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https://www.readbyqxmd.com/read/28454485/cheminformatics-based-anticoagulant-study-of-traditionally-used-medicinal-plants
#1
Mahdi Alikhani Pour, Soroush Sardari, Ali Eslamifar, Abid Azhar, Mohammad Rezvani, Milad Nazari
Backgroung: Medicinal plants, as a complementary medicine, have been used to treat various diseases since ancient times. These plants have numerous beneficial applications and are the source of certain conventional drugs. In diseases such as stroke and ischemia, which are caused by several factors, abnormal coagulation is an important causative factor. Accordingly, novel and effective therapies such as herbal remedies should be practiced to prevent such lethal diseases. Methods: Using the available databases such as Google Scholar and PubMed, the previously reported anticoagulant compounds and plants possessing anticoagulant activity were identified and collected in two separate lists...
April 29, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28454468/ethanolic-extract-of-thevetia-peruviana-flowers-enhances-tnf-%C3%AE-and-trail-induced-apoptosis-of-human-cervical-cancer-cells-via-intrinsic-and-extrinsic-pathways
#2
Chittima Managit, Hiroaki Sakurai, Ikuo Saiki
Tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing ligand (TRAIL) are promising candidates for cancer treatment due to their ability to induce apoptosis through death receptor stimulation. However, their usage may be limited due to the resistance of cancer cells to TNF-α- and TRAIL-induced apoptosis. Currently, there is interest in screening for natural products that can sensitize cancer cells to TNF-α- and TRAIL-induced apoptosis for their use in combination with TNF-α or TRAIL. It was previously reported that the bark extract of Thevetia peruviana showed a reversal effect on TRAIL-resistance in human gastric adenocarcinoma cell lines...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454464/metastasis-from-a-primary-hepatic-angiosarcoma-to-the-colon-a-case-report-and-literature-review
#3
Yukako Mokutani, Taishi Hata, Yuichiro Miyake, Hideki Kuroda, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
Primary hepatic angiosarcoma is a rare type of tumor with a poor prognosis. To the best of our knowledge, curative surgery of a metastatic gastrointestinal angiosarcoma from a hepatic angiosarcoma has not been reported previously. In the present report, a case of colonic metastasis from a primary hepatic angiosarcoma is discussed. A rapidly growing mass was identified in the liver of an 84-year-old Japanese male who underwent a subsegmentectomy of the liver. Microscopic examination determined that the mass was an angiosarcoma composed of sheets of spindle cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454338/ellagic-acid-and-annona-muricata-in-the-chemoprevention-of-hpv-related-pre-neoplastic-lesions-of-the-cervix
#4
Giulia Morosetti, Anna Angela Criscuolo, Flavia Santi, Carlo Federico Perno, Emilio Piccione, Marco Ciotti
Ellagic acid is a phenolic compound naturally present in nuts and berries. Several studies have demonstrated that this bioactive compound has antioxidant, chemopreventive and antiviral activity. Annona muricata is a type of fruit tree with a long history of traditional use. A number of properties have been attributed to different parts of the plant, including anticancer and antioxidant activities. In the current study, a complex based on ellagic acid, Annona Muricata and antioxidant factors (an ellagic acid complex) was administered to a group of human papilloma virus (HPV) infected women with and without cervical lesions, for 12 months...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454308/longikaurin-a-a-natural-ent-kaurane-suppresses-stemness-in-nasopharyngeal-carcinoma-cells
#5
Yan Yuan, Yong Du, Xiao-Ye Hu, Mei-Yuan Liu, Ji-Ke Du, Xue-Min Liu, Hong-En Yu, Tian-Zhu Wang, Jian-Xin Pu, Qian Zhong, Qing-Feng Zou
Cancer stem cells (CSCs) are a small proportion of tumor cells that may be responsible for tumor metastasis and recurrence. Our recent research indicated that longikaurin A (LK-A) exhibited anti-tumor activity in nasopharyngeal carcinoma (NPC) both in vitro and in vivo. Here, we further investigated whether LK-A could suppress the stemness of NPC cells. Sphere formation assay was used to assess the self-renewal ability of the cells treated with LK-A. Side population (SP) was determined by flow cytometry to measure the influence of LK-A on NPC SPs...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454283/targeting-of-growth-factors-in-the-treatment-of-hepatocellular-carcinoma-the-potentials-of-polysaccharides
#6
Xuan Wang, Jieyu Ding, Yuanyuan Feng, Lingling Weng, Guangqiang Zhao, Jianfeng Xiang, Minguang Zhang, Dongwei Xing
Hepatocellular carcinoma (HCC) has become a leading cause of cancer-associated mortality worldwide and is thus of great concern. Although various chemotherapeutic drugs are currently used for the treatment of HCC, severe side effects associated with these treatments have prompted interest in novel therapies, including the use of certain biological macromolecules such as polysaccharides. Several studies have shown that polysaccharides have anticancer and antiproliferative effects on HCC. Vascular endothelial growth factor, transforming growth factor β, epidermal growth factor and fibroblast growth factor may be effective targets for polysaccharides and may modulate tumor growth and immunity through increasing the expression levels of cytokines...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454257/sarcomatoid-urothelial-carcinoma-with-chondrosarcomatous-differentiation-of-the-ureter-a-case-report-and-review-of-the-literature
#7
Wei Lu, Yanjun Wang, Yonghong Li, Yun Cao, Hui Han, Fangjian Zhou
Sarcomatoid urothelial carcinoma of the urinary tract is associated with poor prognosis. The majority of sarcomatoid urothelial carcinomas are found in the urinary bladder, while a small minority have been shown to arise from the ureter. In the present case, a 72-year-old male patient was diagnosed with sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the left ureter, and subsequently underwent nephroureterectomy and retroperitoneal lymph node dissection. Two lymph nodes from the renal hilum and one paraaortic lymph node were also found to have metastatic involvement; however, the patient refused to receive chemotherapy or radiotherapy and succumbed to bone and omentum metastasis at 6 months after the initial diagnosis...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454242/association-of-elevated-risk-of-pancreatic-cancer-in-diabetic-patients-a-systematic-review-and-meta-analysis
#8
Jiaxin Tan, Yu You, Fei Guo, Jianhua Xu, Haisu Dai, Ping Bie
Pancreatic cancer has a five-year overall survival rate <5%, a situation that has not improved since for 40 years. Diabetes mellitus including type 2 diabetes mellitus (T2D) is a suspected risk factor for the development of pancreatic cancer and nearly 45% of the pancreatic cancer cases are likely to present as new onset diabetes cases; however, the nature of association between T2D and pancreatic cancer is still controversial. In this meta-analysis, we examined the association specifically of T2D with pancreatic cancer and the influence of insulin therapy...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454236/prognostic-significance-of-cd30-expression-in-nasal-natural-killer-t-cell-lymphoma
#9
Guan-Nan Wang, Wu-Gan Zhao, Ling Li, Dan-Dan Zhang, Xian-Zheng Gao, Jun Zhou, Lei Zhang, Xiao-Rui Fu, Xiang-Yu Zheng, Ye Li, Zhen Li, Ming-Zhi Zhang, Wen-Cai Li
The present study aimed to investigate the expression of tumor necrosis factor receptor superfamily member 8 (CD30) in extranodal natural killer/T-cell lymphoma (ENKTL) using immunohistochemistry, and to evaluate the association between CD30 and clinicopathological and prognostic significance. CD30 expression was detected using immunohistochemistry on paraffin-embedded sections obtained from 122 patients with ENKTL prior to treatment. In total, 70 of these patients with complete clinical data were collected for prognostic analysis...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454118/simultaneous-exposure-to-fc%C3%AE-r-and-fc%C3%AE-r-on-monocytes-and-macrophages-enhances-antitumor-activity-in-vivo
#10
Bingyu Li, Lijun Xu, Fei Tao, Kun Xie, Zhiqiang Wu, You Li, Jie Li, Kaiming Chen, Chenyu Pi, Andrew Mendelsohn, James W Larrick, Hua Gu, Jianmin Fang
Therapeutic antibodies are effective for tumor immunotherapy and exhibit prominent clinical effects. All approved antibody therapeutics utilize IgG as the molecular format. Antibody-dependent cell-mediated cytotoxicity (ADCC) is a key mechanism for tumor cell killing by antibodies. For IgG antibodies, ADCC depends on FcγR-expressing cells, such as natural killer (NK) cells. However, in patients with a high tumor burden, antibody therapeutics may lose efficacy owing to exhaustion of FcγR-expressing effector cells as well as the inhibitory effects of certain FcγRs on effector cells...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454112/the-challenge-of-treating-hepatitis-c-virus-associated-cryoglobulinemic-vasculitis-in-the-era-of-anti-cd20-monoclonal-antibodies-and-direct-antiviral-agents
#11
REVIEW
Dario Roccatello, Savino Sciascia, Daniela Rossi, Laura Solfietti, Roberta Fenoglio, Elisa Menegatti, Simone Baldovino
Mixed cryoglobulinemia syndrome (MC) is a systemic vasculitis involving kidneys, joints, skin, and peripheral nerves. While many autoimmune, lymphoproliferative, and neoplastic disorders have been associated with this disorder, hepatitis C virus (HCV) is known to be the etiologic agent in the majority of patients. Therefore, clinical research has focused on anti-viral drugs and, more recently, on the new, highly potent Direct-acting Antiviral Agents (DAAs). These drugs assure sustained virologic response (SVR) rates >90%...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454078/new-complexes-of-cu-ii-with-dipicolinate-and-pyridyl-based-ligands-an-experimental-and-dft-approach
#12
Florencia Luzardo, Natalia Álvarez, Carlos Kremer, Andrea S S de Camargo, Jorge S Gancheff
The three novel mononuclear copper(II) complexes with dipicolinate and pyridyl-based ligands [Cu(dipic)(L)(OH2)] (L=4-picoline, vinylpyridine, 4-styrylpyridine; dipic(2-)=dipicolinate) were afforded and structurally characterized. X-ray diffraction studies accounted for slight distorted square-pyramidal structures in which the dianion dipic(2-) acts as a tridentate ligand in a mer-fashion, the N-donor species occupy an in-plane position, and a water molecule was detected apically coordinated. To assess the effect of the nature of the pyridyl-substituent (para position) on electronic properties, other complexes were also synthesized: [Cu(dipic)(py)(OH2)], [{Cu(dipic)(OH2)}2(μ-pyz)] and [{Cu(dipic)(OH2)}(μ-pypy){Cu(dipic)}] (py=pyridine, pyz=pyrazine, pypy=(E)-1,2-bis(pyridine-4-yl)ethane)...
April 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28454062/self-assembled-dehydropeptide-nano-carriers-for-delivery-of-ornidazole-and-curcumin
#13
Smriti Rekha Deka, Santosh Yadav, Dheeresh Kumar, Sumit Garg, Manohar Mahato, Ashwani Kumar Sharma
In the recent studies, it has been demonstrated that incorporation of unnatural amino acid, α,β-dehydrophenylalanine, in small peptides results in stable self-assembled nanostructures with different sizes and shapes. Here, we have replaced the natural amino acid, phenylalanine, from our earlier reported work on self-assembled peptide, Boc-Pro-Phe-Gly-OMe, with a constrained dehydro amino acid, α,β-dehydrophenylalanine, to study its influence on self-assembled nanostructures. Dehydrotripeptide, Boc-Pro-ΔPhe-Gly-OMe, self-assembled into nanostructures in aqueous solutions and formed hydrophobic matrix with improved encapsulation efficiency of hydrophobic molecules...
April 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28454057/application-of-2d-nmr-with-room-temperature-nmr-probes-for-the-assessment-of-the-higher-order-structure-of-filgrastim
#14
Robert G Brinson, Houman Ghasriani, Derek J Hodgson, Kristie M Adams, Ian McEwen, Darón I Freedberg, Kang Chen, David A Keire, Yves Aubin, John P Marino
The higher order structure (HOS) of biotherapeutics is a critical quality attribute that can be evaluated by nuclear magnetic resonance (NMR) spectroscopy at atomic resolution. NMR spectral mapping of HOS can be used to establish HOS consistency of a biologic across manufacturing changes or to compare a biosimilar to an innovator reference product. A previous inter-laboratory study performed using filgrastim drug products demonstrated that two-dimensional (2D)-NMR (1)H(N)-(15)N(H) heteronuclear correlation spectroscopy is a highly robust and precise method for mapping the HOS of biologic drugs at natural abundance using high sensitivity NMR 'cold probes...
April 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28454036/a-clean-environmental-week-let-the-nature-breathe
#15
Khaled Moustafa
High levels of CO2 emissions in the atmosphere and toxic pollutants in air, water and food have serious repercussions on all life's systems, including living beings, environment and economy. Everyone on the Earth is concerned by pollution in some way or another, no matter where and how the pollution is produced as airborne and foodborne pollutants could circulate around the world in different ways, through for example climate components (wind, rain) and/or import and export of foodstuffs. Similarly to living beings that take advantage of day-night circadian rhythms to recover after diurnal hardships, the environment in its entirety could also be seen as a complex living system that needs regular breaks to assimilate or ingest toxic pollutants produced during intensive and continuous industrial processes...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454034/immobilization-of-phenanthrene-onto-gemini-surfactant-modified-sepiolite-at-solid-aqueous-interface-equilibrium-thermodynamic-and-kinetic-studies
#16
Shan Zhao, Guohe Huang, Sen Mu, Chunjiang An, Xiujuan Chen
The immobilization of phenanthrene from aqueous phase onto natural and gemini surfactant modified sepiolite was investigated with respect to contact time, pH, ionic strength and temperature. The surface modification was examined through FT-IR characterization, SEM technique, and the thermogravimetric analysis. The maximum sorption capacity of phenanthrene on modified sepiolite was 95.15μgg(-1) with initial PHE concentration 1.0mgL(-1), temperature 293K, pH7, and ionic strength 1M. The corresponding PHE removal efficiency was higher than 95%...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454024/disentangling-the-effects-of-species-diversity-and-intraspecific-and-interspecific-tree-size-variation-on-aboveground-biomass-in-dry-zone-homegarden-agroforestry-systems
#17
Arshad Ali, Eskil Mattsson
The biodiversity - aboveground biomass relationship has been intensively studied in recent decades. However, no consensus has been arrived to consider the interplay of species diversity, and intraspecific and interspecific tree size variation in driving aboveground biomass, after accounting for the effects of plot size heterogeneity, soil fertility and stand quality in natural forest including agroforests. We tested the full, partial and no mediations effects of species diversity, and intraspecific and interspecific tree size variation on aboveground biomass by employing structural equation models (SEMs) using data from 45 homegarden agroforestry systems in Sri Lanka...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454022/quantitative-analysis-of-adsorptive-interactions-of-ionic-and-neutral-pharmaceuticals-and-other-chemicals-with-the-surface-of-escherichia-coli-cells-in-aquatic-environment
#18
Chul-Woong Cho, Jeong-Soo Park, Yufeng Zhao, Yeoung-Sang Yun
Since Escherichia coli is ubiquitous in nature and has been applied to biological, chemical, and environmental processes, molecular-level understanding of adsorptive interactions between chemicals and the bacterial surface is of great importance. To characterise the adsorption properties of the surface of E. coli cells in aquatic environment, the binding affinities (log Kd) of calibration compounds were experimentally measured, and then based on the values and numerically well-defined molecular interaction forces, i...
April 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28454019/adsorption-of-carbon-dots-onto-al2o3-in-aqueous-experimental-and-theoretical-studies
#19
Xia Liu, Jiaxing Li, Xiaohua Wu, Zhi Zeng, Xianlong Wang, Tasawar Hayat, Xiaodong Zhang
Increasing interests in carbon dots (CDs) research resulted in the increased production of CDs and the risk to be released into the environment, including surface water and groundwater. To assess the environmental behavior of CDs, the stability of CDs in aqueous solutions were first examined by different environmental conditions, followed by the systematic investigation of the adsorption behaviors of CDs onto Al2O3 surface. Electrostatic interactions were considered as the dominant forces in CDs adsorption onto Al2O3 process, which were further confirmed by controlling experiments as compared with other minerals or oxides, such as montmorillonite, kaolinite and SiO2...
April 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28453997/between-a-conditional-s-antecedent-and-its-consequent-discourse-coherence-vs-probabilistic-relevance
#20
Karolina Krzyżanowska, Peter J Collins, Ulrike Hahn
Reasoning with conditionals is central to everyday life, yet there is long-standing disagreement about the meaning of the conditional. One example is the puzzle of so-called missing-link conditionals such as "if raccoons have no wings, they cannot breathe under water." Their oddity may be taken to show that conditionals require a connection between antecedent ("raccoons have no wings") and consequent ("they cannot breathe under water"), yet most accounts of conditionals attribute the oddity to natural-language pragmatics...
April 25, 2017: Cognition
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