-based-cohort-study-within-the-adult-life-after-childhood-cancer-in-scandinavia-aliccs-study
#19
Filippa Nyboe Norsker, Catherine Rechnitzer, Luise Cederkvist, Laufey Tryggvadottir, Laura-Maria Madanat-Harjuoja, Ingrid Øra, Halldora K Thorarinsdottir, Kim Vettenranta, Andrea Bautz, Henrik Schrøder, Henrik Hasle, Jeanette Falck Winther
Because of the rarity of neuroblastoma and poor survival until the 1990s, information on late effects in neuroblastoma survivors is sparse. We comprehensively reviewed the long-term risk for somatic disease in neuroblastoma survivors. We identified 721 5-year survivors of neuroblastoma in Nordic population-based cancer registries and identified late effects in national hospital registries covering the period 1977-2012. Detailed treatment information was available for 46% of the survivors. The disease-specific rates of hospitalization of survivors and of 152,231 randomly selected population comparisons were used to calculate standardized hospitalization rate ratios (SHRRs) and absolute excess risks (AERs)...
June 21, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29926499/periodontal-health-and-gingival-diseases-and-conditions-on-an-intact-and-a-reduced-periodontium-consensus-report-of-workgroup-1-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#20
Iain L C Chapple, Brian L Mealey, Thomas E Van Dyke, P Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L Geisinger, Robert J Genco, Michael Glogauer, Moshe Goldstein, Terrence J Griffin, Palle Holmstrup, Georgia K Johnson, Yvonne Kapila, Niklaus P Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A Romito, Lior Shapira, Dimitris N Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable...
June 2018: Journal of Clinical Periodontology
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