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https://www.readbyqxmd.com/read/28267478/multimorbidity-and-the-risk-of-hospitalization-and-death-in-atrial-fibrillation-a-population-based-study
#1
Alanna M Chamberlain, Alvaro Alonso, Bernard J Gersh, Sheila M Manemann, Jill M Killian, Susan A Weston, Margaret Byrne, Véronique L Roger
Patients with atrial fibrillation (AF) have many comorbidities and excess risks of hospitalization and death. Whether the impact of comorbidities on outcomes is greater in AF than the general population is unknown. METHODS: One thousand four hundred thirty patients with AF and community controls matched 1:1 on age and sex were obtained from Olmsted County, Minnesota. Andersen-Gill and Cox regression estimated associations of 19 comorbidities with hospitalization and death, respectively...
March 2017: American Heart Journal
https://www.readbyqxmd.com/read/28267476/cardioversion-and-subsequent-quality-of-life-and-natural-history-of-atrial-fibrillation
#2
Sean D Pokorney, Sunghee Kim, Laine Thomas, Gregg C Fonarow, Peter R Kowey, Bernard J Gersh, Kenneth W Mahaffey, Eric D Peterson, Jonathan P Piccini
Cardioversion is a class I procedure for patients with symptomatic atrial fibrillation (AF) pursuing rhythm control. There are few contemporary reports on quality of life and outcomes after cardioversion. METHODS: Using the nationwide prospective ORBIT-AF registry, cardioversion patients were propensity matched 3:1 to noncardioverted patients and Cox proportional hazards modeling evaluated hospitalization at 1 year in those with and without cardioversion. Cardiovascular outcomes, AF progression, and quality of life were evaluated for the matched cohorts with and without cardioversion...
March 2017: American Heart Journal
https://www.readbyqxmd.com/read/28242636/percutaneous-coronary-intervention-versus-coronary-artery-bypass-grafting-in-patients-with-left-main-and-multivessel-coronary-artery-disease-do-we-have-the-evidence
#3
Bernard J Gersh, Gregg W Stone, Deepak L Bhatt
No abstract text is available yet for this article.
February 28, 2017: Circulation
https://www.readbyqxmd.com/read/28193802/direct-oral-anticoagulants-in-patients-with-atrial-fibrillation-and-valvular-heart-disease-other-than-significant-mitral-stenosis-and-mechanical-valves-a-meta-analysis
#4
Konstantinos C Siontis, Xiaoxi Yao, Bernard J Gersh, Peter A Noseworthy
No abstract text is available yet for this article.
February 14, 2017: Circulation
https://www.readbyqxmd.com/read/28183845/incidence-of-idiopathic-ventricular-arrhythmias-a-population-based-study
#5
Surksha Sirichand, Ammar M Killu, Deepak Padmanabhan, David O Hodge, Alanna M Chamberlain, Peter A Brady, Suraj Kapa, Peter A Noseworthy, Douglas L Packer, Thomas M Munger, Bernard J Gersh, Christopher J McLeod, Win-Kuang Shen, Yong-Mei Cha, Samuel J Asirvatham, Paul A Friedman, Siva K Mulpuru
BACKGROUND: Ventricular tachycardia and premature ventricular complexes (PVCs) most frequently occur in the context of structural heart disease. However, the burden of idiopathic ventricular arrhythmias (IVA) in the general population is unknown. METHODS AND RESULTS: We identified incident cases of IVA between 2005 and 2013 from Olmsted County, Minnesota, using the Rochester Epidemiology Project database. For PVC cohorts, we included those with frequent (defined as ≥100 PVC/24 hours) symptomatic PVCs...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28119130/no-decline-in-the-risk-of-heart-failure-after-incident-atrial-fibrillation-a-community-study-assessing-trends-overall-and-by-ejection-fraction
#6
Alanna M Chamberlain, Bernard J Gersh, Alvaro Alonso, Stephen L Kopecky, Jill M Killian, Susan A Weston, Véronique L Roger
BACKGROUND: Patients with atrial fibrillation (AF) experience an increased risk of heart failure (HF). However, data are lacking on current trends in the risk of HF after AF. OBJECTIVE: The purpose of this study was to describe the temporal trends in HF occurrence after AF in a community cohort of patients with incident AF from 2000 to 2013. METHODS: Cox regression was used to examine the association of year of AF diagnosis with HF and the predictors of developing HF after AF...
January 21, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28109927/quantitative-assessment-of-myocardial-blood-flow-in-cardiac-sarcoidosis-a-potential-next-step-in-the-further-integration-of-fdg-pet-in-imaging-management
#7
EDITORIAL
Panithaya Chareonthaitawee, John P Bois, Bernard J Gersh
No abstract text is available yet for this article.
February 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28067518/mobile-monomers-and-dimers-in-precipitation-kinetics-a-microscopic-approach
#8
Gersh O Berim, Lana I Brim, Eli Ruckenstein
A microscopic theory of precipitation kinetics in solution developed previously by Ruckenstein and co-workers [ Dadyburjor , D. B. ; Ruckenstein , E. J. Cryst. Growth 1977 , 40 , 279 - 290 ; Bhakta , A. ; Ruckenstein , E. J. Chem. Phys. 1995 , 103 , 7120 - 7135 ] is generalized. The processes (not considered in the original approach) of monomer-monomer agglomeration, leading to the creation of dimers, as well as absorption (emission) of dimers by solute particles due to dimer mobility are included in the theory...
January 24, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28047829/th-ab-201-07-filmless-treatment-localization-qa-for-the-cyberknife-system
#9
J Gersh, M Noll
PURPOSE: Accuray recommends daily evaluation of the treatment localization and delivery systems (TLS/TDS) of the CyberKnife. The vendor-provided solution is a Winston-Lutz-type test that evaluates film shadows from an orthogonal beam pair (known as AQA). Since film-based techniques are inherently inefficient and potentially inconsistent and uncertain, this study explores a method which provides a comparable test with greater efficiency, consistency, and certainty. This test uses the QAStereoChecker (QASC, Standard Imaging, Inc...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047803/su-f-t-552-a-one-year-evaluation-of-the-qabeamchecker-for-use-with-the-cyberknife-system
#10
J Gersh
PURPOSE: By attaching an adapter plate with fiducial markers to the QA BeamChecker+ (Standard Imaging, Inc., Middleton, WI), the output of the CyberKnife can be accurately, efficiently, and consistently evaluated. The adapter plate, known as the Cutting Board, allows for automated alignment of the QABC+ using the CK's stereoscopic kV image-based treatment localization system (TLS). Described herein is an evaluation of the system following a year of clinical utilization. METHODS: Based on a CT scan of the QABC+ and CB, a treatment plan is generated which delivers a beam to each of the 5 plane-parallel ionization chambers...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046572/tu-fg-201-09-predicting-accelerator-dysfunction
#11
C Able, C Nguyen, A Baydush, J Gersh, A Ndlovu, I Rebo, J Booth, M Perez, B Sintay, M Munley
PURPOSE: To develop an integrated statistical process control (SPC) framework using digital performance and component data accumulated within the accelerator system that can detect dysfunction prior to unscheduled downtime. METHODS: Seven digital accelerators were monitored for twelve to 18 months. The accelerators were operated in a 'run to failure mode' with the individual institutions determining when service would be initiated. Institutions were required to submit detailed service reports...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034376/predictors-and-prognostic-implications-of%C3%A2-incident-heart-failure-in-patients-with%C3%A2-prevalent-atrial-fibrillation
#12
Ambarish Pandey, Sunghee Kim, Curtiss Moore, Laine Thomas, Bernard Gersh, Larry A Allen, Peter R Kowey, Kenneth W Mahaffey, Elaine Hylek, Eric D Peterson, Jonathan P Piccini, Gregg C Fonarow
OBJECTIVES: The purpose of this study was to determine the significant clinical predictors of incident heart failure (HF) and its prognostic effect on long-term outcomes among community-based patients with established atrial fibrillation (AF). BACKGROUND: AF is associated with an increased risk of HF. However, in this population, little focus is placed on risk stratification for and the prevention of HF. METHODS: Patients with AF but without HF at baseline enrolled in the ORBIT-AF (Outcomes Registry for Informed Treatment of Atrial Fibrillation) registry were included...
January 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28025189/cardiopoietic-cell-therapy-for-advanced-ischemic-heart-failure-results-at-39-weeks-of-the-prospective-randomized-double-blind-sham-controlled-chart-1-clinical-trial
#13
Jozef Bartunek, Andre Terzic, Beth A Davison, Gerasimos S Filippatos, Slavica Radovanovic, Branko Beleslin, Bela Merkely, Piotr Musialek, Wojciech Wojakowski, Peter Andreka, Ivan G Horvath, Amos Katz, Dariouch Dolatabadi, Badih El Nakadi, Aleksandra Arandjelovic, Istvan Edes, Petar M Seferovic, Slobodan Obradovic, Marc Vanderheyden, Nikola Jagic, Ivo Petrov, Shaul Atar, Majdi Halabi, Valeri L Gelev, Michael K Shochat, Jaroslaw D Kasprzak, Ricardo Sanz-Ruiz, Guy R Heyndrickx, Noémi Nyolczas, Victor Legrand, Antoine Guédès, Alex Heyse, Tiziano Moccetti, Francisco Fernandez-Aviles, Pilar Jimenez-Quevedo, Antoni Bayes-Genis, Jose Maria Hernandez-Garcia, Flavio Ribichini, Marcin Gruchala, Scott A Waldman, John R Teerlink, Bernard J Gersh, Thomas J Povsic, Timothy D Henry, Marco Metra, Roger J Hajjar, Michal Tendera, Atta Behfar, Bertrand Alexandre, Aymeric Seron, Wendy Gattis Stough, Warren Sherman, Gad Cotter, William Wijns
AIMS: Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. METHODS AND RESULTS: This multinational, randomized, double-blind, sham-controlled study was conducted in 39 hospitals. Patients with symptomatic ischemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion...
December 23, 2016: European Heart Journal
https://www.readbyqxmd.com/read/28017349/predictors-and-prognostic-implications-of-incident-heart-failure-in-patients-with-prevalent-atrial-fibrillation
#14
Ambarish Pandey, Sunghee Kim, Curtiss Moore, Laine Thomas, Bernard Gersh, Larry A Allen, Peter R Kowey, Kenneth W Mahaffey, Elaine Hylek, Eric D Peterson, Jonathan P Piccini, Gregg C Fonarow
OBJECTIVES: The purpose of this study was to determine the significant clinical predictors of incident heart failure (HF) and its prognostic effect on long-term outcomes among community-based patients with established atrial fibrillation (AF). BACKGROUND: AF is associated with an increased risk of HF. However, in this population, little focus is placed on risk stratification for and the prevention of HF. METHODS: Patients with AF but without HF at baseline enrolled in the ORBIT-AF (Outcomes Registry for Informed Treatment of Atrial Fibrillation) registry were included...
November 30, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/28011796/cardiac-resynchronization-therapy-in-patients-with-end-stage-hypertrophic-cardiomyopathy
#15
Ammar M Killu, Jae-Yoon Park, Jaskanwal D Sara, David O Hodge, Bernard J Gersh, Rick A Nishimura, Samuel J Asirvatham, Christopher J McLeod
AIMS: A dilated/end-stage phase of hypertrophic cardiomyopathy (HCM) is rare but well-recognized. The role for cardiac resynchronization therapy (CRT) in this subset of patients remains unexplored. We aimed to clarify the impact of bi-ventricular pacing CRT in dilated/end-stage HCM. METHODS AND RESULTS: The Mayo Clinic HCM database was interrogated to identify patients with ejection fraction (EF) <50% and CRT. Control subjects were identified in 1:1 manner...
December 23, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28002833/quality-of-evidence-underlying-the-american-heart-association-american-college-of-cardiology-heart-rhythm-society-guidelines-on-the-management-of-atrial-fibrillation
#16
Adam S Barnett, William R Lewis, Michael E Field, Gregg C Fonarow, Bernard J Gersh, Richard L Page, Hugh Calkins, Benjamin A Steinberg, Eric D Peterson, Jonathan P Piccini
Importance: The joint American College of Cardiology (ACC), American Heart Association (AHA), and Heart Rhythm Society (HRS) guidelines on the management of atrial fibrillation (AF) are used extensively to guide patient care. Objective: To describe the evidence base and changes over time in the AHA/ACC/HRS guidelines on AF with respect to the distribution of recommendations across classes of recommendations and levels of evidence. Data Sources: Data from the AHA/ACC/HRS guidelines on AF from 2001, 2006, 2011, and 2014 were abstracted...
March 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/27978942/off-label-dosing-of-non-vitamin-k-antagonist-oral-anticoagulants-and-adverse-outcomes-the-orbit-af-ii-registry
#17
Benjamin A Steinberg, Peter Shrader, Laine Thomas, Jack Ansell, Gregg C Fonarow, Bernard J Gersh, Peter R Kowey, Kenneth W Mahaffey, Gerald Naccarelli, James Reiffel, Daniel E Singer, Eric D Peterson, Jonathan P Piccini
BACKGROUND: Although non-vitamin K antagonist oral anticoagulants (NOACs) do not require frequent laboratory monitoring, each compound requires dose adjustments on the basis of certain clinical criteria. OBJECTIVES: This study assessed the frequency of off-label NOAC doses among AF patients and the associations between off-label dose therapy and clinical outcomes in community practice. METHODS: We evaluated 5,738 patients treated with a NOAC at 242 ORBIT-AF II (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation phase II) sites...
December 20, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27914493/patient-factors-associated-with-quality-of-life-in-atrial-fibrillation
#18
Tiffany C Randolph, DaJuanicia N Simon, Laine Thomas, Larry A Allen, Gregg C Fonarow, Bernard J Gersh, Peter R Kowey, James A Reiffel, Gerald V Naccarelli, Paul S Chan, John A Spertus, Eric D Peterson, Jonathan P Piccini
BACKGROUND: As treatment options for atrial fibrillation (AF) increase, more attention is focused on patients' experiences and quality of life (QoL). However, little is known about the factors associated with these outcomes. METHODS: The Atrial Fibrillation Effect on QualiTy-of-life (AFEQT) is a disease-specific QoL tool for AF, with domain and summary scores ranging from 0 (the worst QoL) to 100. Using multivariable linear regression, we evaluated factors associated with baseline AFEQT Summary and Subscale Scores in ORBIT AF, a large, community-based AF registry...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27903589/impact-of-left-atrial-appendage-closure-during-cardiac-surgery-on-the-occurrence-of-early-postoperative-atrial-fibrillation-stroke-and-mortality-a-propensity-score-matched-analysis-of-10%C3%A2-633-patients
#19
Rowlens M Melduni, Hartzell V Schaff, Hon-Chi Lee, Bernard J Gersh, Peter A Noseworthy, Kent R Bailey, Naser M Ammash, Stephen S Cha, Kaniz Fatema, Waldemar E Wysokinski, James B Seward, Douglas L Packer, Charanjit S Rihal, Samuel J Asirvatham
BACKGROUND: Prophylactic exclusion of the left atrial appendage (LAA) is often performed during cardiac surgery ostensibly to reduce the risk of stroke. However, the clinical impact of LAA closure in humans remains inconclusive. METHODS: Of 10 633 adults who underwent coronary artery bypass grafting and valve surgery between January 2000 and December 2005, 9792 patients with complete baseline characteristics, surgery procedure, and follow-up data were included in this analysis...
January 24, 2017: Circulation
https://www.readbyqxmd.com/read/27888051/absence-of-oral-anticoagulation-and-subsequent-outcomes-among-outpatients-with-atrial-fibrillation
#20
Paul L Hess, Sunghee Kim, Gregg C Fonarow, Laine Thomas, Daniel E Singer, James V Freeman, Bernard J Gersh, Jack Ansell, Peter R Kowey, Kenneth W Mahaffey, Paul S Chan, Benjamin A Steinberg, Eric D Peterson, Jonathan P Piccini
BACKGROUND: Prior studies have shown a treatment gap in oral anticoagulation (OAC) use among patients with atrial fibrillation yet have incompletely characterized factors associated with failure to treat and subsequent outcomes in contemporary practice. METHODS: Using data collected between June 2010 and August 2011 from 174 ambulatory care sites in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation, we identified factors associated with absence of OAC via stratified logistic regression...
November 23, 2016: American Journal of Medicine
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