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Respiratory physiology

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https://www.readbyqxmd.com/read/28815143/analyzing-electronic-medical-records-to-predict-risk-of-dit-death-intubation-or-transfer-to-icu-in-pediatric-respiratory-failure-or-related-conditions
#1
Teeradache Viangteeravat, Oguz Akbilgic, Robert Lowell Davis
Large volumes of data are generated in hospital settings, including clinical and physiological data generated during the course of patient care. Our goal, as proof of concept, was to identify early clinical factors or traits useful for predicting the outcome, of death, intubation, or transfer to ICU, for children with pediatric respiratory failure. We implemented both supervised and unsupervised methods to extend our understanding on statistical relationships in clinical and physiological data. As a supervised learning method, we use binary logistic regression to predict the risk of developing DIT outcome...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28815072/hybrid-and-total-minimally-invasive-esophagectomy-how-i-do-it
#2
REVIEW
Luigi Bonavina, Emanuele Asti, Andrea Sironi, Daniele Bernardi, Alberto Aiolfi
Esophagectomy is a major surgical procedure associated with a significant risk of morbidity and mortality. Minimally invasive esophagectomy is becoming the preferred approach because of the potential to limit surgical trauma, reduce respiratory complications, and promote earlier functional recovery. Various hybrid and total minimally invasive surgical techniques have been introduced in clinical practice over the past 20 years, and minimally invasive esophagectomy has been shown equivalent to open surgery concerning the short-term outcomes...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28814807/psychological-impact-of-vehicle-exhaust-exposure-insights-from-an-animal-model
#3
Ankita Salvi, Gaurav Patki, Hesong Liu, Samina Salim
Air pollution resulting from exhaust emissions of vehicles has risen in the recent years, reportedly causing major adverse effects on the heart, lungs and the brain. Though respiratory and cardiovascular effects of these emissions are well identified, psychological and neurobiological complications of prolonged exposure to vehicle emissions remain unknown. Pro-oxidants are considered as major constituents of vehicle emissions. This is important considering causal link between oxidative stress and behavioral and cognitive impairments...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814498/both-ways-at-once-keeping-small-airways-clean
#4
REVIEW
Paul M Quinton
The small airways of the lungs are under constant assault from the pathogens and debris in the air that they must conduct to alveoli. Although hygiene is of paramount importance for respiratory health, the underlying principles of airway clearance have not been well integrated or established. Newly emerging concepts of simultaneous absorption and secretion of airway surface liquid (ASL) and the role of [Formula: see text] in the maturation of mucins have advanced from experimental evidence as well as observations from the congenital disease cystic fibrosis (CF) to present a novel model that integrates microanatomy with organ physiology to meet the constant challenge of cleaning small airways...
September 2017: Physiology
https://www.readbyqxmd.com/read/28812308/transcriptional-regulation-of-the-protein-kinase-a-subunits-in-saccharomyces-cerevisiae-during-fermentative-growth
#5
Fiorella Galello, Constanza Pautasso, Sol Reca, Luciana Cañonero, Paula Portela, Silvia Moreno, Silvia Rossi
Yeast cells can adapt their growth in response to the nutritional environment. Glucose is the favorite carbon source of Saccharomyces cerevisiae that prefers a fermentative metabolism despite the presence of oxygen. When glucose is consumed, the cell switches to the aerobic metabolism of ethanol, during the so-called diauxic shift. The difference between fermentative and aerobic growth is in part mediated by a regulatory mechanism called glucose repression. During glucose derepression a profound gene transcriptional reprogramming occurs and genes involved in the utilization of alternative carbon sources are expressed...
August 15, 2017: Yeast
https://www.readbyqxmd.com/read/28811742/respiratory-t-wave-inversion-in-a-patient-with-chest-pain
#6
Himani Sharma, Abhinav Tiwari
T-wave inversion on electrocardiogram (ECG) is always a concerning finding as it is often associated with myocardial ischemia or ventricular strain. Respiratory variation in the T-wave morphology has been reported in the literature; however, the frequency of this observation remains unknown as this is not routinely evaluated. Although the exact physiological mechanisms underlying this ECG change are unclear, it is proposed to be due to the respiratory variation of the heart position resulting in an alteration in T-wave polarity...
2017: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/28809677/application-of-the-4d-xcat-phantoms-in-biomedical-imaging-and-beyond
#7
W Paul Segars, B M W Tsui, Jing Cai, Fang-Fang Yin, George S K Fung, Ehsan Samei
The four dimensional (4D) eXtended CArdiac-Torso (XCAT) series of phantoms was developed to provide accurate computerized models of the human anatomy and physiology. The XCAT series encompasses a vast population of phantoms of varying ages from newborn to adult, each including parameterized models for the cardiac and respiratory motions. With great flexibility in the XCAT's design, any number of body sizes, different anatomies, cardiac or respiratory motions or patterns, patient positions and orientations, and spatial resolutions can be simulated...
August 10, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28809142/massilia-agri-sp-nov-isolated-from-reclaimed-grassland-soil
#8
Dhiraj Kumar Chaudhary, Jaisoo Kim
A light yellow-coloured, Gram-stain-negative, motile and rod-shaped bacterium, designated strain K-3-1T, was isolated from reclaimed grassland soils of Belbari, Morang, Nepal. It was able to grow at 4-45 °C, at pH 5.0-10.0, and at 0-2 % (w/v) NaCl concentrations. This strain was taxonomically characterized by a polyphasic approach. Based on the 16S rRNA gene sequence analysis, strain K-3-1T belongs to the genus Massilia and is closely related to Massilia consociata CCUG 58010T (98.3 % sequence similarity), Massilia tieshanensis TS3T (98...
August 15, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28808334/cardiorespiratory-optimization-during-improvised-singing-and-toning
#9
N F Bernardi, S Snow, I Peretz, H D Orozco Perez, N Sabet-Kassouf, A Lehmann
We evaluated the effect of different forms of singing on cardiorespiratory physiology, and we aimed at disentangling the role of breathing from that of vocal production. Cardiorespiratory recordings were obtained from 20 healthy adults at rest and during: a) singing of familiar slow songs as in the standard form of Western culture; b) improvised vocalization of free vowel sounds, known as toning. To disentangle the role of breathing from that of vocal production, we compared the vocal conditions with matched breathing-only conditions...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806954/-usability-of-data-integration-and-visualization-software-for-multidisciplinary-pediatric-intensive-care-a-human-factors-approach-to-assessing-technology
#10
Ying Ling Lin, Anne-Marie Guerguerian, Jessica Tomasi, Peter Laussen, Patricia Trbovich
BACKGROUND: Intensive care clinicians use several sources of data in order to inform decision-making. We set out to evaluate a new interactive data integration platform called T3™ made available for pediatric intensive care. Three primary functions are supported: tracking of physiologic signals, displaying trajectory, and triggering decisions, by highlighting data or estimating risk of patient instability. We designed a human factors study to identify interface usability issues, to measure ease of use, and to describe interface features that may enable or hinder clinical tasks...
August 14, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28806480/aerosolized-prostacyclins-for-acute-respiratory-distress-syndrome-ards
#11
REVIEW
Arash Afshari, Anders Bastholm Bille, Mikkel Allingstrup
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a critical condition that is associated with high mortality and morbidity. Aerosolized prostacyclin has been used to improve oxygenation despite the limited evidence available so far.This review was originally published in 2010 and updated in 2017. OBJECTIVES: To assess the benefits and harms of aerosolized prostacyclin in adults and children with ARDS. SEARCH METHODS: In this update, we searched CENTRAL (2017, Issue 4); MEDLINE (OvidSP), Embase (OvidSP), ISI BIOSIS Previews, ISI Web of Science, LILACS, CINAHL (EBSCOhost), and three trials registers...
July 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28806218/hypoxemic-patients-with-bilateral-infiltrates-treated-with-high-flow-nasal-cannula-present-a-similar-pattern-of-biomarkers-of-inflammation-and-injury-to-acute-respiratory-distress-syndrome-patients
#12
Marina García-de-Acilu, Judith Marin-Corral, Antonia Vázquez, Laura Ruano, Mònica Magret, Ricard Ferrer, Joan R Masclans, Oriol Roca
OBJECTIVE: To examine whether patients with acute hypoxemia and bilateral opacities treated with high-flow nasal cannula and acute respiratory distress syndrome patients who were directly mechanically ventilated are similar in terms of lung epithelial, endothelial, and inflammatory biomarkers. DESIGN: Prospective, multicenter study. SETTING: ICUs at three university tertiary hospitals. PATIENTS: Intubated and nonintubated patients admitted to the ICU with acute hypoxemia (PaO2/FIO2 ≤ 300) and bilateral opacities...
August 10, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28803134/age-related-changes-of-physiological-performance-and-survivorship-of-bank-voles-selected-for-high-aerobic-capacity
#13
Agata Marta Rudolf, Maciej Jan Dańko, Edyta Teresa Sadowska, Geoffrey Dheyongera, Paweł Koteja
Variation in lifespans is an intriguing phenomenon, but how metabolic rate influence this variation remains unclear. High aerobic capacity can result in health benefits, but also in increased oxidative damage and accelerated ageing. We tested these contradictory predictions using bank voles (Myodes=Clethrionomys glareolus) from lines selected for high swim-induced aerobic metabolism (A), which had about 50% higher maximum metabolic rate and a higher basal and routine metabolic rates, than those from unselected control lines (C)...
August 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28802543/outcomes-and-predictors-of-failure-of-non-invasive-ventilation-in-patients-with-community-acquired-pneumonia-in-the-emergency-department
#14
Amjad Al-Rajhi, Anwar Murad, P Z Li, Jason Shahin
OBJECTIVE: We set out to describe the use and analyze the predictors of non-invasive ventilation failure in patients with community-acquired pneumonia who receive non-invasive ventilation as first line ventilatory therapy in the emergency department. METHODS: A retrospective cohort study was conducted among consecutive patients with community acquired pneumonia requiring ventilator support presenting to two tertiary care university-affiliated emergency departments...
August 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28800963/young-adults-internet-addiction-prediction-by-the-interaction-of-parental-marital-conflict-and-respiratory-sinus-arrhythmia
#15
Hui Zhang, Tracy L Spinrad, Nancy Eisenberg, Yun Luo, Zhenhong Wang
The aim of the current study was to address the potential moderating roles of respiratory sinus arrhythmia (RSA; baseline and suppression) and participant sex in the relation between parents' marital conflict and young adults' internet addiction. Participants included 105 (65 men) Chinese young adults who reported on their internet addiction and their parents' marital conflict. Marital conflict interacted with RSA suppression to predict internet addiction. Specifically, high RSA suppression was associated with low internet addiction, regardless of parental marital conflict; however, for participants with low RSA suppression, a positive relation between marital conflict and internet addiction was found...
August 9, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28799625/the-use-of-a-virtual-patient-to-follow-pleural-pressure-changes-associated-with-therapeutic-thoracentesis
#16
Tomasz Gólczewski, Anna M Stecka, Marcin Michnikowski, Elżbieta M Grabczak, Piotr Korczyński, Rafał Krenke
PURPOSE: Influence of therapeutic thoracentesis on the pleural pressure (Pp) has been discussed in many clinical studies, however reasons of Pp changes are not precisely established. The aim of the study was to use a previously elaborated virtual cardiopulmonary patient (VP) in analysis of impact of physiological factors on Pp during the procedure. METHODS: Simulations were performed on VP with default values of parameters for which VP simulated the respiratory system of the average 50-year-old healthy Polish woman according to spirometric examination...
August 7, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28798335/cd71-erythroid-suppressor-cells-impair-adaptive-immunity-against-bordetella-pertussis
#17
Afshin Namdar, Petya Koleva, Shima Shahbaz, Stacy Strom, Volker Gerdts, Shokrollah Elahi
Infant's immune system cannot control infection or respond to vaccination as efficiently as older individuals, a phenomenon that has been attributed to immunological immaturity. Recently, we challenged this notion and proposed the presence of actively immunosuppressive and physiologically enriched CD71(+) erythroid cells in neonates. Here we utilized Bordetella pertussis, a common neonatal respiratory tract pathogen, as a proof of concept to investigate the role of these cells in adaptive immunity. We observed that CD71(+) cells have distinctive immunosuppressive properties and prevent recruitment of immune cells to the mucosal site of infection...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796188/a-compressed-sensing-based-method-for-reducing-the-sampling-time-of-a-high-resolution-pressure-sensor-array-system
#18
Chenglu Sun, Wei Li, Wei Chen
For extracting the pressure distribution image and respiratory waveform unobtrusively and comfortably, we proposed a smart mat which utilized a flexible pressure sensor array, printed electrodes and novel soft seven-layer structure to monitor those physiological information. However, in order to obtain high-resolution pressure distribution and more accurate respiratory waveform, it needs more time to acquire the pressure signal of all the pressure sensors embedded in the smart mat. In order to reduce the sampling time while keeping the same resolution and accuracy, a novel method based on compressed sensing (CS) theory was proposed...
August 10, 2017: Sensors
https://www.readbyqxmd.com/read/28795798/a-two-photon-and-deep-red-emission-ratiometric-fluorescent-probe-with-a-large-emission-shift-and-signal-ratios-for-sulfur-dioxide-ultrafast-response-and-applications-in-living-cells-brain-tissues-and-zebrafishes
#19
Yanyan Ma, Yonghe Tang, Yuping Zhao, Shiying Gao, Weiying Lin
Sulfur dioxide (SO2) is a dangerous environmental pollutant. Excessive intake of it may cause some respiratory diseases and even lung cancer. The development of effective methods for detecting of SO2 is of great importance for environment and physiology. Herein, we have designed and synthesized a novel two-photon (TP) and deep-red emission ratiometric fluo-rescent probe (CP) for detecting of SO2. Notably, the novel probe CP exhibited ultrafast response to SO2 in less than 5 sec-onds, and displayed a great emission shift (195 nm) and a large emission signal ratio variation (enhancement from 0...
August 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28794470/endocrine-disruptors-induce-perturbations-in-endoplasmic-reticulum-and-mitochondria-of-human-pluripotent-stem-cell-derivatives
#20
Uthra Rajamani, Andrew R Gross, Camille Ocampo, Allen M Andres, Roberta A Gottlieb, Dhruv Sareen
Persistent exposure to man-made endocrine disrupting chemicals during fetal endocrine development may lead to disruption of metabolic homeostasis contributing to childhood obesity. Limited cellular platforms exist to test endocrine disrupting chemical-induced developmental abnormalities in human endocrine tissues. Here we use an human-induced pluripotent stem cell-based platform to demonstrate adverse impacts of obesogenic endocrine disrupting chemicals in the developing endocrine system. We delineate the effects upon physiological low-dose exposure to ubiquitous endocrine disrupting chemicals including, perfluoro-octanoic acid, tributyltin, and butylhydroxytoluene, in endocrine-active human-induced pluripotent stem cell-derived foregut epithelial cells and hypothalamic neurons...
August 9, 2017: Nature Communications
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