keyword
MENU ▼
Read by QxMD icon Read
search

Myoglobin kidney

keyword
https://www.readbyqxmd.com/read/28836571/pharmacological-inhibition-of-macrophage-toll-like-receptor-4-nuclear-factor-kappa-b-alleviates-rhabdomyolysis-induced-acute-kidney-injury
#1
Rong-Shuang Huang, Jiao-Jiao Zhou, Yu-Ying Feng, Min Shi, Fan Guo, Shen-Ju Gou, Stephen Salerno, Liang Ma, Ping Fu
BACKGROUND: Acute kidney injury (AKI) is the most common and life-threatening systemic complication of rhabdomyolysis. Inflammation plays an important role in the development of rhabdomyolysis-induced AKI. This study aimed to investigate the kidney model of AKI caused by rhabdomyolysis to verify the role of macrophage Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway. METHODS: C57BL/6 mice were injected with a 50% glycerin solution at bilateral back limbs to induce rhabdomyolysis, and CLI-095 or pyrrolidine dithiocarbamate (PDTC) was intraperitoneally injected at 0...
August 21, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28811700/primary-myoglobinuria-differentiate-myoglobinuria-from-hemoglobinuria
#2
Dhiraj J Trivedi, Shrirang P Kulkarni, Rakesh Mudaraddi
Myoglobin is dark red colour heme containing protein, stored in muscle. Change in permeability of myolemma causes myoglobin leak in plasma, which is cleared by kidney swiftly. Differentiating myoglobinuria from hemoglobinuria is important. Clinicians concern over myoglobinuria is to protect the patient from acute renal disease. We present a case of primary myoglobinuria, its clinical symptoms, diagnosis and treatment.
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28704479/dynamic-changes-in-bach1-expression-in-the-kidney-of-rhabdomyolysis-associated-acute-kidney-injury
#3
Masakazu Yamaoka, Hiroko Shimizu, Toru Takahashi, Emiko Omori, Hiroshi Morimatsu
Free heme, a pro-oxidant released from myoglobin, is thought to contribute to the pathogenesis of rhabdomyolysis-associated acute kidney injury (RM-AKI), because renal overexpression of heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, confers protection against RM-AKI. BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that represses HO-1. Here, we examined the changes with time in the gene expression of Bach1, HO-1, and δ-aminolevulinate synthase (ALAS1, a heme biosynthetic enzyme) in the rat kidney using an RM-AKI model induced by the injection of 50% glycerol (10 mL/kg body weight) into bilateral limbs...
2017: PloS One
https://www.readbyqxmd.com/read/28668175/adverse-effects-of-the-renal-accumulation-of-haem-proteins-novel-therapeutic-approaches
#4
Melania Guerrero-Hue, Alfonso Rubio-Navarro, Ángel Sevillano, Claudia Yuste, Eduardo Gutiérrez, Alejandra Palomino-Antolín, Elena Román, Manuel Praga, Jesús Egido, Juan Antonio Moreno
Haemoglobin and myoglobin are haem proteins that play a key role as they help transport oxygen around the body. However, because of their chemical structure, these molecules can exert harmful effects when they are released massively into the bloodstream, as reported in certain pathological conditions associated with rhabdomyolysis or intravascular haemolysis. Once in the plasma, these haem proteins can be filtered and can accumulate in the kidney, where they become cytotoxic, particularly for the tubular epithelium, inducing acute kidney failure and chronic kidney disease...
June 28, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28610806/heart-failure-in-patients-with-kidney-disease-and-iron-deficiency-the-role-of-iron-therapy
#5
Aleix Cases Amenós, Raquel Ojeda López, José María Portolés Pérez
Chronic kidney disease and anaemia are common in heart failure (HF) and are associated with a worse prognosis in these patients. Iron deficiency is also common in patients with HF and increases the risk of morbidity and mortality, regardless of the presence or absence of anaemia. While the treatment of anaemia with erythropoiesis-stimulating agents in patients with HF have failed to show a benefit in terms of morbidity and mortality, treatment with IV iron in patients with HF and reduced ejection fraction and iron deficiency is associated with clinical improvement...
June 10, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28609447/blood-biomarkers-in-male-and-female-participants-after-an-ironman-distance-triathlon
#6
Tom Danielsson, Jörg Carlsson, Hendrik Schreyer, Jonas Ahnesjö, Lasse Ten Siethoff, Thony Ragnarsson, Åsa Tugetam, Patrick Bergman
BACKGROUND: While overall physical activity is clearly associated with a better short-term and long-term health, prolonged strenuous physical activity may result in a rise in acute levels of blood-biomarkers used in clinical practice for diagnosis of various conditions or diseases. In this study, we explored the acute effects of a full Ironman-distance triathlon on biomarkers related to heart-, liver-, kidney- and skeletal muscle damage immediately post-race and after one week's rest...
2017: PloS One
https://www.readbyqxmd.com/read/28586635/tin-protoporphyrin-activates-the-oxidant-dependent-nrf2-cytoprotective-pathway-and-mitigates-acute-kidney-injury
#7
Ali C M Johnson, Jeff J Delrow, Richard A Zager
Tin protoporphyrin (SnPP), a heme oxygenase (HO) inhibitor, can paradoxically protect against diverse forms of acute kidney injury (AKI). This study sought potential underlying mechanisms. CD-1 mice received intravenous SnPP, followed 4-18 hours later by a variety of renal biochemical, histologic, and genomic assessments. Renal resistance to ischemic-reperfusion injury (IRI) was also sought. SnPP was rapidly taken up by kidney and was confined to proximal tubules. Transient suppression of renal heme synthesis (decreased δ aminolevulinic acid synthase expression), a 2...
May 19, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28564273/kidney-transplantation-from-donors-with-rhabdomyolysis-and-acute-renal-failure
#8
Chuan-Bao Chen, Yi-Tao Zheng, Jian Zhou, Ming Han, Xiao-Ping Wang, Xiao-Peng Yuan, Chang-Xi Wang, Xiao-Shun He
Rhabdomyolysis in deceased donors usually causes acute renal failure (ARF), which may be considered a contraindication for kidney transplantation. From January 2012 to December 2016, 30 kidneys from 15 deceased donors with severe rhabdomyolysis and ARF were accepted for transplantation at our center. The peak serum creatinine (SCr) kinase, myoglobin, and SCr of the these donors were 15 569±8597 U/L, 37 092±42 100 μg/L, and 422±167 μmol/L, respectively. Two donors received continuous renal replacement therapy due to anuria...
August 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28340139/assessment-of-acute-kidney-injury-in-rhabdomyolytic-mice-by-transcutaneous-measurement-of-sinistrin-excretion
#9
Aldo Moggio, Stefania Geraci, Alberto Boido, Carsten Sticht, Norbert Gretz, Benedetta Bussolati
Background: Early and accurate assessment of renal function is required for the successful detection and treatment of acute kidney injury (AKI). However, only retention parameters such as plasma urea and creatinine, and the indirect estimation of glomerular filtration rate are commonly available. Methods: Here, we measured the kinetics of plasma fluorescein isothiocyanate (FITC)-sinistrin excretion to detect alterations of renal function over time in a murine model of rhabdomyolysis-induced AKI...
July 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28252561/successful-transplantation-of-2-discolored-kidneys-caused-by-myoglobin-casts-from-a-donor-with-rhabdomyolysis
#10
Chuan-Bao Chen, Jian Zhou, Xiao-Ping Wang, Ming Han, Wen-Fang Chen, Xiao-Peng Yuan
No abstract text is available yet for this article.
March 1, 2017: Transplantation
https://www.readbyqxmd.com/read/28235546/non-traumatic-rhabdomyolysis-background-laboratory-features-and-acute-clinical-management
#11
REVIEW
Gianfranco Cervellin, Ivan Comelli, Mario Benatti, Fabian Sanchis-Gomar, Antonella Bassi, Giuseppe Lippi
Rhabdomyolysis is a relatively rare condition, but its clinical consequences are frequently dramatic in terms of both morbidity and mortality. Although no consensus has been reached so far about the precise definition of this condition, the term rhabdomyolysis describes a rapid breakdown of striated, or skeletal, muscle. It is hence characterized by the rupture and necrosis of muscle fibers, resulting in release of cell degradation products and intracellular elements within the bloodstream and extracellular space...
August 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28117405/biological-membrane-packed-mesenchymal-stem-cells-treat-acute-kidney-disease-by-ameliorating-mitochondrial-related-apoptosis
#12
Xiaodong Geng, Quan Hong, Weiwei Wang, Wei Zheng, Ou Li, Guangyan Cai, Xiangmei Chen, Di Wu
The mortality of rhabdomyolysis-induced AKI remains high because no effective therapy exists. We investigated a new therapeutic method using MSCs. The aim of this study was to investigate the therapeutic potential and anti-apoptotic mechanisms of action of MSCs in the treatment of AKI induced by glycerol in vivo and in vitro. We used Duragen as a biological membrane to pack MSCs on the glycerol-injured renal tissue in vivo. The anti-apoptotic mechanism was investigated. In vitro, HK-2 cells were incubated with ferrous myoglobin and MSCs-conditioned medium, followed by cell proliferation and apoptosis assays...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096432/effects-of-activity-genetic-selection-and-their-interaction-on-muscle-metabolic-capacities-and-organ-masses-in-mice
#13
Scott A Kelly, Fernando R Gomes, Erik M Kolb, Jessica L Malisch, Theodore Garland
Chronic voluntary exercise elevates total daily energy expenditure and food consumption, potentially resulting in organ compensation supporting nutrient extraction/utilization. Additionally, species with naturally higher daily energy expenditure often have larger processing organs, which may represent genetic differences and/or phenotypic plasticity. We tested for possible adaptive changes in organ masses of four replicate lines of house mice selected (37 generations) for high running (HR) compared with four non-selected control (C) lines...
March 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28065770/risk-of-colchicine-associated-myopathy-in-gout-influence-of-concomitant-use-of-statin
#14
Oh Chan Kwon, Seokchan Hong, Byeongzu Ghang, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo
OBJECTIVE: The purpose of this study was to investigate the risk of myopathy when statins are coadministered with colchicine in patients with gout. METHODS: In gout patients who received colchicine with or without statin, clinical data collected included medications and history of hypertension, chronic kidney disease, and liver cirrhosis. Myopathy was defined as the presence of muscle symptoms with elevated creatine kinase or myoglobin. Multivariate analysis was performed to identify risk factors for myopathy...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28052871/myoglobin-facilitates-angiotensin-ii-induced-constriction-of-renal-afferent-arterioles
#15
Z Z Liu, S Mathia, T Pahlitzsch, I C Wennysia, P B Persson, E Y Lai, A Högner, M Z Xu, R Schubert, C Rosenberger, A Patzak
Vasoconstriction plays an important role in the development of acute kidney injury in rhabdomyolysis. We hypothesized that myoglobin enhances the angiotensin II (ANG II) response in afferent arterioles by increasing superoxide and reducing nitric oxide (NO) bioavailability. Afferent arterioles of C57Bl6 mice were isolated perfused, and vasoreactivity was analyzed using video microscopy. NO bioavailability, superoxide concentration in the vessel wall, and changes in cytosolic calcium were measured using fluorescence techniques...
May 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27951574/clinical-performance-assessment-of-cordiax-filters-in-hemodialysis-and-hemodiafiltration
#16
Jacky Potier, Sudhir Bowry, Bernard Canaud
In this study, we evaluate the in vivo clinical performances of CorDiax FX 100 and CorDiax FX 1000 filters incorporating a high-flux membrane (Helixone Plus) designed for use in high-flux hemodialysis (HD) as well as in hemodiafiltration (HDF) in 6 stable end-stage kidney disease patients. In the HDF mode, various substitution modalities (post-, pre-, and mixed) were compared. In addition to conventional markers of efficacy of dialysis dose (urea, ionic dialysance, Kt/V), several additional middle- and large-size solute (β2-microglobulin, myoglobin, serum-free light-chain kappa and lambda, α1-microglobulin, and FGF23) compounds were explored in order to cover the spectrum of uremic toxins that are involved in uremia...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/27942176/identification-of-urinary-proteins-potentially-associated-with-diabetic-kidney-disease
#17
R K Marikanty, M K Gupta, S V B Cherukuvada, S S S Kompella, A K Prayaga, S Konda, R V Polisetty, M M Idris, P V Rao, G R Chandak, K V Dakshinamurty
Diabetic nephropathy (DN) is the most common cause of chronic kidney disease. Although several parameters are used to evaluate renal damage, in many instances, there is no pathological change until damage is already advanced. Mass spectrometry-based proteomics is a novel tool to identify newer diagnostic markers. To identify urinary proteins associated with renal complications in diabetes, we collected urine samples from 10 type 2 diabetes patients each with normoalbuminuria, micro- and macro-albuminuria and compared their urinary proteome with that of 10 healthy individuals...
November 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27941593/low-dose-sodium-nitrite-fluid-resuscitation-prevents-lethality-from-crush-syndrome-by-improving-nitric-oxide-consumption-and-preventing-myoglobin-cytotoxicity-in-kidney-in-a-rat-model
#18
Isamu Murata, Yumi Miyake, Naomi Takahashi, Ryuta Suzuki, Takayuki Fujiwara, Yuji Sato, Yutaka Inoe, Jun Kobayashi, Ikuo Kanamoto
OBJECTIVE: Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from pressure. CS has a high mortality, even when patients receive fluid therapy. We examined whether administration of NaNO2-containing fluid can improve survival in a rat model of CS. DESIGN: The CS model was generated by subjecting anesthetized rats to bilateral hind limb compression with a rubber tourniquet for 5 h. Rats were then randomly divided into six groups: (i) sham; (ii) CS with no treatment; (iii) CS with normal saline treatment; (iv) CS with normal saline + 25 mEq/L bicarbonate treatment; and (v and vi) CS with normal saline + 200 or 500 μmol/kg NaNO2...
December 9, 2016: Shock
https://www.readbyqxmd.com/read/27864544/investigative-nonclinical-cardiovascular-safety-and-toxicology-studies-with-bms-986094-an-ns5b-rna-dependent-rna-polymerase-inhibitor
#19
M Gill, K Horn, J Hennan, R White, D Bounous, S Clark, J R Megill, E Janovitz, M Davies, T Sanderson, M Graziano
BMS-986094, a 2'-C-methylguanosine prodrug that was in development for treatment of chronic hepatitis C infection was withdrawn from Phase 2 clinical trials because of unexpected cardiac and renal adverse events. Investigative nonclinical studies were conducted to extend the understanding of these findings using more comprehensive endpoints. BMS-986094 was given orally to female CD-1 mice (25 and 150 mg/kg/d) for 2 weeks (53/group) and to cynomolgus monkeys (15 and 30 mg/kg/d) for up to 6 weeks (2-3/sex/group for cardiovascular safety, and 5/sex/group for toxicology)...
November 17, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27734446/exertional-rhabdomyolysis-epidemiology-diagnosis-treatment-and-prevention
#20
Joseph J Knapik, Francis G O'Connor
Exertional rhabdomyolysis (ER) is a medical condition whereby damage to skeletal muscle is induced by excessive physical activity in otherwise healthy individuals. The individual performs so much activity that he/ she presumably depletes local muscle energy stores and muscle cells are unable to maintain cellular integrity, resulting in cell damage and the release of cellular contents, with resultant secondary complications. In the military services, the incidence of ER appeared to increase in the period 2004 to 2015...
December 0: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
keyword
keyword
13833
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"