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https://www.readbyqxmd.com/read/29356440/adherence-and-medication-belief-in-patients-with-pulmonary-arterial-hypertension-or-chronic-thromboembolic-pulmonary-hypertension-a-nationwide-population-based-cohort-survey
#1
Bodil Ivarsson, Roger Hesselstrand, Göran Rådegran, Barbro Kjellström
BACKGROUND: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are rare diseases with a gradual decline in physical health. Adherence to treatment is crucial in these very symptomatic and life threatening diseases. OBJECTIVE: To describe PAH and CTEPH patients experience of their self-reported medication adherence, beliefs about medicines and information about treatment. METHODS: A quantitative, descriptive, national cohort survey that included adult patients from all PAH-centres in Sweden...
January 22, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29356434/5-chloro-2-4-dihydroxypyridine-cdhp-prevents-lung-metastasis-of-basal-like-breast-cancer-cells-by-reducing-nascent-adhesion-formation
#2
Junji Itou, Hiroshi Tsukihara, Mamoru Nukatsuka, Masakazu Toi, Teiji Takechi
A drug for metastasis prevention is necessary. The orally administered anticancer drug S-1 contributes to cancer therapy. In a mouse xenograft model of metastatic breast cancer from our previous study, the administration of S-1 inhibited lung metastasis. However, the mechanism of inhibition remains elusive. S-1 contains 5-chloro-2,4-dihydroxypyridine (CDHP), which does not have the antigrowth activity, but prevents the degradation of 5-fluorouracil, an anticancer reagent. In this study, we found that CDHP treatment shrinks cell morphology in metastatic basal-like breast cancer cell lines...
January 22, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29356409/scalable-synthesis-of-triple-core-shell-nanostructures-of-tio2-mno2-c-for-high-performance-supercapacitors-using-structure-guided-combustion-waves
#3
Dongjoon Shin, Jungho Shin, Taehan Yeo, Hayoung Hwang, Seonghyun Park, Wonjoon Choi
Core-shell nanostructures of metal oxides and carbon-based materials have emerged as outstanding electrode materials for supercapacitors and batteries. However, their synthesis requires complex procedures that incur high costs and long processing times. Herein, a new route is proposed for synthesizing triple-core-shell nanoparticles of TiO2 @MnO2 @C using structure-guided combustion waves (SGCWs), which originate from incomplete combustion inside chemical-fuel-wrapped nanostructures, and their application in supercapacitor electrodes...
January 22, 2018: Small
https://www.readbyqxmd.com/read/29356399/sall4-khdrbs3-network-enhances-stemness-by-modulating-cd44-splicing-in-basal-like-breast-cancer
#4
Yoshiaki Matsumoto, Junji Itou, Fumiaki Sato, Masakazu Toi
Understanding the mechanism by which cancer cells enhance stemness facilitates cancer therapies. Here, we revealed that a stem cell transcription factor, SALL4, functions to enhance stemness in basal-like breast cancer cells. We used shRNA-mediated knockdown and gene overexpression systems to analyze gene functions. To evaluate stemness, we performed a sphere formation assay. In SALL4 knockdown cells, the sphere formation ability was reduced, indicating that SALL4 enhances stemness. CD44 is a membrane protein and is known as a stemness factor in cancer...
January 22, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29356398/detection-of-peroxyl-radicals-from-polluted-air-by-free-radical-reaction-combined-with-liquid-chromatography-signal-amplification-technique
#5
Guoying Wang, Yanrong Liu, Xiuli Niu, Shiming Jia, Haoqi Tian, Xuefu Chen, Gaofeng Shi
Free radicals play an important role in the oxidizing power of the polluted air, the development of aging-related diseases, the formation of ozone, and the production of secondary particulate matters. The high variability of peroxyl radical concentration has prevented the detection of possible trends or distributions in the concentration of those species. We present a new method, free radical reaction combined with liquid chromatography photodiode array detection, for identifying and quantifying peroxyl radicals in polluted air...
January 22, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29356370/prevalence-and-risk-factors-for-problematic-internet-use-among-rural-adolescents-in-korea
#6
Ju-Yeon Lee, Seon-Young Kim, Kyung-Yeol Bae, Jae-Min Kim, Il-Seon Shin, Jin-Sang Yoon, Sung-Wan Kim
INTRODUCTION: The number of Internet users is increasing dramatically due to high-speed Internet connections and the use of cellular Internet service among rural adolescents in Korea. This study examined the prevalence of problematic Internet use (PIU) and factors associated with PIU among rural adolescents in Korea. METHODS: In total, 1168 adolescents aged 13 to 18 years from a rural area in Korea participated in this cross-sectional school survey. Problematic Internet use was categorized with Young's Internet Addiction Test using a validated cutoff...
January 21, 2018: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/29356365/risk-network-approaches-to-locating-undiagnosed-hiv-cases-in-odessa-ukraine
#7
Pavlo Smyrnov, Leslie D Williams, Ania Korobchuk, Yana Sazonova, Georgios K Nikolopoulos, Britt Skaathun, Ethan Morgan, John Schneider, Tetyana I Vasylyeva, Samuel R Friedman
INTRODUCTION: Providing HIV healthcare and Treatment as Prevention both depend on diagnosing HIV cases, preferably soon after initial infection. We hypothesized that tracing risk networks recruits higher proportions of undiagnosed positives than outreach-based testing or respondent-driven sampling (RDS) in Odessa, Ukraine. METHODS: The Transmission Reduction Intervention Project (TRIP) used risk network tracing to recruit sexual and injection networks of recently-infected and longer-term infected (LTs) seeds (2013 to 2016)...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29356355/improving-hemocompatibility-of-membranes-for-extracorporeal-membrane-oxygenators-by-grafting-nonthrombogenic-polymer-brushes
#8
Fabian Obstals, Mariia Vorobii, Tomáš Riedel, Andres de Los Santos Pereira, Michael Bruns, Smriti Singh, Cesar Rodriguez-Emmenegger
Nonthrombogenic modifications of membranes for extracorporeal membrane oxygenators (ECMOs) are of key interest. The absence of hemocompatibility of these membranes and the need of anticoagulation of patients result in severe and potentially life-threatening complications during ECMO treatment. To address the lack of hemocompatibility of the membrane, surface modifications are developed, which act as barriers to protein adsorption on the membrane and, in this way, prevent activation of the coagulation cascade...
January 22, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29356353/effect-of-the-prevent-alcohol-and-risk-related-trauma-in-youth-p-a-r-t-y-program-among-senior-school-students
#9
Anna Gunn, Janet McLeod, Rebecca Chapman, Hayley Ball, Mark Fitzgerald, Teresa Howard, Peter Cameron, Biswadev Mitra
OBJECTIVE: The Prevent Alcohol and Risk-Related Trauma in Youth (P.A.R.T.Y.) Program at The Alfred uses vivid clinical reality to build resilience and prevent injury by following a trauma patient's journey through hospital. The present study aims to analyse the effect of P.A.R.T.Y. on safety perceptions of driving after alcohol, seat belt use and risk-taking activities. METHODS: Pre-programme, immediately post-programme and 3-5 months post-programme surveys with questions focused on the programme aims were distributed to all consented participants...
January 21, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29356340/overweight-or-underweight-and-the-risk-of-decline-in-activities-of-daily-living-in-a-22-year-cohort-study-of-a-japanese-sample
#10
Shohei Okamoto, Tomonori Okamura, Daisuke Sugiyama, Takehito Hayakawa, Yasuyuki Nakamura, Naoko Miyagawa, Shuji Kurita, Naoyuki Takashima, Takayoshi Ohkubo, Aya Kadota, Akira Fujiyoshi, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
AIM: The present study aimed to clarify the association between body mass index (BMI) and the activities of daily living (ADL). Although BMI is likely to be concerned regarding the relationship with specific diseases or mortality, few studies have focused on the relationship of BMI and ADL. METHODS: A total of 3353 Japanese participants of a 22-year cohort study from 1990 to 2012 aged 45-74 years at baseline were divided into four groups according to their BMI levels: ≤18...
January 22, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29356280/potential-role-of-potassium-and-chloride-channels-in-regulation-of-silymarin-induced-apoptosis-in-candida-albicans
#11
Wonjong Lee, Dong Gun Lee
Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver diseases. In our previous study, we reported that at concentrations above the minimal inhibitory concentration (MIC), silymarin exhibited antifungal activity against Candida albicans by targeting its plasma membrane. However, the antifungal mechanism at concentration below the MIC remains unknown. Therefore, we aimed to determine the underlying mechanism of antifungal effects of silymarin at concentration below the MIC...
January 22, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29356267/cleavable-crosslinkers-as-tissue-fixation-reagents-for-proteomic-analysis
#12
Sara Ongay, Miriam Langelaar-Makkinje, Marcel P Stoop, Nora Liu, Hermen Overkleeft, Theo M Luider, Geny M M Groothuis, Rainer Bischoff
Formaldehyde fixation is widely used for long-term storage of tissue. However, due to formaldehyde-induced cross-links, fixated tissue proteins are difficult to extract hampering mass spectrometry (MS)-proteomic analyses. In the present work we evaluate cleavable protein crosslinkers as fixatives that allow tissue preservation as well as efficient protein extraction for MS-proteomics under mild conditions. We investigated disuccinimidyl tartrate (DST) and dithiobis[succinimidylpropionate] (DSP) as cleavable fixating reagents...
January 22, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29356253/current-protein-and-amino-acid-intakes-among-japanese-people-analysis-of-the-2012-national-health-and-nutrition-survey
#13
Kazuko Ishikawa-Takata, Hidemi Takimoto
AIM: To evaluate protein and amino acid intakes and distribution among Japanese people in terms of prevention of sarcopenia or frailty. METHODS: We carried out a cross-sectional study using data from Japan's 2012 National Health and Nutrition Survey. From the original dataset, we selected individuals aged ≥30 years, who were not pregnant or lactating, and for whom dietary intake, bodyweight and body height data were available. Protein intake was calculated using exclusive software developed for the survey...
January 22, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29356224/sauchinone-prevents-il-1%C3%AE-induced-inflammatory-response-in-human-chondrocytes
#14
Yanjun Gao, Hongyu Zhao, Yang Li
Sauchinone is one of the active lignan isolated from Saururus chinensis, which has been considered to possess various pharmacological activities, such as antitumor, hepatoprotective, antioxidant, and anti-inflammatory effects. However, the functional roles of sauchinone in interleukin-1 beta (IL-1β)-stimulated human osteoarthritis (OA) chondrocytes are still unknown. Thus, in this study, we investigated the anti-inflammatory effects of sauchinone in IL-1β-stimulated chondrocytes. Our results demonstrated that sauchinone significantly attenuated NO and PGE2 production, as well as inhibited iNOS and COX-2 expression in IL-1β-stimulated OA chondrocytes...
January 22, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29356222/lack-of-actpk1-an-sty-kinase-enhances-ammonium-uptake-and-use-and-promotes-growth-of-rice-seedlings-under-sufficient-external-ammonium
#15
Marcel Pascal Beier, Mitsuhiro Obara, Akiko Taniai, Yuki Sawa, Jin Ishizawa, Haruki Yoshida, Narumi Tomita, Tsuyoshi Yamanaka, Yawara Ishizuka, Syuko Kudo, Akira Yoshinari, Shiho Takeuchi, Soichi Kojima, Tomoyuki Yamaya, Toshihiko Hayakawa
Ammonium influx into plant roots via the high-affinity transport system (HATS) is down-modulated under elevated external ammonium, preventing ammonium toxicity. In ammonium-fed Arabidopsis, ammonium transporter 1 (AMT1) trimers responsible for HATS activity are allosterically inactivated in a dose-dependent manner via phosphorylation of the conserved threonine at the carboxyl-tail by the calcineurin B-like protein 1-calcineurin B-like protein-interacting protein kinase 23 complex and other yet unidentified protein kinases...
January 21, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29356221/results-of-early-treatment-for-de-novo-donor-specific-antibodies-in-pediatric-kidney-transplant-recipients-in-a-cross-sectional-and-longitudinal-cohort
#16
Olga Charnaya, Shamir Tuchman, Asha Moudgil
The development of dnDSA anti-HLA antibodies has been shown to be a significant risk factor for graft failure. In 2008, we instituted a routine protocol of standardized monitoring and treatment of dnDSA in pediatric kidney transplant recipients. Of 67 first-time pediatric kidney transplant recipients, 26 (38%) developed dnDSA after 1.36 (IQ 1-2.14) years. Coefficient of variance of tacrolimus, a surrogate marker of non-adherence, was found to be the single most important risk factor for dnDSA development. Overall, there was a significant reduction in dnDSA with treatment in 19 (76%) children...
January 22, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29356215/appearance-based-interventions-to-reduce-uv-exposure-a-systematic-review
#17
Sofia Persson, Yael Benn, Katie Dhingra, David Clark-Carter, Alison L Owen, Sarah Grogan
PURPOSE: As a majority of skin cancer cases are behaviourally preventable, it is crucial to develop effective strategies to reduce UV exposure. Health-focused interventions have not proved to be sufficiently effective, and it has been suggested that people might be more susceptible to information about the negative effects of the sun on their appearance. METHOD: This systematic review of 30 separate papers, reporting 33 individual studies published between 2005 and 2017, assesses the overall effectiveness of appearance interventions on participants' UV exposure and sun protection behaviour...
January 22, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29356190/decreased-superficial-surgical-site-infections-shortened-hospital-stay-and-improved-quality-of-live-due-to-incisional-negative-pressure-wound-therapy-after-reversal-of-double-loop-ileostomy-improved-wound-healing-due-to-incisional-negative-pressure-wound-therapy
#18
Daniel Poehnert, Nils Hadeler, Harald Schrem, Alexander Kaltenborn, Juergen Klempnauer, Markus Winny
This single-center prospective, controlled observational study investigates the impact of incisional negative pressure wound therapy on wound healing processes and its potency to prevent superficial surgical site infections after reversal of a double loop ileostomy. Furthermore, this study gains insight in socio-economic aspects, like duration of hospital stay and, for the first time, patient's quality of life during the incisional negative pressure wound treatment. To address this question, an interventional group of 24 patients treated with incisional negative pressure wound therapy (Prevena® incisional wound management system, KCI, Germany) and a respective control cohort of 25 patients treated with a standard sterile dressing were observed for 30 days in the post-operative course...
January 22, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29356165/period-prevalence-and-reporting-rate-of-medication-errors-among-nurses-in-iran-a-systematic-review-and-meta-analysis
#19
Behzad Karami Matin, Mohammad Hajizadeh, Bijan Nouri, Shahab Rezaeian, Masoud Mohammadi, Satar Rezaei
AIMS: To estimate the 1-year period prevalence of medication errors and the reporting rate to nurse managers among nurses working in hospitals in Iran. BACKGROUND: Medication errors are one of the main factors affecting the quality of hospital services and reducing patient safety in health care systems. METHOD: A literature search from Iranian and international scientific databases was developed to find relevant studies. Meta-regression was used to identify which characteristics may have a confounding effect on the pooled prevalence estimates...
January 22, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29356078/diabetes-and-technology-in-2030-a-utopian-or-dystopian-future
#20
D Kerr, C Axelrod, C Hoppe, D C Klonoff
The ability of an individual living with diabetes to have human-to-human contact with their healthcare provider is not keeping pace with the number of people developing diabetes. From a futurist perspective, however, this dichotomy of diabetes care represents an opportunity for digital healthcare. The focus of technological innovation is unlikely to be the replacement of the multidisciplinary diabetes team but rather the provision of meaningful individual and family support between clinic visits and, on a larger scale, the facilitation of population health management for diabetes...
January 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
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