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https://www.readbyqxmd.com/read/28646532/acquired-bilateral-telangiectasia-macularis-eruptiva-perstans-a-unique-clinical-feature-of-photodamaging-rather-than-a-subtype-of-cutaneous-mastocytosis
#1
Hye-Rim Moon, Young Jae Kim, Joon Min Jung, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Sung Eun Chang
Telangiectasia macularis eruptiva perstans (TMEP) is a rare subtype of cutaneous mastocytosis, characterized by telangiectatic tan to brown macules on the trunk and extremities. Although TMEP has been descried as an uncommon disease in the literature, we often encounter patients with TMEP lesions in the outpatient clinic. We aimed to assess the clinical and histopathological characteristics of acquired bilateral TMEP, and the pathophysiological mechanism of acquired bilateral TMEP among these patients. We retrospectively reviewed 30 patients (28 men and 2 women) with acquired bilateral TMEP; multiple telangiectatic dark red to brown macules that were symmetrically distributed...
June 23, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28644577/evidence-of-fuels-management-and-fire-weather-influencing-fire-severity-in-an-extreme-fire-event
#2
Jamie M Lydersen, Brandon M Collins, Matthew L Brooks, John R Matchett, Kristen L Shive, Nicholas A Povak, Van R Kane, Douglas F Smith
Following changes in vegetation structure and pattern, along with a changing climate, large wildfire incidence has increased in forests throughout the western U.S. Given this increase there is great interest in whether fuels treatments and previous wildfire can alter fire severity patterns in large wildfires. We assessed the relative influence of previous fuels treatments (including wildfire), fire weather, vegetation and water balance on fire severity in the Rim Fire of 2013. We did this at three different spatial scales to investigate whether the influences on fire severity changed across scales...
June 23, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28644110/detailed-magnetic-resonance-imaging-features-of-a-case-series-of-primary-gliosarcoma
#3
Luísa Sampaio, Paulo Linhares, José Fonseca
Objective We aimed to characterise the magnetic resonance imaging (MRI) features of a case series of primary gliosarcoma, with the inclusion of diffusion-weighted imaging and perfusion imaging with dynamic susceptibility contrast MRI. Materials and methods We conducted a retrospective study of cases of primary gliosarcoma from the Pathology Department database from January 2006 to December 2014. Clinical and demographic data were obtained. Two neuroradiologists, blinded to diagnosis, assessed tumour location, signal intensity in T1 and T2-weighted images, pattern of enhancement, diffusion-weighted imaging and dynamic susceptibility contrast MRI studies on preoperative MRI...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28642685/rab-interacting-molecules-2-and-3-directly-interact-with-the-pore-forming-cav1-3-ca-2-channel-subunit-and-promote-its-membrane-expression
#4
Maria M Picher, Ana-Maria Oprişoreanu, SangYong Jung, Katrin Michel, Susanne Schoch, Tobias Moser
Rab interacting molecules (RIMs) are multi-domain proteins that positively regulate the number of Ca(2+) channels at the presynaptic active zone (AZ). Several molecular mechanisms have been demonstrated for RIM-binding to components of the presynaptic Ca(2+) channel complex, the key signaling element at the AZ. Here, we report an interaction of the C2B domain of RIM2α and RIM3γ with the C-terminus of the pore-forming α-subunit of CaV1.3 channels (CaV1.3α1), which mediate stimulus-secretion coupling at the ribbon synapses of cochlear inner hair cells (IHCs)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28641150/polyamine-and-tyramine-involvement-in-nacl-induced-improvement-of-cd-resistance-in-the-halophyte-inula-chrithmoides-l
#5
Rim Ghabriche, Tahar Ghnaya, Mejda Mnasri, Hanen Zaier, Raoudha Baioui, Delphine Vromman, Chedly Abdelly, Stanley Lutts
The aim of the present work was to analyze the impact of salinity on the plant response to Cd toxicity in the Mediterranean halophyte species Inula crithmoides. For this purpose, cuttings were cultivated hydroponically during 21d in the presence of 0, 25 or 50μM CdCl2 combined or not with 0, 100, 200 and 400mM NaCl. The obtained data demonstrated that, in the absence of Cd, NaCl strongly increased plant growth (the maximal dry weight being observed at 100mM) and enhanced the Na(+)/K(+) ratio in the shoot. Cd alone strongly affected plant growth in this halophyte...
June 6, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28639203/development-of-therapeutic-dsp21-322-for-cancer-treatment
#6
Moo Rim Kang, Gongcheng Li, Tiejun Pan, Jin-Chun Xing, Long-Cheng Li
Small activating RNAs (saRNAs) are a class of artificially designed short duplex RNAs targeted at the promoter of a particular gene to upregulate its expression via a mechanism known as RNA activation (RNAa) and hold great promise for treating a wide variety of diseases including those undruggable by conventional therapies. The therapeutic benefits of saRNAs have been demonstrated in a number of preclinical studies carried out in different disease models including cancer. With many tumor suppressor genes (TSGs) downregulated due to either epigenetic mechanisms or haploinsufficiency resulting from deletion/mutation, cancer is an ideal disease space for saRNA therapeutics which can restore the expression of TSGs via epigenetic reprogramming...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28638266/nuclear-expression-of-gs28-protein-a-novel-biomarker-that-predicts-prognosis-in-colorectal-cancers
#7
Sung Hak Lee, Hyung Jae Yoo, Do Eun Rim, Yinji Cui, Ahwon Lee, Eun Sun Jung, Seung Taek Oh, Jun Gi Kim, Oh-Joo Kwon, Su Young Kim, Seong-Whan Jeong
Aims: GS28 (Golgi SNARE protein, 28 kDa), a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) protein family, plays a critical role in mammalian endoplasmic reticulum (ER)-Golgi or intra-Golgi vesicle transport. To date, few researches on the GS28 protein in human cancer tissues have been reported. In this study, we assessed the prognostic value of GS28 in patients with colorectal cancer (CRC). Methods and results: We screened for GS28 expression using immunohistochemistry in 230 surgical CRC specimens...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28637995/intracranial-bony-canal-of-the-middle-meningeal-artery-morphological-and-histological-analysis
#8
Michio Fujimoto, Naruhito Otsuka, Hiromitsu Ezure, Hiroshi Moriyama, Yuriko Inoue, Ryoichi Mori
The middle meningeal artery (MMA) can play an important role in the surgical revascularization. However, the MMA can be easily injured if it passes through a bony canal. We investigated the morphological and histological features of the bony canal to improve surgical results. MATERIALS AND METHODS: Fifty adult dry skulls were investigated. The length of the bony canal and the distance from the orbital rim to the bony canal were measured. Additionally, 28 cadaveric heads were examined histologically...
2017: Okajimas Folia Anatomica Japonica
https://www.readbyqxmd.com/read/28635290/bare-and-effective-charge-of-mesoporous-silica-particles
#9
Sabrina Valetti, Adam Feiler, Martin Trulsson
We develop and combine a novel numerical model, within the Poisson-Boltzmann frame- work, with classical experimental titration techniques for mesoporous silica particles to study the charging behavior as both pH and the amount of monovalent salt are varied. One key finding is that these particles can be considered to have an effectively or apparent electroneutral inner core with an effectively charged rim. As a consequence, the total apparent charge of the particle is several orders of magnitude smaller than that of the bare silica charge, which accounts only for the charged silanol groups of the mesoporous silica particles and which has its major contribution from the interior...
June 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28634405/shedding-new-light-on-an-old-molecule-quinophthalone-displays-uncommon-n-to-o-excited-state-intramolecular-proton-transfer-esipt-between-photobases
#10
Gi Rim Han, Doyk Hwang, Seunghoon Lee, Jong Woo Lee, Eunhak Lim, Jiyoung Heo, Seong Keun Kim
Excited state dynamics of common yellow dye quinophthalone (QPH) was probed by femtosecond transient absorption spectroscopy. Multi-exponential decay of the excited state and significant change of rate constants upon deuterium substitution indicate that uncommon nitrogen-to-oxygen excited state intramolecular proton transfer (ESIPT) occurs. By performing density functional theory (DFT) and time-dependent density functional theory (TDDFT) calculations, we found that adiabatic surface crossing between the S1 and S2 states takes place in the photoreaction...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634057/evaluation-of-the-biotechnological-potential-of-a-novel-purified-protease-bs1-from-bacillus-safensis-s406-on-the-chitin-extraction-and-detergent-formulation
#11
Samiha Mhamdi, Intidhar Bkhairia, Rim Nasri, Tahar Mechichi, Moncef Nasri, Alya Sellami Kamoun
The aim of this study is the production of High-Added Value enzyme for Industrial Uses. An extracellular alkaline stable protease BS1 was purified from a newly bacterium, Bacillus safensis S406, isolated from the Sfax Solar Saltern. BS1 was purified by a process involving sulfate d'ammonium sulfate precipitation, sephadex G-75, Mono-Q anion-exchange chromatography and ultrafiltation. The enzyme has a molecular weight of 24kDa and appeared as a single band on native-PAGE. The optimum pH and temperature values of its proteolytic activity were pH 11...
June 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28633478/efficacy-of-3d-transoesophageal-echocardiography-for-transcatheter-device-closure-of-atrial-septal-defect-without-balloon-sizing
#12
Jeong Yoon Jang, Ran Heo, Min Soo Cho, Jaeseok Bae, Jung Ae Hong, Sahmin Lee, Jung-Min Ahn, Duk-Woo Park, Dae-Hee Kim, Duk-Hyun Kang, Jae-Kwan Song, Jong-Min Song
Aims: Using balloon sizing to determine device size may cause complications and increase procedure time in performing transcatheter closure of atrial septal defect (ASD). We aimed to validate the clinical utility of a formula using measurements from 3D transoesophageal echocardiography (TOE) images in performing the procedure without balloon sizing. Methods and results: We enrolled 248 consecutive patients with ASD in a prospective registry. In the first tier (n = 53), we determined the device size before the procedure using our formula and performed balloon sizing during the procedure to verify our decision...
June 19, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28632546/clinical-outcome-and-postoperative-ct-measurements-of-microendoscopic-decompression-for-lumbar-spinal-stenosis
#13
Xu Zhou, Lei Zhang, Hai-Long Zhang, Shi-Sheng He, Xin Gu, Guang-Fei Gu, Qing-Song Fu
STUDY DESIGN: This was a retrospective case series. OBJECTIVE: To retrospectively evaluate the clinical outcome of microendoscopic decompression for lumbar spinal stenosis (LSS) including an evaluation of the extent of decompression using computed tomography. SUMMARY OF BACKGROUND DATA: Microendoscopic decompression has been a widely applied procedure to treat LSS with satisfactory outcomes and comparatively fewer complications and revision...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28632496/clustering-of-chronic-diseases-risk-factors-among-adolescents-a-quasi-experimental-study-in-sousse-tunisia
#14
Emna Dendana, Rim Ghammem, Jihene Sahli, Jihen Maatoug, Sihem Ben Fredj, Imed Harrabi, Molka Chaieb, Hassen Ghannem
Background The objective of the study was to evaluate the effectiveness of a school-based physical activity and nutritional behavior intervention, on the reduction of clustering of chronic diseases risk factors among school children. Materials and methods A quasi-experimental school-based intervention was conducted with an intervention group and a control group in the region of Sousse in Tunisia. The intervention was implemented between 2010 and 2013, with data collected at pre and at post intervention. Studied risk factors were: smoking, sedentary behavior, low fruit and vegetable intake and obesity...
June 21, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28632251/effects-of-nurse-led-telephone-based-supportive-interventions-for-patients-with-cancer-a-meta-analysis
#15
Soon-Rim Suh, Myung Kyung Lee
PROBLEM IDENTIFICATION: To evaluate the effects of nurse-led telephone-based supportive interventions (NTSIs) for patients with cancer.
. LITERATURE SEARCH: Electronic databases, including EMBASE®, MEDLINE, Google Scholar, 
Cochrane Library CENTRAL, ProQuest Medical Library, and CINAHL®, were searched through February 2016.
. DATA EVALUATION: 239 studies were identified; 16 were suitable for meta-analysis. Cochrane's risk of bias tool and the Comprehensive Meta-Analysis software were used...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28630753/how-to-deal-with-a-glenoid-fracture
#16
Lars Henrik Frich, Morten Schultz Larsen
The glenoid fossa is involved in approximately 10% of all scapular fractures.Glenoid fossa incongruity is surprisingly well tolerated.Surgery is recommended when 20% or more of the anterior glenoid fossa is involved.Glenoid rim fractures often lead to chronic shoulder instability.Unstable glenoid neck fractures need surgical treatment and stable fractures can be treated conservatively.CT examination with 3D reformations of the glenoid fossa has improved insight into fracture morphology and fracture patterns and is very helpful for clinical decision makers...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28630735/arthroscopic-acetabuloplasty-without-labral-detachment-for-focal-pincer-type-impingement-a-minimum-2-year-follow-up
#17
Fernando M Comba, Pablo A Slullitel, Pedro Bronenberg, Gerardo Zanotti, Martin A Buttaro, Francisco Piccaluga
In order to access and resect the acetabular rim, arthroscopic acetabuloplasty was described with labral detachment. When the chondrolabral junction remains intact, acetabuloplasty and labral refixation can be performed maintaining an unharmed labrum. We aimed to evaluate the outcome of a group of patients treated with arthroscopic acetabuloplasty without labral detachment. During the study period, we retrospectively analysed 44 patients with pincer-type o combined impingement and an intact chondroblabral junction, with an average follow-up of 32 months (range: 27-38)...
July 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630729/acetabular-rim-length-an-anatomical-study-to-determine-reasonable-graft-sizes-for-labral-reconstruction
#18
Michael R Karns, Sunny H Patel, Jensen Kolaczko, Raymond W Liu, Richard C Mather, Brian J White, Shane J Nho, Michael J Salata
The purpose of this article is to determine normative values for the length of the acetabular rim and detect differences between gender, age, ethnicity, height and leg length. Six measurements were taken on the acetabular rim of 143 cadaveric skeleton specimens (286 acetabula) using a coordinate-measuring device: circumferential (excluding acetabular notch), anterior inferior iliac spine (AIIS)-anterior, AIIS-posterior, 12-3 o'clock, 12-9 o'clock and 11-5 o'clock. Museum specimen height data and leg length data from a previous study were recorded for 109 of 143 specimens...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630534/data-sharing-a-new-editorial-initiative-of-the-international-committee-of-medical-journal-editors-implications-for-the-editors-network
#19
Fernando Alfonso, Karlen Adamyan, Jean-Yves Artigou, Michael Aschermann, Michael Boehm, Alfonso Buendia, Pao-Hsien Chu, Ariel Cohen, Livio Dei Cas, Mirza Dilic, Anton Doubell, Dario Echeverri, Nuray Enç, Ignacio Ferreira-González, Krzysztof J Filipiak, Andreas Flammer, Eckart Fleck, Plamen Gatzov, Carmen Ginghina, Lino Goncalves, Habib Haouala, Mahmoud Hassanein, Gerd Heusch, Kurt Huber, Ivan Hulín, Mario Ivanusa, Rungroj Krittayaphong, Chu-Pak Lau, Germanas Marinskis, François Mach, Luiz Felipe Moreira, Tuomo Nieminen, Latifa Oukerraj, Stefan Perings, Luc Pierard, Tatjana Potpara, Walter Reyes-Caorsi, Se-Joong Rim, Olaf Rødevand, Georges Saade, Mikael Sander, Evgeny Shlyakhto, Bilgin Timuralp, Dimitris Tousoulis, Dilek Ural, J J Piek, Albert Varga, Thomas F Lüscher
The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship- emphasizing the importance of responsibility and accountability-, have been proposed...
May 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28630304/transitional-turbulent-spots-and-turbulent-turbulent-spots-in-boundary-layers
#20
Xiaohua Wu, Parviz Moin, James M Wallace, Jinhie Skarda, Adrián Lozano-Durán, Jean-Pierre Hickey
Two observations drawn from a thoroughly validated direct numerical simulation of the canonical spatially developing, zero-pressure gradient, smooth, flat-plate boundary layer are presented here. The first is that, for bypass transition in the narrow sense defined herein, we found that the transitional-turbulent spot inception mechanism is analogous to the secondary instability of boundary-layer natural transition, namely a spanwise vortex filament becomes a [Formula: see text] vortex and then, a hairpin packet...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
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