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https://www.readbyqxmd.com/read/28110458/experimental-evaluation-of-new-chitin-chitosan-graft-for-duraplasty
#1
M Pogorielov, A Kravtsova, G C Reilly, V Deineka, G Tetteh, O Kalinkevich, O Pogorielova, R Moskalenko, G Tkach
Natural materials such as collagen and alginate have promising applications as dural graft substitutes. These materials are able to restore the dural defect and create optimal conditions for the development of connective tissue at the site of injury. A promising material for biomedical applications is chitosan-a linear polysaccharide obtained by the deacetylation of chitin. It has been found to be nontoxic, biodegradable, biofunctional and biocompatible in addition to having antimicrobial characteristics. In this study we designed new chitin-chitosan substitutes for dura mater closure and evaluated their effectiveness and safety...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28110455/influence-of-environmental-and-anthropogenic-factors-at-the-bottom-sediments-in-a-doce-river-tributary-in-brazil
#2
Deyse Almeida Dos Reis, Aníbal da Fonseca Santiago, Laura Pereira Nascimento, Hubert Mathias Peter Roeser
In developing countries, it is uncommon to find watersheds that have been the object of detailed environmental studies. It makes the assessment of the magnitude of environmental impacts and pollution of these sites difficult. This research demonstrated ways to understand the dynamics of river bottom sediments contamination, even for watersheds with a lack of environmental data. Based on geochemical affinity, we conducted a comprehensive study on the concentration of metals and metalloids. Then, we discussed the probable origin of the concentration of these elements at the bottom sediment along the Matipó River...
January 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28110454/tackling-the-salinity-pollution-nexus-in-coastal-aquifers-from-arid-regions-using-nitrate-and-boron-isotopes
#3
V Re, E Sacchi
Salinization and nitrate pollution are generally ascertained as the main issues affecting coastal aquifers worldwide. In arid zones, where agricultural activities also result in soil salinization, both phenomena tend to co-exist and synergically contribute to alter groundwater quality, with severe negative impacts on human populations and natural ecosystems' wellbeing. It becomes therefore necessary to understand if and to what extent integrated hydrogeochemical tools can help in distinguishing among possible different salinization and nitrate contamination origins, in order to provide adequate science-based support to local development and environmental protection...
January 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28110421/dendritic-cell-immune-responses-in-hiv-1-controllers
#4
REVIEW
Enrique Martin-Gayo, Xu G Yu
PURPOSE OF REVIEW: Robust HIV-1-specific CD8 T cell responses are currently regarded as the main correlate of immune defense in rare individuals who achieve natural, drug-free control of HIV-1; however, the mechanisms that support evolution of such powerful immune responses are not well understood. Dendritic cells (DCs) are specialized innate immune cells critical for immune recognition, immune regulation, and immune induction, but their possible contribution to HIV-1 immune defense in controllers remains ill-defined...
January 21, 2017: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/28110362/adult-onset-intradural-spinal-teratoma-report-of-18-consecutive-cases-and-outcomes-in-a-single-center
#5
Wei Wan, Cheng Yang, Wangjun Yan, Tielong Liu, Xinghai Yang, Dianwen Song, Jianru Xiao
STUDY DESIGN: Eighteen consecutive patients with adult-onset intradural spinal teratoma underwent surgical treatment in our center from 1998 to 2013. BACKGROUND AND PURPOSE: Teratoma is defined as a neoplasm composed of elements derived from three germ cell layers (ectoderm, endoderm and mesoderm). Intraspinal teratoma is extremely rare and accounts for 0.2-0.5% of all spinal cord tumors. Moreover, teratoma occurs primarily in neonates and young children. Adult-onset intradural spinal teratoma is even rare...
January 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28110358/pollution-assessment-of-the-biob%C3%A3-o-river-chile-prioritization-of-substances-of-concern-under-an-ecotoxicological-approach
#6
Álvaro Alonso, Ricardo Figueroa, Pilar Castro-Díez
The water demand for human activities is rapidly increasing in developing countries. Under these circumstances, preserving aquatic ecosystems should be a priority which requires the development of quality criteria. In this study we perform a preliminary prioritization of the risky substances based on reported ecotoxicological studies and guidelines for the Biobío watershed (Central Chile). Our specific aims are (1) reviewing the scientific information on the aquatic pollution of this watershed, (2) determining the presence and concentration of potential toxic substances in water, sediment and effluents, (3) searching for quality criteria developed by other countries for the selected substances and (4) prioritizing the most risky substances by means of deterministic ecotoxicological risk assessment...
January 21, 2017: Environmental Management
https://www.readbyqxmd.com/read/28110357/the-potential-role-of-tree-diversity-in-reducing-shallow-landslide-risk
#7
Yuta Kobayashi, Akira S Mori
Recently, interest in utilizing ecosystems for disaster risk reduction has increased, even though there remains considerable uncertainty regarding the role of ecosystems in buffering against natural hazards. This ecosystem role can be considered an ecosystem service. Although a strong body of evidence shows that biodiversity enhances ecosystem services, there are only a few studies of the relationship between biodiversity and the role of the ecosystem in reducing the risk of natural disasters. To explore the desired state of an ecosystem for disaster risk reduction we applied the finding that biodiversity enhances ecosystem services to evaluate the role of woody vegetation in reducing the frequency and severity of shallow landslides...
January 21, 2017: Environmental Management
https://www.readbyqxmd.com/read/28110326/behavioural-responses-of-yunnan-snub-nosed-monkeys-rhinopithecus-bieti-to-tourists-in-a-provisioned-monkey-group-in-baimaxueshan-nature-reserve
#8
Wancai Xia, Baoping Ren, Yanhong Li, Jie Hu, Xinming He, Ali Krzton, Ming Li, Dayong Li
The appearance of tourists brings about behavioural changes in some primates. Primate behavioural responses to human activities can reflect their survival strategy. Little is known about how the behaviour of Rhinopithecus bieti changes in the presence of tourists. Here we provide the first detailed description of interactions between a provisioned group of R. bieti and tourists at Xiangguqing in Baimaxueshan Nature Reserve from July 2012 to June 2013. We found that R. bieti had different response rates to the 5 most common human actions (shout, photograph, offer food, clap, and wave)...
January 21, 2017: Folia Primatologica; International Journal of Primatology
https://www.readbyqxmd.com/read/28110279/walking-the-c4-pathway-past-present-and-future
#9
REVIEW
Robert T Furbank
The year 2016 marks 50 years since the publication of the seminal paper by Hatch and Slack describing the biochemical pathway we now know as C4 photosynthesis. This review provides insight into the initial discovery of this pathway, the clues which led Hatch and Slack and others to these definitive experiments, some of the intrigue which surrounds the international activities which led up to the discovery, and personal insights into the future of this research field. While the biochemical understanding of the basic pathways came quickly, the role of the bundle sheath intermediate CO2 pool was not understood for a number of years, and the nature of C4 as a biochemical CO2 pump then linked the unique Kranz anatomy of C4 plants to their biochemical specialization...
January 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28110278/a-portrait-of-the-c4-photosynthetic-family-on-the-50th-anniversary-of-its-discovery-species-number-evolutionary-lineages-and-hall-of-fame
#10
REVIEW
Rowan F Sage
Fifty years ago, the C4 photosynthetic pathway was first characterized. In the subsequent five decades, much has been learned about C4 plants, such that it is now possible to place nearly all C4 species into their respective evolutionary lineages. Sixty-one independent lineages of C4 photosynthesis are identified, with additional, ancillary C4 origins possible in 12 of these principal lineages. The lineages produced ~8100 C4 species (5044 grasses, 1322 sedges, and 1777 eudicots). Using midpoints of stem and crown node dates in their respective phylogenies, the oldest and most speciose C4 lineage is the grass lineage Chloridoideae, estimated to be near 30 million years old...
January 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28110275/traces-of-strong-selective-pressures-in-the-genomes-of-c4-grasses
#11
Pascal-Antoine Christin
C4 photosynthesis is nature's response to CO2 limitations, and evolved recurrently in several groups of plants. To identify genes related to C4 photosynthesis, Huang et al. looked for evidence of past episodes of adaptive evolution in the genomes of C4 grasses. They identified a large number of candidate genes that evolved under divergent selection, indicating that, besides alterations to expression patterns, the history of C4 involved strong selection on protein-coding sequences.
January 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28110272/mitonuclear-interactions-mediate-transcriptional-responses-to-hypoxia-in-drosophila
#12
Jim A Mossman, Jennifer G Tross, Nick A Jourjine, Nan Li, Zhijin Wu, David M Rand
Among the major challenges in quantitative genetics and personalized medicine is to understand how gene × gene interactions (G × G: epistasis) and gene × environment interactions (G × E) underlie phenotypic variation. Here, we use the intimate relationship between mitochondria and oxygen availability to dissect the roles of nuclear DNA (nDNA) variation, mitochondrial DNA (mtDNA) variation, hypoxia, and their interactions on gene expression in Drosophila melanogaster Mitochondria provide an important evolutionary and medical context for understanding G × G and G × E given their central role in integrating cellular signals...
November 14, 2016: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28110224/emotional-intelligence-and-coping-strategies-as-determinants-of-quality-of-life-in-depressed-patient-caregiver-dyads-an-actor-partner-interdependence-analysis
#13
L Boyer, K Baumstarck, M Alessandrini, Z Hamidou, J Testart, M Serres, P Arquillière, P Auquier, T Leroy, X Zendjidjian
OBJECTIVE: Patients with major depressive disorder (MDD) and their natural caregivers experience major lifestyle difficulties. Little is known concerning dyadic (i.e., patient and natural caregiver) characteristics' impact on quality of life. In a sample of depressed patient-caregiver dyads, we examined quality of life (QoL) levels compared with the general population and whether QoL is influenced by emotional intelligence (EI) and coping strategies using the actor-partner interdependence model (APIM)...
January 8, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28110223/guilt-without-fault-a-qualitative-study-into-the-ethics-of-forgiveness-after-traumatic-childbirth
#14
Katja Schrøder, Karen la Cour, Jan Stener Jørgensen, Ronald F Lamont, Niels Christian Hvidt
When a life is lost or severely impaired during childbirth, the midwife and obstetrician involved may experience feelings of guilt in the aftermath. Through three empirical cases, the paper examines the sense of guilt in the context of the current patient safety culture in healthcare where a blame-free approach is promoted in the aftermath of adverse events. The purpose is to illustrate how healthcare professionals may experience guilt without being at fault after adverse events, and Gamlund's theory on forgiveness without blame is used as the theoretical framework for this analysis...
January 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28110191/asiatic-acid-enhances-nrf2-signaling-to-protect-hepg2-cells-from-oxidative-damage-through-akt-and-erk-activation
#15
Zhimin Qi, Xinxin Ci, Jingbo Huang, Qinmei Liu, Qinlei Yu, Junfeng Zhou, Xuming Deng
Asiatic acid (AA), a natural triterpene isolated from the plant Centella asiatica, have antioxidative potential, but the molecular mechanism of AA against oxidative stress remains unclear. Our study was performed to investigate the antioxidative effect of AA against oxidative stress and the antioxidative mechanism in tert-butyl hydroperoxide (t-BHP) -stimulated the HepG2 cells. The results showed that AA suppressed t-BHP-induced cytotoxicity, apoptosis, and reactive oxygen species (ROS) generation. Additionally, AA activated the nuclear factor erythroid 2-related factor 2 (Nrf2) signal, which was closely related to induction Nrf2 nuclear translocation, reduction the expression of Keap1 and up-regulation the activity of the antioxidant response element (ARE)...
January 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28110189/anticancer-activity-of-baicalein-and-luteolin-studied-in-colorectal-adenocarcinoma-lovo-cells-and-in-drug-resistant-lovo-dx-cells
#16
Anna Palko-Labuz, Kamila Sroda-Pomianek, Anna Uryga, Edyta Kostrzewa-Suslow, Krystyna Michalak
Due to the type-specific diversity of cancer cells, an analysis and elucidation of molecular mechanisms responsible for anticancer properties of biologically active compounds are essential. Plant-derived polyphenolic compounds such as flavonoids may be useful in cancer chemoprevention or treatment because they influence diverse molecular pathways in cancer cells. In these studies anticancer activity of natural occurring flavones, baicalein and luteolin was investigated in colon cancer cells LoVo and in their drug resistant subline LoVo/Dx...
January 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28110183/noncovalent-interaction-assisted-fullerene-for-the-transportation-of-some-brain-anticancer-drugs-a-theoretical-study
#17
Pabitra Narayan Samanta, Kalyan Kumar Das
The treatment of brain cancer like glioblastoma multiforme often uses chemotherapeutic drugs like temozolomide, procarbazine, carmustine, and lomustine. Fullerene loaded with these drugs help to cross the blood brain barriers. The adsorptions of the four drug molecules on the surface of the fullerene are studied mostly by using density functional theory (DFT) based method at the M06-2X/6-31G(d) level of calculations. In all four cases, the estimated interactions are noncovalent type and the average adsorption energy lies in between -5 and -11kcal/mol in the gas phase...
January 8, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28110152/is-the-bias-for-function-based-explanations-culturally-universal-children-from-china-endorse-teleological-explanations-of-natural-phenomena
#18
Adena Schachner, Liqi Zhu, Jing Li, Deborah Kelemen
Young children in Western cultures tend to endorse teleological (function-based) explanations broadly across many domains, even when scientifically unwarranted. For instance, in contrast to Western adults, they explicitly endorse the idea that mountains were created for climbing, just like hats were created for warmth. Is this bias a product of culture or a product of universal aspects of human cognition? In two studies, we explored whether adults and children in Mainland China, a highly secular, non-Western culture, show a bias for teleological explanations...
January 19, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28110150/enhanced-degradation-of-iopamidol-by-peroxymonosulfate-catalyzed-by-two-pipe-corrosion-products-cuo-and-%C3%AE-mno2
#19
Jun Hu, Huiyu Dong, Jiuhui Qu, Zhimin Qiang
Peroxymonosulfate (PMS) is a promising alternative for drinking water disinfection; also many organic micropollutants may be present in drinking water sources nowadays. However, pipe corrosion products (PCPs) may impact the reactions between a disinfectant and organic micropollutants in water distribution systems. This study investigated iopamidol (IPM) degradation by PMS under catalysis of two PCPs (i.e., CuO and δ-MnO2). The pseudo-first-order rate constant of IPM degradation in the CuO/PMS system (CuPS) was 3...
January 16, 2017: Water Research
https://www.readbyqxmd.com/read/28110114/tropoelastin-coated-plla-plga-scaffolds-promote-vascular-network-formation
#20
Shira Landau, Ariel A Szklanny, Giselle C Yeo, Yulia Shandalov, Elena Kosobrodova, Anthony S Weiss, Shulamit Levenberg
The robust repair of large wounds and tissue defects relies on blood flow. This vascularization is the major challenge faced by tissue engineering on the path to forming thick, implantable tissue constructs. Without this vasculature, oxygen and nutrients cannot reach the cells located far from host blood vessels. To make viable constructs, tissue engineering takes advantage of the mechanical properties of synthetic materials, while combining them with ECM proteins to create a natural environment for the tissue-specific cells...
January 11, 2017: Biomaterials
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