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https://www.readbyqxmd.com/read/29677701/surgical-treatment-and-long-term-outcome-of-cerebral-cavernous-malformations-related-epilepsy-in-pediatric-patients
#1
Qiao Lin, Peng-Fan Yang, Yan-Zeng Jia, Jia-Sheng Pei, Hui Xiao, Ting-Ting Zhang, Zhong-Hui Zhong, Shou-Sen Wang
Cerebral cavernous malformations (CMs) are vascular malformations affecting any part of the central nervous system. Clinical data and surgical outcomes for 27 pediatric patients with CM-related epilepsy were retrospectively reviewed. The mean age of onset was 12.71 ± 4.09 years, and the mean duration of epilepsy was 2.34 ± 1.95 years. All 27 patients were treated with microsurgery for resection of the CMs, and the hemosiderin rim, and the secondary epileptogenic zone if necessary. The mean follow-up period was 6...
April 20, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29674733/the-use-of-dental-implants-cast-bars-and-sleeve-overdentures-in-oral-cancer-patients
#2
R Ali, A Al-Khayatt, C Barclay
Surgical resection of an oral tumour (and the associated free flap reconstruction) can significantly alter the oral anatomy. The lack of sulcus depth, alveolar ridge, presence of a mobile flap and limited tongue movement can make it impossible for patients to control a removable prosthesis. To help this cohort of patients, dental implants can be invaluable. The Oral Rehabilitation Team at Central Manchester University Dental Hospital have used dental implants to rehabilitate oral cancer patients for over thirty years...
April 20, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29674392/cholesterol-metabolism-promotes-b-cell-positioning-during-immune-pathogenesis-of-chronic-obstructive-pulmonary-disease
#3
Jie Jia, Thomas M Conlon, Rim Sj Sarker, Demet Taşdemir, Natalia F Smirnova, Barkha Srivastava, Stijn E Verleden, Gizem Güneş, Xiao Wu, Cornelia Prehn, Jiaqi Gao, Katharina Heinzelmann, Jutta Lintelmann, Martin Irmler, Stefan Pfeiffer, Michael Schloter, Ralf Zimmermann, Martin Hrabé de Angelis, Johannes Beckers, Jerzy Adamski, Hasan Bayram, Oliver Eickelberg, Ali Önder Yildirim
The development of chronic obstructive pulmonary disease (COPD) pathogenesis remains unclear, but emerging evidence supports a crucial role for inducible bronchus-associated lymphoid tissue (iBALT) in disease progression. Mechanisms underlying iBALT generation, particularly during chronic CS exposure, remain to be defined. Oxysterol metabolism of cholesterol is crucial to immune cell localization in secondary lymphoid tissue. Here, we demonstrate that oxysterols also critically regulate iBALT generation and the immune pathogenesis of COPD In both COPD patients and cigarette smoke (CS)-exposed mice, we identified significantly upregulated CH25H and CYP7B1 expression in airway epithelial cells, regulating CS-induced B-cell migration and iBALT formation...
April 19, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29673260/glaucoma-progression-and-its-relationship-with-corrected-and-uncorrected-intraocular-pressure-in-eyes-with-history-of-refractive-corneal-surgery
#4
Junki Kwon, Kyung Rim Sung, Jaehyuck Jo, Sung Ho Yang
PURPOSE: To investigate glaucoma progression and its relationship with corrected and uncorrected intraocular pressure (IOP) in patients with a history of refractive corneal surgery (RCS). METHODS: Total 56 eyes of 56 primary open-angle glaucoma patients who had a history of RCS were included. Mean keratometry and central corneal thickness were measured at the time of glaucoma diagnosis. Three IOP measurements, i.e., uncorrected IOP (UC IOP) and corrected IOP calculated by applying the Kohlhaas (CK IOP) and Ehlers (CE IOP) formulas, were used...
April 20, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29673173/theoretical-study-of-the-%C3%AE-cyclodextrin-inclusion-complex-formation-of-eugenol-in-water
#5
Elena Alvira
The interaction between eugenol and β-cyclodextrin in the presence of water is studied by molecular mechanics and dynamics simulations. A force field model is used in molecular mechanics to determine the interaction energy and the complex configuration at the absolute minimum. The van der Waals term is the main contribution to the total energy, and so directly determines the configuration of the inclusion complex. The formation of inclusion complexes is simulated by molecular dynamics, in which their configurations are deduced from the position probability density that represents the preferred location and orientation of the guest in the simulation...
April 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29671811/shape-shifted-red-blood-cells-a-novel-red-blood-cell-stage
#6
Verónica Chico, Sara Puente-Marin, Iván Nombela, Sergio Ciordia, María Carmen Mena, Begoña Carracedo, Alberto Villena, Luis Mercado, Julio Coll, María Del Mar Ortega-Villaizan
Primitive nucleated erythroid cells in the bloodstream have long been suggested to be more similar to nucleated red cells of fish, amphibians, and birds than the red cells of fetal and adult mammals. Rainbow trout Ficoll-purified red blood cells (RBCs) cultured in vitro undergo morphological changes, especially when exposed to stress, and enter a new cell stage that we have coined shape-shifted RBCs (shRBCs). We have characterized these shRBCs using transmission electron microscopy (TEM) micrographs, Wright⁻Giemsa staining, cell marker immunostaining, and transcriptomic and proteomic evaluation...
April 19, 2018: Cells
https://www.readbyqxmd.com/read/29669858/the-rna-binding-protein-hfq-is-important-for-ribosome-biogenesis-and-affects-translation-fidelity
#7
José M Andrade, Ricardo F Dos Santos, Irina Chelysheva, Zoya Ignatova, Cecília M Arraiano
Ribosome biogenesis is a complex process involving multiple factors. Here, we show that the widely conserved RNA chaperone Hfq, which can regulate sRNA-mRNA basepairing, plays a critical role in rRNA processing and ribosome assembly in Escherichia coli Hfq binds the 17S rRNA precursor and facilitates its correct processing and folding to mature 16S rRNA Hfq assists ribosome assembly and associates with pre-30S particles but not with mature 30S subunits. Inactivation of Hfq strikingly decreases the pool of mature 70S ribosomes...
April 18, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29665105/optically-unraveling-the-edge-chirality-dependent-band-structure-and-plasmon-damping-in-graphene-edges
#8
Jiahua Duan, Runkun Chen, Yuan Cheng, Tianzhong Yang, Feng Zhai, Qing Dai, Jianing Chen
The nontrivial topological origin and pseudospinorial character of electron wavefunctions make edge states possess unusual electronic properties. Twenty years ago, the tight-binding model calculation predicted that zigzag termination of 2D sheets of carbon atoms have peculiar edge states, which show potential application in spintronics and modern information technologies. Although scanning probe microscopy is employed to capture this phenomenon, the experimental demonstration of its optical response remains challenging...
April 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29664884/biomechanical-testing-of-a-3-hole-versus-a-4-hole-sliding-hip-screw-in-the-presence-of-a-retrograde-intramedullary-nail-for-ipsilateral-intertrochanteric-and-femur-shaft-fractures
#9
Michael Olsen, Peter Goshulak, Meghan C Crookshank, Joel Moktar, Ignace J Brazda, Emil H Schemitsch, Radovan Zdero
OBJECTIVE: The goal of this study was to compare a 3-hole vs. a 4-hole sliding hip screw (SHS) in the presence of a retrograde intramedullary (RIM) nail for fixing intertrochanteric and comminuted midshaft femur fractures. METHODS: Mechanical tests were performed on 10 matched pairs of human cadaveric femurs that were osteotomized and then fixed using a 3-hole SHS vs. the traditional "gold standard" 4-hole SHS in the presence of a RIM nail. RESULTS: Data showed no differences between the 3-hole SHS with RIM nail vs...
April 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29664340/pancreatic-ductal-adenocarcinoma-rim-enhancement-at-mr-imaging-predicts-prognosis-after-curative-resection
#10
Sunyoung Lee, Seong Hyun Kim, Hyung Kyu Park, Kee Taek Jang, Jeong Ah Hwang, Seonwoo Kim
Purpose To identify features at preoperative magnetic resonance (MR) imaging that could predict favorable prognosis after curative resection of pancreatic ductal adenocarcinoma (PDAC). Materials and Methods From January 2009 to December 2014, this retrospective study included 143 patients with surgically resected (ie, R0) PDAC who underwent preoperative MR imaging within 1 month before surgery. Clinical-pathologic and MR imaging findings for predicting disease-free survival (DFS) and overall survival (OS) were identified by using a Cox proportional hazards model...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29662847/impact-of-various-factors-on-color-stability-of-fresh-blueberry-juice-during-storage
#11
Hyo-Nam Song, So-Ae Ji, Hye-Rim Park, Ho-Hyoen Kim, Christer Hogstrand
The attractive purple color of blueberries ( Vaccinium spp.) is unstable and susceptible to degradation during food processing and storage. The effects of various factors on the color stability of fresh blueberry juice were investigated. Total soluble solid content, pH, and total anthocyanin content were measured. Heating at 30°C and 60°C for 300 min did not influence the color stability, but heating at 100°C drastically decreased it by 33.0%. Sugars decreased color in a concentration-dependent manner. However, glucose and galactose had significantly protective effects on the color disruption than fructose, maltose, and sucrose...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29661462/donor-derived-candida-dubliniensis-resulting-in-perigraft-abscesses-in-a-liver-transplant-recipient-proven-by-whole-genome-sequencing-a-case-report
#12
Y E Teh, M L T Ang, M V La, V Gunalan, C K Tan, A L Tan, R T P Lin, T T Tan, P R Jeyaraj, S Cumaraswamy, B H Tan
BACKGROUND: The transmission of fungi via transplant, although well-known, has not often been molecularly proven. We describe a case of donor-derived candidiasis verified by whole genome sequencing. CASE DESCRIPTION: The multiorgan donor was a 42-year-old woman with subdural hemorrhage. Procurement of the thoracic organs was performed followed by the abdominal organs. Tissue from the left bronchus grew Candida dubliniensis. The liver recipient was a 63-year-old woman with cryptogenic liver cirrhosis...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29660175/redox-switchable-calix-6-arene-based-isomeric-rotaxanes
#13
Valeria Zanichelli, Margherita Bazzoni, Arturo Arduini, Paola Franchi, Marco Lucarini, Giulio Ragazzon, Andrea Secchi, Serena Silvi
Operating molecular machines are based on switchable systems, whose components can be set in motion in a controllable fashion. The presence of non-symmetric elements is a mandatory requirement to obtain and demonstrate the unidirectionality of motion. Calixarene-based macrocycles have proven very efficient hosts in the design of oriented rotaxanes and of pseudorotaxanes with a strict control on the direction of complexation. We have synthesized and characterized a series of two-station rotaxanes based on bypiridinium-ammonium axles...
April 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29660062/minimally-invasive-exposure-of-the-maxillary-artery-at-the-anteromedial-infratemporal-fossa
#14
Roberto Rodriguez Rubio, Olivia Kola, Ali Tayebi Meybodi, Halima Tabani, Xuequan Feng, Jan-Karl Burkhardt, Sonia Yousef, Michael T Lawton, Arnau Benet
BACKGROUND: The maxillary artery (MA) has been described as a reliable donor for extracranial-intracranial high-flow bypass. Existing techniques to harvest MA require brain retraction and drilling of the middle fossa (with or without a zygomatic osteotomy), carrying the potential risks of venous bleeding, injury to the branches of the maxillary or mandibular nerves, muscular transection, or temporomandibular junction disorders. OBJECTIVE: To describe a novel technique to expose the MA without bony drilling and with minimal impact to surrounding structures...
April 12, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29659397/scintigraphic-and-sonographic-findings-of-subcapsular-cortical-necrosis-in-a-transplanted-kidney
#15
Bulent Yazici, Emrah Gunay, Aysegül Akgün, Sait Sen, Suha Sureyya Ozbek
Renal transplant scintigraphy, performed in a 23-year-old man who had renal graft from a living donor, showed nearly normal perfusion and moderately low function of the graft. But the margins of the graft were blurred, and it was interestingly appearing enlarged late in the study. Ultrasound demonstrated a hypoechoic rim surrounding the whole kidney. Biopsy revealed necrosis besides normal cortical tissue. Necrosis was thought to be limited to the subcapsular cortical area. It should be considered that these scintigraphic findings could be due to greatly reduced and delayed perfusion of edematous subcapsular necrotic area of the graft even in normal perfusion images...
April 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29659379/bony-reconstruction-of-the-anterior-glenoid-rim
#16
Laurent B Willemot, Bassem T Elhassan, Olivier Verborgt
Recurrent anterior shoulder instability is associated with glenohumeral bone loss. Glenoid deficiency compromises the concavity-compression mechanism. Medial Hill-Sachs lesions can result in an off-track humeral position. Anterior glenoid reconstruction or augmentation prevents recurrence by addressing the pathomechanics. In Bristow and Latarjet procedures, the coracoid process is harvested for conjoint tendon transfer, capsular reinforcement, and glenoid rim restoration. Complications and the nonanatomic nature of the procedure have spurred research on graft sources...
April 13, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29657432/antibacterial-and-antioxidant-activity-of-juniperus-thurifera-l-leaf-extracts-growing-in-east-of-algeria
#17
Merradi Manel, Heleili Nouzha, Mekari Rim, Mekkaoui Imane, Aouachria Sana, Oucheriah Yasmine, Ayachi Ammar
Aim: This work aimed to evaluate the biological activity of the leaf extracts of Juniperus thurifera L., which is an Algerian endemic tree that belongs to the family of Cupressaceae. Materials and Methods: The plant leaves were extracted in solvents of increasing polarity to obtain different extracts such as methanol, petroleum ether, chloroform, ethyl acetate, and aqueous extracts (MeE, PEE, ChlE, EtAE, and AqE). The antioxidant activity of four extracts (MeE, ChlE, EtAE, and AqE) was assessed by trapping test of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29657370/delirium-in-the-intensive-care-unit-incidence-risk-factors-and-impact-on-outcome
#18
Nejla Tilouche, Mohamed Fekih Hassen, Habiba Ben Sik Ali, Oussamma Jaoued, Rim Gharbi, S Souheil El Atrous
Background: The incidence and risk factors for delirium vary among studies. Objective: We aimed to determine the incidence, risk factors, and impact on outcome of delirium in a medical Intensive Care Unit (ICU) in Tunisia using a prospective observational study. Patients: All consecutive patients admitted to the ICU between May 2012 and April 2013 were included if they were aged more than 18 years and had an ICU stay of more than 24 h. Patients who had a cardiac arrest or have a history of dementia or psychosis were excluded...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29655644/long-term-changes-in-anterior-segment-characteristics-of-eyes-with-different-primary-angle-closure-mechanisms
#19
Junki Kwon, Kyung Rim Sung, Seungbong Han
PURPOSE: To assess long-term changes in the anterior segment (AS) of eyes with different angle closure mechanisms. DESIGN: Retrospective cohort study. METHODS: In total, 133 eyes (from 75 participants) with angle closure were enrolled. All eyes received laser iridotomy (LI) during the follow-up period. Serial anterior segment optical coherence tomography (AS-OCT) imaging was performed during a mean follow-up of 4 years. Participants were categorized into four groups according to angle closure mechanisms, based on baseline AS-OCT images: pupillary block (PB), plateau iris configuration (PIC), thick peripheral iris roll (TPIR), and exaggerated lens vault (ELV)...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29655321/-trampoline-ejection-of-organic-molecules-from-graphene-and-graphite-via-kev-cluster-ions-impacts
#20
Stanislav V Verkhoturov, Mikołaj Gołuński, Dmitriy S Verkhoturov, Sheng Geng, Zbigniew Postawa, Emile A Schweikert
We present the data on ejection of molecules and emission of molecular ions caused by single impacts of 50 keV C60 2+ on a molecular layer of deuterated phenylalanine (D8Phe) deposited on free standing, 2-layer graphene. The projectile impacts on the graphene side stimulate the abundant ejection of intact molecules and the emission of molecular ions in the transmission direction. To gain insight into the mechanism of ejection, Molecular Dynamic simulations were performed. It was found that the projectile penetrates the thin layer of graphene, partially depositing the projectile's kinetic energy, and molecules are ejected from the hot area around the hole that is made by the projectile...
April 14, 2018: Journal of Chemical Physics
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