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https://www.readbyqxmd.com/read/29351847/phosphorylation-of-ezh2-by-ampk-suppresses-prc2-methyltransferase-activity-and-oncogenic-function
#1
Lixin Wan, Kexin Xu, Yongkun Wei, Jinfang Zhang, Tao Han, Christopher Fry, Zhao Zhang, Yao Vickie Wang, Liyu Huang, Min Yuan, Weiya Xia, Wei-Chao Chang, Wen-Chien Huang, Chien-Liang Liu, Yuan-Ching Chang, Jinsong Liu, Yun Wu, Victor X Jin, Xiangpeng Dai, Jianfeng Guo, Jia Liu, Shulong Jiang, Jin Li, John M Asara, Myles Brown, Mien-Chie Hung, Wenyi Wei
Sustained energy starvation leads to activation of AMP-activated protein kinase (AMPK), which coordinates energy status with numerous cellular processes including metabolism, protein synthesis, and autophagy. Here, we report that AMPK phosphorylates the histone methyltransferase EZH2 at T311 to disrupt the interaction between EZH2 and SUZ12, another core component of the polycomb repressive complex 2 (PRC2), leading to attenuated PRC2-dependent methylation of histone H3 at Lys27. As such, PRC2 target genes, many of which are known tumor suppressors, were upregulated upon T311-EZH2 phosphorylation, which suppressed tumor cell growth both in cell culture and mouse xenografts...
January 18, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29346030/the-challenge-of-surgical-sepsis
#2
Donald E Fry
No abstract text is available yet for this article.
January 18, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29333621/characterization-of-mouse-neuro-urological-dynamics-in-a-novel-decerebrate-arterially-perfused-mouse-dapm-preparation
#3
Hiroki Ito, Marcus J Drake, Christopher H Fry, Anthony J Kanai, Anthony E Pickering
AIM: To develop the decerebrate arterially perfused mouse (DAPM) preparation, a novel voiding model of the lower urinary tract (LUT) that enables in vitro-like access with in vivo-like neural connectivity. METHODS: Adult male mice were decerebrated and arterially perfused with a carbogenated, Ringer's solution to establish the DAPM. To allow distinction between central and peripheral actions of interventions, experiments were conducted in both the DAPM and in a "pithed" DAPM which has no brainstem or spinal cord control...
January 15, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29331034/effects-of-in-situ-selenium-exposure-and-maternal-transfer-on-survival-and-deformities-of-brown-trout-salmo-trutta-fry
#4
Sean M Covington, Rami B Naddy, Alan L Prouty, Steven A Werner, Mark Dunn Lewis
Offspring of wild adult brown trout exposed to a range of selenium (Se) concentrations were reared in a laboratory setting to primarily assess effects on survival and deformities. Maternal whole body Se concentrations ranged from 4.7 to 22.6 mg/kg dry weight (dw) for wild fish. Corresponding Se concentrations in embryos ranged from 6.2 to 40.3 mg/kg dw. Significant relationships were found between embryo and whole-body tissue concentrations. Increasing egg Se concentrations were correlated with decreasing survival; however, hatch success was not significantly correlated with increasing embryo Se...
January 13, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29328878/environmental-influences-on-the-epigenome-exposure-associated-dna-methylation-in-human-populations
#5
Elizabeth M Martin, Rebecca C Fry
DNA methylation is the most well studied of the epigenetic regulators in relation to environmental exposures. To date, numerous studies have detailed the manner by which DNA methylation is influenced by the environment, resulting in altered global and gene-specific DNA methylation. These studies have focused on prenatal, early-life, and adult exposure scenarios. The present review summarizes currently available literature that demonstrates a relationship between DNA methylation and environmental exposures. It includes studies on aflatoxin B1, air pollution, arsenic, bisphenol A, cadmium, chromium, lead, mercury, polycyclic aromatic hydrocarbons, persistent organic pollutants, tobacco smoke, and nutritional factors...
January 12, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29324174/r-j-michael-fry-md-1925-2017
#6
John D Boice, Amy Kronenberg, Robert L Ullrich
No abstract text is available yet for this article.
January 2018: Radiation Research
https://www.readbyqxmd.com/read/29317765/-we-want-to-do-everything-how-parents-represent-their-experiences-with-maternal-fetal-surgery-online
#7
Jessica T Fry, Joel E Frader
OBJECTIVE: There is little available evidence on how patients make decisions regarding maternal-fetal surgery. We studied online patient narratives for insight on how pregnant women and their partners consider such decisions. STUDY DESIGN: We used Google search strings and a purposive snowball method to locate patient blogs. We analyzed blog entries using qualitative methods to identify author details, medical information, and common themes. RESULTS: We located 32 blogs of patients who describe maternal-fetal surgery consultation...
January 9, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29311634/variation-in-salinity-tolerance-between-and-within-anadromous-subpopulations-of-pike-esox-1ucius
#8
Johanna Sunde, Carl Tamario, Petter Tibblin, Per Larsson, Anders Forsman
Environmental heterogeneity is a key determinant of genetic and phenotypic diversity. Stable and homogenous environments tends to result in evolution of specialism and local adaptations, while temporally unpredictable environments may maintain a diversity of specialists, promote generalist strategies, or favour diversified bet hedging strategies. We compared salinity tolerance between two anadromous subpopulations of pike (Esox Lucius) that utilize freshwater spawning sites with different salinity regimes. Eggs from each population were artificially fertilized and incubated in a salinity gradient (0, 3, 5, 7, and 9 psu) using a split-brood design...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29309553/characteristics-and-serotype-distribution-of-childhood-cases-of-invasive-pneumococcal-disease-following-pneumococcal-conjugate-vaccination-in-england-and-wales-2006-2014
#9
Godwin Oligbu, Sarah Collins, Nick Andrews, Carmen L Sheppard, Norman K Fry, Mary P E Slack, Ray Borrow, Shamez N Ladhani
Background: The 7-valent and 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13, respectively) are highly effective in preventing invasive pneumococcal disease (IPD) caused by vaccine serotypes. Vaccine failure (vaccine-type IPD after age-appropriate immunization) is rare. Little is known about the risk, clinical characteristics, or outcomes of PCV13 compared to PCV7 vaccine failure. Methods: Public Health England conducts IPD surveillance and provides a national reference service for serotyping pneumococcal isolates in England and Wales...
October 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29309229/evaluating-community-based-health-improvement-programs
#10
Carrie E Fry, Sayeh S Nikpay, Erika Leslie, Melinda B Buntin
Increasingly, public and private resources are being dedicated to community-based health improvement programs. But evaluations of these programs typically rely on data about process and a pre-post study design without a comparison community. To better determine the association between the implementation of community-based health improvement programs and county-level health outcomes, we used publicly available data for the period 2002-06 to create a propensity-weighted set of controls for conducting multiple regression analyses...
January 2018: Health Affairs
https://www.readbyqxmd.com/read/29302933/assessing-the-effect-of-piperacillin-tazobactam-on-hematological-parameters-in-patients-admitted-with-moderate-or-severe-foot-infections
#11
Will Fry, Sean McCafferty, Catherine Gooday, Ian Nunney, Ketan K Dhatariya
INTRODUCTION: Piperacillin/tazobactam is a commonly used antibiotic for the empirical treatment of severe diabetic foot infections. One of the most feared complications of this drug is the development of pancytopenia. The aim of this study was to determine whether the use of piperacillin/tazobactam caused any hematological changes in patients admitted with severe diabetes-related foot infections from a specialist multidisciplinary foot clinic. Specifically, looking at whether it caused anemia, leukopenia, neutropenia, or thrombocytopenia...
January 4, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29298737/a-feasible-model-for-early-intervention-for-high-risk-substance-use-in-the-emergency-department-setting
#12
Rebecca Howard, Stephanie Fry, Andrew Chan, Brigid Ryan, Yvonne Bonomo
Objective In response to escalating alcohol and other drug (AOD)-related emergency department (ED) presentations, a tertiary Melbourne hospital embedded experienced AOD clinical nurse consultants in the ED on weekends to trial a model for screening, assessment and brief intervention (BI). The aim of the present study was to evaluate the relative contributions of AOD to ED presentations and to pilot a BI model.Methods Using a customised AOD screening tool and a framework for proactive case finding, screened participants were offered a comprehensive AOD assessment and BI in the ED...
January 4, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29298069/identification-of-n-cis-3-methyl-7h-pyrrolo-2-3-d-pyrimidin-4-yl-amino-cyclobutyl-propane-1-sulfonamide-pf-04965842-a-selective-jak1-clinical-candidate-for-the-treatment-of-autoimmune-diseases
#13
Michael L Vazquez, Neelu Kaila, Joseph W Strohbach, John D Trzupek, Matthew F Brown, Mark E Flanagan, Mark J MItton-Fry, Timothy A Johnson, Ruth E TenBrink, Eric P Arnold, Arindrajit Basak, Steven E Heasley, Soojin Kwon, Jonathan Langille, Mihir D Parikh, Sarah H Griffin, Jeffrey M Casavant, Brian A Duclos, Ashley E Fenwick, Thomas M Harris, Seungil Han, Nicole L Caspers, Martin E Dowty, Xin Yang, Mary Ellen Banker, Martin Hegen, Peter T Symanowicz, Li Li, Lu Wang, Tsung H Lin, Jason Jussif, James D Clark, Jean-Baptiste Telliez, Ralph P Robinson, Ray Unwalla
Janus kinases (JAKs) are intracellular tyrosine kinases that mediate the signaling of numerous cytokines and growth factors involved in the regulation of immunity, inflammation and hematopoiesis. As JAK1 pairs with JAK2, JAK3 and TYK2, a JAK1-selective inhibitor would be expected to inhibit many cytokines involved in inflammation and immune function, while avoiding inhibition of the JAK2 homodimer regulating EPO and TPO signaling. Our efforts began with tofacitinib, an oral JAK inhibitor approved for the treatment of rheumatoid arthritis (RA)...
January 3, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29296821/progenitor-b-1-b-cell-acute-lymphoblastic-leukemia-is-associated-with-collaborative-mutations-in-3-critical-pathways
#14
Sheryl M Gough, Liat Goldberg, Marbin Pineda, Robert L Walker, Yuelin J Zhu, Sven Bilke, Yang Jo Chung, Joseph Dufraine, Subhadip Kundu, Elad Jacoby, Terry J Fry, Susanna Fischer, Renate Panzer-Grümayer, Paul S Meltzer, Peter D Aplan
B-1 and B-2 lymphocytes are derived from distinct developmental pathways and represent layered arms of the innate and adaptive immune systems, respectively. In contrast to a majority of murine B-cell malignancies, which stain positive with the B220 antibody, we discovered a novel form of B-cell leukemia in NUP98-PHF23 (NP23) transgenic mice. The immunophenotype (Lin- B220- CD19+ AA4.1+) was identical to that of progenitor (pro) B-1 cells, and VH gene usage was skewed toward 3' V regions, similar to murine fetal liver B cells...
September 12, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295926/preservation-of-the-genetic-diversity-of-a-local-common-carp-in-the-agricultural-heritage-rice-fish-system
#15
Weizheng Ren, Liangliang Hu, Liang Guo, Jian Zhang, Lu Tang, Entao Zhang, Jiaen Zhang, Shiming Luo, Jianjun Tang, Xin Chen
We examined how traditional farmers preserve the genetic diversity of a local common carp (Cyprinus carpio), which is locally referred to as "paddy field carp" (PF-carp), in a "globally important agricultural heritage system" (GIAHS), i.e., the 1,200-y-old rice-fish coculture system in Zhejiang Province, China. Our molecular and morphological analysis showed that the PF-carp has changed into a distinct local population with higher genetic diversity and diverse color types. Within this GIAHS region, PF-carps exist as a continuous metapopulation, although three genetic groups could be identified by microsatellite markers...
January 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29285672/stimulatory-effect-of-dietary-taurine-on-growth-performance-digestive-enzymes-activity-antioxidant-capacity-and-tolerance-of-common-carp-cyprinus-carpio-l-fry-to-salinity-stress
#16
Mohsen Abdel-Tawwab, Mohamed N Monier
The present study was carried out to evaluate the effect of dietary taurine (Tau) on performance, digestive enzymes, antioxidant activity, and resistance of common carp, Cyprinus carpio L., fry to salinity stress. Fish (0.97 ± 0.033 g) were fed on different taurine levels of 0.0 (control), 5, 10, 15, or 20 g/kg diet up to satiation twice daily for 8 weeks. At the end of the feeding trial, fish were stressed by exposure to 10 ppt salinity for 3 days during which fish mortality was observed. Fish performance was significantly (P < 0...
December 28, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29284423/the-relationship-between-lower-limb-muscle-volume-and-body-mass-in-ambulant-individuals-with-bilateral-cerebral-palsy
#17
Jonathan J Noble, Emily Chruscikowski, Nicola R D Fry, Andrew P Lewis, Martin Gough, Adam P Shortland
BACKGROUND: Individuals with cerebral palsy have smaller muscle volumes normalised to body mass than their typically developing peers. The aim of this study is to investigate the relationship between lower limb muscle volume and body mass in young people with bilateral cerebral palsy and their typically developing peers. METHODS: Twenty-five participants with bilateral cerebral palsy (aged 14.7±3.0 years, GMFCS level I-III) and 25 of their typically developing peers (aged 16...
December 29, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29284198/signals-from-the-south-humpback-whales-carry-messages-of-antarctic-sea-ice-ecosystem-variability
#18
Susan M Bengtson Nash, Juliana Castrillon, Pascale Eisenmann, Brian Fry, Jon D Shuker, Roger A Cropp, Amanda Dawson, Anders Bignert, Pernilla Bohlin-Nizzetto, Courtney A Waugh, Bradley J Polkinghorne, Greta Dalle Luche, David McLagan
Southern hemisphere humpback whales (Megaptera novaeangliae) rely on summer prey abundance of Antarctic krill (Euphausia superba) to fuel one of the longest-known mammalian migration on the planet. It is hypothesised that this species, already adapted to endure metabolic extremes, will be one of the first Antarctic consumers to show measurable physiological change in response to fluctuating prey availability in a changing climate; and as such, a powerful sentinel candidate for the Antarctic sea-ice ecosystem...
December 28, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29283929/the-effect-of-three-different-maximal-concentric-velocity-squat-protocols-on-mapk-phosphorylation-and-endocrine-responses
#19
Rebecca A Kudrna, Andrew C Fry, Justin X Nicoll, Phillip M Gallagher, Michael R Prewitt
The purpose of this study was to determine the effect of three different back squat protocols on intra-cellular signaling, endocrine responses, and power fatigue. Nine recreationally trained males (X±SD; age: 21.4±0.6yrs; height: 177.8±5.1cm; weight: 78.7±9.7kg), completed three maximal concentric velocity squat protocols in a randomized order. Testing protocols consisted of 5 sets of 10 repetitions at 30% of 1RM; 5 sets of 5 repetitions at 70% of 1RM; and 5 sets of 3 repetitions at 90% of 1RM. Average system power for each set was obtained with a tethered external dynamometer...
December 27, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29283018/a-practical-clinical-kinematic-model-for-the-upper-limbs
#20
Jonathan J Noble, Nicola Rd Fry, Carly R Bingham, Rebecca H East, Adam P Shortland
A novel clinically practical upper limb model is introduced that has been developed through clinical use in children and adults with neurological conditions to guide surgery to the elbow and wrist. This model has a minimal marker set, minimal virtual markers, and no functional joint centres to minimise the demands on the patient and duration of data collection. The model calculates forearm supination independently from the humerus segment, eliminating any errors introduced by poor modelling of the shoulder joint centre...
December 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
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