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https://www.readbyqxmd.com/read/29217665/critical-determinants-of-combined-sprint-and-endurance-performance-an-integrative-analysis-from-muscle-fiber-to-the-human-body
#1
Stephan van der Zwaard, Willem J van der Laarse, Guido Weide, Frank W Bloemers, Mathijs J Hofmijster, Koen Levels, Dionne A Noordhof, Jos J de Koning, Cornelis J de Ruiter, Richard T Jaspers
Optimizing physical performance is a major goal in current physiology. However, basic understanding of combining high sprint and endurance performance is currently lacking. This study identifies critical determinants of combined sprint and endurance performance using multiple regression analyses of physiologic determinants at different biologic levels. Cyclists, including 6 international sprint, 8 team pursuit, and 14 road cyclists, completed a Wingate test and 15-km time trial to obtain sprint and endurance performance results, respectively...
December 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29216252/global-computational-mutagenesis-provides-a-critical-stability-framework-in-protein-structures
#2
Caitlyn L McCafferty, Yuri V Sergeev
A protein's amino acid sequence dictates the folds and final structure the macromolecule will form. We propose that by identifying critical residues in a protein's atomic structure, we can select a critical stability framework within the protein structure essential to proper protein folding. We use global computational mutagenesis based on the unfolding mutation screen to test the effect of every possible missense mutation on the protein structure to identify the residues that cannot tolerate a substitution without causing protein misfolding...
2017: PloS One
https://www.readbyqxmd.com/read/29200908/ursolic-acid-supplementation-decreases-markers-of-skeletal-muscle-damage-during-resistance-training-in-resistance-trained-men-a-pilot-study
#3
Hyun Seok Bang, Dae Yun Seo, Young Min Chung, Do Hyung Kim, Sam-Jun Lee, Sung Ryul Lee, Hyo-Bum Kwak, Tae Nyun Kim, Min Kim, Kyoung-Mo Oh, Young Jin Son, Sanghyun Kim, Jin Han
Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial effects on exercise-induced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group)...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29198593/a-new-generation-of-cellulose-triacetate-suitable-for-online-haemodiafiltration
#4
Francisco Maduell, Raquel Ojeda, Marta Arias-Guillén, Néstor Fontseré, Manel Vera, Lida Rodas, Miquel Gómez, Karen P Huablocho, Fanny Esquivel, Paola D Mori, Valentina Hoffmann, Jessica Ugalde, Nayra Rico
BACKGROUND: Online haemodiafiltration (OL-HDF) is currently the most effective dialysis technique that also improves survival. To date, high permeability membranes with low albumin loss, such as polysulfone, polyamide and polyacrylonitrile membranes have been the most widely used. However, the initially restricted use of cellulose triacetate (CTA) membranes in OL-HDF has expanded. The aim of the study was to ascertain whether the latest generation asymmetric CTA membranes are more effective in obtaining high convective transport...
November 29, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29197256/determination-of-the-formal-redox-potentials-of-the-cyanhaemoglobin-cyanmethaemoglobin-and-the-myoglobin-metmyoglobin-couples-at-neutral-ph
#5
Leila Mahmoudi, Felix Zelder, Reinhard Kissner
Determination of a representative formal redox potential of the Fe(II)/Fe(III) redox couple in cyanhaemoglobin, at pH=7 and related to the state in solution, was the objective of this work. It was achieved at low concentrations of the protein (5μM) to circumvent undesired adsorption. Square-wave voltammetry instead of classical cyclic voltammetry was applied because this method is more sensitive and provides information on the formal redox potential and reversibility, even for rapid processes. We obtained E°'=-0...
November 27, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29189585/muscle-damage-and-metabolic-responses-to-repeated-sprint-running-with-and-without-deceleration
#6
Clare L Minahan, Daniel P Poke, Jaime Morrison, Phillip M Bellinger
This study aimed to determine whether repeated-sprint running with deceleration aggravates markers of muscle damage or delays the recovery of performance compared to repeated-sprint running without deceleration. Fourteen male team-sport athletes performed two randomly ordered testing sessions on a non-motorised treadmill with one session requiring participants to decelerate (TMd) within 4 s before stopping, or immediately step to the side of the treadmill belt at the completion of each sprint (TMa). Peak and mean velocities, speed decrement, blood lactate concentrations and oxygen uptake were monitored during the repeated-sprint running protocols...
November 16, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29182876/solid-state-hydrogen-deuterium-exchange-mass-spectrometry-correlation-of-deuterium-uptake-and-long-term-stability-of-lyophilized-monoclonal-antibody-formulations
#7
Balakrishnan S Moorthy, Isidro E Zarraga, Lokesh Kumar, Benjamin T Walters, Pierre Goldbach, Elizabeth M Topp, Andrea Allmendinger
Solid state hydrogen-deuterium exchange with mass spectrometric analysis (ssHDX-MS) has been used to assess protein conformation and matrix interactions in lyophilized solids. ssHDX-MS metrics have been previously correlated to the formation of aggregates of lyophilized myoglobin on storage. Here, ssHDX-MS was applied to lyophilized monoclonal antibody (mAb) formulations and correlated to their long-term stability. After exposing lyophilized samples to D2O(g), the amount of deuterium incorporated at various time points was determined by mass spectrometry for four different lyophilized mAb formulations...
November 28, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29173932/influence-of-intimate-partner-violence-ipv-exposure-on-cardiovascular-and-salivary-biosensors-is-there-a-relationship
#8
Leslie R Halpern, Malcolm L Shealer, Rian Cho, Elizabeth B McMichael, Joseph Rogers, Daphne Ferguson-Young, Charles P Mouton, Mohammad Tabatabai, Janet Southerland, Pandu Gangula
BACKGROUND/PURPOSE: Intimate partner violence (IPV) is a global public health epidemic that initiates/exacerbates health consequences affecting a victim's lifespan. IPV can significantly predispose women to a lifetime risk of developing cardiovascular disease (CVD) due to the effects of stress and inflammation. This study investigates the correlation among IPV exposure, in-vivo CVD events, and inflammatory biomarkers as predictor indices(s) for CVD in female dental patients. METHODS: Of 37 women enrolled in this study, 19 were African-American (AA) and 18 non-African-American (non-AA) and their ages ranged from 19 to 63 years...
January 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29170114/protein-alginate-complexes-as-ph-ion-sensitive-carriers-of-proteins
#9
Vida Rahmani, Heather Sheardown
Protein-alginate complexes were prepared with the objective of quantifying the influence of the parameters such as protein characteristics on the final complex properties and their dissociation rates. Cytochrome C, lysozyme, myoglobin, chymotrypsin, and bovine serum albumin were used as model proteins for preparing the complexes and physical properties such as composition, average diameter, and zeta potential of the complexes formed were measured. In addition, protein release kinetics from the complexes in response to changes in pH and ionic strength were investigated...
November 20, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29158437/cardiac-magnetic-resonance-imaging-in-myocarditis-reveals-persistent-disease-activity-despite-normalization-of-cardiac-enzymes-and-inflammatory-parameters-at-3-month-follow-up
#10
Jan Berg, Jan Kottwitz, Nora Baltensperger, Christine K Kissel, Marina Lovrinovic, Tarun Mehra, Frank Scherff, Christian Schmied, Christian Templin, Thomas F Lüscher, Bettina Heidecker, Robert Manka
BACKGROUND: There is a major unmet need to identify high-risk patients in myocarditis. Although decreasing cardiac and inflammatory markers are commonly interpreted as resolving myocarditis, this assumption has not been confirmed as of today. We sought to evaluate whether routine laboratory parameters at diagnosis predict dynamic of late gadolinium enhancement (LGE) as persistent LGE has been shown to be a risk marker in myocarditis. METHODS AND RESULTS: Myocarditis was diagnosed based on clinical presentation, high-sensitivity troponin T, and cardiac magnetic resonance imaging, after exclusion of obstructive coronary artery disease by angiography...
November 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29156293/fe-iii-sulfide-interaction-in-globins-characterization-and-quest-for-a-putative-fe-iv-sulfide-species
#11
Augustin C Mot, Cristina Bischin, Grigore Damian, Amr A A Attia, Emese Gal, Nicoleta Dina, Nicolae Leopold, Radu Silaghi-Dumitrescu
The present study reports findings regarding the contrast between H2S interaction with bovine hemoglobin (Hb) and horse heart myoglobin (Mb), in terms of binding and dissociation kinetics, affinities, and mechanism. At pH9.5, oxidation of ferric-sulfide adducts in presence of no free sulfide, using hexachloroiridate as oxidant is examined using stopped-flow UV-vis, EPR, vibrational spectroscopy and mass spectrometry. Oxidation of the ferric-sulfide adduct in such conditions occurs with a putative unstable Fe(IV)-sulfide adduct as intermediate that finally leads to a paramagnetic ferric species with distinct EPR features...
November 10, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29155105/functional-diversification-of-sea-lamprey-globins-in-evolution-and-development
#12
Angela Fago, Kim Rohlfing, Elin E Petersen, Agnieszka Jendroszek, Thorsten Burmester
Agnathans have a globin repertoire that markedly differs from that of jawed (gnathostome) vertebrates. The sea lamprey (Petromyzon marinus) harbors at least 18 hemoglobin, two myoglobin, two globin X, and one cytoglobin genes. However, agnathan hemoglobins and myoglobins are not orthologous to their cognates in jawed vertebrates. Thus, blood-based O2 transport and muscle-based O2 storage proteins emerged twice in vertebrates from a tissue-globin ancestor. Notably, the sea lamprey displays three switches in hemoglobin expression in its life cycle, analogous to hemoglobin switching in vertebrates...
November 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29150355/contribution-of-nitric-oxide-synthase-from-coagulase-negative-staphylococci-to-the-development-of-red-myoglobin-derivatives
#13
Geoffrey Ras, Xavier Bailly, Jean-Paul Chacornac, Véronique Zuliani, Patrick Derkx, Tim M Seibert, Régine Talon, Sabine Leroy
As part of the microbial community of meat or as starter cultures, coagulase-negative staphylococci (CNS) serve several essential technological purposes in meat products, such as color development through the reduction of nitrate to nitrite. As the safety of nitrite as an additive has been questioned, we explored the potential of CNS to develop red myoglobin derivatives such as oxymyoglobin and nitrosomyoglobin. Nitrosoheme was extracted to evaluate NO production. This production could be due to a nitric oxide synthase (NOS) activity...
November 13, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29148750/catalytic-cyclopropanation-by-myoglobin-reconstituted-with-iron-porphycene-acceleration-of-catalysis-due-to-rapid-formation-of-the-carbene-species
#14
Koji Oohora, Hiroyuki Meichin, Liming Zhao, Matthew W Wolf, Akira Nakayama, Jun-Ya Hasegawa, Nicolai Lehnert, Takashi Hayashi
Myoglobin reconstituted with iron porphycene catalyzes the cyclopropanation of styrene with ethyl diazoacetate. Compared to native myoglobin, the reconstituted protein significantly accelerates the catalytic reaction and the kcat/Km value is 26-fold enhanced. Mechanistic studies indicate that the reaction of the reconstituted protein with ethyl diazoacetate is 615-fold faster than that of native myoglobin. The metallocarbene species reacts with styrene with the apparent second-order kinetic constant of 28 mM-1s-1 at 25 °C...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29147095/histochemical-characteristics-in-relation-to-meat-quality-traits-of-eight-major-muscles-from-hanwoo-steers
#15
Sung-Hyun Joo, Kyu-Won Lee, Young-Hwa Hwang, Seon-Tea Joo
The objective of this study was to determine the relationship between composition of muscle fiber types and meat quality traits of eight major muscles from Hanwoo steers. Longissimus lumborum (LL), psoas major (PM), semimembranosus (SM), semitendinosus (ST), gluteus medius (GM), triceps brachii (TB), rectus abdominis (RA) and superficialis flexor (SF) muscles were obtained from 9 Hanwoo steers and subjected to histochemical analysis. There were significant (p<0.05) differences in fiber number percentage (FNP) and fiber area percentage (FAP) of fiber types among these 8 major muscles...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29143665/cardiopulmonary-and-inflammatory-biomarkers-in-heartworm-disease
#16
REVIEW
Elena Carretón, Rodrigo Morchón, José Alberto Montoya-Alonso
In heartworm disease, several biomarkers of cardiopulmonary injury and inflammatory activity have been studied during the recent years. D-dimer is a fibrin degradation product present after a clot is degraded, which has been reported to provide support for the diagnosis of pulmonary thromboembolism in heartworm disease. Furthermore, concentrations increment with increased disease severity and during the adulticide treatment. This increase in concentration has proved to be valuable. Cardiac biomarkers troponin I, myoglobin and NT-proBNP demonstrated presence of myocardial injury and heart failure, especially in chronic infections, which in some cases, slightly improve after the adulticide treatment...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29140910/polygenic-profile-and-exercise-induced-muscle-damage-by-a-competitive-half-ironman
#17
Juan Del Coso, Juan J Salinero, Beatriz Lara, César Gallo-Salazar, Francisco Areces, David Herrero, Carlos Puente
Del Coso, J, Salinero, JJ, Lara, B, Gallo-Salazar, C, Areces, F, Herrero, D, and Puente, C. Polygenic profile and exercise-induced muscle damage by a competitive half-ironman. J Strength Cond Res XX(X): 000-000, 2017-To date, it is still unknown why some individuals develop higher levels of muscle damage than other individuals, despite participating in exercise with comparable levels of physical intensity. The aim of this investigation was to analyze 7 single-nucleotide polymorphisms (SNPs) that are candidates to explain individual variations in the level of muscle damage attained during a half-ironman competition...
November 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29137079/treatment-of-hypermyoglobinemia-after-crs-hipec-for-patients-with-peritoneal-carcinomatosis-a-retrospective-comparative-study
#18
Gang Liu, Zhong-He Ji, Yang Yu, Xin-Bao Li, Yan-Bin Zhang, Kai-Wen Peng, Yan Li
This retrospective comparative study aims to explore the time courses of serum myoglobin (Mb) changes, and summarize our experience in treating patients with hypermyoglobinemia after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).This study covered 60 patients with peritoneal carcinomatosis treated with CRS + HIPEC as the study group, and another 25 cancer patients treated with conventional extensive surgery without HIPEC as the control group from February to October 2016...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136023/modifications-of-hemoglobin-and-myoglobin-by-maillard-reaction-products-mrps
#19
Aristos Ioannou, Constantinos Varotsis
High performance liquid chromatography (HPLC) coupled with a Fraction Collector was employed to isolate Maillard reaction products (MRPs) formed in model systems comprising of asparagine and monosaccharides in the 60-180°C range. The primary MRP which is detected at 60°C is important for Acrylamide content and color/aroma development in foods and also in the field of food biotechnology for controlling the extent of the Maillard reaction with temperature. The discrete fractions of the reaction products were reacted with Hemoglobin (Hb) and Myoglobin (Mb) at physiological conditions and the reaction adducts were monitored by UV-vis and Attenuated Total Reflection-Fourier transform infrared (FTIR) spectrophotometry...
2017: PloS One
https://www.readbyqxmd.com/read/29135024/reverse-stability-kinetics-of-meat-pigment-oxidation-in-aqueous-extract-from-fresh-beef
#20
John C Frelka, David M Phinney, Macdonald P Wick, Dennis R Heldman
The use of kinetic models is an evolving approach to describing quality changes in foods during processes, including storage. Previous studies indicate that the oxidation rate of myoglobin is accelerated under frozen storage conditions, a phenomenon termed reverse stability. The goal of this study was to develop a model for meat pigment oxidation to incorporate the phenomenon of reverse stability. In this investigation, the model system was an aqueous extract from beef which was stored under a range of temperatures, both unfrozen and frozen...
November 14, 2017: Journal of Food Science
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