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https://www.readbyqxmd.com/read/28527426/malvidin-and-cyanidin-derivatives-from-a%C3%A3-ai-fruit-euterpe-oleracea-mart-counteract-uv-a-induced-oxidative-stress-in-immortalized-fibroblasts
#1
Ganna Petruk, Anna Illiano, Rita Del Giudice, Assunta Raiola, Angela Amoresano, Maria Manuela Rigano, Renata Piccoli, Daria Maria Monti
UV-A radiations are known to induce cellular oxidative stress, leading to premature skin aging. Consumption of açai fruit (Euterpe oleracea Martius) is known to have many health benefits due to its high level of antioxidants. Herein, we analyzed the ability of phenolic compounds extracted from this fruit to attenuate UV-A-induced oxidative stress in immortalized fibroblast. A methanol/water açai extract was fractionated by HPLC and each fraction tested for anti-oxidant stress activity. Immortalized fibroblasts were pre-incubated with açai fractions and then exposed to UV-A radiations...
May 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28527361/preparation-and-antifouling-properties-of-2-meth-acryloyloxy-ethyl-cholinephosphate-based-polymers-modified-surface-with-different-molecular-architectures-by-atrp
#2
Yuchen Jiang, Yuling Su, Lili Zhao, Fancui Meng, Quanxin Wang, Chunmei Ding, Jianbin Luo, Jianshu Li
Choline phosphate (CP) containing polymers modified surfaces have been shown good resist to the adhesion of proteins while prompt the attaching of mammalian cells due to the dipole pairing between the CP groups of the polymer and the phosphorylcholine (PC) groups on the cell membrane. However, the antifouling activities of CP modified surface against microbes have not been investigated at present. In addition, CP containing polymers modified surface with different molecular architectures has not been prepared and studied...
May 11, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28527359/nanocubes-of-indium-oxide-induce-cytotoxicity-and-apoptosis-through-oxidative-stress-in-human-lung-epithelial-cells
#3
Maqusood Ahamed, Mohd Javed Akhtar, M A Majeed Khan, Hisham A Alhadlaq, Ali Aldalbahi
The demand for semiconductor indium oxide (In2O3) nanocrystals is increasing because of their diverse applications, including in biomedicine. However, there is a scarcity of studies on the biological interaction of indium oxide nanocrystals. Here, we explored the underlying mechanisms of toxicity induced by indium oxide nanocubes in human lung epithelial (A549) cells. Prepared indium oxide nanocubes were crystalline with an average size of 21nm. Biointeraction studies have shown that indium oxide nanocubes induce cell viability reduction and cell membrane damage in a dose- and time-dependent manner...
May 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28527355/antimycotic-activity-of-fengycin-c-biosurfactant-and-its-interaction-with-phosphatidylcholine-model-membranes
#4
Lina María González-Jaramillo, Francisco José Aranda, José Antonio Teruel, Valeska Villegas-Escobar, Antonio Ortiz
Lipopeptide biosurfactants constitute one of the most promising groups of compounds for the treatment and prevention of fungal diseases in plants. Bacillus subtilis strain EA-CB0015 produces iturin A, fengycin C and surfactin and it has been proven useful for the treatment of black Sigatoka disease in banana plants, an important pathology caused by the fungus Mycosphaerella fijiensis (Morelet). We have found that B. subtilis EA-CB0015 cell free supernatants and purified fractions inhibit M. fijiensis cellular growth...
May 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28527348/the-thermal-neutron-facility-hotnes-theoretical-design
#5
R Bedogni, A Pietropaolo, J M Gomez-Ros
HOTNES (HOmogeneous Thermal NEutron Source) is a thermal neutron irradiation facility with extended and very uniform irradiation area. A (241)Am-B radionuclide neutron source with nominal strenght 3.5×10(6) s(-1) is located on bottom of a large cylindrical cavity (30cm diameter, 70cm in height) delimited by polyethylene walls. The upper part of this volume (30cm diameter, 40cm in height) is used to irradiate samples. A polyethylene cylinder, acting as shadowing object, prevents fast neutrons to directly reach the irradiation volume...
May 4, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28527346/inhibitory-effects-of-2-oxo-2h-chromen-4-yl-4-methylbenzenesulfonate-on-allergic-inflammatory-responses-in-rat-basophilic-leukemia-cells
#6
Gaeun Yoo, Kooyeon Lee, Deug-Chan Lee
Mast cells play crucial roles in the initiation of allergic inflammatory responses by releasing various mediators such as histamines, cytokines, and leukotrienes. In addition, signaling cascade pathways, such as the mitogen-activated protein kinase (MAPK) pathway, contribute to the regulation of mast cell degranulation. Accordingly, different research strategies have been pursued to develop anti-inflammatory and anti-allergic drugs by regulating these signaling pathways. The development of new drugs that inhibit mast cell degranulation may help in the treatment of allergies...
May 17, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28527337/improved-stress-tolerance-and-productivity-in-transgenic-rice-plants-constitutively-expressing-the-oryza-sativa-glutathione-synthetase-osgs-under-paddy-field-conditions
#7
Seong-Im Park, Young-Saeng Kim, Jin-Ju Kim, Ji-Eun Mok, Yul-Ho Kim, Hyang-Mi Park, Il-Sup Kim, Ho-Sung Yoon
Reactive oxygen species, which increase under various environmental stresses, have deleterious effects on plants. An important antioxidant, glutathione, is used to detoxify reactive oxygen species in plant cells and is mainly produced by two enzymes: gamma-glutamylcysteine synthetase (γ-ECS) and glutathione synthetase (GS). To evaluate the functional roles of the glutathione synthetase gene (OsGS) in rice, we generated four independent transgenic rice plants (TG1-TG4) that overexpressed OsGS under the control of the constitutively expressed OsCc1 promoter...
May 10, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28527325/dyslipidemia-management-update
#8
REVIEW
Yingzi Chang, Jacques Robidoux
Association of hypercholesterolemia and atherosclerotic cardiovascular disease (ASCVD) is well established. Reducing low-density lipoprotein-cholesterol (LDL-C) and raising high-density lipoprotein-cholesterol (HDL-C) have been the therapeutic targets to reduce the risk of ASCVD. Cholesterol-lowering medications have been used to provide both primary and secondary prevention of ASCVD for many years by reducing the absorption and reabsorption, promoting excretion, or decreasing the synthesis of cholesterol. Within the past five years, several new classes of cholesterol-lowering drugs have been tested and approved for patients with hypercholesterolemia that are not well controlled by conventional therapy (ezetimibe, bile-acid sequestrants, and statins)...
May 17, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28527286/-possible-oral-transmission-of-chagas-disease-among-hydrocarbons-sector-workers-in-casanare-colombia-2014
#9
Liliana Patricia Zuleta-Dueñas, Ángela Johana López-Quiroga, Fernando Torres-Torres, Oneida Castañeda-Porras
INTRODUCTION: Trypanosoma cruzi, the etiological agent for Chagas disease, can be transmitted by oral intake of contaminated food or drinks. During epidemiological week 14 of 2014, two cases of acute Chagas disease were notified among hydrocarbons sector workers in Paz de Ariporo, Casanare. OBJECTIVE: To characterize the affected population, to establish control and prevention measures and to confirm the outbreak. MATERIALS AND METHODS: We conducted an outbreak investigation that included the following components: a) Search for symptomatic people compatible with Chagas disease according to the case definition for their referral to medical services; b) entomological survey (192/197 houses); c) sanitary inspection and microbiological analysis of food samples; and d) study of reservoirs...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527264/-adverse-drug-reactions-in-neonates-hospitalized-in-neonatal-intensive-care-units-in-barranquilla-colombia
#10
Roxana De Las Salas, Daniela Díaz-Agudelo
INTRODUCTION: The appearance of adverse drug reactions in neonates is an important issue due to the lack of drug safety data. OBJECTIVE: To identify the behavior of adverse drug reactions (ADR) in hospitalized neonates at two intensive care units in Barranquilla, Colombia. MATERIALS AND METHODS: We conducted a cross-sectional prospective descriptive study based on patientcentered intensive pharmacosurveillance. We followed up and monitored the appearance of ADRs for six months...
April 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527261/-posterior-reversible-encephalopathy-syndrome-report-of-a-fatal-case-and-analysis-of-predictive-factors-of-a-poor-prognosis
#11
Moisés Ulises Torres, Ligia Victoria Delgado, Natalia Giraldo, Piedad Urueña, Sergio Franco, Olga Helena Hernández
Posterior reversible encephalopathy syndrome is an illness with multiple causes and distinctive clinicalradiological characteristics that should be known by intensivists and emergency room physicians for a timely diagnosis and treatment. A fatal case of posterior reversible encephalopathy syndrome is presented, and the risk factors related to the outcome are identified.A 60-year-old man without a relevant medical history arrived at the emergency room presenting with depressed consciousness, seizures, and high blood pressure...
April 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527240/recurrent-deep-vein-thrombosis-after-the-first-venous-thromboembolism-event-a-single-institution-experience
#12
Mohammad Asim, Hassan Al-Thani, Ayman El-Menyar
BACKGROUND We investigated the frequency, clinical presentation, risk factors, and outcome after the first deep vein thrombosis (DVT) event. MATERIAL AND METHODS A retrospective study was conducted for patients with DVT between 2008 and 2012 with a 1-year follow-up. Patients were divided into 2 groups: single vs. recurrent DVT (RDVT). RESULTS Of the 6420 patients screened for DVT, 662 (10.3%) had DVT. RDVT constituted 22% of cases. A single event was more frequent in left lower limb DVT (p=0.01), while RDVT cases had more bilateral DVT (p=0...
May 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28527228/efficacy-of-neuromuscular-electrical-stimulation-for-preventing-quadriceps-muscle-wasting-in-patients-with-moderate-or-severe-acute-stroke-a-pilot-study
#13
Masafumi Nozoe, Masashi Kanai, Hiroki Kubo, Yuka Takeuchi, Miki Kobayashi, Miho Yamamoto, Asami Furuichi, Makoto Yamazaki, Shinichi Shimada, Kyoshi Mase
BACKGROUND: Stroke-related muscle wasting is one of the factors leading to long-term disability and functional dependency. No study has reported an effective therapeutic intervention for such muscle wasting. OBJECTIVE: The purpose of this study was to investigate the effects of neuromuscular electrical stimulation (NMES) on quadriceps muscle mass preservation in patients with acute moderate or severe stroke by using ultrasonography (US). METHODS: Twenty patients with acute, moderate, or severe stroke (age: 68±11 years) were divided into usual care group (control group) and intervention groups (NMES group), respectively...
May 19, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28527212/apolipoprotein-e4-gender-body-mass-index-inflammation-insulin-resistance-and-air-pollution-interactions-recipe-for-alzheimer-s-disease-development-in-mexico-city-young-females
#14
Lilian Calderón-Garcidueñas, Suzanne M de la Monte
Given the epidemiological trends of increasing Alzheimer's disease (AD) and growing evidence that exposure and lifestyle factors contribute to AD risk and pathogenesis, attention should be paid to variables such as air pollution, in order to reduce rates of cognitive decline and dementia. Exposure to fine particulate matter (PM2.5) and ozone (O3) above the US EPA standards is associated with AD risk. Mexico City children experienced pre- and postnatal high exposures to PM2.5, O3, combustion-derived iron-rich nanoparticles, metals, polycyclic aromatic hydrocarbons, and endotoxins...
May 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28527205/moderate-physical-activity-is-associated-with-cerebral-glucose-metabolism-in-adults-at-risk-for-alzheimer-s-disease
#15
Ryan J Dougherty, Stephanie A Schultz, Taylor K Kirby, Elizabeth A Boots, Jennifer M Oh, Dorothy Edwards, Catherine L Gallagher, Cynthia M Carlsson, Barbara B Bendlin, Sanjay Asthana, Mark A Sager, Bruce P Hermann, Bradley T Christian, Sterling C Johnson, Dane B Cook, Ozioma C Okonkwo
The objective of this study was to investigate the relationship between accelerometer-measured physical activity (PA) and glucose metabolism in asymptomatic late-middle-aged adults. Ninety-three cognitively healthy late-middle-aged adults from the Wisconsin Registry for Alzheimer's Prevention participated in this cross-sectional study. They underwent 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging and wore an accelerometer (ActiGraph GT3X+) to measure free-living PA. Accelerometer data yielded measures of light (LPA), moderate (MPA), and vigorous (VPA) intensity PA...
May 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28527165/twelve-commandments-to-prevent-tsunami-of-cardiometabolic-syndrome-in-india-by-2025
#16
Ramchandra Lele
No abstract text is available yet for this article.
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28527152/socioenvironmental-factors-associated-with-heat-and-cold-related-mortality-in-vadu-hdss-western-india-a-population-based-case-crossover-study
#17
Vijendra Ingole, Sari Kovats, Barbara Schumann, Shakoor Hajat, Joacim Rocklöv, Sanjay Juvekar, Ben Armstrong
Ambient temperatures (heat and cold) are associated with mortality, but limited research is available about groups most vulnerable to these effects in rural populations. We estimated the effects of heat and cold on daily mortality among different sociodemographic groups in the Vadu HDSS area, western India. We studied all deaths in the Vadu HDSS area during 2004-2013. A conditional logistic regression model in a case-crossover design was used. Separate analyses were carried out for summer and winter season...
May 19, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28527144/the-effects-of-experimentally-supplied-lead-nitrate-on-three-common-mediterranean-moss-species
#18
Jennifer Cogolludo, Belén Estébanez, Nagore G Medina
We assess here, through an experimental simulation using lead nitrate, the response to lead deposition of three common Mediterranean bryophyte species in the family Pottiaceae. Five concentrations of lead nitrate (from 0 to 10(-3) M) were sprayed for 4 months on plants belonging to Tortula muralis (reported as toxitolerant), Syntrichia ruralis (medium-tolerant), and Tortula subulata (less tolerant). The three species showed a remarkably high tolerance to lead nitrate, with a low incidence of damage even at concentrations as high as 10(-4) M...
May 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28527100/parents-expectations-of-high-schools-in-firearm-violence-prevention
#19
Erica Payton, Jagdish Khubchandani, Amy Thompson, James H Price
Firearm violence remains a significant problem in the US (with 2787 adolescents killed in 2015). However, the research on school firearm violence prevention practices and policies is scant. Parents are major stakeholders in relation to firearm violence by youths and school safety in general. The purpose of this study was to examine what parents thought schools should be doing to reduce the risk of firearm violence in schools. A valid and reliable questionnaire was mailed to a national random sample of 600 parents who had at least one child enrolled in a public secondary school (response rate = 47%)...
May 19, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28527085/the-use-of-nutraceutics-in-children-s-and-adolescent-s-headache
#20
R Sangermani, A Boncimino
Nutraceutics are the most used non-pharmacological remedies for migraine's prophylaxis in children and adolescents. Doctors interested in use of nutraceuticals for a complete treatment of children's headache should be adequately informed on this treatments' efficacy and safety. Actually there is a lack of official guidelines about use of nutraceuticals in migraine's prevention in children and adolescent and there are few studies with limited efficacy evidences. The most used nutraceuticals for adolescent's and children's headache prophylaxis are: magnesium, coenzyme Q10, riboflavin, butterbur, feverfew and melatonin...
May 2017: Neurological Sciences
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