Vanessa Azevedo Voltarelli, Rodrigo W Alves de Souza, Kenji Miyauchi, Carl J Hauser, Leo Edmond Otterbein
Heme is an iron-protoporphyrin complex with an essential physiologic function for all cells, especially for those in which heme is a key prosthetic group of proteins such as hemoglobin, myoglobin, and cytochromes of the mitochondria. However, it is also known that heme can participate in pro-oxidant and pro-inflammatory responses, leading to cytotoxicity in various tissues and organs such as the kidney, brain, heart, liver, and in immune cells. Indeed, heme, released as a result of tissue damage, can stimulate local and remote inflammatory reactions...
May 10, 2023: Antioxidants (Basel, Switzerland)