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https://www.readbyqxmd.com/read/29040280/quantitative-analysis-of-neural-tissues-around-the-optic-disc-after-panretinal-photocoagulation-in-patients-with-diabetic-retinopathy
#1
Hyun Seung Yang, June-Gone Kim, Jae Bong Cha, Young In Yun, Jong Hoon Park, Jong Eun Woo
In this retrospective cross-sectional study, we quantitatively analyzed the tomographic features in the neural tissues around the optic disc in patients with diabetic retinopathy with and without panretinal photocoagulation. We analyzed 206 eyes, comprising 33 normal eyes in subjects without diabetes (group I), 30 eyes without diabetic retinopathy (group II), 66 eyes with non-proliferative diabetic retinopathy (group III), 45 eyes with panretinal photocoagulation (group IV), and 32 eyes with normal tension glaucoma (group V)...
2017: PloS One
https://www.readbyqxmd.com/read/29040005/the-shape-of-vesicle-containing-organelles-is-critical-for-their-functions-in-vesicle-endocytosis
#2
Chelsea M Winters, Ly Q Hong-Brown, Hui-Ling Chiang
Exosomes are small vesicles secreted by a variety of cell types under physiological and pathological conditions. When Saccharomyces cerevisiae are grown in low glucose, small vesicles carrying more than 300 proteins with diverse biological functions are secreted. Upon glucose addition, secreted vesicles are endocytosed that requires cup-shaped organelles containing the major eisosome protein Pil1p at the rims. We aim to identify genes that regulate the function of cup-shaped organelles in vesicle endocytosis...
October 17, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/29036137/design-of-a-broadband-hemispherical-wave-collimator-lens-using-the-ray-inserting-method
#3
Mohammad Mahdi Taskhiri, Mohammad Khalaj Amirhosseini
This paper presents a novel inhomogeneous hemispherical dielectric lens. The proposed lens is designed based on the ray inserting method (RIM). Applying this approach, a uniform distribution of the rays' end points over the lens plane aperture is achieved while lens matching to the environment refractive index is perfectly fulfilled. We can change the antenna features such as sidelobe level and gain by controlling the end point of each ray propagated through the hemispherical lens. The refractive index of the designed hemispherical inhomogeneous lens is derived and it is validated using COMSOL Multiphysics...
July 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035615/improving-mobility-performance-in-wheelchair-basketball
#4
Thom T J Veeger, Annemarie M H De Witte, Monique A M Berger, Rienk M A Van Der Slikke, Dirkjan H E J Veeger, Marco J M Hoozemans
OBJECTIVE: This study aimed to investigate which characteristics of athlete, wheelchair and athlete-wheelchair interface are the best predictors of wheelchair basketball mobility performance. DESIGN: Sixty experienced wheelchair basketball players performed a wheelchair mobility performance test to assess their mobility performance. To determine which variables were the best predictors of mobility performance, forward stepwise linear regression analyses were performed on a set of 33 characteristics, including ten athlete, nineteen wheelchair and four athlete-wheelchair interface characteristics...
October 16, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29034814/entomophthoromycosis-and-mucormycosis-as-causes-of-pneumonia-in-vietnamese-potbellied-pigs
#5
Dawn E Evans, Atsushi Kawabata, Leslie D Wilson, Kenneth Kim, Shannon D Dehghanpir, Steve D Gaunt, Matt Welborn, Britton Grasperge, Marjorie S Gill
Two Vietnamese potbellied pigs ( Sus scrofa) had respiratory disease and, on autopsy, both pigs had large masses in the lungs and thoracic cavity. Microscopically, pulmonary and pleural masses contained large areas with hyphae surrounded by hypereosinophilic cellular debris rimmed by abundant eosinophils, lymphocytes, plasma cells, and histiocytes with occasional multinucleate giant cells. The hypereosinophilic debris usually formed tight cuffs, or "sleeves" around the hyphae, compatible with Splendore-Hoeppli-like material...
October 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29033205/differential-regulation-of-evoked-and-spontaneous-release-by-presynaptic-nmda-receptors
#6
Therése Abrahamsson, Christina You Chien Chou, Si Ying Li, Adamo Mancino, Rui Ponte Costa, Jennifer Anne Brock, Erin Nuro, Katherine Anne Buchanan, Dale Elgar, Arne Vladimir Blackman, Adam Tudor-Jones, Julia Oyrer, William Todd Farmer, Keith Kazuo Murai, Per Jesper Sjöström
Presynaptic NMDA receptors (preNMDARs) control synaptic release, but it is not well understood how. Rab3-interacting molecules (RIMs) provide scaffolding at presynaptic active zones and are involved in vesicle priming. Moreover, c-Jun N-terminal kinase (JNK) has been implicated in regulation of spontaneous release. We demonstrate that, at connected layer 5 pyramidal cell pairs of developing mouse visual cortex, Mg(2+)-sensitive preNMDAR signaling upregulates replenishment of the readily releasable vesicle pool during high-frequency firing...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/29032823/bortezomib-facilitates-reparative-dentin-formation-after-pulp-access-cavity-preparation-in-mouse-molar
#7
Jae-Kwang Jung, Gi-Jeong Gwon, Sanjiv Neupane, Wern-Joo Sohn, Ki-Rim Kim, Ji-Youn Kim, Seo-Young An, Tae-Yub Kwon, Chang-Hyeon An, Youngkyun Lee, Jae-Young Kim, Jung-Hong Ha
INTRODUCTION: The aim of this study was to evaluate in vitro and ex vivo roles of bortezomib, a proteasome inhibitor that binds to the active site of the 26S proteasome, in tertiary dentin formation. METHODS: We established pulpal access cavity preparation that was treated with or without bortezomib before direct pulp capping with a calcium hydroxide-based material. We also analyzed bone morphogenetic protein (Bmp)- and Wnt-related signaling molecules using quantitative real-time polymerase chain reaction...
October 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29032589/microscopic-assessment-of-the-tissue-sparing-potential-of-radiofrequency-assisted-liver-resection-techniques-in-a-porcine-model
#8
Petros Ypsilantis, Maria Lambropoulou, Miroslav Milicevic, Predrag Bulajic, Anastasios Karayiannakis, Dimitrios Zacharoulis, Constantinos Simopoulos
BACKGROUNG/PURPOSE: To microscopically assess the tissue-sparing potential of contemporary radiofrequency-assisted liver resection (RF-LR) techniques. METHODS: Twenty four pigs were subjected to either a) partial hepatectomy (PH) employing the sequential-coagulate-cut (SCC) technique (group SCC, n=6) using a monopolar electrode, the technique using the bipolar electrode Habib-4X (group H, n=6) or the "crush-clamp" technique (group CC, n=6) or b) sham operation (group Sham, n=6)...
October 15, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29032358/a-rim-and-spoke-hypothesis-to-explain-the-biomechanical-roles-for-cytoplasmic-intermediate-filament-networks
#9
REVIEW
Roy A Quinlan, Nicole Schwarz, Reinhard Windoffer, Christine Richardson, Tim Hawkins, Joshua A Broussard, Kathleen J Green, Rudolf E Leube
Textbook images of keratin intermediate filament (IF) networks in epithelial cells and the functional compromization of the epidermis by keratin mutations promulgate a mechanical role for this important cytoskeletal component. In stratified epithelia, keratin filaments form prominent radial spokes that are focused onto cell-cell contact sites, i.e. the desmosomes. In this Hypothesis, we draw attention to a subset of keratin filaments that are apposed to the plasma membrane. They form a rim of filaments interconnecting the desmosomes in a circumferential network...
October 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29031904/definitive-radiotherapy-for-a-head-and-neck-merkel-cell-carcinoma-and-comprehensive-nodal-volumes-a-case-for-using-a-computer-designed-variable-thickness-compensator-to-reduce-risk-and-severity-of-mucositis
#10
Anesa Ahamad, Donald T Weed, Darel D Pruett, Daniel Saulpaugh, Womah Neeranjun, Eduardo Fernandez
When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1.5 cm lateral to the orbital rim, we were challenged to deliver 50 Gy to comprehensive elective nodal regions and 70 Gy to the primary. We were particularly concerned about the potential adverse acute effects of radiotherapy to mucosal structures in this elderly female...
October 11, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29029595/2-hydroxyoleic-acid-inserted-liposomes-as-a-multifunctional-carrier-of-anticancer-drugs
#11
Eun-Ji Jang, Woo Rim Choi, Soo-Yeon Kim, Soon-Seok Hong, Inmoo Rhee, Sang-Jin Lee, Sung Weon Choi, Han-Gon Choi, Soo-Jeong Lim
Studies have shown that insertion of oleic acid into lipid bilayers can modulate the membrane properties of liposomes so as to improve their function as drug carriers. Considering that 2-hydroxyoleic acid (2OHOA), a potential antitumor agent currently undergoing clinical trials, is a derivative of oleic acid, we explored the possibility of developing 2OHOA-inserted liposomes as a multifunctional carrier of antitumor drugs in the present study. The insertion of 2OHOA into lipid bilayers was confirmed by surface charge determination and differential scanning calorimetry...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29028672/birth-cohort-consortium-of-asia-current-and-future-perspectives
#12
Reiko Kishi, Jun Jim Zhang, Eun-Hee Ha, Pau-Chung Chen, Ying Tian, Yankai Xia, Kenji J Tsuchiya, Kunihiko Nakai, Sungkyoon Kim, Soo-Jong Hong, Yun-Chul Hong, Jeong-Rim Lee, Hamid Jan B Jan Mohamed, Rajendra Prasad Parajuli, Linda S Adair, Yap Seng Chong, Yue Leon Guo, Shu-Li Wang, Muneko Nishijo, Teruhiko Kido, Pham The Tai, Sumal Nandasena
BACKGROUND: The environmental health of children is one of the great global health concerns. Exposures in utero and throughout development can have major consequences on later health. However, environmental risks or disease burdens vary from region to region. Birth cohort studies are ideal for investigating different environmental risks. METHODS: The principal investigators of three birth cohorts in Asia including the Taiwan Birth Panel Study (TBPS), the Mothers and Children's Environmental Health Study (MOCEH), and the Hokkaido Study on Environment and Children' Health (Hokkaido Study) coestablished the Birth Cohort Consortium of Asia (BiCCA) in 2011...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028571/identifying-ovarian-tissue-in-the-bitch-using-anti-m%C3%A3-llerian-hormone-amh-or-luteinizing-hormone-lh
#13
Helene Alm, Bodil S Holst
Reliable methods for determining whether or not a bitch has ovarian tissue present are needed for cases with unknown neutering status. Vaginal cytology consistent with heat is indicative of functional ovarian tissue. Other methods are required when the bitch is not presented in suspected heat. Progesterone can be analyzed during 2 months after suspected heat. During other stages, assays for the analyses of anti-Müllerian hormone (AMH) and luteinizing hormone (LH) have been used. The AMH assay is expected to give detectable concentrations (positive) in bitches with ovarian tissue, and the LH assay should give negative results in intact bitches, except during the pre-ovulatory LH peak...
September 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/29026899/few-layered-metallic-1t-mos2-tio2-with-exposed-001-facets-two-dimensional-nanocomposites-for-enhanced-photocatalytic-activities
#14
HyukSu Han, Kang Min Kim, Chan-Woo Lee, Caroline S Lee, Rajendra C Pawar, Jacob L Jones, Yu-Rim Hong, Jeong Ho Ryu, Taeseup Song, Suk Hyun Kang, Heechae Choi, Sungwook Mhin
Titanium dioxide (TiO2) with exposed (001) facets (TiO2(001)) has attractive photocatalytic properties. However, the high recombination rate of the photo-excited charge carriers on this surface often limits its application. Here, we report that a few-layered 1T-MoS2 coating on TiO2(001) nanosheets (abbreviated as MST) can be a promising candidate that overcomes some of the challenges of TiO2(001). Computational and experimental results demonstrate that MST as a photocatalyst exhibits a significantly low-charge recombination rate as well as excellent long-term durability...
October 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29024829/distal-renal-tubular-acidosis-in-a-libyan-patient-evidence-for-digenic-inheritance
#15
Majdi Nagara, Gregori Papagregoriou, Rim Ben Abdallah, Zied Landoulsi, Yosra Bouyacoub, Sahar Elouej, Rym Kefi, Tommaso Pippucci, Voskarides Konstantinos, Anu Bashamboo, Kenneth McElreavey, Mongia Hachicha, Giovanni Romeo, Marco Seri, Constantinos Deltas, Sonia Abdelhak
AIM OF THE STUDY: Recent advances in understanding the underlying molecular mechanism for distal renal tubular acidosis (dRTA), led to an increased attention towards the primary and the familial forms of the disease. Mutations in ATP6V1B1 and ATP6V0A4 are usually responsible for the recessive form of the disease. Mutations in gene AE1 encoding the Cl-/HCO3- exchanger, usually present as dominant dRTA, but a recessive pattern has been recently described. Our objective is to identify the mutational spectrum responsible of dRTA in a consanguineous Libyan family...
October 9, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29024776/update-on-tumor-infiltrating-lymphocytes-tils-in-breast-cancer-including-recommendations-to-assess-tils-in-residual-disease-after-neoadjuvant-therapy-and-in-carcinoma-in-situ-a-report-of-the-international-immuno-oncology-biomarker-working-group-on-breast-cancer
#16
REVIEW
Maria Vittoria Dieci, Nina Radosevic-Robin, Susan Fineberg, Gert van den Eynden, Nils Ternes, Frederique Penault-Llorca, Giancarlo Pruneri, Timothy M D'Alfonso, Sandra Demaria, Carlos Castaneda, Joselyn Sanchez, Sunil Badve, Stefan Michiels, Veerle Bossuyt, Federico Rojo, Baljit Singh, Torsten Nielsen, Giuseppe Viale, Seong-Rim Kim, Stephen Hewitt, Stephan Wienert, Sybille Loibl, David Rimm, Fraser Symmans, Carsten Denkert, Sylvia Adams, Sherene Loi, Roberto Salgado
Morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer is gaining momentum as evidence strengthens the clinical relevance of this immunological biomarker. TILs in the post-neoadjuvant residual disease setting are acquiring increasing importance as a stratifying marker in clinical trials, considering the raising interest on immunotherapeutic strategies after neoadjuvant chemotherapy. TILs in ductal carcinoma in situ, with or without invasive carcinoma, represent an emerging area of clinical breast cancer research...
October 9, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29023591/a-combination-of-selected-mapping-and-clipping-to-increase-energy-efficiency-of-ofdm-systems
#17
Byung Moo Lee, You Seung Rim, Wonjong Noh
We propose an energy efficient combination design for OFDM systems based on selected mapping (SLM) and clipping peak-to-average power ratio (PAPR) reduction techniques, and show the related energy efficiency (EE) performance analysis. The combination of two different PAPR reduction techniques can provide a significant benefit in increasing EE, because it can take advantages of both techniques. For the combination, we choose the clipping and SLM techniques, since the former technique is quite simple and effective, and the latter technique does not cause any signal distortion...
2017: PloS One
https://www.readbyqxmd.com/read/29020487/clinical-characteristics-and-prognostic-factors-in-ankylosing-spondylitis-associated-uveitis
#18
Ji Hwan Lee, Moonjung Choi, Tyler Hyung Taek Rim, Sung Chul Lee, Christopher Seungkyu Lee
PURPOSE: To identify the clinical features and prognostic factors of uveitis associated with ankylosing spondylitis (AS). METHODS: This retrospective, interventional case series study reviewed the medical records of 91 AS patients with uveitis. RESULTS: The characteristics of AS-associated uveitis included male preponderance (70%), average onset in the fourth decade, unilateral manifestation (87.9%), and vitreous involvement or retinal vascular leakage (36...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29020018/probabilistic-numerical-assessment-of-pyroclastic-current-hazard-at-campi-flegrei-and-naples-city-multi-vei-scenarios-as-a-tool-for-full-scale-risk-management
#19
Giuseppe Mastrolorenzo, Danilo M Palladino, Lucia Pappalardo, Sergio Rossano
The Campi Flegrei volcanic field (Italy) poses very high risk to the highly urbanized Neapolitan area. Eruptive history was dominated by explosive activity producing pyroclastic currents (hereon PCs; acronym for Pyroclastic Currents) ranging in scale from localized base surges to regional flows. Here we apply probabilistic numerical simulation approaches to produce PC hazard maps, based on a comprehensive spectrum of flow properties and vent locations. These maps are incorporated in a Geographic Information System (GIS) and provide all probable Volcanic Explosivity Index (VEI) scenarios from different source vents in the caldera, relevant for risk management planning...
2017: PloS One
https://www.readbyqxmd.com/read/29018212/enhanced-therapeutic-treatment-of-colorectal-cancer-using-surface-modified-nanoporous-acupuncture-needles
#20
Bo Ram Lee, Hye-Rim Kim, Eun-Sook Choi, Jung-Hoon Cho, Nam-Jun Kim, Jung-Hee Kim, Kyeong-Min Lee, Abdul Razzaq, Hansaem Choi, Yunju Hwang, Craig A Grimes, Bong-Hyo Lee, Eunjoo Kim, Su-Il In
Acupuncture originated within the auspices of Oriental medicine, and today is used as an alternative method for treating various diseases and symptoms. The physiological mechanisms of acupuncture appear to involve the release of endogenous opiates and neurotransmitters, with the signals mediating through electrical stimulation of the central nervous system (CNS). Earlier we reported a nanoporous stainless steel acupuncture needle with enhanced therapeutic properties, evaluated by electrophysiological and behavioral responses in Sprague-Dawley (SD) rats...
October 10, 2017: Scientific Reports
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