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Aggressive angiomyxoma

Stella Clare Seppings, Hashim Samir, Islam Abdelrahman
A 46-year-old woman presented with a 2-week history of a painless golf ball sized lump in her vagina. Despite transvaginal ultrasound scan, biopsy and MRI, it was only after surgery had been performed that it became clear what the nature of the mass actually was.Immunohistochemistry revealed the lump to be an aggressive angiomyxoma. Follow-up MRI showed residual (or recurrence of) angiomyxoma which was successfully treated with monthly injections of Prostap (leuprorelin acetate), a gonadotropin-releasing hormone agonist...
February 13, 2017: BMJ Case Reports
Mohamed Atef Mohamed Ahmed, Mohamed Ahmed Uehelie, Abdihamid Mohamed Ali Rage, Ahmed Mohey, Yasser A Noureldin
Aggressive angiomyxoma (AA) is a rare, benign, mesenchymal tumor of the pelvis and perineum. It usually occurs in females at reproductive age. However, rare cases have been reported in male children. We present the first case of AA in the penis of a 9-month-old Somalian boy. The infant presented with large, nodular penile mass. The diagnosis was confirmed following complete surgical removal and histopathologic examination. Over a 6-month follow-up period, no recurrence was noticed. Therefore, we recommend complete surgical removal of the mass with wide safety margin and long-term follow-up for cases of AA...
February 1, 2017: Urology
Chang-Tsu Yuan, Wen-Chih Huang, Cheng-Han Lee, Ming-Chieh Lin, Chen-Hui Lee, Yu-Chien Kao, Hsuan-Ying Huang, Kuan-Ting Kuo, Jen-Chieh Lee
BACKGROUND: MED12 exon 2 mutations have been identified in most uterine leiomyomas and mammary fibroepithelial tumors. MED12 has not been genotyped in most other gynecological mesenchymal tumors. DESIGN: 68 uncommon gynecological mesenchymal tumors were genotyped for MED12 exon 2, including 27 müllerian adenosarcomas (including 3 tentatively diagnosed as "variant adenosarcomas"), 6 cellular angiofibromas, 6 aggressive angiomyxomas, 5 angiomyofibroblastomas, 5 superficial myofibroblastomas, 5 atypical polypoid adenomyomas, and 14 endometrial stromal sarcomas...
December 21, 2016: Histopathology
Masataka Kawamura, Fumi Matsumoto, Futoshi Matsui, Koji Yazawa, Kenji Shimada
Aggressive angiomyxoma (AAM) is a rare soft tissue tumor of mesenchymal origin that chiefly involves the vulvar and perineal region. In 90% of cases, AAM presents in women of reproductive age with a peak incidence in the fourth decade of life. To date, AAM of the vulva in young children and infancy has never been reported. We present a case of AAM of the vulva that was initially interpreted as clitoromegaly in a 3-year-old girl.
October 28, 2016: Urology
Theofano Orfanelli, Chi-Son Kim, Sally F Vitez, James Van Gurp, Neeti Misra
Aggressive angiomyxoma is a rare, locally invasive tumor that generally affects the perineum and pelvis of reproductive age females. Aggressive angiomyxoma is often misdiagnosed, resulting in the delay of the treatment. Case reports show increased growth of the tumor during pregnancy, thus suggesting a hormonal dependency. We report this rare condition in a 29-year-old primigravid female with a growing mass on the right labium majus at 20 weeks' gestation. The patient also developed a smaller mass on the left labium majus at 37 weeks' gestation...
2016: Case Reports in Obstetrics and Gynecology
Rashid Saif Al-Umairi, Atheel Kamona, Fadhila Mohammed Al-Busaidi
Aggressive angiomyxoma (AA) is a rare mesenchymal tumor that usually occurs in the pelvis and perineum of young females. AA can simulate Bartholin's gland cyst, abscess, lipoma, simple labial cyst, or other pelvic soft tissue tumors. Cross-sectional imaging, particularly magnetic resonance imaging (MRI), plays an essential role in the diagnosis and management of AA. We report a case of AA in a 38-year-old woman with typical MRI features. We also present the findings of a literature review on the radiological features of this disease...
November 2016: Oman Medical Journal
John C Benson, Scott Gilles, Tina Sanghvi, James Boyum, Eric Niendorf
A 47-year-old female presented to clinic with a 5-year history of a left buttock mass. The patient's hemoglobin was low (9.7 g/dL); laboratory analysis was otherwise unremarkable. Ultrasound of the left gluteal region demonstrated a heterogeneous vascular solid lesion. Magnetic resonance and computed tomography imaging showed an enhancing mass extending from the left ischioanal fossa through the levator ani muscle into the pelvis. Biopsy revealed bland-appearing spindle-shaped cells positive for estrogen and progesterone receptors, consistent with an aggressive angiomyxoma...
December 2016: Radiology case reports
Rinchen Zangmo, Sunesh Kumar, Neeta Singh, Jyoti Meena
No abstract text is available yet for this article.
October 2016: Journal of Obstetrics and Gynaecology of India
Bishnu Prasad Das, Dipankar Baruah, Kaberee Bhuyan Medhi, Bharat Talukder
Aggressive angiomyxoma is a rare, locally invasive mesenchymal tumor predominantly presenting in women of reproductive age and also having a moderate-to-high risk for local relapse. Hence, it needs to be differentiated from other mesenchymal tumors occurring in this region. We present here a case of a 40-year-old female presenting with a large, fleshy, pedunculated mass on the right labia majora.
July 2016: Journal of Mid-life Health
Yin Sun, Lan Zhu, Xiaoyan Chang, Jie Chen, Jinghe Lang
The study was to evaluate the clinicopathological features of aggressive angiomyxoma (AAM) of the female pelvis and perineum and its treatments. This was a retrospective study of female patients with AAM admitted to our hospital. Clinical and pathological data were analyzed, as well as the postsurgical follow-up. Median age at initial presentation was 41 years. Thirteen patients had lesions involving adjacent organs. Eighteen patients underwent complete tumor resection, while one patient underwent partial tumor resection...
January 2017: Pathology Oncology Research: POR
Carrie Chong
No abstract text is available yet for this article.
September 22, 2016: Nurse Practitioner
Henry G Smith, Khin Thway, Christina Messiou, Desmond P Barton, Joseph M Thomas, Andrew J Hayes, Dirk C Strauss, Myles J F Smith
AIM: Aggressive angiomyxomas (AA) are rare tumors, most commonly presenting in the pelvis of women of childbearing age. This study presents the results of selective marginal resection of this disease in patients managed at a single institution. METHODS: Patients diagnosed with AA from July 2001 to July 2015 were identified from a prospectively maintained histopathology database. RESULTS: Seventeen patients were diagnosed with AA in the study period...
December 2016: Journal of Surgical Oncology
Maryse Larouche, Cameron J Hague, Hamid Masoudi, Roxana Geoffrion
No abstract text is available yet for this article.
December 2016: International Urogynecology Journal
Walid Faraj, Mohamad Houjeij, Ali Haydar, Hussein Nassar, Ghina Nounou, Mohamad Khalife
INTRODUCTION: Aggressive angiomyxoma is a rare mesenchymal tumor occurring predominantly in the pelvi-perineal region. It is more common in females during their reproductive age. Our focus is on the surgical approach for a recurrent angiomyxoma. CASE PRESENTATION: We present a case of a 36-year-old female patient with a recurrent lower back and perineal bulges. One year ago, she had the same presentation and underwent resection of that mass in a peripheral hospital without available information...
2016: International Journal of Surgery Case Reports
Alper Sozutek, Oktay Irkorucu, Enver Reyhan, Kemal Yener, Ali Ayberk Besen, Kivilcim Eren Erdogan, Gulfiliz Gonlusen, Figen Doran
Aggressive angiomyxoma (AA) is an uncommon mesenchymal tumor that is mostly derived from the female pelvic and perineal regions. AA is a locally infiltrative slow growing tumor with a marked tendency to local recurrence. Painless swelling located around the genitofemoral region is the common symptom; thus, it is often misdiagnosed as a gynecological malignancy or a groin hernia. A 35-year-old female patient who previously underwent surgery for left femoral hernia operation resulting in surgical failure was reoperated for a giant AA located in the pelvis...
2016: Case Reports in Surgery
J Sampaio, I Sarmento-Gonçalves, D Ramada, T Amaro, P Tiago-Silva
Introduction. Aggressive angiomyxoma is a rare mesenchymal neoplasm. Although benign in the majority of the cases, these neoplasms usually present a locally infiltrative nature and high rates of recurrence. Due to its rarity, misdiagnosis is a common problem. Case Presentation. We present one case of aggressive angiomyxoma in a 25-year-old pregnant woman. The patient presented with a large vaginal mass that was interpreted as a vaginal cyst. We performed surgical resection of the neoplasm and the correct diagnosis was only achieved after histological examination...
2016: Case Reports in Obstetrics and Gynecology
Yin-Feng Wang, Hong-Lang Qian, Hang-Mei Jin
Aggressive angiomyxoma (AAM) and angiomyofibroblastoma (AMFB) are two rare types of mesenchymal tumors with overlapping clinicopathological features. In certain cases, the differential diagnosis between the two tumors is difficult even for experienced pathologists. The present study reported the case of a well-circumscribed soft tissue mass on the anterior wall of the vagina in a 25-year-old woman. The mass was initially removed without disturbance to the adjacent tissues. The histopathological features included spindle cells in inconspicuous myxoid stroma and a well-demarcated mass without evidence of invasion, which prompted the initial diagnosis of AMFB...
May 2016: Experimental and Therapeutic Medicine
Sun-Wha Im, Seung Su Han
No abstract text is available yet for this article.
August 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Chisa Narayama, Masae Ikeda, Miwa Yasaka, Yu-suke Sagara, Yasuhira Kan-no, Io Hayashi, Atuya Narita, Satoshi Asai, Toshiki Tajima, Masako Shida, Takeshi Hirasawa, Mikio Mikami
We report a case of vulvar aggressive angiomyxoma (AA) which is a rare, slow growing and benign tumor of mesenchymal origin, but has a high risk of local recurrence. A 49-year-old Japanese female was referred to us with a large mass of the left vulva, measuring 15×9.5×9 centimeters. She underwent surgical excision of the tumor with no evidence of recurrence on a 5-year follow up. In this case, histopathological examination and immunohistochemical staining after excision revealed a diagnosis of vulvar AA with estrogen and progesterone receptors positive...
March 20, 2016: Tokai Journal of Experimental and Clinical Medicine
Vicente Artigas Raventós, Diego Rivero Cruces, José González López, Manuel Rodríguez Blanco, Isidre Boguña
No abstract text is available yet for this article.
June 2016: Cirugía Española
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