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https://www.readbyqxmd.com/read/28923783/bmp7-induced-pten-inhibits-akt-and-prevents-renal-fibrosis
#1
Debra F Higgins, Leah Ewart, Enda Masterson, Sadhbh Tennant, Gleb Grebnev, Marco Prunotto, Sylvia Pomposiello, Karin Conde-Knape, Finian M Martin, Catherine Godson
Bone morphogenetic protein-7 (BMP-7) counteracts pro-fibrotic effects of TGFβ1 in cultured renal cells and protects from fibrosis in acute and chronic renal injury models. Using the unilateral ureteral obstruction (UUO) model of chronic renal fibrosis, we investigated the effect of exogenous-rhBMP-7 on pro-fibrotic signaling pathways mediated by TGFβ1 and hypoxia. Mice undergoing UUO were treated with vehicle or rhBMP-7 (300μg/kg i.p.) every other day for eight days and kidneys analysed for markers of fibrosis and SMAD, MAPK, and PI3K signaling...
September 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28922303/perioperative-outcomes-complications-and-efficacy-of-robotic-assisted-prolapse-repair-a-single-institution-study-of-196-patients
#2
Priyanka Gupta, Michael Ehlert, Jamie Bartley, Jason Gilleran, Kim A Killinger, Judith A Boura, Pradeep Nagaraju, Melissa Fischer
Abdominal pelvic organ prolapse repair is efficacious for uterovaginal and apical prolapse. We describe the safety and efficacy of robotic prolapse repair in a large teaching institution. METHODS: Consecutive robotic-assisted prolapse repairs at a single institution between 2006 and 2014 were retrospectively reviewed for patient characteristics, operative information, and outcomes. RESULTS: A total of 196 women (mean age, 61 ± 9 years) underwent robotic prolapse repair (189 sacrocolpopexy, 6 sacrohysteropexy, 1 enterocele repair)...
September 15, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28903945/complement-c5a-receptors-c5l2-and-c5ar-in-renal-fibrosis
#3
Ina V Martin, Annika Bohner, Peter Boor, Erdenechimeg Shagdarsuren, Ute Raffetseder, Frank Lammert, Jürgen Floege, Tammo Ostendorf, Susanne N Weber
Complement factor C5a has two known receptors, C5aR mediating pro-inflammatory effects and C5L2, a potential C5a scavenger. We previously identified C5a/C5aR signaling as a potent profibrotic pathway in the kidney. Here we tested for the first time the role of C5L2 in renal fibrosis. In unilateral ureteral obstruction (UUO)-induced kidney fibrosis, the expression of C5aR and C5L2 increased similarly and gradually as fibrosis progressed and was particularly prominent in injured dilated tubules. Genetic deficiency of either C5aR or C5L2 significantly reduced UUO-induced tubular injury...
September 13, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28882779/safety-and-effectiveness-of-holmium-laser-enucleation-of-the-prostate-using-a-low-power-laser
#4
Shingo Minagawa, Shinsuke Okada, Hirofumi Morikawa
OBJECTIVE: To assess the safety and effectiveness of holmium laser enucleation of the prostate (HoLEP) using a low-power 30 W holmium laser with an en-bloc enucleation technique. METHODS: We retrospectively analyzed 74 patients with a diagnosis of benign prostatic hyperplasia treated with HoLEP using a 30 W laser set at 1.5 J with a frequency of 20 Hz, as a low-power setting. The enucleation process was performed using the en-bloc technique. Forty-four patients were operated on by an experienced surgeon, while 30 patients were operated on by 2 less experienced surgeons...
September 4, 2017: Urology
https://www.readbyqxmd.com/read/28882772/early-elective-versus-delayed-elective-surgery-in-acute-recurrent-diverticulitis-a-systematic-review-and-meta-analysis
#5
REVIEW
Rao Muhammad Asaf Khan, Shahin Hajibandeh, Shahab Hajibandeh
OBJECTIVES: To investigate outcomes of early versus delayed surgery in patients with acute recurrent diverticulitis. METHODS: We performed a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement standards. We conducted a search of electronic information sources, including MEDLINE; EMBASE; CINAHL; the Cochrane Central Register of Controlled Trials (CENTRAL); the World Health Organization International Clinical Trials Registry; ClinicalTrials...
September 4, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28881491/in-vivo-x-ray-imaging-of-transport-of-renal-clearable-gold-nanoparticles-in-the-kidneys
#6
Jie Zheng, Jing Xu, Mengxiao Yu, Phoebe Carter, Elizabeth Hernandez, Andrew Dang, Payal Kapur, Jer-Tsong Hsieh
With more and more engineered nanoparticles (NPs) being designed renal clearable for clinical translation, fundamental understandings of their transport in the different compartments of kidneys become increasingly important. Here, we report noninvasive X-ray imaging of renal clearable gold NPs (AuNPs) in normal and nephropathic kidneys. By quantifying the transport kinetics of the AuNPs in cortex, medulla and pelvis of the normal and injured kidneys, we found that ureteral obstruction not just blocked the NP elimination through the ureter but also slowed down their transport from the medulla to pelvis and enhanced the cellular uptake...
September 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28870174/local-cd34-positive-capillaries-decrease-in-mouse-models-of-kidney-disease-associating-with-the-severity-of-glomerular-and-tubulointerstitial-lesions
#7
Md Abdul Masum, Osamu Ichii, Yaser Hosny Ali Elewa, Teppei Nakamura, Yasuhiro Kon
BACKGROUND: The renal vasculature plays important roles in both homeostasis and pathology. In this study, we examined pathological changes in the renal microvascular in mouse models of kidney diseases. METHODS: Glomerular lesions (GLs) in autoimmune disease-prone male BXSB/MpJ-Yaa (Yaa) mice and tubulointerstitial lesions (TILs) in male C57BL/6 mice subjected to unilateral ureteral obstruction (UUO) for 7 days were studied. Collected kidneys were examined using histopathological techniques...
September 4, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28861678/perioperative-serum-creatinine-changes-and-ureteral-injury
#8
Sam Siddighi, Junchan J Yune, Nicole B Kwon, Jeffrey S Hardesty, Joo H Kim, Philip J Chan
PURPOSE: To illustrate a simple method that screens for ureteral injury in the acute postoperative period after urogynecologic surgeries. METHODS: Serum creatinine measurements in the preoperative (baseline) and postoperative periods of urogynecologic surgeries were determined and the correlation of the change to ureteral injury and/or obstruction analyzed. The sample size calculation showed 7 cases and 28 controls were sufficient to detect significant changes in creatinine...
September 1, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28861302/factors-associated-with-postoperative-pain-after-retrograde-intrarenal-surgery-for-kidney-stones
#9
Ural Oğuz, Tolga Şahin, Çağrı Şenocak, Ekrem Özyuvalı, Ömer Faruk Bozkurt, Berkan Reşorlu, Ali Ünsal
OBJECTIVE: We aimed to investigate factors related to early postoperative pain after retrograde intrarenal surgery (RIRS). MATERIAL AND METHODS: A prospective data analysis of 250 patients who underwent RIRS due to kidney stones was performed. Postoperative pain was evaluated in all patients by using visual analogue scale (VAS). Patients with severe pain (VAS score ≥7) were separated and included in Group I (n=46). While patients without pain or with insignificant pain were included in Group II (n=204)...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28852460/ureterovaginal-fistula-following-spontaneous-vaginal-delivery-repaired-by-vaginal-ureteroneocystostomy-in-a-low-resource-setting
#10
Sunday J Lengmang, Abubakar B Dakingari, Paul Ushie, George A A Chima, Edwin Oseni-Momudu
Ureterovaginal fistula commonly follows ureteric injury during pelvic surgery, and presents with continuous urinary incontinence in spite of normal micturition. Continuous urinary incontinence has significant impact on quality of life, thus requiring effective surgical intervention in order to restore health. We found no reported case of ureterovaginal fistula following spontaneous vaginal delivery with prolonged obstructed labour. Relevant history and simple diagnostic procedures were used for diagnosis and the patient had successful vaginal ureteroneocystostomy...
July 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28842376/theranostic-poly-lactic-co-glycolic-acid-nanoparticle-for-magnetic-resonance-infrared-fluorescence-bimodal-imaging-and-efficient-sirna-delivery-to-macrophages-and-its-evaluation-in-a-kidney-injury-model
#11
Chuanxu Yang, Hieu Vu-Quang, Dina Michelle Unnerup Husum, Stine Julie Tingskov, Mads Sloth Vinding, Thomas Nielsen, Ping Song, Niels Chr Nielsen, Rikke Nørregaard, Jørgen Kjems
In this work, a theranostic nanoparticle was developed for multimodal imaging and siRNA delivery. The core of the nanoparticles (NP) was formed by encapsulation of superparamagnetic iron oxides and indocyanine green in a PLGA matrix to serve as a multimodal probe for near-infrared (NIFR) and magnetic resonance (MR) imaging. The surface of the particle was coated with polyethylenimine (PEI) for siRNA delivery. Macrophages efficiently took up the nanoparticles and emitted strong NIFR and MR contrast. When transfected with siRNA targeting the pro-inflammatory enzyme cyclooxygenase-2 (COX-2), significant down-regulation of COX-2 was achieved in activated macrophages...
August 22, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28836250/-clinical-efficacy-of-superior-mesenteric-artery-oriented-laparoscopic-complete-mesocolic-excision-in-the-treatment-of-right-colonic-cancer
#12
Yong Wang, Dongsheng Zhang, Yifei Feng, Zan Fu, Ziwei Xu, Yueming Sun
OBJECTIVE: To investigate the clinical efficacy of superior mesenteric artery (SMA)-oriented laparoscopic complete mesocolic excision (CME) with a medial-to-lateral approach in the treatment of right colonic cancer. METHODS: A total of 166 patients with right colonic cancer who were admitted to The First Affiliated Hospital of Nanjing Medical University from January 2015 to December 2016 underwent SMA-oriented laparoscopic CME by the same surgical team. Clinical data of these patients were retrospectively analyzed...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28830243/device-related-adverse-events-during-percutaneous-nephrolithotomy-review-of-the-manufacturer-and-user-facility-device-experience-maude-database
#13
Neel H Patel, Ariel Schulman, Jonathan Bloom, Nikil Uppaluri, John L Phillips, Sensuke Konno, Muhammed Choudhury, Majid Eshghi
INTRODUCTION AND OBJECTIVES: Percutaneous Nephrolithotomy (PCNL) is an established technique for removal of large stones from the upper urinary tract. It is a complex, multistep procedure requiring several classes of instruments that are subject to operator misuse and device malfunction. We report device-related adverse events during PCNL from the MAUDE database using a recently developed standardized classification system. METHODS: The MAUDE database was queried for "percutaneous nephrolithotomy" from 2006 to 2016...
August 22, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28828690/kidney-autotransplantation-long-term-outcomes-and-complications-experience-in-a-tertiary-hospital-and-literature-review
#14
Mercedes Ruiz, Vital Hevia, Jose-Javier Fabuel, Alvaro-Amancio Fernández, Victoria Gómez, Francisco-Javier Burgos
OBJECTIVE: To analyze indications, surgical technique, complications and long-term outcomes of kidney autotransplantation (KAT) after 26-year experience at a single institution. MATERIALS AND METHODS: A retrospective observational study of patients who underwent KAT at our institution (January 1990-December 2016) was carried out. Data collected included indications, surgical technique, complications (Clavien-Dindo), hospital stay and long-term outcomes. Literature review was performed through MEDLINE and ClinicalKey databases including "kidney," "renal," "autotransplantation" and "autograft...
August 21, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28827403/targeting-anti-tgf-%C3%AE-therapy-to-fibrotic-kidneys-with-a-dual-specificity-antibody-approach
#15
Steve McGaraughty, Rachel A Davis-Taber, Chang Z Zhu, Todd B Cole, Arthur L Nikkel, Meha Chhaya, Kelly J Doyle, Lauren M Olson, Gregory M Preston, Christine M Grinnell, Katherine M Salte, Anthony M Giamis, Yanping Luo, Victor Sun, Andrew D Goodearl, Murali Gopalakrishnan, Susan E Lacy
Targeted delivery of a therapeutic agent to a site of pathology to ameliorate disease while limiting exposure at undesired tissues is an aspirational treatment scenario. Targeting diseased kidneys for pharmacologic treatment has had limited success. We designed an approach to target an extracellular matrix protein, the fibronectin extra domain A isoform (FnEDA), which is relatively restricted in distribution to sites of tissue injury. In a mouse unilateral ureteral obstruction (UUO) model of renal fibrosis, injury induced significant upregulation of FnEDA in the obstructed kidney...
August 21, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28816278/-analysis-of-development-safety-and-efficacy-of-percutaneous-nephrolithotomy-for-management-of-upper-urinary-tract-calculi-in-pediatric-patients
#16
L P Yu, T Xu
OBJECTIVE: To evaluate the development, safety and efficacy of percutaneous nephrolithotomy(PNL) for management of upper urinary tract calculi in pediatric patients. METHODS: In the study, 77 pediatric patients undergoing 87 PNLs through mini or standard tract for upper urinary tract calculi between January 2005 and December 2016 in Peking University People's hospital were reviewed, including 69 renal calculi, 6 upper ureteral calculi, 12 renal and upper ureteral calculi, 35 single calculi, 43 multiple calculi and 9 staghorn calculi...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28804662/fungal-bezoar-a-rare-cause-of-ureteral-obstruction
#17
Nabil Zeineddine, Wissam Mansour, Sandy El Bitar, Marco Campitelli, Neville Mobarakai
A 52-year-old male, with diabetes mellitus and alcoholic liver disease, presented to the Emergency Room for right flank pain of 3 days' duration, associated with dysuria. Physical examination revealed right flank tenderness with fever and hypotension; laboratory findings showed acute kidney injury and large blood and leucocytes in the urine. A CT abdomen and pelvis showed hydronephrosis of the right collecting system of a horseshoe kidney with air and hyperdense debris in the renal pelvis. Patient was treated for multisensitive Proteus mirabilis emphysematous pyelonephritis, and a right nephrostomy tube was inserted...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28753620/treatment-combining-aliskiren-with-paricalcitol-is-effective-against-progressive-renal-tubulointerstitial-fibrosis-via-dual-blockade-of-intrarenal-renin
#18
Sungjin Chung, Soojeong Kim, Minyoung Kim, Eun Sil Koh, Seok Joon Shin, Cheol Whee Park, Yoon Sik Chang, Ho-Shik Kim
The aim of this study was to assess any potential additive effects of a treatment combining aliskiren with paricalcitol on reducing renal fibrosis. C57BL/6J mice were treated individually with aliskiren and/or paricalcitol until 7 days after initiation of unilateral ureteral obstruction (UUO).In obstructed kidneys of UUO mice, monotherapy with aliskiren or paricalcitol significantly attenuated interstitial fibrosis, collagen IV accumulation, and α-smooth muscle actin- and terminal deoxynucleotidyl transferase-mediated biotin nick end-labeling-positive cells...
2017: PloS One
https://www.readbyqxmd.com/read/28750410/loss-of-the-protein-cystathionine-%C3%AE-synthase-during-kidney-injury-promotes-renal-tubulointerstitial-fibrosis
#19
Xiangning Yuan, Jin Zhang, Feifei Xie, Wenqing Tan, Shuting Wang, Ling Huang, Lijian Tao, Qiqi Xing, Qiongjing Yuan
BACKGROUND/AIMS: Renal tubulointerstitial fibrosis (TIF) is the common pathway of progressive chronic kidney disease. Inflammation has been widely accepted as the major driving force of TIF. Cystathionine β-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway. CBS is considered to play protective role in liver and pulmonary fibrosis, but its role in TIF remains unknown. The purpose of this study was to investigate the potential role and mechanism of CBS in renal inflammation and TIF...
July 27, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28739141/amp-activated-protein-kinase-myocardin-related-transcription-factor-a-signaling-regulates-fibroblast-activation-and-renal-fibrosis
#20
Yuguo Wang, Li Jia, Zhaoyong Hu, Mark L Entman, William E Mitch, Yanlin Wang
Chronic kidney disease is a major cause of death, and renal fibrosis is a common pathway leading to the progression of this disease. Although activated fibroblasts are responsible for the production of the extracellular matrix and the development of renal fibrosis, the molecular mechanisms underlying fibroblast activation are not fully defined. Here we examined the functional role of AMP-activated protein kinase (AMPK) in the activation of fibroblasts and the development of renal fibrosis. AMPKα1 was induced in the kidney during the development of renal fibrosis...
July 21, 2017: Kidney International
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