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https://www.readbyqxmd.com/read/28220845/heterogeneous-nuclear-ribonucleoprotein-a1-regulates-rhythmic-synthesis-of-mouse-nfil3-protein-via-ires-mediated-translation
#1
Hyo-Jin Kim, Hwa-Rim Lee, Ji-Young Seo, Hye Guk Ryu, Kyung-Ha Lee, Do-Yeon Kim, Kyong-Tai Kim
Nuclear factor, interleukin 3, regulated (Nfil3, also known as E4 Promoter-Binding Protein 4 (E4BP4)) protein is a transcription factor that binds to DNA and generally represses target gene expression. In the circadian clock system, Nfil3 binds to a D-box element residing in the promoter of clock genes and contributes to their robust oscillation. Here, we show that the 5'-untranslated region (5'-UTR) of Nfil3 mRNA contains an internal ribosome entry site (IRES) and that IRES-mediated translation occurs in a phase-dependent manner...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217779/unusual-binding-selectivity-with-non-selective-homoditopic-pillar-5-arene-oxime-serendipitous-discovery-of-a-unique-approach-to-heterobinuclear-metalation-in-solution
#2
Xiangyang Yuan, Yiming Jia, Yimin Cai, Wen Feng, Yiming Li, Xiaopeng Li, Lihua Yuan
A heterobinuclear complexation strategy on homoditopic pillar[5]arene was developed by using a pillar[5]arene with two rims decorated with benzaldehyde oximes. The unique selective recognition process was found to result from vesicular formation based on a controllable self-assembly, leading to binding of thorium(iv) only onto one rim, with the other rim being unoccupied for subsequent complexation of a second different metal ion.
February 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28217596/distribution-of-abo-and-rh-types-in-voluntary-blood-donors-in-jharkhand-area-as-a-study-conducted-by-rims-ranchi
#3
Anu Singh, Ramesh Kumar Srivastava, Kabita S Deogharia, Kranti Kumar Singh
BACKGROUND: This study was done to know the distribution and frequencies of blood groups among blood donors attending voluntary blood donation camps organized by the Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand so that demand and supply ratio of the four blood groups can be maintained so that no patient dies due to lack of a particular blood group. CONTEXT: Up till now about 400 red cells antigen have been identified. The majority follow Mendelian inheritance...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28214397/a-case-of-iv-degree-on-acute-radiation-dermatitis-in-china
#4
Zhen Shen, Ya-Hong Chen, Yue Chen, Yan Chen, Zhe Lv, Hai-Cheng Gao
This report investigates the nursing procedure of a case of adjuvant therapy of rectal cancer on IV degree of acute radiation dermatitis patients in the penis and scrotum junction. The lesion degree gradually increased. Fixation of the dressing was difficult in the penis and scrotum junction. The concept of wet healing with new dressings was used in patient. The silver ion dressings were used in inhibiting infection, and the wound was covered by the rimmed foam dressings. When it comes to the shaping period, water gel transparent paste was applied instead to cover the wound...
February 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28214200/concurrent-met-copy-number-gain-and-kras-mutation-is-a-poor-prognostic-factor-in-pancreatobiliary-subtype-ampullary-cancers
#5
Mi Jung Kwon, Jeong Won Kim, Jang Yong Jeon, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Kyueng-Whan Min, Ji-Young Choe, Hye Kyung Lee
Hepatocyte growth factor (HGF) and MET are candidates of targeted therapies for cancer patients. Although MET and HGF are commonly expressed in biliary tract cancers, their expression and gene copy number status and their association with KRAS mutations have not been investigated in pancreatobiliary-type ampullary adenocarcinomas (A-ACs), one of the aggressive periampullary cancers. MET and HGF expressions and MET copy number status were examined by performing immunohistochemistry (IHC) and silver in situ hybridization (SISH) in 62 surgically resected, paraffin-embedded tumors, respectively...
January 11, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28212675/sex-differences-in-the-association-of-skin-advanced-glycation-endproducts-with-knee-osteoarthritis-progression
#6
Charles B Eaton, Maria Sayeed, Syeda Ameernaz, Mary B Roberts, John D Maynard, Jeffrey B Driban, Timothy E McAlindon
BACKGROUND: The accumulation of advanced glycation endproducts in articular cartilage has been suggested as an etiologic factor in the development and progression of knee osteoarthritis (KOA). METHODS: We conducted a prospective cohort study of skin advanced glycation endproducts (sAGEs) measured non-invasively by skin intrinsic fluorescence and the relationship between sAGE KOA progression in 160 men and 287 women in a sub-cohort of the Osteoarthritis Initiative at a single site...
February 17, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28207539/role-of-coronary-angiography-for-out-of-hospital-cardiac-arrest-survivors-according-to-postreturn-of-spontaneous-circulation-on-an-electrocardiogram
#7
Tae Rim Lee, Sung Yeon Hwang, Won Chul Cha, Tae Gun Shin, Min Seob Sim, Ik Joon Jo, Keun Jeong Song, Joong Eui Rhee, Yeon Kwon Jeong
Survivors of out-of-hospital cardiac arrest (OHCA) have high mortality and morbidity. An acute coronary event is the most common cause of sudden cardiac death. For this reason, coronary angiography is an important diagnostic and treatment strategy for patients with postcardiac arrest. This study aimed to identify the correlation between postreturn of spontaneous circulation (ROSC) on an electrocardiogram (ECG) and results of coronary angiography of OHCA survivors.We collected data from our OHCA registry from January 2010 to November 2014...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28207530/can-quality-of-recovery-be-enhanced-by-premedication-with-midazolam-a-prospective-randomized-double-blind-study-in-females-undergoing-breast-surgery
#8
Myoung Hwa Kim, Min Soo Kim, Jae Hoon Lee, Jae Hi Seo, Jeong-Rim Lee
BACKGROUND: Preoperative anxiety is known to be related with the postoperative outcomes, although it remains unclear whether pharmacologic anxiolysis preoperatively leads to better postanesthesia recovery. Hence, the purpose of this study was to assess whether midazolam premedication would result in improved Quality of Recovery-40 survey scores, as a postoperative recovery parameter, in female patients undergoing mastectomy. METHODS: This randomized double-blind study was performed at Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28207326/micro-rna-146a-but-not-irak1-is-associated-with-rheumatoid-arthritis-in-the-tunisian-population
#9
Hana Ben Hassine, Asma Boumiza, Rim Sghiri, Khadija Baccouche, Imen Boussaid, Ahlem Atig, Zahid Shakoor, Elyes Bouajina, Ramzi Zemni
BACKGROUND: Rheumatoid arthritis (RA) is characterized by the production of an array of proinflammatory cytokines through the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Interleukin-1 receptor (IL-1R) and Toll-like receptors contain a common cytoplasmic motif the Toll/IL-1R (TIR) homology domain. This motif is required for NF-κB activation. IL-1R-associated kinase 1 (IRAK1) is a key adapter molecule recruited during the signaling cascade of the TIR...
February 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28206771/magnetic-particle-imaging-a-novel-in-vivo-imaging-platform-for-cancer-detection
#10
Elaine Y Yu, Mindy Bishop, Bo Zheng, R Matthew Ferguson, Amit P Khandhar, Scott J Kemp, Kannan M Krishnan, Patrick W Goodwill, Steven M Conolly
Cancer remains one of the leading causes of death worldwide. Biomedical imaging plays a crucial role in all phases of cancer management. Physicians often need to choose the ideal diagnostic imaging modality for each clinical presentation based on complex trade-offs between spatial resolution, sensitivity, contrast, access, cost, and safety. Magnetic particle imaging (MPI) is an emerging tracer imaging modality that detects superparamagnetic iron oxide (SPIO) nanoparticle tracer with high image contrast (zero tissue background signal), high sensitivity (200 nM Fe) with linear quantitation and zero signal depth attenuation...
February 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/28205012/determination-of-urazamide-in-pharmaceutical-preparation-with-room-temperature-ionic-liquid
#11
Narae Seo, Yoo Rim Lee, Hyun Sun Park, Quoc-Ky Truong, Jae-Yong Lee, Hyun Kyu Chung, Yusung Choi, Byeonghee Kim, Sang Beom Han, Kyeong Ho Kim
A high performance liquid chromatographic method was developed and validated for the determination of urazamide in pharmaceutical preparation with novel green aqueous mobile phase modified with room temperature ionic liquids (RTILs). 1-Ethyl-3-methyl-imidazolium tetrafluoroborate ([EMIM][BF4]) was selected as a mobile phase additive to improve retention and avoid baseline disturbances at t0. Various mobile phase parameters such as cation moiety, chaotropic anion moiety, pH and concentration of RTILs were optimized to determine urazamide at the proper retention time...
February 15, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28202394/platelet-rich-plasma-prp-induces-chondroprotection-via-increasing-autophagy-anti-inflammatory-markers-and-decreasing-apoptosis-in-human-osteoarthritic-cartilage
#12
Mayssam Moussa, Daniel Lajeunesse, George Hilal, Oula El Atat, Gaby Haykal, Rim Serhal, Antonio Chalhoub, Charbel Khalil, Nada Alaaeddine
OBJECTIVES: Autophagy constitutes a defense mechanism to overcome aging and apoptosis in osteoarthritic cartilage. Several cytokines and transcription factors are linked to autophagy and play an important role in the degradative cascade in osteoarthritis (OA). Cell therapy such as platelet rich plasma (PRP) has recently emerged as a promising therapeutic tool for many diseases including OA. However, its mechanism of action on improving cartilage repair remains to be determined. The purpose of this study is to investigate the effect of PRP on osteoarthritic chondrocytes and to elucidate the mechanism by which PRP contributes to cartilage regeneration...
February 13, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28198543/deformation-of-the-zurich-cementless-acetabular-cup-caused-by-implantation-in-a-canine-cadaver-model
#13
Geoffrey D Panjeton, Stanley E Kim, Kelvin Chang, Lindsey S Palm, Peter G Ifju
OBJECTIVE: To evaluate the change in geometry of the Zurich total hip arthroplasty (THA) acetabular component after implantation. ANIMALS: Hemipelves from adult mix-breed dogs weighing between 20 and 25 kg. METHODS: Digital image correlation imaging was performed prior to, immediately after, and 24 hours after impaction of Zurich THA acetabular component, and after removal of the cup from the specimen. Patterns of deformation were qualitatively described, and maximal deformations were compared between time points...
February 15, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28197624/-nerve-distribution-and-density-in-the-canine-hip-joint-capsule-comparison-of-healthy-and-dysplastic-hip-joints
#14
Felix Giebels, Andreas Prescher, Stefan Wagenpfeil, Arno Bücker, Sylvia Kinzel
OBJECTIVE: The hip-joint capsule is exposed to increased tension forces during canine hip dysplasia, resulting in inflammation of the capsular tissue. It has been postulated that inflammation is associated with an increased nerve-distribution density. Therefore, it could be supposed that the nerve-distribution density in the hip-joint capsule is higher in dogs with dysplastic hip compared to healthy dogs. MATERIAL AND METHODS: In 16 Labrador Retriever dogs that had been euthanised due to unrelated reasons, the hip joints were classified as normoplastic (group 1, n = 18) or dysplastic (group 2, n = 14) based on radiography...
February 15, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28190621/the-histopathological-differentiation-between-palmar-psoriasis-and-hand-eczema-a-retrospective-review-of-96-cases
#15
Jun Yeong Park, Eun Byul Cho, Eun Joo Park, Hye Rim Park, Kwang Ho Kim, Kwang Joong Kim
BACKGROUND: The histopathologic differences among palmar psoriasis (PP), hand eczema (HE), and hyperkeratotic hand dermatitis (HHD) have been poorly described. OBJECTIVES: We sought to distinguish among PP, HE, and HHD on a histopathologic basis. METHODS: We retrospectively analyzed the histology of hematoxylin-eosin-stained sections obtained from 96 patients diagnosed with PP, HE, or HHD. RESULTS: The patients were divided into 4 subgroups: PP (n = 16, group A), HE without atopic or nummular dermatitis (n = 41, group B), HE with atopic or nummular dermatitis (n = 14, group C), and HHD (n = 25, group D)...
February 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28187580/mealybugs-hemiptera-coccomorpha-pseudococcidae-with-oral-rim-ducts-description-of-a-new-genus-and-species-from-turkey-and-discussion-of-their-higher-classification-within-the-pseudococcidae
#16
Mehmet Bora Kaydan, Éva Szita
A new monotypic mealybug genus with oral rim ducts, Bromusicoccus Kaydan gen. n. (Hemiptera: Pseudococcidae: Pseudococcinae), is described from Turkey. The higher classification of mealybug genera with oral rim tubular ducts worldwide is discussed and a key is provided to separate them.
February 3, 2017: Zootaxa
https://www.readbyqxmd.com/read/28186795/geometry-driven-folding-of-a-floating-annular-sheet
#17
Joseph D Paulsen, Vincent Démery, K Buğra Toga, Zhanlong Qiu, Thomas P Russell, Benny Davidovitch, Narayanan Menon
Predicting the large-amplitude deformations of thin elastic sheets is difficult due to the complications of self contact, geometric nonlinearities, and a multitude of low-lying energy states. We study a simple two-dimensional setting where an annular polymer sheet floating on an air-water interface is subjected to different tensions on the inner and outer rims. The sheet folds and wrinkles into many distinct morphologies that break axisymmetry. These states can be understood within a recent geometric approach for determining the gross shape of extremely bendable yet inextensible sheets by extremizing an appropriate area functional...
January 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28186622/changes-in-echogenicity-of-hepatic-hemangiomas-during-the-valsalva-maneuver
#18
Hyung Jin Won, Pyo Nyun Kim, Jong Seok Lee
BACKGROUND: We aimed to evaluate changes in echogenicity of hepatic hemangiomas during the Valsalva maneuver. METHODS: We examined 16 liver hemangiomas in 12 patients with a mean diameter of 1.5 cm (range, 0.7-2.2 cm), which showed variations in echogenicity during the Valsalva maneuver. Two radiologists reviewed the sonographic (US) images of the hemangiomas at three different times: prior to the Valsalva maneuver, during the Valsalva maneuver, and on follow-up US examinations...
February 10, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28185146/mr-imaging-features-associated-with-distant-metastasis-free-survival-of-patients-with-invasive-breast-cancer-a-case-control-study
#19
Sung Eun Song, Sung Ui Shin, Hyeong-Gon Moon, Han Suk Ryu, Kwangsoo Kim, Woo Kyung Moon
PURPOSE: Preoperative breast magnetic resonance (MR) imaging features of primary breast cancers may have the potential to act as prognostic biomarkers by providing morphologic and kinetic features representing inter- or intra-tumor heterogeneity. Recent radiogenomic studies reveal that several radiologist-annotated image features are associated with genes or signal pathways involved in tumor progression, treatment resistance, and distant metastasis (DM). We investigate whether preoperative breast MR imaging features are associated with worse DM-free survival in patients with invasive breast cancer...
February 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28185066/optic-disc-rim-and-peripapillary-chorioretinal-atrophy-in-normal-japanese-eyes-the-kumejima-study
#20
Aiko Iwase, Shoichi Sawaguchi, Hiroshi Sakai, Kenji Tanaka, Tae Tsutsumi, Makoto Araie
PURPOSE: To report reference data for optic disc, neuroretinal rim and β-peripapillary atrophy (β-PPA) in normal Japanese. METHODS: In the Kumejima study, all participants underwent disc stereo-photography; 2208 normal subjects had good-quality disc stereo and β-PPA photographs OU. The disc and rim area and the area and angular extent of β-PPA were evaluated by computer-assisted planimetry. RESULTS: The disc, rim, and β-PPA area and its angular extent OD (OS) averaged 2...
February 9, 2017: Japanese Journal of Ophthalmology
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