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Erik F Kot, Alexander Sergeevich Arseniev, Konstantin S Mineev
Isotropic bicelles are a widely used membrane mimetic for structural studies of membrane proteins and their transmembrane domains. Simple and cheap in preparation, they contain a patch of lipid bilayer that reproduces the native environment of membrane proteins. Despite the obvious power of bicelles in reproducing the various kinds of environments, the vast majority of structural studies employ the single lipid/detergent system. On the other hand, even if the alternative bicelle composition is used, the properties of mixtures are not characterized and the mere presence of lipid bilayer and discoidal shape of bicelle particles is not confirmed...
June 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Bohyun Kim, Jei Hee Lee, Jai Keun Kim, Hye Jin Kim, Young Bae Kim, Dakeun Lee
This study aimed to evaluate the capability of gadoxetic acid-enhanced MR (GAeMR) to detect presence of capsule appearance in hepatocellular carcinoma (HCC), and to correlate it with dynamic computed tomography (CT) and pathological features.Sixty-three patients (54: 9 = M: F, mean age 55.8) surgically confirmed HCCs with preoperative CT and GAeMR were included in this retrospective study. Two readers evaluated presence of capsule appearances on CT and GAeMR images in each phase including precontrast (Pre), portal phase (PP), delayed phase (DP), transitional phase (TP), and hepatobiliary phase (HBP)...
June 2018: Medicine (Baltimore)
Inbar Horin, Tal Adiri, Yossi Zafrani, Yoram Cohen
Bis-resorcin[4]arene 2 connected by its lower rims was synthesized via click chemistry and found, by diffusion NMR, to self-assemble quantitatively, despite the different alternatives, into hexameric capsules reminiscent of the well-characterized hexameric capsule of resorcin[4]arene 1. The hexameric capsules of the flexible bis-resorcin[4]arene 2 prevail in apolar organic solvents and can, as expected, encapsulate quite well ammonium salts, demonstrating that spontaneous self-assembly into hexameric capsules is a general characteristic of such systems...
June 20, 2018: Organic Letters
Ji Soo Song, Eun Jung Choi, Seung Bae Hwang, Hong Pil Hwang, HyeMi Choi
OBJECTIVES: To use Liver Imaging Reporting and Data System (LI-RADS) categorization and features of hepatocellular carcinomas (HCCs) to intraindividually compare gadopentetate dimeglumine-enhanced magnetic resonance imaging (Gd-DTPA-MRI) and gadoxetic acid-enhanced MRI (Gd-EOB-MRI), before and after applying modified major features. METHODS: Of 77 HCCs in 64 patients analysed, 17 HCCs were confirmed histopathologically and 46 patients had cirrhosis. Gd-EOB-MRI and Gd-DTPA-MRI were evaluated for the presence of major and ancillary features by two radiologists...
June 19, 2018: European Radiology
Layth Al Attar, Aarati Keshary, Raid Abu-Awwad
Radiologic findings are important in narrowing differential diagnosis. This becomes imperative in unusual presentation of diseases. An uncommon finding on lung imaging is Cheerios signs. It is described as lesions with hypodense center and noticeable rim. These lesions are associated with bronchioloalveolar carcinoma representing lepidic growth. We present a case of rapidly worsening shortness breath and cough. Initial computed tomography scan of the chest showed cystic lesions on ground glass background in both lungs...
April 17, 2018: Curēus
Tae Ho Kim, Seok Joo Kang, Hook Sun
Background: The ideal absorbable plating system should provide sufficient rigidity and then be absorbed within a timely manner. The Resorb-X has been recently developed as a plating system with a mixture ratio of 50:50 poly(D, L-lactide). Methods: : We present seven of 121 patients who experienced delayed degradation with this absorbable plate. One hundred twenty-one patients with facial bone fracture underwent surgical treatment from March 2011 to March 2015, and rigid fixation was achieved with the Resorb-X...
June 20, 2018: Archives of Craniofacial Surgery
Daiki Kakiuchi, Kenichiro Saito, Takeshi Mitsui, Yoshinori Munemoto, Yoshihiro Takashima, Susumu Amaya, Masanari Shimada, Yosuke Kato
A 75-year-old woman underwent laparoscopic abdominoperineal resection. Four months after abdominoperineal resection, the patient complained of a perineal bulge and urination disorder. Abdominal CT showed protrusion of the small intestine and bladder to the perineum. The patient underwent laparoscopic hernia repair with mesh. The size of the hernial orifice was 7.0 × 9.0 cm, and it had no solid rim. The mesh was tacked ventrally to the pectineal ligament and dorsally to the sacrum, and then sutured on the lateral side...
June 19, 2018: Asian Journal of Endoscopic Surgery
Hye-Rim Won, Hyun-Wook Ryu, Dong-Hee Shin, Soo-Keun Yeon, Dong Hoon Lee, So Hee Kwon
Although histone deacetylase inhibitors (HDACi) alone could be clinically useful, these are most recently used in combination with other anticancer agents in clinical trials for cancer treatment. Recently, we reported the anticancer activity of an HDAC6-selective inhibitor A452 towards various cancer cell types. This study aims to present a potent synergistic antiproliferative effect of A452/anticancer agent treatment in colorectal cancer cells (CRC) cells, independently of the p53 status. A452 in combination with irinotecan, or SAHA is more potent than either drug alone in the apoptotic pathway as evidenced by activated caspase-3 and PARP, increased Bak and pp38, decreased Bcl-xL, pERK and pAKT, and induced apoptotic cells...
June 19, 2018: Molecular Carcinogenesis
Koosha Ramezani, Iván Marín-Franch, Rongrong Hu, William H Swanson, Lyne Racette
PURPOSE: The purpose of this study was to determine whether combining a structural measure with contrast sensitivity perimetry (CSP), which has lower test-retest variability than static automated perimetry (SAP), reduces prediction error with two models of glaucoma progression. METHODS: In this retrospective analysis, eyes with 5 visits with rim area (RA), SAP and CSP measures were selected from two datasets. Twenty-six eyes with open-angle glaucoma were included in the analyses...
June 18, 2018: Journal of Glaucoma
Jae-Rim Heo, Soo-Min Kim, Kyung-A Hwang, Ji-Houn Kang, Kyung-Chul Choi
Resveratrol, a dietary product present in grapes, vegetables and berries, regulates several signaling pathways that control cell division, cell growth, apoptosis and metastasis. Malignant melanoma proliferates more readily in comparison with any other types of skin cancer. In the present study, the anti‑cancer effect of resveratrol on melanoma cell proliferation was evaluated. Treating A375SM cells with resveratrol resulted in a decrease in cell growth. The alteration in the levels of cell cycle‑associated proteins was also examined by western blot analysis...
June 15, 2018: International Journal of Molecular Medicine
Jung Hwan Lee, Da Hea Seo, Min Jung Nam, Geon Hui Lee, Dong Hee Yang, Min Joo Lee, Ung-Rim Choi, Seongbin Hong
Background: Obesity and related metabolic disorders are growing health challenges worldwide and individuals at military service are not exceptions. The purpose of this study was to examine the prevalence of obesity and metabolic syndrome (MS) in the Korean military and to compare with the general population. Methods: This was a cross-sectional study of 4,803 young military participants who underwent a corporal health-screening program between October 2013 and October 2014...
June 18, 2018: Journal of Korean Medical Science
Shahzad I Mian, Anthony J Aldave, Elmer Y Tu, Brandon D Ayres, Bennie H Jeng, Marian S Macsai, Michael L Nordlund, Jeffrey G Penta, Sudeep Pramanik, Loretta B Szczotka-Flynn, Allison R Ayala, Wendi Liang, Maureen G Maguire, Jonathan H Lass
PURPOSE: To assess donor rim culture results and outcomes of ocular infections in the Cornea Preservation Time Study (CPTS). METHODS: Donor corneal rim cultures were optional. Donor characteristics were assessed for association with positive cultures using the Fisher exact test and Poisson regression analyses. Incidence rates of ocular infections were estimated, and 95% confidence intervals were calculated. RESULTS: Cultures were performed in 784 (58...
June 14, 2018: Cornea
Lobna Ben Mahmoud, Moez Mdhaffar, Rim Frikha, Hanen Ghozzi, Ahmed Hakim, Zouheir Sahnoun, Moez Elloumi, Khaled Zeghal
BACKGROUND: Methotrexate (MTX) is a key component of acute lymphoblastic leukemia (ALL) therapy, but it is associated with serious toxicities in a considerable number of patients. OBJECTIVES: The aim of the current study was to determine which variables were associated with MTX toxicity in children, adolescents and young adults with ALL. MATERIAL AND METHODS: In this prospective study, 35 patients with newly diagnosed ALL, treated according to the 58951 European Organization for Research and Treatment of Cancer - Children's Leukemia Group (EORTC-CLG) protocol, were prospectively enrolled...
June 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Marcos Daou, Keith R Lohse, Matthew W Miller
The reflective⁻impulsive model (RIM) has been employed to explain various health behaviors. The present study used RIM to predict a spontaneous physical activity behavior. Specifically, 107 participants (75 females; Mage = 20.6 years, SD = 1.92 years) completed measures of (1) reflections about spontaneous physical activity, as indexed by self-report questionnaire; (2) impulse toward physical activity, as indexed by the manikin task; and (3) (state) self-control, as indexed by the Stroop task. The dependent variable was whether participants took the stairs or the elevator to the study laboratory...
September 29, 2017: Sports
Jian Zheng, Hong Zhang, Chun Wang
BACKGROUND: Intradiploic epidermoid cyst (IEC) concurrent with chronic epidural hematoma (CEDH) has never been reported in the literature. We report a unique case of IEC concurrent with anatomically close associated CEDH. CASE DESCRIPTION: A 54-year-old man presented with one week history of headache, confusion and drowsiness. Computed tomography (CT) exposed large extraaxial mixed density lesions with bone destruction and substantial mass effect in the left fronto-temporal region...
June 14, 2018: World Neurosurgery
Andrea Grandoch, Matthias Kreppel, Ali-Farid Safi, Matthias Zirk, Joachim E Zöller
PURPOSE: Fractures of the orbital floor and orbital rim are frequently treated in maxillofacial departments. Various approaches to the orbital floor are described in the literature. We present an investigation of a modified subciliary approach (laterocaudal approach) with respect to its feasibility and clinical outcome. MATERIALS AND METHODS: Our retrospective study investigated 130 well-documented cases of patients with orbital floor fractures who received surgical reconstruction using a laterocaudal approach, and compared the results with the current literature, with a focus on subciliary and transconjunctival approaches...
April 18, 2018: Journal of Cranio-maxillo-facial Surgery
Sasan Moghimi, Linda M Zangwill, Rafaella C Penteado, Kyle Hasenstab, Elham Ghahari, Huiyuan Hou, Mark Christopher, Adeleh Yarmohammadi, Patricia Isabel C Manalastas, Takuhei Shoji, Christopher Bowd, Robert N Weinreb
PURPOSE: To investigate prospectively the relationship between macular and peripapillary vessel density and progressive retinal nerve fiber layer (RNFL) loss in patients with mild to moderate primary open-angle glaucoma. DESIGN: Prospective, observational study. PARTICIPANTS: One hundred thirty-two eyes of 83 patients with glaucoma followed up for at least 2 years (average: 27.3±3.36 months). METHODS: Measurements of macular whole image vessel density (m-wiVD) and optic nerve head whole image vessel density (onh-wiVD) were acquired at baseline using OCT angiography...
June 12, 2018: Ophthalmology
Yaxing Li, Pengyu Lv, Christian Diddens, Huanshu Tan, Herman Wijshoff, Michel Versluis, Detlef Lohse
Droplet evaporation of multicomponent droplets is essential for various physiochemical applications, e.g., in inkjet printing, spray cooling, and microfabrication. In this work, we observe and study the phase segregation of an evaporating sessile binary droplet, consisting of a miscible mixture of water and a surfactantlike liquid (1,2-hexanediol). The phase segregation (i.e., demixing) leads to a reduced water evaporation rate of the droplet, and eventually the evaporation process ceases due to shielding of the water by the nonvolatile 1,2-hexanediol...
June 1, 2018: Physical Review Letters
J H Lewey, T M Kivisalu, L Giromini
The Rorschach Inkblot Method (RIM) is a performance-based personality assessment instrument used in both clinical and research settings worldwide. This investigation examines response-level, interrater reliability of U.S. graduate students enrolled in the same doctoral program and divided into two unique participant groups: 20 of those with previous Comprehensive System (CS) training background who are now trained in Rorschach Performance Assessment System (R-PAS; initial coders N = 11, blind coders N = 9), and 19 of those trained solely with R-PAS (initial coders N = 10, blind coders N = 9)...
June 14, 2018: Journal of Personality Assessment
Réka Lukács, Marcel Guillong, Axel K Schmitt, Kata Molnár, Olivier Bachmann, Szabolcs Harangi
This article provides laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and secondary ionization mass spectrometry (SIMS) U-Pb and U-Th zircon dates for crystals separated from Late Pleistocene dacitic lava dome rocks of the Ciomadul Volcanic Dome Complex (Eastern Carpathians, Romania). The analyses were performed on unpolished zircon prism faces (termed rim analyses) and on crystal interiors exposed through mechanical grinding an polishing (interior analyses). 206 Pb/238 U ages are corrected for Th-disequilibrium based on published and calculated distribution coefficients for U and Th using average whole-rock and individually analyzed zircon compositions...
June 2018: Data in Brief
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