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https://www.readbyqxmd.com/read/27923233/efficacy-of-adipodren%C3%A2-in-reducing-interleukin-1-induced-lymphatic-endothelial-hyperpermeability
#1
Valerio Ciccone, Martina Monti, Giulia Antonini, Luisa Mattoli, Michela Burico, Francesca Marini, Anna Maidecchi, Lucia Morbidelli
Lymphatic leakage can be seen as a detrimental phenomenon associated with fluid retention and deposition as well as gain of weight. Moreover, lymphatic dysfunction is associated with an inflammatory environment and can be a substrate for other health conditions. A number of treatments can ameliorate lymphatic vasculature: natural substances have been used as treatment options particularly suitable for their consolidated effectiveness and safety profile. Here we report the protective effect of AdipoDren®, an association of a series of plant-derived natural complexes, on lymphatic endothelium permeability promoted by interleukin-1 beta (IL-1β) and the associated molecular mechanisms...
December 7, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27923231/congenital-absence-of-the-pericardium-a-systematic-approach-to-diagnosis-and-management
#2
Bo Xu, Jorge Betancor, Craig Asher, Adriana Rosario, Allan Klein
Congenital absence of the pericardium (CAP) is a rare condition. Failure to recognize the clinical features of this condition can lead to incorrect and delayed diagnosis. Limited data are available regarding the optimal approach to diagnose and manage patients with suspected CAP. Due to the rare nature of CAP, this condition can present diagnostic and management dilemmas for clinicians. Using 3 cases of CAP as a framework, a clinically focused review on the diagnosis and management of CAP is presented. Clinicians will be provided with a systematic approach to evaluating patients with suspected CAP, incorporating key history, examination, and multimodality cardiovascular imaging investigations...
December 7, 2016: Cardiology
https://www.readbyqxmd.com/read/27923219/nonoperative-versus-operative-treatment-of-displaced-ankle-fractures-in-diabetics
#3
Andrew J Lovy, James Dowdell, Aakash Keswani, Steven Koehler, Jaehon Kim, Steven Weinfeld, David Joseph
BACKGROUND: Diabetes is a risk factor for complications related to displaced ankle fractures. Limited literature exists comparing complication rates in nonoperative versus operative treatment of displaced ankle fractures in diabetics. No study has highlighted the natural history of nonoperative treatment of displaced ankle fractures in diabetics. METHODS: We retrospectively reviewed all adult ankle fractures from September 2011 through December 2014. Inclusion was limited to ambulatory adults (>18 years) with closed, displaced (widened mortise) ankle fractures with diabetes mellitus...
November 14, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27923173/electrophysiological-responses-to-symmetry-presented-in-the-left-or-in-the-right-visual-hemifield
#4
Damien Wright, Alexis D J Makin, Marco Bertamini
Symmetry is a highly salient feature in the visual world, abundant in both man-made and natural objects. In particular, humans find reflectional symmetry most salient. Electrophysiological work on symmetry perception has identified a difference wave known as the Sustained Posterior Negativity (SPN) originating from extrastriate areas. Amplitude is more negative for symmetrical than random patterns, from around 200 msec after stimulus onset. For the first time, we report responses to patterns presented exclusively in one hemifield...
November 10, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27923140/h2s-adsorption-onto-cu-zn-ni-nanoparticles-loaded-activated-carbon-and-ni-co-nanoparticles-loaded-%C3%AE-al2o3-optimization-and-adsorption-isotherms
#5
A Daneshyar, M Ghaedi, M M Sabzehmeidani, A Daneshyar
The nanocomposites based on copper, zinc and nickel were loaded on activated carbon (Cu-Zn-Ni-NPs-AC) and cobalt and nickel nanoparticles was loaded on γ-alumina (Ni-Co-NPs-γAl2O3) and applied for removal of hydrogen sulfide (H2S) from natural gas and their efficiency were compared. Cu-Zn-Ni/AC and Ni-Co/γ-Al2O3 was characterized using different techniques such as energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM). The effects of variables such as amount of adsorbent, flow rate, temperature, pressure and volume of gas on H2S removal were examined and optimum values were found to be 0...
November 21, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27923139/plga-peg-plga-triblock-copolymeric-micelles-as-oral-drug-delivery-system-in-vitro-drug-release-and-in-vivo-pharmacokinetics-assessment
#6
Xiufen Chen, Jianzhong Chen, Bowen Li, Xiang Yang, Rongjie Zeng, Yajun Liu, Tao Li, Rodney J Y Ho, Jingwei Shao
Poly (d,l-lactide-co-glycolide)-poly (ethylene glycol)-poly (d,l-lactide-co-glycolide) triblock copolymers (PLGA-PEG-PLGA) has been proven to be desirable for anti-cancer drug delivery by intravenous administration. But till now there is no report of developing this micelle as a sustained oral formulation for cancer therapy. 3β-acetoxy-urs-12-en-28-oic acid hexamethylenediamine (US597), a derivative of natural product ursolic acid has been developed as a novel cancer metastasis chemopreventive agent by us...
November 26, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27923122/natural-competence-for-transformation
#7
Melanie Blokesch
No abstract text is available yet for this article.
December 5, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27923110/impact-of-oligonucleotide-structure-chemistry-and-delivery-method-on-in-vitro-cytotoxicity
#8
Maja M Janas, Yongfeng Jiang, Mark K Schlegel, Scott Waldron, Satya Kuchimanchi, Scott A Barros
Single-stranded (ss) 2'-fluoro (2'-F)-modified oligonucleotides (ONs) with a full phosphorothioate (PS) backbone have been reported to be cytotoxic and cause DNA double-strand breaks (DSBs) when transfected into HeLa cells. However, the molecular determinants of these effects have not been fully explored. In this study, we investigated the impact of ON structure, chemistry, delivery method, and cell type on in vitro cytotoxicity and DSBs. We found that ss PS-ONs were more cytotoxic than double-stranded (ds) PS-ONs, irrespective of the 2'-ribose chemistry, inclusive of the 2'-F modification...
December 6, 2016: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/27923068/gene-expression-correlates-with-the-number-of-herpes-viral-genomes-initiating-infection-in-single-cells
#9
Efrat M Cohen, Oren Kobiler
Viral gene expression varies significantly among genetically identical cells. The sources of these variations are not well understood and have been suggested to involve both deterministic host differences and stochastic viral host interactions. For herpesviruses, only a limited number of incoming viral genomes initiate expression and replication in each infected cell. To elucidate the effect of this limited number of productively infecting genomes on viral gene expression in single cells, we constructed a set of fluorescence-expressing genetically tagged herpes recombinants...
December 6, 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27923060/the-limitations-of-model-based-experimental-design-and-parameter-estimation-in-sloppy-systems
#10
Andrew White, Malachi Tolman, Howard D Thames, Hubert Rodney Withers, Kathy A Mason, Mark K Transtrum
We explore the relationship among experimental design, parameter estimation, and systematic error in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many models of complex biological processes it is unknown what are the relevant physical mechanisms that must be included to explain system behaviors. As a consequence, models are often overly complex, with many practically unidentifiable parameters. Furthermore, which mechanisms are relevant/irrelevant vary among experiments...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27923039/natural-variation-in-arabidopsis-cvi-0-accession-reveals-an-important-role-of-mpk12-in-guard-cell-co2-signaling
#11
Liina Jakobson, Lauri Vaahtera, Kadri Tõldsepp, Maris Nuhkat, Cun Wang, Yuh-Shuh Wang, Hanna Hõrak, Ervin Valk, Priit Pechter, Yana Sindarovska, Jing Tang, Chuanlei Xiao, Yang Xu, Ulvi Gerst Talas, Alfonso T García-Sosa, Saijaliisa Kangasjärvi, Uko Maran, Maido Remm, M Rob G Roelfsema, Honghong Hu, Jaakko Kangasjärvi, Mart Loog, Julian I Schroeder, Hannes Kollist, Mikael Brosché
Plant gas exchange is regulated by guard cells that form stomatal pores. Stomatal adjustments are crucial for plant survival; they regulate uptake of CO2 for photosynthesis, loss of water, and entrance of air pollutants such as ozone. We mapped ozone hypersensitivity, more open stomata, and stomatal CO2-insensitivity phenotypes of the Arabidopsis thaliana accession Cvi-0 to a single amino acid substitution in MITOGEN-ACTIVATED PROTEIN (MAP) KINASE 12 (MPK12). In parallel, we showed that stomatal CO2-insensitivity phenotypes of a mutant cis (CO2-insensitive) were caused by a deletion of MPK12...
December 2016: PLoS Biology
https://www.readbyqxmd.com/read/27922998/hiring-and-retaining-home-care-nurses
#12
Leslie Jo Mitchell, Marilyn Oermann
Home care agencies are tasked with finding increasingly cost-efficient care processes to improve the quality of patient care outcomes. Hiring and retaining nurses who are well suited for home care are important factors that can influence the cost and provision of quality care in the home. The purpose of this article is to identify characteristics of home healthcare nurses that enable them to be successful home healthcare team members and leaders. A search of the literature was conducted to compile a list of questions with which to screen home healthcare nurse applicants for the required knowledge and skills as well as to improve retention rates of nurses hired...
January 2017: Home Healthcare Now
https://www.readbyqxmd.com/read/27922976/intraoperative-frozen-section-of-ovarian-tumors-a-6-year-review-of-performance-and-potential-pitfalls-in-an-australian-tertiary-referral-center
#13
Rhett Morton, Lyndal Anderson, Jonathan Carter, Selvan Pather, Samir A Saidi
OBJECTIVES: Intraoperative frozen section (IFS) offers a rapid test to guide the extent of surgery, which is essential for optimal treatment of ovarian cancer. This study evaluated the diagnostic performance and influence of IFS in the surgical management of ovarian tumors. METHODS: A retrospective review was conducted of IFS of adnexal lesions from 2008 to 2013, with diagnoses classified as benign, borderline, or malignant. The diagnostic performance of IFS was calculated, with a focus on primary epithelial tumors...
December 3, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27922920/communication-about-maternal-breast-cancer-with-children-a-qualitative-study
#14
Xiaoyan Huang, Margaret O'Connor, Yan Hu, Hongyun Gao, Susan Lee
BACKGROUND: Communication with children is a major concern for mothers with breast cancer. Chinese people have specific understanding of cancer and death, which may affect their way of communication. OBJECTIVE: The aim of this study is to explore how Chinese mothers with breast cancer communicate about their illness with their children. METHODS: An interpretive description study was conducted. Forty mothers with nonterminal breast cancer in mainland China were interviewed individually...
December 5, 2016: Cancer Nursing
https://www.readbyqxmd.com/read/27922898/clinical-hours-in-nurse-practitioner-programs-equals-clinical-competence-fact-or-misnomer
#15
Cathy R Fulton, Carol Clark, Stephanie Dickinson
An assumption in nursing education is that clinical experience equals competent practice. Knowing the extent of learning acquired during these experiences is important, and in graduate education, this is not always known. This study examined the nature of clinical hours that nurse practitioner students complete during practicum courses and explored activities of students when not engaged in direct patient care.
December 5, 2016: Nurse Educator
https://www.readbyqxmd.com/read/27922836/a-novel-method-for-full-locomotion-compensation-of-an-untethered-walking-insect
#16
Shunsuke Shigaki, Shunpei Fukushima, Daisuke Kurabayashi, Takeshi Sakurai, Ryohei Kanzaki
In this study, we developed a novel unfixed-type experimental system that we call a '3-DOF servosphere.' This system comprises one sphere and three omniwheels that support the sphere. The measurement method is very simple. An experimental animal is placed on top of the sphere. The position and heading angle of the animal are observed by using a high-speed camera installed above the sphere. Because the system can rotate the sphere with three degrees of freedom (DOFs) independently, the position and heading angle at the origin can be maintained without fixing the body...
December 6, 2016: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/27922828/a-new-method-of-estimation-of-dose-conversion-coefficients-for-aquatic-biota
#17
Yang Li, Jiangguo Li, Huijuan Wang, Aijun Wang
In order to develop the basis of an approach, through which we can comprehend the relationships of radiation exposures and dose, and dose and radiological effects, large numbers of dosimetric data are required. It is complex to estimate the dosimetry involved due to enormous variability of organism shapes, masses, and their natural habitats. This paper aims to develop an empirical equation, which correlates dose conversion coefficients (DCCs) with organism volume V, density ρ, source energy E and curve fitting coefficients...
December 6, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27922821/identification-of-salvia-haenkei-as-gerosuppressant-agent-by-using-an-integrated-senescence-screening-assay
#18
Ivana Matic, Ajinkya Revandkar, Jingjing Chen, Angela Bisio, Stefano Dall'Acqua, Veronica Cocetta, Paola Brun, Giorgio Mancino, Martina Milanese, Maurizio Mattei, Monica Montopoli, Andrea Alimonti
Cellular senescence is a stable cell cycle arrest that is the causative process of aging. The PI3K/AKT/mTOR pathway is implicated in the control of cellular senescence and inhibitors of this pathway have been successfully used for life span prolongation experiments in mammals. PTEN is the major regulator of the PI3K/AKT/mTOR pathway and loss of PTEN promotes a senescence response termed PICS. Here we report a novel-screening assay, for the identification of compounds that block different types of senescence response...
December 1, 2016: Aging
https://www.readbyqxmd.com/read/27922772/sarcina-ventriculi-review-of-the-literature
#19
Mohamed Rizwan Haroon Al Rasheed, Carmencita G Senseng
Sarcina ventriculi is an increasingly common gram-positive coccus, recognized in gastric biopsies, particularly of patients with delayed gastric emptying. It occurs most commonly in adult women and can be identified easily by its characteristic morphologic features, such as basophilic staining, cuboid shape, tetrad arrangement, red blood cell-sized packets, flattened cell walls, and refractile nature on light microscopy. Although the pathogenesis of the organism is debated, it has been implicated in cases of gastric perforation, emphysematous gastritis, and peritonitis as well as occurring in the background of gastric adenocarcinomas...
December 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27922770/on-the-nature-of-atypical-spitz-tumors
#20
Carmelo Urso
No abstract text is available yet for this article.
December 2016: Archives of Pathology & Laboratory Medicine
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