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https://www.readbyqxmd.com/read/28535381/the-evolution-of-fangs-venom-and-mimicry-systems-in-blenny-fishes
#1
Nicholas R Casewell, Jeroen C Visser, Kate Baumann, James Dobson, Han Han, Sanjaya Kuruppu, Michael Morgan, Anthony Romilio, Vera Weisbecker, Karine Mardon, Syed A Ali, Jordan Debono, Ivan Koludarov, Ivo Que, Gregory C Bird, Gavan M Cooke, Amanda Nouwens, Wayne C Hodgson, Simon C Wagstaff, Karen L Cheney, Irina Vetter, Louise van der Weerd, Michael K Richardson, Bryan G Fry
No abstract text is available yet for this article.
May 22, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28534833/coagulating-colubrids-evolutionary-pathophysiological-and-biodiscovery-implications-of-venom-variations-between-boomslang-dispholidus-typus-and-twig-snake-thelotornis-mossambicanus
#2
Jordan Debono, James Dobson, Nicholas R Casewell, Anthony Romilio, Bin Li, Nyoman Kurniawan, Karine Mardon, Vera Weisbecker, Amanda Nouwens, Hang Fai Kwok, Bryan G Fry
Venoms can deleteriously affect any physiological system reachable by the bloodstream, including directly interfering with the coagulation cascade. Such coagulopathic toxins may be anticoagulants or procoagulants. Snake venoms are unique in their use of procoagulant toxins for predatory purposes. The boomslang (Dispholidus typus) and the twig snakes (Thelotornis species) are iconic African snakes belonging to the family Colubridae. Both species produce strikingly similar lethal procoagulant pathologies. Despite these similarities, antivenom is only produced for treating bites by D...
May 19, 2017: Toxins
https://www.readbyqxmd.com/read/28534487/rules-of-engagement-between-%C3%AE-v%C3%AE-6-integrin-and-foot-and-mouth-disease-virus
#3
Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E Fry, Nicola G A Abrescia, Timothy A Springer, Juha T Huiskonen, David I Stuart
Foot-and-mouth disease virus (FMDV) mediates cell entry by attachment to an integrin receptor, generally αvβ6, via a conserved arginine-glycine-aspartic acid (RGD) motif in the exposed, antigenic, GH loop of capsid protein VP1. Infection can also occur in tissue culture adapted virus in the absence of integrin via acquired basic mutations interacting with heparin sulphate (HS); this virus is attenuated in natural infections. HS interaction has been visualized at a conserved site in two serotypes suggesting a propensity for sulfated-sugar binding...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28530571/novel-insights-into-ascorbate-retention-and-degradation-during-the-washing-and-post-harvest-storage-of-spinach-and-other-salad-leaves
#4
Rebecca A Dewhirst, Graham J J Clarkson, Steve D Rothwell, Stephen C Fry
Post-harvest treatments of pre-packaged salad leaves potentially cause l-ascorbate loss, but the mechanisms of ascorbate degradation remain incompletely understood, especially in planta. We explored the extent and pathways of ascorbate loss in variously washed and stored salad leaves. Ascorbate was assayed by 2,6-dichlorophenolindophenol titration, and pathways were monitored by (14)C-radiolabelling followed by high-voltage electrophoresis. All leaves tested showed ascorbate loss during storage: lettuce showed the greatest percentage loss, wild rocket the least...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28529018/effects-of-anandamide-administration-on-components-of-reward-processing-during-free-choice
#5
Luke C Zona, Benjamin R Fry, Jacob A LaLonde, Howard C Cromwell
Previous research has implicated the positive modulation of anandamide, an endocannabinoid neurotransmitter, on feeding behavior. Anandamide is particularly noteworthy as it acts as an endogenous ligand of the CB1 receptor, the same receptor that is activated by tetrahydrocannabinol, the primary psychoactive component in Cannabis sativa. Cannabis legalization in North America has presented with a need to study endocannabinoid agonists and their effects on behavior. Much has yet to be determined in terms of the role of the endocannabinoid system in decision-making scenarios...
May 18, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28525597/influenza-vaccination-modifies-disease-severity-among-community-dwelling-adults-hospitalized-with-influenza
#6
Carmen Sofia Arriola, Shikha Garg, Evan J Anderson, Patricia A Ryan, Andrea George, Shelley M Zansky, Nancy Bennett, Arthur Reingold, Marisa Bargsten, Lisa Miller, Kimberly Yousey-Hindes, Lilian Tatham, Susan R Bohm, Ruth Lynfield, Ann Thomas, Mary Lou Lindegren, William Schaffner, Alicia M Fry, Sandra S Chaves
Background: We investigated the effect of influenza vaccination on disease severity in adults hospitalized with laboratory-confirmed influenza during 2013-14, a season in which vaccine viruses were antigenically similar to those circulating. Methods: We analyzed data from the 2013-14 influenza season, and used propensity score matching to account for the probability of vaccination within age strata (18-49, 50-64 and ≥65 years). Death, intensive care unit (ICU) admission, and hospital and ICU lengths of stay (LOS) were outcome measures for severity...
May 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28509541/synthesis-characterization-and-variable-temperature-nmr-studies-of-silver-i-complexes-for-selective-nitrene-transfer
#7
Minxue Huang, Joshua R Corbin, Nicholas S Dolan, Charles G Fry, Anastasiya I Vinokur, Ilia A Guzei, Jennifer M Schomaker
An array of silver complexes supported by nitrogen-donor ligands catalyze the transformation of C═C and C-H bonds to valuable C-N bonds via nitrene transfer. The ability to achieve high chemoselectivity and site selectivity in an amination event requires an understanding of both the solid- and solution-state behavior of these catalysts. X-ray structural characterizations were helpful in determining ligand features that promote the formation of monomeric versus dimeric complexes. Variable-temperature (1)H and DOSY NMR experiments were especially useful for understanding how the ligand identity influences the nuclearity, coordination number, and fluxional behavior of silver(I) complexes in solution...
May 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28505436/control-of-heme-coordination-and-catalytic-activity-by-conformational-changes-in-peptide-amphiphile-assemblies
#8
Lee Andrew Solomon, Jacob Kronenberg, H Christopher Fry
Self-Assembling peptide materials have gained significant attention, due to well-demonstrated applications, but are functionally underutilized. To advance their utility, we use non-covalent interactions to incorporate the biological cofactor heme-B for catalysis. Heme-proteins achieve differing functions through structural and coordinative variations. Here, we replicate this phenomenon by highlighting changes in heme reactivity as a function of coordination, sequence, and morphology (micelles versus fibers) in a series of simple peptide-amphiphiles with the sequence c16-xyL3K3-CO2H...
May 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28501357/medicaid-reform-key-considerations-for-children-s-health-care
#9
Eileen K Fry-Bowers, Karen G Duderstadt
No abstract text is available yet for this article.
May 10, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28498878/the-malleable-gut-microbiome-of-juvenile-rainbow-trout-oncorhynchus-mykiss-diet-dependent-shifts-of-bacterial-community-structures
#10
Stéphanie Céline Michl, Jenni-Marie Ratten, Matt Beyer, Mario Hasler, Julie LaRoche, Carsten Schulz
Plant-derived protein sources are the most relevant substitutes for fishmeal in aquafeeds. Nevertheless, the effects of plant based diets on the intestinal microbiome especially of juvenile Rainbow trout (Oncorhynchus mykiss) are yet to be fully investigated. The present study demonstrates, based on 16S rDNA bacterial community profiling, that the intestinal microbiome of juvenile Rainbow trout is strongly affected by dietary plant protein inclusion levels. After first feeding of juveniles with either 0%, 50% or 97% of total dietary protein content derived from plants, statistically significant differences of the bacterial gut community for the three diet-types were detected, both at phylum and order level...
2017: PloS One
https://www.readbyqxmd.com/read/28497996/characterization-of-the-salmonella-enterica-serotype-isangi-isolated-from-patients-for-the-first-time-in-china
#11
Xin-Peng Li, Ri-Hong Gao, Pei-Bin Hou, Yan-Yan Ren, Hua-Ning Zhang, Kui-Ying Jiang, Yu-Zhen Chen, Zi-Gang Qi, Min Xu, Zhen-Wang Bi
No studies have reported the isolation of serotype Salmonella Isangi from cases of salmonellosis in mainland China. We investigated an outbreak of foodborne disease with salmonella and collected the samples from the patients and surplus foods. Salmonella strains were isolated and the serotype was identified according to the Kauffmann-White scheme. The relatedness of the isolates was determined using pulsed-field gel electrophoresis (PFGE) and whole genome sequencing (WGS). Antimicrobial susceptibility was conducted by the broth microdilution method...
May 12, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28495905/long-term-outcomes-of-the-boston-type-i-keratoprosthesis-in-eyes-with-previous-herpes-simplex-virus-keratitis
#12
Melinda Fry, Carolina Aravena, Fei Yu, Jaffer Kattan, Anthony J Aldave
PURPOSE: To report the long-term outcomes of the Boston type I keratoprosthesis (Kpro) in eyes with prior herpes simplex virus (HSV) keratitis. METHODS: Retrospective review of all Kpro procedures performed by a single surgeon from 1 May 2004 to 1 January 2015. RESULTS: 13 of 173 Kpro procedures were performed in 11 eyes with prior HSV keratitis. There was not a significant difference in the percentage of eyes with and without prior HSV keratitis with preoperative (9% vs 8%, p=1...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28495544/modeling-glucose-metabolism-and-lactate-production-in-the-kidney
#13
Ying Chen, Brendan C Fry, Anita T Layton
The metabolism of glucose provides most of the ATP required for energy-dependent transport processes. In the inner medulla of the mammalian kidney, limited blood flow and O2 supply yield low oxygen tension; therefore, a substantial fraction of the glucose metabolism in that region is anaerobic. Lactate is considered to be a waste product of anaerobic glycolysis, which yields two lactate molecules for each glucose molecule consumed, thereby likely leading to the production and accumulation of a significant amount of lactate in the inner medulla...
May 8, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28494845/monitoring-influenza-virus-susceptibility-to-oseltamivir-using-a-new-rapid-assay-iart
#14
Larisa V Gubareva, Eric Fallows, Vasiliy P Mishin, Erin Hodges, Abdullah Brooks, John Barnes, Alicia M Fry, William Kramp, Roxanne Shively, David E Wentworth, Kristin Weidemaier, Ross Jacobson
A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as 'resistant'. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such markers were detected for the remaining 91 samples. Viruses isolated from the 41 specimens showed reduced or highly reduced inhibition by neuraminidase inhibition assay. iART may facilitate broader antiviral resistance testing...
May 4, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28493900/genomic-biomarkers-of-prenatal-intrauterine-inflammation-in-umbilical-cord-tissue-predict-later-life-neurological-outcomes
#15
Sloane K Tilley, Robert M Joseph, Karl C K Kuban, Olaf U Dammann, T Michael O'Shea, Rebecca C Fry
BACKGROUND: Preterm birth is a major risk factor for neurodevelopmental delays and disorders. This study aimed to identify genomic biomarkers of intrauterine inflammation in umbilical cord tissue in preterm neonates that predict cognitive impairment at 10 years of age. STUDY DESIGN: Genome-wide messenger RNA (mRNA) levels from umbilical cord tissue were obtained from 43 neonates born before 28 weeks of gestation. Genes that were differentially expressed across four indicators of intrauterine inflammation were identified and their functions examined...
2017: PloS One
https://www.readbyqxmd.com/read/28492869/effects-of-magnification-on-emotion-perception-in-patients-with-age-related-macular-degeneration
#16
Aaron P Johnson, Heather Woods-Fry, Walter Wittich
Purpose: Individuals with low vision often experience difficulties in performing tasks of daily living, such as face perception. This leads them to having difficulties with social interactions, as they can no longer correctly perceive the emotion of others. The present study investigated the effects of magnification on face perception in participants with age-related macular degeneration (AMD), and their ability to detect and categorize emotions. It was hypothesized that patients with AMD would be less accurate in comparison to healthy controls, but that magnification would improve their performance to that of controls...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28492177/characterization-of-aliivibrio-fischeri-strains-associated-with-disease-outbreak-in-brill-scophthalmus-rhombus
#17
Jose R López, Laura Lorenzo, Rafael Alcantara, J I Navas
Three bacterial isolates were recovered from a disease outbreak with high mortality affecting brill Scophthalmus rhombus (Linnaeus, 1758). Moribund fish showed no external signs of disease, but plentiful haemorrhages were observed in liver. On the basis of phenotypic and genotypic characterization, the isolates were identified as Aliivibrio fischeri. The phenotypic profile of the isolates was basically similar to that of the type strain of this species, although some discrepancies were observed, mainly in the BIOLOG GN profile...
May 11, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28488934/the-zebrafish-curly-fry-is-required-for-proper-centrosome-and-mitotic-spindle-assembly
#18
Mi Hye Song, Jeffrey C Medley, John Y Kuwada
The zebrafish curly fry (cfy) mutation leads to a dramatic increase in mitotic index and cell death starting during neural tube formation. The mutant phenotype is cell autonomous and does not result from defects in apical/basal polarity within the neuroepithelium. The increase in mitotic index could be due to increased proliferation or cell cycle arrest in mitosis. cfy embryos were analyzed to examine these two possibilities. By labeling embryos with a pulse of BrdU and anti-phospho-histone 3 and examining the DNA content by fluorescence activated cell sorting, we show that cfy mutants exhibit no increase in proliferation, but a significant increase in the number of cells arrested in mitosis...
May 10, 2017: Zebrafish
https://www.readbyqxmd.com/read/28488356/early-life-traits-of-farm-and-wild-atlantic-salmon-salmo-salar-and-first-generation-hybrids-in-the-south-coast-of-newfoundland
#19
D Hamoutene, J Perez-Casanova, K Burt, L Lush, J Caines, C Collier, R Hinks
This study examined fertilization rates, survival and early life-trait differences of pure farm, wild and first generation (F1) hybrid origin embryos after crossing farm and wild Atlantic salmon Salmo salar. Results show that despite a trend towards higher in vitro fertilization success for wild females, differences in fertilization success in river water are not significantly different among crosses. In a hatchery environment, wild females' progeny (pure wild and hybrids with wild maternal parent) hatched 7-11 days earlier than pure farm crosses and hybrids with farm maternal parents...
May 9, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28481871/suppression-of-planar-cell-polarity-signaling-and-migration-in-glioblastoma-by-nrdp1-mediated-dvl-polyubiquitination
#20
J H Wald, J Hatakeyama, I Printsev, A Cuevas, W H D Fry, M J Saldana, K VanderVorst, A Rowson-Hodel, J M Angelastro, C Sweeney, K L Carraway Rd
The lethality of the aggressive brain tumor glioblastoma multiforme (GBM) results in part from its strong propensity to invade surrounding normal brain tissue. Although oncogenic drivers such as epidermal growth factor receptor activation and Phosphatase and Tensin homolog inactivation are thought to promote the motility and invasiveness of GBM cells via phosphatidylinostitol 3-kinase activation, other unexplored mechanisms may also contribute to malignancy. Here we demonstrate that several components of the planar cell polarity (PCP) arm of non-canonical Wnt signaling including VANGL1, VANGL2 and FZD7 are transcriptionally upregulated in glioma and correlate with poorer patient outcome...
May 8, 2017: Oncogene
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