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Ureteral injury

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https://www.readbyqxmd.com/read/28526933/protection-of-tubular-epithelial-cells-during-renal-injury-via-post-transcriptional-control-of-bmp7
#1
Jiping Sun, Aiping Yin, Fei Zhao, Wenjing Zhang, Jia Lv, Jing Lv
Severe injury of renal tubular epithelial cells may cause acute renal failure, the progression of which results in renal fibrosis, and obstructive nephropathy. Transforming growth factor β 1 and bone morphogenic protein 7 (BMP7) play contradicting roles in and coordinate the process of epithelial-to-mesenchymal transition of renal tubular epithelial cells, but the molecular regulation of BMP7 remains ill-defined. Here, we addressed this question. We found that after induction of unilateral ureteral obstruction (UUO) in mice, the increases in BMP7 mRNA were much more pronounced than BMP7 protein in kidney, suggesting the presence of post-transcriptional control of BMP7...
May 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28513528/complete-upper-urinary-tract-obstruction-caused-by-penetrating-pellet-injury-of-the-ureterintroduction
#2
M T Gulpinar, S K Keskin, A Yildirim, T Caskurlu
Ureteral injuries due to gunshots are tend to be misdiagnosed because of concomitant vascular and intraabdominal organ wounds. Our case is a 23-year-old man who was admitted to the hospital with multiple abdominal gunshot wounds. Laboratory findings showed worsening anemia, and the computed tomography (CT) scan showed multiple lead bullets inside the abdomen and retroperitoneum. Patient was then taken to the operation room for laparatomy. There were many intestinal injuries and also a stable retroperitoneal hematoma...
May 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28510805/interventional-radiology-in-iatrogenic-ureteral-leaks-case-series-and-literature-review
#3
Claudia Trombatore, Giuseppe Giordano, Vincenzo Magnano San Lio
Iatrogenic ureteral injuries are a dramatic complication in medical practice. Nowadays there are no universal guidelines for their management. The aim of our study was to evaluate the feasibility of the percutaneous treatment in restoring ureteral integrity in 19 patients that came to our attention. In each case retrograde stenting failed and patients were candidates for re-surgery. Our strategy consists of two phases. The first step is the nephrostomy that allows an external urinary diversion putting dry the damaged ureteral segment...
May 16, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28503033/15-deoxy-%C3%AE-12-14-prostaglandin-j2-exerts-antioxidant-effects-while-exacerbating-inflammation-in-mice-subjected-to-ureteral-obstruction
#4
Line Nilsson, Fredrik Palm, Rikke Nørregaard
Urinary obstruction is associated with inflammation and oxidative stress, leading to renal dysfunction. Previous studies have shown that 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) has both antioxidant and anti-inflammatory effects. Using a unilateral ureteral obstruction (UUO) mouse model, we examined the effects of 15d-PGJ2 on oxidative stress and inflammation in the kidney. Mice were subjected to UUO for 3 days and treated with 15d-PGJ2. Protein and RNA expression were examined using immunoblotting and qPCR...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28487937/colchicine-attenuates-renal-fibrosis-in-a-murine-unilateral-ureteral-obstruction-model
#5
Seiji Itano, Minoru Satoh, Hiroyuki Kadoya, Yuji Sogawa, Atsushi Uchida, Tamaki Sasaki, Naoki Kashihara
The present study aimed to assess the effects of colchicine, a known anti‑inflammatory agent, on renal fibrosis using a murine model of unilateral ureteral obstruction (UUO). Male C57BL/6 mice were divided into two groups, vehicle‑ and colchicine‑treated. Colchicine (0.5 mg/kg/day) was administered by osmotic pump, and the UUO procedure was performed on the left kidney 7 days later. The mice were sacrificed at 14 days following UUO. Colchicine treatment suppressed interstitial fibrosis of the UUO kidneys...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28484665/retrospective-review-of-pediatric-blunt-renal-trauma-a-single-institution-s-five-year-experience
#6
Carly R Richards, Margaret E Clark, Ronald S Sutherland, Russell K Woo
Children are at higher risk of renal injury from blunt trauma than adults due to a variety of anatomic factors such as decreased perirenal fat, weaker abdominal muscles, and a less ossified thoracic cage. Non-operative management is gaining in popularity for even major injuries, although there are no universally accepted guidelines. We present a retrospective review of pediatric major blunt renal injuries (grade 3 or higher) at a children's hospital in Hawai'i over a 5-year period. Medical records were examined between January 2009 and September 2014 from Kapi'olani Medical Center for Women and Children in Honolulu, Hawai'i...
May 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28483378/c-myc-promotes-renal-fibrosis-by-inducing-integrin-%C3%AE-v-mediated-transforming-growth-factor-%C3%AE-signaling
#7
Yang Shen, Naijun Miao, Bao Wang, Jinlan Xu, Xinxin Gan, Dan Xu, Li Zhou, Hong Xue, Wei Zhang, Li Yang, Limin Lu
Fibrogenesis involves the activation of renal fibroblasts upon kidney injury. However, the mechanisms underlying renal fibroblast activation are poorly characterized. c-Myc is a predominant oncogene encoding a pleiotropic transcription factor that participates in the regulation of various genes, including genes vital for regulating the cell cycle, cell proliferation, and apoptosis. Here we tested whether renal fibrosis in unilateral ureteral obstruction and folic acid-induced renal fibrosis mouse models are associated with the overexpression of c-Myc...
May 5, 2017: Kidney International
https://www.readbyqxmd.com/read/28479779/ureteric-injury-after-lumbosacral-microdiscectomy-a-case-report-and-review-of-literature
#8
Nitin Garg, Pankaj Panwar, Sudheer Kumar Devana, S M Ravi Mohan, A K Mandal
Microdiscectomy is considered a very safe procedure with few serious complications. Ureteric injury following microdiscectomy is rarely reported in the literature. We report a rare case of iatrogenic ureteric injury following L5-S1 microdiscectomy for prolapsed intervertebral disc which was detected early and managed in time.
April 2017: Urology Annals
https://www.readbyqxmd.com/read/28479761/immediate-ureterovaginal-fistula-following-oocyte-retrieval-a-case-and-systematic-review-of-the-literature
#9
REVIEW
Elysia Sophie Spencer, Heather S Hoff, Anne Z Steiner, Robert Matthew Coward
The aim of this study is to report a case of acute ureterovaginal fistula (UVF) formation with immediate symptomatic presentation after transvaginal ultrasound-guided oocyte retrieval (TVOR) for in vitro fertilization (IVF) and to perform a systematic literature review of ureteral injuries during TVOR. A 33-year-old woman with a history of anovulatory infertility presented with severe abdominal pain and vaginal leakage immediately following TVOR for IVF. We systematically reviewed the current literature regarding ureteral injury resulting from TVOR and present a case of timely identification and management of a UVF followed by a successful pregnancy...
April 2017: Urology Annals
https://www.readbyqxmd.com/read/28479758/ureteric-injury-during-transvaginal-oocyte-retrieval-tvor-and-review-of-literature
#10
Rana A Choudhary, Neelam M Bhise, Alap V Mehendale, Kedar N Ganla
We report a case of ureteric injury during transvaginal oocyte retrieval (TVOR), which was identified immediately (on the operation table) and managed successfully in the same sitting. A 28-year-old woman with primary infertility underwent in-vitro fertilisation (IVF) in a private centre. Because of the policy of doing an ultrasonography post-procedure, she was diagnosed immediately with vaginal vault haematoma and ureteric injury. A double-J catheter was inserted under cystoscopic guidance. A major complication was averted by the timely diagnosis of ureteric injury and its appropriate management...
January 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28479480/complete-excision-of-sacrocolpopexy-mesh-with-autologous-fascia-sacrocolpopexy
#11
Janine L Oliver, Zaid Q Chaudhry, Andrew R Medendorp, Lauren N Wood, Z Chad Baxter, Ja-Hong Kim, Shlomo Raz
OBJECTIVES: To evaluate the safety and short-term efficacy of complete sacrocolpopexy mesh excision with concomitant autologous fascia sacrocolpopexy. METHODS: A retrospective cohort study of patients undergoing complete sacrocolpopexy mesh excision and concomitant autologous fascia sacrocolpopexy from March 2013 to September 2016 was conducted. The primary objective was assessment of perioperative outcomes including complications within 60 days of surgery. The secondary outcome measure was surgical success defined as no need for retreatment by either surgery for apical prolapse or pessary...
May 4, 2017: Urology
https://www.readbyqxmd.com/read/28466457/comparison-of-99mtc-dmsa-renal-scintigraphy-with-biochemical-and-histopathological-findings-in-animal-models-of-acute-kidney-injury
#12
Hossein Fatemikia, Mohammad Seyedabadi, Zynab Karimi, Kiarash Tanha, Majid Assadi, Kaveh Tanha
Biochemical and histological assays are currently used for the diagnosis and characterization of kidney injury. The purpose of this study was to compare technetium-99m-labeled dimercaptosuccinic acid ((99m)Tc-DMSA) renal scintigraphy, as a non-invasive method, with common biochemical and histopathological methods in two animal models of acute kidney injury. Nephrotoxicity was induced either by gentamicin (100 mg/kg/day for one week) or unilateral ureteral ligation (UUO). Renal scintigraphy was performed 1 h after intravenous injection of 99mTc-DMSA (3 mCi)...
May 2, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28461995/is-a-ureteral-stent-required-after-use-of-ureteral-access-sheath-in-presented-patients-who-undergo-flexible-ureteroscopy
#13
Gastón Astroza, Manuel Catalán, Lucas Consigliere, Tomás Selman, José Salvadó, Francisco Rubilar
INTRODUCTION: Use of a ureteral access sheath (UAS) within flexible ureteroscopy (fURS) for the management of kidney and ureteral stones has shown improvements in its effectiveness, but it is also associated with increased risk of ureteral injury. Use of ureteral stent (US) after fURS is recommended by some authors, because of its role in reducing postoperative pain and preventing complications. Our objective is to determine if postoperative stenting is necessary in pre-stented patients that underwent fURS using UAS...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28458345/hydrogen-rich-water-attenuates-renal-injury-and-fibrosis-by-regulation-transforming-growth-factor-%C3%AE-induced-sirt1
#14
Zhaoyu Xing, Wanma Pan, Jing Zhang, Xianlin Xu, Xuemei Zhang, Xiaozhou He, Min Fan
The current research was designed to study the role of hydrogen in renal fibrosis and the renal epithelial to mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1). Hydrogen rich water (HW) was used to treat animal and cell models. Unilateral ureteral obstruction (UUO) was performed on Balb/c mice to create a model of renal fibrosis. Human kidney proximal tubular epithelial cells (HK-2 cells) were treated with TGF-β1 for 36 h to induce EMT. Serum creatinine (Scr) and blood urea nitrogen (BUN) were measured to test renal function, in addition, kidney histology and immunohistochemical staining of alpha-smooth muscle actin (α-SMA) positive cells was performed to examine the morphological changes...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28451770/multi-modality-imaging-of-the-leaking-ureter-why-does-detection-of-traumatic-and-iatrogenic-ureteral-injuries-remain-a-challenge
#15
Abdullah Alabousi, Michael N Patlas, Christine O Menias, David Dreizin, Sanjeev Bhalla, Man Hon, Andres O'Brien, Douglas S Katz
Ureteral injuries are uncommon in trauma patients, accounting for fewer than 1% of all injuries to the urinary tract. These uncommon, yet problematic, injuries can often be overlooked in the standard search pattern on abdominal and pelvic multi-detector CT (MDCT) images, as radiologists focus on more immediate life-threatening injuries. However, early diagnosis and management are vital to reduce potential morbidity. If there is a high clinical index of suspicion for ureteral injuries with penetrating or blunt trauma, or if there is suspected iatrogenic ureteral injury, delayed-phase/urographic-phase MDCT images are essential for confirming the diagnosis...
April 27, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28413644/reduction-in-mirna-125b-5p-levels-is-associated-with-obstructive-renal-injury
#16
Silu Wang, Lianfeng Wu, Linyong Du, Hong Lu, Bicheng Chen, Yongheng Bai
Obstructive renal injury is a common disease that leads to progressive glomerulosclerosis, tubulointerstitial fibrosis and loss of renal function. MicroRNAs (miRNAs/miRs) are small non-coding molecules that may be involved in the progression of many renal diseases. The aim of the present study was to investigate the roles of miRNAs, including miR-125b, miR-326 and miR-324p, in obstructive renal injury. Blood samples were collected from 91 patients with ureteral obstruction and 76 controls to examine renal function...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28411456/urinary-bladder-injury-during-cesarean-delivery-maternal-outcome-from-a-contemporary-large-case-series
#17
Lina Salman, Shachar Aharony, Anat Shmueli, Arnon Wiznitzer, Rony Chen, Rinat Gabbay-Benziv
BACKGROUND: Urinary bladder injury is a rare complication during cesarean delivery. Little is known on maternal outcome following this injury. OBJECTIVE: To evaluate short and long-term maternal outcome following bladder injury during cesarean delivery. STUDY DESIGN: A retrospective case series of all pregnancies complicated by full-thickness bladder injury during cesarean delivery in a single university affiliated tertiary medical center (August 2007-June 2016)...
April 5, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28404199/bowel-function-after-laparoscopic-posterior-sutured-rectopexy-versus-ventral-mesh-rectopexy-for-rectal-prolapse-a-double-blind-randomised-single-centre-study
#18
Lilli Lundby, Lene H Iversen, Steen Buntzen, Pål Wara, Katrine Høyer, Søren Laurberg
BACKGROUND: Laparoscopic ventral mesh rectopexy for rectal prolapse has been widely used over the past decade to reduce postoperative functional bowel disorders. We aimed to compare changes in functional outcome 12 months after laparoscopic ventral mesh rectopexy versus laparoscopic posterior sutured rectopexy in patients with rectal prolapse. METHODS: In this double-blind, randomised trial, consecutive patients aged 18 years or older at a single centre in Denmark with full-thickness rectal prolapse were randomly assigned (1:1) to either laparoscopic ventral mesh rectopexy or laparoscopic posterior sutured rectopexy by drawing numbers from opaque envelopes, in blocks of four for patients with or without preoperative constipation...
December 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403495/-diagnosis-and-therapeutic-management-in-kidney-ureter-and-bladder-trauma
#19
Karin Hirsch, Marco Heinz, Bernd Wullich
Trauma refers to the destruction of tissues or organs by external forces and it is the most common cause of mortality and morbidity in children (1, 2). Injuries of the genitourinary tract may be the result of blunt (falls, sport injuries, motor vehicle accidents and sexual abuse) or penetrating (stab wounds, gun shots, falling onto sharp objects) injuries. The genitourinary tract is significantly injured in 2.9% of paediatric trauma patients 4.In the paediatric population, the kidney is the most affected organ in the genitourinary tract (>60% of all genitourinary tract injuries) 4...
February 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28402979/the-inhibitory-effect-of-eplerenone-on-cell-proliferation-in-the-contralateral-kidneys-of-rats-with-unilateral-ureteral-obstruction
#20
Cong-Hui Wang, Zheng Wang, Li-Juan Liang, Xiang-Ting Wang, Xue-Lian Ma, Bei-Bei Liu, Jia-Qi He, Tatsuo Shimosawa, Qing-You Xu
BACKGROUND: The unilateral ureteral obstruction (UUO) model not only induces renal interstitial fibrosis in the obstructed kidney but also induces injury in the contralateral kidney. We hypothesized that activation of the mineralocorticoid receptor (MR) may induce fibrosis in the early stage of UUO. METHODS: Thirty male Sprague-Dawley rats weighting 200 ± 10 g were used in this study and randomly divided into 3 groups: a UUO group, a UUO and eplerenone group, and a sham group...
April 13, 2017: Nephron
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