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https://www.readbyqxmd.com/read/28916717/nlrps-the-subcortical-maternal-complex-and-genomic-imprinting
#1
David Monk, Marta Sanchez-Delgado, Rosemary Fisher
Before activation of the embryonic genome, the oocyte provides many of the RNAs and proteins required for the epigenetic reprogramming and the transition to a totipotent state. Targeted disruption of a subset of oocyte-derived transcripts in mice results in early embryonic lethality and cleavage stage embryonic arrest as highlighted by the members of the Subcortical Maternal Complex (SCMC). Maternal-effect recessive mutations of NLRP7, KHDC3L and NLRP5 in humans are associated with variable reproductive outcomes, biparental hydatidiform moles (BiHM) and widespread multi-locus imprinting disturbances...
September 15, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28916147/microbial-associates-of-the-southern-mole-cricket-scapteriscus-borellii-are-highly-pathogenic
#2
Sudarshan K Aryal, Derreck Carter-House, Jason E Stajich, Adler R Dillman
We report the isolation and identification of seven bacterial strains and one fungal strain from dead and diseased Scapteriscus borellii mole crickets collected from a golf course in southern California. Using 16S and 18S rRNA gene sequence analysis we identified the microbes as Serratia marcescens (red), S. marcescens (white), S. marcescens (purple), Achromobacter xylosoxidans, Chryseobacterium sp., Ochrobactrum anthropi, Tsukamurella tryosinosolvens, and Beauveria bassiana. We performed a dose response curve for each of these cricket-associated microbial strains (except T...
September 12, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28914306/enhanced-intermediate-temperature-co2-splitting-using-nonstoichiometric-ceria-and-ceria-zirconia
#3
Zhenlong Zhao, Mruthunjaya Uddi, Nikolai Tsvetkov, Bilge Yildiz, Ahmed F Ghoniem
CO2 splitting via thermo-chemical or reactive redox has emerged as a novel and promising carbon-neutral energy solution. Its performance depends critically on the properties of the oxygen carriers (OC). Ceria is recognized as one of the most promising OC candidates, because of its fast chemistry, high ionic diffusivity, and large oxygen storage capacity. The fundamental surface ion-incorporation pathways, along with the role of surface defects and the adsorbates remain largely unknown. This study presents a detailed kinetics study of CO2 splitting using CeO2 and Ce0...
September 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28905723/breeding-and-rearing-naked-mole-rats-heterocephalus-glaber-under-laboratory-conditions
#4
Chenlin Yu, Shiyong Wang, Guoshi Yang, Shanmin Zhao, Lifang Lin, Wenjing Yang, Qiu Tang, Wei Sun, Shufang Cui
The unique biologic characteristics of naked mole-rats (NMR, Heterocephalus glaber) include longevity, cancer resistance, hypoxia tolerance, and pain insensitivity, making NMR an attractive model for biomedical research on aging, cancer, and neurobiology. However, breeding and rearing NMR in captivity is challenging. Here, we report a method for breeding NMR by using a closed-colony mating system. We selected sexually mature male and female NMR from different natal colonies and mated them 1:1. The 5 original colonies had an annual parity of 3...
January 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28902461/behavioral-responses-of-pest-mole-crickets-neoscapteriscus-spp-orthoptera-gryllotalpidae-to-selected-insecticides
#5
Olga S Kostromytska, Michael E Scharf, Eileen A Buss
BACKGROUND: Mole crickets (Neoscapteriscus spp.) consume turfgrasses and pasture grasses and uproot plants by their tunneling, which decreases turf aesthetics and decreases forage quantity and quality. Insecticides are frequently used to prevent damage. In typical field trials, damage symptoms, not percent of mortality or achieved level of control, are used to assess treatment efficacy. Here however, we evaluated the direct effect of key insecticides on Neoscapteriscus mole cricket behavior...
September 13, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28901950/detecting-drug-target-binding-in-cells-using-fluorescence-activated-cell-sorting-coupled-with-mass-spectrometry-analysis
#6
Kris Wilson, Scott P Webster, John Peter Iredale, Xiaozhong Zheng, Natalie Z M Homer, Nhan Pham, Manfred Auer, Damian James Mole
The assessment of drug-target engagement for determining the efficacy of a compound inside cells remains challenging, particularly for difficult target proteins. Existing techniques are more suited to soluble protein targets. Difficult target proteins include those with challenging in vitro solubility, stability or purification properties that preclude target isolation. Here, we report a novel technique that measures intracellular compound-target complex formation, as well as cellular permeability, specificity and cytotoxicity - the Toxicity-Affinity-Permeability-Selectivity (TAPS) technique...
September 13, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28899975/antagonism-of-eg-vegf-receptors-as-targeted-therapy-for-choriocarcinoma-progression-in-vitro-and-in-vivo
#7
Wael Traboulsi, Frederic Sergent, Houssine Boufettal, Sophie Brouillet, Rima Slim, Pascale Hoffmann, Mohammed Benlahfid, Qun Yong Zhou, Giafranco Balboni, Valentina Onnis, Pierre-Adrien Bolze, Aude Salomon, Philippe Sauthier, François Mallet, Touria Aboussaouira, Jean-Jacques Feige, Mohamed Benharouga, Nadia Alfaidy
PURPOSE: Choriocarcinoma (CC) is the most malignant gestational trophoblastic disease that often develops from complete hydatidiform moles (CHM). Neither the mechanism of CC development nor its progression is yet characterized. We have recently identified EG-VEGF as a novel key placental growth factor that controls trophoblast proliferation and invasion. EG-VEGF acts via two receptors PROKR1 and PROKR2. Here, we demonstrate that EG-VEGF receptors can be targeted for CC therapy. EXPERIMENTAL DESIGN: Three approaches were used, i) a clinical investigation comparing circulating EG-VEGF in Control (n=20) and in distinctive CHM (n=38) and CC (n=9) cohorts, ii) an in vitro study investigating EG-VEGF effects on the CC cell line JEG3, and iii) an in vivo study including the development of a novel CC mouse model, through a direct injection of JEG3-luciferase into the placenta of gravid SCID-mice...
September 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28899002/the-unexpected-intelligence-what-is-the-naked-mole-rat-s-secret-to-surviving-oxygen-deprivation
#8
Senka Ljubojevic-Holzer
No abstract text is available yet for this article.
August 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28892384/kinetics-of-trifluoromethane-clathrate-hydrate-formation-from-chf3-gas-and-ice-particles
#9
Jaruwan Amtawong, Suvrajit Sengupta, Michael T Nguyen, Nicole C Carrejo, Jin Guo, Everly B Fleischer, Rachel W Martin, Kenneth C Janda
We report the formation kinetics of trifluoromethane clathrate hydrate (CH) from <75 μm diameter ice particles and CHF3 gas. As previously observed for difluoromethane and propane hydrate formation, the initial stages of the reaction exhibit a strong negative correlation of the reaction rate with temperature, consistent with a negative activation energy of formation. The values obtained for trifluoromethane, ~ -6 kJ/mol (H2O), are similar to those for difluoromethane, even though the two molecules have different intermolecular interactions and sizes...
September 11, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28892119/prophylactic-chemotherapy-for-hydatidiform-mole-to-prevent-gestational-trophoblastic-neoplasia
#10
REVIEW
Qiuyi Wang, Jing Fu, Lina Hu, Fang Fang, Lingxia Xie, Hengxi Chen, Fan He, Taixiang Wu, Theresa A Lawrie
BACKGROUND: This is an update of the original Cochrane Review published in Cochrane Library, Issue 10, 2012.Hydatidiform mole (HM), also called a molar pregnancy, is characterised by an overgrowth of foetal chorionic tissue within the uterus. HMs may be partial (PM) or complete (CM) depending on their gross appearance, histopathology and karyotype. PMs usually have a triploid karyotype, derived from maternal and paternal origins, whereas CMs are diploid and have paternal origins only...
September 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28891905/reviews-of-the-future-of-basic-science-in-academic-surgery-identifying-barriers-to-success-for-surgeon-scientists-by-keswani-s-moles-cm-morowitz-m-zeh-h-kuo-js-levine-mh-cheng-ls-hackam-dj-ahuja-n-goldestein-am-basic-science-committee-of-the-society-of-university
#11
https://www.readbyqxmd.com/read/28890188/harnessing-the-respiration-machinery-for-high-yield-production-of-chemicals-in-metabolically-engineered-lactococcus-lactis
#12
Jianming Liu, Zhihao Wang, Vijayalakshmi Kandasamy, Sang Yup Lee, Christian Solem, Peter Ruhdal Jensen
When modifying the metabolism of living organisms with the aim of achieving biosynthesis of useful compounds, it is essential to ensure that it is possible to achieve overall redox balance. We propose a generalized strategy for this, based on fine-tuning of respiration. The strategy was applied on metabolically engineered Lactococcus lactis strains to optimize the production of acetoin and (R,R)-2,3-butanediol (R-BDO). In the absence of an external electron acceptor, a surplus of two NADH per acetoin molecule is produced...
September 8, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28886799/mole-mapping-for-management-of-pigmented-skin-lesions
#13
REVIEW
Juliana Berk-Krauss, David Polsky, Jennifer A Stein
Identifying new or changing melanocytic lesions, particularly in patients with numerous or atypical nevi, can be challenging. Total-body photography and sequential digital dermoscopy imaging, together known as digital follow-up, are 2 prominent forms of noninvasive imaging technology used in mole mapping that have been found to improve diagnostic accuracy, detect earlier-stage melanomas, and reduce costs. Digital follow-up, in combination with direct-to-consumer applications and teledermatology, is already revolutionizing the ways in which physicians and patients participate in melanoma surveillance and will likely continue to enhance early detection efforts...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28885714/monoclonal-gammopathy-of-undetermined-significance-mgus-as-viewed-by-haematology-healthcare-professionals
#14
Charlene M McShane, Blain Murphy, Kah Heng Lim, Lesley A Anderson
OBJECTIVES: To investigate the words and descriptions used by haematology healthcare professionals (HCPs) to describe monoclonal gammopathy of undetermined significance (MGUS) to their patients. METHODS: A cross-sectional survey of haematology HCPs attending an annual haematology conference was undertaken. Content analysis was applied to the returned qualitative responses. RESULTS: In total, 55 people, many of whom were doctors (n=32; 58.2%) responded...
September 8, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28885629/urea-glass-preparation-of-titanium-niobium-nitrides-and-subsequent-oxidation-to-photoactive-titanium-niobium-oxynitrides
#15
James J Brancho, Aaron D Proctor, Shobhana Panuganti, Bart M Bartlett
Titanium niobium oxynitrides (TiNbON) are an attractive category of potential photocatalysts, but strategies for preparing them remain limited. We adapt the wet chemical "urea glass" method for pure transition metal nitrides to single-phase mixed-metal titanium niobium nitrides for a range of niobium mole fractions. We then oxidize the nitrides by heating in air to prepare titanium niobium oxynitride that absorbs visible light of λ ≤ 550 nm. The materials are characterized by powder X-ray diffraction, scanning electron microscopy, and diffuse reflectance UV-vis spectroscopy...
September 8, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28879469/pancreatic-cancer-screening
#16
REVIEW
Koushik K Das, Dayna Early
PURPOSE OF REVIEW: This review describes the rationale for pancreatic cancer screening, outlines groups that are at elevated risk for pancreatic cancer, and summarizes the relative risk in each setting. We also review the methods available for performing pancreatic cancer screening and the recommended screening intervals. RECENT FINDINGS: Several genetic mutations have been identified that increase the risk for pancreatic cancer. Most are rare, however, and at-risk individuals are most often those with a strong family history of pancreatic cancer (with multiple family members affected) but no identifiable genetic mutation...
September 6, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28878977/how-effective-is-incidental-learning-of-the-shape-of-probability-distributions
#17
Randy Tran, Edward Vul, Harold Pashler
The idea that people learn detailed probabilistic generative models of the environments they interact with is intuitively appealing, and has received support from recent studies of implicit knowledge acquired in daily life. The goal of this study was to see whether people efficiently induce a probability distribution based upon incidental exposure to an unknown generative process. Subjects played a 'whack-a-mole' game in which they attempted to click on objects appearing briefly, one at a time on the screen...
August 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28877059/choriocarcinoma-in-women-analysis-of-a-case-series-with-genotyping
#18
Johanna Savage, Emily Adams, Emanuela Veras, Kathleen M Murphy, Brigitte M Ronnett
Choriocarcinoma is an uncommon malignant neoplasm, which can be either gestational or nongestational in origin. Distinction of these subtypes has prognostic and therapeutic implications. Twenty-two tumors were genotyped using polymerase chain reaction amplification of 15 short tandem repeat loci and the amelogenin locus (XY determination). DNA patterns from tumor and maternal tissue, as well as villous tissue from any available prior or concurrent gestation, were compared, to determine gestational versus nongestational nature (containing vs...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28874585/active-molecular-iodine-photochemistry-in-the-arctic
#19
Angela R W Raso, Kyle D Custard, Nathaniel W May, David Tanner, Matt K Newburn, Lawrence Walker, Ronald J Moore, L G Huey, Liz Alexander, Paul B Shepson, Kerri A Pratt
During springtime, the Arctic atmospheric boundary layer undergoes frequent rapid depletions in ozone and gaseous elemental mercury due to reactions with halogen atoms, influencing atmospheric composition and pollutant fate. Although bromine chemistry has been shown to initiate ozone depletion events, and it has long been hypothesized that iodine chemistry may contribute, no previous measurements of molecular iodine (I2) have been reported in the Arctic. Iodine chemistry also contributes to atmospheric new particle formation and therefore cloud properties and radiative forcing...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28873306/mixing-behavior-in-binary-anionic-gemini-surfactant-perfluorinated-fatty-acid-langmuir-monolayers
#20
Jeveria Rehman, David Sowah-Kuma, Amy L Stevens, Wei Bu, Matthew F Paige
The miscibility and film structure of mixed Langmuir monolayer films comprised of an anionic gemini N, N, N', N'dialkyl-N,N'-diacetate ethylenediamine surfactant (Ace(12)-2-Ace(12)) with perfluorotetradecanoic acid (C13F27COOH; PF) has been investigated using a variety of thermodynamic and structural characterization methods. The two film components were found to be miscible in monolayers at the air-water interface over a range of compositions and at all but the lowest surface pressures, with attractive interactions occurring between the two components...
September 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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