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Respiratory physiology

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https://www.readbyqxmd.com/read/28233793/development-of-an-ex-vivo-human-porcine-respiratory-model-for-preclinical-studies
#1
Sophie Perinel, Jérémie Pourchez, Lara Leclerc, John Avet, Marc Durand, Nathalie Prévôt, Michèle Cottier, Jean M Vergnon
Anatomical models to study aerosol delivery impose huge limitations and extrapolation to humans remains controversial. This study aimed to develop and validate an ex vivo human-like respiratory tract model easy to use and relevant to compare to in vivo human data. A human plastinated head is connected to an ex vivo porcine pulmonary tract ventilated artificially by passive expansion. A physiological study measures "pleural" depressions, tidal volumes, and minute ventilation for the respiratory rates chosen (10, 15, and 20 per minute) with three inspiratory/expiratory ratios (1/1, 1/2, and 1/3)...
February 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28232807/signaling-pathways-linked-to-serotonin-induced-superoxide-anion-production-a-physiological-role-for-mitochondria-in-pulmonary-arteries
#2
Nafiisha Genet, Marie Billaud, Rodrigue Rossignol, Mathilde Dubois, Jennifer Gillibert-Duplantier, Brant E Isakson, Roger Marthan, Jean-Pierre Savineau, Christelle Guibert
Serotonin (5-HT) is a potent vasoconstrictor agonist and contributes to several vascular diseases including systemic or pulmonary hypertension and atherosclerosis. Although superoxide anion ([Formula: see text]) is commonly associated to cellular damages due to [Formula: see text] overproduction, we previously demonstrated that, in physiological conditions, [Formula: see text] also participates to the 5-HT contraction in intrapulmonary arteries (IPA). Here, we focused on the signaling pathways leading to [Formula: see text] production in response to 5-HT in rat IPA...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28230738/clinical-implications-of-20-hydroxyeicosatetraenoic-acid-in-the-kidney-liver-lung-and-brain-an-emerging-therapeutic-target
#3
REVIEW
Osama H Elshenawy, Sherif M Shoieb, Anwar Mohamed, Ayman O S El-Kadi
Cytochrome P450-mediated metabolism of arachidonic acid (AA) is an important pathway for the formation of eicosanoids. The ω-hydroxylation of AA generates significant levels of 20-hydroxyeicosatetraenoic acid (20-HETE) in various tissues. In the current review, we discussed the role of 20-HETE in the kidney, liver, lung, and brain during physiological and pathophysiological states. Moreover, we discussed the role of 20-HETE in tumor formation, metabolic syndrome and diabetes. In the kidney, 20-HETE is involved in modulation of preglomerular vascular tone and tubular ion transport...
February 20, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28230307/cdkl5-deficiency-entails-sleep-apneas-in-mice
#4
Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Alessandro Silvani, Alice Valli, Rocchina Viggiano, Elisabetta Ciani, Giovanna Zoccoli
A recently discovered neurodevelopmental disorder caused by the mutation of the cyclin-dependent kinase-like 5 gene (CDKL5) entails complex autistic-like behaviours similar to Rett syndrome, but its impact upon physiological functions remains largely unexplored. Sleep-disordered breathing is common and potentially life-threatening in patients with Rett syndrome; however, evidence is limited in children with CDKL5 disorder, and is lacking altogether in adults. The aim of this study was to test whether the breathing pattern during sleep differs between adult Cdkl5 knockout (Cdkl5-KO) and wild-type (WT) mice...
February 23, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28229353/cardiorespiratory-instability-in-monitored-step-down-unit-patients-using-cluster-analysis-to-identify-patterns-of-change
#5
Eliezer L Bose, Gilles Clermont, Lujie Chen, Artur W Dubrawski, Dianxu Ren, Leslie A Hoffman, Michael R Pinsky, Marilyn Hravnak
Cardiorespiratory instability (CRI) in monitored step-down unit (SDU) patients has a variety of etiologies, and likely manifests in patterns of vital signs (VS) changes. We explored use of clustering techniques to identify patterns in the initial CRI epoch (CRI1; first exceedances of VS beyond stability thresholds after SDU admission) of unstable patients, and inter-cluster differences in admission characteristics and outcomes. Continuous noninvasive monitoring of heart rate (HR), respiratory rate (RR), and pulse oximetry (SpO2) were sampled at 1/20 Hz...
February 22, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28227820/evaluating-respiratory-muscle-activity-using-a-wireless-sensor-platform
#6
Luis Estrada, Abel Torres, Leonardo Sarlabous, Raimon Jane, Luis Estrada, Abel Torres, Leonardo Sarlabous, Raimon Jane, Raimon Jane, Luis Estrada, Leonardo Sarlabous, Abel Torres
Wireless sensors are an emerging technology that allows to assist physicians in the monitoring of patients health status. This approach can be used for the non-invasive recording of the electrical respiratory muscle activity of the diaphragm (EMGdi). In this work, we acquired the EMGdi signal of a healthy subject performing an inspiratory load test. To this end, the EMGdi activity was captured from a single channel of electromyography using a wireless platform which was compared with the EMGdi and the inspiratory mouth pressure (Pmouth) recorded with a conventional lab equipment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227455/a-method-for-extracting-respiratory-frequency-during-blood-pressure-measurement-from-oscillometric-cuff-pressure-pulses-and-korotkoff-sounds-recorded-during-the-measurement
#7
Diliang Chen, Fei Chen, Alan Murray, Dingchang Zheng, Diliang Chen, Fei Chen, Alan Murray, Dingchang Zheng, Dingchang Zheng, Alan Murray, Fei Chen, Diliang Chen
Respiratory frequency is an important physiological feature commonly used to assess health. However, the current measurements involve dedicated devices which not only increase the medical cost but also make health monitoring inconvenient. Earlier studies have shown that respiratory frequency could be extracted from electrocardiography (ECG) signal, but little was done to assess the possibility of extracting respiratory frequency from oscillometric cuff pressure pulses (OscP) or Korotkoff sounds (KorS), which are normally used for measuring blood pressure and more easily accessible than the ECG signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227347/an-eemd-pca-approach-to-extract-heart-rate-respiratory-rate-and-respiratory-activity-from-ppg-signal
#8
Mohammod Abdul Motin, Chandan Kumar Karmakar, Marimuthu Palaniswami, Mohammod Abdul Motin, Chandan Kumar Karmakar, Marimuthu Palaniswami, Marimuthu Palaniswami, Mohammod Abdul Motin, Chandan Kumar Karmakar
The pulse oximeter's photoplethysmographic (PPG) signals, measure the local variations of blood volume in tissues, reflecting the peripheral pulse modulated by cardiac activity, respiration and other physiological effects. Therefore, PPG can be used to extract the vital cardiorespiratory signals like heart rate (HR), respiratory rate (RR) and respiratory activity (RA) and this will reduce the number of sensors connected to the patient's body for recording vital signs. In this paper, we propose an algorithm based on ensemble empirical mode decomposition with principal component analysis (EEMD-PCA) as a novel approach to estimate HR, RR and RA simultaneously from PPG signal...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227081/noninvasive-estimation-of-alveolar-pressure
#9
Francesco Vicario, Roberto Buizza, William A Truschel, Nicolas W Chbat, Francesco Vicario, Roberto Buizza, William A Truschel, Nicolas W Chbat, Francesco Vicario, Roberto Buizza, Nicolas W Chbat, William A Truschel
This paper presents an algorithm for noninvasive estimation of alveolar pressure in mechanically ventilated patients who are spontaneously breathing. Continual monitoring of alveolar pressure is desirable to prevent ventilator-induced lung injury and to assess the intrinsic positive end-expiratory pressure (PEEPi), which is a parameter of clinical relevance in respiratory care and difficult to measure noninvasively. The algorithm is based on a physiological model of the respiratory system and, as such, it also provides insight into the respiratory mechanics of the patient under mechanical ventilation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226991/noninvasive-health-condition-monitoring-device-for-workers-at-high-altitudes-conditions
#10
Pablo Aqueveque, Cristopher Gutierrez, Francisco Saavedra, Esteban J Pino, Pablo Aqueveque, Cristopher Gutierrez, Francisco Saavedra, Esteban J Pino, Cristopher Gutierrez, Francisco Saavedra, Pablo Aqueveque, Esteban J Pino
This work presents the design and implementation of a continuous monitoring device to control the health state of workers, for instance miners, at high altitudes. The extreme ambient conditions are harmful for peoples' health; therefore a continuous control of the workers' vital signs is necessary. The developed system includes physiological variables: electrocardiogram (ECG), respiratory activity and body temperature (BT), and ambient variables: ambient temperature (AT) and relative humidity (RH). The noninvasive sensors are incorporated in a t-shirt to deliver a functional device, and maximum comfort to the users...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226761/multisensor-data-fusion-for-enhanced-respiratory-rate-estimation-in-thermal-videos
#11
Carina B Pereira, Xinchi Yu, Vladimir Blazek, Boudewijn Venema, Steffen Leonhardt, Carina B Pereira, Xinchi Yu, Vladimir Blazek, Boudewijn Venema, Steffen Leonhardt, Xinchi Yu, Vladimir Blazek, Carina B Pereira, Boudewijn Venema, Steffen Leonhardt
Scientific studies have demonstrated that an atypical respiratory rate (RR) is frequently one of the earliest and major indicators of physiological distress. However, it is also described in the literature as "the neglected vital parameter", mainly due to shortcomings of clinical available monitoring techniques, which require attachment of sensors to the patient's body. The current paper introduces a novel approach that uses multisensor data fusion for an enhanced RR estimation in thermal videos. It considers not only the temperature variation around nostrils and mouth, but the upward and downward movement of both shoulders...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226588/robust-estimation-of-respiratory-rate-via-ecg-and-ppg-derived-respiratory-quality-indices
#12
Drew A Birrenkott, Marco A F Pimentel, Peter J Watkinson, David A Clifton, Drew A Birrenkott, Marco A F Pimentel, Peter J Watkinson, David A Clifton, Peter J Watkinson, Marco A F Pimentel, Drew A Birrenkott, David A Clifton
Respiratory rate (RR) is one of the most informative indicators of a patient's health status. However, automated, non-invasive measurements of RR are insufficiently robust for use in clinical practice. A number of methods have been described in the literature to estimate RR from both photo-plethysmography (PPG) and electrocardiography (ECG) based on three physiological modulations of respiration: amplitude modulation (AM), frequency modulation (FM), and baseline wander (BW). However, the quality of the respiratory information acquired is highly patient-dependent and often too noisy to be used...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226488/synchrosqueezing-an-effective-method-for-analyzing-doppler-radar-physiological-signals
#13
Ehsan Yavari, Ashikur Rahman, Jia Xu, Danilo P Mandic, Olga Boric-Lubecke, Ehsan Yavari, Ashikur Rahman, Jia Xu, Danilo P Mandic, Olga Boric-Lubecke, Jia Xu, Olga Boric-Lubecke, Ehsan Yavari, Danilo P Mandic, Ashikur Rahman
Doppler radar can monitor vital sign wirelessly. Respiratory and heart rate have time-varying behavior. Capturing the rate variability provides crucial physiological information. However, the common time-frequency methods fail to detect key information. We investigate Synchrosqueezing method to extract oscillatory components of the signal with time varying spectrum. Simulation and experimental result shows the potential of the proposed method for analyzing signals with complex time-frequency behavior like physiological signals...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226365/nasal-anatomy-and-function
#14
Ruchin G Patel
The nose is a complex structure important in facial aesthetics and in respiratory physiology. Nasal defects can pose a challenge to reconstructive surgeons who must re-create nasal symmetry while maintaining nasal function. A basic understanding of the underlying nasal anatomy is thus necessary for successful nasal reconstruction.
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28223945/toward-respiratory-assessment-using-depth-measurements-from-a-time-of-flight-sensor
#15
Charles Sharp, Vahid Soleimani, Sion Hannuna, Massimo Camplani, Dima Damen, Jason Viner, Majid Mirmehdi, James W Dodd
Introduction: There is increasing interest in technologies that may enable remote monitoring of respiratory disease. Traditional methods for assessing respiratory function such as spirometry can be expensive and require specialist training to perform and interpret. Remote, non-contact tracking of chest wall movement has been explored in the past using structured light, accelerometers and impedance pneumography, but these have often been costly and clinical utility remains to be defined. We present data from a 3-Dimensional time-of-flight camera (found in gaming consoles) used to estimate chest volume during routine spirometry maneuvres...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28223465/assessment-of-bohr-and-enghoff-dead-space-equations-in-mechanically-ventilated-children
#16
Pierre Bourgoin, Florent Baudin, David Brossier, Guillaume Emeriaud, Marc Wysocki, Philippe Jouvet
BACKGROUND: Recent findings suggest that using alveolar PCO2 (PACO2 ) estimated by volumetric capnography in the Bohr equation instead of PaCO2 (Enghoff modification) could be appropriate for the calculation of physiological dead space to tidal volume ratio (VD/VT Bohr and VD/VT Enghoff, respectively). We aimed to describe the relationship between these 2 measurements in mechanically ventilated children and their significance in cases of ARDS. METHODS: From June 2013 to December 2013, mechanically ventilated children with various respiratory conditions were included in this study...
February 21, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28223398/exertional-dyspnoea-in-interstitial-lung-diseases-the-clinical-utility-of-cardiopulmonary-exercise-testing
#17
Matteo Bonini, Giuseppe Fiorenzano
Interstitial lung diseases (ILDs) represent a heterogeneous group of pathologies characterised by alveolar and interstitial damage, pulmonary inflammation (usually associated with fibrosis), decreased lung function and impaired gas exchange, which can be attributed to either a known or an unknown aetiology. Dyspnoea is one of the most common and disabling symptoms in patients with ILD, significantly impacting quality of life. The mechanisms causing dyspnoea are complex and not yet fully understood. However, it is recognised that dyspnoea occurs when there is an imbalance between the central respiratory efferent drive and the response of the respiratory musculature...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28221135/impaired-respiration-elicits-srrab-dependent-programmed-cell-lysis-and-biofilm-formation-in-staphylococcus-aureus
#18
Ameya A Mashruwala, Adriana Van De Guchte, Jeffrey M Boyd
Biofilms are communities of microorganisms attached to a surface or each other. Biofilm associated cells are the etiologic agents of recurrent Staphylococcus aureus infections. Infected human tissues are hypoxic or anoxic. S. aureus increases biofilm formation in response to hypoxia, but how this occurs is unknown. In the current study we report that oxygen influences biofilm formation in its capacity as a terminal electron acceptor for cellular respiration. Genetic, physiological, or chemical inhibition of respiratory processes elicited increased biofilm formation...
February 21, 2017: ELife
https://www.readbyqxmd.com/read/28220740/the-spectrum-and-outcome-of-surgical-sepsis-in-pietermaritzburg-south-africa
#19
S Green, V Y Kong, D L Clarke, B Sartorius, J Odendaal, J L Bruce, G L Laing, P Brysiewicz, W Bekker, E Harknett
BACKGROUND: Sepsis is a leading cause of morbidity and mortality worldwide, and the incidence appears to be increasing. In the resource-limited environment in low- and middle-income countries, the management of surgical sepsis (SS) continues to represent a significant portion of the workload for most general surgeons. OBJECTIVE: To describe the spectrum of SS seen at a busy emergency department, and categorise the outcomes. METHODS: The Pietermaritzburg Metropolitan Trauma Service (PMTS) and Pietermaritzburg Metropolitan Surgical Service (PMSS) in KwaZulu-Natal Province, South Africa (SA), maintain a prospective electronic registry...
January 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28217778/a-critical-insight-into-the-development-pipeline-of-microfluidic-immunoassay-devices-for-the-sensitive-quantitation-of-protein-biomarkers-at-the-point-of-care
#20
REVIEW
Ana I Barbosa, Nuno M Reis
The latest clinical procedures for the timely and cost-effective diagnosis of chronic and acute clinical conditions, such as cardiovascular diseases, cancer, chronic respiratory diseases, diabetes or sepsis (i.e. the biggest causes of death worldwide), involve the quantitation of specific protein biomarkers released into the blood stream or other physiological fluids (e.g. urine or saliva). The clinical thresholds are usually in the femtomolar to picolomar range, and consequently the measurement of these protein biomarkers heavily relies on highly sophisticated, bulky and automated equipment in centralised pathology laboratories...
February 20, 2017: Analyst
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