keyword
MENU ▼
Read by QxMD icon Read
search

ROS

keyword
https://www.readbyqxmd.com/read/28743163/alk-and-ros1-testing-on-lung-cancer-cytologic-samples-perspectives
#1
REVIEW
Pasquale Pisapia, Maria D Lozano, Elena Vigliar, Claudio Bellevicine, Francesco Pepe, Umberto Malapelle, Giancarlo Troncone
Cytologic sampling is the mainstay of diagnosing advanced lung cancer. Moreover, to select patients for personalized first-line or second-line treatment, epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) rearrangements are tested on cytologic preparations. Commercially available fluorescence in situ hybridization (FISH) and immunocytochemistry (ICC) assays have primarily been used for the identification of cells harboring ALK or ROS1 gene fusions on histologic rather than cytologic preparations...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28743058/oral-nanotherapeutics-redox-nanoparticles-attenuate-ultraviolet-b-radiation-induced-skin-inflammatory-disorders-in-kud-hr-hairless-mice
#2
Chitho P Feliciano, Yukio Nagasaki
The active participation of an anti-inflammatory drug in the biological pathways of inflammation is crucial for the achievement of beneficial and therapeutic effects. This study demonstrated the development of redox nanoparticles that can circulate in the blood at significantly high levels, thus increasing their efficacy as an oral treatment against the deleterious effects of reactive oxygen species (ROS) in an in vivo inflammatory skin model. To confirm the blood bioavailability of the nanoparticles, mice were injected with the nanoparticles solution (RNP(N)) via oral gavage...
July 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28742872/the-wheat-wrky-transcription-factors-tawrky49-and-tawrky62-confer-differential-high-temperature-seedling-plant-resistance-to-puccinia-striiformis-f-sp-tritici
#3
Junjuan Wang, Fei Tao, Wei Tian, Zhongfeng Guo, Xianming Chen, Xiangming Xu, Hongsheng Shang, Xiaoping Hu
WRKY transcription factors (TFs) play crucial roles in plant resistance responses to pathogens. Wheat stripe rust, caused by the fungal pathogen Puccinia striiformis f. sp. tritici (Pst), is a destructive disease of wheat (Triticum aestivum) worldwide. In this study, the two WRKY genes TaWRKY49 and TaWRKY62 were originally identified in association with high-temperature seedling-plant resistance to Pst (HTSP) resistance in wheat cultivar Xiaoyan 6 by RNA-seq. Interestingly, the expression levels of TaWRKY49 and TaWRKY62 were down- and up-regulated, respectively, during HTSP resistance in response to Pst...
2017: PloS One
https://www.readbyqxmd.com/read/28742227/melatonin-prevents-mitochondrial-dysfunctions-and-death-in-differentiated-skeletal-muscle-cells
#4
Sara Salucci, Michela Battistelli, Valentina Baldassarri, Debora Burini, Elisabetta Falcieri, Sabrina Burattini
Oxidative stress increase induces cellular damage and apoptosis activation, a mechanism believed to represent a final common pathway correlated to sarcopenia and many skeletal muscle disorders. The goal of this study is to evaluate if melatonin, a ROS scavenger molecule, is able to counteract or modulate myotube death. Here, differentiated C2C12 skeletal muscle cells have been treated with melatonin before chemicals known to induce apoptotic death and oxidative stress, and its effect has been investigated by means of morpho-functional analyses...
July 25, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28741939/the-influence-of-electric-fields-on-biofouling-of-carbonaceous-electrodes
#5
Soumya Pandit, Sneha Shanbhag, Meagan S Mauter, Yoram Oren, Moshe Herzberg
Biofouling commonly occurs on carbonaceous capacitive deionization electrodes in the process of treating natural waters. Although previous work reported the effect of electric fields on bacterial mortality for variety of medical and engineered applications, the effect of electrode surface properties and the magnitude and polarity of applied electric fields on biofilm development has not been comprehensively investigated. This paper studies the formation of Pseudomonas aeruginosa biofilm on Papyex graphite (PA) and carbon aerogel (CA) in presence and absence of an electric field...
July 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28741846/confinement-of-reactive-oxygen-species-in-artificial-enzyme-based-hollow-structure-for-eliminating-photocatalytic-adverse-effect-of-uv-filters
#6
Enguo Ju, Kai Dong, Zhenzhen Wang, Yan Zhang, Fangfang Cao, Zhaowei Chen, Fang Pu, Jinsong Ren, Xiaogang Qu
Skin cancers caused by UV irradiation have been a major public health problem. One simple and effective way to avoid the above detrimental effects is the use of UV-protective sunscreens. However, there has been considerable concern with the issue of production of reactive oxygen species by the photo-degradation of commercial UV filters. Herein, we reported for the first time that the integration of ZnO nanoparticles and CeOx nanoparticles into hollow microspheres (ZnO/CeOx HMS) could provide broad UV spectrum protection and scavenge generated ROS under UV irradiation...
July 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28741693/antioxidants-protect-proteins-anchorage-to-the-bilayer-by-improving-plasma-membrane-integrity-of-ram-spermatozoa-during-liquid-preservation-in-a-soya-lecithin-based-diluent
#7
R K Paul, D Kumar, Smk Naqvi
Antioxidants are known to prevent the reactive oxygen species (ROS)-mediated peroxidative damage to the membrane lipids during hypothermic storage of mammalian spermatozoa. We hypothesized here that ROS also affect the lipid-protein interactions, thereby diminishing the membrane's integrity and proteins' anchorage to the bilayer. Antioxidants prevent these damages by scavenging the ROS. Ejaculates from Patanwadi rams were pooled after subjective evaluation and centrifuged using Percoll(®) . Sperm pellet was resuspended in soya lecithin-Tris-fructose diluent (400 × 10(6)  cells/ml) containing either antioxidants (100 IU/ml catalase + 10 mM reduced glutathione) or no antioxidant...
July 25, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28741634/mitochondria-targeting-near-infrared-light-triggered-thermosensitive-liposomes-for-localized-photothermal-and-photodynamic-ablation-of-tumors-combined-with-chemotherapy
#8
Caixia Yue, Yuming Yang, Jie Song, Gabriel Alfranca, Chunlei Zhang, Qian Zhang, Ting Yin, Fei Pan, Jesús M de la Fuente, Daxiang Cui
Lonidamine, an anticancer drug that acts on mitochondria, has poor water solubility. Mitochondria are the primary source of cellular reactive oxygen species (ROS), which are necessary for photodynamic therapy. Hence, a mitochondria-targeting drug delivery system loaded with Lonidamine and a ROS-produced photosensitizer could improve the bioavailability of Lonidamine and maximize photodynamic therapeutic efficiency. Here we report, for the first time, new IR-780 and Lonidamine encapsulated mitochondria-targeting thermosensitive liposomes (IL-TTSL)...
July 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28741598/plasmonic-enhancement-of-cyanine-dyes-for-near-infrared-light-triggered-photodynamic-photothermal-therapy-and-fluorescent-imaging
#9
Mindan Lu, Ning Kang, Chuan Chen, Liuqing Yang, Yang Li, Minghui Hong, Xiangang Luo, Lei Ren, Xiumin Wang
Near infrared (NIR) triggered cyanine dyes have attracted considerable attentions in multi-modal tumor theranostics. However, near infrared (NIR) cyanine dyes used in tumor treatment often suffer from low fluorescence intensity and weak singlet oxygen generation efficiency, resulting in inadequate diagnostic and therapy efficacies for tumors. It is still a great challenge to improve both the photodynamic therapy (PDT) and fluorescent imaging (FLI) efficacy of cyanine dyes in tumor applications. Herein, a novel multifunctional nanoagent of AuNRs@SiO2-IR795 was developed to realize the integrated photothermal/photodynamic therapy (PTT/PDT) and FLI at a very low dosage of IR795 (0...
July 25, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28740747/in-vitro-assessment-of-anti-proliferative-effect-induced-by-%C3%AE-mangostin-from-cratoxylum-arborescens-on-hela-cells
#10
Aisha I El Habbash, Najihah Mohd Hashim, Mohamed Yousif Ibrahim, Maizatulakmal Yahayu, Fatima Abd Elmutaal Omer, Mashitoh Abd Rahman, Noraziah Nordin, Gwendoline Ee Cheng Lian
Natural medicinal products possess diverse chemical structures and have been an essential source for drug discovery. Therefore, in this study, α-mangostin (AM) is a plant-derived compound was investigated for the apoptotic effect on human cervical cancer cells (HeLa). The cytotoxic effects of AM on the viability of HeLa and human normal ovarian cell line (SV40) were evaluated by using MTT assay. Results showed that AM inhibited HeLa cells viability at concentration- and time-dependent manner with IC50 value of 24...
2017: PeerJ
https://www.readbyqxmd.com/read/28740404/reactive-oxygen-species-mediate-soft-corals-derived-sinuleptolide-induced-antiproliferation-and-dna-damage-in-oral-cancer-cells
#11
Yung-Ting Chang, Chiung-Yao Huang, Jen-Yang Tang, Chih-Chuang Liaw, Ruei-Nian Li, Jing-Ru Liu, Jyh-Horng Sheu, Hsueh-Wei Chang
We previously reported that the soft coral-derived bioactive substance, sinuleptolide, can inhibit the proliferation of oral cancer cells in association with oxidative stress. The functional role of oxidative stress in the cell-killing effect of sinuleptolide on oral cancer cells was not investigated as yet. To address this question, we introduced the reactive oxygen species (ROS) scavenger (N-acetylcysteine [NAC]) in a pretreatment to evaluate the sinuleptolide-induced changes to cell viability, morphology, intracellular ROS, mitochondrial superoxide, apoptosis, and DNA damage of oral cancer cells (Ca9-22)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28739829/inherent-oxidative-stress-in-lewis-rat-is-associated-with-resistance-to-toxoplasmosis
#12
William H Witola, Chi Yong Kim, Xuejin Zhang
The course of Toxoplasma gondii infection in rats closely resembles that in humans. However, compared to the Brown Norway (BN) rat, the Lewis (LEW) rat is extremely resistant to T. gondii infection. Thus, we performed RNA sequencing analysis of the LEW versus BN rat, with or without T. gondii infection, in order to unravel molecular factors directing robust and rapid early T. gondii-killing mechanisms in the LEW rat. We found that, compared to the uninfected BN rat, the uninfected LEW rat has inherently higher transcript levels of cytochrome enzymes [Cyp2d3, Cyp2d5 and Cybrd1 that catalyze generation of reactive oxygen species (ROS)], with concomitant higher levels of ROS...
July 24, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28739801/sustained-o-glcnacylation-reprograms-mitochondrial-function-to-regulate-energy-metabolism
#13
Ee Phie Tan, Steven R McGreal, Stefan Graw, Robert Tessman, Scott J Koppel, Pramod Dhakal, Zhen Zhang, Miranda Machacek, Natasha E Zachara, Devin C Koestler, Kenneth R Peterson, John P Thyfault, Russell H Swerdlow, Partha Krishnamurthy, Luciano DiTacchio, Udayan Apte, Chad Slawson
Dysfunctional mitochondria and generation of reactive oxygen species (ROS) promote chronic diseases, which have spurred interest in the molecular mechanisms underlying these conditions. Previously, we have demonstrated that disruption of post-translational modification of proteins with β-linked N-acetylglucosamine (O-GlcNAcylation) via overexpression of the O-GlcNAc regulating enzymes O-GlcNAc transferase (OGT) or O-GlcNAcase (OGA) impairs mitochondrial function. Here, we report that sustained alterations in O-GlcNAcylation either by pharmacological or genetic manipulation also alters metabolic function...
July 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28739695/synergistic-effects-of-arsenite-on-radiosensitization-of-glioblastoma-cells
#14
Yasuharu Ninomiya, Dong Yu, Emiko Sekine-Suzuki, Tetsuo Nakajima
BACKGROUND/AIM: Glioblastoma is a frequent type of brain tumor and is radioresistant. Arsenite, which crosses the blood-brain barrier, shows synergistic effects with radiation in vitro and in vivo. The mechanism remains unclear. MATERIALS AND METHODS: As synergistic radiosensitization has been reported in p53-deficient cancer cells, radiosensitization was evaluated using the glioblastoma cell line, U87MG-E6, which harbors inactivated p53, in comparison with the cell line, HCT116 p53 (-/-)...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739532/denervated-muscle-fibers-induce-mitochondrial-peroxide-generation-in-neighboring-innervated-fibers-role-in-muscle-aging
#15
Natalie Pollock, Caroline Staunton, Aphrodite Vasilaki, Anne McArdle, Malcolm J Jackson
Disruption of neuromuscular junctions and denervation of some muscle fibres occurs in ageing skeletal muscle and contribute to loss of muscle mass and function. Aging is associated with mitochondrial dysfunction and loss of redox homeostasis potentially occurs through increased mitochondrial generation of reactive oxygen species (ROS). No specific link between increased mitochondrial ROS generation and denervation has been defined in muscle ageing. To address this, we have examined the effect of experimental denervation of all fibers, or only a proportion of the fibers, in the mouse tibialis anterior (TA) muscle on muscle mitochondrial peroxide generation...
July 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28739512/modulation-of-mitochondrial-dysfunction-related-oxidative-stress-in-fibroblasts-of-patients-with-leigh-syndrome-by-inhibition-of-prooxidative-p66shc-pathway
#16
Aleksandra Wojtala, Agnieszka Karkucinska-Wieckowska, Vilma A Sardao, Joanna Szczepanowska, Pawel Kowalski, Maciej Pronicki, Jerzy Duszynski, Mariusz R Wieckowski
The mitochondrial respiratory chain, and in particular, complex I, is a major source of reactive oxygen species (ROS) in cells. Elevated levels of ROS are associated with an imbalance between the rate of ROS formation and the capacity of the antioxidant defense system. Increased ROS production may lead to oxidation of DNA, lipids and proteins and thus can affect fundamental cellular processes. The aim of this study was to investigate the magnitude of intracellular oxidative stress in fibroblasts of patients with Leigh syndrome with defined mutations in complex I...
July 21, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28739487/the-ros-mediated-activation-of-il-6-stat3-signaling-pathway-is-involved-in-the-27-hydroxycholesterol-induced-cellular-senescence-in-nerve-cells
#17
Jiao Liu, Yun Liu, Juan Chen, Chunyan Hu, Mengying Teng, Kailin Jiao, Zhaoxia Shen, Dongmei Zhu, Jia Yue, Zhong Li, Yuan Li
The oxysterol 27-hydroxycholesterol (27HC) is a selective estrogen receptor modulator (SERMs), which like endogenous estrogen 17β-estradiol (E2) induces the proliferation of ER-positive breast cancer cells in vitro. Interestingly, the observation that 27HC induces adverse effects in neural system, distinguishing it from E2. It has been suggested that high levels of circulating cholesterol increase the entry of 27HC into the brain, which may induce learning and memory impairment. Based on this evidence, 27HC may be associated with neurodegenerative processes and interrupted cholesterol homeostasis in the brain...
July 21, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28739368/andrographolide-induces-oxidative-stress-dependent-cell-death-in-unicellular-protozoan-parasite-trypanosoma-brucei
#18
Malabika Banerjee, Debaprasad Parai, Pranab Dhar, Manab Roy, Rajib Barik, Subrata Chattopadhyay, Samir Kumar Mukherjee
African sleeping sickness is a parasitic disease in humans and livestock caused by Trypanosoma brucei throughout sub-Saharan Africa. Absence of appropriate vaccines and prevalence of drug resistance proclaim that a new way of therapeutic interventions is essential against African trypanosomiasis. In the present study, we have looked into the effect of andrographolide (andro), a diterpenoid lactone from Andrographis paiculata on Trypanosoma brucei PRA 380. Although andro has been recognized as a promosing anti-cancer drug, its usefulness against Trypanosoma spp remained unexplored...
July 21, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28739324/reaction-based-small-molecule-fluorescent-probes-for-dynamic-detection-of-ros-and-transient-redox-changes-in-living-cells-and-small-animals
#19
REVIEW
Rui Lü
Dynamic detection of transient redox changes in living cells and animals has broad implications for human health and disease diagnosis, because intracellular redox homeostasis regulated by reactive oxygen species (ROS) plays important role in cell functions, normal physiological functions and some serious human diseases (e.g., cancer, Alzheimer's disease, diabetes, etc.) usually have close relationship with the intracellular redox status. Small-molecule ROS-responsive fluorescent probes can act as powerful tools for dynamic detection of ROS and redox changes in living cells and animals through fluorescence imaging techniques; and great advances have been achieved recently in the design and synthesis of small-molecule ROS-responsive fluorescent probes...
July 21, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28738977/glutathione-peroxidase-3-gene-polymorphisms-and-the-risk-of-sudden-sensorineural-hearing-loss
#20
Chen-Yu Chien, Tzu-Yen Huang, Shu-Yu Tai, Ning-Chia Chang, Hsun-Mo Wang, Ling-Feng Wang, Kuen-Yao Ho
The glutathione peroxidase 3 gene (GPX3) is reported to be a risk factor for arterial ischaemic stroke and cerebral venous thrombosis. GPX3 may be one of the aetiologies of sudden sensorineural hearing loss (SSNHL), which might be attributed to the genetic effect of GPX3 by influence reactive oxygen species (ROS). Unbalanced ROS have been associated with susceptibility to SSNHL. Therefore, we conducted a case-control study with 416 SSNHL cases and 255 controls. Five single nucleotide polymorphisms (SNPs) were selected...
July 2017: Kaohsiung Journal of Medical Sciences
keyword
keyword
13847
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"