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https://www.readbyqxmd.com/read/28212584/hyaluronic-acid-serum-albumin-conjugate-based-nanoparticles-for-targeted-cancer-therapy
#1
Ravit Edelman, Yehuda G Assaraf, Inna Levitzky, Tal Shahar, Yoav D Livney
Multiple carcinomas including breast, ovarian, colon, lung and stomach cancer, overexpress the hyaluronic acid (HA) receptor, CD44. Overexpression of CD44 contributes to key cancer processes including tumor invasion, metastasis, recurrence, and chemoresistance. Herein, we devised novel targeted nanoparticles (NPs) for delivery of anticancer chemotherapeutics, comprised of self-assembling Maillard reaction-based conjugates of HA and bovine serum albumin (BSA). HA served as the hydrophilic block, and as the ligand for actively targeting cancer cells overexpressing CD44...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212547/resveratrol-induces-cell-cycle-arrest-and-apoptosis-with-docetaxel-in-prostate-cancer-cells-via-a-p53-p21waf1-cip1-and-p27kip1-pathway
#2
Santosh Kumar Singh, Saswati Banerjee, Edward P Acosta, James W Lillard, Rajesh Singh
Resveratrol (RES) is the most effective natural products used for the treatment of a variety of cancers. In this study, we tested the effect of RES in enhancing the efficacy of docetaxel (DTX) treatment in prostate cancer (PCa) cells. The C4-2B and DU-145 cell lines were treated with RES, DTX and combination followed by evaluating the apoptosis and cell cycle progression. The combined drug treatment up-regulates the pro-apoptotic genes (BAX, BID, and BAK), cleaved PARP and down regulates the anti-apoptotic genes (MCL-1, BCL-2, BCL-XL) promoting apoptosis...
February 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212522/taking-up-the-cudgels-for-the-traditional-reactive-oxygen-and-nitrogen-species-detection-assays-and-their-use-in-the-cardiovascular-system
#3
REVIEW
Andreas Daiber, Matthias Oelze, Sebastian Steven, Swenja Kröller-Schön, Thomas Münzel
Reactive oxygen and nitrogen species (RONS such as H2O2, nitric oxide) confer redox regulation of essential cellular functions (e.g. differentiation, proliferation, migration, apoptosis), initiate and catalyze adaptive stress responses. In contrast, excessive formation of RONS caused by impaired break-down by cellular antioxidant systems and/or insufficient repair of the resulting oxidative damage of biomolecules may lead to appreciable impairment of cellular function and in the worst case to cell death, organ dysfunction and severe disease phenotypes of the entire organism...
February 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/28212506/dimensional-and-discrete-variations-on-the-psychosis-continuum-in-a-dutch-crowd-sourcing-population-sample
#4
J T W Wigman, K J Wardenaar, R B K Wanders, S H Booij, B F Jeronimus, L van der Krieke, M Wichers, P de Jonge
BACKGROUND: Mild psychotic experiences are common in the general population. Although transient and benign in most cases, these experiences are predictive of later mental health problems for a significant minority. The goal of the present study was to perform examinations of the dimensional and discrete variations in individuals' reporting of subclinical positive and negative psychotic experiences in a unique Dutch internet-based sample from the general population. METHODS: Positive and negative subclinical psychotic experiences were measured with the Community Assessment of Psychic Experiences in 2870 individuals...
December 18, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28212503/lactobacillus-buchneri-s-layer-as-carrier-for-an-ara-h-2-derived-peptide-for-peanut-allergen-specific-immunotherapy
#5
Julia Anzengruber, Merima Bublin, Eva Bönisch, Bettina Janesch, Angelika Tscheppe, Matthias L Braun, Eva-Maria Varga, Christine Hafner, Heimo Breiteneder, Christina Schäffer
Peanut allergy is an IgE-mediated severe hypersensitivity disorder. The lack of a treatment of this potentially fatal allergy has led to intensive research on vaccine development. Here, we describe the design and initial characterization of a carrier-bound peptide derived from the most potent peanut allergen, Ara h 2, as a candidate vaccine. Based on the adjuvant capability of bacterial surface (S-) layers, a fusion protein of the S-layer protein SlpB from Lactobacillus buchneri CD034 and the Ara h 2-derived peptide AH3a42 was produced...
February 14, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28212486/highly-efficient-and-anomalous-charge-transfer-in-van-der-waals-trilayer-semiconductors
#6
Frank Ceballos, Ming-Gang Ju, Samuel D Lane, Xiao Cheng Zeng, Hui Zhao
Two dimensional materials, such as graphene and monolayer transition metal dichalcogenides, allow the fabrication of multilayer structures without lattice matching restriction. A central issue in developing such artificial materials is to understand and control the interlayer electron transfer process, which plays a key role in harvesting their emergent properties. Recent photoluminescence and transient absorption measurements revealed that the electron transfer in hetero-bilayers occurs on ultrafast time scales...
February 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28212464/oxytocin-reduces-ethanol-self-administration-in-mice
#7
Courtney E King, William C Griffin, Lauryn N Luderman, Malcolm M Kates, Jacqueline F McGinty, Howard C Becker
BACKGROUND: Excessive ethanol consumption remains an important health concern and effective treatments are lacking. The central oxytocin system has emerged as a potentially important therapeutic target for alcohol and drug addiction. These studies tested the hypothesis that oxytocin reduces ethanol consumption. METHODS: Male C57BL/6J mice were given access to ethanol (20% v/v) using a model of binge-like drinking ("drinking-in-the-dark") that also included the use of lickometer circuits to evaluate the temporal pattern of intake as well as 2-bottle choice drinking in the home cage...
February 17, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28212458/chemical-composition-variability-of-essential-oils-of-daucus-gracilis-steinh-from-algeria
#8
Batoul Benyelles, Hocine Allali, Mohamed El Amine Dib, Nassim Djabou, Julien Paolini, Jean Costa
The chemical compositions of 20 Algerian Daucus gracilis essential oils were investigated using GC-FID, GC/MS, and NMR analyses. Altogether, 47 compounds were identified, accounting for 90-99% of the total oil compositions. The main components were linalool (18; 12.5-22.6%), 2-methylbutyl 2-methylbutyrate (20; 9.2-20.2%), 2-methylbutyl isobutyrate (10; 4.2-12.2%), ammimajane (47; 2.6-37.1%), (E)-β-ocimene (15; 0.2-12.8%) and 3-methylbutyl isovalerate (19; 3.3-9.6%). The chemical composition of the essential oils obtained from separate organs was also studied...
February 17, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28212437/the-nature-of-allometry-in-an-exaggerated-trait-the-postocular-flange-in-platyneuromus-weele-insecta-megaloptera
#9
Andrés Ramírez-Ponce, Gabriela Garfias-Lozano, Atilano Contreras-Ramos
The origin and function of exaggerated traits exhibited by a great number of species with sexual dimorphism remain largely unexplored. The usual model considered as the evolutionary mechanism for the development of these structures is sexual selection. The nature of growth of the postocular flange (POF) in three species of the dobsonfly genus Platyneuromus (Megaloptera, Corydalidae, Corydalinae) is analyzed to explore sexual size dimorphism and allometric scaling. Results involve positive allometry of POF in males of two species, and negative allometry in males of one species, in general with a female-biased sexual dimorphism...
2017: PloS One
https://www.readbyqxmd.com/read/28212426/sustainability-of-common-pool-resources
#10
Raja Rajendra Timilsina, Koji Kotani, Yoshio Kamijo
Sustainability has become a key issue in managing natural resources together with growing concerns for capitalism, environmental and resource problems. We hypothesize that the ongoing modernization of competitive societies, which we refer to as "capitalism," affects human nature for utilizing common pool resources, thus compromising sustainability. To test this hypothesis, we design and implement a set of dynamic common pool resource games and experiments in the following two types of Nepalese areas: (i) rural (non-capitalistic) and (ii) urban (capitalistic) areas...
2017: PloS One
https://www.readbyqxmd.com/read/28212423/phenolic-extract-from-oleaster-olea-europaea-var-sylvestris-leaves-reduces-colon-cancer-growth-and-induces-caspase-dependent-apoptosis-in-colon-cancer-cells-via-the-mitochondrial-apoptotic-pathway
#11
Wafa Zeriouh, Abdelhafid Nani, Meriem Belarbi, Adélie Dumont, Charlotte de Rosny, Ikram Aboura, Fatima Zahra Ghanemi, Babar Murtaza, Danish Patoli, Charles Thomas, Lionel Apetoh, Cédric Rébé, Dominique Delmas, Naim Akhtar Khan, François Ghiringhelli, Mickael Rialland, Aziz Hichami
Dietary polyphenols, derived from natural products, have received a great interest for their chemopreventive properties against cancer. In this study, we investigated the effects of phenolic extract of the oleaster leaves (PEOL) on tumor growth in mouse model and on cell death in colon cancer cell lines. We assessed the effect of oleaster leaf infusion on HCT116 (human colon cancer cell line) xenograft growth in athymic nude mice. We observed that oleaster leaf polyphenol-rich infusion limited HCT116 tumor growth in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28212416/the-variability-of-multisensory-processes-of-natural-stimuli-in-human-and-non-human-primates-in-a-detection-task
#12
Cécile Juan, Céline Cappe, Baptiste Alric, Benoit Roby, Sophie Gilardeau, Pascal Barone, Pascal Girard
BACKGROUND: Behavioral studies in both human and animals generally converge to the dogma that multisensory integration improves reaction times (RTs) in comparison to unimodal stimulation. These multisensory effects depend on diverse conditions among which the most studied were the spatial and temporal congruences. Further, most of the studies are using relatively simple stimuli while in everyday life, we are confronted to a large variety of complex stimulations constantly changing our attentional focus over time, a modality switch that can impact on stimuli detection...
2017: PloS One
https://www.readbyqxmd.com/read/28212412/a-mathematical-model-of-aortic-aneurysm-formation
#13
Wenrui Hao, Shihua Gong, Shuonan Wu, Jinchao Xu, Michael R Go, Avner Friedman, Dai Zhu
Abdominal aortic aneurysm (AAA) is a localized enlargement of the abdominal aorta, such that the diameter exceeds 3 cm. The natural history of AAA is progressive growth leading to rupture, an event that carries up to 90% risk of mortality. Hence there is a need to predict the growth of the diameter of the aorta based on the diameter of a patient's aneurysm at initial screening and aided by non-invasive biomarkers. IL-6 is overexpressed in AAA and was suggested as a prognostic marker for the risk in AAA. The present paper develops a mathematical model which relates the growth of the abdominal aorta to the serum concentration of IL-6...
2017: PloS One
https://www.readbyqxmd.com/read/28212399/instrument-design-and-protocol-for-the-study-of-light-controlled-processes-in-aquatic-organisms-and-its-application-to-examine-the-effect-of-infrared-light-on-zebrafish
#14
Marcus P S Dekens, Nicholas S Foulkes, Kristin Tessmar-Raible
The acquisition of reliable data strongly depends on experimental design. When studying the effects of light on processes such as behaviour and physiology it is crucial to maintain all environmental conditions constant apart from the one under study. Furthermore, the precise values of the environmental factors applied during the experiment should be known. Although seemingly obvious, these conditions are often not met when the effects of light are being studied. Here, we document and discuss the wavelengths and light intensities of natural and artificial light sources...
2017: PloS One
https://www.readbyqxmd.com/read/28212384/global-economic-impacts-of-climate-variability-and-change-during-the-20th-century
#15
Francisco Estrada, Richard S J Tol, Wouter J W Botzen
Estimates of the global economic impacts of observed climate change during the 20th century obtained by applying five impact functions of different integrated assessment models (IAMs) are separated into their main natural and anthropogenic components. The estimates of the costs that can be attributed to natural variability factors and to the anthropogenic intervention with the climate system in general tend to show that: 1) during the first half of the century, the amplitude of the impacts associated with natural variability is considerably larger than that produced by anthropogenic factors and the effects of natural variability fluctuated between being negative and positive...
2017: PloS One
https://www.readbyqxmd.com/read/28212342/a-review-on-the-phytochemistry-pharmacology-and-pharmacokinetics-of-amentoflavone-a-naturally-occurring-biflavonoid
#16
REVIEW
Sheng Yu, Hui Yan, Li Zhang, Mingqiu Shan, Peidong Chen, Anwei Ding, Sam Fong Yau Li
Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence effects on many important reactions in the cardiovascular and central nervous system, etc. Over 120 plants have been found to contain this bioactive component, such as Selaginellaceae, Cupressaceae, Euphorbiaceae, Podocarpaceae, and Calophyllaceae plant families...
February 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28212341/physicochemical-characterization-and-biological-activities-of-the-triterpenic-mixture-%C3%AE-%C3%AE-amyrenone
#17
Rosilene G S Ferreira, Walter F Silva Júnior, Valdir F Veiga Junior, Ádley A N Lima, Emerson S Lima
α-Amyrenone and β-amyrenone are triterpenoid isomers that occur naturally in very low concentrations in several oleoresins from Brazilian Amazon species of Protium (Burseraceae). This mixture can also be synthesized by oxidation of α,β-amyrins, obtained as major compounds from the same oleoresins. Using a very simple, high yield procedure, and using a readily commercially available mixture of α,β-amyrins as substrate, the binary compound α,β-amyrenone was synthesized and submitted to physico-chemical characterization using different techniques such as high-performance liquid chromatography, nuclear magnetic resonance (¹H and (13)C), mass spectrometry, scanning electron microscopy, differential scanning calorimetry, thermogravimetry and derivative thermogravimetry, and Fourier transform infrared spectroscopy (FTIR)...
February 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28212330/synthesis-of-8-aryl-o-methylcyanidins-and-their-usage-for-dye-sensitized-solar-cell-devices
#18
Yuki Kimura, Kin-Ichi Oyama, Yasujiro Murata, Atsushi Wakamiya, Kumi Yoshida
Anthocyanins as natural pigments are colorful and environmentally compatible dyes for dye-sensitized solar cells (DSSCs). To increase the efficiency, we designed and synthesized unnatural O-methylflavonols and O-methylcyanidins that possess an aryl group at the 8-position. We synthesized per-O-methylquercetin from quercetin, then using selective demethylation prepared various O-methylquercetins. Using the Suzuki-Miyaura coupling reaction, 8-arylation of per-O-methylquercetin was achieved. Using a LiAlH₄ reduction or Clemmensen reduction, these flavonols were transformed to the corresponding cyanidin derivatives in satisfactory yields...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28212297/inorganic-reactive-sulfur-nitrogen-species-intricate-release-mechanisms-or-cacophony-in-yellow-blue-and-red
#19
Marian Grman, Muhammad Jawad Nasim, Roman Leontiev, Anton Misak, Veronika Jakusova, Karol Ondrias, Claus Jacob
Since the heydays of Reactive Sulfur Species (RSS) research during the first decade of the Millennium, numerous sulfur species involved in cellular regulation and signalling have been discovered. Yet despite the general predominance of organic species in organisms, recent years have also seen the emergence of inorganic reactive sulfur species, ranging from inorganic polysulfides (HSx(-)/Sx(2-)) to thionitrous acid (HSNO) and nitrosopersulfide (SSNO(-)). These inorganic species engage in a complex interplay of reactions in vitro and possibly also in vivo...
February 15, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28212295/short-chain-chitin-oligomers-promoters-of-plant-growth
#20
Alexander J Winkler, Jose Alfonso Dominguez-Nuñez, Inmaculada Aranaz, César Poza-Carrión, Katrina Ramonell, Shauna Somerville, Marta Berrocal-Lobo
Chitin is the second most abundant biopolymer in nature after cellulose, and it forms an integral part of insect exoskeletons, crustacean shells, krill and the cell walls of fungal spores, where it is present as a high-molecular-weight molecule. In this study, we showed that a chitin oligosaccharide of lower molecular weight (tetramer) induced genes in Arabidopsis that are principally related to vegetative growth, development and carbon and nitrogen metabolism. Based on plant responses to this chitin tetramer, a low-molecular-weight chitin mix (CHL) enriched to 92% with dimers (2mer), trimers (3mer) and tetramers (4mer) was produced for potential use in biotechnological processes...
February 15, 2017: Marine Drugs
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