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Ureteral injury

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https://www.readbyqxmd.com/read/28413644/reduction-in-mirna-125b-5p-levels-is-associated-with-obstructive-renal-injury
#1
Silu Wang, Lianfeng Wu, Linyong Du, Hong Lu, Bicheng Chen, Yongheng Bai
Obstructive renal injury is a common disease that leads to progressive glomerulosclerosis, tubulointerstitial fibrosis and loss of renal function. MicroRNAs (miRNAs/miRs) are small non-coding molecules that may be involved in the progression of many renal diseases. The aim of the present study was to investigate the roles of miRNAs, including miR-125b, miR-326 and miR-324p, in obstructive renal injury. Blood samples were collected from 91 patients with ureteral obstruction and 76 controls to examine renal function...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28411456/urinary-bladder-injury-during-cesarean-delivery-maternal-outcome-from-a-contemporary-large-case-series
#2
Lina Salman, Shachar Aharony, Anat Shmueli, Arnon Wiznitzer, Rony Chen, Rinat Gabbay-Benziv
BACKGROUND: Urinary bladder injury is a rare complication during cesarean delivery. Little is known on maternal outcome following this injury. OBJECTIVE: To evaluate short and long-term maternal outcome following bladder injury during cesarean delivery. STUDY DESIGN: A retrospective case series of all pregnancies complicated by full-thickness bladder injury during cesarean delivery in a single university affiliated tertiary medical center (August 2007-June 2016)...
April 5, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28404199/bowel-function-after-laparoscopic-posterior-sutured-rectopexy-versus-ventral-mesh-rectopexy-for-rectal-prolapse-a-double-blind-randomised-single-centre-study
#3
Lilli Lundby, Lene H Iversen, Steen Buntzen, Pål Wara, Katrine Høyer, Søren Laurberg
BACKGROUND: Laparoscopic ventral mesh rectopexy for rectal prolapse has been widely used over the past decade to reduce postoperative functional bowel disorders. We aimed to compare changes in functional outcome 12 months after laparoscopic ventral mesh rectopexy versus laparoscopic posterior sutured rectopexy in patients with rectal prolapse. METHODS: In this double-blind, randomised trial, consecutive patients aged 18 years or older at a single centre in Denmark with full-thickness rectal prolapse were randomly assigned (1:1) to either laparoscopic ventral mesh rectopexy or laparoscopic posterior sutured rectopexy by drawing numbers from opaque envelopes, in blocks of four for patients with or without preoperative constipation...
December 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403495/-diagnosis-and-therapeutic-management-in-kidney-ureter-and-bladder-trauma
#4
Karin Hirsch, Marco Heinz, Bernd Wullich
Trauma refers to the destruction of tissues or organs by external forces and it is the most common cause of mortality and morbidity in children (1, 2). Injuries of the genitourinary tract may be the result of blunt (falls, sport injuries, motor vehicle accidents and sexual abuse) or penetrating (stab wounds, gun shots, falling onto sharp objects) injuries. The genitourinary tract is significantly injured in 2.9% of paediatric trauma patients 4.In the paediatric population, the kidney is the most affected organ in the genitourinary tract (>60% of all genitourinary tract injuries) 4...
February 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28402979/the-inhibitory-effect-of-eplerenone-on-cell-proliferation-in-the-contralateral-kidneys-of-rats-with-unilateral-ureteral-obstruction
#5
Cong-Hui Wang, Zheng Wang, Li-Juan Liang, Xiang-Ting Wang, Xue-Lian Ma, Bei-Bei Liu, Jia-Qi He, Tatsuo Shimosawa, Qing-You Xu
BACKGROUND: The unilateral ureteral obstruction (UUO) model not only induces renal interstitial fibrosis in the obstructed kidney but also induces injury in the contralateral kidney. We hypothesized that activation of the mineralocorticoid receptor (MR) may induce fibrosis in the early stage of UUO. METHODS: Thirty male Sprague-Dawley rats weighting 200 ± 10 g were used in this study and randomly divided into 3 groups: a UUO group, a UUO and eplerenone group, and a sham group...
April 13, 2017: Nephron
https://www.readbyqxmd.com/read/28388304/laparoscopic-ureteroureterostomy-with-an-intraoperative-retrograde-ureteroscopy-assisted-technique-for-distal-ureteral-injury-secondary-to-gynecological-surgery-a-retrospective-comparison-with-laparoscopic-ureteroneocystostomy
#6
Zhaohui Wang, Zhi Chen, Yao He, Bingsheng Li, Zhiqiang Wen, Xiang Chen
OBJECTIVES: The aim of this study was to compare the operative and postoperative outcomes of laparoscopic ureteroureterostomy (LAP-UU) using a retrograde ureteroscopy-assisted technique with laparoscopic ureteroneocystostomy (LAP-UNC) in treating ureteral injury after gynecological surgery. MATERIALS AND METHODS: The study analyzed 60 ureteral injury repairs performed between May 2010 and February 2016 in patients who underwent either LAP-UU using the retrograde ureteroscopy-assisted technique (n = 26) or LAP-UNC (n = 34)...
April 7, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28381270/a-rare-diaphragmatic-ureteral-herniation-case-report-endoscopic-and-open-reconstructive-management
#7
Frank C Lin, Jamie S Lin, Samuel Kim, Jonathan R Walker
BACKGROUND: Ureteral herniations are a rare occurrence, generally found incidentally on cross sectional imaging or during surgical intervention for unrelated processes. Several locations of ureteral herniations can occur including the inguinal, femoral, sciatic, obturator, and thoracic regions. While few reports of ureteral hernias are reported in the literature overall, the vast majority of those reported are inguinoscrotal herniations found during evaluation and treatment of inguinal hernias...
April 5, 2017: BMC Urology
https://www.readbyqxmd.com/read/28378840/alpha-lipoic-acid-ameliorates-the-epithelial-mesenchymal-transition-induced-by-unilateral-ureteral-obstruction-in-mice
#8
Hyun Seop Cho, Jin Hyun Kim, Ha Nee Jang, Tae Won Lee, Myeong Hee Jung, Tae Ho Kim, Se-Ho Chang, Dong Jun Park
The epithelial-to-mesenchymal transition (EMT) is one of mechanisms that induce renal interstitial fibrosis. Understanding EMT in renal fibrosis has important therapeutic implications for patients with kidney disease. Alpha-lipoic acid (ALA) is a natural compound with antioxidant properties. Studies for ALA are performed in acute kidney injury with renal tubular apoptosis, renal inflammation, and oxidative stress. We investigated the effects of ALA on EMT-mediated renal interstitial fibrosis in mice with unilateral ureteral obstruction (UUO)...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28351191/acute-kidney-injury-after-percutaneous-nephrolithotomy-for-stones-in-solitary-kidneys
#9
Ahmed R El-Nahas, Diaa-Eldin Taha, Hussien M Ali, Ahmed M Elshal, Mohamed H Zahran, Nasr A El-Tabey, Ahmed M El-Assmy, Ahmed M Harraz, Hazem E Moawad, Mahmoud M Othman
OBJECTIVES: The aim of this study was to report the incidence, severity, outcome and risk factors of acute kidney injury (AKI) following percutaneous nephrolithotomy (PNL) in solitary kidneys. METHODS: The study included consecutive adult patients who underwent PNL for treatment of calculi in a solitary kidney between May 2012 and July 2015. Patients with congenital renal anomalies or with stages 4 and 5 chronic kidney disease (CKD) were excluded. Serum creatinine levels were measured the day before PNL, daily after PNL for 2-5 days and after 3 months...
March 29, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28348462/nlrp3-deficiency-attenuates-renal-fibrosis-and-ameliorates-mitochondrial-dysfunction-in-a-mouse-unilateral-ureteral-obstruction-model-of-chronic-kidney-disease
#10
Honglei Guo, Xiao Bi, Ping Zhou, Shijian Zhu, Wei Ding
Background and Aims. The nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney disease (CKD); however, its exact role in glomerular injury and tubulointerstitial fibrosis is still undefined. The present study was performed to identify the function of NLRP3 in modulating renal injury and fibrosis and the potential involvement of mitochondrial dysfunction in the murine unilateral ureteral obstruction (UUO) model of CKD...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28336721/tubule-derived-wnts-are-required-for-fibroblast-activation-and-kidney-fibrosis
#11
Dong Zhou, Haiyan Fu, Lu Zhang, Ke Zhang, Yali Min, Liangxiang Xiao, Lin Lin, Sheldon I Bastacky, Youhua Liu
Cell-cell communication via Wnt ligands is necessary in regulating embryonic development and has been implicated in CKD. Because Wnt ligands are ubiquitously expressed, the exact cellular source of the Wnts involved in CKD remains undefined. To address this issue, we generated two conditional knockout mouse lines in which Wntless (Wls), a dedicated cargo receptor that is obligatory for Wnt secretion, was selectively ablated in tubular epithelial cells or interstitial fibroblasts. Blockade of Wnt secretion by genetic deletion of Wls in renal tubules markedly inhibited myofibroblast activation and reduced renal fibrosis after unilateral ureteral obstruction...
March 23, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28335679/puerarin-attenuates-renal-fibrosis-by-reducing-oxidative-stress-induced-epithelial-cell-apoptosis-via-mapk-signal-pathways-in-vivo-and-in-vitro
#12
Xiangjun Zhou, Chen Bai, Xinbo Sun, Xiaoxin Gong, Yong Yang, Congbo Chen, Guang Shan, Qisheng Yao
Puerarin (PR) is an isoflavonoid isolated from the root of the plant Pueraria lobata and has been widely used in traditional Chinese herbal medicine for the treatment of various diseases. Oxidative stress and epithelial cell apoptosis play important roles in the renal fibrotic process. The present study aimed to determine whether or not PR inhibits renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis. In vivo, unilateral ureteral obstruction (UUO) induced renal fibrosis, and epithelial cell apoptosis...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28332142/flat-detector-cone-beam-ct-guided-nephrostomy-using-virtual-navigation-in-patients-with-iatrogenic-ureteral-injury
#13
Dechao Jiao, Zongming Li, Zhiguo Li, Shaofeng Shui, Xin-Wei Han
PURPOSE: To evaluate the feasibility of flat detector cone beam computed tomography (CBCT)-guided nephrostomy using virtual navigation in patients with iatrogenic ureteral injury. MATERIALS AND METHODS: A retrospective review of percutaneous nephrostomy (PN) revealed the use of CBCT with 3D virtual navigation guidance in 42 procedures (40 patients) for patients with iatrogenic ureteral injury. All procedures were shown as second-line interventions after failed ultrasound-guided nephrostomy...
March 22, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28331063/microrna-148b-regulates-megalin-expression-and-is-associated-with-receptor-downregulation-in-mice-with-unilateral-ureteral-obstruction
#14
Lu Wen, Pia K Andersen, Dina Mu Husum, Rikke Norregaard, Zhanzheng Zhao, Zhangsuo Liu, Henrik Birn
Megalin is a multiligand, endocytic receptor important for the normal, proximal tubule reabsorption of filtered proteins, hormones, enzymes, essential nutrients, and nephrotoxins. Megalin dysfunction has been associated with acute as well as chronic kidney diseases. Tubular proteinuria has been observed following unilateral ureteral obstruction (UUO) suggesting megalin dysfunction; however, the pathophysiological mechanism has not been resolved. In order to identify potential regulators of megalin expression, we examined renal microRNAs (miRNAs) expression and observed an upregulation of microRNA-148b (miR-148b) in obstructed mouse kidneys 7 days after UUO which was associated with a significant reduction in proximal tubule megalin expression and accumulation of megalin ligands...
March 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28298077/effects-of-colchicine-on-renal-fibrosis-and-apoptosis-in-obstructed-kidneys
#15
Sejoong Kim, Eun Sook Jung, Jeonghwan Lee, Nam Ju Heo, Ki Young Na, Jin Suk Han
Background/Aims: Colchicine is an established drug for microtubule stabilization that may reduce tissue injury. No data were available that its effects may depend on the dosage of colchicine. We investigated the anti-fibrotic and apoptotic effects of various dose of colchicine in a unilateral ureteral obstruction (UUO) model. Methods: Thirty-six Sprague-Dawley rats were randomly assigned into six groups. Two sham groups were divided into a vehicle-treated or colchicine-treated group (100 μg/kg/day)...
March 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28285987/tgf%C3%AE-incurred-epigenetic-aberrations-of-mirna-and-dna-methyltransferase-suppress-klotho-and-potentiate-renal-fibrosis
#16
Shasha Yin, Qin Zhang, Jun Yang, Wenjun Lin, Yanning Li, Fang Chen, Wangsen Cao
Renal fibrosis is a common pathological feature of chronic kidney diseases (CKD) and its development and progression are significantly affected by epigenetic modifications such as aberrant miRNA and DNA methylation. Klotho is an anti-aging and anti-fibrotic protein and its early decline after renal injury is reportedly associated with aberrant DNA methylation. However, the key upstream pathological mediators and the molecular cascade leading to epigenetic Klotho suppression are not exclusively established. Here we investigate the epigenetic mechanism of Klotho deficiency and its functional relevance in renal fibrogenesis...
March 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28277596/the-mccarus-volker-fornisee%C3%A2-a-novel-trans-illuminating-colpotomy-device-and-uterine-manipulator-for-use-in-conventional-and-robotic-assisted-laparoscopic-hysterectomy
#17
Melissa M Gutierrez, Jasmine D Pedroso, K Warren Volker, David L Howard, Steven D McCarus
PURPOSE: The purpose of this paper is to introduce a novel trans-illuminating culdotomy and uterine manipulator device. MATERIALS AND METHODS: The study was a prospective, non-randomized, non-blinded observational clinical study involving 50 female patients undergoing total laparoscopic hysterectomy (TLH) or laparoscopic supracervical hysterectomy (LSH) for benign indications. The surgeries were performed from March through May 2012 at two institutions. The primary study objectives were to demonstrate the safety and adequate clinical performance of the uterine manipulator device and to illustrate its potential widespread future use in minimally invasive gynecologic procedures...
March 9, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28272516/the-ligand-bound-thyroid-hormone-receptor-in-macrophages-ameliorates-kidney-injury-via-inhibition-of-nuclear-factor-%C3%AE%C2%BAb-activities
#18
Fumihiko Furuya, Toshihisa Ishii, Shogo Tamura, Kazuya Takahashi, Hidetoshi Kobayashi, Masashi Ichijo, Soichi Takizawa, Masahiro Kaneshige, Katsue Suzuki-Inoue, Kenichiro Kitamura
In chronic kidney disease (CKD) patients, inflammation plays a pivotal role in the progression of renal fibrosis. Hypothyroidism is associated with an increased occurrence of atherosclerosis and inflammation, suggesting protective roles of thyroid hormones and their receptors against inflammatory processes. The contribution of thyroid hormone receptors to macrophage differentiation has not been well documented. Here, we focused on the endogenous thyroid hormone receptor α (TRα) in macrophages and examined the role of ligand-bound TRα in macrophage polarization-mediated anti-inflammatory effects...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28267589/the-retroperitoneal-approach-to-endometriosis
#19
Julian A Gingold, Tommaso Falcone
STUDY OBJECTIVE: To demonstrate principles of laparoscopic management of deeply infiltrating endometriosis requiring retroperitoneal entry. DESIGN: Step-by-step demonstration and explanation of technique using videos from patients with deeply infiltrating stage IV endometriosis who failed medical management (Canadian Task Force classification IIIB). This study was exempt from Institutional Review Board review. SETTING: Large academic medical center...
March 3, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28252557/complications-associated-with-lateral-interbody-fusion-nationwide-survey-of-2998-cases-during-the-first-two-years-of-its-use-in-japan
#20
Shunsuke Fujibayashi, Noriaki Kawakami, Takashi Asazuma, Manabu Ito, Jun Mizutani, Hideki Nagashima, Masaya Nakamura, Koichi Sairyo, Ryuichi Takemasa, Motoki Iwasaki
STUDY DESIGN: Retrospective nationwide questionnaire-based survey of complications. OBJECTIVE: To elucidate the incidence of complications and risk factors associated with lateral interbody fusion (LIF). SUMMARY OF BACKGROUND DATA: After its introduction to Japan in February 2013, the numbers of LIF cases have increased substantially because of the advantages of this minimally invasive procedure. However, LIF has the potential risk of several complications unique to the procedure...
March 1, 2017: Spine
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