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https://www.readbyqxmd.com/read/28412598/effect-of-two-isolated-vocal-facilitating-techniques-glottal-fry-and-yawn-sigh-on-the-phonation-of-female-speech-language-pathology-students-a-pilot-study
#1
I Meerschman, E D'haeseleer, T Catry, B Ruigrok, S Claeys, K Van Lierde
OBJECTIVE: The purpose of this study was to determine the effect of two isolated vocal facilitating techniques, glottal fry and yawn-sigh, on the phonation of vocally healthy female speech-language pathology (SLP) students. STUDY DESIGN: A multigroup pretest-posttest design was used. METHODS: A group of thirty-six healthy female SLP students with a mean age of 18.1 years were assigned into three groups: a glottal fry group (practicing the facilitating technique glottal fry across 18 weeks, n=12), a yawn-sigh group (practicing the facilitating technique yawn-sigh across 18 weeks, n=12) and a control group (receiving no facilitating techniques, n=12)...
March 27, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28411089/evidence-for-polymicrobial-communities-in-explanted-vascular-filters-and-atheroma-debris
#2
Jeremy E Ellis, Richard Heuser, Dara S Missan, Delyn Martinez, Avory Heningburg, Matthew Shabilla, Renata Schwartz, Stephen Fry
RATIONALE: Microbial communities have been implicated in a variety of disease processes and have been intermittently observed in arterial disease; however, no comprehensive unbiased community analysis has been performed. We hypothesize that complex microbial communities may be involved in chronic vascular diseases as well and may be effectively characterized by molecular assays. OBJECTIVE: The main objective is to survey vascular debris, atheroma, and vascular filters for polymicrobial communities consisting of prokaryotic and eukaryotic microbes, specifically eukaryotic microbes...
April 11, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28409421/the-impact-of-microenvironment-on-the-synovial-sarcoma-transcriptome
#3
Huifeng Jin, Jared J Barrott, Matthew G Cable, Michael J Monument, Daniel M Lerman, Kyllie Smith-Fry, Dakota Nollner, Kevin B Jones
Synovial sarcoma (SS) is initiated by a t(X;18) chromosomal translocation and resultant SS18-SSX fusion oncogene. Only a few SS cell lines exist. None has been compared to its source tumor. In order to compare matched tumor and cell line pairs, we performed RNAseq on 3 tumor/cell line pairs from a genetically engineered mouse model of SS, as well as 2 pairs from human SS tumors. Transcriptomes of mouse tumors and derivative cell lines deviated significantly. Differentially expressed genes highlighted inflammatory infiltrates and metabolism...
April 13, 2017: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/28406729/stabilization-of-the-p53-dna-complex-by-the-nuclear-protein-dmp1%C3%AE
#4
Robert D Kendig, Fumitake Kai, Elizabeth A Fry, Kazushi Inoue
We recently reported the existence of a physical interaction between the Myb-like transcription factor Dmp1 (Dmtf1) and p53 in which Dmp1 antagonized polyubiquitination of p53 by Mdm2 and promoted its nuclear localization. Dmp1 significantly stabilized p53-DNA complexes on promoters that contained p53-consensus sequences, which were either supershifted or disrupted with antibodies to Dmp1. Lysates from mice injected with doxorubicin showed that Dmp1 bound to p21(Cip1), Bbc3, and Thbs1 gene regulatory regions in a p53-dependent fashion...
April 13, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28395834/understanding-the-linkages-between-violence-against-women-and-violence-against-children
#5
Deborah A Fry, Stuart P Elliott
No abstract text is available yet for this article.
May 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28391392/reliability-of-quadriceps-surface-electromyography-measurements-is-improved-by-two-vs-single-site-recordings
#6
T G Balshaw, A Fry, T M Maden-Wilkinson, P W Kong, J P Folland
PURPOSE: The reliability of surface electromyography (sEMG) is typically modest even with rigorous methods, and therefore further improvements in sEMG reliability are desirable. This study compared the between-session reliability (both within participant absolute reliability and between-participant relative reliability) of sEMG amplitude from single vs. average of two distinct recording sites, for individual muscle (IM) and whole quadriceps (WQ) measures during voluntary and evoked contractions...
April 8, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28382781/heteronormativity-and-prostate-cancer-a-discursive-paper
#7
Daniel Kelly, Dikaios Sakellariou, Sarah Fry, Sofia Vougioukalou
AIMS AND OBJECTIVES: To discuss the risks that heteronormative assumptions play in prostate cancer care and how these may be addressed. BACKGROUND: There is international evidence to support the case that LGBT cancer patients are less likely to report poor health or self-disclose sexual orientation. Gender-specific cancers, such as prostate cancer, require particular interventions in terms of supportive care. These may include advice about side-effect management (such as incontinence or erectile dysfunction), treatment choices and social and emotional issues...
April 5, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28379446/50-important-research-questions-in-microbial-ecology
#8
Rachael E Antwis, Sarah M Griffiths, Xavier A Harrison, Paz Aranega-Bou, Andres Arce, Aimee S Bettridge, Francesca L Brailsford, Alexandre de Menezes, Andrew Devaynes, Kristian M Forbes, Ellen L Fry, Ian Goodhead, Erin Haskell, Chloe Heys, Chloe James, Sarah R Johnston, Gillian R Lewis, Zenobia Lewis, Michael C Macey, Alan McCarthy, James E McDonald, Nasmille L Mejia-Florez, David O'Brien, Chloé Orland, Marco Pautasso, William D K Reid, Heather A Robinson, Kenneth Wilson, William J Sutherland
Microbial ecology provides insights into the ecological and evolutionary dynamics of microbial communities underpinning every ecosystem on Earth. Microbial communities can now be investigated in unprecedented detail, although there is still a wealth of open questions to be tackled. Here we identify 50 research questions of fundamental importance to the science or application of microbial ecology, with the intention of summarising the field and bringing focus to new research avenues. Questions are categorised into seven themes: Host-Microbiome Interactions; Health and Infectious Diseases; Human Health and Food Security; Microbial Ecology in a Changing World; Environmental Processes; Functional Diversity; and Evolutionary Processes...
April 3, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28378824/chemical-inhibition-reveals-differential-requirements-of-signaling-pathways-in-kras-v12-and-myc-induced-liver-tumors-in-transgenic-zebrafish
#9
Chuan Yan, Qiqi Yang, Xiaojing Huo, Hankun Li, Li Zhou, Zhiyuan Gong
Previously we have generated inducible liver tumor models by transgenic expression of an oncogene and robust tumorigenesis can be rapidly induced by activation of the oncogene in both juvenile and adult fish. In the present study, we aimed at chemical intervention of tumorigenesis for understanding molecular pathways of tumorigenesis and for potential development of a chemical screening tool for anti-cancer drug discovery. Thus, we evaluated the roles of several major signaling pathways in kras(V12)- or Myc-induced liver tumors by using several small molecule inhibitors: SU5402 and SU6668 for VEGF/FGF signaling; IWR1 and cardionogen 1 for Wnt signaling; and cyclopamine and Gant61 for Hedgehog signaling...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28371738/abnormality-of-standing-posture-improves-in-patients-with-bilateral-spastic-cerebral-palsy-following-lower-limb-surgery
#10
P Buddhdev, N R Fry, R LePage, M Wiley, M Gough, A P Shortland
OBJECTIVES: The degree of abnormality of the gait pattern of children with bilateral spastic cerebral palsy (BSCP) can be reduced by lower limb orthopaedic surgery. However, little attention is paid to the effects of surgery on standing posture. Here, we investigated the abnormality of standing posture in young people with BSCP as well as the effects of surgery on standing posture. METHODS: We have developed an index of standing posture, the Standing Posture Score (SPS), which is similar in composition to the gait profile score (GPS)...
March 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28370992/cortical-adaptations-during-muscle-fatigue-the-role-of-sensorimotor-oscillations
#11
EDITORIAL
Tjeerd W Boonstra
During physical activity, fatigue arises not only from peripheral processes within the active spinal motor units but also from supraspinal mechanisms within the brain. Although the failure to generate a maximal output from the motor cortex is well established, the neural mechanisms of central fatigue remain unclear. In a recent study, Fry et al. (1) investigate changes in oscillatory activity in sensorimotor cortex following a fatiguing intervention to identify the cortical adaptations to muscle fatigue. This article is protected by copyright...
March 29, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28370005/cold-sweetening-diversity-in-andean-potato-germplasm-from-argentina
#12
Silvana L Colman, Gabriela A Massa, Martín F Carboni, Sergio E Feingold
BACKGROUND: Cold-induced sweetening (CIS) is the accumulation of sucrose and reducing sugars in potato tubers at low temperatures. This process is central for the potato processing industry. During potato chip and French fry production, reducing sugars participate in the Maillard reaction to produce dark pigmented products not acceptable to consumers. Andean potatoes (Solanum tuberosum Group Andigena) constitute an enormous wealth of potato germplasm that can contribute to increase genetic diversity in breeding programs of many traits, including CIS...
April 2, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28366739/the-evolution-of-fangs-venom-and-mimicry-systems-in-blenny-fishes
#13
Nicholas R Casewell, Jeroen C Visser, Kate Baumann, James Dobson, Han Han, Sanjaya Kuruppu, Michael Morgan, Anthony Romilio, Vera Weisbecker, Syed A Ali, Jordan Debono, Ivan Koludarov, Ivo Que, Gregory C Bird, Gavan M Cooke, Amanda Nouwens, Wayne C Hodgson, Simon C Wagstaff, Karen L Cheney, Irina Vetter, Louise van der Weerd, Michael K Richardson, Bryan G Fry
Venom systems have evolved on multiple occasions across the animal kingdom, and they can act as key adaptations to protect animals from predators [1]. Consequently, venomous animals serve as models for a rich source of mimicry types, as non-venomous species benefit from reductions in predation risk by mimicking the coloration, body shape, and/or movement of toxic counterparts [2-5]. The frequent evolution of such deceitful imitations provides notable examples of phenotypic convergence and are often invoked as classic exemplars of evolution by natural selection...
March 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28364922/understanding-the-policy-environment-for-immunization-supply-chains-lessons-learned-from-landscape-analyses-in-uganda-and-senegal
#14
Henry Luzze, Ousseynou Badiane, El Hadji Mamadou Ndiaye, Annette Seck Ndiaye, Brian Atuhaire, Phionah Atuhebwe, Phillippe Guinot, Erin Fry Sosne, Abdoulaye Gueye
As immunization programs around the world undergo rapid change and expansion, supply chain and logistics systems have become strained, making it increasingly challenging for national public health systems to provide reliable, safe, and efficient access to vaccines. Governments and immunization partners have been aware of this problem for several years, and in 2010, the World Health Organization (WHO) launched the Effective Vaccine Management (EVM) process to help countries identify shortcomings in their immunization supply chains and develop plans for systematic improvement...
April 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28362162/hypoxia-and-hypoglycemia-synergistically-regulate-mrna-stability
#15
Kristen R Carraway, Ellen M Johnson, Travis C Kauffmann, Nate J Fry, Kyle D Mansfield
Ischemic events, common in many diseases, result from decreased blood flow and impaired delivery of oxygen and glucose to tissues of the body. While much is known about the cellular transcriptional response to ischemia, much less is known about the posttranscriptional response to oxygen and glucose deprivation. The goal of this project was to investigate one such posttranscriptional response, the regulation of mRNA stability. To that end, we have identified a number of novel ischemia-related mRNAs that are synergistically stabilized by oxygen and glucose deprivation including VEGF, MYC, MDM2, and CYR61...
March 31, 2017: RNA Biology
https://www.readbyqxmd.com/read/28361040/different-phenotypes-of-mature-biofilm-in-flavobacterium-psychrophilum-share-a-potential-for-virulence-that-differs-from-planktonic-state
#16
Héctor A Levipan, Ruben Avendaño-Herrera
Flavobacterium psychrophilum is the etiological agent of bacterial coldwater disease and the rainbow trout fry syndrome in salmonid aquaculture worldwide. However, there have been few studies into the capacity of F. psychrophilum to form biofilms and how these cellular accretions differ from planktonic cells or how they affect potential virulence. We evaluated the biofilm formation by three Chilean isolates of F. psychrophilum (LM-02-Fp, LM-06-Fp, and LM-13-Fp) and two non-Chilean strains (JIP02/86 and NCMB1947(T)), and compared biofilm and planktonic states to obtain insights into expression differences of virulence- and biofilm-related genes (VBRGs)...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28358320/from-marine-venoms-to-drugs-efficiently-supported-by-a-combination-of-transcriptomics-and-proteomics
#17
REVIEW
Bing Xie, Yu Huang, Kate Baumann, Bryan Grieg Fry, Qiong Shi
The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), it has been much easier and faster to identify more toxins and predict their functions with bioinformatics pipelines, which pave the way for novel drug developments...
March 30, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28357988/isolation-of-lacinutrix-venerupis-strains-associated-with-disease-outbreaks-in-sea-bream-sparus-aurata-and-european-sea-bass-dicentrarchus-labrax
#18
Jose R López, Rafael Alcantara, Laura Lorenzo, J I Navas
Four Gram-negative bacterial isolates were recovered from 2 disease outbreaks that occurred in 2013 affecting European sea bass Dicentrarchus labrax fry and sea bream Sparus aurata adults. Main symptoms were erratic swimming, eroded fins and, in the sea bream outbreak, haemorrhages on the body surface; bacteria were always recovered from internal organs, almost in pure culture. On the basis of phenotypic characterization and 16S rRNA gene sequence analysis, the isolates were identified as Lacinutrix venerupis, a bacterium not previously reported as a fish pathogen...
March 30, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28357045/growth-performance-and-feed-utilization-of-keureling-fish-tor-tambra-cyprinidae-fed-formulated-diet-supplemented-with-enhanced-probiotic
#19
Zainal Abidin Muchlisin, Tanzil Murda, Cut Yulvizar, Irma Dewiyanti, Nur Fadli, Fardin Afrido, Mohd Nor Siti-Azizah, Abdullah A Muhammadar
Background The objective of the present study was to determine the optimum dosage of probiotic in the diet of keureling fish ( Tor tambra) fry. MethodsLactobacillus casei from Yakult® was used as a starter, and enhanced with Curcuma xanthorrhiza, Kaempferia galanga and molasses. The mixture was fermented for 7 days prior to use as probiotic in a formulated diet containing 30% crude protein. Four levels of probiotic dosage; 0 ml kg (-1) (control), 5 ml kg (-1), 10 ml kg (-1) and 15 ml kg (-1) were tested in this study...
2017: F1000Research
https://www.readbyqxmd.com/read/28346813/protein-supplementation-does-not-affect-myogenic-adaptations-to-resistance-training
#20
Paul T Reidy, Christopher S Fry, Sherry Igbinigie, Rachel R Deer, Kristofer Jennings, Mark B Cope, Ratna Mukherjea, Elena Volpi, Blake B Rasmussen
It has been proposed that protein supplementation during resistance exercise training enhances muscle hypertrophy. The degree of hypertrophy during training is controlled in part through activation of satellite cells and myonuclear accretion. PURPOSE: To determine the efficacy of protein supplementation (and the type of protein) during traditional resistance training on myofiber cross-sectional-area, satellite cell content and myonuclear addition. METHODS: Healthy young men participated in supervised whole body progressive resistance training 3d/wk for 12 weeks...
February 14, 2017: Medicine and Science in Sports and Exercise
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