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https://www.readbyqxmd.com/read/28432022/a-crosstalk-between-muscarinic-and-crf2-receptors-regulates-cellular-adhesion-properties-of-human-colon-cancer-cells
#1
M Pelissier-Rota, N T Chartier, B Bonaz, M R Jacquier-Sarlin
Patients with inflammatory bowel disease often suffer from chronic and relapsing intestinal inflammation that favor the development of colitis associated cancer. An alteration of the epithelial intestinal barrier function observed in IBD is supposed to be a consequence of stress. It has been proposed that corticotrophin-releasing factor receptor (CRF2), one of the two receptors of CRF, the principal neuromediator of stress, acts on cholinergic nerves to induce stress-mediated epithelial barrier dysfunction...
April 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28430332/relationship-between-corneal-biomechanical-properties-and-optic-nerve-head-changes-after-deep-sclerectomy
#2
Laura Díez-Álvarez, Francisco J Muñoz-Negrete, Pilar Casas-Llera, Noelia Oblanca, Victoria de Juan, Gema Rebolleda
PURPOSE: To evaluate corneal biomechanical properties and optic nerve head (ONH) changes following deep sclerectomy (DS) and the relation to each other. METHODS: Forty-nine eyes with primary open-angle glaucoma that underwent DS were studied. Corneal biomechanical properties were assessed using the Ocular Response Analyzer and the ONH was evaluated by Spectralis optical coherence tomography with enhanced depth imaging technology before surgery and 3 months postoperatively...
April 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28429110/inhibition-of-the-crf1-receptor-influences-the-activity-of-antidepressant-drugs-in-the-forced-swim-test-in-rats
#3
Andrzej Wróbel, Anna Serefko, Aleksandra Szopa, Karol Rojek, Ewa Poleszak, Krystyna Skalicka-Woźniak, Jarosław Dudka
Hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA) and impairment of the central corticotropin-releasing factor (CRF) system are factors in the pathogenesis of depression. Though several antagonists of the CRF1 receptor were effective in the recognized behavioral tests for antidepressant activity, there is still little information on the potential interactions between CRF1 receptor inhibitors and conventional antidepressant therapy. The aim of our study was to assess the influence of SN003, a CRF1 receptor blocker, on the activity of imipramine and fluoxetine in the forced swim test (FST) in rats which presented some signs of depression...
April 20, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28422671/structured-learning-of-tree-potentials-in-crf-for-image-segmentation
#4
Fayao Liu, Guosheng Lin, Ruizhi Qiao, Chunhua Shen
We propose a new approach to image segmentation, which exploits the advantages of both conditional random fields (CRFs) and decision trees. In the literature, the potential functions of CRFs are mostly defined as a linear combination of some predefined parametric models, and then, methods, such as structured support vector machines, are applied to learn those linear coefficients. We instead formulate the unary and pairwise potentials as nonparametric forests--ensembles of decision trees, and learn the ensemble parameters and the trees in a unified optimization problem within the large-margin framework...
April 13, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28418869/development-of-a-taiwan-cancer-related-fatigue-cognition-questionnaire-reliability-and-validity
#5
Shih-Chiung Lai, Wei-Chun Lin, Chien-Hsin Chen, Szu-Yuan Wu
PURPOSE: We prospectively designed a Taiwan cancer-related fatigue cognition questionnaire, version 1.0 (TCRFCQ-V1.0), for Taiwanese patients with cancer and investigated the reliability and validity of this questionnaire. RESULTS: The completion rate of the TCRFCQ-V1.0 was high (97% of the patients completed all items), and the rate of missing data was low (0.2%-1.1% for each item). Moreover, the Cronbach alpha value was 0.889. We eliminated 5 items because their respective Cronbach alpha values were higher than the total mean value of Cronbach's alpha...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415143/cardiorespiratory-fitness-and-health-related-quality-of-life-in-women-at-risk-for-gestational-diabetes
#6
Elina Engberg, Heikki O Tikkanen, Anne Koponen, Harriet Hägglund, Katriina Kukkonen-Harjula, Aila Tiitinen, Juha E Peltonen, Maritta Pöyhönen-Alho
This study examined the associations of cardiorespiratory fitness (CRF) and leisure-time physical activity (LTPA) with health-related quality of life (HRQoL) in women at risk for gestational diabetes mellitus (GDM). The participants were 39 women planning pregnancy with a history of GDM and/or BMI > 29 kg·m(-2) . We assessed CRF by measuring maximal oxygen consumption (O2max ) during incremental cycle ergometer exercise until voluntary fatigue. LTPA was self-reported, and HRQoL assessed with the SF-36 Health Survey (SF-36)...
April 17, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28414015/effects-of-depression-metabolic-syndrome-and-cardiorespiratory-fitness-on-mortality-results-from-the-cooper-center-longitudinal-study
#7
C D Rethorst, D Leonard, C E Barlow, B L Willis, M H Trivedi, L F DeFina
BACKGROUND: Depression and metabolic syndrome (MetS) are frequently comorbid disorders that are independently associated with premature mortality. Conversely, cardiorespiratory fitness (CRF) is associated with reduced mortality risk. These factors may interact to impact mortality; however, their effects have not been assessed concurrently. This analysis assessed the mortality risk of comorbid depression/MetS and the effect of CRF on mortality in those with depression/MetS. METHODS: Prospective study of 47 702 adults in the Cooper Center Longitudinal Study...
April 17, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28412186/cardiorespiratory-fitness-physical-activity-and-cancer-mortality-in-men
#8
Baruch Vainshelboim, Jan Müller, Ricardo M Lima, Kevin T Nead, Cariad Chester, Khin Chan, Peter Kokkinos, Jonathan Myers
The preventive role of cardiorespiratory fitness (CRF) and physical activity (PA) in cancer mortality is not well-established. This study sought to evaluate the association between CRF, PA and cancer mortality in men. Maximal exercise testing was performed at the VA Palo Alto Health Care System in 5876 male veterans (60.5±11years) free from malignancy at baseline who were followed for mean of 9.9 (range 0.11 to 26.8) years. PA status was assessed in a sub-group of 4034 participants. Relative risks and population attributable risks (PAR%) for cancer-related mortality were determined...
April 13, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28408246/renal-protective-effect-and-action-mechanism-of-huangkui-capsule-and-its-main-five-flavonoids
#9
Hong-Die Cai, Shu-Lan Su, Da-Wei Qian, Sheng Guo, Wei-Wei Tao, Xu Dong Cong, Renmao Tang, Jin-Ao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: The flower of Abelmoschus manihot (Linn.) Medicus (A. manihot), as a traditional Chinese Herbal medicine, was used widely in China with efficacy of inducing diuresis for treating strangurtia, and subdhing swelling and detoxicating. It has been reported that Huangkui capsule, prepared by the extract of the flower of A. manihot, can reduce the content of urinary protein, serum creatinine and serum urea nitrogen in nephropathy rats and processes renoprotective activity, while the action mechanism need to illuminate deeply...
April 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28407904/characterization-and-functionalities-study-of-hemicellulose-and-cellulose-components-isolated-from-sorghum-bran-bagasse-and-biomass
#10
Shuang Qiu, Madhav P Yadav, Lijun Yin
This study was undertaken to isolate and characterize three carbohydrate-rich fractions: Hemicellulose A (Hemi. A), Hemicellulose B (Hemi. B) and cellulose-rich residue (CRF) from sorghum bran (SBR), sorghum bagasse (SBA) and sorghum biomass (SBI). The monosaccharide composition of the Hemi. A and Hemi. B fractions was determined, indicating that SBR has a highly branched structure. The analysis of insoluble dietary fiber (IDF), soluble dietary fiber (SDF) and total dietary fiber (TDF) showed that TDF and IDF contents in original sorghum materials were in the following order: SBA˃SBI˃SBR...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28407353/binding-co2-by-a-cr8-metallacrown
#11
Iñigo J Vitórica-Yrezábal, Daniel Florin Sava, Grigore A Timco, Martyn S Brown, Mathew Savage, Harry G W Godfrey, Florian Moreau, Martin Schröder, Flor Siperstein, Lee Brammer, Sihai Yang, Martin P Attfield, Joseph J W McDouall, Richard E P Winpenny
The {Cr8 } metallacrown [CrF(O2 C(t) Bu)2 ]8 , containing a F-lined internal cavity, shows high selectivity for CO2 over N2 . DFT calculations and absorption studies support the multiple binding of F-groups to the C-center of CO2 (C⋅⋅⋅F 3.190(9)-3.389(9) Å), as confirmed by single-crystal X-ray diffraction.
April 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28406669/methodology-of-performance-scoring-in-the-d2-sustained-attention-test-cumulative-reliability-functions-and-practical-guidelines
#12
Michael B Steinborn, Robert Langner, Hagen C Flehmig, Lynn Huestegge
We provide a psychometric analysis of commonly used performance indices of the d2 sustained-attention test, and give methodical guidelines and recommendations, based on this research. We examined experimental effects of repeated testing on performance speed and accuracy (omission and commission errors), and further evaluated aspects of test reliability by means of cumulative reliability function (CRF) analysis. These aspects were also examined for a number of alternative (yet commonly used) scoring techniques and valuation methods...
April 13, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28399980/effects-of-exercise-on-cancer-related-fatigue-and-quality-of-life-in-prostate-cancer-patients-undergoing-androgen-deprivation-therapy-a-meta-analysis-of-randomized-clinical-trials
#13
Yang Bo, Wang Jiansheng
Objective To gain insight on how exercise affects the outcomes of prostate cancer patients treated with androgen deprivation therapy, specifically cancer-related fatigue (CRF) and quality of life (QoL).Methods Systematic searches for randomized clinical trials (RCTs) evaluating the effects of exercise on CRF and QoL of prostate cancer patients receiving androgen deprivation therapy were carried out to identify the eligible studies from EMBASE, PubMed and Cochrane library. Related data were extracted from eligible studies and then subjected to Reviewer Manage 5...
April 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28399841/building-a-research-registry-for-studying-birth-complications-and-outcomes-in-six-palestinian-governmental-hospitals
#14
Sahar Hassan, Ase Vikanes, Katariina Laine, Khaled Zimmo, Mohammad Zimmo, Espen Bjertness, Erik Fosse
BACKGROUND: Electronic-health (e-health) provides opportunities for quality improvement of healthcare, but implementation in low and middle income countries is still limited. Our aim was to describe the implementation of a registration (case record form; CRF) for obstetric interventions and childbirth events using e-health in a prospective birth cohort study in Palestine. We also report the completeness and the reliability of the data. METHODS: Data on maternal and fetal health was collected prospectively for all women admitted to give birth during the period from 1st March 2015 to 31st December 2015 in three governmental hospitals in Gaza and three in the West Bank...
April 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28396043/body-mass-index-and-cardiorespiratory-fitness-in-mid-life-and-risk-of-heart-failure%C3%A2-hospitalization-in-older-age-findings-from-the-cooper-center-longitudinal-study
#15
Ambarish Pandey, William K Cornwell, Benjamin Willis, Ian J Neeland, Ang Gao, David Leonard, Laura DeFina, Jarett D Berry
OBJECTIVES: This study evaluated the contributions of obesity and changes in body mass index (BMI) in mid-life to long-term heart failure (HF) risk independent of cardiorespiratory fitness (CRF) levels. BACKGROUND: Obesity and low CRF are well-established risk factors for HF. However, given the inverse association between CRF and obesity, the independent contributions of BMI toward HF risk are not fully understood. METHODS: We included 19,485 participants from the Cooper Center Longitudinal Study who survived to receive Medicare coverage, from 1999 to 2009...
March 30, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28392007/exercise-sleep-and-cancer-related-fatigue-are-they-related
#16
REVIEW
Mary E Medysky, John Temesi, Susan Nicole Culos-Reed, Guillaume Y Millet
Cancer-related fatigue (CRF) is a commonly reported and debilitating side effect of cancer and/or cancer treatment. Sleep disorders are also highly reported in the cancer population; however it is unknown if sleep is associated with fatigue. In the general population, exercise has been shown to improve sleep, however in the cancer population this idea is under investigation. The primary purposes of this review were to: (i) review the prevalence and causes of sleep disorders in cancer patients and survivors, (ii) examine the relationship between sleep and CRF and (iii) review the impact of exercise interventions on sleep in cancer patients and survivors...
April 5, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28391877/influence-of-sedentary-behavior-physical-activity-and-cardiorespiratory-fitness-on-the-atherogenic-index-of-plasma
#17
Meghan K Edwards, Michael J Blaha, Paul D Loprinzi
BACKGROUND: Atherogenic index of plasma (AIP), calculated as LOG10 (triglycerides/high-density lipoprotein-cholesterol), may have greater utility over other metrics in predicting risk for cardiovascular disease (CVD). Previous work demonstrates the associations of physical activity (PA), sedentary behavior, and cardiorespiratory fitness (CRF) with triglycerides high-density lipoprotein (HDL-C) and CVD. OBJECTIVE: Limited research has examined these parameters and their potential additive associations with AIP, which was the purpose of this study...
January 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28390681/relation-between-estimated-cardiorespiratory-fitness-and-atrial-fibrillation-from-the-reasons-for-geographic-and-racial-differences-in-stroke-study
#18
Abhishek Bose, Wesley T O'Neal, Aleena Bennett, Suzanne E Judd, Waqas T Qureshi, Xuemei Sui, Virginia J Howard, George Howard, Elsayed Z Soliman
Estimated cardiorespiratory fitness (e-CRF) based on readily available clinical and self-reported data is a promising alternative to the costly traditional assessment of CRF using exercise equipment, but its role as a predictor for incident atrial fibrillation (AF) is unclear. This study included 10,126 participants (54.5% women, 35% African-American, mean age 63.2 years) from the Reasons for Geographic and Racial Differences in Stroke study who were free of AF at baseline. Baseline (2003 to 2007) e-CRF was determined using a previously validated nonexercise algorithm...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28386756/effects-of-a-physical-activity-program-on-cardiorespiratory-fitness-and-pulmonary-function-in-obese-women-after-bariatric-surgery-a-pilot-study
#19
Tatiana Onofre, Renata Carlos, Nicole Oliver, Amanda Felismino, Davi Fialho, Renata Corte, Eliane Pereira da Silva, Eudes Godoy, Selma Bruno
BACKGROUND: In severely obese individuals, reducing body weight induced by bariatric surgery is able to promote a reduction in comorbidities and improve respiratory symptoms. However, cardiorespiratory fitness (CRF) reflected by peak oxygen uptake (VO2peak) may not improve in individuals who remain sedentary post-surgery. The objective of this study was to evaluate the effects of a physical training program on CRF and pulmonary function in obese women after bariatric surgery, and to compare them to a control group...
April 7, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28378429/impact-of-lifestyle-behavior-change-on-glycemic-control-in-youth-with-type-2-diabetes
#20
Andrea Kriska, Laure El Ghormli, Kenneth C Copeland, Janine Higgins, Carolyn E Ievers-Landis, Lorraine E Levitt Katz, Paula M Trief, Aimee D Wauters, Patrice M Yasuda, Linda M Delahanty
BACKGROUND: Little is known about the feasibility and impact of lifestyle intervention, determined by change in diet and cardiovascular fitness (CRF), on glycemic control in youth who are overweight with type 2 diabetes. This was examined in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial cohort from across 15 US centers. SUBJECTS: TODAY enrolled 699 youth aged 10 to 17 years with type 2 diabetes <2 years and body mass index ≥85th percentile at baseline...
April 4, 2017: Pediatric Diabetes
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