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https://www.readbyqxmd.com/read/28641152/urea-induced-ros-accelerate-senescence-in-endothelial-progenitor-cells
#1
Maria D'Apolito, Anna Laura Colia, Maria Lasalvia, Vito Capozzi, Maria Pia Falcone, Massimo Pettoello-Mantovani, Michael Brownlee, Angela Bruna Maffione, Ida Giardino
BACKGROUND AND AIMS: The pathogenic events responsible for the reduction of endothelial progenitor cell (EPC) number and function seen in patients with chronic renal failure (CRF) are poorly understood. Here we investigate the hypothesis that increased concentrations of urea associated with CRF increase ROS production directly in EPCs, causing abnormalities associated with coronary artery disease risk. METHODS: Human EPCs were isolated from peripheral blood mononuclear cells of healthy donors and cultured in the presence or absence of 20 mmol/L urea...
June 15, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28639432/muscle-mass-as-a-target-to-reduce-fatigue-in-patients-with-advanced-cancer
#2
Elisabeth C W Neefjes, Renske M van den Hurk, Susanne Blauwhoff-Buskermolen, Maurice J D L van der Vorst, Annemarie Becker-Commissaris, Marian A E de van der Schueren, Laurien M Buffart, Henk M W Verheul
BACKGROUND: Cancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF. METHODS: A total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorectal, breast, or prostate cancer were studied. The skeletal muscle index (SMI) was calculated as the patient's muscle mass on level L3 or T4 of a computed tomography scan, adjusted for height...
June 21, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28638222/corticotropin-releasing-factor-stimulates-colonic-motility-via-muscarinic-receptors-in-the-rat
#3
Kyung-Jo Kim, Ki Bae Kim, Soon Man Yoon, Joung-Ho Han, Hee Bok Chae, Seon Mee Park, Sei Jin Youn
AIM: To measure exogenous corticotropin-releasing factor (CRF)-induced motility of the isolated rat colon and to demonstrate the effect of pharmacologic inhibition on CRF-induced motility. METHODS: The isolated vascularly-perfused rat colon was used. Luminal pressure was monitored via microtip catheter pressure transducers in the proximal and distal colon. At first, exogenous CRF was administered in a stepwise manner and the concentration of CRF yielding maximal colonic motility was selected...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28636808/diversity-and-abundance-of-human-pathogenic-fungi-associated-with-pigeon-feces-in-urban-environments
#4
Won Dong Lee, Jonathan J Fong, John A Eimes, Young Woon Lim
Pathogenic fungi are a growing health concern worldwide, particularly in large, densely populated cities. The dramatic upsurge of pigeon populations in cities has been implicated in the increased incidence of invasive fungal infections. In the current study, we used a culture-independent, high-throughput sequencing approach to describe the diversity of clinically relevant fungi (CRF) associated with pigeon feces and map the relative abundance of CRF across Seoul, Korea. In addition, we tested whether certain geographical, sociological, and meteorological factors were significantly associated with the diversity and relative abundance of CRF...
June 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28633075/elective-unilateral-nodal-irradiation-in-head-and-neck-squamous-cell-carcinoma-a-paradigm-shift
#5
A Al-Mamgani, M Verheij, M W M van den Brekel
There is a long-standing convention to irradiate the great majority of head and neck squamous cell carcinoma (HNSCC) electively to both sides of the neck, to reduce the theoretically increased risk of contralateral regional failure (cRF). With the currently available diagnostic imaging techniques this treatment paradigm means, in our opinion, an overtreatment in considerable proportion of these patients. From all the published studies (n = 11, with 1116 patients treated in total), the incidence of cRF in patients with oropharyngeal cancer treated to one side of the neck is 2...
June 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28631900/-experimental-development-and-rationale-for-a-renal-decellularization-protocol-with-subsequent-comprehensive-assessment-of-the-biological-scaffold
#6
P V Glybochko, S N Alekseenko, E A Gubareva, E V Kuevda, A A Basov, A S Sotnichenko, S S Dzhimak, I S Gumenyuk, I Kh Egiev, V N Chechelyan, R Z Nakokhov, O M Lyasota, Yu V Teterin
Chronic renal failure (CRF) is one of the most challenging problems of contemporary medicine. Patients with chronic renal failure usually need renal replacement therapy as either hemodialysis, peritoneal dialysis or a kidney transplant. The latter is the most promising option for end-stage kidney disease. However, the shortage of donor organs, the complexity of their delivery, the difficulty in finding an immunologically compatible donor and the need for lifelong immunosuppression triggered advances in modern tissue engineering...
June 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28628667/characterization-of-hiv-1-crf90_bf1-and-putative-novel-crfs_bf1-in-central-west-north-and-northeast-brazilian-regions
#7
Mônica Nogueira da Guarda Reis, Gonzalo Bello, Monick Lindenmeyer Guimarães, Mariane Martins Araújo Stefani
The Brazilian AIDS epidemic has been characterized by an increasing rate of BF1 recombinants and so far eight circulating recombinant forms/CRFs_BF1 have been described countrywide. In this study, pol sequences (protease/PR, reverse transcriptase/RT) of 87 BF1 mosaic isolates identified among 828 patients living in six Brazilian States from three geographic regions (Central West, North, Northeast) were analyzed. Phylogenetic and bootscan analyses were performed to investigate the evolutionary relationship and mosaic structure of BF1 isolates...
2017: PloS One
https://www.readbyqxmd.com/read/28626817/comparison-of-current-tonometry-techniques-in-measurement-of-intraocular-pressure
#8
Behrooz Kouchaki, Hassan Hashemi, Abbasali Yekta, Mehdi Khabazkhoob
PURPOSE: To compare four tonometry techniques: Goldmann applanation tonometer (GAT), Dynamic contour tonometer (DCT), Non-contact tonometer (NCT), and Ocular Response Analyzer (ORA) in the measurement of intraocular pressure (IOP) and the impact of some corneal biomechanical factors on their performance. METHODS: In this cross-sectional study, volunteers with normal ophthalmic examination and no history of eye surgery (except for uncomplicated cataract surgery) or trauma were selected...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28626602/association-between-corneal-biomechanical-properties-with-ocular-response-analyzer-and-also-corvisst-tonometry-and-glaucomatous-visual-field-severity
#9
Kazunori Hirasawa, Masato Matsuura, Hiroshi Murata, Shunsuke Nakakura, Yoshitaka Nakao, Yoshiaki Kiuchi, Ryo Asaoka
PURPOSE: To investigate the association between corneal biomechanical properties measured with the Ocular Response Analyzer (ORA) and also CorvisST (CST) tonometry, and glaucomatous visual field (VF) severity. METHODS: One hundred forty-six eyes of 91 patients with primary open-angle glaucoma who performed Humphrey Field Analyzer 30-2 or 24-2 SITA-Standard, ORA, and CST within 180 days were included in this multicentral, observational cross-sectional study. The association between ORA parameters (corneal hysteresis [CH] and corneal resistant factor [CRF]), CST parameters (A1 and A2 time, A1 and A2 length, A1 and A2 velocity, A1 and A2 deformation amplitude, highest deformation amplitude, highest concavity time, peak distance, and radius), and other basic parameters (age, intraocular pressure with Goldmann applanation tonometry, central corneal thickness, and axial length) against mean total deviation (mTD) were analyzed using a linear mixed-model and model selection with corrected Akaike Information Criterion (AICc)...
June 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28625819/outcomes-of-relocation-of-basilic-vein-in-brachiobasilic-fistulas-in-chronic-renal-failure
#10
Farzad Kakaei, Ahad Hasankhani, Mir-Salim Seyyed-Sadeghi, Peyman Virani, Tooraj Asvadi, Sina Zarrintan
BACKGROUND: In patients without or with injured cephalic vein, using the basilic vein for creating arteriovenous fistula (AVF) is the best way for hemodialysis. In order to create AVF, the basilic vein should be superficialized and lateralized. This study sought to examine outcome of relocation of basilic vein in brachiobasilic fistulas in patients with chronic renal failure (CRF). METHODS: We evaluated the outcome of creation of brachiobasilic fistula with transposition of basilic vein in 27 patients (14 males and 13 females with mean age of 60...
June 15, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28624677/cardiorespiratory-benefits-of-group-exercise-among-adults-with-serious-mental-illness
#11
Gerald J Jerome, Deborah Rohm Young, Arlene T Dalcin, Nae-Yuh Wang, Joseph Gennusa, Stacy Goldsholl, Lawrence J Appel, Gail L Daumit
This study examined cardiorespiratory fitness (CRF) among adults with serious mental illness (SMI) participating in group exercise classes. Overweight and obese adults with SMI were randomized to either a control condition or a weight management condition with group exercise classes (n = 222). Submaximal bicycle ergometry was used to assess CRF at baseline, 6 and 18 months. Those with ≥ 66% participation in the exercise classes had a lower heart rate response at 6 and 18 month follow-up. Participation in group exercise classes was associated with improved short and long term cardiovascular fitness among adults with SMI...
June 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28622345/the-infection-staging-and-profile-of-genotypic-distribution-and-drug-resistance-mutation-among-the-human-immunodeficiency-virus-1-infected-blood-donors-from-five-chinese-blood-centers-2012-2014
#12
Peibin Zeng, Yu Liu, Miao He, Jingxing Wang, Sheila Keating, Wei Mao, Mei Huang, Hongli Ma, Weilan He, Xinhong Bi, Dan Liao, Michael Busch, Paul Ness, Jing Liu, Hua Shan
The increasing complexity and diversity of the human immunodeficiency virus-1 (HIV-1) infections challenge the disease control and anti-retrovirus treatment in China. The infection stages and molecular characteristics of HIV-1 from infected Chinese blood donors were examined to shed light on the HIV genotype distribution and the status of drug resistance mutations (DRMs) in the changing HIV epidemic in China. Western blot (WB) confirmed HIV-1 positive plasma samples were collected from blood donors at five Chinese blood centers from April 16, 2012, through June 30, 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28614436/social-instigation-and-repeated-aggressive-confrontations-in-male-swiss-mice-analysis-of-plasma-corticosterone-crf-and-bdnf-levels-in-limbic-brain-areas
#13
Paula Madeira Fortes, Lucas Albrechet-Souza, Mailton Vasconcelos, Bruna Maria Ascoli, Ana Paula Menegolla, Rosa Maria M de Almeida
Introduction: Agonistic behaviors help to ensure survival, provide advantage in competition, and communicate social status. The resident-intruder paradigm, an animal model based on male intraspecific confrontations, can be an ethologically relevant tool to investigate the neurobiology of aggressive behavior. Objectives: To examine behavioral and neurobiological mechanisms of aggressive behavior in male Swiss mice exposed to repeated confrontations in the resident intruder paradigm...
June 12, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28612996/crf1-and-crf2-receptors-in-the-bed-nucleus-of-stria-terminalis-differently-modulate-the-baroreflex-function-in-unanesthetized-rats
#14
Leandro A Oliveira, Jeferson Almeida, Lucas Gomes-de-Souza, Ricardo Benini, Carlos C Crestani
The baroreflex is an important blood pressure regulating mechanism. The bed nucleus of stria terminalis (BNST) modulates the baroreflex function. However, the local BNST neurochemical mechanisms involved in control of baroreflex responses are not completely understood. Therefore, in the present study we investigated the involvement of corticotropin-releasing factor (CRF) receptors within the BNST in baroreflex control of heart rate in unanesthetized rats. For this, we evaluated effects of bilateral microinjection into the BNST of either the selective CRF1 receptor antagonist CP376395 (5nmol/100nL) or the selective CRF2 receptor antagonist antisauvagine-30 (5nmol/100nL) in bradycardiac response evoked by blood pressure increases caused by intravenous infusion of phenylephrine as well as tachycardiac response to blood pressure decrease caused by intravenous infusion of sodium nitroprusside...
June 14, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28611665/toll-like-receptor-4-in-paraventricular-nucleus-mediates-visceral-hypersensitivity-induced-by-maternal-separation
#15
Hui-Li Tang, Gongliang Zhang, Ning-Ning Ji, Lei Du, Bin-Bin Chen, Rong Hua, Yong-Mei Zhang
Neonatal maternal separation (MS) is a major early life stress that increases the risk of emotional disorders, visceral pain perception and other brain dysfunction. Elevation of toll-like receptor 4 (TLR4) signaling in the paraventricular nucleus (PVN) precipitates early life colorectal distension (CRD)-induced visceral hypersensitivity and pain in adulthood. The present study aimed to investigate the role of TLR4 signaling in the pathogenesis of postnatal MS-induced visceral hypersensitivity and pain during adulthood...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28606473/cardiorespiratory-fitness-and-exercise-training-in-african-americans
#16
REVIEW
Damon L Swift, Neil M Johannsen, Conrad P Earnest, Robert L Newton, Joshua E McGee, Timothy S Church
African Americans (AAs) have a higher risk for cardiovascular disease (CVD) compared to their Caucasian American ( CA) counterparts, which represents a major health disparity. Low cardiorespiratory fitness (CRF) is a well-established independent risk factor for all-cause and CVD mortality, which has been shown across many epidemiological and clinical trials to be lower in AAs compared to CAs. While much attention has been given to traditional health disparity risk factors (e.g. blood pressure, obesity, insulin resistance), the impact of racial differences in CRF on CVD mortality has not been widely considered...
June 10, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28598909/cardiorespiratory-reference-data-in-older-adults-the-generation-100-study
#17
Dorthe Stensvold, Silvana Bucher Sandbakk, Hallgeir Viken, Nina Zisko, Line Skarsem Reitlo, Javaid Nauman, Svein Erik Gaustad, Erlend Hassel, Marcel Moufack, Eivind Brønstad, Nils Petter Aspvik, Vegard Malmo, Sigurd Loe Steinshamn, Asbjørn Støylen, Sigmund Alfred Anderssen, Jorunn L Helbostad, Øivind Rognmo, Ulrik Wisløff
PURPOSE: Cardiorespiratory fitness (CRF) is regarded a clinical vital sign, and accurate reference values for all age groups are essential. Little data exist on CRF and cardiorespiratory function in older adults. The aim of this study was to provide normative values for CRF and cardiorespiratory function in older adults, including people with history of cardiovascular diseases. METHODS: In total, 1537 (769 women) participants aged 70-77 underwent clinical examinations and cardiopulmonary exercise tests...
June 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28598050/consensus-document-on-home-nebulization-for-maintenance-treatment-of-obstructive-airway-diseases-a-joint-initiative-by-the-national-allergy-asthma-bronchitis-institute-naabi-and-chest-research-foundation-crf
#18
Aloke G Ghoshal, Sundeep Salvi, Raja Dhar, Randeep Guleria, Ashok Mahashur, Anshuman Mukhopadhyay, Rmpl Ramanathan
Recent years have seen an increase in the use of nebulizers for delivering maintenance therapy in obstructive airway diseases (OADs) such as asthma and chronic obstructive pulmonary disease (COPD). The probable factors associated with this increase at home are: convenience of drug delivery, technological advances making the nebulizer equipment more efficient and portable, increase in the prevalence of OADs and the ageing population which may impact the optimal use of handheld inhalers such as pressurized metered dose inhalers (pMDIs) and dry powder inhalers (DPIs)...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28594657/fitness-moderates-glycemic-responses-to-sitting-and-light-activity-breaks
#19
Matthew McCarthy, Charlotte L Edwardson, Melanie J Davies, Joseph Henson, Danielle H Bodicoat, Kamlesh Khunti, David W Dunstan, James A King, Thomas Yates
PURPOSE: This study aimed to experimentally determine whether cardio-respiratory fitness (CRF) modifies postprandial glycemia during prolonged sitting and investigated the potentially blunting influence this may have upon the benefits of interrupting postprandial sitting time with light activity breaks. METHODS: Thirty-four adults (18female; 16male; mean ± SD age: 40 ± 9years, BMI: 24.5 ± 3kg/m) undertook two 7·5hour experimental conditions in a randomized order: 1) Prolonged sitting; 2) Sitting interspersed with 5min light walking bouts every 30min...
June 8, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28593120/addition-of-estimated-cardiorespiratory-fitness-to-the-clinical-assessment-of-10-year-coronary-heart-disease-risk-in-asymptomatic-men
#20
Jennifer C Gander, Xuemei Sui, James R Hébert, Carl J Lavie, Linda J Hazlett, Bo Cai, Steven N Blair
The Framingham Risk Score (FRS) was developed to quantify a patient's coronary heart disease (CHD) risk. Non-exercise estimated CRF (e-CRF) may provide a clinically practical method for describing cardiorespiratory fitness. We computed e-CRF and tested its association with the FRS and CHD. Male participants (n = 29,854) in the Aerobics Center Longitudinal Study (ACLS) who completed a baseline examination between 1979-2002 were followed for 12 years to determine incident CHD defined by self-report of myocardial infarction, revascularization, or CHD mortality...
September 2017: Preventive Medicine Reports
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